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I started my scientific career deeply engaged with drug discovery and with the development of innovative synthetic strategies and procedures to obtain concise and diverse-orientated chemical libraries based on natural products. The obtained libraries were screened toward several biological targets to develop enzymatic inhibitors and ligands of adenosine receptors aiming the discovery and development of new drug candidates to address multifactorial diseases such as cancer and neurodegenerative diseases. In addition, when required, I have performed the antioxidant evaluation of diverse system. Over the years I have been genuinely engaged in acquiring and developing a vast number of skills in the field of medicinal chemistry, allowing me to be aware of the importance of its transdisciplinary research and of the tools that are involved in the daily routine of the multidisciplinary R&D projects and of the overall process inherent to drug discovery and development. Currently, My research is focused on the design and development of new antimicrobial drugs based on naturally-occurring privileged structures. In this context, I collaborate with LEPABE in the group of Prof. Manuel Simões, to improve my skills in the area, and I establish an international collaboration with CO-ADD (Community for Open Antimicrobial Drug Discovery). At present more than 50 compounds were screened against several antibacterial and antifungal strains.
Identificação

Identificação pessoal

Nome completo
Alexandra Maria Neves Gaspar

Nomes de citação

  • Gaspar, Alexandra

Identificadores de autor

Ciência ID
1A19-6480-E6F1
ORCID iD
0000-0002-3892-4124

Endereços de correio eletrónico

  • alexandra.gaspar@fc.up.pt (Profissional)

Moradas

  • CIQ. Rua Campo Alegre, 4169-007, Porto, Porto, Portugal (Profissional)

Websites

  • https://drugdiscoveryup.pt (Profissional)

Domínios de atuação

  • Ciências Exatas - Química
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2009/03/01 - 2013/12/09
Concluído
Química (Doutoramento)
Especialização em Química Medicinal
Universidade do Porto Faculdade de Ciências, Portugal
"Chromone as a privileged scaffold in medicinal chemistry" (TESE/DISSERTAÇÃO)
Aprovado com distinção
2004 - 2007
Concluído
Controlo de Qualidade e Toxicologia dos Alimentos (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
18
2004 - 2005
Concluído
Controlo da Qualidade e Toxicologia dos Alimentos (Especialização pós-licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
17
1996 - 2002
Concluído
Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
12
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/01/15 - Atual Investigador Contratado (Investigação) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
2014/03/01 - 2019/01/14 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
2018/09/01 - 2018/11/30 Investigador visitante (Investigação) Università degli Studi di Cagliari, Itália

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2010/10/01 - 2011/02/28 Assistente (Docente Universitário) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2007/10/09 - 2007/12/31 Assistente (Docente Ensino Superior Politécnico) ETGI-AESBUC (Associação para a Escola Superior de Biotecnologia da Universidade Católica), Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2019/09/01 - 2025/01/05 Colaboração à Docência Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
2017/04/02 - 2017/07/30 Investigador Visitante Universidade de Santiago de Compostela, Espanha
Projetos

Projeto

Designação Financiadores
2018 - Atual Development of centrally-active and safe catechol O-methyltransferase inhibitors
POCI-01-0145-FEDER-029164
Investigador
Associação para a Inovação e Desenvolvimento da FCT
2018 - Atual Development of new antibiotics for aquaculture
POCI-01-0145-FEDER-028397
Investigador
Universidade do Porto Centro de Investigação em Química, Portugal
Em curso
2016 - Atual Sustainable advanced materials
NORTE-01-0145-FEDER-000028
Investigador
Universidade do Porto Centro de Investigação em Química, Portugal
Concluído
2014 - Atual Development of Functional Materials
NORTE-07-0124-FEDER-000065
Investigador
Universidade do Porto Centro de Investigação em Química, Portugal
Concluído
2022 - 2023/07/01 A estratégia do Cavalo de Troia para o desenvolvimento de antibacterianos contra microrganismos multirresistentes
EXPL/MED-QUI/1156/2021
Investigador responsável
Universidade do Porto Centro de Investigação em Química, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2011 - 2014 BP4Brain - Benzopyrane as a privileged structure for the rational design of multi-target-directed drugs potentially useful in neurodegenerative diseases
Universidade do Porto Centro de Investigação em Química, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2013/07/31 NEW THERAPEUTIC APROACHES IN CANCER:DESIGN AND SYNTHESIS OF NEW A3 RECEPTOR LIGANDS
SFRH/BD/43531/2008
Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2011/03/31 Novas abordagens terapêuticas no cancro: desenho racional e síntese de novos ligandos dos receptores A3 da adenosina
PTDC/QUI/70359/2006
Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal

Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2011 Rational design and synthesis of new adenosine A3 receptor ligands
PTDC/QUI/70359/2006
Bolseiro de Investigação
Universidade do Porto Faculdade de Farmácia, Portugal
Concluído
2005 - 2007/04/15 Desenvolvimento de Novos Agentes Anticancerígenos: Derivados Fenólicos de Origem Natural ou Sintética - Relações Estrutura-Actividade
POCI/QUI/55631/2004
Universidade de Coimbra, Portugal

Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Maruca, Annalisa; Rocca, Roberta; Gil Martins, Eva; Barreiro, Sandra; et al. Autor correspondente: Gaspar, Alexandra. "Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?". Journal of Medicinal Chemistry 64 15 (2021): 11169-11182. http://dx.doi.org/10.1021/acs.jmedchem.1c00510.
    10.1021/acs.jmedchem.1c00510
  2. Francesco Mesiti; Annalisa Maruca; Vera Silva; Roberta Rocca; Carlos Fernandes; Fernando Remião; Eugenio Uriarte; et al. Autor correspondente: Alexandra Gaspar. "4-Oxoquinolines and monoamine oxidase: When tautomerism matters". European Journal of Medicinal Chemistry (2021): 113183-113183. https://doi.org/10.1016/j.ejmech.2021.113183.
    10.1016/j.ejmech.2021.113183
  3. Gomes, Ligia R.; Low, John Nicolson; Borges, Fernanda; Gaspar, Alexandra; Mesiti, Francesco. "The synthesis, crystal structure and Hirshfeld analysis of 4-(3,4-dimethylanilino)-N-(3,4-dimethylphenyl)quinoline-3-carboxamide". Acta Crystallographica Section E Crystallographic Communications 76 2 (2020): 201-207. http://dx.doi.org/10.1107/s2056989020000298.
    10.1107/s2056989020000298
  4. Mesiti, Francesco; Chavarria, Daniel; Gaspar, Alexandra; Alcaro, Stefano; Borges, Fernanda. Autor correspondente: Gaspar, Alexandra. "The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease". European Journal of Medicinal Chemistry 181 (2019): 111572. http://dx.doi.org/10.1016/j.ejmech.2019.111572.
    Publicado • 10.1016/j.ejmech.2019.111572
  5. Gaspar, A.; Mohabbati, M.; Cagide, F.; Razzaghi-Asl, N.; Miri, R.; Firuzi, O.; Borges, F.. "Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds". Research in Pharmaceutical Sciences 14 1 (2019): 74-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061659825&partnerID=MN8TOARS.
    10.4103/1735-5362.251855
  6. Oliveira, C.; Gaspar, A.; Gomes, L.R.; Low, J.N.; Borges, F.; Cagide, F.. "Structural elucidation of a series of benzamide derivatives". Magnetic Resonance in Chemistry 56 3 (2018): 216-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037652503&partnerID=MN8TOARS.
    10.1002/mrc.4682
  7. Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Correction to: Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors (Journal of Medicinal Chemistry (2016) 59 (5879-5893) DOI: 10.1021/acs.jmedchem.6b00527)". Journal of Medicinal Chemistry 61 11 (2018): 5054-5054. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048642711&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.8b00600
  8. Reis, J.; Gaspar, A.; Milhazes, N.; Borges, F.. "Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances". Journal of Medicinal Chemistry 60 19 (2017): 7941-7957. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031293351&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.6b01720
  9. Low, J.N.; Gomes, L.R.; Gaspar, A.; Borges, F.. "Structure of 7-hydroxy-3-(2-methoxyphenyl)-2-trifluoromethyl-4H-chromen-4-one". Acta Crystallographica Section E: Crystallographic Communications 73 (2017): 1130-1134. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029517534&partnerID=MN8TOARS.
    10.1107/S2056989017009896
  10. Borges, A.; Sousa, P.; Gaspar, A.; Vilar, S.; Borges, F.; Simões, M.. "Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes". Biofouling 33 2 (2017): 156-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011301293&partnerID=MN8TOARS.
    10.1080/08927014.2017.1280732
  11. Fonseca, A.; Gaspar, A.; Matos, M.J.; Gomes, L.R.; Low, J.N.; Uriarte, E.; Borges, F.. "Structural elucidation of a series of 6-methyl-3-carboxamidocoumarins". Magnetic Resonance in Chemistry 55 4 (2017): 373-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-85000471196&partnerID=MN8TOARS.
    10.1002/mrc.4541
  12. Cagide, F.; Reis, J.; Gaspar, A.; Chavarria, D.; Kachler, S.; Klotz, K.N.; Gomes, L.R.; et al. "Discovery of the first A1 adenosine receptor ligand based on the chromone scaffold". RSC Advances 6 52 (2016): 46972-46976. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969939884&partnerID=MN8TOARS.
    10.1039/c6ra02347a
  13. Oliveira, J.A.S.A.; Oliveira, T.S.M.; Gaspar, A.; Borges, F.; Ribeiro da Silva, M.D.M.C.; Monte, M.J.S.. "Study on the volatility of halogenated fluorenes". Chemosphere 157 (2016): 25-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968830414&partnerID=MN8TOARS.
    10.1016/j.chemosphere.2016.05.014
  14. Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors". Journal of Medicinal Chemistry 59 12 (2016): 5879-5893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975871993&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.6b00527
  15. Gonçalves, A.L.; Abreu, A.C.; Coqueiro, A.; Gaspar, A.; Borges, F.; Choi, Y.H.; Pires, J.C.M.; Simões, M.. "Co-cultivation of Synechocystis salina and Pseudokirchneriella subcapitata under varying phosphorus concentrations evidences an allelopathic competition scenario". RSC Advances 6 61 (2016): 56091-56100. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975041703&partnerID=MN8TOARS.
    10.1039/c6ra07771d
  16. Fernandes, C.; Soares, P.; Gaspar, A.; Martins, D.; Gomes, L.R.; Low, J.N.; Borges, F.. "Synthesis of 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester derivatives". Tetrahedron Letters 57 27-28 (2016): 3006-3010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973109330&partnerID=MN8TOARS.
    10.1016/j.tetlet.2016.05.096
  17. Gomes, L.R.; Low, J.N.; Fernandes, C.; Gaspar, A.; Borges, F.. "Crystal structures of ethyl 6-(4-methylphenyl)-4-oxo-4H-chromene-2-carboxylate and ethyl 6-(4-fluorophenyl)-4-oxo-4H-chromene-2-carboxylate". Acta Crystallographica Section E: Crystallographic Communications 72 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954144374&partnerID=MN8TOARS.
    10.1107/S2056989015022781
  18. Cagide, F.; Silva, T.; Reis, J.; Gaspar, A.; Borges, F.; Gomes, L.R.; Low, J.N.. "Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry". Chemical Communications 51 14 (2015): 2832-2835. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922432422&partnerID=MN8TOARS.
    10.1039/c4cc08798d
  19. Gaspar, A.; Milhazes, N.; Santana, L.; Uriarte, E.; Borges, F.; Matos, M.J.. "Oxidative stress and neurodegenerative diseases: Looking for a therapeutic solution inspired on benzopyran chemistry". Current Topics in Medicinal Chemistry 15 5 (2015): 432-445. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930908241&partnerID=MN8TOARS.
  20. Cagide, F.; Gaspar, A.; Reis, J.; Chavarria, D.; Vilar, S.; Hripcsak, G.; Uriarte, E.; et al. "Navigating in chromone chemical space: Discovery of novel and distinct A3 adenosine receptor ligands". RSC Advances 5 96 (2015): 78572-78585. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942156288&partnerID=MN8TOARS.
    10.1039/c5ra14988f
  21. Gomes, L.R.; Low, J.N.; Cagide, F.; Gaspar, A.; Borges, F.. "A comparison of the structures of some 2- and 3-substituted chromone derivatives: A structural study on the importance of the secondary carboxamide backbone for the inhibitory activity of MAO-B". Acta Crystallographica Section E: Crystallographic Communications 71 (2015): 1270-1277. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948458262&partnerID=MN8TOARS.
    10.1107/S2056989015017958
  22. Reis, J.; Gaspar, A.; Borges, F.; Rebelo Gomes, L.; Low, J.N.. "Synthesis, spectroscopic characterization and X-ray structure of novel 7-methoxy-4-oxo-N-phenyl-4H-chromene-2-carboxamides". Journal of Molecular Structure 1056-1057 1 (2014): 31-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886478757&partnerID=MN8TOARS.
    10.1016/j.molstruc.2013.09.024
  23. Gaspar, A.; Matos, M.J.; Garrido, J.; Uriarte, E.; Borges, F.. "Chromone: A valid scaffold in medicinal chemistry". Chemical Reviews 114 9 (2014): 4960-4992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900440197&partnerID=MN8TOARS.
    10.1021/cr400265z
  24. Fernandes, C.; Encarnação, I.; Gaspar, A.; Garrido, J.; Borges, F.; Garrido, E.M.. "Influence of hydroxypropyl- ß -cyclodextrin on the photostability of fungicide pyrimethanil". International Journal of Photoenergy 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84897555260&partnerID=MN8TOARS.
    10.1155/2014/489873
  25. Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F.. "Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids". European Journal of Medicinal Chemistry 62 (2013): 289-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030904&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.12.049
  26. Helguera, A.M.; Pérez-Garrido, A.; Gaspar, A.; Reis, J.; Cagide, F.; Vina, D.; Cordeiro, M.N.D.S.; Borges, F.. "Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors". European Journal of Medicinal Chemistry 59 (2013): 75-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870213017&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.10.035
  27. Gomes, L.R.; Low, J.N.; Cagide, F.; Gaspar, A.; Reis, J.; Borges, F.. "Structural characterization of some N-phenyl-4-oxo-4H-2-chromone carboxamides". Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials 69 3 (2013): 294-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881167454&partnerID=MN8TOARS.
    10.1107/S2052519213009676
  28. Teixeira, J.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F.. "Hydroxycinnamic acid antioxidants: An electrochemical overview". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84881540701&partnerID=MN8TOARS.
    10.1155/2013/251754
  29. Gaspar, A.; Cagide, F.; Quezada, E.; Reis, J.; Uriarte, E.; Borges, F.. "Synthesis and NMR studies of novel chromone-2-carboxamide derivatives". Magnetic Resonance in Chemistry 51 4 (2013): 251-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254988&partnerID=MN8TOARS.
    10.1002/mrc.3937
  30. Matos, M.J.; Hogger, V.; Gaspar, A.; Kachler, S.; Borges, F.; Uriarte, E.; Santana, L.; Klotz, K.-N.. "Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins". Journal of Pharmacy and Pharmacology 65 11 (2013): 1590-1597. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886085159&partnerID=MN8TOARS.
    10.1111/jphp.12135
  31. Matos, M.J.; Gaspar, A.; Kachler, S.; Klotz, K.-N.; Borges, F.; Santana, L.; Uriarte, E.. "Targeting adenosine receptors with coumarins: Synthesis and binding activities of amide and carbamate derivatives". Journal of Pharmacy and Pharmacology 65 1 (2013): 30-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870870474&partnerID=MN8TOARS.
    10.1111/j.2042-7158.2012.01571.x
  32. Reis, J.; Gaspar, A.; Borges, F.; Gomes, L.R.; Low, J.N.. "4-Oxo-N-phenyl-4H-chromene-2-carboxamide and of a new polymorph of 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide and its hemihydrate". Acta Crystallographica Section C: Crystal Structure Communications 69 12 (2013): 1527-1533. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890072345&partnerID=MN8TOARS.
    10.1107/S0108270113029727
  33. Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold". Free Radical Research 46 5 (2012): 600-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS.
    10.3109/10715762.2012.662593
  34. Gaspar, A.; Reis, J.; Matos, M.J.; Uriarte, E.; Borges, F.. "In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-¿-pyrone skeleton". European Journal of Medicinal Chemistry 54 (2012): 914-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864409949&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.05.033
  35. Garrido, J.; Gaspar, A.; Garrido, E.M.; Miri, R.; Tavakkoli, M.; Pourali, S.; Saso, L.; Borges, F.; Firuzi, O.. "Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress". Biochimie 94 4 (2012): 961-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857454548&partnerID=MN8TOARS.
    10.1016/j.biochi.2011.12.015
  36. Matos, M.J.; Gaspar, A.; Borges, F.; Uriarte, E.; Santana, L.. "Improved synthesis of 3-(aminoaryl)coumarins". Organic Preparations and Procedures International 44 6 (2012): 522-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870010404&partnerID=MN8TOARS.
    10.1080/00304948.2012.730937
  37. Gaspar, A.; Reis, J.; Kachler, S.; Paoletta, S.; Uriarte, E.; Klotz, K.-N.; Moro, S.; Borges, F.. "Discovery of novel A 3 adenosine receptor ligands based on chromone scaffold". Biochemical Pharmacology 84 1 (2012): 21-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860664996&partnerID=MN8TOARS.
    10.1016/j.bcp.2012.03.007
  38. Borges, F.; Reis, J.; Encarnação, I.; Gaspar, A.; Morales, A.; Milhazes, N.. "Parkinson's disease management. part iidiscovery of mao-b inhibitors based on nitrogen heterocycles and analogues". Current Topics in Medicinal Chemistry 12 20 (2012): 2116-2130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874913282&partnerID=MN8TOARS.
  39. Gaspar, A.; Reis, J.; Fonseca, A.; Milhazes, N.; Viña, D.; Uriarte, E.; Borges, F.. "Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors". Bioorganic and Medicinal Chemistry Letters 21 2 (2011): 707-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651257725&partnerID=MN8TOARS.
    10.1016/j.bmcl.2010.11.128
  40. Cagide, F.; Reis, J.; Gaspar, A.; Borges, F.. "Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis". Tetrahedron Letters 52 48 (2011): 6446-6449. http://www.scopus.com/inward/record.url?eid=2-s2.0-80255127537&partnerID=MN8TOARS.
    10.1016/j.tetlet.2011.09.095
  41. Menezes, J.C.J.M.D.S.; Kamat, S.P.; Cavaleiro, J.A.S.; Gaspar, A.; Garrido, J.; Borges, F.. "Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates". European Journal of Medicinal Chemistry 46 2 (2011): 773-777. http://www.scopus.com/inward/record.url?eid=2-s2.0-79151481300&partnerID=MN8TOARS.
    10.1016/j.ejmech.2010.12.016
  42. Gaspar, A.; Silva, T.; Yáñez, M.; Vina, D.; Orallo, F.; Ortuso, F.; Uriarte, E.; et al. "Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors". Journal of Medicinal Chemistry 54 14 (2011): 5165-5173. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960651250&partnerID=MN8TOARS.
    Publicado • 10.1021/jm2004267
  43. Gaspar, A.; Teixeira, F.; Uriarte, E.; Milhazes, N.; Melo, A.; Cordeiro, M.N.D.S.; Ortuso, F.; Alcaro, S.; Borges, F.. "Towards the Discovery of a Novel Class of Monoamine Oxidase Inhibitors: Structure-Property-Activity and Docking Studies on Chromone Amides". ChemMedChem 6 4 (2011): 628-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066953&partnerID=MN8TOARS.
    10.1002/cmdc.201000452
  44. Gaspar, A.; Silva, T.; Borges, F.. "Adenosine a3 receptors: A new therapeutic approach in cancer,Receptores a3 da adenosina: uma nova abordagem terapêutica no câncer". Quimica Nova 34 8 (2011): 1417-1424. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054893720&partnerID=MN8TOARS.
    10.1590/S0100-40422011000800022
  45. Gaspar, A.; Martins, M.; Silva, P.; Garrido, E.M.; Garrido, J.; Firuzi, O.; Miri, R.; Saso, L.; Borges, F.. "Dietary phenolic acids and derivatives. Evaluation of the antioxidant activity of sinapic acid and its alkyl esters". Journal of Agricultural and Food Chemistry 58 21 (2010): 11273-11280. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149321255&partnerID=MN8TOARS.
    10.1021/jf103075r
  46. Alcaro, S.; Gaspar, A.; Ortuso, F.; Milhazes, N.; Orallo, F.; Uriarte, E.; Yáñez, M.; Borges, F.. "Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B". Bioorganic and Medicinal Chemistry Letters 20 9 (2010): 2709-2712. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950954802&partnerID=MN8TOARS.
    10.1016/j.bmcl.2010.03.081
  47. Gaspar, A.; Garrido, E.M.; Esteves, M.; Quezada, E.; Milhazes, N.; Garrido, J.; Borges, F.. "New insights into the antioxidant activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives". European Journal of Medicinal Chemistry 44 5 (2009): 2092-2099. http://www.scopus.com/inward/record.url?eid=2-s2.0-62749186901&partnerID=MN8TOARS.
    10.1016/j.ejmech.2008.10.027
  48. Machado, N.F.L.; Calheiros, R.; Gaspar, A.; Garrido, J.; Borgesa, F.; Marques, M.P.M.. "Antioxidant phenolic esters with potential anticancer activity: Solution equilibria studied by Raman spectroscopy". Journal of Raman Spectroscopy 40 1 (2009): 80-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962407137&partnerID=MN8TOARS.
    10.1002/jrs.2083
  49. Esteves, M.; Siquet, C.; Gaspar, A.; Rio, V.; Sousa, J.B.; Reis, S.; Marques, M.P.M.; Borges, F.. "Antioxidant versus cytotoxic properties of hydroxycinnamic acid derivatives - A new paradigm in phenolic research". Archiv der Pharmazie 341 3 (2008): 164-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649198620&partnerID=MN8TOARS.
    10.1002/ardp.200700168
  50. Calheiros, R.; Machado, N.F.L.; Fiuza, S.M.; Gaspar, A.; Garrido, J.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "Antioxidant phenolic esters with potential anticancer activity: A Raman spectroscopy study". Journal of Raman Spectroscopy 39 1 (2008): 95-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549148538&partnerID=MN8TOARS.
    10.1002/jrs.1822
  51. Marques, M.P.M.; Borges, F.; Sousa, J.; Calheiros, R.; Garrido, J.; Gaspar, A.; Antunes, F.; Diniz, C.; Fresco, P.. "Cytotoxic and COX-2 inhibition properties of hydroxycinnamic derivatives". Letters in Drug Design and Discovery 3 5 (2006): 316-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745603707&partnerID=MN8TOARS.
    10.2174/157018006777574212
Capítulo de livro
  1. Gaspar, Alexandra. "Synthesis of p-conjugated systems using formylchromone as building block". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. 2016.
    Publicado
  2. Gaspar, Alexandra. "Synthesis of 7-methoxy-4-oxo- N-phenyl- 4H-chromene-2-carboxamide". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. Royal Chemical Society, 2016.
    Publicado
  3. Gaspar, Alexandra. "Molecular Physicochemistry- a Tool for the Rational Development of New Antioxidants". In New Strides in Biotechnology. 2008.
Poster em conferência
  1. Gaspar, Alexandra. "A rational drug discovery approach for the design and development of new antimicrobial agents.". Trabalho apresentado em MuTaLig COST ACTION CA15135, 2020.
  2. Gaspar, Alexandra. "Evaluation of benzopyrone pharmacophore features on MAO-B inhibition". Trabalho apresentado em 26th Young Research Fellows meeting, 2019.
  3. Gaspar, Alexandra. "Design and Development of Dual -Target Ligands Based on Benzopyran for the Treatment of Parkinson’s Disease". Trabalho apresentado em 3rd Annual meeting - MuTaLig COST Action, 2018.
  4. Gaspar, Alexandra. "Mapping the Pharmacophore of Benzopyrone MAO-B Inhibitors". Trabalho apresentado em VIII Meeting of the Paul Ehrlich EuroPhD Network, 2018.
  5. Gaspar, Alexandra. "Development of new antimicrobial agents based on the chromone scaffold". Trabalho apresentado em VIII Meeting of the Paul Ehrlich EuroPhD Network, 2018.
  6. Gaspar, Alexandra. "Benzopyrane as a valid scaffold for the development of multitarget ligands for neurodegenerative diseases". Trabalho apresentado em 1st annual meeting – MuTaLig COST Action, 2016.
  7. Gaspar, Alexandra. "Search of new antibacterial compounds inspired on benzopyran scaffold". Trabalho apresentado em Meeting of the Paul Ehrlich Euro-PhD Network, 2015.
  8. Hugues, Edgar. "Development of new adenosine receptors ligands based on chromone scaffold: adventures in the design and optimization process". Trabalho apresentado em Meeting of the Paul Ehrlich Euro-PhD Network, 2015.
  9. Gaspar, Alexandra. "Development of A3 adenosine receptor ligands by an analogue-based approach". Trabalho apresentado em XXII Young Research Fellow Meeting, 2015.
  10. Gaspar, Alexandra. "Discovery of new leads for old targets: insights on the lead optimization process of a new MAO-B inhibitor based on chromone scaffold". Trabalho apresentado em 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network–Hradec Králové, República Checa, 2014.
  11. Gaspar, Alexandra. "“Chromone: a valid scaffold in medicinal chemistry". Trabalho apresentado em 4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network - Hradec Králové, Praga, República Checa, 2014.
  12. Gaspar, Alexandra. "MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria". Trabalho apresentado em 8th World Congress on Polyphenols Applications: ISANH Polyphenols - Lisboa, Portugal, 2014.
  13. Gaspar, Alexandra. "Remaking of Dietary Antioxidants: Targeting MitoBEN’s to Mitochondria as a New Therapeutic Strategy". Trabalho apresentado em 10º Portuguese National Meeting of Organic Chemistry – 1st Portuguese– Brazilian Organic Chemistry Symposium–, 2013.
  14. Gaspar, Alexandra. "Targeted Delivery of MitoCIN’S: a New Therapeutic Approach for Oxidative Stress Related Diseases". Trabalho apresentado em 10º Portuguese National Meeting of Organic Chemistry – 1st Portuguese– Brazilian Organic Chemistry Symposium–, 2013.
  15. Gaspar, Alexandra. "Nature-Inspired Artwoark: Development of 6-(Heteroaryl/Aryl) Chromones as Novel Adenosine Receptor Ligands". Trabalho apresentado em III SEQT Summer School – Medicinal Chemistry in Drug Discovery: The Pharma Perspective–Madrid, Espanha,, 2013.
  16. Gaspar, Alexandra. "Development of new dual-target strategy for the discovery of new anti-Parkinson drugs". Trabalho apresentado em III SEQT Summer School – Medicinal Chemistry in Drug Discovery: The Pharma Perspective–Madrid, Espanha,, 2013.
  17. Gaspar, Alexandra. "Development of new dual-target MAO-B/AChE inhibitors based on chromone derivatives". Trabalho apresentado em Frontiers in Medicinal Chemistry–São Francisco, Califórnia, EUA,, 2013.
  18. Gaspar, Alexandra. "Parkinson disease and non-dopaminergic therapy: synthesis and evaluation of new adenosine receptors antagonists based on benzo-¿-pyrone scaffold". Trabalho apresentado em 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs–Nova Iorque, EUA, 2012.
  19. Gaspar, Alexandra. "Modulating the pharmacokinetic profile of natural phenolic antioxidants with potential neuroprotective activity". Trabalho apresentado em 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs–Nova Iorque, EUA, 2012.
  20. Gaspar, Alexandra. "Mitochondria-Targeted Cinnamic Antioxidants: Novel Promising Drugs for Treatment of Alzheimer Disease". Trabalho apresentado em 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs–Nova Iorque, EUA, 2012.
  21. Gaspar, Alexandra. "New therapeutic approaches towards neurodegenerative diseases: targeting oxidative damage with innovative lipophilic antioxidants". Trabalho apresentado em 16th RSC_SCI Cambridge Medicinal Chemistry Symposium–Cambridge, Reino Unido, 2011.
  22. Gaspar, Alexandra. "Drug discovery for neurodegenerative diseases: development of novel potent and selective chromone based MAO-B inhibitors". Trabalho apresentado em 16th RSC_SCI Cambridge Medicinal Chemistry Symposium–Cambridge, Reino Unido, 2011.
  23. Gaspar, Alexandra. "Benzo-¿-pyrone based ligands as a privileged scaffold for drug discovery: synthesis and structure-affinity relationships for adenosines rece". Trabalho apresentado em 16th RSC_SCI Cambridge Medicinal Chemistry Symposium–Cambridge, Reino Unido, 2011.
  24. Gaspar, Alexandra. "New mitochondria-targeted antioxidants based on cinnamic scaffold for neurodegenerative disease therapy". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal,, 2011.
  25. Gaspar, Alexandra. "Chromone-based adenosine receptor ligands: a new challenge in the anticancer drug discovery scenario". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011.
  26. Gaspar, Alexandra. "Targeting phenolic antioxidants to mitochondria: synthesis and characterization of novel triphenylphosphonium-conjugated lipophilic cinnamic derivatives". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, 2011.
  27. Gaspar, Alexandra. "Design and development of a novel chemical library, based on a privileged scaffold, suitable to speed up the drug discovery process of IMAO-B”". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, 2011.
  28. Gaspar, Alexandra. "Accelerating lead optimization of MAO inhibitors throughout microwaveassisted organic synthesis". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011.
  29. Leferink, Frank; Blaj, Alex; Hogeman, Edwin; Storck, Rob. "Using preloading to protect bearings against lightning damage". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011.
    10.1109/sipda.2015.7339301
  30. Gaspar, Alexandra. "Development of novel lipophilic antioxidants based on ferulic acid". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011.
  31. Rivero, Ralph A.; Hardwicke, Mary Ann. "Abstract 2913: Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Ka) for the treatment of PTEN deficient tumors". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011.
    10.1158/1538-7445.am2012-2913
  32. Sonoda, Kenzo. "Abstract C256: New therapeutic modalities by targeting RCAS1 which induces apoptosisviaectodomain shedding mediated by ADAM9". Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies–Barcelona, Espanha, 2009.
    10.1158/1535-7163.targ-09-c256
  33. Gaspar, Alexandra. "QSAR model for predicting binding affinity to adenosine A2b receptors of antagonists based on chromone scaffold". Trabalho apresentado em Third Joint Italian–German Purine Club Meeting Purinergic Receptors: New Frontiers for Novel Therapies–Camerino, Itália, 2009.
  34. Gaspar, Alexandra. "From nature to drug discovery: the chromone scaffold as a privileged structure¿ for the development of novel A3 receptor ligands". Trabalho apresentado em III EWDSy–Third European Workshop in Drug Synthesis, University of Siena– Siena, Itália,, 2009.
  35. Gaspar, Alexandra. "Biological activity of novel esters structurally based on a natural phenolic acid model". Trabalho apresentado em Metabolic Toxicology: from Pathway to Organism – International Courses on Toxicology, Cell and Molecular Toxicology Research Area, Centre for Neurosciences and Cell Biology of the University of Coimbra–Coimbra, Portugal, 2008.
  36. Gaspar, Alexandra. "Phenolic Alkyl Esters with Potential Anticancer Activity: A Raman Spectroscopy Study in the Solid State". Trabalho apresentado em 12th European Conference on the Spectroscopy of Biological Molecules (ECSBM–12)–Bobigny, Paris, França, 2007.
  37. Gaspar, Alexandra. "Phenolic Esters with Potential Anticancer Activity: Solution Equilibria Studied by Raman Spectroscopy". Trabalho apresentado em 12th European Conference on the Spectroscopy of Biological Molecules (ECSBM–12)–Bobigny, Paris, Franç, 2007.
  38. Gaspar, Alexandra. "Therapeutic anti-inflammatory strategies based on targeting adenosine receptors". Trabalho apresentado em International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC07)–St. Petersburgo, Rússia, 2007.
  39. Gaspar, Alexandra. "Novel Therapeutic approaches in cancer: design and synthesis of new adenosine A3 Receptor ligands". Trabalho apresentado em First Iberic Meeting on Medicinal Chemistry–anticancer agents–Régua, Portugal, 2007.
  40. Gaspar, Alexandra. "New insights in the therapeutic value of hydroxyl cinnamic derivatives: cytotoxic and COX-2 inhibition properties". Trabalho apresentado em First Iberic Meeting on Medicinal Chemistry–anticancer agents–Régua, Portugal, 2007.
  41. Gaspar, Alexandra; Machado, N.F.L.; Calheiros, R.; Fiuza, S.M.; Borges, F.; Gaspar, A.; Garrido, J.; Marques, M.P.. "Phenolic esters with potential anticancer activity the structural Variable". Trabalho apresentado em First Iberic Meeting on Medicinal Chemistry–anticancer agents–Régua, Portugal, 2007.
    10.1007/s00894-007-0174-y
  42. Gaspar, Alexandra. "Alkyl Phenolic Esters – A Raman Spectroscopy Study". Trabalho apresentado em IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha,, 2006.
  43. Gaspar, Alexandra. "New Potential Nonsteroidal Aromatase Inhibitors: A Raman Spectroscopy Study". Trabalho apresentado em IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha, 2006.
  44. Gaspar, Alexandra. "Structural Elucidation of New Potential Selective A2A Adenosine Receptor Agonists by Raman Spectroscopy". Trabalho apresentado em IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha, 2006.
  45. Gaspar, Alexandra. "Spectroscopic Studies on Hydroxycinnamic Acid Derivatives as Potential Antiinflammatory Agents". Trabalho apresentado em IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha, 2006.
  46. Gaspar, Alexandra. "Design and Synthesis of Novel Hydroxycinnamic Derivatives with Cytotoxic, Antioxidant and Anti-inflammatory Activities". Trabalho apresentado em 3rd International Conference on Oxidative Stress in Skin Medicine and Biology– Andros, Grécia,, 2006.
  47. Gaspar, Alexandra. "Phenolic Derivatives as Potential Anticancer Agents". Trabalho apresentado em 3rd International Conference on Oxidative Stress in Skin Medicine and Biology– Andros, Grécia, 2006.
  48. Gaspar, Alexandra. "Anticancer and Anti-inflammatory Properties of Hydroxycinnamic Derivatives". Trabalho apresentado em XXIII International Conference on Polyphenols, 2006.
  49. Gaspar, Alexandra. "Evaluation of anti-inflammatory and anti-cancer properties of synthetic hydroxycinnamic derivatives". Trabalho apresentado em 66th Intern. Pharm. Fed. Congress–Salvador Bahia, Brasil, 2006.
  50. Gaspar, Alexandra. "Synthesis of Novel Chromone Derivatives as Potential Lypophilic Antioxidants". Trabalho apresentado em International Symposium on Chemistry, Biology and Medicine–, 2006.
  51. Gaspar, Alexandra. "Enzymatic and non-enzymatic synthesis of glutathionil conjugates of cinnamic acids: an experimental and theorical study". Trabalho apresentado em International Symposium on Chemistry, Biology and Medicine, 2006.
  52. Gaspar, Alexandra. "Synthesis of promising antioxidant agents structurally based on cinnamic acid". Trabalho apresentado em International Symposium on Chemistry, Biology and Medicine, 2006.
  53. Gaspar, Alexandra. "Antioxidant versus Anticancer/Anti-inflammatory Properties of Phenolic Derivatives: A New Challenge on Structure-Activity Studies". Trabalho apresentado em Paris Anti–Inflammatory Drugs, 2005.
Recurso online
  1. Gaspar, Alexandra. Multi-target Design, Synthesis and Study of a Selected Series of Carbamates and Esters with Coumarin Scaffold. 2016. http://www.sciforum.net/conf/ecsoc-16/.
  2. Gaspar, Alexandra; Matos, Maria; Olea-azar, Claudio; Perez-Cruz, Fernanda; Borges, Fernanda; Gaspar, Alexandra; Santana, Lourdes; Janeiro, Patricia. Insights into the antioxidant activity of phenolic compounds: Synthesis and electrochemical study of new series of hydroxycoumarins. 2015. http://www.sciforum.net/presentation/617.
    10.3390/ecsoc-15-00617
Resumo em conferência
  1. Gaspar, Alexandra. "Chromone as a privileged structure for lead optimization of new adenosine receptors ligands". Trabalho apresentado em Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, 2014.
    10.1007/s11302-014-9430-7
  2. Volpini, Rosaria; Lambertucci, Catia; Taffi, Sara; Vittori, Sauro; Klotz, Karl-Norbert; Cristalli, Gloria. "A3 adenosine receptors: Synthesis and biological evaluation of new potent and selective ligands". Trabalho apresentado em Purinergic Signalling (2014) 10:657–854- International Conference on Nucleotides, Nucleosides and Nucleobases, Bonn, 2014.
    10.1135/css200507297
  3. Gaspar, Alexandra. "Surpassing the Pharmacokinetic Drawbacks of Natural Phenolic Antioxidants". Trabalho apresentado em XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012.
    Publicado
  4. Gaspar, Alexandra. "Benzopyrone as a privileged scaffold for drug discovery: synthesis and structure–affinity relationships for adenosine receptors". Trabalho apresentado em ChemMedChem ISMC 2012 -XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012.
    Publicado
  5. Gaspar, Alexandra. "Discovery of a novel class of reversible monoamine oxidase B inhibitors based on chromone scaffold". Trabalho apresentado em ChemMedChem ISMC 2012-XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012.
    Publicado
  6. Borghesi, Marco. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Trabalho apresentado em ChemMedChem ISMC 2012-XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012.
    Publicado
  7. Gaspar, Alexandra. "Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Trabalho apresentado em Free Radical Biology and Medicine-Society for Free Radical Research International 16th Biennial Meeting, Londres, 2012.
    Publicado • 10.1016/j.freeradbiomed.2012.08.213
  8. Gaspar, Alexandra. "Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif". Trabalho apresentado em Purinergic Signalling volume 6, pages49–115(2010)-Third joint Italian-German Purine Club meeting: “Purinergic receptors: new frontiers for novel therapies”, Camerino, 2010.
    Publicado • https://doi.org/10.1007/s11302-009-9171-1
  9. Cong, Chunyu; Sun, Pingping; Ma, Zhiqiang. "Predicting binding affinity using differential evolution". Trabalho apresentado em Purinergic Signalling (2010) -Third joint Italian-German Purine Club meeting: “Purinergic receptors: new frontiers for novel therapies”, Camerino, 2010.
    Publicado • 10.1007/s11302-009-9171-1
  10. Boudreau, Michael. "Development of novel systems to deliver natural antioxidants to mitochondria: MitoCIN'S as a case study". Trabalho apresentado em 47th Annual Scientific Meeting of the European Society for Clinical Investigation,, Albufeira, 2007.
    10.1109/sysose.2007.4304229

Propriedade Intelectual

Patente
  1. Gaspar, Alexandra. 2009. "Cromonas e derivados de cromonas com actividade inibidora da monoamina oxidase e aplicações terapêuticas relacionadas". Portugal.
    Concedida/Emitida
  2. Gaspar, Alexandra. 2008. "Novel chromone derivatives, methods of synthesis therefor and use as antioxidants/preservatives". Portugal.
    Concedida/Emitida
  3. Gaspar, Alexandra. 2007. "Novos derivados de cromonas, respectivo processo de síntese e sua utilização como antioxidantes/conservantes".
    Concedida/Emitida

Outros

Conjunto de dados
  1. Gaspar, Alexandra. CCDC 939914: Experimental Crystal Structure Determination.
    10.5517/cc10k1tf
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/02/12 The influence of 4-oxoquinoline tautomerism in the MAOs inhibition 28th Young Research Fellows Meeting
Faculty of Pharmacy, University of Paris (Paris, França)
2020/03/05 Mapping the chromone-3-carboxamide pharmacophore: structure-activity-toxicity and efflux transport studies 4th WG meeting – MuTaLig COST Action – Final stutus of WG meeting Oral
Faculty of Pharmacy - Ege University - Izmir - Turkey (Izmir, Turquia)
2019/06 Looking for the Pharmacophore of Benzopyran MAO-B Inhibitors MedChem19 Catanzaro- IV annual COST ACTION CA15135 meeting/Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting,
(Catanzaro, Itália)
2019/02 Design and development of new chemical entities for the treatment of Parkinson disease MuTaLig COST ACTION CA15135 3rd WG meeting
(Paris, França)
2018/05 Descoberta e desenvolvimento de novos antibacterianos contra bactérias multirresistentes 2ºEncontro Investigadores DQB-FCUP
(Porto, Portugal)
2014/06 Chromone: a valid scaffold in medicinal chemistry 4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cracóvia, República Checa)
2014/06 “MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria” World Congress on Polyphenols Applications: ISANH Polyphenols 2014
(Lisboa, Portugal)
2013/09 Discovery of dual-target agents based on chromone scaffold for Parkinson´s disease 3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Calhari, Itália)
2013/04 Development of novel systems to delivery natural antioxidants to mitochondria: MitoCIN’s as a case study 47th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Albufeira, Portugal)
2013/02 Mitocondriotropic derivatives based on the natural polyphenol caffeic acid as an way out for oxidative stress related diseases IJUP13–6º Encontro de Jovens Investigadores da U. Porto–Porto
(Porto, Portugal)
2013/01 Chromone: a valid scaffold in Medicinal Chemistry 2nd Workshop on Medicinal Chemistry
(Porto)
2013/01 Bridging the gap between nature and phenolic antioxidants 2nd Workshop on Medicinal Chemistry
(Porto, Portugal)
2013/01 Development of Smart Carriers for delivering natural antioxidants to Mitochondria 2nd Workshop on Medicinal Chemistry Drug Discovery and Development: Understanding the R&D process
(Porto, Portugal)
2013 Caracterização do complexo de inclusão do fungicida pirimetanil com a 2-hidroxipropil-ß-ciclodextrina XIX Encontro Galego-Português de Química
(Vigo, Espanha)
2013 Bridging the gap between nature and antioxidant therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold IJUP13–6º Encontro de Jovens Investigadores da U. Porto
(Porto, Portugal)
2012 Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage V Encontro de Jovens Investigadores da UP (IJUP)–Porto
(Porto, Portugal)
2011/11 Striving for success in antioxidant therapy 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Roma, Itália)
2011/11 New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Roma, Itália)
2011/10 Toward the discovery of new lipophilic antioxidants based on cinnamic acid scaffold as mitochondria-directed neuroprotective agents 2nd World Congress on Targeting Mitochondria
(Berlim, Alemanha)
2011 Antioxidant therapy: in search of the magic bullet 2nd World Congress on Targeting Mitochondria
(Berlim, Alemanha)
2010/05 Chromones: a valid scaffold for the development of potent and selective MAO-B inhibitors III European Workshop in Drug Synthesis
(Siena, Itália)
2010 From nature to drug discovery: the chromone scaffold as a ‘privileged structure’ for the development of novel A3 receptor ligands III EWDSy- Third European Workshop in Drug Synthesis
(Siena, Itália)
2009 Searching for novel monoamine oxidase inhibitors based on chromone scaffold XXVIII Meeting of Clinical Pharmacology and IX Meeting of Toxicology
(Porto, Portugal)
2009 Adenosine receptor binding and neurotoxicity of novel chromone based ligands XL Meeting of Portuguese Society of Pharmacology, XXVIII Meeting of Clinical Pharmacology and IX Meeting of Toxicology
(Porto, Portugal)
2008/04 Metabolic Toxicology: from Synthesis to (Bio)analysis International Courses on Toxicology, Cell and Molecular Toxicology Research Area, Centre for Neurosciences and Cell Biology
(Coimbra, Portugal)
2007/12 Opening the Pandora box: The Syntab Contribution to the knowledge on the Toxic Effects of Drugs of Abuse and Their Metabolites XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de Toxicologia
(Coimbra, Portugal)
2006/10 Finding the Toxicophore: a Challenging Target in Medicinal Chemistry Medicinal Chemistry in the 21st Century
(Lisboa, Portugal)
2005/10 Phenolic Derivatives: A Study on the Relationship between Structure, Activity and Physicochemical Parameters Anti-Inflammatory Drugs
(Paris, França)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2022/02 - 2022/07 Descoberta e desenvolvimento de novos antibacterianos contra microrganismos multirresistentes
Coorientador
Química
Universidade do Porto Faculdade de Ciências, Portugal
2021/02 - 2021/07 síntese de novos antimicrobianos baseados em produtos naturais
Coorientador
Química (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2020/01/03 - 2020/07 Síntese de novos antimicrobianos baseados em produtos naturais
Coorientador
Quimica (Licenciatura/Bacharelato)
2020/01 - 2020/06 Desenvolvimento de novos antibióticos baseados em modelos naturais
Orientador
Projecto extracurricular (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2020/01 - 2020/06 Desenvolvimento de novos antibióticos baseados em modelos naturais
Orientador
Projecto extracurricular (Licenciatura/Bacharelato)
2019/01 - 2019/09 Desenvolvimento de novos agentes antimicrobianos baseados em modelos naturais
Coorientador
Quimica (Licenciatura/Bacharelato)
2017 - 2019 Design and synthesis of chromone like derivatives as multitarget ligands: for neurodegeneratives diseases
Coorientador
Doutoramento (Doutoramento)
University “Magna Græcia, Itália
2016 - 2016 Evaluation of antioxidant activity of natural extracts
Coorientador
Doutoramento (Doutoramento)
Università degli Studi di Cagliari, Itália
2014 - 2014 Synthesis, Purification, characterization of Hydroxytirosol, Adenosine and lipoic acid derivatives and evaluation of their antioxidant profile
Coorientador
Doutoramento (Doutoramento)
Università degli Studi di Milano, Itália

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2017/10/14 - Atual Member of the organizing committee of the CIQUP’s workshop meeting (2017/10/17)
Encontro (Membro da Comissão Organizadora)
Universidade do Porto Centro de Investigação em Química, Portugal
2018/07/12 - 2018/07/14 Member of the organizing committee VIII Meeting of the Paul Ehrlich EuroPhD Network (2018/07/12 - 2018/07/14)
Congresso (Membro da Comissão Organizadora)
Universidade do Porto Faculdade de Ciências, Portugal
2017/09/22 - 2017/09/24 Member of the organizing committee of the EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint annual meeting :A bridge between EpiChemBio and MuTaLig COST Actions (2017/09/22)
Congresso (Membro da Comissão Organizadora)
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2016/06/29 - 2016/07/01 Member of the Local Organizing Committee of the 10th World Congress on Polyphenols Applications (2016/06/29)
Congresso (Membro da Comissão Organizadora)
Instituto Politécnico do Porto, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2022/02/11 Efeito de Chalconas em Células da Granulosa
Arguente
Ruben Lourenço Seixas (Outro)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/07/18 Repurposing non-antibiotic drugs for antimicrobial purposes
Arguente principal
Cláudia Cristina Moreira Leão (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/07/10 Desenvolvimento de novos antioxidantes para o tratamento da doença de Alzheimer
Arguente principal
Cláudia Sofia Ferreira Pinto (Outro)
Universidade do Porto Faculdade de Ciências, Portugal
2018/07/07 The use of phytochemicals with EDTA as catheter lock solutions
Arguente principal
João Pedro Rocha Vale (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2018/04/26 Single and multi-target agents for neurodegenerative diseases based on the chromone scaffold”
Arguente
Joana Alexandra Costa Reis (Doutoramento)
Faculdade de Ciencias Universidade do Porto, Portugal
2017/07/13 Síntese de derivados de piperazine com atividade inibitória da acetilcolinesterase como possível tratamento da Doenças de Alzheimer
Arguente principal
Tânia Catarina Pinto Moura (Outro)
Universidade do Porto Faculdade de Ciências, Portugal
2017/07/07 Análisis y predicciones teóricas en medicamentos y alimentos
Arguente principal
Estela Guardado Yordi (Doutoramento)
Universidade de Santiago de Compostela Departamento de Farmacoloxía Farmacia e Tecnoloxía Farmacéutica, Espanha
2016/07/26 Desenvolvimento de novos antioxidantes tendo como base modelos naturais
Arguente principal
Mariana Fontoura da Fonseca Tavares Nogueira (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - Atual Current Medicinal Chemistry Bentham Science
2017 - Atual MedChemComm RSC Publishing
2016 - Atual Biofouling Taylor & Francis Online
2015 - Atual European Journal of Medicinal Chemistry Elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2014 - Atual Advances Methods in Structural Analysis Quimica e bioquimica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2014 - Atual Métodos Avançados de análise estrutural (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal

Membro de associação

Nome da associação Tipo de participação
2016/04/18 - 2020/04/17 COST Action AGA-CA15135-1(MuTaLig) MC substitute member

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2022 - 2022/09 Guest editor Special Issue "In Honor of Prof. Dr. Fernanda Borges’s Contribution"
Membro
2020 - 2021/01/31 Guest Editor of Special Issue "New Insights into Antimicrobial Drug Discovery"
Membro
Distinções

Prémio

2020 best oral communication" Mapping the chromone-3-phenylcarboxamide pharmacophore: structure-activity-cytotoxicity and efflux transport studies"
4th WG meeting – MuTaLig COST Action – Final stutus of WG meeting, Turquia

Outra distinção

2014 Paul Ehrlich MedChem Euro-PhD award
2013 III Escuela de Verano de la SEQT “Medicinal Chemistry in Drug Discovery: The Pharma Perspective
2013 Top-10 most cited articles for the article “Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors” J. Med. Chem., 54 (14), 5165-5173.
2012 ADDF Young Investigator Scholarship
2011 Prémio Provincial al trabajo
2006 Prémio da Spectro para melhor comunicação científica