Identification
Personal identification
- Full name
- Alexandra Maria Neves Gaspar
Citation names
- Gaspar, Alexandra
Author identifiers
- Ciência ID
- 1A19-6480-E6F1
- ORCID iD
- 0000-0002-3892-4124
Email addresses
- alexandra.gaspar@fc.up.pt (Professional)
Addresses
- CIQ. Rua Campo Alegre, 4169-007, Porto, Porto, Portugal (Professional)
Websites
- https://drugdiscoveryup.pt (Professional)
Knowledge fields
- Exact Sciences - Chemical Sciences
- Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
Portuguese (Mother tongue) | |||||
English | Upper intermediate (B2) | Upper intermediate (B2) | Upper intermediate (B2) | Upper intermediate (B2) | Upper intermediate (B2) |
Education
Degree | Classification | |
---|---|---|
2009/03/01 - 2013/12/09
Concluded
|
Química (Doutoramento)
Major in Química Medicinal
Universidade do Porto Faculdade de Ciências, Portugal
"Chromone as a privileged scaffold in medicinal chemistry" (THESIS/DISSERTATION)
|
Aprovado com distinção |
2004 - 2007
Concluded
|
Controlo de Qualidade e Toxicologia dos Alimentos (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
18 |
2004 - 2005
Concluded
|
Controlo da Qualidade e Toxicologia dos Alimentos (Especialização pós-licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
17 |
1996 - 2002
Concluded
|
Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
|
12 |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2019/01/15 - Current | Contracted Researcher (Research) | Universidade do Porto Faculdade de Ciências, Portugal |
Universidade do Porto Centro de Investigação em Química, Portugal | ||
2014/03/01 - 2019/01/14 | Postdoc (Research) | Fundação para a Ciência e a Tecnologia, Portugal |
Universidade do Porto Centro de Investigação em Química, Portugal | ||
2018/09/01 - 2018/11/30 | Visiting Researcher (Research) | Università degli Studi di Cagliari, Italy |
Teaching in Higher Education
Category Host institution |
Employer | |
---|---|---|
2010/10/01 - 2011/02/28 | Assistant (University Teacher) | Cooperativa de Ensino Superior Politécnico e Universitário, Portugal |
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal | ||
2007/10/09 - 2007/12/31 | Assistant (Polytechnic Teacher) | ETGI-AESBUC (Associação para a Escola Superior de Biotecnologia da Universidade Católica), Portugal |
Others
Category Host institution |
Employer | |
---|---|---|
2019/09/01 - 2025/01/05 | Colaboração à Docência | Universidade do Porto Faculdade de Ciências, Portugal |
Universidade do Porto Centro de Investigação em Química, Portugal | ||
2017/04/02 - 2017/07/30 | Investigador Visitante | Universidade de Santiago de Compostela, Spain |
Projects
Contract
Designation | Funders | |
---|---|---|
2018 - Current | Development of centrally-active and safe catechol O-methyltransferase inhibitors
POCI-01-0145-FEDER-029164
Researcher
|
Associação para a Inovação e Desenvolvimento da FCT |
2018 - Current | Development of new antibiotics for aquaculture
POCI-01-0145-FEDER-028397
Researcher
Universidade do Porto Centro de Investigação em Química, Portugal
|
Ongoing
|
2016 - Current | Sustainable advanced materials
NORTE-01-0145-FEDER-000028
Researcher
Universidade do Porto Centro de Investigação em Química, Portugal
|
Concluded
|
2014 - Current | Development of Functional Materials
NORTE-07-0124-FEDER-000065
Researcher
Universidade do Porto Centro de Investigação em Química, Portugal
|
Concluded
|
2022/01/02 - 2023/07/01 | A estratégia do Cavalo de Troia para o desenvolvimento de antibacterianos contra microrganismos multirresistentes
EXPL/MED-QUI/1156/2021
Principal investigator
Universidade do Porto Centro de Investigação em Química, Portugal
Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal |
Fundação para a Ciência e a Tecnologia
Ongoing
|
2011/01/20 - 2014 | BP4Brain - Benzopyrane as a privileged structure for the rational design of multi-target-directed drugs potentially useful
in neurodegenerative diseases
Universidade do Porto Centro de Investigação em Química, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2009/08/01 - 2013/07/31 | NEW THERAPEUTIC APROACHES IN CANCER:DESIGN AND SYNTHESIS OF NEW A3 RECEPTOR LIGANDS
SFRH/BD/43531/2008
Universidade do Porto Faculdade de Ciências, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2008/01/01 - 2011/03/31 | Novas abordagens terapêuticas no cancro: desenho racional e síntese de novos ligandos dos receptores A3 da adenosina
PTDC/QUI/70359/2006
Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade de Coimbra, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
2008 - 2011 | Rational design and synthesis of new adenosine A3 receptor ligands
PTDC/QUI/70359/2006
Research Fellow
Universidade do Porto Faculdade de Farmácia, Portugal
|
Concluded
|
2005/10/15 - 2007/04/15 | Desenvolvimento de Novos Agentes Anticancerígenos: Derivados Fenólicos de Origem Natural ou Sintética - Relações Estrutura-Actividade
POCI/QUI/55631/2004
Universidade de Coimbra, Portugal
Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal Universidade do Porto Faculdade de Farmácia, Portugal Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade do Porto Faculdade de Ciências, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
Book chapter |
|
Conference abstract |
|
Conference poster |
|
Journal article |
|
Online resource |
|
Intellectual property
Patent |
|
Other
Dataset |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2021/02/12 | The influence of 4-oxoquinoline tautomerism in the MAOs inhibition | 28th Young Research Fellows Meeting
Faculty of Pharmacy, University of Paris (Paris, France)
|
2020/03/05 | Mapping the chromone-3-carboxamide pharmacophore: structure-activity-toxicity and efflux transport studies | 4th WG meeting – MuTaLig COST Action – Final stutus of WG meeting Oral
Faculty of Pharmacy - Ege University - Izmir - Turkey (Izmir, Turkey)
|
2019/06 | Looking for the Pharmacophore of Benzopyran MAO-B Inhibitors | MedChem19 Catanzaro- IV annual COST ACTION CA15135 meeting/Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting,
(Catanzaro, Italy)
|
2019/02 | Design and development of new chemical entities for the treatment of Parkinson disease | MuTaLig COST ACTION CA15135 3rd WG meeting
(Paris, France)
|
2018/05 | Descoberta e desenvolvimento de novos antibacterianos contra bactérias multirresistentes | 2ºEncontro Investigadores DQB-FCUP
(Porto, Portugal)
|
2014/06 | Chromone: a valid scaffold in medicinal chemistry | 4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cracóvia, Czech Republic)
|
2014/06 | “MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria” | World Congress on Polyphenols Applications: ISANH Polyphenols 2014
(Lisboa, Portugal)
|
2013/09 | Discovery of dual-target agents based on chromone scaffold for Parkinson´s disease | 3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Calhari, Italy)
|
2013/04 | Development of novel systems to delivery natural antioxidants to mitochondria: MitoCIN’s as a case study | 47th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Albufeira, Portugal)
|
2013/02 | Mitocondriotropic derivatives based on the natural polyphenol caffeic acid as an way out for oxidative stress related diseases | IJUP13–6º Encontro de Jovens Investigadores da U. Porto–Porto
(Porto, Portugal)
|
2013/01 | Chromone: a valid scaffold in Medicinal Chemistry | 2nd Workshop on Medicinal Chemistry
(Porto)
|
2013/01 | Bridging the gap between nature and phenolic antioxidants | 2nd Workshop on Medicinal Chemistry
(Porto, Portugal)
|
2013/01 | Development of Smart Carriers for delivering natural antioxidants to Mitochondria | 2nd Workshop on Medicinal Chemistry Drug Discovery and Development: Understanding the R&D process
(Porto, Portugal)
|
2013 | Caracterização do complexo de inclusão do fungicida pirimetanil com a 2-hidroxipropil-ß-ciclodextrina | XIX Encontro Galego-Português de Química
(Vigo, Spain)
|
2013 | Bridging the gap between nature and antioxidant therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold | IJUP13–6º Encontro de Jovens Investigadores da U. Porto
(Porto, Portugal)
|
2012 | Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage | V Encontro de Jovens Investigadores da UP (IJUP)–Porto
(Porto, Portugal)
|
2011/11 | Striving for success in antioxidant therapy | 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Roma, Italy)
|
2011/11 | New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants | 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Roma, Italy)
|
2011/10 | Toward the discovery of new lipophilic antioxidants based on cinnamic acid scaffold as mitochondria-directed neuroprotective agents | 2nd World Congress on Targeting Mitochondria
(Berlim, Germany)
|
2011 | Antioxidant therapy: in search of the magic bullet | 2nd World Congress on Targeting Mitochondria
(Berlim, Germany)
|
2010/05 | Chromones: a valid scaffold for the development of potent and selective MAO-B inhibitors | III European Workshop in Drug Synthesis
(Siena, Italy)
|
2010 | From nature to drug discovery: the chromone scaffold as a ‘privileged structure’ for the development of novel A3 receptor ligands | III EWDSy- Third European Workshop in Drug Synthesis
(Siena, Italy)
|
2009 | Searching for novel monoamine oxidase inhibitors based on chromone scaffold | XXVIII Meeting of Clinical Pharmacology and IX Meeting of Toxicology
(Porto, Portugal)
|
2009 | Adenosine receptor binding and neurotoxicity of novel chromone based ligands | XL Meeting of Portuguese Society of Pharmacology, XXVIII Meeting of Clinical Pharmacology and IX Meeting of Toxicology
(Porto, Portugal)
|
2008/04 | Metabolic Toxicology: from Synthesis to (Bio)analysis | International Courses on Toxicology, Cell and Molecular Toxicology Research Area, Centre for Neurosciences and Cell Biology
(Coimbra, Portugal)
|
2007/12 | Opening the Pandora box: The Syntab Contribution to the knowledge on the Toxic Effects of Drugs of Abuse and Their Metabolites | XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de Toxicologia
(Coimbra, Portugal)
|
2006/10 | Finding the Toxicophore: a Challenging Target in Medicinal Chemistry | Medicinal Chemistry in the 21st Century
(Lisboa, Portugal)
|
2005/10 | Phenolic Derivatives: A Study on the Relationship between Structure, Activity and Physicochemical Parameters | Anti-Inflammatory Drugs
(Paris, France)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2022/02 - 2022/07 | Descoberta e desenvolvimento de novos antibacterianos contra microrganismos multirresistentes
Co-supervisor
|
Química
Universidade do Porto Faculdade de Ciências, Portugal
|
2021/02 - 2021/07 | síntese de novos antimicrobianos baseados em produtos naturais
Co-supervisor
|
Química (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
|
2020/01/03 - 2020/07 | Síntese de novos antimicrobianos baseados em produtos naturais
Co-supervisor
|
Quimica (Degree) |
2020/01 - 2020/06 | Desenvolvimento de novos antibióticos baseados em modelos naturais
Supervisor
|
Projecto extracurricular (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
|
2020/01 - 2020/06 | Desenvolvimento de novos antibióticos baseados em modelos naturais
Supervisor
|
Projecto extracurricular (Degree) |
2019/01 - 2019/09 | Desenvolvimento de novos agentes antimicrobianos baseados em modelos naturais
Co-supervisor
|
Quimica (Degree) |
2017 - 2019 | Design and synthesis of chromone like derivatives as multitarget ligands: for neurodegeneratives diseases
Co-supervisor
|
Doutoramento (PhD)
University “Magna Græcia, Italy
|
2016 - 2016 | Evaluation of antioxidant activity of natural extracts
Co-supervisor
|
Doutoramento (PhD)
Università degli Studi di Cagliari, Italy
|
2014 - 2014 | Synthesis, Purification, characterization of Hydroxytirosol, Adenosine and lipoic acid derivatives and evaluation of their
antioxidant profile
Co-supervisor
|
Doutoramento (PhD)
Università degli Studi di Milano, Italy
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2017/10/14 - Current | Member of the organizing committee of the CIQUP’s workshop meeting (2017/10/17)
Meeting (Member of the Organising Committee)
|
Universidade do Porto Centro de Investigação em Química, Portugal |
2018/07/12 - 2018/07/14 | Member of the organizing committee VIII Meeting of the Paul Ehrlich EuroPhD Network (2018/07/12 - 2018/07/14)
Congress (Member of the Organising Committee)
|
Universidade do Porto Faculdade de Ciências, Portugal |
2017/09/22 - 2017/09/24 | Member of the organizing committee of the EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint annual meeting :A bridge
between EpiChemBio and MuTaLig COST Actions (2017/09/22)
Congress (Member of the Organising Committee)
|
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal |
2016/06/29 - 2016/07/01 | Member of the Local Organizing Committee of the 10th World Congress on Polyphenols Applications (2016/06/29)
Congress (Member of the Organising Committee)
|
Instituto Politécnico do Porto, Portugal |
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2022/02/11 | Efeito de Chalconas em Células da Granulosa
(Thesis) Arguer
|
Ruben Lourenço Seixas (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
|
2019/07/18 | Repurposing non-antibiotic drugs for antimicrobial purposes
(Thesis) Main arguer
|
Cláudia Cristina Moreira Leão (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
|
2019/07/10 | Desenvolvimento de novos antioxidantes para o tratamento da doença de Alzheimer
(Thesis) Main arguer
|
Cláudia Sofia Ferreira Pinto (Other)
Universidade do Porto Faculdade de Ciências, Portugal
|
2018/07/07 | The use of phytochemicals with EDTA as catheter lock solutions
(Thesis) Main arguer
|
João Pedro Rocha Vale (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
|
2018/04/26 | Single and multi-target agents for neurodegenerative diseases based on the chromone scaffold”
(Thesis) Arguer
|
Joana Alexandra Costa Reis (PhD)
Faculdade de Ciencias Universidade do Porto, Portugal
|
2017/07/13 | Síntese de derivados de piperazine com atividade inibitória da acetilcolinesterase como possível tratamento da Doenças de
Alzheimer
(Thesis) Main arguer
|
Tânia Catarina Pinto Moura (Other)
Universidade do Porto Faculdade de Ciências, Portugal
|
2017/07/07 | Análisis y predicciones teóricas en medicamentos y alimentos
(Thesis) Main arguer
|
Estela Guardado Yordi (PhD)
Universidade de Santiago de Compostela Departamento de Farmacoloxía Farmacia e Tecnoloxía Farmacéutica, Spain
|
2016/07/26 | Desenvolvimento de novos antioxidantes tendo como base modelos naturais
(Thesis) Main arguer
|
Mariana Fontoura da Fonseca Tavares Nogueira (Other)
Universidade do Porto Faculdade de Ciências, Portugal
|
Association member
Society Organization name | Role | |
---|---|---|
2016/04/18 - 2020/04/17 | COST Action AGA-CA15135-1(MuTaLig) | MC substitute member |
Committee member
Activity description Role |
Institution / Organization | |
---|---|---|
2022 - 2022/09 | Guest editor Special Issue "In Honor of Prof. Dr. Fernanda Borges’s Contribution"
Member
|
|
2020 - 2021/01/31 | Guest Editor of Special Issue "New Insights into Antimicrobial Drug Discovery"
Member
|
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2014 - Current | Advances Methods in Structural Analysis | Quimica e bioquimica (Mestrado) | Universidade do Porto Faculdade de Ciências, Portugal |
2014 - Current | Métodos Avançados de análise estrutural | (Mestrado) | Universidade do Porto Faculdade de Ciências, Portugal |
Journal scientific committee
Journal title (ISSN) | Publisher | |
---|---|---|
2018 - Current | Current Medicinal Chemistry | Bentham Science |
2017 - Current | MedChemComm | RSC Publishing |
2016 - Current | Biofouling | Taylor & Francis Online |
2015 - Current | European Journal of Medicinal Chemistry | Elsevier |
Distinctions
Award
2020 | best oral communication" Mapping the chromone-3-phenylcarboxamide pharmacophore: structure-activity-cytotoxicity and efflux
transport studies"
4th WG meeting – MuTaLig COST Action – Final stutus of WG meeting, Turkey
|
Other distinction
2014 | Paul Ehrlich MedChem Euro-PhD award |
2013 | III Escuela de Verano de la SEQT “Medicinal Chemistry in Drug Discovery: The Pharma Perspective |
2013 | Top-10 most cited articles for the article “Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors” J. Med. Chem., 54 (14), 5165-5173. |
2012 | ADDF Young Investigator Scholarship |
2011 | Prémio Provincial al trabajo |
2006 | Prémio da Spectro para melhor comunicação científica |