Alexandra Maria Neves Gaspar (1A19-6480-E6F1)

Curriculum Vitae

Alexandra Maria Neves Gaspar

I started my scientific career deeply engaged with drug discovery and with the development of innovative synthetic strategies and procedures to obtain concise and diverse-orientated chemical libraries based on natural products. The obtained libraries were screened toward several biological targets to develop enzymatic inhibitors and ligands of adenosine receptors aiming the discovery and development of new drug candidates to address multifactorial diseases such as cancer and neurodegenerative diseases. In addition, when required, I have performed the antioxidant evaluation of diverse system. Over the years I have been genuinely engaged in acquiring and developing a vast number of skills in the field of medicinal chemistry, allowing me to be aware of the importance of its transdisciplinary research and of the tools that are involved in the daily routine of the multidisciplinary R&D projects and of the overall process inherent to drug discovery and development. Currently, My research is focused on the design and development of new antimicrobial drugs based on naturally-occurring privileged structures. In this context, I collaborate with LEPABE in the group of Prof. Manuel Simões, to improve my skills in the area, and I establish an international collaboration with CO-ADD (Community for Open Antimicrobial Drug Discovery). At present more than 50 compounds were screened against several antibacterial and antifungal strains.

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Identification

Personal identification

Full name: Alexandra Maria Neves Gaspar

Citation names

Gaspar, Alexandra

Author identifiers

Ciência ID: 1A19-6480-E6F1
ORCID iD: 0000-0002-3892-4124

Email addresses

alexandra.gaspar@fc.up.pt (Professional)

Addresses

CIQ. Rua Campo Alegre, 4169-007, Porto, Porto, Portugal (Professional)

Websites

https://drugdiscoveryup.pt (Professional)

Knowledge fields

Exact Sciences - Chemical Sciences
Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)

Education

	Degree	Classification
2009/03/01 - 2013/12/09 Concluded	Química (Doutoramento) Major in Química Medicinal Universidade do Porto Faculdade de Ciências, Portugal "Chromone as a privileged scaffold in medicinal chemistry" (THESIS/DISSERTATION)	Aprovado com distinção
2013/12/09 Concluded	Química (Doutoramento) Major in Sem especialidade Universidade do Porto Faculdade de Ciências, Portugal "Chromone: a valid scaffold in Medicinal Chemistry " (THESIS/DISSERTATION)
2004 - 2007 Concluded	Controlo de Qualidade e Toxicologia dos Alimentos (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal	18
2004 - 2005 Concluded	Controlo da Qualidade e Toxicologia dos Alimentos (Especialização pós-licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal	17
1996 - 2002 Concluded	Ciências Farmacêuticas (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal	12

Affiliation

Science

	Category Host institution	Employer
2019/01/15 - Current	Contracted Researcher (Research)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2014/03/01 - 2019/01/14	Postdoc (Research)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2018/09/01 - 2018/11/30	Visiting Researcher (Research)	Università degli Studi di Cagliari, Italy

Teaching in Higher Education

	Category Host institution	Employer
2010/10/01 - 2011/02/28	Assistant (University Teacher)	Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
	Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2007/10/09 - 2007/12/31	Assistant (Polytechnic Teacher)	ETGI-AESBUC (Associação para a Escola Superior de Biotecnologia da Universidade Católica), Portugal

Others

	Category Host institution	Employer
2019/09/01 - 2025/01/05	Colaboração à Docência	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2017/04/02 - 2017/07/30	Investigador Visitante	Universidade de Santiago de Compostela, Spain

Projects

Grant

	Designation	Funders
2014/03/01 - 2019/01/14	NEW DRUGS TO TACKLE SUPERBUGS: A RATIONAL DRUG DISCOVERY APPROACH FOR THE DEVELOPMENT OF NEW ANTI-TUBERCULOSIS AGENTS SFRH/BPD/93331/2013	Fundação para a Ciência e a Tecnologia Concluded
2009/08/01 - 2013/07/31	NEW THERAPEUTIC APROACHES IN CANCER:DESIGN AND SYNTHESIS OF NEW A3 RECEPTOR LIGANDS SFRH/BD/43531/2008 Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2018 - Current	Development of centrally-active and safe catechol O-methyltransferase inhibitors POCI-01-0145-FEDER-029164 Researcher	Associação para a Inovação e Desenvolvimento da FCT
2018 - Current	Development of new antibiotics for aquaculture POCI-01-0145-FEDER-028397 Researcher Universidade do Porto Centro de Investigação em Química, Portugal	Ongoing
2016 - Current	Sustainable advanced materials NORTE-01-0145-FEDER-000028 Researcher Universidade do Porto Centro de Investigação em Química, Portugal	Concluded
2014 - Current	Development of Functional Materials NORTE-07-0124-FEDER-000065 Researcher Universidade do Porto Centro de Investigação em Química, Portugal	Concluded
2021/01/01 - 2025/12/31	Instituto de Ciências Moleculares LA/P/0056/2020 10.54499/LA/P/0056/2020 Universidade de Lisboa Centro de Química Estrutural, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade do Porto Centro de Investigação em Química, Portugal FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal Universidade de Coimbra, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/15 - 2025/01/14	Não Disponível DL 57/2016/CP1454/CT0008 10.54499/DL57/2016/CP1454/CT0008 Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/02 - 2023/07/01	A estratégia do Cavalo de Troia para o desenvolvimento de antibacterianos contra microrganismos multirresistentes EXPL/MED-QUI/1156/2021 10.54499/EXPL/MED-QUI/1156/2021 Principal investigator Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/26 - 2022/05/25	Desenvolvimento de inibidores da catecol O-metiltransferase de acção central sem risco de hepatotoxicidade PTDC/MED-QUI/29164/2017 Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Centro de Investigação em Química da Universidade do Porto UID/QUI/00081/2019 Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/20 - 2014	BP4Brain - Benzopyrane as a privileged structure for the rational design of multi-target-directed drugs potentially useful in neurodegenerative diseases info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113687/PT PTDC/QUI-QUI/113687/2009 Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal Universidade de Santiago de Compostela Facultade de Farmacia, Spain Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Projecto Estratégico - UI 81 - 2011-2012 PEst-C/QUI/UI0081/2011 Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/03/31	Novas abordagens terapêuticas no cancro: desenho racional e síntese de novos ligandos dos receptores A3 da adenosina PTDC/QUI/70359/2006 Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade de Coimbra, Portugal Universidade do Porto Faculdade de Farmácia, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2011	Rational design and synthesis of new adenosine A3 receptor ligands PTDC/QUI/70359/2006 Research Fellow Universidade do Porto Faculdade de Farmácia, Portugal	Concluded
2005/10/15 - 2007/04/15	Desenvolvimento de Novos Agentes Anticancerígenos: Derivados Fenólicos de Origem Natural ou Sintética - Relações Estrutura-Actividade POCI/QUI/55631/2004 Universidade de Coimbra, Portugal Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal Universidade do Porto Faculdade de Farmácia, Portugal Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Gaspar, Alexandra. "Synthesis of p-conjugated systems using formylchromone as building block". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. 2016. Published Gaspar, Alexandra. "Synthesis of 7-methoxy-4-oxo- N-phenyl- 4H-chromene-2-carboxamide". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. Royal Chemical Society, 2016. Published Gaspar, Alexandra. "Molecular Physicochemistry- a Tool for the Rational Development of New Antioxidants". In New Strides in Biotechnology. 2008.
Conference abstract	Gaspar, Alexandra. "Chromone as a privileged structure for lead optimization of new adenosine receptors ligands". Paper presented in Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, 2014. 10.1007/s11302-014-9430-7 Volpini, Rosaria; Lambertucci, Catia; Taffi, Sara; Vittori, Sauro; Klotz, Karl-Norbert; Cristalli, Gloria. "A3 adenosine receptors: Synthesis and biological evaluation of new potent and selective ligands". Paper presented in Purinergic Signalling (2014) 10:657–854- International Conference on Nucleotides, Nucleosides and Nucleobases, Bonn, 2014. 10.1135/css200507297 Gaspar, Alexandra. "Surpassing the Pharmacokinetic Drawbacks of Natural Phenolic Antioxidants". Paper presented in XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012. Published Gaspar, Alexandra. "Benzopyrone as a privileged scaffold for drug discovery: synthesis and structure–affinity relationships for adenosine receptors". Paper presented in ChemMedChem ISMC 2012 -XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012. Published Gaspar, Alexandra. "Discovery of a novel class of reversible monoamine oxidase B inhibitors based on chromone scaffold". Paper presented in ChemMedChem ISMC 2012-XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012. Published Borghesi, Marco. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Paper presented in ChemMedChem ISMC 2012-XXIInd International Symposium on Medicinal Chemistry, Berlim, 2012. Published Gaspar, Alexandra. "Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Paper presented in Free Radical Biology and Medicine-Society for Free Radical Research International 16th Biennial Meeting, Londres, 2012. Published • 10.1016/j.freeradbiomed.2012.08.213 Gaspar, Alexandra. "Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif". Paper presented in Purinergic Signalling volume 6, pages49–115(2010)-Third joint Italian-German Purine Club meeting: “Purinergic receptors: new frontiers for novel therapies”, Camerino, 2010. Published • https://doi.org/10.1007/s11302-009-9171-1 Cong, Chunyu; Sun, Pingping; Ma, Zhiqiang. "Predicting binding affinity using differential evolution". Paper presented in Purinergic Signalling (2010) -Third joint Italian-German Purine Club meeting: “Purinergic receptors: new frontiers for novel therapies”, Camerino, 2010. Published • 10.1007/s11302-009-9171-1 Boudreau, Michael. "Development of novel systems to deliver natural antioxidants to mitochondria: MitoCIN'S as a case study". Paper presented in 47th Annual Scientific Meeting of the European Society for Clinical Investigation,, Albufeira, 2007. 10.1109/sysose.2007.4304229
Conference poster	Gaspar, Alexandra. "A rational drug discovery approach for the design and development of new antimicrobial agents.". Paper presented in MuTaLig COST ACTION CA15135, 2020. Gaspar, Alexandra. "Evaluation of benzopyrone pharmacophore features on MAO-B inhibition". Paper presented in 26th Young Research Fellows meeting, 2019. Gaspar, Alexandra. "Design and Development of Dual -Target Ligands Based on Benzopyran for the Treatment of Parkinson’s Disease". Paper presented in 3rd Annual meeting - MuTaLig COST Action, 2018. Gaspar, Alexandra. "Mapping the Pharmacophore of Benzopyrone MAO-B Inhibitors". Paper presented in VIII Meeting of the Paul Ehrlich EuroPhD Network, 2018. Gaspar, Alexandra. "Development of new antimicrobial agents based on the chromone scaffold". Paper presented in VIII Meeting of the Paul Ehrlich EuroPhD Network, 2018. Gaspar, Alexandra. "Benzopyrane as a valid scaffold for the development of multitarget ligands for neurodegenerative diseases". Paper presented in 1st annual meeting – MuTaLig COST Action, 2016. Gaspar, Alexandra. "Search of new antibacterial compounds inspired on benzopyran scaffold". Paper presented in Meeting of the Paul Ehrlich Euro-PhD Network, 2015. Hugues, Edgar. "Development of new adenosine receptors ligands based on chromone scaffold: adventures in the design and optimization process". Paper presented in Meeting of the Paul Ehrlich Euro-PhD Network, 2015. Gaspar, Alexandra. "Development of A3 adenosine receptor ligands by an analogue-based approach". Paper presented in XXII Young Research Fellow Meeting, 2015. Gaspar, Alexandra. "Discovery of new leads for old targets: insights on the lead optimization process of a new MAO-B inhibitor based on chromone scaffold". Paper presented in 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network–Hradec Králové, República Checa, 2014. Gaspar, Alexandra. "“Chromone: a valid scaffold in medicinal chemistry". Paper presented in 4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network - Hradec Králové, Praga, República Checa, 2014. Gaspar, Alexandra. "MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria". Paper presented in 8th World Congress on Polyphenols Applications: ISANH Polyphenols - Lisboa, Portugal, 2014. Gaspar, Alexandra. "Remaking of Dietary Antioxidants: Targeting MitoBEN’s to Mitochondria as a New Therapeutic Strategy". Paper presented in 10º Portuguese National Meeting of Organic Chemistry – 1st Portuguese– Brazilian Organic Chemistry Symposium–, 2013. Gaspar, Alexandra. "Targeted Delivery of MitoCIN’S: a New Therapeutic Approach for Oxidative Stress Related Diseases". Paper presented in 10º Portuguese National Meeting of Organic Chemistry – 1st Portuguese– Brazilian Organic Chemistry Symposium–, 2013. Gaspar, Alexandra. "Nature-Inspired Artwoark: Development of 6-(Heteroaryl/Aryl) Chromones as Novel Adenosine Receptor Ligands". Paper presented in III SEQT Summer School – Medicinal Chemistry in Drug Discovery: The Pharma Perspective–Madrid, Espanha,, 2013. Gaspar, Alexandra. "Development of new dual-target strategy for the discovery of new anti-Parkinson drugs". Paper presented in III SEQT Summer School – Medicinal Chemistry in Drug Discovery: The Pharma Perspective–Madrid, Espanha,, 2013. Gaspar, Alexandra. "Development of new dual-target MAO-B/AChE inhibitors based on chromone derivatives". Paper presented in Frontiers in Medicinal Chemistry–São Francisco, Califórnia, EUA,, 2013. Chavarria, Daniel; Cagide, Fernando; Gaspar, Alexandra; Borges, Fernanda. "Microwave Organic Reactions Applied to the Synthesis of Novel Monoamine Oxidase Inhibitors". Paper presented in V Encontro de Jovens Investigadores da UP (IJUP), 2012. Gaspar, Alexandra. "Parkinson disease and non-dopaminergic therapy: synthesis and evaluation of new adenosine receptors antagonists based on benzo-¿-pyrone scaffold". Paper presented in 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs–Nova Iorque, EUA, 2012. Gaspar, Alexandra. "Modulating the pharmacokinetic profile of natural phenolic antioxidants with potential neuroprotective activity". Paper presented in 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs–Nova Iorque, EUA, 2012. Gaspar, Alexandra. "Mitochondria-Targeted Cinnamic Antioxidants: Novel Promising Drugs for Treatment of Alzheimer Disease". Paper presented in 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs–Nova Iorque, EUA, 2012. Gaspar, Alexandra. "New therapeutic approaches towards neurodegenerative diseases: targeting oxidative damage with innovative lipophilic antioxidants". Paper presented in 16th RSC_SCI Cambridge Medicinal Chemistry Symposium–Cambridge, Reino Unido, 2011. Gaspar, Alexandra. "Drug discovery for neurodegenerative diseases: development of novel potent and selective chromone based MAO-B inhibitors". Paper presented in 16th RSC_SCI Cambridge Medicinal Chemistry Symposium–Cambridge, Reino Unido, 2011. Gaspar, Alexandra. "Benzo-¿-pyrone based ligands as a privileged scaffold for drug discovery: synthesis and structure-affinity relationships for adenosines rece". Paper presented in 16th RSC_SCI Cambridge Medicinal Chemistry Symposium–Cambridge, Reino Unido, 2011. Gaspar, Alexandra. "New mitochondria-targeted antioxidants based on cinnamic scaffold for neurodegenerative disease therapy". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal,, 2011. Gaspar, Alexandra. "Chromone-based adenosine receptor ligands: a new challenge in the anticancer drug discovery scenario". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011. Gaspar, Alexandra. "Targeting phenolic antioxidants to mitochondria: synthesis and characterization of novel triphenylphosphonium-conjugated lipophilic cinnamic derivatives". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, 2011. Gaspar, Alexandra. "Design and development of a novel chemical library, based on a privileged scaffold, suitable to speed up the drug discovery process of IMAO-B”". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, 2011. Gaspar, Alexandra. "Accelerating lead optimization of MAO inhibitors throughout microwaveassisted organic synthesis". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011. Leferink, Frank; Blaj, Alex; Hogeman, Edwin; Storck, Rob. "Using preloading to protect bearings against lightning damage". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011. 10.1109/sipda.2015.7339301 Gaspar, Alexandra. "Development of novel lipophilic antioxidants based on ferulic acid". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011. Rivero, Ralph A.; Hardwicke, Mary Ann. "Abstract 2913: Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Ka) for the treatment of PTEN deficient tumors". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry–Porto, Portugal, 2011. 10.1158/1538-7445.am2012-2913 Sonoda, Kenzo. "Abstract C256: New therapeutic modalities by targeting RCAS1 which induces apoptosisviaectodomain shedding mediated by ADAM9". Paper presented in Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies–Barcelona, Espanha, 2009. 10.1158/1535-7163.targ-09-c256 Gaspar, Alexandra. "QSAR model for predicting binding affinity to adenosine A2b receptors of antagonists based on chromone scaffold". Paper presented in Third Joint Italian–German Purine Club Meeting Purinergic Receptors: New Frontiers for Novel Therapies–Camerino, Itália, 2009. Gaspar, Alexandra. "From nature to drug discovery: the chromone scaffold as a privileged structure¿ for the development of novel A3 receptor ligands". Paper presented in III EWDSy–Third European Workshop in Drug Synthesis, University of Siena– Siena, Itália,, 2009. Gaspar, Alexandra. "Biological activity of novel esters structurally based on a natural phenolic acid model". Paper presented in Metabolic Toxicology: from Pathway to Organism – International Courses on Toxicology, Cell and Molecular Toxicology Research Area, Centre for Neurosciences and Cell Biology of the University of Coimbra–Coimbra, Portugal, 2008. Gaspar, Alexandra. "Phenolic Alkyl Esters with Potential Anticancer Activity: A Raman Spectroscopy Study in the Solid State". Paper presented in 12th European Conference on the Spectroscopy of Biological Molecules (ECSBM–12)–Bobigny, Paris, França, 2007. Gaspar, Alexandra. "Phenolic Esters with Potential Anticancer Activity: Solution Equilibria Studied by Raman Spectroscopy". Paper presented in 12th European Conference on the Spectroscopy of Biological Molecules (ECSBM–12)–Bobigny, Paris, Franç, 2007. Gaspar, Alexandra. "Therapeutic anti-inflammatory strategies based on targeting adenosine receptors". Paper presented in International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC07)–St. Petersburgo, Rússia, 2007. Gaspar, Alexandra. "Novel Therapeutic approaches in cancer: design and synthesis of new adenosine A3 Receptor ligands". Paper presented in First Iberic Meeting on Medicinal Chemistry–anticancer agents–Régua, Portugal, 2007. Gaspar, Alexandra. "New insights in the therapeutic value of hydroxyl cinnamic derivatives: cytotoxic and COX-2 inhibition properties". Paper presented in First Iberic Meeting on Medicinal Chemistry–anticancer agents–Régua, Portugal, 2007. Gaspar, Alexandra; Machado, N.F.L.; Calheiros, R.; Fiuza, S.M.; Borges, F.; Gaspar, A.; Garrido, J.; Marques, M.P.. "Phenolic esters with potential anticancer activity the structural Variable". Paper presented in First Iberic Meeting on Medicinal Chemistry–anticancer agents–Régua, Portugal, 2007. 10.1007/s00894-007-0174-y Gaspar, Alexandra. "Alkyl Phenolic Esters – A Raman Spectroscopy Study". Paper presented in IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha,, 2006. Gaspar, Alexandra. "New Potential Nonsteroidal Aromatase Inhibitors: A Raman Spectroscopy Study". Paper presented in IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha, 2006. Gaspar, Alexandra. "Structural Elucidation of New Potential Selective A2A Adenosine Receptor Agonists by Raman Spectroscopy". Paper presented in IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha, 2006. Gaspar, Alexandra. "Spectroscopic Studies on Hydroxycinnamic Acid Derivatives as Potential Antiinflammatory Agents". Paper presented in IV CIE (IV Congresso Ibérico de Espectroscopia/XX Reunión Española de Espectroscopía)–Ciudad Real, Espanha, 2006. Gaspar, Alexandra. "Design and Synthesis of Novel Hydroxycinnamic Derivatives with Cytotoxic, Antioxidant and Anti-inflammatory Activities". Paper presented in 3rd International Conference on Oxidative Stress in Skin Medicine and Biology– Andros, Grécia,, 2006. Gaspar, Alexandra. "Phenolic Derivatives as Potential Anticancer Agents". Paper presented in 3rd International Conference on Oxidative Stress in Skin Medicine and Biology– Andros, Grécia, 2006. Gaspar, Alexandra. "Anticancer and Anti-inflammatory Properties of Hydroxycinnamic Derivatives". Paper presented in XXIII International Conference on Polyphenols, 2006. Gaspar, Alexandra. "Evaluation of anti-inflammatory and anti-cancer properties of synthetic hydroxycinnamic derivatives". Paper presented in 66th Intern. Pharm. Fed. Congress–Salvador Bahia, Brasil, 2006. Gaspar, Alexandra. "Synthesis of Novel Chromone Derivatives as Potential Lypophilic Antioxidants". Paper presented in International Symposium on Chemistry, Biology and Medicine–, 2006. Gaspar, Alexandra. "Enzymatic and non-enzymatic synthesis of glutathionil conjugates of cinnamic acids: an experimental and theorical study". Paper presented in International Symposium on Chemistry, Biology and Medicine, 2006. Gaspar, Alexandra. "Synthesis of promising antioxidant agents structurally based on cinnamic acid". Paper presented in International Symposium on Chemistry, Biology and Medicine, 2006. Gaspar, Alexandra. "Antioxidant versus Anticancer/Anti-inflammatory Properties of Phenolic Derivatives: A New Challenge on Structure-Activity Studies". Paper presented in Paris Anti–Inflammatory Drugs, 2005.
Journal article	Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Maruca, Annalisa; Rocca, Roberta; Gil Martins, Eva; Barreiro, Sandra; et al. Corresponding author: Gaspar, Alexandra. "Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?". Journal of Medicinal Chemistry 64 15 (2021): 11169-11182. http://dx.doi.org/10.1021/acs.jmedchem.1c00510. 10.1021/acs.jmedchem.1c00510 Francesco Mesiti; Annalisa Maruca; Vera Silva; Roberta Rocca; Carlos Fernandes; Fernando Remião; Eugenio Uriarte; et al. Corresponding author: Alexandra Gaspar. "4-Oxoquinolines and monoamine oxidase: When tautomerism matters". European Journal of Medicinal Chemistry (2021): 113183-113183. https://doi.org/10.1016/j.ejmech.2021.113183. 10.1016/j.ejmech.2021.113183 Gomes, Ligia R.; Low, John Nicolson; Borges, Fernanda; Gaspar, Alexandra; Mesiti, Francesco. "The synthesis, crystal structure and Hirshfeld analysis of 4-(3,4-dimethylanilino)-N-(3,4-dimethylphenyl)quinoline-3-carboxamide". Acta Crystallographica Section E Crystallographic Communications 76 2 (2020): 201-207. http://dx.doi.org/10.1107/s2056989020000298. 10.1107/s2056989020000298 Mesiti, Francesco; Chavarria, Daniel; Gaspar, Alexandra; Alcaro, Stefano; Borges, Fernanda. Corresponding author: Gaspar, Alexandra. "The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease". European Journal of Medicinal Chemistry 181 (2019): 111572. http://dx.doi.org/10.1016/j.ejmech.2019.111572. Published • 10.1016/j.ejmech.2019.111572 Gaspar, A.; Mohabbati, M.; Cagide, F.; Razzaghi-Asl, N.; Miri, R.; Firuzi, O.; Borges, F.. "Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds". Research in Pharmaceutical Sciences 14 1 (2019): 74-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061659825&partnerID=MN8TOARS. 10.4103/1735-5362.251855 Oliveira, C.; Gaspar, A.; Gomes, L.R.; Low, J.N.; Borges, F.; Cagide, F.. "Structural elucidation of a series of benzamide derivatives". Magnetic Resonance in Chemistry 56 3 (2018): 216-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037652503&partnerID=MN8TOARS. 10.1002/mrc.4682 Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Correction to: Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors (Journal of Medicinal Chemistry (2016) 59 (5879-5893) DOI: 10.1021/acs.jmedchem.6b00527)". Journal of Medicinal Chemistry 61 11 (2018): 5054-5054. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048642711&partnerID=MN8TOARS. 10.1021/acs.jmedchem.8b00600 Reis, J.; Gaspar, A.; Milhazes, N.; Borges, F.. "Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances". Journal of Medicinal Chemistry 60 19 (2017): 7941-7957. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031293351&partnerID=MN8TOARS. 10.1021/acs.jmedchem.6b01720 Low, J.N.; Gomes, L.R.; Gaspar, A.; Borges, F.. "Structure of 7-hydroxy-3-(2-methoxyphenyl)-2-trifluoromethyl-4H-chromen-4-one". Acta Crystallographica Section E: Crystallographic Communications 73 (2017): 1130-1134. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029517534&partnerID=MN8TOARS. 10.1107/S2056989017009896 Borges, A.; Sousa, P.; Gaspar, A.; Vilar, S.; Borges, F.; Simões, M.. "Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes". Biofouling 33 2 (2017): 156-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011301293&partnerID=MN8TOARS. 10.1080/08927014.2017.1280732 Fonseca, A.; Gaspar, A.; Matos, M.J.; Gomes, L.R.; Low, J.N.; Uriarte, E.; Borges, F.. "Structural elucidation of a series of 6-methyl-3-carboxamidocoumarins". Magnetic Resonance in Chemistry 55 4 (2017): 373-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-85000471196&partnerID=MN8TOARS. 10.1002/mrc.4541 Cagide, F.; Reis, J.; Gaspar, A.; Chavarria, D.; Kachler, S.; Klotz, K.N.; Gomes, L.R.; et al. "Discovery of the first A1 adenosine receptor ligand based on the chromone scaffold". RSC Advances 6 52 (2016): 46972-46976. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969939884&partnerID=MN8TOARS. 10.1039/c6ra02347a Oliveira, J.A.S.A.; Oliveira, T.S.M.; Gaspar, A.; Borges, F.; Ribeiro da Silva, M.D.M.C.; Monte, M.J.S.. "Study on the volatility of halogenated fluorenes". Chemosphere 157 (2016): 25-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968830414&partnerID=MN8TOARS. 10.1016/j.chemosphere.2016.05.014 Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors". Journal of Medicinal Chemistry 59 12 (2016): 5879-5893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975871993&partnerID=MN8TOARS. 10.1021/acs.jmedchem.6b00527 Gonçalves, A.L.; Abreu, A.C.; Coqueiro, A.; Gaspar, A.; Borges, F.; Choi, Y.H.; Pires, J.C.M.; Simões, M.. "Co-cultivation of Synechocystis salina and Pseudokirchneriella subcapitata under varying phosphorus concentrations evidences an allelopathic competition scenario". RSC Advances 6 61 (2016): 56091-56100. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975041703&partnerID=MN8TOARS. 10.1039/c6ra07771d Fernandes, C.; Soares, P.; Gaspar, A.; Martins, D.; Gomes, L.R.; Low, J.N.; Borges, F.. "Synthesis of 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester derivatives". Tetrahedron Letters 57 27-28 (2016): 3006-3010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973109330&partnerID=MN8TOARS. 10.1016/j.tetlet.2016.05.096 Gomes, L.R.; Low, J.N.; Fernandes, C.; Gaspar, A.; Borges, F.. "Crystal structures of ethyl 6-(4-methylphenyl)-4-oxo-4H-chromene-2-carboxylate and ethyl 6-(4-fluorophenyl)-4-oxo-4H-chromene-2-carboxylate". Acta Crystallographica Section E: Crystallographic Communications 72 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954144374&partnerID=MN8TOARS. 10.1107/S2056989015022781 Cagide, F.; Silva, T.; Reis, J.; Gaspar, A.; Borges, F.; Gomes, L.R.; Low, J.N.. "Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry". Chemical Communications 51 14 (2015): 2832-2835. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922432422&partnerID=MN8TOARS. 10.1039/c4cc08798d Gaspar, A.; Milhazes, N.; Santana, L.; Uriarte, E.; Borges, F.; Matos, M.J.. "Oxidative stress and neurodegenerative diseases: Looking for a therapeutic solution inspired on benzopyran chemistry". Current Topics in Medicinal Chemistry 15 5 (2015): 432-445. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930908241&partnerID=MN8TOARS. Cagide, F.; Gaspar, A.; Reis, J.; Chavarria, D.; Vilar, S.; Hripcsak, G.; Uriarte, E.; et al. "Navigating in chromone chemical space: Discovery of novel and distinct A3 adenosine receptor ligands". RSC Advances 5 96 (2015): 78572-78585. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942156288&partnerID=MN8TOARS. 10.1039/c5ra14988f Gomes, L.R.; Low, J.N.; Cagide, F.; Gaspar, A.; Borges, F.. "A comparison of the structures of some 2- and 3-substituted chromone derivatives: A structural study on the importance of the secondary carboxamide backbone for the inhibitory activity of MAO-B". Acta Crystallographica Section E: Crystallographic Communications 71 (2015): 1270-1277. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948458262&partnerID=MN8TOARS. 10.1107/S2056989015017958 Reis, J.; Gaspar, A.; Borges, F.; Rebelo Gomes, L.; Low, J.N.. "Synthesis, spectroscopic characterization and X-ray structure of novel 7-methoxy-4-oxo-N-phenyl-4H-chromene-2-carboxamides". Journal of Molecular Structure 1056-1057 1 (2014): 31-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886478757&partnerID=MN8TOARS. 10.1016/j.molstruc.2013.09.024 Gaspar, A.; Matos, M.J.; Garrido, J.; Uriarte, E.; Borges, F.. "Chromone: A valid scaffold in medicinal chemistry". Chemical Reviews 114 9 (2014): 4960-4992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900440197&partnerID=MN8TOARS. 10.1021/cr400265z Fernandes, C.; Encarnação, I.; Gaspar, A.; Garrido, J.; Borges, F.; Garrido, E.M.. "Influence of hydroxypropyl- ß -cyclodextrin on the photostability of fungicide pyrimethanil". International Journal of Photoenergy 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84897555260&partnerID=MN8TOARS. 10.1155/2014/489873 Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F.. "Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids". European Journal of Medicinal Chemistry 62 (2013): 289-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030904&partnerID=MN8TOARS. 10.1016/j.ejmech.2012.12.049 Helguera, A.M.; Pérez-Garrido, A.; Gaspar, A.; Reis, J.; Cagide, F.; Vina, D.; Cordeiro, M.N.D.S.; Borges, F.. "Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors". European Journal of Medicinal Chemistry 59 (2013): 75-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870213017&partnerID=MN8TOARS. 10.1016/j.ejmech.2012.10.035 Gomes, L.R.; Low, J.N.; Cagide, F.; Gaspar, A.; Reis, J.; Borges, F.. "Structural characterization of some N-phenyl-4-oxo-4H-2-chromone carboxamides". Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials 69 3 (2013): 294-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881167454&partnerID=MN8TOARS. 10.1107/S2052519213009676 Teixeira, J.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F.. "Hydroxycinnamic acid antioxidants: An electrochemical overview". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84881540701&partnerID=MN8TOARS. 10.1155/2013/251754 Gaspar, A.; Cagide, F.; Quezada, E.; Reis, J.; Uriarte, E.; Borges, F.. "Synthesis and NMR studies of novel chromone-2-carboxamide derivatives". Magnetic Resonance in Chemistry 51 4 (2013): 251-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254988&partnerID=MN8TOARS. 10.1002/mrc.3937 Matos, M.J.; Hogger, V.; Gaspar, A.; Kachler, S.; Borges, F.; Uriarte, E.; Santana, L.; Klotz, K.-N.. "Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins". Journal of Pharmacy and Pharmacology 65 11 (2013): 1590-1597. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886085159&partnerID=MN8TOARS. 10.1111/jphp.12135 Matos, M.J.; Gaspar, A.; Kachler, S.; Klotz, K.-N.; Borges, F.; Santana, L.; Uriarte, E.. "Targeting adenosine receptors with coumarins: Synthesis and binding activities of amide and carbamate derivatives". Journal of Pharmacy and Pharmacology 65 1 (2013): 30-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870870474&partnerID=MN8TOARS. 10.1111/j.2042-7158.2012.01571.x Reis, J.; Gaspar, A.; Borges, F.; Gomes, L.R.; Low, J.N.. "4-Oxo-N-phenyl-4H-chromene-2-carboxamide and of a new polymorph of 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide and its hemihydrate". Acta Crystallographica Section C: Crystal Structure Communications 69 12 (2013): 1527-1533. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890072345&partnerID=MN8TOARS. 10.1107/S0108270113029727 Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold". Free Radical Research 46 5 (2012): 600-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS. 10.3109/10715762.2012.662593 Gaspar, A.; Reis, J.; Matos, M.J.; Uriarte, E.; Borges, F.. "In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-¿-pyrone skeleton". European Journal of Medicinal Chemistry 54 (2012): 914-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864409949&partnerID=MN8TOARS. 10.1016/j.ejmech.2012.05.033 Garrido, J.; Gaspar, A.; Garrido, E.M.; Miri, R.; Tavakkoli, M.; Pourali, S.; Saso, L.; Borges, F.; Firuzi, O.. "Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress". Biochimie 94 4 (2012): 961-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857454548&partnerID=MN8TOARS. 10.1016/j.biochi.2011.12.015 Matos, M.J.; Gaspar, A.; Borges, F.; Uriarte, E.; Santana, L.. "Improved synthesis of 3-(aminoaryl)coumarins". Organic Preparations and Procedures International 44 6 (2012): 522-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870010404&partnerID=MN8TOARS. 10.1080/00304948.2012.730937 Gaspar, A.; Reis, J.; Kachler, S.; Paoletta, S.; Uriarte, E.; Klotz, K.-N.; Moro, S.; Borges, F.. "Discovery of novel A 3 adenosine receptor ligands based on chromone scaffold". Biochemical Pharmacology 84 1 (2012): 21-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860664996&partnerID=MN8TOARS. 10.1016/j.bcp.2012.03.007 Borges, F.; Reis, J.; Encarnação, I.; Gaspar, A.; Morales, A.; Milhazes, N.. "Parkinson's disease management. part iidiscovery of mao-b inhibitors based on nitrogen heterocycles and analogues". Current Topics in Medicinal Chemistry 12 20 (2012): 2116-2130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874913282&partnerID=MN8TOARS. Gaspar, A.; Reis, J.; Fonseca, A.; Milhazes, N.; Viña, D.; Uriarte, E.; Borges, F.. "Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors". Bioorganic and Medicinal Chemistry Letters 21 2 (2011): 707-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651257725&partnerID=MN8TOARS. 10.1016/j.bmcl.2010.11.128 Cagide, F.; Reis, J.; Gaspar, A.; Borges, F.. "Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis". Tetrahedron Letters 52 48 (2011): 6446-6449. http://www.scopus.com/inward/record.url?eid=2-s2.0-80255127537&partnerID=MN8TOARS. 10.1016/j.tetlet.2011.09.095 Menezes, J.C.J.M.D.S.; Kamat, S.P.; Cavaleiro, J.A.S.; Gaspar, A.; Garrido, J.; Borges, F.. "Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates". European Journal of Medicinal Chemistry 46 2 (2011): 773-777. http://www.scopus.com/inward/record.url?eid=2-s2.0-79151481300&partnerID=MN8TOARS. 10.1016/j.ejmech.2010.12.016 Gaspar, A.; Silva, T.; Yáñez, M.; Vina, D.; Orallo, F.; Ortuso, F.; Uriarte, E.; et al. "Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors". Journal of Medicinal Chemistry 54 14 (2011): 5165-5173. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960651250&partnerID=MN8TOARS. Published • 10.1021/jm2004267 Gaspar, A.; Teixeira, F.; Uriarte, E.; Milhazes, N.; Melo, A.; Cordeiro, M.N.D.S.; Ortuso, F.; Alcaro, S.; Borges, F.. "Towards the Discovery of a Novel Class of Monoamine Oxidase Inhibitors: Structure-Property-Activity and Docking Studies on Chromone Amides". ChemMedChem 6 4 (2011): 628-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066953&partnerID=MN8TOARS. 10.1002/cmdc.201000452 Gaspar, A.; Silva, T.; Borges, F.. "Adenosine a3 receptors: A new therapeutic approach in cancer,Receptores a3 da adenosina: uma nova abordagem terapêutica no câncer". Quimica Nova 34 8 (2011): 1417-1424. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054893720&partnerID=MN8TOARS. 10.1590/S0100-40422011000800022 Gaspar, A.; Martins, M.; Silva, P.; Garrido, E.M.; Garrido, J.; Firuzi, O.; Miri, R.; Saso, L.; Borges, F.. "Dietary phenolic acids and derivatives. Evaluation of the antioxidant activity of sinapic acid and its alkyl esters". Journal of Agricultural and Food Chemistry 58 21 (2010): 11273-11280. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149321255&partnerID=MN8TOARS. 10.1021/jf103075r Alcaro, S.; Gaspar, A.; Ortuso, F.; Milhazes, N.; Orallo, F.; Uriarte, E.; Yáñez, M.; Borges, F.. "Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B". Bioorganic and Medicinal Chemistry Letters 20 9 (2010): 2709-2712. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950954802&partnerID=MN8TOARS. 10.1016/j.bmcl.2010.03.081 Gaspar, A.; Garrido, E.M.; Esteves, M.; Quezada, E.; Milhazes, N.; Garrido, J.; Borges, F.. "New insights into the antioxidant activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives". European Journal of Medicinal Chemistry 44 5 (2009): 2092-2099. http://www.scopus.com/inward/record.url?eid=2-s2.0-62749186901&partnerID=MN8TOARS. 10.1016/j.ejmech.2008.10.027 Machado, N.F.L.; Calheiros, R.; Gaspar, A.; Garrido, J.; Borgesa, F.; Marques, M.P.M.. "Antioxidant phenolic esters with potential anticancer activity: Solution equilibria studied by Raman spectroscopy". Journal of Raman Spectroscopy 40 1 (2009): 80-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962407137&partnerID=MN8TOARS. 10.1002/jrs.2083 Esteves, M.; Siquet, C.; Gaspar, A.; Rio, V.; Sousa, J.B.; Reis, S.; Marques, M.P.M.; Borges, F.. "Antioxidant versus cytotoxic properties of hydroxycinnamic acid derivatives - A new paradigm in phenolic research". Archiv der Pharmazie 341 3 (2008): 164-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649198620&partnerID=MN8TOARS. 10.1002/ardp.200700168 Calheiros, R.; Machado, N.F.L.; Fiuza, S.M.; Gaspar, A.; Garrido, J.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "Antioxidant phenolic esters with potential anticancer activity: A Raman spectroscopy study". Journal of Raman Spectroscopy 39 1 (2008): 95-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549148538&partnerID=MN8TOARS. 10.1002/jrs.1822 Marques, M.P.M.; Borges, F.; Sousa, J.; Calheiros, R.; Garrido, J.; Gaspar, A.; Antunes, F.; Diniz, C.; Fresco, P.. "Cytotoxic and COX-2 inhibition properties of hydroxycinnamic derivatives". Letters in Drug Design and Discovery 3 5 (2006): 316-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745603707&partnerID=MN8TOARS. 10.2174/157018006777574212
Online resource	Gaspar, Alexandra. Multi-target Design, Synthesis and Study of a Selected Series of Carbamates and Esters with Coumarin Scaffold. 2016. http://www.sciforum.net/conf/ecsoc-16/. Gaspar, Alexandra; Matos, Maria; Olea-azar, Claudio; Perez-Cruz, Fernanda; Borges, Fernanda; Gaspar, Alexandra; Santana, Lourdes; Janeiro, Patricia. Insights into the antioxidant activity of phenolic compounds: Synthesis and electrochemical study of new series of hydroxycoumarins. 2015. http://www.sciforum.net/presentation/617. 10.3390/ecsoc-15-00617

Intellectual property

Patent

Gaspar, Alexandra. 2009. "Cromonas e derivados de cromonas com actividade inibidora da monoamina oxidase e aplicações terapêuticas relacionadas". Portugal.
Granted/Issued
Gaspar, Alexandra. 2008. "Novel chromone derivatives, methods of synthesis therefor and use as antioxidants/preservatives". Portugal.
Granted/Issued
Gaspar, Alexandra. 2007. "Novos derivados de cromonas, respectivo processo de síntese e sua utilização como antioxidantes/conservantes".
Granted/Issued

Other

Dataset

Gaspar, Alexandra. CCDC 939914: Experimental Crystal Structure Determination.
10.5517/cc10k1tf

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/11/24	Hijacking bacteria’s machinery to fight superbugs: synthesis and antibacterial evaluation of ciprofloxacin-siderophore conjugates	XXVII Encontro Galego-Portugués De Química (Porto, Portugal)
2022/11/17	Improving benzisothiazolinone (BIT) effectiveness by cyclodextrin’s encapsulation: Ecotoxicity and Antibacterial studies	XXVI Encontro Galego-Portugués De Química (Santiago de Compostela, Spain)
2021/02/12	The influence of 4-oxoquinoline tautomerism in the MAOs inhibition	28th Young Research Fellows Meeting Faculty of Pharmacy, University of Paris (Paris, France)
2020/03/05	Mapping the chromone-3-carboxamide pharmacophore: structure-activity-toxicity and efflux transport studies	4th WG meeting – MuTaLig COST Action – Final stutus of WG meeting Oral Faculty of Pharmacy - Ege University - Izmir - Turkey (Izmir, Turkey)
2019/06	Looking for the Pharmacophore of Benzopyran MAO-B Inhibitors	MedChem19 Catanzaro- IV annual COST ACTION CA15135 meeting/Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting, (Catanzaro, Italy)
2019/02	Design and development of new chemical entities for the treatment of Parkinson disease	MuTaLig COST ACTION CA15135 3rd WG meeting (Paris, France)
2018/05	Descoberta e desenvolvimento de novos antibacterianos contra bactérias multirresistentes	2ºEncontro Investigadores DQB-FCUP (Porto, Portugal)
2014/06	Chromone: a valid scaffold in medicinal chemistry	4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network (Cracóvia, Czech Republic)
2014/06	“MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria”	World Congress on Polyphenols Applications: ISANH Polyphenols 2014 (Lisboa, Portugal)
2013/09	Discovery of dual-target agents based on chromone scaffold for Parkinson´s disease	3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network (Calhari, Italy)
2013/04	Development of novel systems to delivery natural antioxidants to mitochondria: MitoCIN’s as a case study	47th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) (Albufeira, Portugal)
2013/02	Mitocondriotropic derivatives based on the natural polyphenol caffeic acid as an way out for oxidative stress related diseases	IJUP13–6º Encontro de Jovens Investigadores da U. Porto–Porto (Porto, Portugal)
2013/01	Chromone: a valid scaffold in Medicinal Chemistry	2nd Workshop on Medicinal Chemistry (Porto)
2013/01	Bridging the gap between nature and phenolic antioxidants	2nd Workshop on Medicinal Chemistry (Porto, Portugal)
2013/01	Development of Smart Carriers for delivering natural antioxidants to Mitochondria	2nd Workshop on Medicinal Chemistry Drug Discovery and Development: Understanding the R&D process (Porto, Portugal)
2013	Caracterização do complexo de inclusão do fungicida pirimetanil com a 2-hidroxipropil-ß-ciclodextrina	XIX Encontro Galego-Português de Química (Vigo, Spain)
2013	Bridging the gap between nature and antioxidant therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold	IJUP13–6º Encontro de Jovens Investigadores da U. Porto (Porto, Portugal)
2012	Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage	V Encontro de Jovens Investigadores da UP (IJUP)–Porto (Porto, Portugal)
2011/11	Striving for success in antioxidant therapy	10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants (Roma, Italy)
2011/11	New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants	10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants (Roma, Italy)
2011/10	Toward the discovery of new lipophilic antioxidants based on cinnamic acid scaffold as mitochondria-directed neuroprotective agents	2nd World Congress on Targeting Mitochondria (Berlim, Germany)
2011	Antioxidant therapy: in search of the magic bullet	2nd World Congress on Targeting Mitochondria (Berlim, Germany)
2010/05	Chromones: a valid scaffold for the development of potent and selective MAO-B inhibitors	III European Workshop in Drug Synthesis (Siena, Italy)
2010	From nature to drug discovery: the chromone scaffold as a ‘privileged structure’ for the development of novel A3 receptor ligands	III EWDSy- Third European Workshop in Drug Synthesis (Siena, Italy)
2009	Searching for novel monoamine oxidase inhibitors based on chromone scaffold	XXVIII Meeting of Clinical Pharmacology and IX Meeting of Toxicology (Porto, Portugal)
2009	Adenosine receptor binding and neurotoxicity of novel chromone based ligands	XL Meeting of Portuguese Society of Pharmacology, XXVIII Meeting of Clinical Pharmacology and IX Meeting of Toxicology (Porto, Portugal)
2008/04	Metabolic Toxicology: from Synthesis to (Bio)analysis	International Courses on Toxicology, Cell and Molecular Toxicology Research Area, Centre for Neurosciences and Cell Biology (Coimbra, Portugal)
2007/12	Opening the Pandora box: The Syntab Contribution to the knowledge on the Toxic Effects of Drugs of Abuse and Their Metabolites	XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de Toxicologia (Coimbra, Portugal)
2006/10	Finding the Toxicophore: a Challenging Target in Medicinal Chemistry	Medicinal Chemistry in the 21st Century (Lisboa, Portugal)
2005/10	Phenolic Derivatives: A Study on the Relationship between Structure, Activity and Physicochemical Parameters	Anti-Inflammatory Drugs (Paris, France)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/10 - Current	Descoberta e desenvolvimento de novos antibióticos tendo como base a estratégia do Cavalo de Troia Supervisor	Mestrado em Química (Master) Faculdade de Ciencias Universidade do Porto, Portugal
2022/02 - 2022/07	Descoberta e desenvolvimento de novos antibacterianos contra microrganismos multirresistentes Co-supervisor	Química Universidade do Porto Faculdade de Ciências, Portugal
2021/02 - 2021/07	síntese de novos antimicrobianos baseados em produtos naturais Co-supervisor	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2020/01/03 - 2020/07	Síntese de novos antimicrobianos baseados em produtos naturais Co-supervisor	Quimica (Degree)
2020/01 - 2020/06	Desenvolvimento de novos antibióticos baseados em modelos naturais Supervisor	Projecto extracurricular (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2020/01 - 2020/06	Desenvolvimento de novos antibióticos baseados em modelos naturais Supervisor	Projecto extracurricular (Degree)
2019/01 - 2019/09	Desenvolvimento de novos agentes antimicrobianos baseados em modelos naturais Co-supervisor	Quimica (Degree)
2017 - 2019	Design and synthesis of chromone like derivatives as multitarget ligands: for neurodegeneratives diseases Co-supervisor	Doutoramento (PhD) University “Magna Græcia, Italy
2016 - 2016	Evaluation of antioxidant activity of natural extracts Co-supervisor	Doutoramento (PhD) Università degli Studi di Cagliari, Italy
2014 - 2014	Synthesis, Purification, characterization of Hydroxytirosol, Adenosine and lipoic acid derivatives and evaluation of their antioxidant profile Co-supervisor	Doutoramento (PhD) Università degli Studi di Milano, Italy

Event organisation

	Event name Type of event (Role)	Institution / Organization
2017/10/14 - Current	Member of the organizing committee of the CIQUP’s workshop meeting (2017/10/17) Meeting (Member of the Organising Committee)	Universidade do Porto Centro de Investigação em Química, Portugal
2023/06/26 - 2023/07/12	Member of the organizing committee of the Course Erasmus+ Blended Intensive Programme: Drug Discovery 2030: A Roadmap for a New Decade (https://drugdiscovery2030.pt/) (2023/06/26 - 2023/07/12) Other (Member of the Organising Committee)
2018/07/12 - 2018/07/14	Member of the organizing committee VIII Meeting of the Paul Ehrlich EuroPhD Network (2018/07/12 - 2018/07/14) Congress (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal
2017/09/22 - 2017/09/24	Member of the organizing committee of the EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint annual meeting :A bridge between EpiChemBio and MuTaLig COST Actions (2017/09/22) Congress (Member of the Organising Committee)	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2016/06/29 - 2016/07/01	Member of the Local Organizing Committee of the 10th World Congress on Polyphenols Applications (2016/06/29) Congress (Member of the Organising Committee)	Instituto Politécnico do Porto, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/09/26	Desenvolvimento de novos agentes antibacterianos para combater as infeções hospitalares (Thesis) Main arguer	Catarina Pereira Alves (Master) Universidade de Coimbra Departamento de Química, Portugal
2023/06/14	Surfactants derived from proline and proline mimetics for application in transdermal drug delivery systems (Thesis) Main arguer	Ana Luísa Sousa Rocha (Other) Universidade do Porto Faculdade de Ciências, Portugal
2022/11/10	Microencapsulação do isotiocianato de benzilo com beta-ciclodextrinas (Thesis) Main arguer	Taynara Braga De Araújo (Master) Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2022/07/22	Biofilm disinfection with choline-based eutectic solvents (Thesis) Main arguer	Eva Carolina Freitas Correia (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2022/06/07	Lipid Homeostasis in Microglia During Exposure to Saturated Fat (Thesis) Main arguer	José Tomás Garrido Santos (Other) Faculdade de Ciencias Universidade do Porto, Portugal
2022/02/11	Efeito de Chalconas em Células da Granulosa (Thesis) Arguer	Ruben Lourenço Seixas (Other) Universidade do Porto Faculdade de Farmácia, Portugal
2019/07/18	Repurposing non-antibiotic drugs for antimicrobial purposes (Thesis) Main arguer	Cláudia Cristina Moreira Leão (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2019/07/10	Desenvolvimento de novos antioxidantes para o tratamento da doença de Alzheimer (Thesis) Main arguer	Cláudia Sofia Ferreira Pinto (Other) Universidade do Porto Faculdade de Ciências, Portugal
2018/07/07	The use of phytochemicals with EDTA as catheter lock solutions (Thesis) Main arguer	João Pedro Rocha Vale (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2018/04/26	Single and multi-target agents for neurodegenerative diseases based on the chromone scaffold” (Thesis) Arguer	Joana Alexandra Costa Reis (PhD) Faculdade de Ciencias Universidade do Porto, Portugal
2017/07/13	Síntese de derivados de piperazine com atividade inibitória da acetilcolinesterase como possível tratamento da Doenças de Alzheimer (Thesis) Main arguer	Tânia Catarina Pinto Moura (Other) Universidade do Porto Faculdade de Ciências, Portugal
2017/07/07	Análisis y predicciones teóricas en medicamentos y alimentos (Thesis) Main arguer	Estela Guardado Yordi (PhD) Universidade de Santiago de Compostela Departamento de Farmacoloxía Farmacia e Tecnoloxía Farmacéutica, Spain
2016/07/26	Desenvolvimento de novos antioxidantes tendo como base modelos naturais (Thesis) Main arguer	Mariana Fontoura da Fonseca Tavares Nogueira (Other) Universidade do Porto Faculdade de Ciências, Portugal

Association member

	Society Organization name	Role
2016/04/18 - 2020/04/17	COST Action AGA-CA15135-1(MuTaLig)	MC substitute member

Committee member

	Activity description Role	Institution / Organization
2023/11/08 - Current	Membro da Comissão Coordenadora (órgão de gestão) do CIQUP, eleita como representante dos investigadores não docentes Member	Centro de Investigação em Química da Universidade do Porto (CIQUP), Portugal
2022 - 2022/09	Guest editor Special Issue "In Honor of Prof. Dr. Fernanda Borges’s Contribution" Member
2019 - 2022	Membro da Comissão de Investigadores (eleita pela área de Química Orgânica/Medicinal) do Departamento de Química e Bioquímica 2019-2022 Member	Universidade do Porto Departamento de Química e Bioquímica, Portugal
2020 - 2021/01/31	Guest Editor of Special Issue "New Insights into Antimicrobial Drug Discovery" Member

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2014 - Current	Advances Methods in Structural Analysis	Quimica e bioquimica (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal
2014 - Current	Métodos Avançados de análise estrutural	(Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal

Journal scientific committee

	Journal title (ISSN)	Publisher
2018 - Current	Current Medicinal Chemistry	Bentham Science
2017 - Current	MedChemComm	RSC Publishing
2016 - Current	Biofouling	Taylor & Francis Online
2015 - Current	European Journal of Medicinal Chemistry	Elsevier

Distinctions

Award

2022	Prémio IACOBUS-papers
2020	best oral communication" Mapping the chromone-3-phenylcarboxamide pharmacophore: structure-activity-cytotoxicity and efflux transport studies" 4th WG meeting – MuTaLig COST Action – Final stutus of WG meeting, Turkey

Other distinction

2022	World’s Top 2% Scientists list (2021/2022) . Stanford University, United States
2017	Highly cited paper by web of science (received enough citations to place it in the top 1% of the academic field of Chemistry based on a highly cited threshold for the field and publication year)
2014	Paul Ehrlich MedChem Euro-PhD award
2013	III Escuela de Verano de la SEQT “Medicinal Chemistry in Drug Discovery: The Pharma Perspective
2013	Top-10 most cited articles for the article “Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors” J. Med. Chem., 54 (14), 5165-5173.
2012	ADDF Young Investigator Scholarship
2011	Prémio Provincial al trabajo
2006	Prémio da Spectro para melhor comunicação científica