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Carla A.M. Lopes is an Assistant Researcher (CEEC 5th Edition - FCT) and principal investigator at the Biomedicine Institute (iBiMED) at the University of Aveiro. Her scientific interests are directed at understanding the signaling component of centrosomes and cilia and harness its potential to improve prognostic and therapeutic tools in disease, particularly in cancer. Carla holds a degree in Biology by the University of Aveiro (2006) and a PhD in Biochemistry and Cell Biology by the University of Leicester, UK (2011). Her PhD work on centriolar satellites brought new ideas and concepts that extended our understanding of ciliopathies, and was distinguished with several awards, including a Best PhD prize, the 2011 JCS Best Paper Prize, and the 2008 Young UK Cell Biologist from the British Society for Cell Biology.  For her postdoc, Carla then joined a multidisciplinary team aiming to understand the role of centrosomes in human cancer. Working at Instituto Português de Oncologia de Lisboa (IPO), a leading hospital in cancer treatment and research, and at the multidisciplinary Instituto Gulbenkian de Ciência (IGC), Carla bridged fundamental and clinical research leading a study aimed at answering long-standing questions in her field. Her work established, for the first time, the timing and dynamics of centrosome abnormalities in human tumor initiation and progression (JCB 2018; cover; first and corresponding author). Illustrating the high quality and conceptual advance of this paper it has been highlighted in several Special Collections.  During her postdoctoral work Carla also contributed to numerous projects and published several articles (all in Q1 journals) and a book chapter (corresponding author). Carla has obtained several competitive grants (FCT, EMBO, Company of Biologists), including two research grants (FCT 2018, LPCC-NRS Terry Fox 2022) as Principal Investigator. She has supervised and trained several junior scientists at the BSc, MSc and PhD training levels and, from 2020 to 2023, she was also an Invited Professor at the Faculty of Sciences of the University of Lisbon. Carla has also always been engaged in outreach activities: organizing several scientific events, disseminating her research in the media and organizing and participating in several outreach activities aimed at promoting scientific culture in society (e.g. European Researcher's Night, IGC Open Days, Maratona da Saúde). In 2023 Carla joined the iBiMED as a principal investigator. Her research uses experimental models that mimic human physiology to uncover mechanisms of centrosome deregulation, with the goal of providing innovative strategies to improve human health.
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Identificação

Identificação pessoal

Nome completo
Carla Alexandra Mendes Lopes
Género
Feminino

Nomes de citação

  • Lopes, Carla AM
  • Lopes, CAM
  • Lopes, C.A.M.

Identificadores de autor

Ciência ID
B115-5246-DA68
ORCID iD
0000-0003-3182-8305
Google Scholar ID
hCUPXtQAAAAJ&hl

Endereços de correio eletrónico

  • calopes@ipolisboa.min-saude.pt (Profissional)
  • carlalopes@ua.pt (Profissional)
  • lopes.carla.am@gmail.com (Pessoal)

Moradas

  • iBiMED - Institute of Biomedicine, Campus Universitario de Santiago, Agra do Crasto - Edificio 30A, 3810-193, Aveiro, Aveiro, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2006/10 - 2011/07
Concluído
 PhD Biochemistry and Cell Biology (Doctor of Philosophy)
University of Leicester, Reino Unido
"Cellular studies on the Oral-facial-digital syndrome type 1 disease protein" (TESE/DISSERTAÇÃO)
 Prize for Best PhD 2010/11
2001/09 - 2006/06
Concluído
 Biology (Licenciatura)
Universidade de Aveiro, Portugal
"Centrosomal proteins in human inherited diseases" (TESE/DISSERTAÇÃO)
 16/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Aveiro, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
2019 - 2023 Pós-doutorado (Investigação) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2014 - 2019 Pós-doutorado (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2011 - 2013 Pós-doutorado (Investigação) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2006 - 2010 Investigador (Investigação) University of Leicester Department of Biochemistry, Reino Unido
University of Leicester School of Biological Sciences, Reino Unido
2005 - 2006 Estagiário de Investigação (Investigação) University of Leicester Department of Biochemistry, Reino Unido
University of Leicester Department of Cell Physiology and Pharmacology, Reino Unido
2004/09 - 2005/06 Estagiário de Investigação (Investigação) Universidade de Aveiro Departamento de Biologia, Portugal
Universidade de Aveiro Departamento de Biologia, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019 - 2023 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2004 - 2006 Guide/Monitor at Science Centre Fábrica - Centro de Ciência Viva, Portugal
Fábrica - Centro de Ciência Viva, Portugal
Produções

Publicações

Artigo em revista
  1. Di Nardo, Alessia; Lenoël, Isadora; Winden, Kellen D.; Rühmkorf, Alina; Modi, Meera E.; Barrett, Lee; Ercan-Herbst, Ebru; et al. "Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia". Cell Reports 31 12 (2020): 107780. http://dx.doi.org/10.1016/j.celrep.2020.107780.
    Acesso aberto • Publicado • 10.1016/j.celrep.2020.107780
  2. Lopes, Carla AM; Mesquita, Marta; Cunha, Ana Isabel; Cardoso, Joana; Carapeta, Sara; Laranjeira, Cátia; Pinto, António E.; et al. Autor correspondente: Lopes, Carla AM. "Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis". The Journal of Cell Biology 217 7 (2018): 2353-2363. http://dx.doi.org/10.1083/jcb.201711191.
    Publicado • 10.1083/jcb.201711191
  3. Pimenta-Marques, A; Lopes, Carla AM (B115-5246-DA68); Bento, Inês; Duarte, P.; Jana, SC; Bettencourt-Dias, Monica. "A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster". Science 353 6294 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84974602778&partnerID=MN8TOARS.
    Publicado • 10.1126/science.aaf4866
  4. Lopes, Carla AM (B115-5246-DA68); Jana, S.C.; Cunha-Ferreira, I.; Zitouni, S.; Bento, Inês; Duarte, P.; Gilberto, S.; et al. "PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space". Developmental Cell 35 2 (2015): 222-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945134296&partnerID=MN8TOARS.
    Publicado • 10.1016/j.devcel.2015.09.020
  5. Jerman, S.; Ward, H.H.; Lee, R.; Lopes, Carla AM; Fry, A.M.; MacDougall, M.; Wandinger-Ness, A.. "OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts". PLoS ONE 9 9 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84907457131&partnerID=MN8TOARS.
    Publicado • 10.1371/journal.pone.0106330
  6. Thauvin-Robinet, C.; Lee, J.S.; Lopez, E.; Herranz-Pérez, V.; Shida, T.; Franco, B.; Jego, L.; et al. "The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation". Nature Genetics 46 8 (2014): 905-911. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906101758&partnerID=MN8TOARS.
    Publicado • 10.1038/ng.3031
  7. Lopes, Carla AM; Prosser, S.L.; Romio, L.; Hirst, R.A.; O'Callaghan, C.; Woolf, A.S.; Fry, A.M.. "Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1". Journal of Cell Science 124 4 (2011): 600-612. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951829447&partnerID=MN8TOARS.
    Publicado • 10.1242/jcs.077156
  8. Hames, R.S.; Hames, R.; Prosser, S.L.; Euteneuer, U.; Lopes, Carla AM; Moore, W.; Woodland, H.R.; Fry, A.M.. "Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells". Experimental Cell Research 314 3 (2008): 574-589. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349047002&partnerID=MN8TOARS.
    Publicado • 10.1016/j.yexcr.2007.10.019
Capítulo de livro
  1. Peneda, Catarina; Lopes, Carla AM (B115-5246-DA68); Bettencourt-Dias, Mónica. Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Studying Centriole Duplication and Elongation in Human Cells". In Methods in Molecular Biology, 147-162. Springer US, 2020.
    Publicado • 10.1007/978-1-0716-0219-5_10
Poster em conferência
  1. Inês S. Gomes; Lopes, Carla AM. Autor correspondente: Lopes, Carla AM. "Impact of early centrosome deregulation in malignant transformation". Trabalho apresentado em ENJIO - Encontro Nacional de Jovens Investigadores em Oncologia, 2022.
  2. Inês S. Gomes; Lopes, Carla AM (B115-5246-DA68). Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Impact of early centrosome deregulation in malignant transformation". Trabalho apresentado em 5th ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 2022.
  3. Pereira, Miguel; Nunes, Leonor P.; Inês S. Gomes; Bettencourt-Dias, Monica; Lopes, Carla AM (B115-5246-DA68). Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Searching for biomarkers: impact of molecular changes in centrosome function and Barrett’s esophagus progression". Trabalho apresentado em 5th ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 2022.
  4. Lopes, Carla AM; Nunes, Leonor P.; Chaves, Paula; Bettencourt-Dias, Monica. Autor correspondente: Lopes, Carla AM. "Crosstalk of signaling hubs and chronic inflammation in human tumorigenesis". Trabalho apresentado em EACR-AACR-ASPIC Conference: Tumor Microenvironment, 2020.
  5. Lopes, Carla AM (B115-5246-DA68); Nunes, Leonor P.; Chaves, Paula; Bettencourt-Dias, Mónica. Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Crosstalk of signaling hubs and chronic inflammation in human tumorigenesis". Trabalho apresentado em Champalimaud Research Symposium 2019 on Tissue environment in health and disease, 2019.
  6. Nunes, Leonor P.; Bettencourt-Dias, Mónica; Chaves, Paula; Lopes, Carla AM (B115-5246-DA68). Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "The driving mechanisms of centrosome abnormalities in human tumorigenesis". Trabalho apresentado em Champalimaud Research Symposium 2019 on Tissue environment in health and disease, 2019.
  7. Lopes, Carla AM (B115-5246-DA68); Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Timing and regulation of centrosome amplification in human tumorigenesis". Trabalho apresentado em Symposium on Tumor Biology: from basic biology to disease, 2018.
  8. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Autor correspondente: Lopes, Carla AM. "Timing and regulation of centrosome amplification in human tumorigenesis". Trabalho apresentado em Champalimaud Research Symposium 2017 on Physiology: from development to disease, 2017.
  9. Lopes, Carla AM (B115-5246-DA68); Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Timing and regulation of centrosome amplification in human tumorigenesis". Trabalho apresentado em EMBO Conference on Centrosomes and SPBs, 2017.
  10. Lopes, Carla AM (B115-5246-DA68); Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Centrosome amplification in human tumorigenesis: where, when and how?". Trabalho apresentado em CRUK (Cancer Research UK) Symposium Oesophageal Cancer, 2017.
  11. Lopes, Carla AM (B115-5246-DA68); Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "Centrosome Amplification in human cancerigenesis: where, when and how?". Trabalho apresentado em EACR (European Association for Cancer Research) Conference Goodbye Flat Biology, 2016.
  12. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Autor correspondente: Lopes, Carla AM. "p53 loss leads to centrosome number amplification in tumor initiation". Trabalho apresentado em 3rd EMBO Conference on Centrosomes and SPBs, 2014.
  13. Lopes, Carla AM (B115-5246-DA68); Mesquita, Marta; Bettencourt-Dias, Mónica; Chaves, Paula. Autor correspondente: Lopes, Carla AM (B115-5246-DA68). "p53 loss leads to centrosome number amplification in tumor initiation". Trabalho apresentado em 1st ASPIC International Congress, 2014.
  14. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. "Unravelling novel mechanisms of Barrett’s esophagus progression: centrosome amplification precedes the onset of invasion". Trabalho apresentado em 25th European Congress of Pathology, 2013.
  15. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. "Centrosome profile in Barrett’s esophagus". Trabalho apresentado em 2nd EMBO Conference on Centrosomes and Spindle Pole Bodies, 2011.
  16. Lopes, Carla AM; Fry, A.M.. "The human ciliopathy disease gene OFD1 encodes a protein that colocalizes with PCM-1 on centriolar satellites". Trabalho apresentado em American Society for Cell Biology (ASCB) meeting, 2008.
  17. Lopes, Carla AM (B115-5246-DA68); Fry, A.M.. "The human ciliopathy disease gene OFD1 encodes a protein that colocalizes with PCM-1 on centriolar satellites". Trabalho apresentado em British Society for Cell Biology (BSCB) & BSDB meeting, 2008.
Tese / Dissertação
  1. Lopes, Carla AM. "Cellular studies on the Oral-facial-digital syndrome type 1 disease protein". Doutoramento, University of Leicester Department of Biochemistry, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529616.
Website
  1. Lopes, Carla AM. I designed the website for the conference I co-organized "3rd Cross-Institutional Meeting for Young Researchers". 2016. https://postdoccommittee.wixsite.com/retreat2016.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/02 Invited speaker: "O impacto da desregulação dos centrossomas em cancro" XI Jornadas de Investigação em Biologia - Núcleo de Estudantes de Biologia
Faculdade de Ciências, Universidade de Lisboa (Portugal)
2021/10/27 Invited speaker: "Centrosome abnormalities as biomarkers in human cancer" IBOMAN 2021 - Interplay between oncology, mathematics and numerics: focus on treatment studies
(Paris, França)
2019/11/29 Invited speaker: "Searching for new markers for risk stratification" Barrett’s esophagus 2019: from Biology to Managament
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal (Lisbon, Portugal)
2019/05/10 Invited speaker: "Investigação clínica e a sua translação para a prática" ("Clinical research and its translation into clinical practice") NursId - Semana de Investigação em Enfermagem
Escola Superior de Enfermagem do Porto (Porto, Portugal)
2019/05/03 Selected oral communication: "Crosstalk of signaling hubs and chronic inflammation in human tumorigenesis" Porto Cancer Meeting - The Cancer Ecosystem: From Research to Pathology and Treatment
i3S - Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2018/07/03 Invited speaker: "Deregulation of cellular structures associated with cancer" Ciência 2018
(Lisbon, Portugal)
2017/11/22 Invited speaker: "Timing is everything: Centrosomes & Cancer"
Barts Cancer Institute, UK
2017/10/19 Selected oral communication: "Timing is everything: Centrosomes & Cancer" International Joint Postdoc Retreat: Instituto Gulbenkian de Ciência, Babraham Institute, Max Planck Institute for Plant Breeding Research
Instituto Gulbenkian de Ciência, Babraham Institute, Max Planck Institute for Plant Breeding Research (Vimeiro, Portugal)
2017/06/30 Invited speaker: "Timing and regulation of centrosome amplification in Barrett's tumorigenesis" One day symposium with Patrick Tan: Knowns and Unknowns in Gastric Cancer and Other Tumours of the Digestive System
IPATIMUP (Porto, Portugal)
2016/04/28 Selected oral communication: "Centrosome amplification in human cancerigenesis: where, when and how?" 2nd ASPIC International Congress
IPATIMUP (Porto, Portugal)
2013/06/14 Selected oral communication: "New mechanisms in Barrett's esophagus progression: centrosome alterations precede invasion" National Congress of Gastroenterology
National Congress of Gastroenterology (Vilamoura, Portugal)
2011/11/30 Invited speaker: "Connecting the cell's antenna to human disease" Doctoral Inaugural Lecture
University of Leicester, UK (Leicester, Reino Unido)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/09 - Atual Supervisor of the Master's Project entitled: "Impact of centrosome deregulation in the inflammatory response and malignant transformation"
Orientador
 MSc in Molecular Biomedicine (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023/09 - Atual Supervisor of the BSc Research Project entitled: "Investigating molecular changes associated with centrosome deregulation in Barrett’s esophagus progression"
Orientador
 Biology (Licenciatura/Bacharelato)
Universidade de Aveiro Departamento de Biologia, Portugal
2022/09 - Atual Supervisor of the Master's Project entitled: "Impact of centrosome amplification in the malignant transformation of Barrett's Esophagus"
Orientador
 Master Programme in Biomedical Engineering (Mestrado)
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2021/10 - 2023/02 Supervisor of the Master's Project entitled: "Interplay between centrosome abnormalities and the microenvironment in the progression of Barrett's esophagus" (Student's final mark: 18/20)
Orientador
 Master Programme in Molecular Biology and Genetics (Mestrado)
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09 - 2023/01 Supervisor of the Master's Project entitled: "Impact of molecular changes in centrosome function and Barrett's esophagus progression" (Student's final mark: 18/20)
Orientador
 Master Programme in Molecular Biology and Genetics (Mestrado)
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09 - 2023 Internal supervisor of the Master's Project entitled: "Impact of anti-CTLA4 and anti-PD1 on the crosstalk between cancer and immune cells, underlying CAT-VTE"
Coorientador
 Master Programme in Human Biology and Environment (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09 - 2023 Internal supervisor of the Master's Project entitled: "Functional and clinical impact of ARL15 in cutaneous melanoma aggressiveness"
Coorientador
 Master Programme in Molecular Biology and Genetics (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2020/09 - 2022/02 Internal supervisor of the Master's Project entitled: "Establishment of a glioblastoma zebrafish xenograft model"
Coorientador
 Master Programme in Evolutionary and Developmental Biology (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Centro Champalimaud, Portugal
2020/09 - 2022/02 Internal supervisor of the Master's Project entitled: "Regulation of LDLR expression in breast cancer cells and its implication in tumour progression"
Coorientador
 Master Programme in Molecular Biology and Genetics (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2020/09 - 2022/02 Supervisor of the Master's Project entitled: "Impact of early centrosome deregulation in malignant transformation" (Student's final mark: 19/20)
Orientador
 Master Programme in Molecular Biology and Genetics (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2018/09 - 2019/11 Supervisor of the Master's Project entitled: "Molecular changes associated with the origin of centrosome amplification in human cancer" (Student's final mark 19/20)
Orientador
 Master Programme in Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Instituto Gulbenkian de Ciência, Portugal
2018/01 - 2018/06 Supervisor of the laboratorial work of PhD project (PhD program in Integrative Biology and Biomedicine) entitled: "Population dynamics of centrosome amplification"
Coorientador
Instituto Gulbenkian de Ciência, Portugal
2017/02 - 2017/02 Supervisor of a short scientific project entitled: "How is centriole length regulated?"
Orientador
Instituto Gulbenkian de Ciência, Portugal
2016/07 - 2016/08 Supervisor of a short scientific project entitled: "Origin of centrosome amplification in human cancerigenesis"
Orientador
Instituto Gulbenkian de Ciência, Portugal
2016/07 - 2016/08 Supervisor of a short scientific project entitled: "Modelling evolution of cells with varying centriole numbers in cancer"
Coorientador
Instituto Gulbenkian de Ciência, Portugal
2008/10 - 2010/06 Supervisor of the laboratorial work of PhD project entitled: "Regulation of the human Nek8/NPHP9 protein during cell cycle progression and ciliogenesis"
Coorientador
University of Leicester Department of Biochemistry, Reino Unido
2007/10 - 2008/06 Co-supervisor of a scientific internship project entitled: "Centrosomal proteins in human inherited disease – Oral-­facial-­digital syndrome type 1"
Coorientador
University of Leicester Department of Biochemistry, Reino Unido

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2016/01 - 2016/12 Main co-organizer of the scientific seminar series "20 minutes with..." - Postdoc & PhD students seminars (2016/01 - 2016/12)
Seminário (Coorganizador)
 Instituto Gulbenkian de Ciência, Portugal
2016/01 - 2016/10 Member of the organising committee of the "3rd Cross-Institutional Meeting of Young Investigators" - conference for young researchers from four major research institutes in the Lisbon area to foster interactions and a starting point for strategic cooperation. Besides funding from the institutes involved, secured 3.300€ from sponsors. (https://postdoccommittee.wixsite.com/retreat2016/organizers) (2016/10/19 - 2016/10/21)
Conferência (Membro da Comissão Organizadora)
 Instituto Gulbenkian de Ciência, Portugal

Centro Champalimaud, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016/01 - 2016/10 Member of the organising committee of the 2016 IGC Open Day "Ciência em Zoom"(https://diaaberto16.wordpress.com/organizacao/) (2016/10/01 - 2016/10/01)
Exposição (Membro da Comissão Organizadora)
 Instituto Gulbenkian de Ciência, Portugal
2016 - 2016 Main co-organizer of a workshop aimed to increase researchers' understanding of how peer-review works, and what makes a good review - "eLife Peer-Reviewing Workshop". Secured full sponsorship from eLife. (2016/07/01 - 2016/07/01)
Oficina (workshop) (Coorganizador)
 Instituto Gulbenkian de Ciência, Portugal
2002 - 2006 Co-organizer of "Biologia na Noite" - Conference Series aimed to promote scientific knowledge and debate to the wider audience. (2002 - 2006)
Conferência (Membro da Comissão Organizadora)
 Universidade de Aveiro, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020/04 - 2020/05 Covid-19 Task Force - volunteer in testing Covid-19 Task Force
Instituto Gulbenkian de Ciência, Portugal
2019/03 - 2019/05 Outreach: Invited to talk about cancer research to the general public at different institutions from Santa Casa da Misericórdia - organized by Maratona da Saúde "Conhecer o Cancro" “Conhecer o Cancro”
Maratona da Saúde, Portugal
2018/10/15 - 2018/10/15 Outreach: Invited speaker in "À Conversa com Cientistas" - an initiative, part of the IGC 2018 Open Day, that fosters dialogue between scientists and the general public. Topic of the session: "Cancer and ageing"
Mesa-redonda
 2018 IGC Open Day
Instituto Gulbenkian de Ciência, Portugal
2018 - 2018 Outreach: "Job Shadowing - Scientist for a day" - I hosted highschool students in the lab to show and discuss what is it like to be a scientist
Exposição
 Job Shadowing - Scientist for a day
Instituto Gulbenkian de Ciência, Portugal
2017/09/29 - 2017/09/29 Outreach: Developed and showed an activity to explore the biology of cancer for Noite Europeia dos Investigadores - a science communication event taking place all over Europe.
Exposição
 Noite Europeia dos Investigadores - Pavilhão do Conhecimento
Ciência Viva, Portugal
2008 - 2008 Outreach: Festival of Postgraduate Research - Participated in communicating my research to a wider audience.
Exposição
 Festival of Postgraduate Research 2008
University of Leicester, Reino Unido
2004 - 2006 Outreach: Founding member of the Science Centre communicating science to the wider audience ranging all ages
Exposição
 Ciência Viva
Fábrica - Centro de Ciência Viva, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/02 Master's Project entitled: "Interplay between centrosome abnormalities and the microenvironment in the progression of Barrett’s esophagus"
Orientador
 Inês Afonso dos Santos (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/01 Master's Project entitled: "Impact of molecular changes in centrosome function and Barrett¿s Esophagus progression"
Orientador
 Miguel Amador Pereira (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/02 Master's Project entitled: "Impact of early centrosome deregulation in malignant transformation"
Orientador
 Inês Simões Gomes (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/11 Master's Project entitled: "Molecular changes associated with the origin of centrosome amplification in human cancer"
Orientador
 Leonor Nunes (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/07 Main examiner of the BSc Thesis entitled: "Molecular aspects underlaying Social Behavior: Oxytocin modulation in neuronal social circuitry"
Arguente principal
 Pedro Castelhanito (Outro)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual Biochimica et Biophysica Acta - Reviews on Cancer (0304-419X) Elsevier
2015 - Atual Journal of Cell Science (0021-9533 ) The Company of Biologists

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2018 - 2020 Evaluator of research project calls for "Bolsas LPCC-NRS/Terry Fox" from the Liga Portuguesa Contra o Cancro
Avaliador
 Liga Portuguesa Contra o Cancro, Portugal Liga Portuguesa Contra o Cancro
2017 - 2017 Evaluator of research project calls for "Fundo de Apoio à Investigação do Instituto Português de Oncologia de Lisboa"
Avaliador
 Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE
2017 - 2017 Evaluator of research project calls for "Innovate Competition iMed Lisbon"
Avaliador
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Fundação AstraZeneca

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023 - 2023 Tutor in Biopathology Course Biopathology Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2020 - 2023 Lecturer and Coordinator of the Master's degree module: "Molecular and Cell Biology of Cancer" Master Degree in Molecular Biology and Genetics and Master Degree in Evolutionary and Developmental Biology (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Invited to give class to Medicine students on "Centrosomes in Cancer" within Biopathologic Seminar - Pathology course Medicine (Licenciatura) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021 - 2021 Invited to give class to Medicine students on "Centrosomes in Cancer" within Oncobiology course Medicine (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2019 Invited to give class on "Cell Cycle and Cancer" in the Master's degree module "Molecular and Cell Biology of Cancer" Master Degree in Molecular Biology and Genetics and Master Degree in Evolutionary and Developmental Biology (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2008 Tutor in practical demonstrations in "Cancer Cell" and "Molecular Biology" modules for undergraduate students (Bachelor) University of Leicester Department of Biochemistry, Reino Unido

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2018 Interviewed by the national newspaper Público featuring my research article published in JCB 2018 - "Células dão um sinal de alarme antes do cancro do esófago" Público
2012 Interviewed by the national newspaper Diário de Notícias for a special edition featuring young people viewed with potential to succeed in their fields "Mentes Brilhantes na Casa dos 20" Diário de Nótícias
2012 Interviewed by University of Aveiro Online featuring my award for Best Paper 2011 on JCS Aveiro Online
2012 Interviewed by University of Leicester Online featuring my award for Best Paper 2011 on JCS University of Leicester Online
2012 Interviewed by Domingo Magazine from the national newspaper Correio da Manhã featuring my award for Best Paper 2011 on JCS Domingo Magazine in Correio da Manhã
2012 Interviewed by the online news website Ciência Hoje featuring my award for Best Paper 2011 on JCS Ciência Hoje

Entrevista / Programa (rádio / tv)

Programa Tema
2018/05/26 - Atual Interviewed for the program "Os Dias do Futuro" on the national radio Antena 1, regarding the findings published in Lopes et al (2018) JCB Os centrossomas e o cancro de esófago
2019 - 2019 Interviewed for the national television RTP special telethon to raise funds for cancer research by Maratona da Saúde "Conhecer o Cancro"
2015 - 2015 Launched a video to explain to a wider audience the results obtained in one of my projects (Lopes et al, 2015, Dev Cell), in English and Portuguese; also participated in a follow-up "Q&A with the scientists" on social media. "How do cells control the localization of new internal structures?"
2011 - 2011 Radio message for the program "Mais Ciência, Melhor Saúde" on national radio TSF regarding the project studying centrosome abnormalities in Barrett's esophagus cancerigenesis Os centrossomas e o cancro de esófago

Membro de associação

Nome da associação Tipo de participação
2016 - Atual Associação Portuguesa para a Investigação em Cancro (ASPIC) / European Association for Cancer Research (EACR) Member
2006 - 2010 British Society for Cell Biology Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019 - 2020 Part of the working group implemmenting the 40 principles of the ‘European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers’ for HR certification within EU called Human Resources Strategy for Researchers – HRS4R
Membro
 Instituto Gulbenkian de Ciência, Portugal
2018 - 2018 IGC Postdoctoral Delegate - Representative of Postdoctoral Fellows; conduit between the postdoc body, administration and Scientific Advisory Board
Membro
 Instituto Gulbenkian de Ciência, Portugal
2015/09 - 2016/12 IGC Postdoc Committee - Representative of Postdoctoral Fellows & Organization of scientific events
Membro
 Instituto Gulbenkian de Ciência, Portugal
Distinções

Prémio

2011 Best PhD Prize
University of Leicester, Reino Unido
2011 Prize for Best Paper
The Company of Biologists - Journal of Cell Science, Reino Unido
2008 Young UK Cell Biologist
British Society for Cell Biology, Reino Unido
2008 Adamson Jones Prize for Best Presentation
University of Leicester, Reino Unido

Outra distinção

2022 Awarded with funding as Principal Investigator with a grant from Liga Portuguesa Contra o Cancro-NRS - Bolsa Terry Fox (15K).
Liga Portuguesa Contra o Cancro, Portugal
2022 Assistant Researcher (CEECIND 5th Edition, 2022) (Competitive FCT Call)
Fundação para a Ciência e a Tecnologia, Portugal
2022 Best Teacher - 2nd semester in 2nd Cycle of Studies of the Master Program in Molecular Biology and Genetics (Núcleo de Estudantes de Biologia, Fac. Ciências, Univ. Lisboa)
2019 2018 JCB Special Collection on Centrosomes and Cilia featuring scientific publication Lopes et al. 2018 JCB
Journal of Cell Biology, Estados Unidos
2019 2019 JCB Special Collection on Cancer Cell Biology featuring scientific publication Lopes et al. 2018 JCB
Journal of Cell Biology, Estados Unidos
2018 Cover of the scientific journal Journal of Cell Biology issue featuring Lopes et al. (2018) JCB
Journal of Cell Biology, Estados Unidos
2018 JCB Special Collection on Cancer Plasticity and Heterogeneity featuring scientific publication Lopes et al. 2018 JCB
Journal of Cell Biology, Estados Unidos
2018 Awarded with funding as Principal Investigator with a grant from FCT (PTDC/MED-ONC/31565/2017 - 240K)
Fundação para a Ciência e a Tecnologia, Portugal
2017 EMBO Short-term Fellowship
European Molecular Biology Organization, Alemanha
2017 The Company of Biologists/JCS Travel Fellowship
The Company of Biologists, Reino Unido
2017 Individual Postdoctoral Fellowship (Competitive FCT Call)
Fundação para a Ciência e a Tecnologia, Portugal
2008 Travel Award to attend the 1st EMBO Conference on Centrosomes and Spindle Pole Bodies in Heidelberg, Germany
British Society for Cell Biology, Reino Unido
2008 Travel Award to attend the American Society for Cell Biology conference in San Francisco, USA
British Society for Cell Biology, Reino Unido
2008 Travel Award to attend the BSCB&BSDB joint meeting in Warwick, UK
British Society for Cell Biology, Reino Unido
2006 Individual PhD Fellowship (Competitive FCT Call)
Fundação para a Ciência e a Tecnologia, Portugal
2005 Leonardo da Vinci Fellowship - EU Commission Mobility Program
European Comission, Bélgica