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Marie Ouarné is a junior researcher focusing her research on vascular development and diseases. Marie Ouarné graduated from one of the top-level French Universities in biotechnology engineering, the ENSTBB in 2014. Then, she successfully completed her PhD in Cell Biology at the Université Grenoble Alpes and the CEA/IRIG in 2017. Since 2018, she is working in Claudio Franco's lab at the Instituto de Medicina Molecular as a junior postdoctoral researcher and is part of the ATTRACT Leducq transatlantic network. During her research carreer, Marie Ouarné successfully won highly competitive grants. In 2014, she obtained an international Irtelis funding from the CEA (~20/400) to finance her PhD during which she participated to successfull grant writings at the Ligue Contre le Cancer and the Fondation ARC pour la recherche sur le cancer. More recently, in 2019, she obtained a Marie Curie Individual Fellowship to finance her postdoctoral work.
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Identificação

Identificação pessoal

Nome completo
Marie Ouarné

Nomes de citação

  • Ouarné, Marie

Identificadores de autor

Ciência ID
5812-BBB8-51A4
ORCID iD
0000-0003-4724-4363

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia
  • Ciências Naturais - Ciências Biológicas - Biologia do Desenvolvimento
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2017/11/16
Concluído
 Ph.D. in Cell Biology (Doctor of Philosophy)
Université Grenoble Alpes École Doctorale Chimie et Sciences du Vivant, França

Commissariat à l'Énergie Atomoique et aux Énergies Alternatives - Direction de la Recherche Fondamentale -Institut de recherche interdisciplinaire de Grenoble, França
"ALK1: a new pathway in physiological and tumoral vascular development" (TESE/DISSERTAÇÃO)
2014/06
Concluído
 Master’s degree in Biotechnology engineering (Diplôme d´études supérieures)
Especialização em Biotechnology
ENSTBB, França
"Synthesis and screening of bicyclic peptide libraries as potential Avastin inhibitors" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/05 - Atual Pós-doutorado (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2014/10 - 2017/12 Investigador (Investigação) Commissariat à l'Énergie Atomique et aux Énergies Alternatives - Centre de Grenoble, França
Commissariat à l'Énergie Atomique et aux Énergies Alternatives - Centre de Grenoble, França
(...)
2013/08 - 2014/02 Estagiário de Investigação (Investigação) Pepscan Therapeutics, Países Baixos
ENSTBB, França
(...)
2012/06 - 2012/08 Estagiário de Investigação (Investigação) Institut des Maladies Métaboliques et Cardiovasculaires, França
ENSTBB, França
(...)
Projetos

Bolsa

Designação Financiadores
2022/04 - 2023/09 Estudo da dinâmica do pericito durante o desenvolvimento vascular
Provided by PTCRIS: EXPL/MED-ANM/1616/2021
 Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2019/10/01 - Atual Adaptive and maladaptive endothelial cell dynamics during blood flow-driven vascular patterning
842498
Instituto de Medicina Molecular, Portugal
 European Commission
Em curso
Produções

Publicações

Artigo em revista
  1. Sara Silva Pereira; Mariana De Niz; Karine Serre; Marie Ouarné; Joana E Coelho; Cláudio A Franco; Luisa M Figueiredo. "Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis". eLife (2022): https://doi.org/10.7554/eLife.77440.
    10.7554/eLife.77440
  2. "Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence". Cell Reports 36 12 (2021): 109741-109741. http://dx.doi.org/10.1016/j.celrep.2021.109741.
    10.1016/j.celrep.2021.109741
  3. "From remodeling to quiescence: The transformation of the vascular network". Cells & Development (2021): 203735-203735. http://dx.doi.org/10.1016/j.cdev.2021.203735.
    10.1016/j.cdev.2021.203735
  4. "Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10". Cardiovascular Research (2021): http://dx.doi.org/10.1093/cvr/cvab187.
    10.1093/cvr/cvab187
  5. "Methods to quantify endothelial cell front-rear polarity in vivo and in vitro". Current Opinion in Hematology 28 3 (2021): 208-213. http://dx.doi.org/10.1097/moh.0000000000000643.
    10.1097/moh.0000000000000643
  6. Prahst, Claudia; Ashrafzadeh, Parham; Mead, Thomas; Figueiredo, Ana; Chang, Karen; Richardson, Douglas; Venkaraman, Lakshmi; et al. "Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy". eLife 9 (2020): http://dx.doi.org/10.7554/elife.49779.
    10.7554/elife.49779
  7. Desroches-Castan, Agnès; Tillet, Emmanuelle; Ricard, Nicolas; Ouarné, Marie; Mallet, Christine; Feige, Jean-Jacques; Bailly, Sabine. "Differential Consequences of Bmp9 Deletion on Sinusoidal Endothelial Cell Differentiation and Liver Fibrosis in 129/Ola and C57BL/6 Mice". Cells 8 9 (2019): 1079. http://dx.doi.org/10.3390/cells8091079.
    10.3390/cells8091079
  8. Desroches-Castan, Agnès; Tillet, Emmanuelle; Ricard, Nicolas; Ouarné, Marie; Mallet, Christine; Belmudes, Lucid; Couté, Yohann; et al. "Bone Morphogenetic Protein 9 Is a Paracrine Factor Controlling Liver Sinusoidal Endothelial Cell Fenestration and Protecting Against Hepatic Fibrosis". Hepatology 70 4 (2019): 1392-1408. http://dx.doi.org/10.1002/hep.30655.
    10.1002/hep.30655
  9. Barbacena, Pedro; Ouarné, Marie; Haigh, Jody J.; Vasconcelos, Francisca F.; Pezzarossa, Anna; Franco, Claudio A.. "GNrep mouse: A reporter mouse for front–rear cell polarity". genesis (2019): e23299. http://dx.doi.org/10.1002/dvg.23299.
    10.1002/dvg.23299
  10. Ouarné, Marie; Bouvard, Claire; Boneva, Gabriela; Mallet, Christine; Ribeiro, Johnny; Desroches-Castan, Agnès; Soleilhac, Emmanuelle; et al. "BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer". Journal of Experimental & Clinical Cancer Research 37 1 (2018): http://dx.doi.org/10.1186/s13046-018-0885-1.
    10.1186/s13046-018-0885-1
  11. Tillet, Emmanuelle; Ouarné, Marie; Desroches-Castan, Agnès; Mallet, Christine; Subileau, Mariela; Didier, Robin; Lioutsko, Anna; et al. "A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma". Journal of Biological Chemistry 293 28 (2018): 10963-10974. http://dx.doi.org/10.1074/jbc.ra118.002968.
    10.1074/jbc.ra118.002968
  12. Levet, Sandrine+; Ouarné, Marie+; Ciais, Delphine; Coutton, Charles; Subileau, Mariela; Mallet, Christine; Ricard, Nicolas; et al. "BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus". Proceedings of the National Academy of Sciences 112 25 (2015): E3207-E3215. http://dx.doi.org/10.1073/pnas.1508386112.
    10.1073/pnas.1508386112
Poster em conferência
  1. Ouarné, Marie. "BMP9 and BMP10 as anti-angiogenic targets in preclinical mammary cancer?". Trabalho apresentado em French Society of Angiogenesis meeting, 2017.
  2. Ouarné, Marie. "BMP9 in murine clinical breast cancer". Trabalho apresentado em BMP Signalling in Cancer meeting, 2016.
  3. Ouarné, Marie. "BMP9 and BMP10 via endMT induction are necessary for proper closure of the ductus arteriosus". Trabalho apresentado em French Society of Angiogenesis meeting, 2015.
Tese / Dissertação
  1. Ouarné, Marie. "ALK1: a new pathway in physiological and tumoral vascular development". Doutoramento, Université Grenoble Alpes, 2017. https://tel.archives-ouvertes.fr/tel-01706596.

Outros

Outra produção
  1. Immunopathology and parasite sequestration cause severe cerebral trypanosomiasis in animals. 2021. Sara Silva Pereira; Mariana De Niz; Karine Serre; Marie Ouarné; Claudio A Franco; Luisa M Figueiredo. https://doi.org/10.21203/rs.3.rs-1050698/v1.
    10.21203/rs.3.rs-1050698/v1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2017 Roles of BMP9 and BMP10 in murine models of mammary cancer TGF-beta meeting
(Uppsala, Suécia)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2016/10 - 2016/12 Cell Biology - Practice course Licence 3 (Licence) Université Grenoble Alpes, França
2015/09 - 2015/10 Cell Biology - Practice course Licence 1 (Licence) Université Grenoble Alpes, França

Membro de associação

Nome da associação Tipo de participação
2019/02 - Atual Postdoctoral association Member of the Postdoctoral association, responsible for meeting and workshop organization including the Lisbon Area PostDoc meeting 2020.
2016 - 2017 Pint of Science France City coordinator (Grenoble)
2014 - 2016 Pint of Science France Event manager (Grenoble)

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/10 - Atual IMM Green Team. Group of IMM members to work on Sustainable Science. Our objective is to find the best ways to recycle more, to reduce plastic and to promote energy saving in our daily routines, without compromising the amazing Science performed at IMM.
Membro
 Instituto de Medicina Molecular, Portugal
2014 - 2017 Young scientists animation comitee of the Biosciences and Biotechnology Institute of Grenoble (currently Interdisciplinary Research Institute of Grenoble). Organization of bi-mensual seminars for young scientists.
Membro
 Interdisciplinary Research Institute of Grenoble, França

Tutoria

Tópico Nome do aluno
2017/09 - 2017/12 Roles of BMP9 and BMP10 in murine mammary cancer Gabriela Boneva
2017/05 - 2017/06 Roles of BMP9 and BMP10 in murine mammary cancer Sonia Vection
2016/05 - 2016/06 Localization of BMP10 expression in mice Quentin Roux
Distinções

Prémio

2017 Best poster award
French Society of Angiogenesis, França