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Marie Ouarné is a junior researcher focusing her research on vascular development and diseases. Marie Ouarné graduated from one of the top-level French Universities in biotechnology engineering, the ENSTBB in 2014. Then, she successfully completed her PhD in Cell Biology at the Université Grenoble Alpes and the CEA/IRIG in 2017. Since 2018, she is working in Claudio Franco's lab at the Instituto de Medicina Molecular as a junior postdoctoral researcher and is part of the ATTRACT Leducq transatlantic network. During her research carreer, Marie Ouarné successfully won highly competitive grants. In 2014, she obtained an international Irtelis funding from the CEA (~20/400) to finance her PhD during which she participated to successfull grant writings at the Ligue Contre le Cancer and the Fondation ARC pour la recherche sur le cancer. More recently, in 2019, she obtained a Marie Curie Individual Fellowship to finance her postdoctoral work.
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Identification

Personal identification

Full name
Marie Ouarné

Citation names

  • Ouarné, Marie

Author identifiers

Ciência ID
5812-BBB8-51A4
ORCID iD
0000-0003-4724-4363

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Developmental Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2017/11/16
Concluded
 Ph.D. in Cell Biology (Doctor of Philosophy)
Université Grenoble Alpes École Doctorale Chimie et Sciences du Vivant, France

Commissariat à l'Énergie Atomoique et aux Énergies Alternatives - Direction de la Recherche Fondamentale -Institut de recherche interdisciplinaire de Grenoble, France
"ALK1: a new pathway in physiological and tumoral vascular development" (THESIS/DISSERTATION)
2014/06
Concluded
 Master’s degree in Biotechnology engineering (Diplôme d´études supérieures)
Major in Biotechnology
ENSTBB, France
"Synthesis and screening of bicyclic peptide libraries as potential Avastin inhibitors" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2018/05 - Current Postdoc (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2014/10 - 2017/12 Researcher (Research) Commissariat à l'Énergie Atomique et aux Énergies Alternatives - Centre de Grenoble, France
Commissariat à l'Énergie Atomique et aux Énergies Alternatives - Centre de Grenoble, France
(...)
2013/08 - 2014/02 Research Trainee (Research) Pepscan Therapeutics, Netherlands
ENSTBB, France
(...)
2012/06 - 2012/08 Research Trainee (Research) Institut des Maladies Métaboliques et Cardiovasculaires, France
ENSTBB, France
(...)
Projects

Grant

Designation Funders
2022/04 - 2023/09 Estudo da dinâmica do pericito durante o desenvolvimento vascular
Provided by PTCRIS: EXPL/MED-ANM/1616/2021
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2019/10/01 - Current Adaptive and maladaptive endothelial cell dynamics during blood flow-driven vascular patterning
842498
Instituto de Medicina Molecular, Portugal
 European Commission
Ongoing
Outputs

Publications

Conference poster
  1. Ouarné, Marie. "BMP9 and BMP10 as anti-angiogenic targets in preclinical mammary cancer?". Paper presented in French Society of Angiogenesis meeting, 2017.
  2. Ouarné, Marie. "BMP9 in murine clinical breast cancer". Paper presented in BMP Signalling in Cancer meeting, 2016.
  3. Ouarné, Marie. "BMP9 and BMP10 via endMT induction are necessary for proper closure of the ductus arteriosus". Paper presented in French Society of Angiogenesis meeting, 2015.
Journal article
  1. Sara Silva Pereira; Mariana De Niz; Karine Serre; Marie Ouarné; Joana E Coelho; Cláudio A Franco; Luisa M Figueiredo. "Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis". eLife (2022): https://doi.org/10.7554/eLife.77440.
    10.7554/eLife.77440
  2. "Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence". Cell Reports 36 12 (2021): 109741-109741. http://dx.doi.org/10.1016/j.celrep.2021.109741.
    10.1016/j.celrep.2021.109741
  3. "From remodeling to quiescence: The transformation of the vascular network". Cells & Development (2021): 203735-203735. http://dx.doi.org/10.1016/j.cdev.2021.203735.
    10.1016/j.cdev.2021.203735
  4. "Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10". Cardiovascular Research (2021): http://dx.doi.org/10.1093/cvr/cvab187.
    10.1093/cvr/cvab187
  5. "Methods to quantify endothelial cell front-rear polarity in vivo and in vitro". Current Opinion in Hematology 28 3 (2021): 208-213. http://dx.doi.org/10.1097/moh.0000000000000643.
    10.1097/moh.0000000000000643
  6. Prahst, Claudia; Ashrafzadeh, Parham; Mead, Thomas; Figueiredo, Ana; Chang, Karen; Richardson, Douglas; Venkaraman, Lakshmi; et al. "Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy". eLife 9 (2020): http://dx.doi.org/10.7554/elife.49779.
    10.7554/elife.49779
  7. Desroches-Castan, Agnès; Tillet, Emmanuelle; Ricard, Nicolas; Ouarné, Marie; Mallet, Christine; Feige, Jean-Jacques; Bailly, Sabine. "Differential Consequences of Bmp9 Deletion on Sinusoidal Endothelial Cell Differentiation and Liver Fibrosis in 129/Ola and C57BL/6 Mice". Cells 8 9 (2019): 1079. http://dx.doi.org/10.3390/cells8091079.
    10.3390/cells8091079
  8. Desroches-Castan, Agnès; Tillet, Emmanuelle; Ricard, Nicolas; Ouarné, Marie; Mallet, Christine; Belmudes, Lucid; Couté, Yohann; et al. "Bone Morphogenetic Protein 9 Is a Paracrine Factor Controlling Liver Sinusoidal Endothelial Cell Fenestration and Protecting Against Hepatic Fibrosis". Hepatology 70 4 (2019): 1392-1408. http://dx.doi.org/10.1002/hep.30655.
    10.1002/hep.30655
  9. Barbacena, Pedro; Ouarné, Marie; Haigh, Jody J.; Vasconcelos, Francisca F.; Pezzarossa, Anna; Franco, Claudio A.. "GNrep mouse: A reporter mouse for front–rear cell polarity". genesis (2019): e23299. http://dx.doi.org/10.1002/dvg.23299.
    10.1002/dvg.23299
  10. Ouarné, Marie; Bouvard, Claire; Boneva, Gabriela; Mallet, Christine; Ribeiro, Johnny; Desroches-Castan, Agnès; Soleilhac, Emmanuelle; et al. "BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer". Journal of Experimental & Clinical Cancer Research 37 1 (2018): http://dx.doi.org/10.1186/s13046-018-0885-1.
    10.1186/s13046-018-0885-1
  11. Tillet, Emmanuelle; Ouarné, Marie; Desroches-Castan, Agnès; Mallet, Christine; Subileau, Mariela; Didier, Robin; Lioutsko, Anna; et al. "A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma". Journal of Biological Chemistry 293 28 (2018): 10963-10974. http://dx.doi.org/10.1074/jbc.ra118.002968.
    10.1074/jbc.ra118.002968
  12. Levet, Sandrine+; Ouarné, Marie+; Ciais, Delphine; Coutton, Charles; Subileau, Mariela; Mallet, Christine; Ricard, Nicolas; et al. "BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus". Proceedings of the National Academy of Sciences 112 25 (2015): E3207-E3215. http://dx.doi.org/10.1073/pnas.1508386112.
    10.1073/pnas.1508386112
Thesis / Dissertation
  1. Ouarné, Marie. "ALK1: a new pathway in physiological and tumoral vascular development". PhD, Université Grenoble Alpes, 2017. https://tel.archives-ouvertes.fr/tel-01706596.

Other

Other output
  1. Immunopathology and parasite sequestration cause severe cerebral trypanosomiasis in animals. 2021. Sara Silva Pereira; Mariana De Niz; Karine Serre; Marie Ouarné; Claudio A Franco; Luisa M Figueiredo. https://doi.org/10.21203/rs.3.rs-1050698/v1.
    10.21203/rs.3.rs-1050698/v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017 Roles of BMP9 and BMP10 in murine models of mammary cancer TGF-beta meeting
(Uppsala, Sweden)

Association member

Society Organization name Role
2019/02 - Current Postdoctoral association Member of the Postdoctoral association, responsible for meeting and workshop organization including the Lisbon Area PostDoc meeting 2020.
2016 - 2017 Pint of Science France City coordinator (Grenoble)
2014 - 2016 Pint of Science France Event manager (Grenoble)

Committee member

Activity description
Role 		Institution / Organization
2019/10 - Current IMM Green Team. Group of IMM members to work on Sustainable Science. Our objective is to find the best ways to recycle more, to reduce plastic and to promote energy saving in our daily routines, without compromising the amazing Science performed at IMM.
Member
 Instituto de Medicina Molecular, Portugal
2014 - 2017 Young scientists animation comitee of the Biosciences and Biotechnology Institute of Grenoble (currently Interdisciplinary Research Institute of Grenoble). Organization of bi-mensual seminars for young scientists.
Member
 Interdisciplinary Research Institute of Grenoble, France

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016/10 - 2016/12 Cell Biology - Practice course Licence 3 (Licence) Université Grenoble Alpes, France
2015/09 - 2015/10 Cell Biology - Practice course Licence 1 (Licence) Université Grenoble Alpes, France

Mentoring / Tutoring

Topic Student name
2017/09 - 2017/12 Roles of BMP9 and BMP10 in murine mammary cancer Gabriela Boneva
2017/05 - 2017/06 Roles of BMP9 and BMP10 in murine mammary cancer Sonia Vection
2016/05 - 2016/06 Localization of BMP10 expression in mice Quentin Roux
Distinctions

Award

2017 Best poster award
French Society of Angiogenesis, France