???global.info.a_carregar???
Degree in Pharmaceutical Sciences from the Regional University of the Northwest of the State of Rio Grande do Sul-Brazil (2013) and from the Faculty of Pharmacy of the University of Porto (2019). Master in Oncology by the Institute of Biomedical Sciences Abel Salazar of the University of Porto and by the Portuguese Institute of Oncology- Porto (2015). PhD in Experimental and Clinical Pharmacology and Toxicology from the Faculty of Medicine of the University of Porto (2022). Currently Invited Assistant Professor in Department of Immunophysiology and Pharmacology ICBAS-Porto University. Blueclinical employee, collaborating in conducting phase I clinical trials.
Read full resume ↓
Identification

Personal identification

Full name
Carina Talice Stube Herman de Sousa
Gender
Feminino

Citation names

  • Herman, Carina
  • Herman-de-Sousa, Carina

Author identifiers

Ciência ID
3D1D-1828-6CD4

Email addresses

  • carina.sousa@blueclinical.pt (Profissional)
  • cherman@icbas.up.pt (Profissional)

Addresses

  • Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas Abel Salazar, University of Porto. Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Profissional)
  • Hospital da Prelada- Rua de Sarmento de Beires 153 , 4250, Porto, Porto, Portugal (Profissional)

Knowledge fields

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
Education
Degree Classification
2022/09/20
Concluído
 Experimental and Clinical Pharmacology and Toxicology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"MECHANISMS BEHIND THE PRO-FIBROTIC ROLE OF ADENOSINE IN HUMAN SUBCUTANEOUS FIBROBLASTS AND ITS CONTRIBUTION TO MYOFASCIAL PATHOLOGICAL CONDITIONS" (THESIS/DISSERTATION)
2015
Concluído
 Master's in Oncology (Mestrado)
Major in Oncologia
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 17
2013/03/06
Concluído
 Pharmaceutical Sciences (Licence)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Brasil
16
Affiliation

Ciência

Category
Host institution 		Employer
2023/01 - Current Investigador (Investigação) BlueClinical, Portugal

Docência no Ensino Superior

Category
Host institution 		Employer
2023/09 - Current Professor Auxiliar Convidado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Outros

Category
Host institution 		Employer
2022/07 - 2023/07 Researcher- Pharmacology and Drug Innovation Universitätsstadt Tübingen, Alemanha
Universidade do Porto Faculdade de Medicina, Portugal
(...)
2021/04/01 - 2022 Researcher- Pharmacology and Drug Innovation Universidade do Porto, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2021/03/31 Scholarship holder Doctoral Program Experimental and Clinical Pharmacology and Toxicology Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014 Pharmacist Panvel Farmácias, Brasil
2012 - 2013 Scholarship holder (Programa Ciências sem Fronteiras/Brasil-ERASMUS) Ministério da Educação, Brasil
Universidade do Porto Faculdade de Farmácia, Portugal
2008 - 2012 Technician (Neonatal Intensive Care Unit) Hospital de Caridade de Ijuí, Brasil
2007 - 2012 Scholarship holder (Bachelor in Pharmaceutical Sciences) Ministério da Educação, Brasil
Projects

Bolsa

Designation Funders
2021/04/01 - 2022/06/30 Unravelling the cellular and molecular cardiopulmonary benefits of DBH inhibition in animals with pulmonary arterial hypertension
PCS/BIAL/001/2019
Bolseiro de Investigação
Em curso
2017 - 2022 "Mechanisms behind the pro-fibrotic role of adenosine in human subcutaneous fibroblasts and its contribution to myofascial pathological conditions"
NORTE-69-2015-15
Bolseiro de Doutoramento
Concluído

Projeto

Designation Funders
2023/03/01 - 2024/08/31 Purinas como biomarcadores urinários e alvos terapêuticos na isquemia/reperfusão da bexiga em doentes com obstrução urinária e hiperatividade do detrusor
2022.10707.PTDC
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020 - 2023 Center for Drug Discovery and Innovative Medicines University of Porto (MedInUP)
UIDB/04308/2020
Investigador
Fundação para a Ciência e a Tecnologia
Em curso

Outro

Designation Funders
2022/07 - Current ALBINO- Effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome – a blinded randomized placebo-controlled parallel group multicenter trial for superiority (Phase III)
Ensaio clínico com o Nº EudraCT 2016-000222-19
Bolseiro de Investigação
Em curso
Outputs

Publicações

Artigo em revista
  1. Mathias, Lucas Solla; Herman-de-Sousa, Carina; Cury, Sarah Santiloni; Nogueira, Célia Regina; Correia-de-Sá, Paulo; de Oliveira, Miriane. "RNA-seq reveals that anti-obesity irisin and triiodothyronine (T3) hormones differentially affect the purinergic signaling transcriptomics in differentiated human adipocytes". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1868 4 (2023): 159276. http://dx.doi.org/10.1016/j.bbalip.2022.159276.
    10.1016/j.bbalip.2022.159276
  2. Bessa, Cláudia; Loureiro, Joana B.; Barros, Matilde; Isca, Vera M. S.; Sardão, Vilma A.; Oliveira, Paulo J.; Bernardino, Raquel L.; et al. "Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCd Activator". International Journal of Molecular Sciences 24 6 (2023): 5710. http://dx.doi.org/10.3390/ijms24065710.
    10.3390/ijms24065710
  3. Herman-de-Sousa, Carina; Costa, Maria Adelina; Silva, Rafaela Pedro; Ferreirinha, Fátima; Ribeiro, Severino; Correia-de-Sá, Paulo. "A2A receptor-induced overexpression of pannexin-1 channels indirectly mediates adenosine fibrogenic actions by favouring ATP release from human subcutaneous fibroblasts". Life Sciences 310 (2022): 121080. http://dx.doi.org/10.1016/j.lfs.2022.121080.
    10.1016/j.lfs.2022.121080
  4. Herman-de-Sousa, Carina; Pinheiro, Ana Rita; Paramos-de-Carvalho, Diogo; Costa, Maria Adelina; Ferreirinha, Fátima; Magalhães-Cardoso, Teresa; Ribeiro, Severino; et al. "Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers". Cells 9 3 (2020): 651. http://dx.doi.org/10.3390/cells9030651.
    10.3390/cells9030651
Poster em conferência
  1. Herman-de-Sousa, Carina; Mariana Ribeiro; Diogo Silva; Costa, Maria Adelina; Correia-de-Sá, Paulo. "Exploring serum adenosine and adenosine deaminase as a biomarkers of fibromyalgia severity: results from a non-interventional clinical study.". Paper presented in XIII Meeting of the Brazilian Purine Club 2024. Curitiba-Brasil, November 5-8, 2024., 2024.
  2. Herman-de-Sousa, Carina. ""Unravelling Adenosine receptors signaling in rat subcutaneous fibroblasts: a novel approach to myofascial pain"". Paper presented in IJUP 2020 - Investigação Jovem na Universidade do Porto, 2020., 2020.
  3. Herman-de-Sousa, Carina. ""Adenosine A2A receptor activation promotes fibrosis by favoring pannexin-1 overexpression in human subcutaneous fibroblasts"". Paper presented in 1st European Purine Meeting 2019, 2019.
Tese / Dissertação
  1. "Mechanisms behind pro-fibrotic role of adenosine in human subcutaneous fibroblasts and its contribution to myofascial pathological conditions.". Doutoramento, Universidade do Porto Faculdade de Medicina, 2022. https://hdl.handle.net/10216/144023.
  2. Carina Talice Stube Herman de Sousa. "Targeted therapies as a strategy in the maintence treatment of ovarian cancer: systematic review and meta-analysis of randomized clinical trials". Mestrado, 2015. https://hdl.handle.net/10216/81139.
Activities

Apresentação oral de trabalho

Presentation title Event name
Host (Event location)
2025/02/06 Diagnostic implications of adenosine and adenosine deaminase activity in the serum of fibromyalgia patients 55ª Reunião da Sociedade Portuguesa de Farmacologia, 43ª Reunião de Farmacologia Clínica e 24ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02/10 Adenosine A2A receptors promote fibrosis of the human subcutaneous tissue indirectly by Panx-1 overexpression mediating ATP release 52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia.
orto Palácio by The Editory - The Editory Collection Hotels , Av. da Boavista ,1269, 4100-130 Porto, Portugal (Porto, Portugal)
2021/02/18 THE PRO-FIBROTIC ACTION OF ADENOSINE A2A RECEPTORS IN THE HUMAN DERMIS MAYBE DUE TO OVEREXPRESSION OF PANNEXIN-1 IN DETRIMENT OF CONNEXIN 43 HEMICHANNELS IN SUBCUTANEOUS FIBROBLASTS 51.ª Reunião da Sociedade Portuguesa de Farmacologia (SPF), 39.ª Reunião de Farmacologia Clínica e 20.ª Reunião de Toxicologia
Portuguese Pharmacology Society (Lisboa, Portugal)
2020/02 Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers SPF Meeting 2020
Universidade de Coimbra, Faculdade de Farmácia (Coimbra, Portugal)
2019 ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA XXXVII REUNIÃO FARMACOLOGIA CLÍNICA XVIII REUNIÃO TOXICOLOGIA
Universidade do Porto, Faculdade de Farmácia (Porto, Portugal)
2018 ADENOSINE A2A RECEPTOR STIMULATES GROWTH AND TYPE I COLLAGEN PRODUCTION BY FIBROBLASTS OF THE HUMAN SUBCUTANEOUS TISSUE XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF), XXXVI Reunião de Farmacologia Clínica e XVII Reunião de Toxicologia-2018
Universidade de Lisboa, Faculdade de Medicina (Lisboa, Portugal)

Orientação

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09/01 - 2020/12/18 Rat subcutaneous tissue response to inflammatory stimuli is mediated through an adenosine A2A/A3 receptors heterocomplex
Coorientador
 Mestrado em Bioquímica (Mestrado)
Faculdade de Ciências Universidade do Porto, Portugal

Organização de evento

Event name
Type of event (Role) 		Institution / Organization
2022/02/09 - 2022/02/10 52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia, que se realizou de 9 a 11 de Fevereiro, no Porto. (2022/02/09 - 2022/02/11)
Conferência (Membro da Comissão Organizadora)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Participação em evento

Activity description
Type of event 		Event name
Institution / Organization
2024/11/05 - 2024/11/08 Apresentação Poster "Exploring serum adenosine and adenosine deaminase as a biomarkers of fibromyalgia severity: results from a non-interventional clinical study"
Congresso
 XIII Meeting of the Brazilian Purine Club
2019 - 2019 Apresentação de Poster "ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS"
Encontro
 First European Purine Meeting
Universidade de Santiago de Compostela Facultade de Medicina e Odontoloxía, Espanha

Júri de grau académico

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022 Drug-resistant diabetic erectile arterial dysfunction (DREAD): Is the purinome a novel therapeutic target?
Arguente principal
 Natália Beirão de Sousa (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2019 HPLC analysis of the extracellular catabolism of adenine nucleotides and nucleosides in fibroblasts of the tar right ventricle
Arguente principal
 Eduardo Veríssimo Sousa (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em conferência

Conference name Conference host
2024/02/07 - 2024/02/09 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology Universidade NOVA- Lisboa

Curso / Disciplina lecionado

Academic session Degree Subject (Type) Institution / Organization
2021/05/31 - Current Aula Teórica, Unidade Curricular de Farmacologia Molecular e Celular. "Transmembrane transport: hemichannels and P-glycoprotein" Mestrado Bioquímica- Universidade do Porto (Mestrado) Faculdade de Ciências Universidade do Porto, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/05/16 - 2023/05/19 10º Congresso Internacional em Saúde: Empreendedorismo e Inovação " Palestra: Desenvolvimento pré-clínico e clínico de fármacos em Portugal" Farmácia (Licence) Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Brasil
2021/04/19 - 2021/04/19 Aula prática: Módulo "Live Cell Imaging"- Measurements of intracellular Ca2+ using calcium-sensitive dyes: microplate reader Mestrado em Neurobiologia Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/11/25 - 2020/11/25 Open Class Presentation: "Molecular Pharmacology in the Research of New Drugs for the Treatment of Musculoskeletal Diseases". Pharmacy Course - Regional University of the Northwest of the State of Rio Grande do Sul- Brazil. November 2020. Farmácia (Licence) Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Brasil

Membro de comissão

Activity description
Role 		Institution / Organization
2022/02/09 - 2022/02/11 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology and 21st Meeting of Toxicology.
Membro
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Outro júri / avaliação

Activity description Institution / Organization
2022 - Current Juri Ano Probatório de Doutoramento Mestre Rafael António Vale Lopes Neiva "Role of the Purinome in the Crosstalk Between Cardiomyocytes and Fibroblasts Underlying Right Ventricle Remodeling in Pulmonary Arterial Hypertension" Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal