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Identificação

Identificação pessoal

Nome completo
Joaquim Fernando Tomaz Rodrigues Moita Calado

Nomes de citação

  • calado, joaquim

Identificadores de autor

Ciência ID
1D14-88A8-5A5D
ORCID iD
0000-0002-1194-3392
Formação
Grau Classificação
2020/07/03 - 2020/07/03
Concluído
 Medicina (Título de Agregado)
Especialização em Medicina; Genética
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
1998/07/17 - 2001/07/17
Concluído
 Medicina (Doutoramento)
Especialização em Medicina; Genética
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Contribuição para Clonagem do Gene NPHP1 e Estudo dos Polimorfismos dos Genes ACE I/D e AGTR1 A1166C na Suscetibilidade da Nefropatia na Diabetes Mellitus Insulino Dependente" (TESE/DISSERTAÇÃO)
 Unanimidade
1990/01/01 - 1998/07/30
Concluído
 Título de Especialista em Nefrologia pela Ordem dos Médicos e do Grau de Assistente Hospitalar de Nefrologia pelos Hospitais Civis de Lisboa (Título de especialista)
Ordem dos Médicos, Portugal

Governo da República Portuguesa Ministério da Saúde, Portugal
Dezoito vírgula nove
1981/09/01 - 1987/07
Concluído
 Medicina (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020 - Atual Investigador principal (carreira) (Investigação) Centro Hospitalar Universitário de Lisboa Central EPE Centro de Investigação, Portugal
2013 - Atual Investigador principal (carreira) (Investigação) Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2021 - Atual Professor Associado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa, Portugal
2002 - 2020 Professor Auxiliar Convidado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento 		Empregador
2005 - Atual Assistente graduado (Médica) Centro Hospitalar de Lisboa Central EPE, Portugal
Governo da República Portuguesa Ministério da Saúde, Portugal
Projetos

Bolsa

Designação Financiadores
1998 - 2002 Angiotensin Converting Enzyme Gene Polymorphism and Genetic Susceptibility to Diabetic Nephropathy.
PRAXIS XXI / SAU / 14228 / 1998
Investigador responsável
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluído

Projeto

Designação Financiadores
2020 - Atual Development of a cellular model for Familial Renal Glucosuria: evaluation of mutants and implications for the treatment of Type 2 Diabetes Mellitus
935020001
Investigador responsável
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Outro

Designação Financiadores
2021 - Atual EUROCYS Cystinuria Registry
1356 CHULC centro de investigação
Investigador responsável
Centro Hospitalar Universitário de Lisboa Central EPE Centro de Investigação, Portugal
Em curso
Produções

Publicações

Artigo em revista
  1. Barata, Rui; Fila, Marc; Dalla-Vale, Fabienne; Bogarin, Roberto; Nunes, Paula; Ramalho, José; Rueff, José; Calado, Joaquim. "Performance of the ACMG-AMP criteria in a large familial renal glucosuria cohort with identified SLC5A2 sequence variants". Clinical Genetics (2023): http://dx.doi.org/10.1111/cge.14395.
    10.1111/cge.14395
  2. Correia, Maria João; Pimpão, António B.; Fernandes, Dalila G. F.; Morello, Judit; Sequeira, Catarina O.; Calado, Joaquim; Antunes, Alexandra M. M.; et al. "Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine". Molecules 27 4 (2022): 1416. http://dx.doi.org/10.3390/molecules27041416.
    10.3390/molecules27041416
  3. Joaquim Calado; Rui Barata; Rita Lucas; Telma Francisco; Rui Gonçalves; Nuno Ribeiro; Fernando Nolasco. "The Kidney Genetics Clinic: delivering precision medicine for kidney patients". Portuguese Journal of Nephrology & Hypertension (2021): https://doi.org/10.32932/pjnh.2021.10.139.
    10.32932/pjnh.2021.10.139
  4. Oliveira, Inês; Jacinto, Raquel; Pestana, Sara; Nolasco, Fernando; Calado, Joaquim; Lopes, Susana Santos; Roxo-Rosa, Mónica. "Zebrafish model as a screen to prevent cyst inflation in autosomal dominant polycystic kidney disease". (2021): http://hdl.handle.net/10362/125091.
    https://doi.org/10.3390/ijms22169013
  5. Kidd, Kendrah; Vylet'al, Petr; Schaeffer, Céline; Olinger, Eric; Živná, Martina; Hodanová, Katerina; Robins, Victoria; et al. "Genetic and Clinical Predictors of Age of ESKD in Individuals With Autosomal Dominant Tubulointerstitial Kidney Disease Due to UMOD Mutations". (2020): http://hdl.handle.net/10362/104618.
    https://doi.org/10.1016/j.ekir.2020.06.029
  6. Menezes, Maria do Mar; Aires, Inês; Semedo, Luísa; Calado, Joaquim; Ribeiro, Francisco; Nolasco, Fernando. "An Atypical Presentation of Thrombotic Microangiopathy After Lung Transplant: A Case Report". Transplantation Proceedings 51 5 (2019): 1633-1635. http://dx.doi.org/10.1016/j.transproceed.2019.05.002.
    10.1016/j.transproceed.2019.05.002
  7. Monteiro, Pedro; Aguiar, Carlos; Matos, Pedro; Silva-Nunes, José; Birne, Rita; Branco, Patrícia; Calado, Joaquim; Melo, Miguel; Polónia, Jorge. "Efeito da empagliflozina para além do controlo glicémico: benefício cardiovascular em doentes com DMT2 e doença cardiovascular estabelecida". (2019): http://hdl.handle.net/10400.21/11124.
    10.1016/j.repc.2019.02.008
  8. Calado, Joaquim; Santos, Ana Rita; Aires, Inês; Lebre, Firmina; Nolasco, Fernando; Rueff, José; Ramalho, José. "The Na+-coupled glucose transporter SGLT2 interacts with its accessory unit MAP17 in vitro and their expressions overlap in the renal proximal tubule". FEBS Letters 592 19 (2018): 3317-3326. http://dx.doi.org/10.1002/1873-3468.13233.
    10.1002/1873-3468.13233
  9. Navarro, David; Azevedo, Ana; Sequeira, Sílvia; Ferreira, Ana Carina; Carvalho, Fernanda; Fidalgo, Teresa; Vilarinho, Laura; et al. "Atypical adult-onset methylmalonic acidemia and homocystinuria presenting as hemolytic uremic syndrome". (2018): http://hdl.handle.net/10400.18/6264.
    10.1007/s13730-017-0298-6
  10. Michael J Coady; Abdulah El Tarazi; René Santer; Pierre Bissonnette; Louis J Sasseville; Joaquim Calado; Yoann Lussier; et al. "MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2". Journal Of The American Society Of Nephrology 28 1 (2017): 85-93. https://novaresearch.unl.pt/en/publications/442be325-5e74-4432-8a8f-32a68c2a7aff.
    10.1681/ASN.2015111282
  11. Coady, Michael J.; El Tarazi, Abdulah; Santer, René; Bissonnette, Pierre; Sasseville, Louis J.; Calado, Joaquim; Lussier, Yoann; et al. "MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2". Journal of the American Society of Nephrology 28 1 (2016): 85-93. http://dx.doi.org/10.1681/asn.2015111282.
    10.1681/asn.2015111282
  12. Heilberg, Ita P feferman; Tótoli, Cláudia; Calado, Joaquim T omaz. "Adult presentation of Bartter syndrome type IV with erythrocytosis". (2015): http://www.scopus.com/inward/record.url?scp=84982840812&partnerID=8YFLogxK.
    https://doi.org/10.1590/S1679-45082015RC3013
  13. Meneses,Guida; Viana,Helena; Santos,Maria C.; Ferreira,Carina; Calado,Joaquim; Carvalho,Fernanda; Remedio,Francisco; Nolasco,Fernando. "Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy". (2015): http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100008.
  14. Aires, Inês; Fila, Marc; Polidori, David; Santos, Ana Rita; Costa, Ana Brito; Calado, Joaquim. "Determination of the Renal Threshold for Glucose Excretion in Familial Renal Glucosuria". Nephron 129 4 (2015): 300-304. http://dx.doi.org/10.1159/000381677.
    10.1159/000381677
  15. Aires,Ines; Santos,Ana Rita; Bogarin,Roberto; Genc,Gurkan; Pratas,Jorge; Ozkaya,Ozan; Carvalho,Fernanda; et al. "Disruption of urate transport in familial renal glucosuria and report on SGLT2 expression in normal and pathological kidney". (2013): http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000400006.
  16. Aires, I.; Santos, A.R.; Pratas, J.; Nolasco, F.; Calado, J.. "Hypouricaemia and hyperuricosuria in familial renal glucosuria". Clinical Kidney Journal 6 5 (2013): 523-525. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885056806&partnerID=MN8TOARS.
    10.1093/ckj/sft100
  17. Calado, Joaquim; Santer, René; Rueff, José. "Effect of kidney disease on glucose handling (including genetic defects)". Kidney International 79 (2011): S7-S13. http://dx.doi.org/10.1038/ki.2010.510.
    10.1038/ki.2010.510
  18. Joaquim Calado; René Santer; Jose Rueff. "Effect of kidney disease on glucose handling (including genetic defects)". Kidney International 79 NA (2011): S7S13-S7S13. https://novaresearch.unl.pt/en/publications/0cbfc999-af9a-4484-840e-528e1f4a2881.
  19. Aires I; Calado J. "BI-10773, a sodium-glucose cotransporter 2 inhibitor for the potential oral treatment of type 2 diabetes mellitus.". (2010): http://europepmc.org/abstract/med/20872321.
  20. Santer, R.; Calado, J.. "Familial renal glucosuria and SGLT2: From a Mendelian trait to a therapeutic target". Clinical Journal of the American Society of Nephrology 5 1 (2010): 133-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-75749094398&partnerID=MN8TOARS.
    10.2215/CJN.04010609
  21. Fidalgo, C.; Calado, J.; Cravo, M.. "Secondary amyloidosis in a patient with long duration crohn's disease treated with infliximab". BioDrugs 24 SUPPL. 1 (2010): 15-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650483395&partnerID=MN8TOARS.
    10.2165/11586250-000000000-00000
  22. Calado J. "Dapagliflozin, an oral sodium glucose cotransporter type 2 inhibitor for the treatment of type 2 diabetes mellitus.". (2009): http://europepmc.org/abstract/med/19943222.
  23. Joaquim Calado. "Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations, and further evidence of volume depletion". Nephrology Dialysis Transplantation 23 12 (2008): 874-3879. https://novaresearch.unl.pt/en/publications/229e7ed2-120c-4ce3-ad8a-0c9cf8c1f529.
  24. Brum, S.; Rueff, J.; Santos Joao R., J.R.; Calado, J.. "Unusual adult-onset manifestation of an attenuated Bartter's syndrome type IV renal phenotype caused by a mutation in BSND [13]". Nephrology Dialysis Transplantation 22 1 (2007): 288-289. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846108259&partnerID=MN8TOARS.
    10.1093/ndt/gfl493
  25. Calado, J.; Loeffler, J.; Sakallioglu, O.; Gok, F.; Lhotta, K.; Barata, J.; Rueff, J.. "Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting". Kidney International 69 5 (2006): 852-855. http://dx.doi.org/10.1038/sj.ki.5000194.
    10.1038/sj.ki.5000194
  26. Calado, Joaquim; Gaspar, Augusta; Clemente, Carla; Rueff, José. "A novel heterozygous missense mutation in the UMOD gene responsible for Familial Juvenile Hyperuricemic Nephropathy". (2005): http://hdl.handle.net/10362/23567.
    https://doi.org/10.1186/1471-2350-6-5
  27. Calado, J.; Gaspar, A.; Clemente, C.; Rueff, J.. "A novel heterozygous missense mutation in the UMOD gene responsible for Familial Juvenile Hyperuricemic Nephropathy". BMC Medical Genetics 6 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-26444591591&partnerID=MN8TOARS.
    10.1186/1471-2350-6-5
  28. Joaquim Calado; Soto K; Clemente C; Correia P; Rueff J. "Gene Symbol: SLC55A2. Disease: familial renal glucosuria.". Human genetics 115 2 (2004):
  29. Calado, Joaquim; Soto, Karina; Clemente, Carla; Correia, Pedro; Rueff, Jos¿. "Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria". Human Genetics 114 3 (2004): 314-316. http://dx.doi.org/10.1007/s00439-003-1054-x.
    10.1007/s00439-003-1054-x
  30. Calado, J.; Soto, K.; Clemente, C.; Correia, P.; Rueff, J.. "Gene Symbol: SLC55A2. Disease: familial renal glucosuria.". Human genetics 115 2 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-4344695740&partnerID=MN8TOARS.
  31. Saunier, Sophie; Calado, Joaquim; Benessy, France; Silbermann, Flora; Heilig, Roland; Weissenbach, Jean; Antignac, Corinne. "Characterization of the NPHP1 Locus: Mutational Mechanism Involved in Deletions in Familial Juvenile Nephronophthisis". The American Journal of Human Genetics 66 3 (2000): 778-789. http://dx.doi.org/10.1086/302819.
    10.1086/302819
  32. M Konrad; S Saunier; Joaquim Calado; M C Gubler; M Broyer; C Antignac. "Familial juvenile nephronophthisis". Journal of molecular medicine (Berlin, Germany) 76 5 (1998): 310-6. https://novaresearch.unl.pt/en/publications/f47fe3ce-2e25-41b2-ab16-111ea1d4b6b8.
  33. Konrad, M.; Saunier, Sophie; Calado, Joaquim; Gubler, Marie-Claire; Broyer, Michel; Antignac, Corinne. "Familial juvenile nephronophthisis". Journal of Molecular Medicine 76 5 (1998): 310-316. http://dx.doi.org/10.1007/s001090050222.
    10.1007/s001090050222
  34. Saunier, S. "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis". Human Molecular Genetics 6 13 (1997): 2317-2323. http://dx.doi.org/10.1093/hmg/6.13.2317.
    10.1093/hmg/6.13.2317
  35. Konrad, M. "Large homozygous deletions of the 2q13 region are a major cause of juvenile nephronophthisis". Human Molecular Genetics 5 3 (1996): 367-371. http://dx.doi.org/10.1093/hmg/5.3.367.
    10.1093/hmg/5.3.367
Relatório
  1. Messias,Ana; Calado,Joaquim; Viana,Helena; Nolasco,Fernando. 2019. Nephrotic syndrome in a patient with metastatic melanoma: beyond the obvious. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000400013.
  2. Costa,Bernardo M; Calado,Joaquim; Navarro,David; Nolasco,Fernando. 2016. Bartter syndrome - report of an unusual late presentation case and brief review. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000100008.

Outros

Outra produção
  1. Performance of the Acmg-amp Criteria in a Large Familial Renal Glucosuria Cohort with Identified Slc5a2 Sequence Variants. 2023. R Barata; M Fila; F Vale; R Bogorin; P Nunes; Ramalho JS; Jose Rueff; Joaquim Calado. https://novaresearch.unl.pt/en/publications/afe97a8e-f9db-45d9-805d-d5b3f812d4db.
  2. Alternative pathway complement activation in secondary thrombotic microangiopathies: is genetics the smoking gun?. 2019. Calado,Joaquim. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000400009.
  3. Fighting glomerular hegemony: giving the renal tubule the credits it deserves. 2018. Calado,Joaquim. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100002.
  4. DETERMINATION OF THE RENAL THRESHOLD FOR GLUCOSE EXCRETION IN FAMILIAL RENAL GLUCOSURIC PATIENTS. 2014. Joaquim Calado; Jose Rueff; fernando nolasco. https://novaresearch.unl.pt/en/publications/0342ad81-7ed9-4bfa-bd2f-7b50946c6c79.
  5. It's an anti-hyperglycaemic¿ It's a diuretic¿ It's SGLT2 inhibition!. 2013. Aires,Ines; Calado,Joaquim. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000300001.