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Identification

Personal identification

Full name
Joaquim Fernando Tomaz Rodrigues Moita Calado

Citation names

  • calado, joaquim

Author identifiers

Ciência ID
1D14-88A8-5A5D
ORCID iD
0000-0002-1194-3392
Education
Degree Classification
2020/07/03 - 2020/07/03
Concluded
 Medicina (Título de Agregado)
Major in Medicina; Genética
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
1998/07/17 - 2001/07/17
Concluded
 Medicina (Doutoramento)
Major in Medicina; Genética
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Contribuição para Clonagem do Gene NPHP1 e Estudo dos Polimorfismos dos Genes ACE I/D e AGTR1 A1166C na Suscetibilidade da Nefropatia na Diabetes Mellitus Insulino Dependente" (THESIS/DISSERTATION)
 Unanimidade
1990/01/01 - 1998/07/30
Concluded
 Título de Especialista em Nefrologia pela Ordem dos Médicos e do Grau de Assistente Hospitalar de Nefrologia pelos Hospitais Civis de Lisboa (Título de especialista)
Ordem dos Médicos, Portugal

Governo da República Portuguesa Ministério da Saúde, Portugal
Dezoito vírgula nove
1981/09/01 - 1987/07
Concluded
 Medicina (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
Affiliation

Science

Category
Host institution 		Employer
2020 - Current Principal Investigator (Research) Centro Hospitalar Universitário de Lisboa Central EPE Centro de Investigação, Portugal
2013 - Current Principal Investigator (Research) Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021 - Current Associate Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa, Portugal
2002 - 2020 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa, Portugal

Other Careers

Category
Host institution 		Employer
2005 - Current Assistente graduado (Médica) Centro Hospitalar de Lisboa Central EPE, Portugal
Governo da República Portuguesa Ministério da Saúde, Portugal
Projects

Grant

Designation Funders
1998 - 2002 Angiotensin Converting Enzyme Gene Polymorphism and Genetic Susceptibility to Diabetic Nephropathy.
PRAXIS XXI / SAU / 14228 / 1998
Principal investigator
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded

Contract

Designation Funders
2020 - Current Development of a cellular model for Familial Renal Glucosuria: evaluation of mutants and implications for the treatment of Type 2 Diabetes Mellitus
935020001
Principal investigator
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Other

Designation Funders
2021 - Current EUROCYS Cystinuria Registry
1356 CHULC centro de investigação
Principal investigator
Centro Hospitalar Universitário de Lisboa Central EPE Centro de Investigação, Portugal
Ongoing
Outputs

Publications

Journal article
  1. Barata, Rui; Fila, Marc; Dalla-Vale, Fabienne; Bogarin, Roberto; Nunes, Paula; Ramalho, José; Rueff, José; Calado, Joaquim. "Performance of the ACMG-AMP criteria in a large familial renal glucosuria cohort with identified SLC5A2 sequence variants". Clinical Genetics (2023): http://dx.doi.org/10.1111/cge.14395.
    10.1111/cge.14395
  2. Correia, Maria João; Pimpão, António B.; Fernandes, Dalila G. F.; Morello, Judit; Sequeira, Catarina O.; Calado, Joaquim; Antunes, Alexandra M. M.; et al. "Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine". Molecules 27 4 (2022): 1416. http://dx.doi.org/10.3390/molecules27041416.
    10.3390/molecules27041416
  3. Joaquim Calado; Rui Barata; Rita Lucas; Telma Francisco; Rui Gonçalves; Nuno Ribeiro; Fernando Nolasco. "The Kidney Genetics Clinic: delivering precision medicine for kidney patients". Portuguese Journal of Nephrology & Hypertension (2021): https://doi.org/10.32932/pjnh.2021.10.139.
    10.32932/pjnh.2021.10.139
  4. Oliveira, Inês; Jacinto, Raquel; Pestana, Sara; Nolasco, Fernando; Calado, Joaquim; Lopes, Susana Santos; Roxo-Rosa, Mónica. "Zebrafish model as a screen to prevent cyst inflation in autosomal dominant polycystic kidney disease". (2021): http://hdl.handle.net/10362/125091.
    https://doi.org/10.3390/ijms22169013
  5. Kidd, Kendrah; Vylet'al, Petr; Schaeffer, Céline; Olinger, Eric; Živná, Martina; Hodanová, Katerina; Robins, Victoria; et al. "Genetic and Clinical Predictors of Age of ESKD in Individuals With Autosomal Dominant Tubulointerstitial Kidney Disease Due to UMOD Mutations". (2020): http://hdl.handle.net/10362/104618.
    https://doi.org/10.1016/j.ekir.2020.06.029
  6. Menezes, Maria do Mar; Aires, Inês; Semedo, Luísa; Calado, Joaquim; Ribeiro, Francisco; Nolasco, Fernando. "An Atypical Presentation of Thrombotic Microangiopathy After Lung Transplant: A Case Report". Transplantation Proceedings 51 5 (2019): 1633-1635. http://dx.doi.org/10.1016/j.transproceed.2019.05.002.
    10.1016/j.transproceed.2019.05.002
  7. Monteiro, Pedro; Aguiar, Carlos; Matos, Pedro; Silva-Nunes, José; Birne, Rita; Branco, Patrícia; Calado, Joaquim; Melo, Miguel; Polónia, Jorge. "Efeito da empagliflozina para além do controlo glicémico: benefício cardiovascular em doentes com DMT2 e doença cardiovascular estabelecida". (2019): http://hdl.handle.net/10400.21/11124.
    10.1016/j.repc.2019.02.008
  8. Calado, Joaquim; Santos, Ana Rita; Aires, Inês; Lebre, Firmina; Nolasco, Fernando; Rueff, José; Ramalho, José. "The Na+-coupled glucose transporter SGLT2 interacts with its accessory unit MAP17 in vitro and their expressions overlap in the renal proximal tubule". FEBS Letters 592 19 (2018): 3317-3326. http://dx.doi.org/10.1002/1873-3468.13233.
    10.1002/1873-3468.13233
  9. Navarro, David; Azevedo, Ana; Sequeira, Sílvia; Ferreira, Ana Carina; Carvalho, Fernanda; Fidalgo, Teresa; Vilarinho, Laura; et al. "Atypical adult-onset methylmalonic acidemia and homocystinuria presenting as hemolytic uremic syndrome". (2018): http://hdl.handle.net/10400.18/6264.
    10.1007/s13730-017-0298-6
  10. Michael J Coady; Abdulah El Tarazi; René Santer; Pierre Bissonnette; Louis J Sasseville; Joaquim Calado; Yoann Lussier; et al. "MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2". Journal Of The American Society Of Nephrology 28 1 (2017): 85-93. https://novaresearch.unl.pt/en/publications/442be325-5e74-4432-8a8f-32a68c2a7aff.
    10.1681/ASN.2015111282
  11. Coady, Michael J.; El Tarazi, Abdulah; Santer, René; Bissonnette, Pierre; Sasseville, Louis J.; Calado, Joaquim; Lussier, Yoann; et al. "MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2". Journal of the American Society of Nephrology 28 1 (2016): 85-93. http://dx.doi.org/10.1681/asn.2015111282.
    10.1681/asn.2015111282
  12. Heilberg, Ita P feferman; Tótoli, Cláudia; Calado, Joaquim T omaz. "Adult presentation of Bartter syndrome type IV with erythrocytosis". (2015): http://www.scopus.com/inward/record.url?scp=84982840812&partnerID=8YFLogxK.
    https://doi.org/10.1590/S1679-45082015RC3013
  13. Meneses,Guida; Viana,Helena; Santos,Maria C.; Ferreira,Carina; Calado,Joaquim; Carvalho,Fernanda; Remedio,Francisco; Nolasco,Fernando. "Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy". (2015): http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100008.
  14. Aires, Inês; Fila, Marc; Polidori, David; Santos, Ana Rita; Costa, Ana Brito; Calado, Joaquim. "Determination of the Renal Threshold for Glucose Excretion in Familial Renal Glucosuria". Nephron 129 4 (2015): 300-304. http://dx.doi.org/10.1159/000381677.
    10.1159/000381677
  15. Aires,Ines; Santos,Ana Rita; Bogarin,Roberto; Genc,Gurkan; Pratas,Jorge; Ozkaya,Ozan; Carvalho,Fernanda; et al. "Disruption of urate transport in familial renal glucosuria and report on SGLT2 expression in normal and pathological kidney". (2013): http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000400006.
  16. Aires, I.; Santos, A.R.; Pratas, J.; Nolasco, F.; Calado, J.. "Hypouricaemia and hyperuricosuria in familial renal glucosuria". Clinical Kidney Journal 6 5 (2013): 523-525. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885056806&partnerID=MN8TOARS.
    10.1093/ckj/sft100
  17. Calado, Joaquim; Santer, René; Rueff, José. "Effect of kidney disease on glucose handling (including genetic defects)". Kidney International 79 (2011): S7-S13. http://dx.doi.org/10.1038/ki.2010.510.
    10.1038/ki.2010.510
  18. Joaquim Calado; René Santer; Jose Rueff. "Effect of kidney disease on glucose handling (including genetic defects)". Kidney International 79 NA (2011): S7S13-S7S13. https://novaresearch.unl.pt/en/publications/0cbfc999-af9a-4484-840e-528e1f4a2881.
  19. Aires I; Calado J. "BI-10773, a sodium-glucose cotransporter 2 inhibitor for the potential oral treatment of type 2 diabetes mellitus.". (2010): http://europepmc.org/abstract/med/20872321.
  20. Santer, R.; Calado, J.. "Familial renal glucosuria and SGLT2: From a Mendelian trait to a therapeutic target". Clinical Journal of the American Society of Nephrology 5 1 (2010): 133-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-75749094398&partnerID=MN8TOARS.
    10.2215/CJN.04010609
  21. Fidalgo, C.; Calado, J.; Cravo, M.. "Secondary amyloidosis in a patient with long duration crohn's disease treated with infliximab". BioDrugs 24 SUPPL. 1 (2010): 15-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650483395&partnerID=MN8TOARS.
    10.2165/11586250-000000000-00000
  22. Calado J. "Dapagliflozin, an oral sodium glucose cotransporter type 2 inhibitor for the treatment of type 2 diabetes mellitus.". (2009): http://europepmc.org/abstract/med/19943222.
  23. Joaquim Calado. "Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations, and further evidence of volume depletion". Nephrology Dialysis Transplantation 23 12 (2008): 874-3879. https://novaresearch.unl.pt/en/publications/229e7ed2-120c-4ce3-ad8a-0c9cf8c1f529.
  24. Brum, S.; Rueff, J.; Santos Joao R., J.R.; Calado, J.. "Unusual adult-onset manifestation of an attenuated Bartter's syndrome type IV renal phenotype caused by a mutation in BSND [13]". Nephrology Dialysis Transplantation 22 1 (2007): 288-289. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846108259&partnerID=MN8TOARS.
    10.1093/ndt/gfl493
  25. Calado, J.; Loeffler, J.; Sakallioglu, O.; Gok, F.; Lhotta, K.; Barata, J.; Rueff, J.. "Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting". Kidney International 69 5 (2006): 852-855. http://dx.doi.org/10.1038/sj.ki.5000194.
    10.1038/sj.ki.5000194
  26. Calado, Joaquim; Gaspar, Augusta; Clemente, Carla; Rueff, José. "A novel heterozygous missense mutation in the UMOD gene responsible for Familial Juvenile Hyperuricemic Nephropathy". (2005): http://hdl.handle.net/10362/23567.
    https://doi.org/10.1186/1471-2350-6-5
  27. Calado, J.; Gaspar, A.; Clemente, C.; Rueff, J.. "A novel heterozygous missense mutation in the UMOD gene responsible for Familial Juvenile Hyperuricemic Nephropathy". BMC Medical Genetics 6 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-26444591591&partnerID=MN8TOARS.
    10.1186/1471-2350-6-5
  28. Joaquim Calado; Soto K; Clemente C; Correia P; Rueff J. "Gene Symbol: SLC55A2. Disease: familial renal glucosuria.". Human genetics 115 2 (2004):
  29. Calado, Joaquim; Soto, Karina; Clemente, Carla; Correia, Pedro; Rueff, Jos¿. "Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria". Human Genetics 114 3 (2004): 314-316. http://dx.doi.org/10.1007/s00439-003-1054-x.
    10.1007/s00439-003-1054-x
  30. Calado, J.; Soto, K.; Clemente, C.; Correia, P.; Rueff, J.. "Gene Symbol: SLC55A2. Disease: familial renal glucosuria.". Human genetics 115 2 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-4344695740&partnerID=MN8TOARS.
  31. Saunier, Sophie; Calado, Joaquim; Benessy, France; Silbermann, Flora; Heilig, Roland; Weissenbach, Jean; Antignac, Corinne. "Characterization of the NPHP1 Locus: Mutational Mechanism Involved in Deletions in Familial Juvenile Nephronophthisis". The American Journal of Human Genetics 66 3 (2000): 778-789. http://dx.doi.org/10.1086/302819.
    10.1086/302819
  32. M Konrad; S Saunier; Joaquim Calado; M C Gubler; M Broyer; C Antignac. "Familial juvenile nephronophthisis". Journal of molecular medicine (Berlin, Germany) 76 5 (1998): 310-6. https://novaresearch.unl.pt/en/publications/f47fe3ce-2e25-41b2-ab16-111ea1d4b6b8.
  33. Konrad, M.; Saunier, Sophie; Calado, Joaquim; Gubler, Marie-Claire; Broyer, Michel; Antignac, Corinne. "Familial juvenile nephronophthisis". Journal of Molecular Medicine 76 5 (1998): 310-316. http://dx.doi.org/10.1007/s001090050222.
    10.1007/s001090050222
  34. Saunier, S. "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis". Human Molecular Genetics 6 13 (1997): 2317-2323. http://dx.doi.org/10.1093/hmg/6.13.2317.
    10.1093/hmg/6.13.2317
  35. Konrad, M. "Large homozygous deletions of the 2q13 region are a major cause of juvenile nephronophthisis". Human Molecular Genetics 5 3 (1996): 367-371. http://dx.doi.org/10.1093/hmg/5.3.367.
    10.1093/hmg/5.3.367
Report
  1. Messias,Ana; Calado,Joaquim; Viana,Helena; Nolasco,Fernando. 2019. Nephrotic syndrome in a patient with metastatic melanoma: beyond the obvious. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000400013.
  2. Costa,Bernardo M; Calado,Joaquim; Navarro,David; Nolasco,Fernando. 2016. Bartter syndrome - report of an unusual late presentation case and brief review. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000100008.

Other

Other output
  1. Performance of the Acmg-amp Criteria in a Large Familial Renal Glucosuria Cohort with Identified Slc5a2 Sequence Variants. 2023. R Barata; M Fila; F Vale; R Bogorin; P Nunes; Ramalho JS; Jose Rueff; Joaquim Calado. https://novaresearch.unl.pt/en/publications/afe97a8e-f9db-45d9-805d-d5b3f812d4db.
  2. Alternative pathway complement activation in secondary thrombotic microangiopathies: is genetics the smoking gun?. 2019. Calado,Joaquim. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000400009.
  3. Fighting glomerular hegemony: giving the renal tubule the credits it deserves. 2018. Calado,Joaquim. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100002.
  4. DETERMINATION OF THE RENAL THRESHOLD FOR GLUCOSE EXCRETION IN FAMILIAL RENAL GLUCOSURIC PATIENTS. 2014. Joaquim Calado; Jose Rueff; fernando nolasco. https://novaresearch.unl.pt/en/publications/0342ad81-7ed9-4bfa-bd2f-7b50946c6c79.
  5. It's an anti-hyperglycaemic¿ It's a diuretic¿ It's SGLT2 inhibition!. 2013. Aires,Ines; Calado,Joaquim. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000300001.