Filipa Fernandes Mendes (1711-EA6A-041A)

Curriculum Vitae

Filipa Fernandes Mendes

Filipa Fernandes Mendes is a Principal Researcher (with tenure) at Universidade de Lisboa, Instituto Superior Técnico, Department of Nuclear Sciences and Engineering. Her scientific activity is developed at C2TN - Center for Nuclear Sciences and Technologies, where she is currently the Coordinator of the thematic strand "Radiopharmaceutical Sciences and Health Physics" and a member of the Coordinating Commission of the Scientific Council (CC-CC). Filipa Mendes is focused on merging advances in molecular biology with chemistry (radiopharmaceutical and medicinal) to advance molecular and biomedical imaging and therapy. Given her training and experience in molecular and cellular biology, present research interests are the understanding of the biological mechanisms and molecular interactions of radioactive compounds useful as probes for in vivo molecular imaging and/or targeted radiotherapy. She has extended the evaluation of cancer theranostic compounds (suitable for diagnosis and therapy) to 3D cellular models of cancer, and she is currently Editor of a Research Topic on the journal Frontiers in Molecular Biosciences on this subject. Moreover, she is interested in the development of novel molecular tools for the study of ABC transporters involved in human diseases, such as Cystic Fibrosis and Cancer Multidrug Resistance. She is the author of 68 articles in peer-reviewed journals (90% in Q1), 18 of which as senior author. She has over 1650 citations (H index 24 and i10 index 50) and was/is the PI of 3 FCT funded projects (including 1 Bilateral with France) and 1 industry research contract. Filipa Mendes has supervised 5 MSc and 1 PhD to completion and currently supervises/co-supervises 3 MSc and 3 PhD students. Since 2014 she teaches at the Department of Bioengineering, Instituto Superior Técnico, the courses Genetic Engineering and Molecular Biotechnology, and she has received several Excellence in Teaching diplomas.

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Identificação

Identificação pessoal

Nome completo: Filipa Fernandes Mendes

Nomes de citação

Mendes, Filipa

Identificadores de autor

Ciência ID: 1711-EA6A-041A
ORCID iD: 0000-0003-0646-1687
Researcher Id: B-2057-2010
Scopus Author Id: 36465350400

Endereços de correio eletrónico

fmendes@ctn.tecnico.ulisboa.pt (Profissional)

Moradas

C2TN- Centro Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Profissional)
DECN- Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Profissional)

Websites

http://c2tn.tecnico.ulisboa.pt/index.php/r-d/research-groups/radiopharmaceutical-sciences/rs-home (Profissional)
https://fenix.tecnico.ulisboa.pt/homepage/ist25493 (Académico)

Domínios de atuação

Ciências Médicas e da Saúde - Biotecnologia Médica
Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Ciências Naturais - Ciências Biológicas - Biologia Celular
Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Francês	Utilizador elementar (A1)	Utilizador independente (B1)	Utilizador elementar (A1)	Utilizador elementar (A1)
Espanhol; Castelhano	Utilizador elementar (A2)	Utilizador independente (B1)	Utilizador elementar (A1)	Utilizador independente (B1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2020/09/07 - 2020/09/18 Concluído	Gestão de equipas / Team management (Outros) Companhia Própria - Formação e Consultoria, Portugal	na
2008 - 2008 Concluído	Edicção e Revisão de texto / Text Edition and Revision (Outros) Universidade Católica Portuguesa, Portugal
2000 - 2004 Concluído	Biologia / Biology (Doutoramento) Especialização em Biologia Celular / Cell Biology Universidade de Lisboa Faculdade de Ciências, Portugal "Expression, Localization and Traffic of Wild-Type and Mutant CFTR Protein" (TESE/DISSERTAÇÃO)	PhD Summa cum laude (Aprovada com distinção e louvor)
1994 - 1999 Concluído	Biologia - Biologia Microbiana e Genética / Biology - Microbiology and Genetics (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal "Cystic fibrosis: Expression and Intracellular localization of CFTR protein" (TESE/DISSERTAÇÃO)	18

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/02/01 - Atual	Investigador principal (carreira) (Investigação)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/01/01 - 2023/01/31	Investigador Auxiliar (carreira) (Investigação)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
	Universidade de Lisboa Departamento de Engenharia e Ciências Nucleares, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2013/09/01 - Atual	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Lisboa Instituto Superior Técnico, Portugal

2014/02/17 - 2014/06/30	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Lisboa Faculdade de Ciências, Portugal
	Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
2008/04/01 - 2012/05/01	Professor Auxiliar Convidado (Docente Universitário)	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2021/04 - Atual	Coordinator of the Health Thematic Line, C2TN Research Unit	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

2021/04 - Atual	Member of the Coordinating Council, C2TN Research Unit	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2013/09/01 - 2015/12/31	Principal Investigator – “FCT Investigator” Development Grant (Life and Health Sciences)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

2008/09/01 - 2013/08/31	Research Scientist - Ciência 2007	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

2005/01/01 - 2008/07/01	Post-doctoral Fellow	Universidade de Lisboa Faculdade de Ciências, Portugal

2000/01/01 - 2004/12/31	PhD Student	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

2001/05/01 - 2003/08/31	Visiting Graduate Student	University of Virginia Department of Biology, Estados Unidos

1998/09/01 - 1999/07/30	Undergraduate Trainee	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Projetos

Projeto

	Designação	Financiadores
2021/03/01 - Atual	Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer PTDC/QUI-QIN/0146/2020 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2020/01/01 - Atual	In-beam Time-of-Flight (TOF) Positron Emission Tomography (PET) for proton radiation therapy LISBOA-01-0247-FEDER-045904 Investigador Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/04 - 2024/03	A novel nanoplatform for melanoma targeting with hydroxyquinoline metal complexes PTDC/QUI-QIN/0586/2020 Investigador	Em curso
2022 - 2024	Targeted radiotherapy of radioresistant cancers – a radiobiological study with advanced cell models 2021.09137.CBM Investigador responsável	Em curso
2021/01/01 - 2023/12/31	Organelle-targeted Radiocomplexes for Auger Therapy of Cancer PTDC/MED-QUI/1554/2020 Co-Principal Investigator	Fundação para a Ciência e a Tecnologia Em curso
2018/09/01 - 2022/07/31	Targeting the transporters of cationic amino acids for cancer radiotheranostics: experimental and computational chemistry approach PTDC/QUI-NUC/30147/2017- FCT Investigador Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/08/01 - 2022/07/31	Novel Molecular Imaging tools for Cystic Fibrosis PTDC/BTM-TEC/29256/2017 Investigador responsável Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2015/04 - 2018	Validation of novel tools for detection of CFTR CF antibodies Investigador responsável Universidade de Lisboa Instituto Superior Técnico, Portugal	ProQR Therapeutics NV Concluído
2013/06 - 2016/05	Molecular and Nano Tools for Cancer Theranostics 126789 Provided by PTCRIS: 126789 Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P.
2014/04 - 2015/03	Dual Targeting Strategy for EGFR Positive Tumors 134975 Provided by PTCRIS: 134975 Investigador Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2012/03 - 2015/02	Preclinical evaluation of ruthenium potential drugs for cancer therapy info:eu-repo/grantAgreement/FCT/3599-PPCDT/118077/PT Investigador Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2015	Functional metal complexes that bind to biomolecules COST Action CM1105 Investigador Centro de Ciências e Tecnologias Nucleares, Portugal	Concluído
2012 - 2015	Nitric Oxide Synthase targeting with Re(I)/99mTc(I)-complexes containing L-Arg derivatives: A structure-activity study PTDC/QUI-QUI/121752/2010 Investigador Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/03 - 2014/08	Targeting telomerase inhibition with new anti-tumoral Cu(II) complexes Provided by PTCRIS: 114139 114139 Investigador Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2013/07 - 2014/06	A Molecular Imaging Approach to Cystic Fibrosis 124308 Provided by PTCRIS: 124308 Investigador responsável Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2012 - 2014	Target-specific and Heterobimetallic Platinum Complexes: Synthesis, Characterization and Mechanistic Studies E-23/12 Investigador Universidade de Lisboa Faculdade de Ciências, Portugal	Concluído
2010 - 2012	Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation PTDC/QUI-QUI/102049/2008 Investigador Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009 - 2010	Metallo-drug design and action COST Action D39 Investigador
2007 - 2008	A novel insight into CFTR Phosphorylation: implications for its processing, trafficking and function PTDC/BIA-BCM/67058/2006 Investigador Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007 - 2008	Novel post-genomic cell-based screens for drug targeting in membrane protein disorders- TargetScreen2 EU FP6-LSH-2005-037365 Investigador Pós-doutorado Universidade de Lisboa Faculdade de Ciências, Portugal	European Commission Sixth Framework Programme Concluído
2002 - 2004	In search of new molecular targets for the development of novel therapeutic strategies for cystic fibrosis POCTI/MGI/40878/2001 Outra Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2000 - 2003	Thematic Network around Cystic Fibrosis and Related Diseases EU FP5-QLK3-1999-00241	European Commission Sixth Framework Programme
2001/02/01 - 2002	Biogenesis and function of CFTR protein with different mutations: molecular basis for clinical and therapeutic heterogeneity of Cystic Fibrosis? info:eu-repo/grantAgreement/FCT/POCI/35737/PT Outra Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal	Universidade do Algarve Faculdade de Ciências e Tecnologia Concluído
1999 - 1999	Cystic Fibrosis - traffic and cellular function of CFTR PRAXIS/PSAU/C/SAU/55/96	Fundação para a Ciência e a Tecnologia

Produções

Publicações

Artigo em conferência	Antunes, Joana; Mendes, Filipa; Paulo, António; Sampaio, Jorge. "Modeling the radiobiological effects of gold nanoparticles in proton therapy of glioblastomas". 2021. 10.22323/1.380.0040 Di Maria S; Belchior, A.; Pereira, Edgar; Do Quental, L.; Oliveira, MC; Mendes, Filipa; Lavrado, J.; Paulo, António; Vaz, P.. "Dosimetry assessment of DNA damage by Auger-emitting radionuclides: Experimental and Monte Carlo studies". 2017. Publicado • 10.1016/j.radphyschem.2017.01.028 Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Perfusion and specific radioprobes for cardiac imaging". Trabalho apresentado em CARDIOTECHNIX 2013 - International Congress on Cardiovascular Technologies, Vilamoura, 2013. Publicado
Artigo em revista	Carina Marques Coelho; Lia Pereira; Pamela Teubig; Pedro Santos; Filipa Mendes; Sílvia Viñals; Daniel Galaviz; Federico Herrera. "Radiation as a Tool against Neurodegeneration—A Potential Treatment for Amyloidosis in the Central Nervous System". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232012265. 10.3390/ijms232012265 Matos, Cristina P.; Albino, Melissa; Lopes, Joana; Viana, Ana Silveira; Côrte-Real, Leonor; Mendes, Filipa; Pessoa, João Costa; et al. "New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes". International Journal of Pharmaceutics 623 (2022): 121925. http://dx.doi.org/10.1016/j.ijpharm.2022.121925. 10.1016/j.ijpharm.2022.121925 Célia Fernandes; Elisa Palma; Francisco Silva; Ana Belchior; Catarina I. G. Pinto; Joana F. Guerreiro; Hugo M. Botelho; et al. "Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus". International Journal of Molecular Sciences 23 13 (2022): 7238-7238. https://doi.org/10.3390/ijms23137238. 10.3390/ijms23137238 Ana B. Buades; Laura C. J. Pereira; Bruno J. C. Vieira; Ana C. Cerdeira; João C. Waerenborgh; Teresa Pinheiro; António P. A. Matos; et al. "The Mössbauer effect using 57Fe-ferrabisdicarbollide ([o-57FESAN]-): a glance into the potential of a low-dose approach for glioblastoma radiotherapy". Inorganic Chemistry Frontiers (2022): https://doi.org/10.1039/D1QI01513C. 10.1039/D1QI01513C Miquel Nuez-Martinez; Catarina I. G. Pinto; Joana F. Guerreiro; Filipa Mendes; Fernanda Marques; Amanda Muñoz-Juan; Jewel Ann Maria Xavier; et al. "Cobaltabis(dicarbollide) ([o-COSAN]-) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma". Cancers (2021): https://doi.org/10.3390/cancers13246367. 10.3390/cancers13246367 Palma, Elisa; Raposinho, Paula; Cabral Campello, Maria Paula; Belo, Dulce; Guerreiro, Joana; Alves, Vitor; Fonseca, Alexandra; et al. "Anticancer Activity and Mode of Action of Copper (II)- Bisthiosemicarbazonato Complexes with Pendant Nitrogen Heterocycles". European Journal of Inorganic Chemistry (2021): http://dx.doi.org/10.1002/ejic.202100168. Aceite para publicação • 10.1002/ejic.202100168 Vera F. C. Ferreira; Bruno L. Oliveira; Alice D’Onofrio; Carlos M. Farinha; Lurdes Gano; António Paulo; Gonçalo J. L. Bernardes; Filipa Mendes. "In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00551. 10.1021/acs.bioconjchem.0c00551 Ben Woods; Rúben D. M. Silva; Claudia Schmidt; Darren Wragg; Marco Cavaco; Vera Neves; Vera F. C. Ferreira; et al. "Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00659. 10.1021/acs.bioconjchem.0c00659 D'Onofrio, A.; Gano, L.; Melo, R.; Mendes, F.; Oliveira, M.C.; Denoël, T.; Schaefer, N.; et al. "Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 158 (2021): 233-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099854769&partnerID=MN8TOARS. 10.1016/j.ejpb.2020.11.015 Ferreira, VFC; Correia, JDG; Farinha, CMF; Mendes, Filipa. "Improved Fmoc-solid-phase peptide synthesis of an extracellular loop of CFTR for antibody selection by the phage display technology". Journal of Peptide Science (2020): Aceite para publicação • PSC-20-0035 Tabacaru, A.; Dediu, A.V.B.; Dinica, R.M.; Carac, G.; Basliu, V.; Campello, M.P.C.; Silva, FFA; et al. "Biological properties of a new mixed lanthanide(III) complex incorporating a dypiridinium ylide". Inorganica Chimica Acta 506 (2020): http://dx.doi.org/10.1016/j.ica.2020.119517. No prelo • 10.1016/j.ica.2020.119517 Mendes, Filipa; Gano, Lurdes; Grilo, J; Cunha, S; Fernandes, C.; Paulo, A.. "Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance". Cancer Drug Resistance (2020): http://dx.doi.org/10.20517/cdr.2019.86. Acesso aberto • Publicado • 10.20517/cdr.2019.86 Guerreiro, J.F.; Gomes, M.A.G.B.; Pagliari, F.; Jansen, J.; Marafioti, M.G.; Nistico, C.; Hanley, R.; et al. "Iron and copper complexes with antioxidant activity as inhibitors of the metastatic potential of glioma cells". RSC Advances 10 22 (2020): 12699-12710. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083395557&partnerID=MN8TOARS. 10.1039/d0ra00166j Pinto, C.I.G.; Bucar, S.; Alves, V.; Fonseca, A.; Abrunhosa, A.J.; da Silva, C.L.; Guerreiro, J.F.; Mendes, F.. "Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer". Frontiers in Molecular Biosciences 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85097663129&partnerID=MN8TOARS. 10.3389/fmolb.2020.609172 Alvarez-Valdes, A.; Matesanz, A.I.; Perles, J.; Fernandes, C.; Correia, J.D.G.; Mendes, F.; Quiroga, A.G.. "Novel structures of platinum complexes bearing N-bisphosphonates and study of their biological properties". Journal of Inorganic Biochemistry 191 (2019): 112-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057163055&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2018.11.010 Joana Guerreiro; Vítor Alves; Antero Abrunhosa; António Paulo; Octávia Gil; Filipa Mendes. "Radiobiological Characterization of 64CuCl2 as a Simple Tool for Prostate Cancer Theranostics". Molecules (2018): https://doi.org/10.3390/molecules23112944. 10.3390/molecules23112944 Vera F. C. Ferreira; Bruno L. Oliveira; João D. Santos; João D. G. Correia; Carlos M. Farinha; Filipa Mendes. "Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe". ChemMedChem 13 14 (2018): 1469-1478. https://doi.org/10.1002/cmdc.201800187. 10.1002/cmdc.201800187 Palma, E.; Botelho, H.M.; Morais, G.R.; Rodrigues, I.; Santos, I.C.; Campello, M.P.C.; Raposinho, P.; et al. "Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies". Journal of Biological Inorganic Chemistry (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85057336330&partnerID=MN8TOARS. 10.1007/s00775-018-1629-6 Francisco Navas; Filipa Mendes; Isabel Santos; Carmen Navarro-Ranninger; Silvia Cabrera; Adoración G. Quiroga. "Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands". Inorganic Chemistry 56 11 (2017): 6175-6183. https://doi.org/10.1021/acs.inorgchem.7b00136. 10.1021/acs.inorgchem.7b00136 Maria Angeles Medrano; Maurício Morais; Vera F. C. Ferreira; João D. G. Correia; António Paulo; Isabel Santos; Carmen Navarro-Ranninger; et al. "Nonconventional trans -Platinum Complexes Functionalized with RDG Peptides: Chemical and Cytototoxicity Studies". European Journal of Inorganic Chemistry 2017 12 (2017): 1835-1840. https://doi.org/10.1002%2Fejic.201700072. 10.1002/ejic.201700072 Palma, E.; Mendes, F.; Morais, G.R.; Rodrigues, I.; Santos, I.C.; Campello, M.P.C.; Raposinho, P.; et al. "Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes". Journal of Inorganic Biochemistry 167 (2017): 68-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006054906&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2016.11.026 Scalese, G.; Correia, I.; Benítez, J.; Rostán, S.; Marques, F.; Mendes, F.; Matos, A.P.; Costa Pessoa, J.; Gambino, D.. "Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands". Journal of Inorganic Biochemistry 166 (2017): 162-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995555569&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2016.11.010 Pereira, E.; Do Quental, L.; Palma, E.; Oliveira, M.C.; Mendes, F.; Raposinho, P.; Correia, I.; et al. "Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85012284343&partnerID=MN8TOARS. 10.1038/srep42544 Quental, L.; Raposinho, P.; Mendes, F.; Santos, I.; Navarro-Ranninger, C.; Alvarez-Valdes, A.; Huang, H.; et al. "Combining imaging and anticancer properties with new heterobimetallic Pt(II)/M(i) (M = Re,^99mTc) complexes". Dalton Transactions 46 42 (2017): 14523-14536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85024380558&partnerID=MN8TOARS. 10.1039/c7dt00043j Vultos, F.; Fernandes, C.; Mendes, F.; Marques, F.; Correia, J.D.G.; Santos, I.; Gano, L.. "A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells". ChemMedChem 12 14 (2017): 1103-1107. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021713335&partnerID=MN8TOARS. 10.1002/cmdc.201700287 Morais, M.; Ferreira, V.F.C.; Figueira, F.; Mendes, F.; Raposinho, P.; Santos, I.; Oliveira, B.L.; et al. "Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters". Dalton Transactions 46 42 (2017): 14537-14547. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032622926&partnerID=MN8TOARS. 10.1039/c7dt01146f Sofia Gama; Inês Rodrigues; Filipa Mendes; Isabel C. Santos; Elisabetta Gabano; Beata Klejevskaja; Jorge Gonzalez-Garcia; et al. "Anthracene-terpyridine metal complexes as new G-quadruplex DNA binders". Journal of Inorganic Biochemistry 160 (2016): 275-286. https://doi.org/10.1016%2Fj.jinorgbio.2016.04.002. 10.1016/j.jinorgbio.2016.04.002 Leite, S.M.G.; Lima, L.M.P.; Gama, S.; Mendes, F.; Orio, M.; Bento, I.; Paulo, A.; Delgado, R.; Iranzo, O.. "Copper(II) complexes of phenanthroline and histidine containing ligands: Synthesis, characterization and evaluation of their DNA cleavage and cytotoxic activity". Inorganic Chemistry 55 22 (2016): 11801-11814. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998678731&partnerID=MN8TOARS. 10.1021/acs.inorgchem.6b01884 Kydonaki, T.E.; Tsoukas, E.; Mendes, F.; Hatzidimitriou, A.G.; Paulo, A.; Papadopoulou, L.C.; Papagiannopoulou, D.; Psomas, G.. "Synthesis, characterization and biological evaluation of ^99mTc/Re-tricarbonyl quinolone complexes". Journal of Inorganic Biochemistry 160 (2016): 94-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84970002369&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2015.12.010 Oliveira, B.L.; Morais, M.; Mendes, F.; Moreira, I.S.; Cordeiro, C.; Fernandes, P.A.; Ramos, M.J.; et al. "Re(I) and Tc(I) Complexes for Targeting Nitric Oxide Synthase: Influence of the Chelator in the Affinity for the Enzyme". Chemical Biology and Drug Design 86 5 (2015): 1072-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944163069&partnerID=MN8TOARS. 10.1111/cbdd.12575 Fernandes, T.A.; Mendes, F.; Roseiro, A.P.S.; Santos, I.; Carvalho, M.F.N.N.. "Insight into the cytotoxicity of polynuclear Cu(I) camphor complexes". Polyhedron 87 (2015): 215-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-84916897699&partnerID=MN8TOARS. 10.1016/j.poly.2014.11.020 Gabano, E.; Gama, S.; Mendes, F.; Fregonese, F.; Paulo, A.; Ravera, M.. "Application of microwave-assisted heating to the synthesis of Pt(II) complexes". Inorganica Chimica Acta 437 (2015): 16-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939800779&partnerID=MN8TOARS. 10.1016/j.ica.2015.07.042 Nunes, P.; Morais, G.R.; Palma, E.; Silva, F.; Oliveira, M.C.; Ferreira, V.F.C.; Mendes, F.; et al. "Isostructural Re(i)/<sup>99m</sup>Tc(i) tricarbonyl complexes for cancer theranostics". Organic and Biomolecular Chemistry 13 18 (2015): 5182-5194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928905685&partnerID=MN8TOARS. 10.1039/c5ob00124b Côrte-Real, L.; Mendes, F.; Coimbra, J.; Morais, T.S.; Tomaz, A.I.; Valente, A.; Garcia, M.H.; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". Journal of Biological Inorganic Chemistry 19 6 (2014): 853-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905864221&partnerID=MN8TOARS. 10.1007/s00775-014-1120-y Adriaenssens, L.; Liu, Q.; Chaux-Picquet, F.; Tasan, S.; Picquet, M.; Denat, F.; Le Gendre, P.; et al. "Novel heterobimetallic radiotheranostic: Preparation, activity, and biodistribution". ChemMedChem 9 7 (2014): 1567-1573. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903819569&partnerID=MN8TOARS. 10.1002/cmdc.201300494 Santos, I.; Gama, S.; Rodrigues, I.; Marques, F.; Palma, E.; Correia, I.; Carvalho, M.F.N.N.; et al. "New ternary bipyridine-terpyridine copper(ii) complexes as self-activating chemical nucleases". RSC Advances 4 106 (2014): 61363-61377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912051462&partnerID=MN8TOARS. 10.1039/c4ra12085j Herrera, J.M.; Mendes, F.; Gama, S.; Santos, I.; Navarro Ranninger, C.; Cabrera, S.; Quiroga, A.G.. "Design and biological evaluation of new platinum(II) complexes bearing ligands with DNA-targeting ability". Inorganic Chemistry 53 23 (2014): 12627-12634. http://www.scopus.com/inward/record.url?eid=2-s2.0-84914141357&partnerID=MN8TOARS. 10.1021/ic502373n Moura, C.; Mendes, F.; Gano, L.; Santos, I.; Paulo, A.. "Mono- and dicationic Re(I)/99mTc(I) tricarbonyl complexes for the targeting of energized mitochondria". Journal of Inorganic Biochemistry 123 (2013): 34-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874931259&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2013.02.008 Gabano, E.; Gama, S.; Mendes, F.; Gariboldi, M.B.; Monti, E.; Bombard, S.; Bianco, S.; Ravera, M.. "Study of the synthesis, antiproliferative properties, and interaction with DNA and polynucleotides of cisplatin-like Pt(II) complexes containing carcinogenic polyaromatic amines". Journal of Biological Inorganic Chemistry 18 7 (2013): 791-801. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885598920&partnerID=MN8TOARS. 10.1007/s00775-013-1022-4 Moura, C.; Gano, L.; Mendes, F.; Raposinho, P.D.; Abrantes, A.M.; Botelho, M.F.; Santos, I.; Paulo, A.. "99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation". European Journal of Medicinal Chemistry 50 (2012): 350-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858449323&partnerID=MN8TOARS. 10.1016/j.ejmech.2012.02.014 Gama, S.; Mendes, F.; Esteves, T.; Marques, F.; Matos, A.; Rino, J.; Coimbra, J.; et al. "Synthesis and Biological Studies of Pyrazolyl-Diamine Pt^II Complexes Containing Polyaromatic DNA-Binding Groups". ChemBioChem 13 16 (2012): 2352-2362. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868093608&partnerID=MN8TOARS. 10.1002/cbic.201200472 Tomaz, A.I.; Jakusch, T.; Morais, T.S.; Marques, F.; De Almeida, R.F.M.; Mendes, F.; Enyedy, É.A.; et al. "[Ru^II(¿⁵-C5H5 (bipy)(PPh3)]⁺, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin". Journal of Inorganic Biochemistry 117 (2012): 261-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869080345&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2012.06.016 Mendes, F.; Farinha, C.M.; Felício, V.; Alves, P.C.; Vieira, I.; Amaral, M.D.. "BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner". Cellular Physiology and Biochemistry 30 5 (2012): 1120-1133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869203984&partnerID=MN8TOARS. 10.1159/000343303 Serratrice, M.; Edafe, F.; Mendes, F.; Scopelliti, R.; Zakeeruddin, S.M.; Grätzel, M.; Santos, I.; Cinellu, M.A.; Casini, A.. "Cytotoxic gold compounds: Synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1". Dalton Transactions 41 11 (2012): 3287-3293. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857563583&partnerID=MN8TOARS. 10.1039/c2dt11913g Li, H.; Yang, W.; Mendes, F.; Amaral, M.D.; Sheppard, D.N.. "Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth". American Journal of Physiology - Renal Physiology 303 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867719641&partnerID=MN8TOARS. 10.1152/ajprenal.00130.2012 Neto, C.; Fernandes, C.; Oliveira, M.C.; Gano, L.; Mendes, F.; Kniess, T.; Santos, I.. "Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents". Nuclear Medicine and Biology 39 2 (2012): 247-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856346831&partnerID=MN8TOARS. 10.1016/j.nucmedbio.2011.09.001 Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent". Nuclear Medicine and Biology 39 2 (2012): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856362049&partnerID=MN8TOARS. 10.1016/j.nucmedbio.2011.08.007 Can, D.; Spingler, B.; Schmutz, P.; Mendes, F.; Raposinho, P.; Fernandes, C.; Carta, F.; et al. "(M=Re or 99mTc) arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX". Angewandte Chemie - International Edition 51 14 (2012): 3354-3357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859226949&partnerID=MN8TOARS. 10.1002/anie.201107333 Gama, S.; Santos, I.; Mendes, F.; Marques, F.; Santos, I.C.; Carvalho, M.F.; Correia, I.; Pessoa, J.C.; Paulo, A.. "Copper(II) complexes with tridentate pyrazole-based ligands: Synthesis, characterization, DNA cleavage activity and cytotoxicity". Journal of Inorganic Biochemistry 105 5 (2011): 637-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066808&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2011.01.013 Mendes, F.; Groessl, M.; Nazarov, A.A.; Tsybin, Y.O.; Sava, G.; Santos, I.; Dyson, P.J.; Casini, A.. "Metal-based inhibition of poly(ADP-ribose) polymerase-the guardian angel of DNA". Journal of Medicinal Chemistry 54 7 (2011): 2196-2206. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953796119&partnerID=MN8TOARS. 10.1021/jm2000135 Mendes, F.; Paulo, A.; Santos, I.. "Metalloprobes for functional monitoring of tumour multidrug resistance by nuclear imaging". Dalton Transactions 40 20 (2011): 5377-5393. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955600298&partnerID=MN8TOARS. 10.1039/c0dt01275k Francisco, C.; Gama, S.; Mendes, F.; Marques, F.; Cordeiro Dos Santos, I.; Paulo, A.; Santos, I.; et al. "Pt(ii) complexes with bidentate and tridentate pyrazolyl-containing chelators: Synthesis, structural characterization and biological studies". Dalton Transactions 40 21 (2011): 5781-5792. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957530790&partnerID=MN8TOARS. 10.1039/c0dt01785j Oliveira, B.L.; Raposinho, P.D.; Mendes, F.; Santos, I.C.; Santoes, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.; Correia, J.D.G.. "Targeting nitric oxide synthase with 99mTc/Re-tricarbonyl complexes containing pendant guanidino or isothiourea moieties". Journal of Organometallic Chemistry 696 5 (2011): 1057-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952194212&partnerID=MN8TOARS. 10.1016/j.jorganchem.2010.09.019 Oliveira, B.L.; Raposinho, P.D.; Mendes, F.; Figueira, F.; Santos, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.; Correia, J.D.G.. "Re and Tc tricarbonyl complexes: From the suppression of NO biosynthesis in macrophages to in vivo targeting of inducible nitric oxide synthase". Bioconjugate Chemistry 21 12 (2010): 2168-2172. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650341241&partnerID=MN8TOARS. 10.1021/bc100291e Esteves, T.; Xavier, C.; Gama, S.; Mendes, F.; Raposinho, P.D.; Marques, F.; Paulo, A.; et al. "Tricarbonyl M(I) (M = Re, 99mTc) complexes bearing acridine fluorophores: Synthesis, characterization, DNA interaction studies and nuclear targeting". Organic and Biomolecular Chemistry 8 18 (2010): 4104-4116. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955948795&partnerID=MN8TOARS. 10.1039/c0ob00073f Ramalho, A.S.; Lewandowska, M.A.; Farinha, C.M.; Mendes, F.; Gonçalves, J.; Barreto, C.; Harris, A.; Amaral, M.D.. "Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients". Cellular Physiology and Biochemistry 24 5-6 (2009): 335-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450231758&partnerID=MN8TOARS. 10.1159/000257426 Schmidt, A.; Hughes, L.K.; Cai, Z.; Mendes, F.; Li, H.; Sheppard, D.N.; Amaral, M.D.. "Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator". British Journal of Pharmacology 153 6 (2008): 1311-1323. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349033879&partnerID=MN8TOARS. 10.1038/sj.bjp.0707663 Mendes, F.; Wakefield, J.; Bachhuber, T.; Barroso, M.; Bebok, Z.; Penque, D.; Kunzelmann, K.; Amaral, M.D.. "Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies". Cellular Physiology and Biochemistry 16 4-6 (2005): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-27844525431&partnerID=MN8TOARS. 10.1159/000089857 Mendes, F.; Farinha, C.M.; Roxo-Rosa, M.; Fanen, P.; Edelman, A.; Dormer, R.; McPherson, M.; et al. "Antibodies for CFTR studies". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 69-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944369736&partnerID=MN8TOARS. 10.1016/j.jcf.2004.05.016 Harris, C.M.; Mendes, F.; Dragomir, A.; Doull, I.J.M.; Carvalho-Oliveira, I.; Bebok, Z.; Clancy, J.P.; et al. "Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 43-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944385576&partnerID=MN8TOARS. 10.1016/j.jcf.2004.05.009 Mendes, F.; Doucet, L.; Hinzpeter, A.; Féree, C.; Lipecka, J.; Fritsch, J.; Edelman, A.; et al. "Immunohistochemistry of CFTR in native tissues and primary epithelial cell cultures". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 37-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944422399&partnerID=MN8TOARS. 10.1016/j.jcf.2004.05.008 Farinha, C.M.; Mendes, F.; Roxo-Rosa, M.; Penque, D.; Amaral, M.D.. "A comparison of 14 antibodies for the biochemical detection of the cystic fibrosis transmembrane conductance regulator protein". Molecular and Cellular Probes 18 4 (2004): 235-242. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242674336&partnerID=MN8TOARS. 10.1016/j.mcp.2004.03.005 Mendes, F.; Rosa, M.R.; Dragomir, A.; Farinha, C.M.; Roomans, G.M.; Amaral, M.D.; Penque, D.. "Unusually common cystic fibrosis mutation in Portugal encodes a misprocessed protein". Biochemical and Biophysical Research Communications 311 3 (2003): 665-671. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242577536&partnerID=MN8TOARS. 10.1016/j.bbrc.2003.10.048 Doucet, L.; Mendes, F.; Montier, T.; Delépine, P.; Penque, D.; Férec, C.; Amaral, M.D.. "Applicability of different antibodies for the immunohistochemical localization of CFTR in respiratory and intestinal tissues of human and murine origin". Journal of Histochemistry and Cytochemistry 51 9 (2003): 1191-1199. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041819843&partnerID=MN8TOARS. Farinha, C.M.; Nogueira, P.; Mendes, F.; Penque, D.; Amaral, M.D.. "The human Dnaj homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70". Biochemical Journal 366 3 (2002): 797-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037106481&partnerID=MN8TOARS. 10.1042/BJ20011717 Zaman, K.; McPherson, M.; Vaughan, J.; Hunt, J.; Mendes, F.; Gaston, B.; Palmer, L.A.. "S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation". Biochemical and Biophysical Research Communications 284 1 (2001): 65-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034804969&partnerID=MN8TOARS. 10.1006/bbrc.2001.4935 Penque, D.; Mendes, F.; Beck, S.; Farinha, C.; Pacheco, P.; Nogueira, P.; Lavinha, J.; Malhó, R.; Amaral, M.D.. "Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells". Laboratory Investigation 80 6 (2000): 857-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033918281&partnerID=MN8TOARS.
Capítulo de livro	Pinto, Catarina I. G.; Guerreiro JF; Francisco Silva; Mendes, Filipa; Paulo, António. Autor correspondente: Paulo, António. "Radiopharmaceuticals for Molecular Imaging and Theranostics of Glioblastoma". In New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics. Elsevier, 2022. No prelo Matos, M; Mendes, Filipa; Valente, A.; Morais, T.S.; Zinck, P; Garcia, MH; Bicho, M.; Marques, F. "Ruthenium-based anticancer compounds: insights into their cellular targeting and mechanism of action". In Ruthenium Complexes - Photochemical and Biomedical Applications, editado por Alvin A. Holder; Jimmie L. Bullock; Welsey R. Browne; Mark A. LAwrence; Lothar Lilge. Wiley-VCH Verlag, 2017.
Resumo em conferência	Ferreira, VFC; Guerreiro JF; Correia JG; Gonçalves J; Farinha CM; Mendes F. Autor correspondente: Mendes F. "Development of molecular imaging tools to monitor drug efficacy through assessment of CFTR localization in vivo". Trabalho apresentado em North American Cystic Fibrosis Conference, 2021. Publicado Gano, Maria Lurdes; Vultos, F.; Fernandes, Célia; Mendes, Filipa; Correia, JDG. "Biological evaluation of radiolabelled peptides for oestrogen positive tumour theranostics". Trabalho apresentado em Annual Congress of the European Association of Nuclear Medicine October, Barcelona, 2019. Publicado Mendes, Filipa; Oliveira, Bruno L.; Morais, Mauricio; Raposinho, P.D.; Correia, JDG. "Radiometallated L-arginine derivatives for imaging nitric oxide synthase in vivo". Trabalho apresentado em 33rd European Peptide Symposium, Sofia, 2014. Publicado Ferreira, VFC; Oliveira, BL; Correia, JDG; Santos, I.; Farinha, CMF; Mendes, Filipa. "Cystic Fibrosis: new molecular imaging tools". Trabalho apresentado em 12th European Biological Inorganic Chemistry Conference, Zurich, 2014. Publicado Paulo, A.; Rodrigues, I.; Campello, M.P.C.; Morais, G.; Ferreira, VFC; Mendes, Filipa; Santos, I.; Gama, S.. "DNA Binding and Cytotoxic Activity of Zn(II) and Cu(II) Complexes with New Bis(thiosemicarbazone) Derivatives". Trabalho apresentado em 12th European Biological Inorganic Chemistry Conference, Zurich, 2014. Publicado Rodrigues, I.; Mendes, Filipa; Palma, E.; Correia, I.; Carvalho, MF; Cordeiro Dos Santos, I.; Marques, F.; et al. "New Mixed-Ligand Cu(II) Complexes Acting as “Self-activating” Chemical Nucleases". Trabalho apresentado em 12th European Biological Inorganic Chemistry Conference, Zurich, 2014. Publicado Neto, C.; Oliveira, MC; Fernandes, C.; Gano, Lurdes; Mendes, Filipa; Kniess, T.; Santos, I.. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". Trabalho apresentado em 19th International Symposium on Radiopharmaceutical Sciences, 2011. Publicado Mendes, Filipa; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Evaluation of 99mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance". Trabalho apresentado em Annual Congress of the EANM, Vienna, 2010. Publicado Gano, Lurdes; Mendes, Filipa; Fernandes, C.; Paulo, António; Santos, I.. "Biological Evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection". Trabalho apresentado em 15th European Symposium on Radiopharmacy and Radiopharmaceuticals, Edinburgh, 2010. Publicado Li, H.; Yang, W.; Mendes, Filipa; Amaral, MD; Sheppard, DN. "Renal cyst formation as tool for CFTR research". Trabalho apresentado em 31st European Cystic Fibrosis Conference, 2008. Publicado • 10.2118/4789-ms Dahimène S; Luz, S.; Mendes, Filipa; Almaça, J.; Barro-Soria, R.; Kunzelmann, K.; Amaral, MD. "Novel cellular models to identify rescuing of F508del-CFTR trafficking defect". Trabalho apresentado em 22nd Annual North American Cystic Fibrosis Conference, 2008. Publicado Mendes, Filipa; Vieira, I.; Alves, PC; Farinha, CMF; Amaral, MD. "Role of Bag-1 on the turnover and processing of wild-type and F508del-CFTR". Trabalho apresentado em 20th Annual North American Cystic Fibrosis Conference, Denver, 2006. Publicado Farinha, CMF; Mendes, Filipa; Roxo-Rosa, M.; Amaral, MD. "Low Temperature Studies Suggest Conformational Differences Between Wild-Type and F508del-CFTR". Trabalho apresentado em 20th Annual North American Cystic Fibrosis Conference, Denver, 2006. Publicado Ramalho, AS; Farinha, CMF; Mendes, Filipa; Neto, M.; Amaral, MD. "Lack of N-terminus causes major impairment on CFTR processing but does not abolish function". Trabalho apresentado em 19th Annual North American Cystic Fibrosis Conference, Baltimore, 2005. Publicado Mendes, Filipa; Wakefield, J.; Amaral, MD; Bebok, Z.; Penque, D.. "Characterization of a New Polarized Epithelial Cell Model to Study CFTR". Trabalho apresentado em 18th Annual North American Cystic Fibrosis Conference, Saint Louis, 2004. Publicado Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Effect of R555K or G550E traffic restoring substitutions upon A561E-CFTR processing". Trabalho apresentado em 25th Congress ECFS, 2002. Publicado Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Misprocessing of A561E-CFTR is partially corrected by R555K or G550E traffic Restoring Substitutions". Trabalho apresentado em 15th Annual North American Cystic Fibrosis Conference, Orlando, 2001. Publicado Mendes, Filipa; Penque, D.; Barroso, M.. "A Polarized Epithelial Cell Model to Study the Membrane Traffic of the Cystic Fibrosis Transmembrane Conductance Regulator". Trabalho apresentado em 2001 Annual ASCB Meeting, Washington, 2001. Publicado

Propriedade Intelectual

Patente

Garcia, MH; Morais, T.S.; Tomaz AI; Marques F; Mendes, Filipa. 2013. "Transition metal complexes for pharmaceutical applications".
Concedida/Emitida
Amaral, MD; Dahimène S; Mendes, Filipa. 2011. "Two novel human epithelial cell lines to be used in assays for traffic studies/ screens of CFTR protein (wild-type and with the F508del mutation". Portugal.
Pendente

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2021/09	Health and Environment Research Areas at C2TN	First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies)
2019/09/12	Assessment of CFTR localization in vivo to monitor efficacy of CFTR correctors	Invited Talk - REAP Expert Meeeting European Cystic Fibrosis Society (ECFS) (Lisboa, Portugal)
2019/09	New insights on the radiobiological effects of 64CuCl2 - a simple tool for prostate cancer theranostics	I NOVA Biophysica Internacional Conference (Lisboa, Portugal)
2019/03	Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe	16th European Cystic Fibrosis Basic Science Conference European Cystic Fibrosis Society (Dubrovnik, Croácia)
2018/06	Molecular and Cell Biology methods for validation of (imaging) biomarkers	Summer School “Development and Pre-clinical Evaluation of Radiopharmaceuticals” Marie Curie Innovative Training Network "MEDICIS-Promed" (Cascais, Portugal)
2017/11	Ionizing radiation and health: Imaging and exposure biomarkers	Physics Department seminars Physics Departmentm, IST (Lisboa, Portugal)
2014/08	Molecular Imaging probes for in vivo detection of the Cystic Fibrosis Protein	2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules COST Action CM1105 (Zurich, Suiça)
2014/05	Biological relevance and general applications of peptides	Training School “Peptides for Targeted Drug Delivery" COST Action CM1105“Functional metal complexes that bind to biomolecules” (Bobadela LRS, Portugal)
2014/04	Biomarkers for the Theranostic Strategy - Cancer and Molecular Theranostics	Expert meeting COST action CM1105 (Bobadela LRS, Portugal)
2013/10	New Platinum (II) complexes with DNA-targeting ability	1st Meeting on Functional metal complexes that bind to biomolecules COST ACTION CM1105 (Barcelona, Espanha)
2013/09	Perfusion and specific radioprobes for cardiac imaging	Cardiotecnhix International Congress on Cardiovascular Technologies Cardiotecnhix (Vilamoura, Portugal)
2012/12	Imaging in the era of molecular oncology: new probes for detection of multidrug resistance	Bioengineering Department Seminars IST (Lisboa, Portugal)
2012/12	Sondas para Imagiologia Cardiovascular	Workshop “Biomarcadores sanguíneos e imagiologia da placa aterosclerótica” Instituto Superior Técnico (Sacavém, Portugal)
2012/10	From cardiology to oncology: new radioactive probes for detection of cancer multidrug resistance	Chem Forum -Autumn Edition IST (Lisboa, Portugal)
2008/12	Pharmacogenomics – contribute for cancer therapeutics	Symposium Cancer and Therapeutic Approaches Universidade Lusófona de Humanidades e Tecnologias (Lisboa, Portugal)
2007	An approach to chaperone therapy: correcting the basic defect in Cystic Fibrosis	V International Symposium Sociedade Portuguesa de Doenças Metabólicas Sociedade Portuguesa de Doenças Metabólicas (Porto, Portugal)
2007	Role of Bag-1 in turnover and processing of wild-type and F508del-CFTR	Workshop Proteins in Health and Disease: from structure to function Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2006	Modulation of CFTR biosynthesis and maturation by molecular chaperones: implications for Cystic Fibrosis	Dia do Jovem Investigador do Instituto Ricardo Jorge Instituto Ricardo Jorge (Lisboa, Portugal)
2004	Characterization of a New Polarized Epithelial Cell Model to Study the Cystic Fibrosis Transmembrane Conductance Regulator	New Frontiers in the Basic Science of Cystic Fibrosis European Cystic Fibrosis Society (Tomar, Portugal)
1999	Imunolocalização da proteína F508del-CFTR na região apical de células epiteliais nasais	XXXIV Reun Ann Soc Port Mic Electr e Biol Cel Sociedade Portuguesa de Microscopia Electrónica e Biologia Celular (Lisboa, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2021/02 - Atual	Targeting of cationic amino acid transporters with radiometallated amino acids for cancer theranostics Coorientador	Chemistry (Doutoramento) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021/02 - Atual	Biological evaluation of copper-64 chloride as a promising tool for cancer theranostics Orientador	Biomedical Engineering (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02 - Atual	Modeling radiobiological effects of nanoparticles in proton therapy of glioblastomas Coorientador	Biomedical and Biophysics Engineering (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/02 - Atual	Quantification of biological effects induced by low doses of X-rays in non-tumoral breast cells Coorientador de Ana Filipa Inácio	Radiation Protection and Safety (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/07	Novel antibody fragments - selection and validation as Cystic Fibrosis imaging tools Orientador	Microbiology (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/06	Avaliação pré-clínica de novas terapias anti-tumorais em modelos celulares 3D de cancro da mama Orientador	Bioengineering: Regenerative and Precision Medicine (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/03 - 2022/11	Antibody Conjugates for Combined Anticancer Radio- and Chemotherapy Coorientador	MSc Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/04 - 2021/12	Postdoctoral Fellow recruited by the grant "A Molecular Imaging Approach to Cystic Fibrosis" Orientador de Joana Guerreiro	Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09/01 - 2021/04	Master Fellowship in UTAustin TOF-PET project Orientador	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2016/02 - 2020/10/08	New Molecular Imaging tools for Cystic Fibrosis Orientador de Vera Filipa Ferreira	Biotechnology and Biosciences (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/02 - 2019/10	Development of 3D spheroid cultures of cancer cells for the preclinical evaluation of a novel theranostic agents Orientador de Catarina Isabel Pinto	Biomedical Engeneering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/01 - 2018/10	Cystic Fibrosis: novel molecular imaging tools Orientador de Mariana Anderson Morais David	Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/09 - 2015	Research Fellow Vera Ferreira, MSc in the framework of the projects EXPL/BIM-MEC/0115/2012 (Set2013-Set2014) and ProQr Therapeutics (Aug –Dec 2015) Orientador	Centro de Ciências e Tecnologias Nucleares, Portugal
2013/09 - 2013/12	Medicina Nuclear Convencional e o seu contributo diagnóstico no Carcinoma da Próstata localizado e metastizado Orientador de Inês Matreno	Monography - Nuclear Medicine (Outra) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/11 - 2013/09	Biological Evaluation of cationic 99mTc(I) complexes as probes for tumoral detection and functional monitoring of multidrug resistance Orientador de Fernando Toscano	Biomedical Inorganic Chemistry - applications in diagnostic and therapy (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2013/07	A Molecular Imaging approach to Cystic Fibrosis Orientador de Vera Filipa Ferreira	Biochemistry (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2012/12	99mTc(I) tricarbonyl complexes for mitochondria targeting Orientador de Ana Bárbara Pereira	Undergraduate research project in Nuclear Medicine (Iniciação científica) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/01 - 2012/07	In vitro evaluation of 99mTc(I) complexes as probes for tumoral detection: influence of the plasma membrane and mitochondrial membrane potential on the cell uptake Orientador de Teresa Pinto	Undergraduate research project - Nuclear Medicine (Iniciação científica) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011/09 - 2011/12	Utilização de radiofármacos de 99mTc para monitorização funcional de resistência a múltiplos fármacos Orientador de Teresa Pinto	Undergraduate research project - Nuclear Medicine (Iniciação científica) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2006/09 - 2007/07	Intracellular trafficking of CFTR in polarized cells Coorientador de Simão Filipe Luz	Biochemistry (Licenciatura/Bacharelato) Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2021/07 - Atual	Chair of the Organizing Committee of the Workshop 2021 Thematic Strand Radiopharmaceutical Sciences and Health Physics (2021) Oficina (workshop) (Presidente da Comissão Organizadora)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021 - Atual	Member of the Organizing Committee “First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies), online, September 2021 (2021) Oficina (workshop) (Membro da Comissão Organizadora)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2019/11 - 2019/11	Member of the Organizing Committee of the “Workshop 2019 Thematic Strand Radiopharmaceutical Sciences and Health Physics” (2019/11 - 2019/11) Oficina (workshop) (Membro da Comissão Organizadora)	Centro de Ciências e Tecnologias Nucleares, Portugal
2017/12 - 2017/12	Member of the Organizing Committee of the “1St C2TN workshop- radiation for science and society” (2017/12 - 2017/12) Oficina (workshop) (Membro da Comissão Organizadora)	Centro de Ciências e Tecnologias Nucleares, Portugal
2015/11 - 2015/11	Member of the Organizing Committee of the ““Imaging and Radiation Biomarkers Workshop” organized by the IST at C2TN, Universidade de Lisboa, November 2015. (2015/11 - 2015/11) Oficina (workshop) (Membro da Comissão Organizadora)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2004 - 2008	Member of the Organizing Committee of the “European Cystic Fibrosis Society Conference - New Frontiers in the Basic Science of Cystic Fibrosis” – 5 editions in Portugal: 2004 in Tomar, 2005 in Évora, 2006 in Carvoeiro, 2007 in Tavira and 2008 in Régua. (2004 - 2008) Conferência (Membro da Comissão Organizadora)	European Cystic Fibrosis Society, Dinamarca
2007/07 - 2007/07	Member of the Organizing Committee of the “Workshop on Epithelial Biology: Epithelial cells & tissues: production, cultivation and characterization”, organized by the EuroCareCF - (EU) (2007/07 - 2007/07) Oficina (workshop) (Membro da Comissão Organizadora)	Universidade de Lisboa Faculdade de Ciências, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
1999 - Atual	Participation in International and National Scientific Conferences from Cell Biology, Cystic Fibrosis, Medicinal/Bioinorganic Chemistry, Molecular Imaging and Radiopharmaceutical fields - 93 posters in international meetings and 18 in portuguese conferences. Congresso
2018/04 - 2018/04	Invited panelist at the “New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications” Organized by IST and IAEA (International atomic energy agency) Mesa-redonda	New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications Universidade de Lisboa Instituto Superior Técnico, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2022/09	Susceptibilidade dos individuos portadores de mutacoes BRCA1 e BRCA 2 a radiacao de diagnostico Arguente principal	Diana Pereira Goncalves (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/11	RA-223 no tratamento do carcinoma da próstata metastático Arguente principal	Carolina Alves Silva (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/03/30	Regulation of the TGF-ß1 signaling in cystic fibrosis: the role of LMTK2 Arguente	Daniel Filipe Soares Pereira da Cruz (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/05	Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks Arguente principal	Claúdia Almeida Pires Loureiro (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09	Search for new modulators of Phe508del-CFTR retention at the plasma membrane of epithelial cells Arguente principal	Ana Margarida Fernandes Pereira de Matos (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal
2017/10	Characterization of CFTR orphan mutations Arguente principal	Sofia Santos Ramalho (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2015/10	Desenvolvimento de um biossensor molecular para o estudo translacional da Fibrose Quística e outras doenças respiratórias Arguente principal	Angela Dias Alves (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2015/05	Estudio y dieseño de complejos antitumorales de Pt(II) y Pt(IV), usando nuevas estrategias para conseguir una mayor actividad y especificidade Vogal	Medrano MA (Doutoramento) Fundación de la Universidad Autónoma de Madrid, Espanha
2012/10	Complexos de Ruténio como potenciais agentes terapêuticos: estudos dos mecanismos de captação celular e modulação de enzimas metabólicos Arguente principal	Leonor Corte-Real (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/02	Tc(I)/Re(I) Organometallic for Molecular Imaging of Neoplasic Tissues Arguente	Carolina Moura (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal
2011/12	Recruitment of Pyk2 during complement mediated phagocytosis and expression of kinase domains in insect cell Arguente principal	Carina Santos (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2008/06	Characterization of the impact of a novel antimicrobial photosensitizer Arguente principal	Sónia Alexandra Gonçalves Mendes (Mestrado) Universidade Católica Portuguesa, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2015 - 2015	LOWDOSE-PT-2015 - Biological effects and risks of low dose and protracted exposures to ionizing radiation	Instituto Superior Técnico

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022 - Atual	Frontiers in Molecular Biosciences - special topic editor	Frontiers
2021 - Atual	Molecules - special issue editor	MDPI
2021 - Atual	Fontiers in Medicine -Nuclear Medicine - review editor	Frontiers

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2017 - Atual	Reviewer for the European Science Foundation - expert panel Life and Health Sciences Avaliador	European Science Foundation, França	Fonds Wetenschappelijk Onderzoek Vlaanderen Université de Bordeaux Università degli Studi di Torino AXA SA

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2013 - Atual	Genetic Engeneering	Engenharia Biomédica (Mestrado integrado)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - Atual	Molecular Biotechnology	Biotecnologia (Mestrado integrado)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2012	Pharmacogenomics	Ciências Farmacêuticas (Mestrado Intregado) (Mestrado integrado)	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2007/07 - 2007/07	Workshop on Epithelial Biology: “Epithelial cells & tissues: production, cultivation and characterization”, organized by the EurocareCF Coordination Action	(Outros)	Universidade de Lisboa Faculdade de Ciências, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2021/04/01 - Atual	American Society of Chemistry
2013 - Atual	Society of Biological Inorganic Chemistry
2010 - Atual	European Association of Nuclear Medicine
2004 - Atual	Cystic Fibrosis European Network
2001 - Atual	American Society of Cell Biology
1999 - Atual	Ordem dos Biólogos

Revisão ad hoc de artigos em revista

	Nome da revista (ISSN)	Editora
2022 - Atual	Cancers	MDPI
2022 - Atual	Biology	MDPI
2020 - Atual	Bioconjugate Chemistry	ACS
2020 - Atual	Molecules	MDPI
2019 - Atual	JBIC Journal of Biological Inorganic Chemistry (1432-1327)	Springer-Verlag
2019 - Atual	Coordination Chemistry Reviews (0010-8545)	Elsevier
2019 - Atual	ChemistrySelect	Wiley-VCH Verlag

Distinções

Prémio

2006	Medal for Women in Science-Portugal - Medalha L'oreal para as Mulheres na Ciência L'oreal
2005	Gulbenkian Award for Research Incentive - Programa Gulbenkian de Estímulo à Investigação

Outra distinção

2020	Diploma for Excellence in Education (Diploma de Excelência no Ensino)
2019	Diploma for Excellence in Education (Diploma de Excelência no Ensino) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Diploma for Excellence in Education (Diploma de Excelência no Ensino) Universidade de Lisboa Instituto Superior Técnico, Portugal