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Filipa Fernandes Mendes is a Assistant Researcher (with tenure) at Universidade de Lisboa, Instituto Superior Técnico, Department of Nuclear Sciences and Engineering. Her scientific activity is developed at C2TN - Center for Nuclear Sciences and Technologies, where she is currently the Coordinator of the thematic strand "Radiopharmaceutical Sciences and Health Physics" and a member of the Coordinating Commission of the Scientific Council (CC-CC). Filipa Mendes is focused on merging advances in molecular biology with chemistry (radiopharmaceutical and medicinal) to advance molecular and biomedical imaging and therapy. Given her training and experience in molecular and cellular biology, present research interests are the understanding of the biological mechanisms and molecular interactions of radioactive compounds useful as probes for in vivo molecular imaging and/or targeted radiotherapy. She has extended the evaluation of cancer theranostic compounds (suitable for diagnosis and therapy) to 3D cellular models of cancer, and she is currently Editor of a Research Topic on the journal Frontiers in Molecular Biosciences on this subject. Moreover, she is interested in the development of novel molecular tools for the study of ABC transporters involved in human diseases, such as Cystic Fibrosis and Cancer Multidrug Resistance. She is the author of 68 articles in peer-reviewed journals (90% in Q1), 18 of which as senior author. She has over 1650 citations (H index 24 and i10 index 50) and was/is the PI of 3 FCT funded projects (including 1 Bilateral with France) and 1 industry research contract. Filipa Mendes has supervised 5 MSc and 1 PhD to completion and currently supervises/co-supervises 3 MSc and 3 PhD students. Since 2014 she teaches at the Department of Bioengineering, Instituto Superior Técnico, the courses Genetic Engineering and Molecular Biotechnology, and she has received several Excellence in Teaching diplomas.
Identification

Personal identification

Full name
Filipa Fernandes Mendes

Citation names

  • Mendes, Filipa

Author identifiers

Ciência ID
1711-EA6A-041A
ORCID iD
0000-0003-0646-1687
Researcher Id
B-2057-2010
Scopus Author Id
36465350400

Email addresses

  • fmendes@ctn.tecnico.ulisboa.pt (Professional)

Addresses

  • C2TN- Centro Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Professional)
  • DECN- Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Professional)

Websites

  • https://fenix.tecnico.ulisboa.pt/homepage/ist25493 (Scholar)
  • http://c2tn.tecnico.ulisboa.pt/index.php/r-d/research-groups/radiopharmaceutical-sciences/rs-home (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Beginner (A1) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2020/09/07 - 2020/09/18
Concluded
Gestão de equipas / Team management (Outros)
Companhia Própria - Formação e Consultoria, Portugal
na
2008 - 2008
Concluded
Edicção e Revisão de texto / Text Edition and Revision (Outros)
Universidade Católica Portuguesa, Portugal
2000 - 2004
Concluded
Biologia / Biology (Doutoramento)
Major in Biologia Celular / Cell Biology
Universidade de Lisboa Faculdade de Ciências, Portugal
"Expression, Localization and Traffic of Wild-Type and Mutant CFTR Protein" (THESIS/DISSERTATION)
PhD Summa cum laude (Aprovada com distinção e louvor)
1994 - 1999
Concluded
Biologia - Biologia Microbiana e Genética / Biology - Microbiology and Genetics (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Cystic fibrosis: Expression and Intracellular localization of CFTR protein" (THESIS/DISSERTATION)
18
Affiliation

Science

Category
Host institution
Employer
2016/01/01 - Current Auxiliary Researcher (Research) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Universidade de Lisboa Departamento de Engenharia e Ciências Nucleares, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2013/09/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/02/17 - 2014/06/30 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
2008/04/01 - 2012/05/01 Invited Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Positions / Appointments

Category
Host institution
Employer
2021/04 - Current Coordinator of the Health Thematic Line, C2TN Research Unit Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021/04 - Current Member of the Coordinating Council, C2TN Research Unit Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Others

Category
Host institution
Employer
2013/09/01 - 2015/12/31 Principal Investigator – “FCT Investigator” Development Grant (Life and Health Sciences) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2008/09/01 - 2013/08/31 Research Scientist - Ciência 2007 Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2005/01/01 - 2008/07/01 Post-doctoral Fellow Universidade de Lisboa Faculdade de Ciências, Portugal
2000/01/01 - 2004/12/31 PhD Student Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2001/05/01 - 2003/08/31 Visiting Graduate Student University of Virginia Department of Biology, United States
1998/09/01 - 1999/07/30 Undergraduate Trainee Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Projects

Contract

Designation Funders
2021 - Current Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer
PTDC/QUI-QIN/0146/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2020 - Current In-beam Time-of-Flight (TOF) Positron Emission Tomography (PET) for proton radiation therapy
LISBOA-01-0247-FEDER-045904
Researcher
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2024/03 A novel nanoplatform for melanoma targeting with hydroxyquinoline metal complexes
PTDC/QUI-QIN/0586/2020
Researcher
Ongoing
2022 - 2024 Targeted radiotherapy of radioresistant cancers – a radiobiological study with advanced cell models
2021.09137.CBM
Principal investigator
Ongoing
2021 - 2023/12/31 Organelle-targeted Radiocomplexes for Auger Therapy of Cancer
PTDC/MED-QUI/1554/2020
Co-Principal Investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022/07/31 Targeting the transporters of cationic amino acids for cancer radiotheranostics: experimental and computational chemistry approach
PTDC/QUI-NUC/30147/2017- FCT
Researcher
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022/07/31 Novel Molecular Imaging tools for Cystic Fibrosis
PTDC/BTM-TEC/29256/2017
Principal investigator
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015 - 2018 Validation of novel tools for detection of CFTR
CF antibodies
Principal investigator
Universidade de Lisboa Instituto Superior Técnico, Portugal
ProQR Therapeutics NV
Concluded
2013 - 2016/05 Molecular and Nano Tools for Cancer Theranostics
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2014 - 2015/03 Dual Targeting Strategy for EGFR Positive Tumors
Researcher
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2012 - 2015/02 Preclinical evaluation of ruthenium potential drugs for cancer therapy
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2015 Functional metal complexes that bind to biomolecules
COST Action CM1105
Researcher
Centro de Ciências e Tecnologias Nucleares, Portugal
Concluded
2012 - 2015 Nitric Oxide Synthase targeting with Re(I)/99mTc(I)-complexes containing L-Arg derivatives: A structure-activity study
PTDC/QUI-QUI/121752/2010
Researcher
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014/08 Targeting telomerase inhibition with new anti-tumoral Cu(II) complexes
Researcher
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013 - 2014/06 A Molecular Imaging Approach to Cystic Fibrosis
Principal investigator
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2012 - 2014 Target-specific and Heterobimetallic Platinum Complexes: Synthesis, Characterization and Mechanistic Studies
E-23/12
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
Concluded
2010 - 2012 Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation
PTDC/QUI-QUI/102049/2008
Researcher
Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2010 Metallo-drug design and action
COST Action D39
Researcher
2007 - 2008 A novel insight into CFTR Phosphorylation: implications for its processing, trafficking and function
PTDC/BIA-BCM/67058/2006
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2008 Novel post-genomic cell-based screens for drug targeting in membrane protein disorders- TargetScreen2
EU FP6-LSH-2005-037365
Post-doc
Universidade de Lisboa Faculdade de Ciências, Portugal
European Commission Sixth Framework Programme
Concluded
2002 - 2004 In search of new molecular targets for the development of novel therapeutic strategies for cystic fibrosis
POCTI/MGI/40878/2001
Other
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2000 - 2003 Thematic Network around Cystic Fibrosis and Related Diseases
EU FP5-QLK3-1999-00241
European Commission Sixth Framework Programme
2001 - 2002 Biogenesis and function of CFTR protein with different mutations: molecular basis for clinical and therapeutic heterogeneity of Cystic Fibrosis?
Other
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
1999 - 1999 Cystic Fibrosis - traffic and cellular function of CFTR
PRAXIS/PSAU/C/SAU/55/96
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Pinto, Catarina I. G.; Guerreiro JF; Francisco Silva; Mendes, Filipa; Paulo, António. Corresponding author: Paulo, António. "Radiopharmaceuticals for Molecular Imaging and Theranostics of Glioblastoma". In New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics. Elsevier, 2022.
    In press
  2. Matos, M; Mendes, Filipa; Valente, A.; Morais, T.S.; Zinck, P; Garcia, MH; Bicho, M.; Marques, F. "Ruthenium-based anticancer compounds: insights into their cellular targeting and mechanism of action". In Ruthenium Complexes - Photochemical and Biomedical Applications, edited by Alvin A. Holder; Jimmie L. Bullock; Welsey R. Browne; Mark A. LAwrence; Lothar Lilge. Wiley-VCH Verlag, 2017.
Conference abstract
  1. Ferreira, VFC; Guerreiro JF; Correia JG; Gonçalves J; Farinha CM; Mendes F. Corresponding author: Mendes F. "Development of molecular imaging tools to monitor drug efficacy through assessment of CFTR localization in vivo". Paper presented in North American Cystic Fibrosis Conference, 2021.
    Published
  2. Gano, Maria Lurdes; Vultos, F.; Fernandes, Célia; Mendes, Filipa; Correia, JDG. "Biological evaluation of radiolabelled peptides for oestrogen positive tumour theranostics". Paper presented in Annual Congress of the European Association of Nuclear Medicine October, Barcelona, 2019.
    Published
  3. Mendes, Filipa; Oliveira, Bruno L.; Morais, Mauricio; Raposinho, P.D.; Correia, JDG. "Radiometallated L-arginine derivatives for imaging nitric oxide synthase in vivo". Paper presented in 33rd European Peptide Symposium, Sofia, 2014.
    Published
  4. Ferreira, VFC; Oliveira, BL; Correia, JDG; Santos, I.; Farinha, CMF; Mendes, Filipa. "Cystic Fibrosis: new molecular imaging tools". Paper presented in 12th European Biological Inorganic Chemistry Conference, Zurich, 2014.
    Published
  5. Paulo, A.; Rodrigues, I.; Campello, M.P.C.; Morais, G.; Ferreira, VFC; Mendes, Filipa; Santos, I.; Gama, S.. "DNA Binding and Cytotoxic Activity of Zn(II) and Cu(II) Complexes with New Bis(thiosemicarbazone) Derivatives". Paper presented in 12th European Biological Inorganic Chemistry Conference, Zurich, 2014.
    Published
  6. Rodrigues, I.; Mendes, Filipa; Palma, E.; Correia, I.; Carvalho, MF; Cordeiro Dos Santos, I.; Marques, F.; et al. "New Mixed-Ligand Cu(II) Complexes Acting as “Self-activating” Chemical Nucleases". Paper presented in 12th European Biological Inorganic Chemistry Conference, Zurich, 2014.
    Published
  7. Neto, C.; Oliveira, MC; Fernandes, C.; Gano, Lurdes; Mendes, Filipa; Kniess, T.; Santos, I.. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". Paper presented in 19th International Symposium on Radiopharmaceutical Sciences, 2011.
    Published
  8. Mendes, Filipa; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Evaluation of 99mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance". Paper presented in Annual Congress of the EANM, Vienna, 2010.
    Published
  9. Gano, Lurdes; Mendes, Filipa; Fernandes, C.; Paulo, António; Santos, I.. "Biological Evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection". Paper presented in 15th European Symposium on Radiopharmacy and Radiopharmaceuticals, Edinburgh, 2010.
    Published
  10. Li, H.; Yang, W.; Mendes, Filipa; Amaral, MD; Sheppard, DN. "Renal cyst formation as tool for CFTR research". Paper presented in 31st European Cystic Fibrosis Conference, 2008.
    Published • 10.2118/4789-ms
  11. Dahimène S; Luz, S.; Mendes, Filipa; Almaça, J.; Barro-Soria, R.; Kunzelmann, K.; Amaral, MD. "Novel cellular models to identify rescuing of F508del-CFTR trafficking defect". Paper presented in 22nd Annual North American Cystic Fibrosis Conference, 2008.
    Published
  12. Mendes, Filipa; Vieira, I.; Alves, PC; Farinha, CMF; Amaral, MD. "Role of Bag-1 on the turnover and processing of wild-type and F508del-CFTR". Paper presented in 20th Annual North American Cystic Fibrosis Conference, Denver, 2006.
    Published
  13. Farinha, CMF; Mendes, Filipa; Roxo-Rosa, M.; Amaral, MD. "Low Temperature Studies Suggest Conformational Differences Between Wild-Type and F508del-CFTR". Paper presented in 20th Annual North American Cystic Fibrosis Conference, Denver, 2006.
    Published
  14. Ramalho, AS; Farinha, CMF; Mendes, Filipa; Neto, M.; Amaral, MD. "Lack of N-terminus causes major impairment on CFTR processing but does not abolish function". Paper presented in 19th Annual North American Cystic Fibrosis Conference, Baltimore, 2005.
    Published
  15. Mendes, Filipa; Wakefield, J.; Amaral, MD; Bebok, Z.; Penque, D.. "Characterization of a New Polarized Epithelial Cell Model to Study CFTR". Paper presented in 18th Annual North American Cystic Fibrosis Conference, Saint Louis, 2004.
    Published
  16. Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Effect of R555K or G550E traffic restoring substitutions upon A561E-CFTR processing". Paper presented in 25th Congress ECFS, 2002.
    Published
  17. Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Misprocessing of A561E-CFTR is partially corrected by R555K or G550E traffic Restoring Substitutions". Paper presented in 15th Annual North American Cystic Fibrosis Conference, Orlando, 2001.
    Published
  18. Mendes, Filipa; Penque, D.; Barroso, M.. "A Polarized Epithelial Cell Model to Study the Membrane Traffic of the Cystic Fibrosis Transmembrane Conductance Regulator". Paper presented in 2001 Annual ASCB Meeting, Washington, 2001.
    Published
Conference paper
  1. Antunes, Joana; Mendes, Filipa; Paulo, António; Sampaio, Jorge. "Modeling the radiobiological effects of gold nanoparticles in proton therapy of glioblastomas". 2021.
    10.22323/1.380.0040
  2. Di Maria S; Belchior, A.; Pereira, Edgar; Do Quental, L.; Oliveira, MC; Mendes, Filipa; Lavrado, J.; Paulo, António; Vaz, P.. "Dosimetry assessment of DNA damage by Auger-emitting radionuclides: Experimental and Monte Carlo studies". 2017.
    Published • 10.1016/j.radphyschem.2017.01.028
  3. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Perfusion and specific radioprobes for cardiac imaging". Paper presented in CARDIOTECHNIX 2013 - International Congress on Cardiovascular Technologies, Vilamoura, 2013.
    Published
Journal article
  1. Carina Marques Coelho; Lia Pereira; Pamela Teubig; Pedro Santos; Filipa Mendes; Sílvia Viñals; Daniel Galaviz; Federico Herrera. "Radiation as a Tool against Neurodegeneration—A Potential Treatment for Amyloidosis in the Central Nervous System". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232012265.
    10.3390/ijms232012265
  2. Matos, Cristina P.; Albino, Melissa; Lopes, Joana; Viana, Ana Silveira; Côrte-Real, Leonor; Mendes, Filipa; Pessoa, João Costa; et al. "New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes". International Journal of Pharmaceutics 623 (2022): 121925. http://dx.doi.org/10.1016/j.ijpharm.2022.121925.
    10.1016/j.ijpharm.2022.121925
  3. Célia Fernandes; Elisa Palma; Francisco Silva; Ana Belchior; Catarina I. G. Pinto; Joana F. Guerreiro; Hugo M. Botelho; et al. "Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus". International Journal of Molecular Sciences 23 13 (2022): 7238-7238. https://doi.org/10.3390/ijms23137238.
    10.3390/ijms23137238
  4. Ana B. Buades; Laura C. J. Pereira; Bruno J. C. Vieira; Ana C. Cerdeira; João C. Waerenborgh; Teresa Pinheiro; António P. A. Matos; et al. "The Mössbauer effect using 57Fe-ferrabisdicarbollide ([o-57FESAN]-): a glance into the potential of a low-dose approach for glioblastoma radiotherapy". Inorganic Chemistry Frontiers (2022): https://doi.org/10.1039/D1QI01513C.
    10.1039/D1QI01513C
  5. Miquel Nuez-Martinez; Catarina I. G. Pinto; Joana F. Guerreiro; Filipa Mendes; Fernanda Marques; Amanda Muñoz-Juan; Jewel Ann Maria Xavier; et al. "Cobaltabis(dicarbollide) ([o-COSAN]-) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma". Cancers (2021): https://doi.org/10.3390/cancers13246367.
    10.3390/cancers13246367
  6. Palma, Elisa; Raposinho, Paula; Cabral Campello, Maria Paula; Belo, Dulce; Guerreiro, Joana; Alves, Vitor; Fonseca, Alexandra; et al. "Anticancer Activity and Mode of Action of Copper (II)- Bisthiosemicarbazonato Complexes with Pendant Nitrogen Heterocycles". European Journal of Inorganic Chemistry (2021): http://dx.doi.org/10.1002/ejic.202100168.
    Accepted • 10.1002/ejic.202100168
  7. Vera F. C. Ferreira; Bruno L. Oliveira; Alice D’Onofrio; Carlos M. Farinha; Lurdes Gano; António Paulo; Gonçalo J. L. Bernardes; Filipa Mendes. "In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00551.
    10.1021/acs.bioconjchem.0c00551
  8. Ben Woods; Rúben D. M. Silva; Claudia Schmidt; Darren Wragg; Marco Cavaco; Vera Neves; Vera F. C. Ferreira; et al. "Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00659.
    10.1021/acs.bioconjchem.0c00659
  9. D'Onofrio, A.; Gano, L.; Melo, R.; Mendes, F.; Oliveira, M.C.; Denoël, T.; Schaefer, N.; et al. "Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 158 (2021): 233-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099854769&partnerID=MN8TOARS.
    10.1016/j.ejpb.2020.11.015
  10. Ferreira, VFC; Correia, JDG; Farinha, CMF; Mendes, Filipa. "Improved Fmoc-solid-phase peptide synthesis of an extracellular loop of CFTR for antibody selection by the phage display technology". Journal of Peptide Science (2020):
    Accepted • PSC-20-0035
  11. Tabacaru, A.; Dediu, A.V.B.; Dinica, R.M.; Carac, G.; Basliu, V.; Campello, M.P.C.; Silva, FFA; et al. "Biological properties of a new mixed lanthanide(III) complex incorporating a dypiridinium ylide". Inorganica Chimica Acta 506 (2020): http://dx.doi.org/10.1016/j.ica.2020.119517.
    In press • 10.1016/j.ica.2020.119517
  12. Mendes, Filipa; Gano, Lurdes; Grilo, J; Cunha, S; Fernandes, C.; Paulo, A.. "Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance". Cancer Drug Resistance (2020): http://dx.doi.org/10.20517/cdr.2019.86.
    Open access • Published • 10.20517/cdr.2019.86
  13. Guerreiro, J.F.; Gomes, M.A.G.B.; Pagliari, F.; Jansen, J.; Marafioti, M.G.; Nistico, C.; Hanley, R.; et al. "Iron and copper complexes with antioxidant activity as inhibitors of the metastatic potential of glioma cells". RSC Advances 10 22 (2020): 12699-12710. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083395557&partnerID=MN8TOARS.
    10.1039/d0ra00166j
  14. Pinto, C.I.G.; Bucar, S.; Alves, V.; Fonseca, A.; Abrunhosa, A.J.; da Silva, C.L.; Guerreiro, J.F.; Mendes, F.. "Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer". Frontiers in Molecular Biosciences 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85097663129&partnerID=MN8TOARS.
    10.3389/fmolb.2020.609172
  15. Alvarez-Valdes, A.; Matesanz, A.I.; Perles, J.; Fernandes, C.; Correia, J.D.G.; Mendes, F.; Quiroga, A.G.. "Novel structures of platinum complexes bearing N-bisphosphonates and study of their biological properties". Journal of Inorganic Biochemistry 191 (2019): 112-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057163055&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2018.11.010
  16. Joana Guerreiro; Vítor Alves; Antero Abrunhosa; António Paulo; Octávia Gil; Filipa Mendes. "Radiobiological Characterization of 64CuCl2 as a Simple Tool for Prostate Cancer Theranostics". Molecules (2018): https://doi.org/10.3390/molecules23112944.
    10.3390/molecules23112944
  17. Vera F. C. Ferreira; Bruno L. Oliveira; João D. Santos; João D. G. Correia; Carlos M. Farinha; Filipa Mendes. "Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe". ChemMedChem 13 14 (2018): 1469-1478. https://doi.org/10.1002/cmdc.201800187.
    10.1002/cmdc.201800187
  18. Palma, E.; Botelho, H.M.; Morais, G.R.; Rodrigues, I.; Santos, I.C.; Campello, M.P.C.; Raposinho, P.; et al. "Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies". Journal of Biological Inorganic Chemistry (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85057336330&partnerID=MN8TOARS.
    10.1007/s00775-018-1629-6
  19. Francisco Navas; Filipa Mendes; Isabel Santos; Carmen Navarro-Ranninger; Silvia Cabrera; Adoración G. Quiroga. "Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands". Inorganic Chemistry 56 11 (2017): 6175-6183. https://doi.org/10.1021/acs.inorgchem.7b00136.
    10.1021/acs.inorgchem.7b00136
  20. Maria Angeles Medrano; Maurício Morais; Vera F. C. Ferreira; João D. G. Correia; António Paulo; Isabel Santos; Carmen Navarro-Ranninger; et al. "Nonconventional trans -Platinum Complexes Functionalized with RDG Peptides: Chemical and Cytototoxicity Studies". European Journal of Inorganic Chemistry 2017 12 (2017): 1835-1840. https://doi.org/10.1002%2Fejic.201700072.
    10.1002/ejic.201700072
  21. Palma, E.; Mendes, F.; Morais, G.R.; Rodrigues, I.; Santos, I.C.; Campello, M.P.C.; Raposinho, P.; et al. "Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes". Journal of Inorganic Biochemistry 167 (2017): 68-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006054906&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2016.11.026
  22. Scalese, G.; Correia, I.; Benítez, J.; Rostán, S.; Marques, F.; Mendes, F.; Matos, A.P.; Costa Pessoa, J.; Gambino, D.. "Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands". Journal of Inorganic Biochemistry 166 (2017): 162-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995555569&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2016.11.010
  23. Pereira, E.; Do Quental, L.; Palma, E.; Oliveira, M.C.; Mendes, F.; Raposinho, P.; Correia, I.; et al. "Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85012284343&partnerID=MN8TOARS.
    10.1038/srep42544
  24. Quental, L.; Raposinho, P.; Mendes, F.; Santos, I.; Navarro-Ranninger, C.; Alvarez-Valdes, A.; Huang, H.; et al. "Combining imaging and anticancer properties with new heterobimetallic Pt(II)/M(i) (M = Re,99mTc) complexes". Dalton Transactions 46 42 (2017): 14523-14536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85024380558&partnerID=MN8TOARS.
    10.1039/c7dt00043j
  25. Vultos, F.; Fernandes, C.; Mendes, F.; Marques, F.; Correia, J.D.G.; Santos, I.; Gano, L.. "A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells". ChemMedChem 12 14 (2017): 1103-1107. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021713335&partnerID=MN8TOARS.
    10.1002/cmdc.201700287
  26. Morais, M.; Ferreira, V.F.C.; Figueira, F.; Mendes, F.; Raposinho, P.; Santos, I.; Oliveira, B.L.; et al. "Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters". Dalton Transactions 46 42 (2017): 14537-14547. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032622926&partnerID=MN8TOARS.
    10.1039/c7dt01146f
  27. Sofia Gama; Inês Rodrigues; Filipa Mendes; Isabel C. Santos; Elisabetta Gabano; Beata Klejevskaja; Jorge Gonzalez-Garcia; et al. "Anthracene-terpyridine metal complexes as new G-quadruplex DNA binders". Journal of Inorganic Biochemistry 160 (2016): 275-286. https://doi.org/10.1016%2Fj.jinorgbio.2016.04.002.
    10.1016/j.jinorgbio.2016.04.002
  28. Leite, S.M.G.; Lima, L.M.P.; Gama, S.; Mendes, F.; Orio, M.; Bento, I.; Paulo, A.; Delgado, R.; Iranzo, O.. "Copper(II) complexes of phenanthroline and histidine containing ligands: Synthesis, characterization and evaluation of their DNA cleavage and cytotoxic activity". Inorganic Chemistry 55 22 (2016): 11801-11814. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998678731&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.6b01884
  29. Kydonaki, T.E.; Tsoukas, E.; Mendes, F.; Hatzidimitriou, A.G.; Paulo, A.; Papadopoulou, L.C.; Papagiannopoulou, D.; Psomas, G.. "Synthesis, characterization and biological evaluation of 99mTc/Re-tricarbonyl quinolone complexes". Journal of Inorganic Biochemistry 160 (2016): 94-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84970002369&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.12.010
  30. Oliveira, B.L.; Morais, M.; Mendes, F.; Moreira, I.S.; Cordeiro, C.; Fernandes, P.A.; Ramos, M.J.; et al. "Re(I) and Tc(I) Complexes for Targeting Nitric Oxide Synthase: Influence of the Chelator in the Affinity for the Enzyme". Chemical Biology and Drug Design 86 5 (2015): 1072-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944163069&partnerID=MN8TOARS.
    10.1111/cbdd.12575
  31. Fernandes, T.A.; Mendes, F.; Roseiro, A.P.S.; Santos, I.; Carvalho, M.F.N.N.. "Insight into the cytotoxicity of polynuclear Cu(I) camphor complexes". Polyhedron 87 (2015): 215-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-84916897699&partnerID=MN8TOARS.
    10.1016/j.poly.2014.11.020
  32. Gabano, E.; Gama, S.; Mendes, F.; Fregonese, F.; Paulo, A.; Ravera, M.. "Application of microwave-assisted heating to the synthesis of Pt(II) complexes". Inorganica Chimica Acta 437 (2015): 16-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939800779&partnerID=MN8TOARS.
    10.1016/j.ica.2015.07.042
  33. Nunes, P.; Morais, G.R.; Palma, E.; Silva, F.; Oliveira, M.C.; Ferreira, V.F.C.; Mendes, F.; et al. "Isostructural Re(i)/<sup>99m</sup>Tc(i) tricarbonyl complexes for cancer theranostics". Organic and Biomolecular Chemistry 13 18 (2015): 5182-5194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928905685&partnerID=MN8TOARS.
    10.1039/c5ob00124b
  34. Côrte-Real, L.; Mendes, F.; Coimbra, J.; Morais, T.S.; Tomaz, A.I.; Valente, A.; Garcia, M.H.; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". Journal of Biological Inorganic Chemistry 19 6 (2014): 853-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905864221&partnerID=MN8TOARS.
    10.1007/s00775-014-1120-y
  35. Adriaenssens, L.; Liu, Q.; Chaux-Picquet, F.; Tasan, S.; Picquet, M.; Denat, F.; Le Gendre, P.; et al. "Novel heterobimetallic radiotheranostic: Preparation, activity, and biodistribution". ChemMedChem 9 7 (2014): 1567-1573. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903819569&partnerID=MN8TOARS.
    10.1002/cmdc.201300494
  36. Santos, I.; Gama, S.; Rodrigues, I.; Marques, F.; Palma, E.; Correia, I.; Carvalho, M.F.N.N.; et al. "New ternary bipyridine-terpyridine copper(ii) complexes as self-activating chemical nucleases". RSC Advances 4 106 (2014): 61363-61377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912051462&partnerID=MN8TOARS.
    10.1039/c4ra12085j
  37. Herrera, J.M.; Mendes, F.; Gama, S.; Santos, I.; Navarro Ranninger, C.; Cabrera, S.; Quiroga, A.G.. "Design and biological evaluation of new platinum(II) complexes bearing ligands with DNA-targeting ability". Inorganic Chemistry 53 23 (2014): 12627-12634. http://www.scopus.com/inward/record.url?eid=2-s2.0-84914141357&partnerID=MN8TOARS.
    10.1021/ic502373n
  38. Moura, C.; Mendes, F.; Gano, L.; Santos, I.; Paulo, A.. "Mono- and dicationic Re(I)/99mTc(I) tricarbonyl complexes for the targeting of energized mitochondria". Journal of Inorganic Biochemistry 123 (2013): 34-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874931259&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.02.008
  39. Gabano, E.; Gama, S.; Mendes, F.; Gariboldi, M.B.; Monti, E.; Bombard, S.; Bianco, S.; Ravera, M.. "Study of the synthesis, antiproliferative properties, and interaction with DNA and polynucleotides of cisplatin-like Pt(II) complexes containing carcinogenic polyaromatic amines". Journal of Biological Inorganic Chemistry 18 7 (2013): 791-801. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885598920&partnerID=MN8TOARS.
    10.1007/s00775-013-1022-4
  40. Moura, C.; Gano, L.; Mendes, F.; Raposinho, P.D.; Abrantes, A.M.; Botelho, M.F.; Santos, I.; Paulo, A.. "99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation". European Journal of Medicinal Chemistry 50 (2012): 350-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858449323&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.02.014
  41. Gama, S.; Mendes, F.; Esteves, T.; Marques, F.; Matos, A.; Rino, J.; Coimbra, J.; et al. "Synthesis and Biological Studies of Pyrazolyl-Diamine PtII Complexes Containing Polyaromatic DNA-Binding Groups". ChemBioChem 13 16 (2012): 2352-2362. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868093608&partnerID=MN8TOARS.
    10.1002/cbic.201200472
  42. Tomaz, A.I.; Jakusch, T.; Morais, T.S.; Marques, F.; De Almeida, R.F.M.; Mendes, F.; Enyedy, É.A.; et al. "[RuII(¿5-C5H5 (bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin". Journal of Inorganic Biochemistry 117 (2012): 261-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869080345&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2012.06.016
  43. Mendes, F.; Farinha, C.M.; Felício, V.; Alves, P.C.; Vieira, I.; Amaral, M.D.. "BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner". Cellular Physiology and Biochemistry 30 5 (2012): 1120-1133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869203984&partnerID=MN8TOARS.
    10.1159/000343303
  44. Serratrice, M.; Edafe, F.; Mendes, F.; Scopelliti, R.; Zakeeruddin, S.M.; Grätzel, M.; Santos, I.; Cinellu, M.A.; Casini, A.. "Cytotoxic gold compounds: Synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1". Dalton Transactions 41 11 (2012): 3287-3293. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857563583&partnerID=MN8TOARS.
    10.1039/c2dt11913g
  45. Li, H.; Yang, W.; Mendes, F.; Amaral, M.D.; Sheppard, D.N.. "Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth". American Journal of Physiology - Renal Physiology 303 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867719641&partnerID=MN8TOARS.
    10.1152/ajprenal.00130.2012
  46. Neto, C.; Fernandes, C.; Oliveira, M.C.; Gano, L.; Mendes, F.; Kniess, T.; Santos, I.. "Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents". Nuclear Medicine and Biology 39 2 (2012): 247-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856346831&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2011.09.001
  47. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent". Nuclear Medicine and Biology 39 2 (2012): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856362049&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2011.08.007
  48. Can, D.; Spingler, B.; Schmutz, P.; Mendes, F.; Raposinho, P.; Fernandes, C.; Carta, F.; et al. "(M=Re or 99mTc) arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX". Angewandte Chemie - International Edition 51 14 (2012): 3354-3357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859226949&partnerID=MN8TOARS.
    10.1002/anie.201107333
  49. Gama, S.; Santos, I.; Mendes, F.; Marques, F.; Santos, I.C.; Carvalho, M.F.; Correia, I.; Pessoa, J.C.; Paulo, A.. "Copper(II) complexes with tridentate pyrazole-based ligands: Synthesis, characterization, DNA cleavage activity and cytotoxicity". Journal of Inorganic Biochemistry 105 5 (2011): 637-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066808&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2011.01.013
  50. Mendes, F.; Groessl, M.; Nazarov, A.A.; Tsybin, Y.O.; Sava, G.; Santos, I.; Dyson, P.J.; Casini, A.. "Metal-based inhibition of poly(ADP-ribose) polymerase-the guardian angel of DNA". Journal of Medicinal Chemistry 54 7 (2011): 2196-2206. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953796119&partnerID=MN8TOARS.
    10.1021/jm2000135
  51. Mendes, F.; Paulo, A.; Santos, I.. "Metalloprobes for functional monitoring of tumour multidrug resistance by nuclear imaging". Dalton Transactions 40 20 (2011): 5377-5393. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955600298&partnerID=MN8TOARS.
    10.1039/c0dt01275k
  52. Francisco, C.; Gama, S.; Mendes, F.; Marques, F.; Cordeiro Dos Santos, I.; Paulo, A.; Santos, I.; et al. "Pt(ii) complexes with bidentate and tridentate pyrazolyl-containing chelators: Synthesis, structural characterization and biological studies". Dalton Transactions 40 21 (2011): 5781-5792. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957530790&partnerID=MN8TOARS.
    10.1039/c0dt01785j
  53. Oliveira, B.L.; Raposinho, P.D.; Mendes, F.; Santos, I.C.; Santoes, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.; Correia, J.D.G.. "Targeting nitric oxide synthase with 99mTc/Re-tricarbonyl complexes containing pendant guanidino or isothiourea moieties". Journal of Organometallic Chemistry 696 5 (2011): 1057-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952194212&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2010.09.019
  54. Oliveira, B.L.; Raposinho, P.D.; Mendes, F.; Figueira, F.; Santos, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.; Correia, J.D.G.. "Re and Tc tricarbonyl complexes: From the suppression of NO biosynthesis in macrophages to in vivo targeting of inducible nitric oxide synthase". Bioconjugate Chemistry 21 12 (2010): 2168-2172. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650341241&partnerID=MN8TOARS.
    10.1021/bc100291e
  55. Esteves, T.; Xavier, C.; Gama, S.; Mendes, F.; Raposinho, P.D.; Marques, F.; Paulo, A.; et al. "Tricarbonyl M(I) (M = Re, 99mTc) complexes bearing acridine fluorophores: Synthesis, characterization, DNA interaction studies and nuclear targeting". Organic and Biomolecular Chemistry 8 18 (2010): 4104-4116. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955948795&partnerID=MN8TOARS.
    10.1039/c0ob00073f
  56. Ramalho, A.S.; Lewandowska, M.A.; Farinha, C.M.; Mendes, F.; Gonçalves, J.; Barreto, C.; Harris, A.; Amaral, M.D.. "Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients". Cellular Physiology and Biochemistry 24 5-6 (2009): 335-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450231758&partnerID=MN8TOARS.
    10.1159/000257426
  57. Schmidt, A.; Hughes, L.K.; Cai, Z.; Mendes, F.; Li, H.; Sheppard, D.N.; Amaral, M.D.. "Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator". British Journal of Pharmacology 153 6 (2008): 1311-1323. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349033879&partnerID=MN8TOARS.
    10.1038/sj.bjp.0707663
  58. Mendes, F.; Wakefield, J.; Bachhuber, T.; Barroso, M.; Bebok, Z.; Penque, D.; Kunzelmann, K.; Amaral, M.D.. "Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies". Cellular Physiology and Biochemistry 16 4-6 (2005): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-27844525431&partnerID=MN8TOARS.
    10.1159/000089857
  59. Mendes, F.; Farinha, C.M.; Roxo-Rosa, M.; Fanen, P.; Edelman, A.; Dormer, R.; McPherson, M.; et al. "Antibodies for CFTR studies". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 69-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944369736&partnerID=MN8TOARS.
    10.1016/j.jcf.2004.05.016
  60. Harris, C.M.; Mendes, F.; Dragomir, A.; Doull, I.J.M.; Carvalho-Oliveira, I.; Bebok, Z.; Clancy, J.P.; et al. "Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 43-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944385576&partnerID=MN8TOARS.
    10.1016/j.jcf.2004.05.009
  61. Mendes, F.; Doucet, L.; Hinzpeter, A.; Féree, C.; Lipecka, J.; Fritsch, J.; Edelman, A.; et al. "Immunohistochemistry of CFTR in native tissues and primary epithelial cell cultures". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 37-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944422399&partnerID=MN8TOARS.
    10.1016/j.jcf.2004.05.008
  62. Farinha, C.M.; Mendes, F.; Roxo-Rosa, M.; Penque, D.; Amaral, M.D.. "A comparison of 14 antibodies for the biochemical detection of the cystic fibrosis transmembrane conductance regulator protein". Molecular and Cellular Probes 18 4 (2004): 235-242. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242674336&partnerID=MN8TOARS.
    10.1016/j.mcp.2004.03.005
  63. Mendes, F.; Rosa, M.R.; Dragomir, A.; Farinha, C.M.; Roomans, G.M.; Amaral, M.D.; Penque, D.. "Unusually common cystic fibrosis mutation in Portugal encodes a misprocessed protein". Biochemical and Biophysical Research Communications 311 3 (2003): 665-671. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242577536&partnerID=MN8TOARS.
    10.1016/j.bbrc.2003.10.048
  64. Doucet, L.; Mendes, F.; Montier, T.; Delépine, P.; Penque, D.; Férec, C.; Amaral, M.D.. "Applicability of different antibodies for the immunohistochemical localization of CFTR in respiratory and intestinal tissues of human and murine origin". Journal of Histochemistry and Cytochemistry 51 9 (2003): 1191-1199. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041819843&partnerID=MN8TOARS.
  65. Farinha, C.M.; Nogueira, P.; Mendes, F.; Penque, D.; Amaral, M.D.. "The human Dnaj homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70". Biochemical Journal 366 3 (2002): 797-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037106481&partnerID=MN8TOARS.
    10.1042/BJ20011717
  66. Zaman, K.; McPherson, M.; Vaughan, J.; Hunt, J.; Mendes, F.; Gaston, B.; Palmer, L.A.. "S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation". Biochemical and Biophysical Research Communications 284 1 (2001): 65-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034804969&partnerID=MN8TOARS.
    10.1006/bbrc.2001.4935
  67. Penque, D.; Mendes, F.; Beck, S.; Farinha, C.; Pacheco, P.; Nogueira, P.; Lavinha, J.; Malhó, R.; Amaral, M.D.. "Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells". Laboratory Investigation 80 6 (2000): 857-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033918281&partnerID=MN8TOARS.

Intellectual property

Patent
  1. Garcia, MH; Morais, T.S.; Tomaz AI; Marques F; Mendes, Filipa. 2013. "Transition metal complexes for pharmaceutical applications".
    Granted/Issued
  2. Amaral, MD; Dahimène S; Mendes, Filipa. 2011. "Two novel human epithelial cell lines to be used in assays for traffic studies/ screens of CFTR protein (wild-type and with the F508del mutation". Portugal.
    Pending
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/09 Health and Environment Research Areas at C2TN First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies)
2019/09/12 Assessment of CFTR localization in vivo to monitor efficacy of CFTR correctors Invited Talk - REAP Expert Meeeting
European Cystic Fibrosis Society (ECFS) (Lisboa, Portugal)
2019/09 New insights on the radiobiological effects of 64CuCl2 - a simple tool for prostate cancer theranostics I NOVA Biophysica Internacional Conference
(Lisboa, Portugal)
2019/03 Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe 16th European Cystic Fibrosis Basic Science Conference
European Cystic Fibrosis Society (Dubrovnik, Croatia)
2018/06 Molecular and Cell Biology methods for validation of (imaging) biomarkers Summer School “Development and Pre-clinical Evaluation of Radiopharmaceuticals”
Marie Curie Innovative Training Network "MEDICIS-Promed" (Cascais, Portugal)
2017/11 Ionizing radiation and health: Imaging and exposure biomarkers Physics Department seminars
Physics Departmentm, IST (Lisboa, Portugal)
2014/08 Molecular Imaging probes for in vivo detection of the Cystic Fibrosis Protein 2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules
COST Action CM1105 (Zurich, Switzerland)
2014/05 Biological relevance and general applications of peptides Training School “Peptides for Targeted Drug Delivery"
COST Action CM1105“Functional metal complexes that bind to biomolecules” (Bobadela LRS, Portugal)
2014/04 Biomarkers for the Theranostic Strategy - Cancer and Molecular Theranostics Expert meeting
COST action CM1105 (Bobadela LRS, Portugal)
2013/10 New Platinum (II) complexes with DNA-targeting ability 1st Meeting on Functional metal complexes that bind to biomolecules
COST ACTION CM1105 (Barcelona, Spain)
2013/09 Perfusion and specific radioprobes for cardiac imaging Cardiotecnhix International Congress on Cardiovascular Technologies
Cardiotecnhix (Vilamoura, Portugal)
2012/12 Imaging in the era of molecular oncology: new probes for detection of multidrug resistance Bioengineering Department Seminars
IST (Lisboa, Portugal)
2012/12 Sondas para Imagiologia Cardiovascular Workshop “Biomarcadores sanguíneos e imagiologia da placa aterosclerótica”
Instituto Superior Técnico (Sacavém, Portugal)
2012/10 From cardiology to oncology: new radioactive probes for detection of cancer multidrug resistance Chem Forum -Autumn Edition
IST (Lisboa, Portugal)
2008/12 Pharmacogenomics – contribute for cancer therapeutics Symposium Cancer and Therapeutic Approaches
Universidade Lusófona de Humanidades e Tecnologias (Lisboa, Portugal)
2007 An approach to chaperone therapy: correcting the basic defect in Cystic Fibrosis V International Symposium Sociedade Portuguesa de Doenças Metabólicas
Sociedade Portuguesa de Doenças Metabólicas (Porto, Portugal)
2007 Role of Bag-1 in turnover and processing of wild-type and F508del-CFTR Workshop Proteins in Health and Disease: from structure to function
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2006 Modulation of CFTR biosynthesis and maturation by molecular chaperones: implications for Cystic Fibrosis Dia do Jovem Investigador do Instituto Ricardo Jorge
Instituto Ricardo Jorge (Lisboa, Portugal)
2004 Characterization of a New Polarized Epithelial Cell Model to Study the Cystic Fibrosis Transmembrane Conductance Regulator New Frontiers in the Basic Science of Cystic Fibrosis
European Cystic Fibrosis Society (Tomar, Portugal)
1999 Imunolocalização da proteína F508del-CFTR na região apical de células epiteliais nasais XXXIV Reun Ann Soc Port Mic Electr e Biol Cel
Sociedade Portuguesa de Microscopia Electrónica e Biologia Celular (Lisboa, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/02 - Current Targeting of cationic amino acid transporters with radiometallated amino acids for cancer theranostics
Co-supervisor
Chemistry (PhD)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021/02 - Current Biological evaluation of copper-64 chloride as a promising tool for cancer theranostics
Supervisor
Biomedical Engineering (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02 - Current Modeling radiobiological effects of nanoparticles in proton therapy of glioblastomas
Co-supervisor
Biomedical and Biophysics Engineering (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/02 - Current Quantification of biological effects induced by low doses of X-rays in non-tumoral breast cells
Co-supervisor of Ana Filipa Inácio
Radiation Protection and Safety (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/07 Novel antibody fragments - selection and validation as Cystic Fibrosis imaging tools
Supervisor
Microbiology (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/06 Avaliação pré-clínica de novas terapias anti-tumorais em modelos celulares 3D de cancro da mama
Supervisor
Bioengineering: Regenerative and Precision Medicine (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/03 - 2022/11 Antibody Conjugates for Combined Anticancer Radio- and Chemotherapy
Co-supervisor
MSc Biological Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/04 - 2021/12 Postdoctoral Fellow recruited by the grant "A Molecular Imaging Approach to Cystic Fibrosis"
Supervisor of Joana Guerreiro
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09/01 - 2021/04 Master Fellowship in UTAustin TOF-PET project
Supervisor
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2016/02 - 2020/10/08 New Molecular Imaging tools for Cystic Fibrosis
Supervisor of Vera Filipa Ferreira
Biotechnology and Biosciences (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/02 - 2019/10 Development of 3D spheroid cultures of cancer cells for the preclinical evaluation of a novel theranostic agents
Supervisor of Catarina Isabel Pinto
Biomedical Engeneering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/01 - 2018/10 Cystic Fibrosis: novel molecular imaging tools
Supervisor of Mariana Anderson Morais David
Biological Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/09 - 2015 Research Fellow Vera Ferreira, MSc in the framework of the projects EXPL/BIM-MEC/0115/2012 (Set2013-Set2014) and ProQr Therapeutics (Aug –Dec 2015)
Supervisor
Centro de Ciências e Tecnologias Nucleares, Portugal
2013/09 - 2013/12 Medicina Nuclear Convencional e o seu contributo diagnóstico no Carcinoma da Próstata localizado e metastizado
Supervisor of Inês Matreno
Monography - Nuclear Medicine (Other)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/11 - 2013/09 Biological Evaluation of cationic 99mTc(I) complexes as probes for tumoral detection and functional monitoring of multidrug resistance
Supervisor of Fernando Toscano
Biomedical Inorganic Chemistry - applications in diagnostic and therapy (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2013/07 A Molecular Imaging approach to Cystic Fibrosis
Supervisor of Vera Filipa Ferreira
Biochemistry (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2012/12 99mTc(I) tricarbonyl complexes for mitochondria targeting
Supervisor of Ana Bárbara Pereira
Undergraduate research project in Nuclear Medicine (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/01 - 2012/07 In vitro evaluation of 99mTc(I) complexes as probes for tumoral detection: influence of the plasma membrane and mitochondrial membrane potential on the cell uptake
Supervisor of Teresa Pinto
Undergraduate research project - Nuclear Medicine (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011/09 - 2011/12 Utilização de radiofármacos de 99mTc para monitorização funcional de resistência a múltiplos fármacos
Supervisor of Teresa Pinto
Undergraduate research project - Nuclear Medicine (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2006/09 - 2007/07 Intracellular trafficking of CFTR in polarized cells
Co-supervisor of Simão Filipe Luz
Biochemistry (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021/07 - Current Chair of the Organizing Committee of the Workshop 2021 Thematic Strand Radiopharmaceutical Sciences and Health Physics (2021)
Workshop (President of the Organising Committee)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021 - Current Member of the Organizing Committee “First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies), online, September 2021 (2021)
Workshop (Member of the Organising Committee)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2019/11 - 2019/11 Member of the Organizing Committee of the “Workshop 2019 Thematic Strand Radiopharmaceutical Sciences and Health Physics” (2019/11 - 2019/11)
Workshop (Member of the Organising Committee)
Centro de Ciências e Tecnologias Nucleares, Portugal
2017/12 - 2017/12 Member of the Organizing Committee of the “1St C2TN workshop- radiation for science and society” (2017/12 - 2017/12)
Workshop (Member of the Organising Committee)
Centro de Ciências e Tecnologias Nucleares, Portugal
2015/11 - 2015/11 Member of the Organizing Committee of the ““Imaging and Radiation Biomarkers Workshop” organized by the IST at C2TN, Universidade de Lisboa, November 2015. (2015/11 - 2015/11)
Workshop (Member of the Organising Committee)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2004 - 2008 Member of the Organizing Committee of the “European Cystic Fibrosis Society Conference - New Frontiers in the Basic Science of Cystic Fibrosis” – 5 editions in Portugal: 2004 in Tomar, 2005 in Évora, 2006 in Carvoeiro, 2007 in Tavira and 2008 in Régua. (2004 - 2008)
Conference (Member of the Organising Committee)
European Cystic Fibrosis Society, Denmark
2007/07 - 2007/07 Member of the Organizing Committee of the “Workshop on Epithelial Biology: Epithelial cells & tissues: production, cultivation and characterization”, organized by the EuroCareCF - (EU) (2007/07 - 2007/07)
Workshop (Member of the Organising Committee)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
1999 - Current Participation in International and National Scientific Conferences from Cell Biology, Cystic Fibrosis, Medicinal/Bioinorganic Chemistry, Molecular Imaging and Radiopharmaceutical fields - 93 posters in international meetings and 18 in portuguese conferences.
Congress
2018/04 - 2018/04 Invited panelist at the “New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications” Organized by IST and IAEA (International atomic energy agency)
Round table
New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications
Universidade de Lisboa Instituto Superior Técnico, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2022/09 Susceptibilidade dos individuos portadores de mutacoes BRCA1 e BRCA 2 a radiacao de diagnostico
(Thesis) Main arguer
Diana Pereira Goncalves (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/11 RA-223 no tratamento do carcinoma da próstata metastático
(Thesis) Main arguer
Carolina Alves Silva (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/03/30 Regulation of the TGF-ß1 signaling in cystic fibrosis: the role of LMTK2
(Thesis) Arguer
Daniel Filipe Soares Pereira da Cruz (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/05 Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks
(Thesis) Main arguer
Claúdia Almeida Pires Loureiro (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09 Search for new modulators of Phe508del-CFTR retention at the plasma membrane of epithelial cells
(Thesis) Main arguer
Ana Margarida Fernandes Pereira de Matos (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/10 Characterization of CFTR orphan mutations
(Thesis) Main arguer
Sofia Santos Ramalho (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/10 Desenvolvimento de um biossensor molecular para o estudo translacional da Fibrose Quística e outras doenças respiratórias
(Thesis) Main arguer
Angela Dias Alves (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/05 Estudio y dieseño de complejos antitumorales de Pt(II) y Pt(IV), usando nuevas estrategias para conseguir una mayor actividad y especificidade
Thesis Member
Medrano MA (PhD)
Fundación de la Universidad Autónoma de Madrid, Spain
2012/10 Complexos de Ruténio como potenciais agentes terapêuticos: estudos dos mecanismos de captação celular e modulação de enzimas metabólicos
(Thesis) Main arguer
Leonor Corte-Real (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/02 Tc(I)/Re(I) Organometallic for Molecular Imaging of Neoplasic Tissues
(Thesis) Arguer
Carolina Moura (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/12 Recruitment of Pyk2 during complement mediated phagocytosis and expression of kinase domains in insect cell
(Thesis) Main arguer
Carina Santos (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008/06 Characterization of the impact of a novel antimicrobial photosensitizer
(Thesis) Main arguer
Sónia Alexandra Gonçalves Mendes (Master)
Universidade Católica Portuguesa, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022 - Current Cancers MDPI
2022 - Current Biology MDPI
2020 - Current Bioconjugate Chemistry ACS
2020 - Current Molecules MDPI
2019 - Current JBIC Journal of Biological Inorganic Chemistry (1432-1327) Springer-Verlag
2019 - Current Coordination Chemistry Reviews (0010-8545) Elsevier
2019 - Current ChemistrySelect Wiley-VCH Verlag

Association member

Society Organization name Role
2021/04/01 - Current American Society of Chemistry
2013 - Current Society of Biological Inorganic Chemistry
2010 - Current European Association of Nuclear Medicine
2004 - Current Cystic Fibrosis European Network
2001 - Current American Society of Cell Biology
1999 - Current Ordem dos Biólogos

Conference scientific committee

Conference name Conference host
2015 - 2015 LOWDOSE-PT-2015 - Biological effects and risks of low dose and protracted exposures to ionizing radiation Instituto Superior Técnico

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013 - Current Genetic Engeneering Engenharia Biomédica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - Current Molecular Biotechnology Biotecnologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2012 Pharmacogenomics Ciências Farmacêuticas (Mestrado Intregado) (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2007/07 - 2007/07 Workshop on Epithelial Biology: “Epithelial cells & tissues: production, cultivation and characterization”, organized by the EurocareCF Coordination Action (Outros) Universidade de Lisboa Faculdade de Ciências, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2017 - Current Reviewer for the European Science Foundation - expert panel Life and Health Sciences
Evaluator
European Science Foundation, France Fonds Wetenschappelijk Onderzoek Vlaanderen

Université de Bordeaux

Università degli Studi di Torino

AXA SA

Journal scientific committee

Journal title (ISSN) Publisher
2022 - Current Frontiers in Molecular Biosciences - special topic editor Frontiers
2021 - Current Molecules - special issue editor MDPI
2021 - Current Fontiers in Medicine -Nuclear Medicine - review editor Frontiers
Distinctions

Award

2006 Medal for Women in Science-Portugal - Medalha L'oreal para as Mulheres na Ciência L'oreal
2005 Gulbenkian Award for Research Incentive - Programa Gulbenkian de Estímulo à Investigação

Other distinction

2020 Diploma for Excellence in Education (Diploma de Excelência no Ensino)
2019 Diploma for Excellence in Education (Diploma de Excelência no Ensino)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Diploma for Excellence in Education (Diploma de Excelência no Ensino)
Universidade de Lisboa Instituto Superior Técnico, Portugal