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Joana Ferreira, graduated in Biology in 2006 (University of Coimbra) and completed her PhD in Biosciences, specialty Neurosciences (University of Coimbra) in 2012, under the co-supervision of Ana Luísa Carvalho at the Center for Neuroscience and Cell Biology (University of Coimbra, Portugal) and Ann Marie Craig at the Center for Brain Health (University of British Columbia, Vancouver, Canada). After completing her PhD, she stayed at the Center for Neuroscience and Cell Biology (CNC) as a postdoctoral fellow to complete her studies on the molecular mechanisms of traffic of glutamate receptors. In 2016 she joined the group of Laurent Groc, at the Interdisciplinary Institute for Neuroscience (CNRS, University of Bordeaux, France), to explore the regulation of the nanoscale distribution of NMDA receptors (NMDARs). Recently she has joined the CNC-UC as an Assistant Investigator to start her independent line of research on the nanoscale architecture of the synapse, trans-synaptic signaling and its implications for neurological diseases. She has an extensive and recognized experience in molecular imaging of NMDARs and its interactors and a broad background in molecular neuroscience, with a specific training in super-resolution microscopy techniques. As a young-researcher, she has achieved a successful track-record: 9 publications as first-author in high-impact peer review reference journals, including Neuron and PNAS, out of a total of 17 publications, 2 of them as co-corresponding author. She has supervised several students (2 master students from the University of Bordeaux, 1 from the University of Bialystok, Poland and 1 graduate student from the University of Coimbra) and mentored several PhD students in the laboratory. She has participated as an instructor at the CAJAL Advanced Neuroscience Training Program in Bordeaux, as a lecture in several advanced courses from the PhD Program in Experimental Biology and Biomedicine (PDBEB), and as a teacher in the Molecular Biology course from the Master Program of the University of Coimbra (UC). She has been invited as a jury member by the Bordeaux International Neuroscience Master Program and the Molecular Biology Master Program of the University of Coimbra, and for a PhD thesis committee of the Nova Lisbon University. She has successfully organized an international symposium (2017 FENS Regional Meeting, Hungary), a workshop at one of the biggest microscopy schools in Europe (MiFoBio 2018, France), and an advanced course for PhD students (Advanced Imaging, 2022, PDBEB, UC). She is the Principal Investigator (PI) of 2 international grants (IBRO and NARSAD), co-PI in a consortium project funded by La Caixa Foundation Health Research 2020, and has participated in 8 funded research projects, 18 international scientific meetings, 7 of them as an invited speaker. Recently, she has been awarded with the prestigious 2021 BBRF Young Investigator Grant from the Brain&Behavior Research Foundation and the IBRO Return Home Fellowship.
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Identificação

Identificação pessoal

Nome completo
Joana Ferreira

Nomes de citação

  • Ferreira, Joana S

Identificadores de autor

Ciência ID
0E15-84D6-0BF4
ORCID iD
0000-0002-1049-8063

Endereços de correio eletrónico

  • joanaferreira@cnc.uc.pt (Profissional)

Moradas

  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra (CNC-UC), Faculdade de Medicina, 2º piso, Rua Larga , 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A2)
Formação
Grau Classificação
2008/01/01 - 2012/06/19
Concluído
 Biociências (Doutoramento)
Especialização em Neurociências
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Center for Neuroscience and Cell Biology, Portugal
"Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA type: Implications in Synaptic Plasticity" (TESE/DISSERTAÇÃO)
 Aprovado com distinção e louvor
2001/09/22 - 2006/06/20
Concluído
 Biology (Pre-Bolonha, 4 years) (Licenciatura)
Especialização em Scientific
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"N/A" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/06/01 - Atual Investigador Auxiliar (carreira) (Investigação) University of Coimbra, Portugal
Center for Neuroscience and Cell Biology, Portugal
2016/01/01 - 2021/05/15 Investigador Contratado (Investigação) Institut Interdisciplinaire de Neurosciences, França
Université de Bordeaux, França
(...)
2013/01/01 - 2015/12/31 Pós-doutorado (Investigação) CNC.IBILI, Portugal
Universidade de Coimbra, Portugal
2013/09/04 - 2014/09/03 Investigador visitante (Investigação) Institut Interdisciplinaire de Neurosciences, França
Centre National de la Recherche Scientifique, França
(...)
2012/01/01 - 2012/12/31 Assistente de Investigação (carreira) (Investigação) Center for Neuroscience and Cell Biology, Portugal
Universidade de Coimbra, Portugal
2008/01/01 - 2012/06/20 Estagiário de Investigação (Investigação) Center for Neuroscience and Cell Biology, Portugal
2008/05/01 - 2008/12/31 Investigador visitante (Investigação) Djavad Mowafaghian Centre for Brain Health, Canadá
The University of British Columbia Department of Medicine Division of Neurology, Canadá
2006/07/01 - 2007/12/31 Assistente de Investigação (carreira) (Investigação) Center for Neuroscience and Cell Biology, Portugal
Universidade de Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01/01 - 2026/12/31 Homeostatic plasticity defects in autism: insight from human mutations in the CNTNAP2 gene
607/C/2022
Investigador
La Fundació La Marató de TV3
Em curso
2022/01/01 - 2024/12/31 The study of the novel NMDA receptor-Neurexin-2 interaction and potential role in schizophrenia
29902
Investigador responsável
Universidade de Coimbra, Portugal
 Brain & Behavior Research Foundation
Em curso
2023/03/01 - 2024/08/31 A New TransSynaptic Bridge: Functional characterization of the NMDA receptor-Neurexin interaction
2022.05386.PTDC
Investigador responsável
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/09/15 - 2023/08/15 Potassium channel dysfunction in models of neurodevelopmental disorders
LCF/PR/HP20/52300003
Investigador responsável
Institut Interdisciplinaire de Neurosciences, França
 ”la Caixa” Foundation
Em curso
2021/06/01 - 2023/05/31 Functional characterization of a novel transsynaptic complex
IBRO Return Home Fellowship 2021
Investigador responsável
Center for Neuroscience and Cell Biology, Portugal

Universidade de Coimbra, Portugal
International Brain Research Organization
Em curso
2013/01/01 - 2015/12/31 The Role of GluN2B-Containing NMDA Receptors in Regulating the Synaptic Proteasome: Implications to AMPA Receptor Traffic
SFRH/BPD/90045/2012
Bolseiro de Pós-Doutoramento
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/01/01 - 2012/12/31 Regulation of the stability of the messenger RNA for the GluR1 subunit of glutamate receptors
PTDC/BIA-BCM/113738/2009
Bolseiro de Técnico de Investigação
Center for Neuroscience and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2008/01/01 - 2012/06/20 Molecular mechanisms of synaptic traffic of glutamate receptors of NMDA type: implications in synaptic plasticity
SHFR/BD/37522/2007
PTDC/SAU-NEU/099440/2008
Bolseiro de Doutoramento
Center for Neuroscience and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2006/07/01 - 2007/12/31 Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors
POCI/SAU-NEU/58955/2004
Bolseiro de Técnico de Investigação
Center for Neuroscience and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2021/06/01 - 2023/05/31 Individual Call to Scientific Employment Stimulus - 3rd Edition (CEEC-IND)
2020.01761.CEECIND
Investigador responsável
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2020/06/30 The Nano-organization of NMDA receptors in neuronal cultures and brain tissue using super resolution techniques
ANR-15-CE16-0004-01
Bolseiro de Pós-Doutoramento
Institut Interdisciplinaire de Neurosciences, França

Centre National de la Recherche Scientifique, França

Université de Bordeaux, França
Agence nationale de la recherche
Em curso
2016/01/01 - 2016/12/31 Role of NMDA receptors co-agonists, glycine and D-serine in the regulation of NMDA receptor surface diffusion: implications in neuronal development
ANR-13-BSV4-0007
Bolseiro de Pós-Doutoramento
Institut Interdisciplinaire de Neurosciences, França
 Agence nationale de la recherche
Concluído
Produções

Publicações

Artigo em revista
  1. Inmaculada M. González-González; John A. Gray; Joana Ferreira; María Jose Conde-Dusman; Delphine Bouchet; Isabel Perez-Otaño; Laurent Groc. "GluN3A subunit tunes NMDA receptor synaptic trafficking and content during postnatal brain development". Cell Reports (2023): https://doi.org/10.1016/j.celrep.2023.112477.
    10.1016/j.celrep.2023.112477
  2. Paviolo, Chiara; Ferreira, Joana S.; Lee, Antony; Hunter, Daniel; Calaresu, Ivo; Nandi, Somen; Groc, Laurent; Cognet, Laurent. "Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses". Nano Letters 22 17 (2022): 6849-6856. http://dx.doi.org/10.1021/acs.nanolett.1c04259.
    10.1021/acs.nanolett.1c04259
  3. Joana S. Ferreira; Blanka Kellermayer; Ana Luísa Carvalho; Laurent Groc. "Interplay between NMDA receptor dynamics and the synaptic proteasome". European Journal of Neuroscience (2021): https://doi.org/10.1111/ejn.15427.
    10.1111/ejn.15427
  4. Tomohisa Hosokawa; Pin-Wu Liu; Qixu Cai; Joana S. Ferreira; Florian Levet; Corey Butler; Jean-Baptiste Sibarita; et al. "CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation". Nature Neuroscience 24 6 (2021): 777-785. https://doi.org/10.1038/s41593-021-00843-3.
    10.1038/s41593-021-00843-3
  5. Ferreira, Joana S. "A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue.". Advanced materials (Deerfield Beach, Fla.) (2021): https://doi.org/10.1002/adma.202006644.
    10.1002/adma.202006644
  6. Tomohisa Hosokawa; Pin-Wu Liu; Qixu Cai; Joana S. Ferreira; Florian Levet; Corey Butler; Jean-Baptiste Sibarita; et al. "CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase". Nature Neuroscience (2021): https://doi.org/10.1101/2020.11.25.397091.
    Aceite para publicação • 10.1101/2020.11.25.397091
  7. Amit Kumar Mandal; Xiaojian Wu; Joana S. Ferreira; Mijin Kim; Lyndsey R. Powell; Hyejin Kwon; Laurent Groc; YuHuang Wang; Laurent Cognet. "Fluorescent sp3 Defect-Tailored Carbon Nanotubes Enable NIR-II Single Particle Imaging in Live Brain Slices at Ultra-Low Excitation Doses". Scientific Reports 10 1 (2020): https://doi.org/10.1038/s41598-020-62201-w.
    Acesso aberto • 10.1038/s41598-020-62201-w
  8. Joana S. Ferreira; Julien P. Dupuis; Blanka Kellermayer; Nathan Bénac; Constance Manso; Delphine Bouchet; Florian Levet; et al. "Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites". Proceedings of the National Academy of Sciences (2020): https://doi.org/10.1073/pnas.1922477117.
    10.1073/pnas.1922477117
  9. Ferreira, Joana S. "Self-Interference (SELFI) Microscopy for Live Super-Resolution Imaging and Single Particle Tracking in 3D". (2019): http://dx.doi.org/10.3389/fphy.2019.00068.
    10.3389/fphy.2019.00068
  10. Ferreira, Joana S. "Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis". Methods (San Diego, Calif.) (2019): https://doi.org/10.1016/j.ymeth.2019.03.005.
    10.1016/j.ymeth.2019.03.005
  11. Ferreira, Joana. "Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses". Neuron (2018): https://doi.org/10.1016/j.neuron.2018.09.012.
    10.1016/j.neuron.2018.09.012
  12. Joana S Ferreira; Thomas Papouin; Laurent Ladépêche; Andrea Yao; Valentin C Langlais; Delphine Bouchet; Jérôme Dulong; et al. "Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses". eLife 6 (2017): https://doi.org/10.7554/eLife.25492.
    10.7554/eLife.25492
  13. Vieira MM; Schmidt J; Ferreira JS; She K; Oku S; Mele M; Santos AE; et al. "Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia.". (2016): http://europepmc.org/abstract/med/26581639.
    10.1016/j.nbd.2015.11.007
  14. Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos. "Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons". BIO-PROTOCOL 6 10 (2016): http://dx.doi.org/10.21769/bioprotoc.1807.
    10.21769/bioprotoc.1807
  15. Varela, J.A.; Ferreira, J.S.; Dupuis, J.P.; Durand, P.; Bouchet, D.; Groc, L.; Varela JA; et al. "Single nanoparticle tracking of N-methyl-D-aspartate receptors in cultured and intact brain tissue". Neurophotonics 3 4 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84991525161&partnerID=MN8TOARS.
    10.1117/1.NPh.3.4.041808]
  16. Ferreira, J. S.; Schmidt, J.; Rio, P.; Águas, R.; Rooyakkers, A.; Li, K. W.; Smit, A. B.; Craig, A. M.; Carvalho, A. L.. "GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome". J Neurosci 35 22 (2015): 8462-79.
    10.1523/JNEUROSCI.3567-14.2015
  17. She K; Ferreira JS; Carvalho AL; Craig AM. "Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.". (2012): http://europepmc.org/abstract/med/22740692.
    10.1074/jbc.M112.345108
  18. Santos SD; Iuliano O; Ribeiro L; Veran J; Ferreira JS; Rio P; Mulle C; Duarte CB; Carvalho AL. "Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors.". (2012): http://europepmc.org/abstract/med/22223644.
    10.1074/jbc.M111.322909
  19. Ferreira JS; Rooyakkers A; She K; Ribeiro L; Carvalho AL; Craig AM. "Activity and protein kinase C regulate synaptic accumulation of N-methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant.". (2011): http://europepmc.org/abstract/med/21676872.
    10.1074/jbc.M111.222539
  20. Gomes AR; Ferreira JS; Paternain AV; Lerma J; Duarte CB; Carvalho AL. "Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors.". (2008): http://europepmc.org/abstract/med/18065236.
    10.1016/j.mcn.2007.10.008
Capítulo de livro
  1. Ferreira, Joana S; Santos, S; Carvalho, AL. "Plasticidade Sináptica e Mecanismos de Memória". In Neurociências, editado por Rego, AC; Oliveira, CR; Duarte, CB. Portugal: LIDEL, 2017.
    Publicado
  2. Ferreira, Joana S; Comprido, D; Duarte, CB. "Transporte Axonal". In Neurociências, editado por Oliveira, CR; Rego, AC; Duarte, CB. Portugal: LIDEL, 2017.
    Publicado
Tese / Dissertação
  1. Ferreira, Joana S. "Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA type: Implications in Synaptic Plasticity". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2012. http://hdl.handle.net/10316/20286.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10/26 NMDA Receptors at the Nanoscale: Insights from Cultures to Brain Tissue. SPAOM 2023, Algarve, Portugal. SPAOM 2023
Universidade do Algarve (Faro, Portugal)
2023/05/04 Nanoscale organization in synapses and potential impact for cognitive resilience in aging. FENS Regional 2023, Algarve, Portugal. FENS Regional 2023
SPN (Faro, Portugal)
2023/04/12 A new trans-synaptic bridge formed by NMDA receptors and Neurexins. DCV.Talks, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. DCV talks
Department of Life Sciences, University of Coimbra (Coimbra, Portugal)
2021/07/06 Distance-dependent regulation of NMDAR nanoscale organization POST-TRANSLATIONAL MODIFICATIONS IN NEURONAL PHYSIOLOGY AND BRAIN DISORDERS
National Rechearch Council of Italy, Institute of Neuroscience (Milan, Itália)
2019/10/04 Receptors dynamics and nano-organization: new facets of NMDAR functions CNC Seminars
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2019/09/17 Receptors dynamics and nano-organization: new facets of NMDAR functions 17th Synapse Day Meeting
Bordeaux Neurocampus (Bordeaux, França)
2018 Investigating the brain extracellular space around synapses using single carbon nanotube tracking IINS 2018
Interdisciplinary Institute for Neuroscience (Bordeaux, França)
2017/05/16 Co-agonists tune NMDA receptor trafficking at developing synapses 15 e Journée du Club DRN (Development and Neuronal Networks)
(Bordeaux, França)
2017 Single nanoparticle tracking of neurotransmitter receptors in cultured and intact brain tissue FENS Regional Meeting 2017
(Pécs, Hungria)
2015 Co-agonist tunes GluN2B-NMDA receptor trafficking and content at developing hippocampal synapses GliSyn: Astrocytes and microglia, key partners in synaptic transmission
2nd International Bordeaux Neurocampus/Brain Conferences 2015 (Bordeaux, França)
2013/12/05 Molecular mechanisms of synaptic traffic of glutamate receptors of the NMDA type: implications in synaptic plasticity IINS seminars
Interdisciplinary Institute for Neuroscience (Bordeaux, França)
2013/06/30 Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors XIII Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurosciências (Luso, Portugal)
2013 Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors ENCODS European Neuroscience Conference by Doctoral Students, Juggling with Molecules, Circuits and Computation 2013
ENCODS (Bordeaux, França)
2012/09/02 Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors EMBO Pratical Course, Ubiquitin & Sumo
European Molecular Biology Organization (Sardinia, Itália)
2009/12/21 Molecular mechanisms of synaptic traffic of glutamate receptors of NMDA type: implications in synaptic plasticity VII CNC Annual Meeting
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2007/12/21 Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors V CNC Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/09 - 2023/09 ROLE OF GLUN2B-CONTAINING NMDARS ON NETWORK ACTIVITY AND SYNAPSE MATURATION AND ITS POTENTIAL INTERACTION WITH EPHA4
Orientador
 Biomedical Research Master Program (Mestrado)
Universidade de Coimbra, Portugal
2022/09 - 2023/09 NEUREXIN AND NMDAR NOVEL INTERACTION AND CO-DISTRIBUTION IN A DEVELOPMENTAL CONTEXT
Orientador
 Master in Molecular and Celular Biology (Mestrado)
Universidade de Coimbra, Portugal
2022/07 - 2023/03 Characterization of the new binding complex Neurexin2-GluN2B NMDAR
Orientador
 Applied Biology I, Bachelor in Biology (Licenciatura/Bacharelato)
Universidade de Coimbra, Portugal
2022/08 - 2022/08 The role of cell adhesion molecules in the regulation of synaptic function.
Orientador
 Summer with Science –I&D Unit CIBB (Iniciação científica)
Universidade de Aveiro, Portugal
2021/09/01 - 2022/02/28 Characterization of the new binding complex Neurexin2-GluN2B NMDAR
Orientador
 Student Mobility for Traineeships Eramus + (Iniciação científica)
Uniwersytet w Bialymstoku Instytut Biologii, Polónia
2021/08/01 - 2022/02/10 A New Trans-Synaptic Bridge: Characterization of the NMDAR-NRXN2 Complex
Orientador
 Applied Biology Project I (Licenciatura/Bacharelato)
Universidade de Coimbra, Portugal
2021/11/22 - 2021/12/17 Neurexin-2 and its potential interaction with NMDARs in schizophrenia
Orientador
 Molecular and Cellular Biology (Mestrado)
Universidade de Coimbra, Portugal
2019/01/01 - 2019/06/30 Role of GluN2 subunits on the binding of anti-NMDA receptor autoantibodies
Coorientador
 Neuroscience (Mestrado)
Université de Bordeaux Collège Sciences de la Santé, França
2018/01/01 - 2018/06/30 Manipulating the expression of CaMKII-a as a method of understanding NMDAR localization and function
Orientador
 Neuroscience (Mestrado)
Université de Bordeaux Collège Sciences de la Santé, França

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/06/15 - 2023/12/15 Organization of the Neuroscience meets society: transversal skills for future neuroscientists winter school, University of Coimbra, Portugal. (2023/12/11 - 2023/12/15)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2023/01/02 - 2023/06/06 Organization of the 5th CIBB Retreat Neuroscience & Disease, Miranda do Corvo, Portugal (2023/06/02 - 2023/06/02)
Encontro (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/05/03 - 2023/05/05 Organization of the symposium Nanoscale imaging to study the ageing brain at the FENS Regional Meeting, Algarve 2023. (2023/05/03 - 2023/05/05)
Simpósio (Membro da Comissão Organizadora)
 Federation of European Neuroscience Societies, Bélgica
2022/01/31 - 2022/02/04 Advanced Imaging - Advanced Courses 2021/2022, part of the Doctoral Program In Experimental Biology And Biomedicine [PDBEB]. (2022/01/31 - 2022/02/04)
Oficina (workshop) (Coorganizador)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/10/07 - 2018/10/10 Super-resolution microscopy in tissue: from myth to the bench! Fixation and staining optimization for imaging and 3D reconstruction. (2018/10/05 - 2018/10/12)
Oficina (workshop) (Coorganizador)
 Centre National de la Recherche Scientifique, França
2017/09/22 - 2017/09/22 Imaging the brain and cerebrospinal fluid at a single-molecule level. (2017/09/20 - 2017/09/22)
Simpósio (Coorganizador)
 Federation of European Neuroscience Societies, Bélgica

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/05/03 - Atual Invited for participation in the initiative iiiUC Trainings - Research Support Tools dedicated to the thematic Application to the CEEC Individual: Advice from successful candidates. University de Coimbra.
Institute of Interdisciplinary Research, Portugal
2023/02/11 - Atual Invited for participation in the initiative Women in Science, organized by the Juventude Socialista de São Pedro do Sul, Portugal.
Mesa-redonda
2022/04/22 - Atual VI meet.Lab Coimbra, Biology Students from the Academic Association of Coimbra (NEB/AAC), participation in round-table on the topic "What the future reserves: Academia versus Industry"
Mesa-redonda
 VI meet.Lab
Núcleo de Estudantes de Biologia - NEB, Portugal
2023/10/25 - 2023/10/27 Oral and Poster communication at SPAOM 2023, Faro, Algarve.
Congresso
 SPAOM 2023
Universidade do Algarve, Portugal
2023/09/29 - 2023/09/29 Participation in the Investigators European Night (NEI 2023) with Draw your Science activity.
Festival
 Investigators European Night (NEI 2023)
Universidade de Coimbra, Portugal
2022/10/20 - 2022/10/21 Poster presentation: NMDA receptors nanoarchitecture: an emerging regulator of glutamatergic synapses
Conferência
 VIII European Synapse Meeting ESM2022
Center for Neuroscience and Cell Biology, Portugal
2022/09/27 - 2022/09/30 Poster Presentation: NMDA receptors nanoarchitecture: an emerging regulator of glutamatergic synapses
Congresso
 MOLECULAR, CELLULAR AND NETWORK MECHANISMS OF SYNAPTIC PLASTICITY, 8th Bordeaux Neurocampus Conference
Institut Interdisciplinaire de Neurosciences, França
2021/12/01 - 2021/12/03 Poster Presentation: Distance-dependent regulation of NMDAR nanoscale organization.
Conferência
 XVII Meeting of the Portuguese Society for Neuroscience – SPN2021
Center for Neuroscience and Cell Biology, Portugal
2020 - 2021 Science Outreach Activities - http://neuro-extramuros.u-bordeaux.fr/Expo_IINS
Exposição
 SEMAINE DU CERVEAU
Institut Interdisciplinaire de Neurosciences, França
2018/06/20 - 2018/06/22 Pratical course on ImageJ macros automatization
Oficina (workshop)
 ImageJ macros automatization
Bordeaux Imaging Center, França
2017/10/15 - 2017/10/18 Poster Presentation: 3D super-resolution microscopy of GluN2A-and GluN2B-NMDA receptors subtypes in hippocampal neurons and High resolution investigation of the extracellular space around synapses in brain tissue by single carbon nanotube tracking
Encontro
 5th Frontiers in Neurophotonics FiNS 2017
Frontiers Neurophotonics Organization, Canadá
2016/04/01 - 2016/04/04 Poster presentation: Co-agonists tune GluN2B-NMDA receptor trafficking at developing hippocampal synapses.
Encontro
 7th ISN Special Neurochemistry Conference, Synaptic Function & Dysfunction in Brain Diseases 2016
International Society for Neurochemistry, Suiça
2014/07/05 - 2014/07/09 Poster presentation: GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome.
Congresso
 FENS Forum 2014
Federation of European Neuroscience Societies, Bélgica
2013/05/30 - 2013/06/01 Poster presentation: Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors
Encontro
 XIII Annual Meeting of the Portuguese Society for Neurosciences
Sociedade Portuguesa de Neurociências, Portugal
2012/09/01 - 2012/09/08 EMBO Practical Course on Ubiquitin and SUMO
Oficina (workshop)
 4th EMBO Practical Course Ubiquitin and SUMO 2012
European Molecular Biology Organization, Alemanha
2011/11/15 - 2011/11/19 Poster presentation: Homeostatic activity regulates synaptic accumulation of NMDA receptors independently of GluN1 splice variant.
Congresso
 SFN Neuroscience 2011
Society for Neuroscience, Estados Unidos
2011/09/18 - 2011/09/21 Poster presentation: Homeostatic activity regulates synaptic accumulation of NMDA receptors independently of GluN1 splice variant
Simpósio
 Champalimaud Neuroscience Symposium
Fundação Champalimaud, Portugal
2011/05/07 - 2011/05/10 Poster presentation: Role of GluN2B in the Synaptic Accumulation of NMDA Receptors
Oficina (workshop)
 CELL BIOLOGY OF THE NEURON: Polarity, Plasticity and Regeneration
European Molecular Biology Organization, Alemanha
2011/04/28 - 2011/04/30 Poster presentation: Homeostatic activity and PKC regulate synaptic accumulation of NMDA receptors independently of GluN1 splice variant
Encontro
 5th National Meeting on Cell Signalling
SINAL, Portugal
2010/12/01 - 2010/12/03 Pratical Course on Image Processing and Analysis in Cell Physiology
Oficina (workshop)
Universidade de Aveiro, Portugal
2010/10/11 - 2010/10/13 Poster presentation: NMDA receptor GluN1 splice variants undergo homeostatic activity-regulated synaptic accumulation.
Oficina (workshop)
 Cantoblanco Workshops on Biology: Memory Formation and Memory Loss 2010
Cantoblanco Workshops on Biology, Espanha
2010/05/06 - 2010/05/08 Poster presentation: Role of NR2B in the synaptic accumulation of NMDA receptors
Encontro
 ENI-net Final Meeting
Network of European Neuroscience Institutes, Alemanha
2010/01/27 - 2010/01/28 Pratical Course on Protein Identification by Mass Spectrometry
Oficina (workshop)
 1st RNEM Course on Protein Identification by Mass Spectrometry
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/09/23 - 2009/09/28 EMBO Course on Quantitative FRET, FRAP and FCS
Oficina (workshop)
 EMBO Pratical Course on Quantitative FRET, FRAP and FCS 2009
European Molecular Biology Organization, Alemanha
2009/09/02 - 2009/09/04 Pratical Course on Multifluorescence Microscopy
Oficina (workshop)
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/03/26 - 2008/03/28 Poster presentation: Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors.
Encontro
 1st European Synapse Meeting 2008
Fédération Bordeaux Neurocampus, França
2007/05/24 - 2007/05/26 Poster presentation: New truncated isoforms of AMPA receptor subunits generated by alternative splicing: characterization and functional relevance
Encontro
 X Meeting of the Portuguese Society for Neurosciences
Sociedade Portuguesa de Neurociências, Portugal
2006/12/08 - 2006/12/10 Poster presentation: Expression and Functional Relevance of Truncated Isoforms of AMPA Receptor Subunits Generated by Alternative Splicing
Congresso
 XVth National Congress of Biochemistry
Sociedade Portuguesa de Bioquímica, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/12/12 Differential regulation of GluN2A- and GluN2B-containing NMDA receptors by BDNF in the plasticity of hippocampal synapses
Arguente
 Pasqualino De Luca (Doutoramento)
Universidade de Coimbra, Portugal
2022/09/12 Deciphering the molecular mechanisms that mediate postsynaptic maturation
Arguente principal
 Maria Luísa Dias Pereira Félix Amado (Mestrado)
Universidade de Coimbra, Portugal
2022/02/25 Unraveling the role of P2Y1 receptor and CRMP2 in Aß-synaptotoxicity
Arguente principal
 Ana Sofia Carde Gregório Barata Figueira (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2023/08/31 - 2024/07/31 Frontiers in Psychiatry (Molecular Psychiatry)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2023 - Atual Peer-reviewer for the Agence Nationale de la Recherche (ANR) – French National Research Agency Agence Nationale de la Recherche (ANR), França
2020 - Atual Peer reviewer for Frontiers in Neuroscience.
Especialista
2022 - 2022 Peer reviewer for Frontiers in Synaptic Neuroscience.
2015 - 2020 Jury member in project evaluation of Bordeaux International Neuroscience Master 1 and 2, University of Bordeaux, France.
Avaliador
 Université de Bordeaux, França

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/11/01 - 2023/11/11 Advanced techniques for synapse biology, CAJAL Advanced Neuroscience Training Program, Bordeaux School of Neuroscience, France. Bordeaux School of Neuroscience, França
2023/10/18 - 2023/10/18 Lecture: Advanced imaging methods to decipher synapse function: a tale of glutamate receptors, PhD and Master Programs in Neurosciences, Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, coordinated by Ana M. Sebastião. Neurosciences (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Faculdade de Medicina, Portugal
2023/05/29 - 2023/05/29 Lecture: Nanoscale imaging tools in Neurosciences, PhD program EIT Health Ageing, from the European Institute of Innovation and Technology (EIT), course on Innovation and Entrepreneurship in Health, coordinated by João Malva (UC). Innovation and Entrepreneurship in Health (Curso de doutoramento (conclusão de unidades curriculares)) European Institute of Innovation and Technology (EIT), Hungria
2023/01/16 - 2023/01/20 Lecture: Post synaptic receptor function, Synapse assembly, function and plasticity, PDBEB, CNC, UC, coordinated by Ana Luísa Carvalho (UC). DOCTORAL PROGRAM IN EXPERIMENTAL BIOLOGY AND BIOMEDICINE [PDBEB] (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2022/12/20 - 2022/12/20 Seminário: Nano-organização de receptors NMDA - "Diz-me com quem andas dir-te-ei quem és", Licenciatura em Ciências Biomédicas, curso Neurobiologia, Universidade do Algarve, Portugal Neurobiologia (Licenciatura) Universidade do Algarve, Portugal
2022/05/24 - 2022/05/24 Lecture: Super-resolution microscopy: impact on Neurosciences, Advanced Imaging Methods in Neuroscience, PhD program EIT Health Ageing, from the European Institute of Innovation and Technology (EIT), course on Innovation and Entrepreneurship in Health, coordinated by João Malva (UC). Innovation and Entrepreneurship in Health European Institute of Innovation and Technology (EIT), Hungria
2022/02/10 - 2022/02/10 Lecture at Synapse Biology Advanced Course 2021/2022 part of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB), entitled: Nanoscale distribution of NMDA receptors: regulation and functional role. Synapse Biology (Curso de doutoramento (conclusão de unidades curriculares)) Center for Neuroscience and Cell Biology, Portugal

Universidade de Coimbra, Portugal
2021/11/09 - 2021/11/16 Neurobiologia Celular e Molecular - Glutamate Receptors Lectures, Project Evaluation & Problem Solving Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2021/04/05 - 2021/04/09 Lecture entitled "NMDA receptors dynamics and nanoscale organization: shaping synaptic plasticity", at NEURONAL CIRCUITS AND BEHAVIOR, CNC Advanced Courses 2021, Doctoral Program in Experimental Biology and Biomedicine (PDBEB) (Doutoramento) Universidade de Coimbra, Portugal
2015/10/10 - 2015/10/31 Advanced Techniques for Synapse Biology CAJAL Advanced Neuroscience Training Programme, França

Membro de associação

Nome da associação Tipo de participação
2017 - Atual International Society for Neurochemistry
2016 - Atual French Society for Neuroscience
2015 - Atual Society for Neuroscience
2014 - Atual European Molecular and Cellular Cognition Society
2007 - Atual Portuguese Society for Neuroscience
2006 - Atual Portuguese Biochemical Society

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2022/01/24 - Atual Thesis Commitee of Jorge Miguel Santos Castanheira, part of Ph.D. program in Health Sciences by NOVA Medical School, Universidade NOVA de Lisboa (NMS|FCM UNL).
Membro
 Universidade Nova de Lisboa, Portugal
2023/09/01 - 2027 Emanuel Tahiri, PhD program in Experimental Biology and Biomedicine from the University of Coimbra. Supervisors: Rui Costa (CNC-UC) and Carlos B. Duarte (CNC-UC, DCV, UC).
Membro
 Universidade de Coimbra, Portugal

Tutoria

Tópico Nome do aluno
2020/01/14 - 2020/03/16 Structural role of CaMKII in NMDA and AMPA glutamate receptors segregation Pinwu Liu
2018/10/26 - 2018/10/26 Super-resolution map of NMDA receptors in hippocampal neurons Maelle Guyoton; Matilde Bergamini
2017/11/17 - 2017/11/17 Single-nanoparticle tracking of glutamate receptors in developing hippocampal neurons Jenifer Rachel; Kjara Pilch
2014/09/01 - 2017/08/31 High-resolution imaging of the functional interplay between surface NMDA receptor and proteasome Blanka Kellermayer
2013/01/01 - 2015/08/31 Characterization of the novel Rho-GTPase activating protein, BPGAP1, in the central nervous system Jeannette Schmidt
2012/09/01 - 2013/06/30 The role of GluN2B-containing NMDA receptors in regulating the synaptic proteasome Rodolfo Águas
2010/09/01 - 2011/06/30 Molecular determinants of NMDA receptors synaptic delivery Pedro Rio
Distinções

Prémio

2022 Special recognition in Science
World Cultural Council, Suiça
2021 IBRO Return Home Fellowship
International Brain Research Organization, França
2021 Individual Call to Scientific Employment Stimulus (CEEC) - 3rd edition
Fundação para a Ciência e a Tecnologia, Portugal
2021 2021 BBRF Young Investigator Award
Brain & Behavior Research Foundation, Estados Unidos
2017 IBRO-FENS Regional Travel Grants Program
International Brain Research Organization, França

Federation of European Neuroscience Societies, Bélgica
2016 International Society for Neurochemistry Travel Grant
International Society for Neurochemistry, Suiça
2014 EMCCS and IBRO/PERC Travel Grant
European Molecular and Cellular Cognition Society, Alemanha

International Brain Research Organization, França
2014 IBRO International Travel Grant
International Brain Research Organization, França
2014 Portuguese Society for Neuroscience Travel Grant
Sociedade Portuguesa de Neurociências, Portugal
2012 EMBO Travel Grant
European Molecular Biology Organization, Alemanha
2011 Portuguese Biochemical Society Travel Grant
Sociedade Portuguesa de Bioquímica, Portugal
2009 EMBO Travel Grant
European Molecular Biology Organization, Alemanha
2008 European Commission, Eurosynapse Integrated Project Grant
European Commission, Bélgica
2005 Best 3% students
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Título

2022 Jeanne Marie Lee Investigator
Brain & Behavior Research Foundation, Estados Unidos

Outra distinção

2021 J Hell NewFinding Recomendation (https://facultyopinions.com/740018784)
F1000 Research Ltd, Reino Unido
2018 Hell J: F1000Prime Recommendation of [Kellermayer B et al., Neuron 2018 100(1):106-119.e7]
F1000 Research Ltd, Reino Unido
2016 Hardingham G: F1000Prime Recommendation of [Vieira MM et al., Neurobiol Dis 2016 89:223-234]
F1000 Research Ltd, Reino Unido