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Joana Ferreira graduated in Biology in 2006 from the University of Coimbra (UC) and completed her PhD in Biosciences, specialty Neurosciences (UC) in 2012, under the co-supervision of Ana Luísa Carvalho at the Center for Neuroscience and Cell Biology (CNC, Portugal) and Ann Marie Craig at the Center for Brain Health (University of British Columbia, Vancouver, Canada). After completing her PhD, she successfully obtained a postdoctoral fellowship to complete her studies on the molecular mechanisms of traffic of glutamate receptors at CNC. In 2016 she joined the group of Laurent Groc, at the Interdisciplinary Institute for Neuroscience (IINS, CNRS, University of Bordeaux, France), to explore the regulation of the nanoscale distribution of NMDA receptors (NMDARs). In 2021 she joined the CNC-UC as an Assistant Investigator, funded by the competitive scientific employment call of the Portuguese Foundation for Science and Technology (FCT) to start her independent line of research on the nanoscale architecture of the synapse, trans-synaptic signaling and its implications for neurological diseases. Recently, she was appointed the Principal Investigator (PI) position at the Multidisciplinary Institute of Ageing (MIA) to lead the Synapse Architecture in Brain Ageing group. She has extensive and recognized experience in molecular imaging of NMDARs and their interactors and a broad background in molecular neuroscience, with specific training in single-molecule localization super-resolution microscopy techniques. She has achieved a successful track record: 10 publications as first- or co-first-author in high-impact peer-review reference journals, including Neuron and PNAS, out of a total of 20 publications, 2 of them as co-corresponding-author. She has a large supervising experience (4 Master's thesis students; 2 scientific projects graduation students; 1 Erasmus+ Master’s student, 11 research internships, and 3 PhD laboratory work mentoring). She has participated twice as an instructor at the CAJAL Advanced Neuroscience Training Program in Bordeaux (2015 & 2023), as a lecturer in several advanced courses from the PhD Program in Experimental Biology and Biomedicine (PDBEB), and as a teacher in the Molecular Biology course from the Master Program of the University of Coimbra (UC) and the Neurobiology course from the Biomedical Sciences Graduation program from the University of Algarve. She was invited as the main opponent of 2 PhD and 2 MSc theses, as a jury member by the Bordeaux International Neuroscience Master Program and the Molecular Biology Master Program of the UC, and for 2 PhD thesis committees of Nova Lisbon University and UC. She has successfully organized 2 international symposiums (2017 and 2023 FENS Regional Meetings), a workshop at one of the biggest microscopy schools in Europe (MiFoBio 2018, France), and two advanced courses for PhD students (Advanced Imaging, 2022, PDBEB, UC and Neuroscience meets society: transversal skills for future neuroscientists). She is the PI of 2 international (IBRO Return Home Fellowship and 2021 Brain & Behavior Research Foundation Young Investigator Grant) and 1 national grant (FCT), co-PI in a consortium project funded by La Caixa Foundation Health Research 2020, and has participated in 8 funded research projects, >20 international scientific meetings, 8 of them as an invited speaker. In 2022 she received a Special Recognition in Science from the World Cultural Council (WCC) and the UC and was nominated as a Jeanne Marie Lee Investigator by the BBRF Research Partners Program.
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Identification

Personal identification

Full name
Joana Ferreira

Citation names

  • Ferreira, Joana S

Author identifiers

Ciência ID
0E15-84D6-0BF4
ORCID iD
0000-0002-1049-8063
Google Scholar ID
qiX9iFQAAAAJ
Scopus Author Id
36944021200

Email addresses

  • joanaferreira@cnc.uc.pt (Professional)
  • joana.s.ferreira@uc.pt (Professional)

Addresses

  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra (CNC-UC), Faculdade de Medicina, 2º piso, Rua Larga , 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Elementary (A2)
Education
Degree Classification
2008/01/01 - 2012/06/19
Concluded
 Biociências (Doutoramento)
Major in Neurociências
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Center for Neuroscience and Cell Biology, Portugal
"Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA type: Implications in Synaptic Plasticity" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2001/09/22 - 2006/06/20
Concluded
 Biology (Pre-Bolonha, 4 years) (Licenciatura)
Major in Scientific
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"N/A" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2021/06/01 - Current Auxiliary Researcher (Research) University of Coimbra, Portugal
Center for Neuroscience and Cell Biology, Portugal
2016/01/01 - 2021/05/15 Contracted Researcher (Research) Institut Interdisciplinaire de Neurosciences, France
Université de Bordeaux, France
(...)
2013/01/01 - 2015/12/31 Postdoc (Research) CNC.IBILI, Portugal
Universidade de Coimbra, Portugal
2013/09/04 - 2014/09/03 Visiting Researcher (Research) Institut Interdisciplinaire de Neurosciences, France
Centre National de la Recherche Scientifique, France
(...)
2012/01/01 - 2012/12/31 Research Assistant (Research) Center for Neuroscience and Cell Biology, Portugal
Universidade de Coimbra, Portugal
2008/01/01 - 2012/06/20 Research Trainee (Research) Center for Neuroscience and Cell Biology, Portugal
2008/05/01 - 2008/12/31 Visiting Researcher (Research) Djavad Mowafaghian Centre for Brain Health, Canada
The University of British Columbia Department of Medicine Division of Neurology, Canada
2006/07/01 - 2007/12/31 Research Assistant (Research) Center for Neuroscience and Cell Biology, Portugal
Universidade de Coimbra, Portugal
Projects

Grant

Designation Funders
2023/01/01 - 2026/12/31 Homeostatic plasticity defects in autism: insight from human mutations in the CNTNAP2 gene
607/C/2022
Researcher
La Fundació La Marató de TV3
Ongoing
2022/01/01 - 2024/12/31 The study of the novel NMDA receptor-Neurexin-2 interaction and potential role in schizophrenia
29902
Principal investigator
Universidade de Coimbra, Portugal
 Brain & Behavior Research Foundation
Ongoing
2023/03/01 - 2024/08/31 A New TransSynaptic Bridge: Functional characterization of the NMDA receptor-Neurexin interaction
2022.05386.PTDC
Principal investigator
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/09/15 - 2023/08/15 Potassium channel dysfunction in models of neurodevelopmental disorders
LCF/PR/HP20/52300003
Principal investigator
Institut Interdisciplinaire de Neurosciences, France
 ”la Caixa” Foundation
Ongoing
2021/06/01 - 2023/05/31 Functional characterization of a novel transsynaptic complex
IBRO Return Home Fellowship 2021
Principal investigator
Center for Neuroscience and Cell Biology, Portugal

Universidade de Coimbra, Portugal
International Brain Research Organization
Concluded
2013/01/01 - 2015/12/31 The Role of GluN2B-Containing NMDA Receptors in Regulating the Synaptic Proteasome: Implications to AMPA Receptor Traffic
SFRH/BPD/90045/2012
Post-doc Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/01/01 - 2012/12/31 Regulation of the stability of the messenger RNA for the GluR1 subunit of glutamate receptors
PTDC/BIA-BCM/113738/2009
Research Technician Fellow
Center for Neuroscience and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2012/06/20 Molecular mechanisms of synaptic traffic of glutamate receptors of NMDA type: implications in synaptic plasticity
SHFR/BD/37522/2007
PTDC/SAU-NEU/099440/2008
PhD Student Fellow
Center for Neuroscience and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006/07/01 - 2007/12/31 Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors
POCI/SAU-NEU/58955/2004
Research Technician Fellow
Center for Neuroscience and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/06/01 - 2023/05/31 Individual Call to Scientific Employment Stimulus - 3rd Edition (CEEC-IND)
2020.01761.CEECIND
Principal investigator
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/01 - 2020/06/30 The Nano-organization of NMDA receptors in neuronal cultures and brain tissue using super resolution techniques
ANR-15-CE16-0004-01
Post-doc Fellow
Institut Interdisciplinaire de Neurosciences, France

Centre National de la Recherche Scientifique, France

Université de Bordeaux, France
Agence nationale de la recherche
Concluded
2016/01/01 - 2016/12/31 Role of NMDA receptors co-agonists, glycine and D-serine in the regulation of NMDA receptor surface diffusion: implications in neuronal development
ANR-13-BSV4-0007
Post-doc Fellow
Institut Interdisciplinaire de Neurosciences, France
 Agence nationale de la recherche
Concluded
2010/09/15 - 2013/12/31 Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type
PTDC/SAU-NEU/099440/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2021/06/01 - 2024/12/31 Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. "Surface Glutamate Receptor Nanoscale Organization with Super-Resolution Microscopy (dSTORM)". In New Technologies for Glutamate Interaction: Neurons and Glia. United States: Humana New York, NY, 2024.
    Submitted • https://doi.org/10.1007/978-1-0716-3742-5_2
  2. Ferreira, Joana S; Santos, S; Carvalho, AL. "Plasticidade Sináptica e Mecanismos de Memória". In Neurociências, edited by Rego, AC; Oliveira, CR; Duarte, CB. Portugal: LIDEL, 2017.
    Published
  3. Ferreira, Joana S; Comprido, D; Duarte, CB. "Transporte Axonal". In Neurociências, edited by Oliveira, CR; Rego, AC; Duarte, CB. Portugal: LIDEL, 2017.
    Published
Conference poster
  1. Cação, Carlos; Ferreira, Constança; João Gonçalves Martins; Ferreira, Joana S. Corresponding author: Ferreira, Joana S. "Cell-adhesion proteins interplay with NMDA Receptors: implication for synaptic nanoarchitecture". Paper presented in European Synapse Meeting ESM2024, 2024.
  2. João Gonçalves Martins; Ferreira, Constança; Ana Luísa Monteiro Carvalho; Ferreira, Joana S. Corresponding author: Ferreira, Joana S. "Role of GluN2B-containing NMDARs on network activity and synapse maturation and its potential interaction with EphA4". Paper presented in AIMS Meeting – Annual International (bio) Medical Students Meeting, 2024.
  3. Ferreira, Joana S. "NMDA Receptors at the Nanoscale: Insights from Cultures to Brain Tissue". Paper presented in SPAOM 2023, 2023.
  4. Ferreira, Joana S. "NMDA receptors nanoarchitecture: an emerging regulator of glutamatergic synapses". Paper presented in VIII European Synapse Meeting ESM2022, 2022.
  5. Ferreira, Joana S. "NMDA receptors nanoarchitecture: an emerging regulator of glutamatergic synapses". Paper presented in MOLECULAR, CELLULAR AND NETWORK MECHANISMS OF SYNAPTIC PLASTICITY, 8th Bordeaux Neurocampus Conference, 2022.
  6. Schmidt, Jeannette; Inácio, Ângela S.; Ferreira, Joana S; Socodato, Renato; Relvas, Joao B; Pinheiro, Paulo César da Silva; Carvalho, Ana Luisa. "The Rho GTPase Activating Protein ARHGAP8 Controls Spine Maturation and AMPA Receptor Traffic". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  7. Ferreira, Joana S. "Distance dependent regulation of NMDAR nanoscale organization". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience SPN2021, 2021.
  8. Schmidt, Jeannette; Santos, Inês Baião; Ferreira, Joana S; Socodato, Renato; Relvas, João B.; Pinheiro, Paulo; Carvalho, Ana Luisa. "ARHGAP8 Regulates Excitatory Synapses". Paper presented in 8th EMCCS-FENS, 2018.
  9. Schmidt, Jeannette; Santos, Inês Baião; Ferreira, Joana S; Socodato, Renato; Relvas, João B.; Pinheiro, Paulo; Carvalho, Ana Luisa. "ARHGAP8 Regulates Excitatory Synapse Function". Paper presented in 11th FENS Forum of Neuroscience, 2018.
  10. Ferreira, Joana S. "Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses". Paper presented in FENS Regional Meeting (FRM 2017), 2017.
  11. Ferreira, Joana S. "3D super-resolution microscopy of GluN2A-and GluN2B-NMDA receptors subtypes in hippocampal neurons". Paper presented in Frontiers in Neurophotonics international symposium (FiNs 2017), 2017.
  12. Ferreira, Joana S. "Co-agonists differentially tune GluN2B-NMDA Receptor trafficking at hippocampal synapses". Paper presented in NeuroFrance 2017 - Biennial Meeting of the French Neuroscience Society, 2017.
  13. Schmidt, Jeannette; Ferreira, Joana S; Socodato, Renato; Relvas, João B.; Duarte, Carlos B.; Carvalho, Ana Luisa. "Role of ARHGAP8, a novel Rho GAP, in Regulating Excitatory Synapses". Paper presented in SfN - Neuroscience 2016, 2016.
  14. Ferreira, Joana S. "Co-agonists tune GluN2B-NMDA receptor trafficking at developing hippocampal synapses". Paper presented in Synaptic Function & Dysfunction in Brain Diseases - 7th ISN Special Neurochemistry Conference, 2016.
  15. Ferreira, Joana S. "Co-agonist differential role in NMDA receptors subunit composition in hippocampal synapses". Paper presented in IINS-BIC retreat 2015, 2015.
  16. Ferreira, Joana S. "GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome". Paper presented in FENS Forum 2014 and 6th EMCCS-FENS satellite meeting, 2014.
  17. Ferreira, Joana S. "Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors". Paper presented in XIII Annual meeting SPN, 2013.
  18. Ferreira, Joana S. "Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors". Paper presented in EMBO Practical Course on Ubiquitin & Sumo, 2012.
  19. Ferreira, Joana S. "Homeostatic activity and PKC regulate synaptic accumulation of NMDA receptors independently of GluN1 splice variant". Paper presented in SINAL 2011, 2011.
  20. Ferreira, Joana S. "Role of GluN2B in the Synaptic Accumulation of NMDA Receptors". Paper presented in EMBO workshop: Cell Biology of the Neuron: Polarity, Plasticity and Regeneration, 2011.
  21. Ferreira, Joana S. "Homeostatic activity regulates synaptic accumulation of NMDA receptors independently of GluN1 splice variant". Paper presented in Champalimaud Neuroscience Symposium, 2011.
  22. Ferreira, Joana S. ": Homoeostatic activity and PKC regulate synaptic accumulation of NMDA receptors independently of GluN1 splice variant". Paper presented in SFN meeting: Neuroscience 2011, 2011.
  23. Ferreira, Joana S. "Role of NR2B in the synaptic accumulation of NMDA receptors". Paper presented in ENI-net final meeting, 2010.
  24. Ferreira, Joana S. "NMDA receptor GluN1 splice variants undergo homeostatic activity-regulated synaptic accumulation". Paper presented in Cantoblanco Workshops on Biology: Memory Formation and Memory Loss, 2010.
  25. Ferreira, Joana S. "Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors". Paper presented in 1st European Synapse Meeting, 2008.
  26. Ferreira, Joana S. "New truncated isoforms of AMPA receptor subunits generated by alternative splicing: characterization and functional relevance". Paper presented in 10th Meeting SPN, 2007.
  27. Ferreira, Joana S. "Expression and Functional Relevance of Truncated Isoforms of AMPA Receptor Subunits Generated by Alternative Splicing". Paper presented in XV National Meeting of Biochemistry, 2006.
  28. Ferreira, Joana S. "Expression and Functional Relevance of Truncated Isoforms of AMPA Receptor Subunits Generated by Alternative Splicing". Paper presented in Expression and Functional Relevance of Truncated Isoforms of AMPA Receptor Subunits Generated by Alternative Splicing, 2006.
Journal article
  1. Schmidt, Jeannette; Inácio, Ângela; Ferreira, Joana S; Serrenho, Débora; Socodato, Renato; Beltrão, Nuno; Ribeiro, Luís F; et al. "[PREPRINT] Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission". bioRxiv (2024):
    Submitted • 10.1101/2024.02.29.582472
  2. Inmaculada M. González-González; John A. Gray; Joana Ferreira; María Jose Conde-Dusman; Delphine Bouchet; Isabel Perez-Otaño; Laurent Groc. "GluN3A subunit tunes NMDA receptor synaptic trafficking and content during postnatal brain development". Cell Reports (2023): https://doi.org/10.1016/j.celrep.2023.112477.
    10.1016/j.celrep.2023.112477
  3. Paviolo, Chiara; Ferreira, Joana S.; Lee, Antony; Hunter, Daniel; Calaresu, Ivo; Nandi, Somen; Groc, Laurent; Cognet, Laurent. "Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses". Nano Letters 22 17 (2022): 6849-6856. http://dx.doi.org/10.1021/acs.nanolett.1c04259.
    10.1021/acs.nanolett.1c04259
  4. Joana S. Ferreira; Blanka Kellermayer; Ana Luísa Carvalho; Laurent Groc. "Interplay between NMDA receptor dynamics and the synaptic proteasome". European Journal of Neuroscience (2021): https://doi.org/10.1111/ejn.15427.
    10.1111/ejn.15427
  5. Tomohisa Hosokawa; Pin-Wu Liu; Qixu Cai; Joana S. Ferreira; Florian Levet; Corey Butler; Jean-Baptiste Sibarita; et al. "CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation". Nature Neuroscience 24 6 (2021): 777-785. https://doi.org/10.1038/s41593-021-00843-3.
    10.1038/s41593-021-00843-3
  6. Ferreira, Joana S. "A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue.". Advanced materials (Deerfield Beach, Fla.) (2021): https://doi.org/10.1002/adma.202006644.
    10.1002/adma.202006644
  7. Tomohisa Hosokawa; Pin-Wu Liu; Qixu Cai; Joana S. Ferreira; Florian Levet; Corey Butler; Jean-Baptiste Sibarita; et al. "CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase". Nature Neuroscience (2021): https://doi.org/10.1101/2020.11.25.397091.
    Accepted • 10.1101/2020.11.25.397091
  8. Amit Kumar Mandal; Xiaojian Wu; Joana S. Ferreira; Mijin Kim; Lyndsey R. Powell; Hyejin Kwon; Laurent Groc; YuHuang Wang; Laurent Cognet. "Fluorescent sp3 Defect-Tailored Carbon Nanotubes Enable NIR-II Single Particle Imaging in Live Brain Slices at Ultra-Low Excitation Doses". Scientific Reports 10 1 (2020): https://doi.org/10.1038/s41598-020-62201-w.
    Open access • 10.1038/s41598-020-62201-w
  9. Joana S. Ferreira; Julien P. Dupuis; Blanka Kellermayer; Nathan Bénac; Constance Manso; Delphine Bouchet; Florian Levet; et al. "Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites". Proceedings of the National Academy of Sciences (2020): https://doi.org/10.1073/pnas.1922477117.
    10.1073/pnas.1922477117
  10. Ferreira, Joana S. "Self-Interference (SELFI) Microscopy for Live Super-Resolution Imaging and Single Particle Tracking in 3D". (2019): http://dx.doi.org/10.3389/fphy.2019.00068.
    10.3389/fphy.2019.00068
  11. Ferreira, Joana S. "Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis". Methods (San Diego, Calif.) (2019): https://doi.org/10.1016/j.ymeth.2019.03.005.
    10.1016/j.ymeth.2019.03.005
  12. Ferreira, Joana. "Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses". Neuron (2018): https://doi.org/10.1016/j.neuron.2018.09.012.
    10.1016/j.neuron.2018.09.012
  13. Joana S Ferreira; Thomas Papouin; Laurent Ladépêche; Andrea Yao; Valentin C Langlais; Delphine Bouchet; Jérôme Dulong; et al. "Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses". eLife 6 (2017): https://doi.org/10.7554/eLife.25492.
    10.7554/eLife.25492
  14. Vieira MM; Schmidt J; Ferreira JS; She K; Oku S; Mele M; Santos AE; et al. "Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia.". (2016): http://europepmc.org/abstract/med/26581639.
    10.1016/j.nbd.2015.11.007
  15. Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos. "Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons". BIO-PROTOCOL 6 10 (2016): http://dx.doi.org/10.21769/bioprotoc.1807.
    10.21769/bioprotoc.1807
  16. Varela, J.A.; Ferreira, J.S.; Dupuis, J.P.; Durand, P.; Bouchet, D.; Groc, L.; Varela JA; et al. "Single nanoparticle tracking of N-methyl-D-aspartate receptors in cultured and intact brain tissue". Neurophotonics 3 4 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84991525161&partnerID=MN8TOARS.
    10.1117/1.NPh.3.4.041808]
  17. Ferreira, J. S.; Schmidt, J.; Rio, P.; Águas, R.; Rooyakkers, A.; Li, K. W.; Smit, A. B.; Craig, A. M.; Carvalho, A. L.. "GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome". J Neurosci 35 22 (2015): 8462-79.
    10.1523/JNEUROSCI.3567-14.2015
  18. She K; Ferreira JS; Carvalho AL; Craig AM. "Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.". (2012): http://europepmc.org/abstract/med/22740692.
    10.1074/jbc.M112.345108
  19. Santos SD; Iuliano O; Ribeiro L; Veran J; Ferreira JS; Rio P; Mulle C; Duarte CB; Carvalho AL. "Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors.". (2012): http://europepmc.org/abstract/med/22223644.
    10.1074/jbc.M111.322909
  20. Ferreira JS; Rooyakkers A; She K; Ribeiro L; Carvalho AL; Craig AM. "Activity and protein kinase C regulate synaptic accumulation of N-methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant.". (2011): http://europepmc.org/abstract/med/21676872.
    10.1074/jbc.M111.222539
  21. Gomes AR; Ferreira JS; Paternain AV; Lerma J; Duarte CB; Carvalho AL. "Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors.". (2008): http://europepmc.org/abstract/med/18065236.
    10.1016/j.mcn.2007.10.008
Online resource
  1. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. Advanced Fluorescent Microscopy for Neurosciences. 2024.
    10.5281/zenodo.10621197.
  2. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. Advanced imaging methods to decipher synapse function: a tale of glutamate receptors. 2023.
    10.5281/zenodo.10024211
  3. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. Nanoscale imaging tools in Neurosciences. 2023.
    10.5281/zenodo.7986912
  4. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. Super-resolution microscopy: applied to Neuroscience Research. 2022.
    10.5281/zenodo.7371696
  5. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. Super resolution microscopy: impact on Neurosciences. 2022.
    10.5281/zenodo.7371653
  6. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. Glutamatergic Synapses and Glutamate Receptors. 2022.
    10.5281/zenodo.7371631
  7. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. INTRODUCTION TO SUPER RESOLUTION MICROSCOPY. 2022.
    10.5281/zenodo.7371579.
  8. Ferreira, Joana S. Corresponding author: Ferreira, Joana S. SINGLE MOLECULE TRACKING: FROM CULTURES TO SLICES. 2022.
    10.5281/zenodo.7371540
Thesis / Dissertation
  1. Ferreira, Joana S. "Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA type: Implications in Synaptic Plasticity". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2012. http://hdl.handle.net/10316/20286.
Working paper
  1. Ventura Rodrigues, Marina; Inácio, Ângela S.; Virginia Soldovieri, Maria; Bauberg, Théo; Leal, Telmo; Ribau, Sara; Amado, Luísa; et al. 2024. "Type I TARPs are auxiliary proteins of Kv7.2-M-channels".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/30 Lecture: Post-synaptic receptor function Synapse assembly, function and plasticity Course of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB)
CNC-Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2024/01/29 Lecture: Advanced fluorescence microscopy for Neurosciences Synapse assembly, function and plasticity Course of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB)
CNC-Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2023/10/26 NMDA Receptors at the Nanoscale: Insights from Cultures to Brain Tissue. SPAOM 2023, Algarve, Portugal. SPAOM 2023
Universidade do Algarve (Faro, Portugal)
2023/05/04 Nanoscale organization in synapses and potential impact for cognitive resilience in aging. FENS Regional 2023, Algarve, Portugal. FENS Regional 2023
SPN (Faro, Portugal)
2023/04/12 A new trans-synaptic bridge formed by NMDA receptors and Neurexins. DCV.Talks, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. DCV talks
Department of Life Sciences, University of Coimbra (Coimbra, Portugal)
2021/07/06 Distance-dependent regulation of NMDAR nanoscale organization POST-TRANSLATIONAL MODIFICATIONS IN NEURONAL PHYSIOLOGY AND BRAIN DISORDERS
National Rechearch Council of Italy, Institute of Neuroscience (Milan, Italy)
2019/10/04 Receptors dynamics and nano-organization: new facets of NMDAR functions CNC Seminars
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2019/09/17 Receptors dynamics and nano-organization: new facets of NMDAR functions 17th Synapse Day Meeting
Bordeaux Neurocampus (Bordeaux, France)
2018 Investigating the brain extracellular space around synapses using single carbon nanotube tracking IINS 2018
Interdisciplinary Institute for Neuroscience (Bordeaux, France)
2017/05/16 Co-agonists tune NMDA receptor trafficking at developing synapses 15 e Journée du Club DRN (Development and Neuronal Networks)
(Bordeaux, France)
2017 Single nanoparticle tracking of neurotransmitter receptors in cultured and intact brain tissue FENS Regional Meeting 2017
(Pécs, Hungary)
2015 Co-agonist tunes GluN2B-NMDA receptor trafficking and content at developing hippocampal synapses GliSyn: Astrocytes and microglia, key partners in synaptic transmission
2nd International Bordeaux Neurocampus/Brain Conferences 2015 (Bordeaux, France)
2013/12/05 Molecular mechanisms of synaptic traffic of glutamate receptors of the NMDA type: implications in synaptic plasticity IINS seminars
Interdisciplinary Institute for Neuroscience (Bordeaux, France)
2013/06/30 Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors XIII Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurosciências (Luso, Portugal)
2013 Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors ENCODS European Neuroscience Conference by Doctoral Students, Juggling with Molecules, Circuits and Computation 2013
ENCODS (Bordeaux, France)
2012/09/02 Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors EMBO Pratical Course, Ubiquitin & Sumo
European Molecular Biology Organization (Sardinia, Italy)
2009/12/21 Molecular mechanisms of synaptic traffic of glutamate receptors of NMDA type: implications in synaptic plasticity VII CNC Annual Meeting
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2007/12/21 Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors V CNC Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02/12 - 2024/06/30 Exploration of the new interactions between NMDAR and CAMs
Supervisor
 Master's degree on Cellular and Molecular Biology (Neurobiology specialization) (Degree)
Universidad Autónoma de Madrid, Spain
2024/01/29 - 2024/02/23 Interplay between NMDARs and Neurexins
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2022/09 - 2023/09 ROLE OF GLUN2B-CONTAINING NMDARS ON NETWORK ACTIVITY AND SYNAPSE MATURATION AND ITS POTENTIAL INTERACTION WITH EPHA4
Supervisor
 Biomedical Research Master Program (Master)
Universidade de Coimbra, Portugal
2022/09 - 2023/09 NEUREXIN AND NMDAR NOVEL INTERACTION AND CO-DISTRIBUTION IN A DEVELOPMENTAL CONTEXT
Supervisor
 Master in Molecular and Celular Biology (Master)
Universidade de Coimbra, Portugal
2022/07 - 2023/03 Characterization of the new binding complex Neurexin2-GluN2B NMDAR
Supervisor
 Applied Biology I, Bachelor in Biology (Degree)
Universidade de Coimbra, Portugal
2022/08 - 2022/08 The role of cell adhesion molecules in the regulation of synaptic function.
Supervisor
 Summer with Science –I&D Unit CIBB (Scientific initiation)
Universidade de Aveiro, Portugal
2021/09/01 - 2022/02/28 Characterization of the new binding complex Neurexin2-GluN2B NMDAR
Supervisor
 Student Mobility for Traineeships Eramus + (Scientific initiation)
Uniwersytet w Bialymstoku Instytut Biologii, Poland
2021/08/01 - 2022/02/10 A New Trans-Synaptic Bridge: Characterization of the NMDAR-NRXN2 Complex
Supervisor
 Applied Biology Project I (Degree)
Universidade de Coimbra, Portugal
2021/11/22 - 2021/12/17 Neurexin-2 and its potential interaction with NMDARs in schizophrenia
Supervisor
 Molecular and Cellular Biology (Master)
Universidade de Coimbra, Portugal
2019/01/01 - 2019/06/30 Role of GluN2 subunits on the binding of anti-NMDA receptor autoantibodies
Co-supervisor
 Neuroscience (Master)
Université de Bordeaux Collège Sciences de la Santé, France
2018/01/01 - 2018/06/30 Manipulating the expression of CaMKII-a as a method of understanding NMDAR localization and function
Supervisor
 Neuroscience (Master)
Université de Bordeaux Collège Sciences de la Santé, France

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/01/29 - 2024/02/02 Bruker Microscopes Demonstration: Vutara VXL – Single-Molecule Localization Microscope and SPIM light-sheet microscopes (2024/01/29 - 2024/02/02)
Workshop
2023/06/15 - 2023/12/15 Organization of the Neuroscience meets society: transversal skills for future neuroscientists winter school, University of Coimbra, Portugal. (2023/12/11 - 2023/12/15)
Workshop (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2023/01/02 - 2023/06/06 Organization of the 5th CIBB Retreat Neuroscience & Disease, Miranda do Corvo, Portugal (2023/06/02 - 2023/06/02)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/05/03 - 2023/05/05 Organization of the symposium Nanoscale imaging to study the ageing brain at the FENS Regional Meeting, Algarve 2023. (2023/05/03 - 2023/05/05)
Symposium (Member of the Organising Committee)
 Federation of European Neuroscience Societies, Belgium
2022/01/31 - 2022/02/04 Advanced Imaging - Advanced Courses 2021/2022, part of the Doctoral Program In Experimental Biology And Biomedicine [PDBEB]. (2022/01/31 - 2022/02/04)
Workshop (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/10/07 - 2018/10/10 Super-resolution microscopy in tissue: from myth to the bench! Fixation and staining optimization for imaging and 3D reconstruction. (2018/10/05 - 2018/10/12)
Workshop (Co-organisor)
 Centre National de la Recherche Scientifique, France
2017/09/22 - 2017/09/22 Imaging the brain and cerebrospinal fluid at a single-molecule level. (2017/09/20 - 2017/09/22)
Symposium (Co-organisor)
 Federation of European Neuroscience Societies, Belgium

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/05/03 - Current Invited for participation in the initiative iiiUC Trainings - Research Support Tools dedicated to the thematic Application to the CEEC Individual: Advice from successful candidates. University de Coimbra.
Round table
Institute of Interdisciplinary Research, Portugal
2023/02/11 - Current Invited for participation in the initiative Women in Science, organized by the Juventude Socialista de São Pedro do Sul, Portugal.
Round table
2022/04/22 - Current VI meet.Lab Coimbra, Biology Students from the Academic Association of Coimbra (NEB/AAC), participation in round-table on the topic "What the future reserves: Academia versus Industry"
Round table
 VI meet.Lab
Núcleo de Estudantes de Biologia - NEB, Portugal
2023/09/29 - 2023/09/29 Participation in the Investigators European Night (NEI 2023) with Draw your Science activity.
Festival
 Investigators European Night (NEI 2023)
Universidade de Coimbra, Portugal
2020 - 2021 Science Outreach Activities - http://neuro-extramuros.u-bordeaux.fr/Expo_IINS
Exhibition
 SEMAINE DU CERVEAU
Institut Interdisciplinaire de Neurosciences, France
2018/06/20 - 2018/06/22 Pratical course on ImageJ macros automatization
Workshop
 ImageJ macros automatization
Bordeaux Imaging Center, France
2012/09/01 - 2012/09/08 EMBO Practical Course on Ubiquitin and SUMO
Workshop
 4th EMBO Practical Course Ubiquitin and SUMO 2012
European Molecular Biology Organization, Germany
2010/12/01 - 2010/12/03 Pratical Course on Image Processing and Analysis in Cell Physiology
Workshop
Universidade de Aveiro, Portugal
2010/01/27 - 2010/01/28 Pratical Course on Protein Identification by Mass Spectrometry
Workshop
 1st RNEM Course on Protein Identification by Mass Spectrometry
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/09/23 - 2009/09/28 EMBO Course on Quantitative FRET, FRAP and FCS
Workshop
 EMBO Pratical Course on Quantitative FRET, FRAP and FCS 2009
European Molecular Biology Organization, Germany
2009/09/02 - 2009/09/04 Pratical Course on Multifluorescence Microscopy
Workshop
Universidade de Coimbra Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/01/26 Blocking ATP Signaling and ROS Generation Preserves Neurogenesis and Network Activity In Epileptogenesis In Hippocampal Organotypic Slice Culture
(Thesis) Main arguer
 ANE BODERO RODRIGUEZ (PhD)
Universidad del País Vasco, Spain
2023/10/23 ROLE OF GLUN2B-CONTAINING NMDARS ON NETWORK ACTIVITY AND SYNAPSE MATURATION THROUGH THE INTERACTION WITH EPHA4
Supervisor
 JOÃO MARTINS (Master)
Universidade de Coimbra, Portugal
2023/09/26 Neurexin and NMDAR novel interaction and co-distribution in a developmental context
Supervisor
 CONSTANÇA FERREIRA (Master)
Universidade de Coimbra, Portugal
2022/12/12 Differential regulation of GluN2A- and GluN2B-containing NMDA receptors by BDNF in the plasticity of hippocampal synapses
(Thesis) Arguer
 Pasqualino De Luca (PhD)
Universidade de Coimbra, Portugal
2022/09/12 Deciphering the molecular mechanisms that mediate postsynaptic maturation
(Thesis) Main arguer
 Maria Luísa Dias Pereira Félix Amado (Master)
Universidade de Coimbra, Portugal
2022/02/25 Unraveling the role of P2Y1 receptor and CRMP2 in Aß-synaptotoxicity
(Thesis) Main arguer
 Ana Sofia Carde Gregório Barata Figueira (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - Current Molecular Psychiatry
2023/01/23 - Current Cell Reports

Association member

Society Organization name Role
2024 - Current ALBA Network Member
2017 - Current International Society for Neurochemistry
2016 - Current French Society for Neuroscience
2015 - Current Society for Neuroscience
2014 - Current European Molecular and Cellular Cognition Society
2007 - Current Portuguese Society for Neuroscience
2006 - Current Portuguese Biochemical Society

Committee member

Activity description
Role 		Institution / Organization
2022/01/24 - Current Thesis Commitee of Jorge Miguel Santos Castanheira, part of Ph.D. program in Health Sciences by NOVA Medical School, Universidade NOVA de Lisboa (NMS|FCM UNL).
Member
 Universidade Nova de Lisboa, Portugal
2023/09/01 - 2027 Emanuel Tahiri, PhD program in Experimental Biology and Biomedicine from the University of Coimbra. Supervisors: Rui Costa (CNC-UC) and Carlos B. Duarte (CNC-UC, DCV, UC).
Member
 Universidade de Coimbra, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09 - 2024/02 Neurobiologia Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2023/11/01 - 2023/11/11 Advanced techniques for synapse biology, CAJAL Advanced Neuroscience Training Program, Bordeaux School of Neuroscience, France. Bordeaux School of Neuroscience, France
2023/10/18 - 2023/10/18 Lecture: Advanced imaging methods to decipher synapse function: a tale of glutamate receptors, PhD and Master Programs in Neurosciences, Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, coordinated by Ana M. Sebastião. Neurosciences (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Faculdade de Medicina, Portugal
2023/05/29 - 2023/05/29 Lecture: Nanoscale imaging tools in Neurosciences, PhD program EIT Health Ageing, from the European Institute of Innovation and Technology (EIT), course on Innovation and Entrepreneurship in Health, coordinated by João Malva (UC). Innovation and Entrepreneurship in Health (Curso de doutoramento (conclusão de unidades curriculares)) European Institute of Innovation and Technology (EIT), Hungary
2023/01/16 - 2023/01/20 Lecture: Post synaptic receptor function, Synapse assembly, function and plasticity, PDBEB, CNC, UC, coordinated by Ana Luísa Carvalho (UC). DOCTORAL PROGRAM IN EXPERIMENTAL BIOLOGY AND BIOMEDICINE [PDBEB] (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2022/12/20 - 2022/12/20 Seminário: Nano-organização de receptors NMDA - "Diz-me com quem andas dir-te-ei quem és", Licenciatura em Ciências Biomédicas, curso Neurobiologia, Universidade do Algarve, Portugal Neurobiologia (Licenciatura) Universidade do Algarve, Portugal
2022/05/24 - 2022/05/24 Lecture: Super-resolution microscopy: impact on Neurosciences, Advanced Imaging Methods in Neuroscience, PhD program EIT Health Ageing, from the European Institute of Innovation and Technology (EIT), course on Innovation and Entrepreneurship in Health, coordinated by João Malva (UC). Innovation and Entrepreneurship in Health European Institute of Innovation and Technology (EIT), Hungary
2022/02/10 - 2022/02/10 Lecture at Synapse Biology Advanced Course 2021/2022 part of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB), entitled: Nanoscale distribution of NMDA receptors: regulation and functional role. Synapse Biology (Curso de doutoramento (conclusão de unidades curriculares)) Center for Neuroscience and Cell Biology, Portugal

Universidade de Coimbra, Portugal
2021/11/09 - 2021/11/16 Neurobiologia Celular e Molecular - Glutamate Receptors Lectures, Project Evaluation & Problem Solving Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2021/04/05 - 2021/04/09 Lecture entitled "NMDA receptors dynamics and nanoscale organization: shaping synaptic plasticity", at NEURONAL CIRCUITS AND BEHAVIOR, CNC Advanced Courses 2021, Doctoral Program in Experimental Biology and Biomedicine (PDBEB) (Doutoramento) Universidade de Coimbra, Portugal
2015/10/10 - 2015/10/31 Advanced Techniques for Synapse Biology CAJAL Advanced Neuroscience Training Programme, France

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023 - Current Peer-reviewer for the Agence Nationale de la Recherche (ANR) – French National Research Agency Agence Nationale de la Recherche (ANR), France
2015 - 2020 Jury member in project evaluation of Bordeaux International Neuroscience Master 1 and 2, University of Bordeaux, France.
Evaluator
 Université de Bordeaux, France

Journal scientific committee

Journal title (ISSN) Publisher
2023/08/31 - Current Frontiers in Psychiatry (Molecular Psychiatry)
2022 - Current Frontiers in Synaptic Neuroscience
2020 - Current Frontiers in Neuroscience

Mentoring / Tutoring

Topic Student name
2020/01/14 - 2020/03/16 Structural role of CaMKII in NMDA and AMPA glutamate receptors segregation Pinwu Liu
2018/10/26 - 2018/10/26 Super-resolution map of NMDA receptors in hippocampal neurons Maelle Guyoton; Matilde Bergamini
2017/11/17 - 2017/11/17 Single-nanoparticle tracking of glutamate receptors in developing hippocampal neurons Jenifer Rachel; Kjara Pilch
2014/09/01 - 2017/08/31 High-resolution imaging of the functional interplay between surface NMDA receptor and proteasome Blanka Kellermayer
2013/01/01 - 2015/08/31 Characterization of the novel Rho-GTPase activating protein, BPGAP1, in the central nervous system Jeannette Schmidt
2012/09/01 - 2013/06/30 The role of GluN2B-containing NMDA receptors in regulating the synaptic proteasome Rodolfo Águas
2010/09/01 - 2011/06/30 Molecular determinants of NMDA receptors synaptic delivery Pedro Rio
Distinctions

Award

2022 Special recognition in Science
World Cultural Council, Switzerland
2021 IBRO Return Home Fellowship
International Brain Research Organization, France
2021 Individual Call to Scientific Employment Stimulus (CEEC) - 3rd edition
Fundação para a Ciência e a Tecnologia, Portugal
2021 2021 BBRF Young Investigator Award
Brain & Behavior Research Foundation, United States
2017 IBRO-FENS Regional Travel Grants Program
International Brain Research Organization, France

Federation of European Neuroscience Societies, Belgium
2016 International Society for Neurochemistry Travel Grant
International Society for Neurochemistry, Switzerland
2014 EMCCS and IBRO/PERC Travel Grant
European Molecular and Cellular Cognition Society, Germany

International Brain Research Organization, France
2014 IBRO International Travel Grant
International Brain Research Organization, France
2014 Portuguese Society for Neuroscience Travel Grant
Sociedade Portuguesa de Neurociências, Portugal
2012 EMBO Travel Grant
European Molecular Biology Organization, Germany
2011 Portuguese Biochemical Society Travel Grant
Sociedade Portuguesa de Bioquímica, Portugal
2009 EMBO Travel Grant
European Molecular Biology Organization, Germany
2008 European Commission, Eurosynapse Integrated Project Grant
European Commission, Belgium
2005 Best 3% students
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Title

2022 Jeanne Marie Lee Investigator
Brain & Behavior Research Foundation, United States

Other distinction

2021 J Hell NewFinding Recomendation (https://facultyopinions.com/740018784)
F1000 Research Ltd, United Kingdom
2018 Hell J: F1000Prime Recommendation of [Kellermayer B et al., Neuron 2018 100(1):106-119.e7]
F1000 Research Ltd, United Kingdom
2016 Hardingham G: F1000Prime Recommendation of [Vieira MM et al., Neurobiol Dis 2016 89:223-234]
F1000 Research Ltd, United Kingdom