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Identificação

Identificação pessoal

Nome completo
Tatiana Barros Reis Cereija

Nomes de citação

  • Cereija, T.B.

Identificadores de autor

Ciência ID
0D1B-2EB5-80B8
ORCID iD
0000-0002-7176-0205
Scopus Author Id
55199843100

Endereços de correio eletrónico

  • tatiana.cereija@i3s.up.pt (Profissional)

Moradas

  • i3S, Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)
Formação
Grau Classificação
2018/06/29
Concluído
 Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Biochemical and structural characterization of novel mycobacterial drug targets " (TESE/DISSERTAÇÃO)
 Approved
Produções

Publicações

Artigo em revista
  1. Monteiro, R.; Cereija, T.B.; Pombinho, R.; Voskuilen, T.; Codée, J.D.C.; Sousa, S.; Morais-Cabral, J.H.; Cabanes, D.. "Molecular properties of the RmlT wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes". Nature Communications 16 1 (2025): https://doi.org/10.1038/s41467-024-55360-1.
    Publicado • 10.1038/s41467-024-55360-1
  2. Rocha, R.; Jorge, J.M.P.; Teixeira-Duarte, C.M.; Figueiredo-Costa, I.R.; Cereija, T.B.; Ferreira-Teixeira, P.F.; Herzberg, C. ; Stülke, J. ; Morais-Cabral, J.H.. "c-di-AMP determines the hierarchical organization of bacterial RCK proteins". PNAS (2024): https://doi.org/10.1073/pnas.2318666121.
    Publicado • 10.1073/pnas.2318666121
  3. Cereija, T.B.; Guerra, J.P.L.; Jorge, J.M.P.; Morais-Cabral, J.H.. "c-di-AMP, a likely master regulator of bacterial K+ homeostasis machinery, activates a K+ exporter". Proceedings of the National Academy of Sciences of the United States of America 118 14 (2021): e2020653118. https://doi.org/10.1073/pnas.2020653118.
    Publicado • 10.1073/pnas.2020653118
  4. Cereija, T.B.; Alarico, S.; Lourenço, E.C.; Manso, J.A.; Ventura, M.R.; Empadinhas, N.; Macedo-Ribeiro, S.; Pereira, P.J.B.. "The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation". IUCrJ 6 4 (2019): 572-585. https://doi.org/10.1107/S2052252519005372.
    Publicado • 10.1107/s2052252519005372
  5. Cereija, T.B.; Alarico, S.; Empadinhas, N.; Pereira, P.J.B.. "Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase". Acta Crystallographica Section F Structural Biology Communications 73 9 (2017): 536-540. https://doi.org/10.1107/S2053230X17012419.
    Publicado • 10.1107/S2053230X17012419
  6. Machado, A.; Castro, J.; Cereija, T.; Almeida, C.; Cerca, N.. "Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescence in situ hybridization method". PeerJ 2015 2 (2015): https://doi.org/10.7717/peerj.780.
    10.7717/peerj.780
  7. Castro, J.; Alves, P.; Sousa, C.; Cereija, T.; França, Â.; Jefferson, K.K.; Cerca, N.. "Using an in-vitro biofilm model to assess the virulence potential of Bacterial Vaginosis or non-Bacterial Vaginosis Gardnerella vaginalis isolates". Scientific Reports 5 (2015): https://doi.org/10.1038/srep11640.
    10.1038/srep11640
  8. Silva, D.; Henriques, A.; Cereija, T.; Martinez-De-Oliveira, J.; Miranda, M.; Cerca, N.. "Prevalence of Gardnerella vaginalis and Atopobium vaginae in Portuguese women and association with risk factors for bacterial vaginosis". International Journal of Gynecology and Obstetrics 124 2 (2014): 178-179. https://doi.org/10.1016/j.ijgo.2013.08.008.
    10.1016/j.ijgo.2013.08.008
  9. Alves, P.; Castro, J.; Sousa, C.; Cereija, T.B.; Cerca, N.. "Gardnerella vaginalis Outcompetes 29 other bacterial species isolated from patients with bacterial vaginosis, using in an in vitro biofilm formation model". Journal of Infectious Diseases 210 4 (2014): 593-596. https://doi.org/10.1093/infdis/jiu131.
    10.1093/infdis/jiu131
  10. Cereija, T.B.; Castro, J.; Alves, P.; Cerca, N.. "Influence of anaerobic conditions on vaginal microbiota recovery from bacterial vaginosis patients". Sexually Transmitted Infections 89 4 (2013): https://doi.org/10.1136/sextrans-2013-051100.
    10.1136/sextrans-2013-051100
  11. Figueiredo, A.C.; De Sanctis, D.; Gutiérrez-Gallego, R.; Cereija, T.B.; Macedo-Ribeiro, S.; Fuentes-Prior, P.; Pereira, P.J.B.. "Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector". Proceedings of the National Academy of Sciences of the United States of America 109 52 (2012): https://doi.org/10.1073/pnas.1211614109.
    Publicado • 10.1073/pnas.1211614109
  12. Henriques, A.; Cereija, T.; Machado, A.; Cerca, N.. "In silico vs in vitro analysis of primer specificity for the detection of Gardnerella vaginalis, Atopobium vaginae and Lactobacillus spp". BMC Research Notes 5 (2012): https://doi.org/10.1186/1756-0500-5-637.
    10.1186/1756-0500-5-637
  13. Cereija, T.B.; Figueiredo, A.C.; De Sanctis, D.; Tanaka, A.S.; Pereira, P.J.B.. "Crystallization and preliminary crystallographic characterization of the N-terminal Kunitz domain of boophilin". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 68 4 (2012): 436-439. https://doi.org/10.1107/S1744309112005532.
    10.1107/S1744309112005532
  14. Freitas, S.C.; Cereija, T.B.; Figueiredo, A.C.; Osório, H.; Pereira, P.J.B.; Barbosa, M.A.; Martins, M.C.L.. "Bioengineered surfaces to improve the blood compatibility of biomaterials through direct thrombin inactivation". Acta Biomaterialia 8 11 (2012): 4101-4110. https://doi.org/10.1016/j.actbio.2012.07.020.
    10.1016/j.actbio.2012.07.020
Capítulo de livro
  1. Felgueiras, C.; Cereija, T.B.; Machado, A.; Cerca, N.; Rodrigues, L.R.. "Lactobacilli and its Metabolites as Potential Probiotics against Gardnerella vaginalis". In Industrial, medical and environmental applications of microorganisms Current status and trends, 541-545. Wageningen, Países Baixos: Wageningen Academic Publishers, 2014.
    Publicado
Poster em conferência
  1. Monteiro, R.; Cereija, T.B.; Pombinho, R.; Sousa, S.; Morais-Cabral, J.H.; Cabanes, D.. "Dissecting the Role of RmlT in Listeria monocytogenes: from structural analysis to in vivo infection implications". Trabalho apresentado em 21st International Symposium on Problems of Listeria and Listeriosis (ISOPOL), 2024.
  2. Cereija, T.B.; Morais-Cabral, J.H.. "Ligand regulated CPA K+/H+ antiporter". Trabalho apresentado em INSTRUCT cryo-EM workshop on sample preparation for Single Particle Analysis (Grenoble, France), 2023.
  3. Cereija, T.B.; Guerra, J.P.L.,; Morais-Cabral, J.H.. "Atypical RCK domain present in a two component K+/H+ antiporter". Trabalho apresentado em 63rd Annual Meeting of the Biophysical Society (Baltimore, Maryland, USA), 2019.
  4. Monteiro, R.; Meireles, D.; Cereija, T.B.; Pombinho, A.; Morais-Cabral, J.H.; Sousa, S.; Cabanes, D.. "Shaping the activity of Listeria monocytogenes rhamnosyltransferase RmlT as an auspicious antivirulence strategy.". Trabalho apresentado em 8th I3S Annual Meeting (Póvoa de Varzim, Portugal), 2019.
  5. Cereija, T.B.; Alarico, S.; Lourenço, E.C.; Ventura, M.R.; Empadinhas, N.; Pereira, P.J.B.. "Biochemical and structural characterization of a mycobacterial glucosylglycerate hydrolase, a key enzyme in nitrogen starvation recovery". Trabalho apresentado em XIX National Congress of Biochemistry (Guimarães, Portugal), 2016.
  6. Cereija, T.B.; Lourenço, E.C.; Ventura, M.R.; Empadinhas, N.; Pereira, P.J.B.. "Structural characterization of a mycobacterial glucosylglycerate hydrolase, a key enzyme in nitrogen starvation recovery". Trabalho apresentado em 5th I3S Annual Meeting (Póvoa de Varzim, Portugal), 2016.
  7. Ferreira, C.; Salvador, A. F.; Cereija, T.B.; Cerca, N.; Sousa, D.. "Comparison of vaginal microbiota fingerprints from healthy and bacterial vaginosis-positive portuguese women". Trabalho apresentado em MicroBiotec 2013 (Aveiro, Portugal), 2013.
  8. Cereija, T.B.; Machado, A.; Felgueiras, C.; Cerca, N.; Rodrigues, L. R.. "Lactobacilli and its metabolites as potential probiotics against Gardnerella vaginalis". Trabalho apresentado em BioMicroWorld 2013 - V International Conference on Environmental, Industrial and Applied Microbiology (Madrid, Spain)., 2013.
  9. Alves, P.; Castro, J.; Sousa, C.; Cereija, T.B.; Cerca, N.. "Gardnerella vaginalis virulence potential outcompetes with 30 other microorganisms isolated from BV patients". Trabalho apresentado em Eurobiofilms 2013 (Ghent, Belgium), 2013.
  10. Castro, J.; Alves, P.; Sousa, C.; Cereija, T.B.; Cerca, N.. "Isolation of Gardnerella vaginalis from BV patients and healthy women : analysis of virulence through adherence, biofilm formation and cytotoxicity assays". Trabalho apresentado em Eurobiofilms 2013 (Ghent, Belgium), 2013.
  11. Alves, P.; Castro, J.; Cereija, T.B.; Henriques, A.; Cerca, N.. "Characterization of biofilm-forming microorganisms isolated from vaginal exudate in Portugal". Trabalho apresentado em Biofilms 5 (Paris, France), 2012.
  12. Freitas, S.C.; Cereija, T.B.; Figueiredo, A.C.; Pereira, P.J.B.; Barbosa, M.A.; Martins, M.C.L.. "Bioengineered surfaces for direct thrombin inactivation to improve their hemocompatibility". Trabalho apresentado em 2nd I3S Scientific Retreat (Póvoa de Varzim, Portugal), 2011.
  13. Cereija, T.B.; Figueiredo, A.C.; Macedo-Ribeiro, S.; Fuentes-Prior, P.; Tanaka, A.S.; Pereira, P.J.B.. "Boophilin: one inhibitor and two inhibition mechanisms". Trabalho apresentado em XVII National Congress of Biochemistry (Porto, Portugal), 2010.
    10.18638/scieconf.2016.4.1.375
Pré-impressão
  1. Monteiro, R.; Cereija, T.B.; Pombinho, R.; Sousa, S.; Morais-Cabral, J.H.; Cabanes, D.. "Molecular properties of RmlT, a wall teichoic acid rhamnosyltransferase that modulates Listeria monocytogenes virulence and antibiotic resistance". 2024.
    10.1101/2024.01.23.574818
Recurso online
  1. Cereija, T.B.; Morais-Cabral, J.H.. Crystal structure of the L. monocytogenes RmlT in complex with 4-RboP-(CH2)6NH2 (PDB ID: 9GZK). 2024. https://www.rcsb.org/structure/9GZK.
    https://doi.org/10.2210/pdb9GZK/pdb
  2. Cereija, T.B.; Morais-Cabral, J.H.. Crystal structure of the L. monocytogenes RmlT in complex with 3-RboP-(CH2)6NH2 (PDB ID: 9GZJ). 2024. https://www.rcsb.org/structure/9GZJ.
    https://doi.org/10.2210/pdb9GZJ/pdb
  3. Cereija, T.B.; Teixeira-Duarte, C.M.; Morais-Cabral, J.H.. Low resolution structure of inactive conformation of the Ktr cation channel in presence of ATP and c-di-AMP (PDB ID: 8POO). 2023. https://www.rcsb.org/structure/8POO.
    https://doi.org/10.2210/pdb8POO/pdb
  4. Cereija, T.B.; Morais-Cabral, J.H.. Crystal structure of the apo form of the L. monocytogenes RmlT (PDB ID: 8BZ4). 2022. https://www.rcsb.org/structure/8BZ4.
    https://doi.org/10.2210/pdb8BZ4/pdb
  5. Cereija, T.B.; Morais-Cabral, J.H.. Crystal structure of the L. monocytogenes RmlT in complex with HEPES (PDB ID: 8BZ5). 2022. https://www.rcsb.org/structure/8BZ5.
    https://doi.org/10.2210/pdb8BZ5/pdb
  6. Cereija, T.B.; Morais-Cabral, J.H.. Crystal structure of the L. monocytogenes RmlT in complex with UDP-glucose (PDB ID: 8BZ6). 2022. https://www.rcsb.org/structure/8BZ6.
    https://doi.org/10.2210/pdb8BZ6/pdb
  7. Cereija, T.B.; Morais-Cabral, J.H.. Crystal structure of the L. monocytogenes RmlT in complex with TDP-rhamnose (PBD ID: 8BZ7). 2022. https://www.rcsb.org/structure/8BZ7.
    https://doi.org/10.2210/pdb8BZ7/pdb
  8. Cereija, T.B.; Morais-Cabral, J.H.. Crystal structure of the L. monocytogenes RmlT D198A variant in complex with TDP-rhamnose (PDB ID: 8BZ8). 2022. https://www.rcsb.org/structure/8BZ8.
    https://doi.org/10.2210/pdb8BZ8/pdb
  9. Cereija, T.B.; Morais-Cabral, J.H.. Structure of the N-domain of the K+/H+ antiporter subunit KhtT at pH 7.5 (PDB ID: 7AHT). 2020. https://www.rcsb.org/structure/7AHT.
    https://doi.org/10.2210/pdb7AHT/pdb
  10. Cereija, T.B.; Guerra, J.P.; Morais-Cabral, J.H.. Low-resolution structure of the K+/H+ antiporter subunit KhtT in complex with c-di-AMP (PDB ID: 7AHM). 2020. https://www.rcsb.org/structure/7AHM.
    https://doi.org/10.2210/pdb7AHM/pdb
  11. Cereija, T.B.; Guerra, J.P.; Morais-Cabral, J.H.. High-resolution structure of the K+/H+ antiporter subunit KhtT in complex with c-di-AMP (PDB ID: 7AGV). 2020. https://www.rcsb.org/structure/7AGV.
    https://doi.org/10.2210/pdb7AGV/pdb
  12. Cereija, T.B.; Morais-Cabral, J.H.. Structure of the N-domain of the K+/H+ antiporter subunit KhtT at pH 6.5 (PDB ID: 7AGW). 2020. https://www.rcsb.org/structure/7AGW.
    https://doi.org/10.2210/pdb7AGW/pdb
  13. Cereija, T.B.; Morais-Cabral, J.H.. Structure of the N-domain of the K+/H+ antiporter subunit KhtT at pH 8.5 (PDB ID: 7AGY). 2020. https://www.rcsb.org/structure/7AGY.
    https://doi.org/10.2210/pdb7AGY/pdb
  14. Cereija, T.B.; Vilela, F.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Mycobacterial hydrolase 1 (PDB ID: 6S2Q). 2019. https://www.rcsb.org/structure/6S2Q.
    https://doi.org/10.2210/pdb6S2Q/pdb
  15. Cereija, T.B.; Vilela, F.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Mycobacterial hydrolase 2 (PDB ID: 6S2R). 2019. https://www.rcsb.org/structure/6S2R.
    https://doi.org/10.2210/pdb6S2R/pdb
  16. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Mycobacterial hydrolase complex 14 (PDB ID: 6G3N). 2018. https://www.rcsb.org/structure/6G3N.
    https://doi.org/10.2210/pdb6G3N/pdb
  17. Figueiredo, A.C.; de Sanctis, D.; Gutierrez-Gallego, R.; Cereija, T.B.; Macedo-Ribeiro, S.; Fuentes-Prior, P.; Pereira, P.J.B.. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism (PDB ID: 4E05). 2012. https://www.rcsb.org/structure/4E05.
    https://doi.org/10.2210/pdb4E05/pdb
  18. Figueiredo, A.C.; de Sanctis, D.; Gutierrez-Gallego, R.; Cereija, T.B.; Macedo-Ribeiro, S.; Fuentes-Prior, P.; Pereira, P.J.B.. Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism (PDB ID: 4E06). 2012. https://www.rcsb.org/structure/4E06.
    https://doi.org/10.2210/pdb4E06/pdb
Tese / Dissertação
  1. Cereija, TB; Cereija, T. "Biochemical and structural characterization of novel mycobacterial drug targets". Doutoramento, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2018.
  2. Cereija, TB; Cereija, T. "Characterization of trypsin inhibition by boophilin". Mestrado, Universidade de Aveiro, 2010.

Outros

Conjunto de dados
  1. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) - apo form. 2019.
  2. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) E419A variant in complex with glucosylglycolate. 2018.
  3. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) D182A variant in complex with glucosylglycolate. 2018.
  4. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase(MhGgH) E419A variant in complex with glucosylglycerol. 2018.
  5. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) E419A variant in complex with mannosylglycerate. 2018.
  6. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) E419A variant in complex with glucosylglycerate. 2018.
  7. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) D182A variant in complex with mannosylglycerate. 2018.
  8. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) D182A variant in complex with glucosylglycerate. 2018.
  9. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) D43A variant in complex with serine and glycerol. 2018.
  10. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) E419A variant in complex with serine and glycerol. 2018.
  11. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) D182A variant in complex with serine and glycerol. 2018.
  12. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) in complex with serine and glycerol. 2018.
  13. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) - SeMet derivative. 2018.
  14. Cereija, T.B.; Macedo-Ribeiro, S.; Pereira, P.J.B.. Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) in complex with glycerol. 2018.
Atividades

Arbitragem científica em conferência

Nome da conferência Local da conferência
2020 - 2020 3rd PhDay | Back to the Future Universidade do Porto Instituto de Investigação e Inovação em Saúde
Distinções

Prémio

2022 Prémio Jovem Biofísico SPBf 2022
Sociedade Portuguesa de Biofísica, Portugal
2022 EMBO Scientific Exchange Grant
European Molecular Biology Organization (EMBO), Alemanha
2021 Concurso Estímulo ao Emprego Científico Individual (CEEC)
Fundação para a Ciência e a Tecnologia, Portugal
2013 FCT Individual PhD studentship
Fundação para a Ciência e a Tecnologia, Portugal