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Stefanie Lopes dos Santos. Completed the Mestrado in Laboratorial and Clinical Biology in 2014 by Universidade de Trás-os-Montes e Alto Douro, Licenciatura in Biochemistry in 2012 by Universidade de Trás-os-Montes e Alto Douro and Doktor (PhD) in Pharmaceutical Sciences in 2020 by Universität Basel. Is Researcher in Universidade de Trás-os-Montes e Alto Douro. Published 7 articles in journals. Has received 1 awards and/or honors. Participates and/or participated as Research Fellow in 1 project(s) and Researcher in 1 project(s).
Identificação

Identificação pessoal

Nome completo
Stefanie Lopes dos Santos

Nomes de citação

  • Santos, Stefanie

Identificadores de autor

Ciência ID
0A1F-1BA1-8CF3
ORCID iD
0000-0002-2020-6538
Google Scholar ID
https://scholar.google.com/citations?user=E2kJeSkAAAAJ&
Researcher Id
MBG-4027-2025
Scopus Author Id
57207833709

Endereços de correio eletrónico

  • stefsantos.01@hotmail.com (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Naturais - Ciências Biológicas - Métodos de Investigação Bioquímica
  • Ciências Naturais - Ciências Biológicas - Fitologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2016 - 2020
Concluído
 Pharmaceutical Sciences (Doktor (PhD))
Universität Basel, Suiça
"Pharmaceutical Research on Bryophyllum pinnatum" (TESE/DISSERTAÇÃO)
 05/06
2014/07 - 2014/07
Concluído
 Infectious and parasitic diseases (Outros)
Universidade de Trás-os-Montes e Alto Douro, Portugal
 18/20
2011 - 2014
Concluído
 Laboratorial and Clinical Biology (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Apoptotic Potencial of copper: in vitro study. Expression of caspases 3, 8 and 9, AIF and protein p53" (TESE/DISSERTAÇÃO)
 19/20
2005 - 2012
Concluído
 Biochemistry (Bachelor)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Evaluation of the expression of adherent molecules during lung development. Mechanisms involved in the respiratory syndrome of premature infants" (TESE/DISSERTAÇÃO)
 19/20
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/09/01 - 2025/12/31 Researcher Universidade de Trás-os-Montes e Alto Douro, Portugal
Universidade de Trás-os-Montes e Alto Douro, Portugal
2024/05/15 - 2024/08/31 Research Fellow (Project BE@T com a Referência nº BI/UTAD/21/2024) Universidade de Trás-os-Montes e Alto Douro, Portugal
Universidade de Trás-os-Montes e Alto Douro, Portugal
2023/10/01 - 2023/12/15 Laboratory Technician Cosmetek, Portugal
2016/09 - 2020/08 PhD student UniversitätsSpital Zürich Klinik für Gynäkologie, Suiça
2016/06/01 - 2016/08/31 Research Trainee UniversitätsSpital Zürich, Suiça
Projetos

Projeto

Designação Financiadores
2024/09/01 - 2025/12/31 ANSWER - SustAiNable Safe WinERies: Identification and mapping of microorganisms and their susceptibility to UVC radiation - new approach to develop robots for winery disinfection
C644866286-00000011
Investigador
I&D Vine&Wine Portugal Driving Sustainable Growth Through Smart Innovation, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2024/07/15 - 2024/08/31 BE@T – Bioeconomy for Textiles and Clothing to Reinforce the National Bioeconomy, Textile and Clothing Sector
BI/UTAD/21/2024
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Zurfluh, Leonie; Santos, Stefanie; Ruppen, Annina; Mosbacher, Johannes; Haslinger, Christian; Ochsenbein-Kölble, Nicole; Potterat, Olivier; Simões-Wüst, Ana Paula. "Bryophyllum pinnatum modulation of signaling pathways relevant for preterm labor in human myometrial cells". Biomedicine & Pharmacotherapy 184 (2025): 117919. https://doi.org/10.1016/j.biopha.2025.117919.
    Publicado • 10.1016/j.biopha.2025.117919
  2. Santos, Stefanie; Zurfluh, L.; Mennet, M.; Potterat, O.; von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Corrigendum: Bryophyllum pinnatum compounds inhibit oxytocin-induced signaling pathways in human myometrial cells". Frontiers in Pharmacology 14 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85148603150&partnerID=MN8TOARS.
    10.3389/fphar.2023.1141346
  3. Santos, S.; Zurfluh, L.; Mennet, M.; Potterat, O.; von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Bryophyllum pinnatum Compounds Inhibit Oxytocin-Induced Signaling Pathways in Human Myometrial Cells". Frontiers in Pharmacology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102148393&partnerID=MN8TOARS.
    10.3389/fphar.2021.632986
  4. Santos, S.; Haslinger, C.; Klaic, K.; Faleschini, M.T.; Mennet, M.; Potterat, O.; Von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility in Vitro". Planta Medica 85 5 (2019): 385-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062947790&partnerID=MN8TOARS.
    10.1055/a-0810-7704
  5. Santos, S.; Haslinger, C.; Mennet, M.; Von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: An in vitro study". BMC Complementary and Alternative Medicine 19 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074545700&partnerID=MN8TOARS.
    10.1186/s12906-019-2711-5
  6. Füeg, F.; Santos, S.; Haslinger, C.; Stoiber, B.; Schäffer, L.; Grünblatt, E.; Zimmermann, R.; Simões-Wüst, A.P.. "Influence of oxytocin receptor single nucleotide sequence variants on contractility of human myometrium: An in vitro functional study". BMC Medical Genetics 20 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075044407&partnerID=MN8TOARS.
    10.1186/s12881-019-0894-8
  7. Santos, S.; Silva, A.M.; Matos, M.; Monteiro, S.M.; Álvaro, A.R.. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53". Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 185-186 (2016): 138-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963665511&partnerID=MN8TOARS.
    10.1016/j.cbpc.2016.03.010
  8. Santos, S; Carvalho, R; Pinto, M; Coelho, A C; Gonçalves, C; Bairos, V. "Expression of E-Cadherin and Beta-Catenin in the Developing Lung after Prenatal Administration of Vitamin A". Pediatric Research 70 (2011): 544-544. https://doi.org/10.1038/pr.2011.769.
    10.1038/pr.2011.769
Poster em conferência
  1. Santos, Stefanie; Zurfluh, Leonie; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula ; Simões-Wust, Ana Paula; Hamburger, Matthias. Autor correspondente: Zurfluh, Leonie. "Bryophyllum pinnatum attenuates oxytocin-induced pro-inflammatory signalling pathways in human myometrial cells". Trabalho apresentado em SGGG (Swiss Society of Gynaecology and Obstetrics), Geneva, Switzerland, 2023.
  2. Zurfluh, Leonie; Santos, Stefanie; Haslinger, Christian; Mennet, Monica; von Mandach, Ursula; Potterat, Olivier; Simões-Wust, Ana Paula. "Bryphyllum pinnatum prevents Prostaglandin F2alpha-induced contractility of human myometrium in vitro". Trabalho apresentado em SGGG (Swiss Society of Gynaecology and Obstetrics), Geneva, Switzerland, 2022.
  3. Santos, Stefanie; Zurfluh, Leonie; Mennet, Monica; von Mandach, Ursula; Potterat, Olivier; Hamburger, Matthias; Simões-Wust, Ana Paula. Autor correspondente: Zurfluh, Leonie. "Bryophyllum pinnatum compounds inhibit oxytocin-induced signalling pathways in human myometrial cells". Trabalho apresentado em Tetranational Congress: Phytotherapy, Zurich, Switzerland, 2022.
  4. Santos, Stefanie; Zurfluh, Leonie; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit oxytocin-induced signalling pathways in human myometrial cells". Trabalho apresentado em 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Virtual-meeting, 2021.
  5. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Trabalho apresentado em 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Innsbruck, Austria, 2019.
  6. Santos, Stefanie; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "Bryophyllum pinnatum fractions inhibit the oxytocin-induced increase of intracellular calcium concentration in human myometrial cells". Trabalho apresentado em 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Innsbruck, Austria, 2019.
  7. Santos, Stefanie; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit the oxytocin-induced rise of intracellular calcium concentration in human myometrial cells". Trabalho apresentado em 12th Swiss Pharma Science Day, Bern, Switzerland, 2019.
  8. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Trabalho apresentado em SGGG (Swiss Society of Gynaecology and Obstetrics), Saint Gallen, Switzerland, 2019.
  9. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Trabalho apresentado em 11th Swiss Pharma Science Day, Bern, Switzerland, 2018.
  10. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Trabalho apresentado em 22nd International Congress Phytopharm, Wädenswil, Switzerland, 2018.
  11. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursular; Simões-Wust, Ana Paula. "Bryophyllum pinnatum press juice enhances the tocolytic effect of nifedipine on in vitro myometrium contractility". Trabalho apresentado em SGGG (Swiss Society of Gynaecology and Obstetrics), Interlaken, Switzerland, 2018.
  12. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect on myometrium contractility of a combination of Bryophyllum pinnatum juice and atosiban". Trabalho apresentado em 65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Basel, Switzerland, 2017.
  13. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect on myometrial contractility of a combination of Bryophyllum pinnatum press juice and nifedipine". Trabalho apresentado em 10th Swiss Pharma Science Day, Bern, Switzerland, 2017.
  14. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect on myometrial contractility of a combination of Bryophyllum pinnatum press juice and atosiban". Trabalho apresentado em 10th Swiss Pharma Science Day, Bern, Switzerland, 2017.
  15. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect of Bryophyllum pinnatum press juice combined with atosiban on myometrium contractility". Trabalho apresentado em SGGG (Swiss Society of Gynaecology and Obstetrics), Lausanne, Switzerland, 2017.
  16. Santos, Stefanie; Amélia M Silva; Fernandes, Ana; Marques, Tânia; Sandra Mariza Monteiro; Álvaro, Ana Rita. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: expression of Caspases 3, 8 and 9, AIF and p53". Trabalho apresentado em SEB’s (Society for Experimental Biology) Annual Main Meeting, Manchester, Switzerland, 2014.
Tese / Dissertação
  1. "Pharmaceutical Research on Bryophyllum pinnatum". Doutoramento, Universität Basel Philosophisch-Naturwissenschaftliche Fakultät, 2020. http://efaidnbmnnnibpcajpcglclefindmkaj/https://edoc.unibas.ch/78878/1/Dissertation_Santos.pdf.
  2. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53". Mestrado, Universidade de Trás-os-Montes e Alto Douro, 2014. https://catalogo.biblioteca.utad.pt/cgi-bin/koha/opac-detail.pl?biblionumber=69042.
  3. "Evaliation of the aderent molecules expression during pulmonar development. Mecanisms involved in the respiratory síndrome of premature babies". Licenciatura, Universidade de Trás-os-Montes e Alto Douro, 2011. https://catalogo.biblioteca.utad.pt/cgi-bin/koha/opac-detail.pl?biblionumber=64327.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/07 Bryophyllum pinnatum compounds inhibit the oxytocin-induced rise of intracellular calcium concentration in human myometrial cells Natural Products in Drug Discovery and Human Health Conference
(Lisboa, Portugal)
2019/04 A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro 18º Day of Clinical Research
(Zurique, Suiça)
2018/06 A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro 22º International Congress Phytopharm
(Horgen, Suiça)
2017/06 In vitro effect of Bryophyllum pinnatum press juice combined with atosiban on myometrium contractility SGGG (Swiss Society of Gynaecology and Obstetrics)
(Lausanne, Suiça)
2014/07 Copper induced apoptosis in Caco-2 and Hep-G2 cells: expression of Caspases 3, 8 and 9, AIF and p53 SEB’s (Society for Experimental Biology) Annual Main Meeting
(Manchester, Reino Unido)
2013 Apoptotic potential of copper: in vitro study 7th Biology Conference
Universidade Trás-os-Montes e Alto Douro (Vila Real, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2026/01/20 - Atual Online International Seminar “Bryophyllum in obstetrics: one step after another”, with the presence of Profª. Drª. Ana Paula Simões-Wüst (2026/01/20)
Seminário
 Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2025/05 - Atual Accompanying the Kindergarten nº6 – Timpeira to the UTAD facilities, visiting the Plant Physiology Laboratory, Anatomy Museum and Geology Museum
Universidade de Trás-os-Montes e Alto Douro, Portugal
2025/02/03 - Atual Theoretical seminar “Introduction to the EVOS M7000 Image Acquisition System” presented by Thermo Fisher Scientific
Seminário
2019/09 - Atual Young Researcher’ workshop (YRW) , Innsbruck, Austria
Oficina (workshop)
 67º International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA
2025/09/08 - 2025/09/10 Training in Histological Techniques, held in the histology laboratory, Department of Biology and Environment
Seminário
Universidade de Trás-os-Montes e Alto Douro, Portugal
2025 - 2025 Trainer in the "Aprender Biologia…” activity in the scope of an Open Day promoted by the University of Trás-os-Montes and Alto Douro, 7th May, Vila Real, Portugal.
2025 - 2025 Trainer in the visit to the 'Jardim de Infância nº6 - Timpeira' held under the Scientifically Probable Programme with CITAB, UTAD, 19th March, Vila Real, Portugal
2008/05/27 - 2008/06/03 “Stimulus-secretion coupling in single endocrine cells: From Biophysics to Therapeutics”, , University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Oficina (workshop)
Universidade de Trás-os-Montes e Alto Douro, Portugal

Membro de associação

Nome da associação Tipo de participação
2014 - 2014 Society for Experimental Biology (SEB) Student Membership

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2026/01/15 - Atual Journal of Gynecology and Obstetrics (2376-7820) Science Publishing Group
2020 - Atual Cell Biology Science Publishing Group

Tutoria

Tópico Nome do aluno
2025/01 - 2025/06 Pharmacological research using microorganisms Tomé Cá Júnior
2024/10 - 2025/01 Identification of Bacteria and Yeast Gertrudes Marisa Chissuquila
2019/01 - 2019/06 Effects of Bryophyllum pinnatum on in vitro cell viability Kristian Klaic
2019/01 - 2019/01 Effect of Bryophyllum pinnatum on oxytocin-induced signalling pathways in human myometrium Leonie Zurfluh
2018/01 - 2018/08 Influence of oxytocin receptor polymorphisms on the in vitro contractility of human myomentrium strips Fabienne Fueg
2013/01 - 2013/06 Apoptotic potencial of copper: in vitro study in Hep-G2 cells Ana João Rocha Fernandes
2013/01 - 2013/06 Effect of copper toxicity in apoptose induction in the human epitelial intestinal cell line Caco-2 Tânia Monteiro Marques
Distinções

Prémio

2018 Award of Best Poster in Pharmaceutical Biology at the 11º Swiss Pharma Science Day