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Stefanie Lopes dos Santos. Completed the Mestrado in Laboratorial and Clinical Biology in 2014 by Universidade de Trás-os-Montes e Alto Douro, Licenciatura in Biochemistry in 2012 by Universidade de Trás-os-Montes e Alto Douro and Doktor (PhD) in Pharmaceutical Sciences in 2020 by Universität Basel. Is Researcher in Universidade de Trás-os-Montes e Alto Douro. Published 7 articles in journals. Has received 1 awards and/or honors. Participates and/or participated as Research Fellow in 1 project(s) and Researcher in 1 project(s).
Identification

Personal identification

Full name
Stefanie Lopes dos Santos

Citation names

  • Santos, Stefanie

Author identifiers

Ciência ID
0A1F-1BA1-8CF3
ORCID iD
0000-0002-2020-6538
Google Scholar ID
https://scholar.google.com/citations?user=E2kJeSkAAAAJ&
Researcher Id
MBG-4027-2025
Scopus Author Id
57207833709

Email addresses

  • stefsantos.01@hotmail.com (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Natural sciences - Biological Sciences - Plant sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016 - 2020
Concluded
Pharmaceutical Sciences (Doktor (PhD))
Universität Basel, Switzerland
"Pharmaceutical Research on Bryophyllum pinnatum" (THESIS/DISSERTATION)
05/06
2014/07 - 2014/07
Concluded
Infectious and parasitic diseases (Outros)
Universidade de Trás-os-Montes e Alto Douro, Portugal
18/20
2011 - 2014
Concluded
Laboratorial and Clinical Biology (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Apoptotic Potencial of copper: in vitro study. Expression of caspases 3, 8 and 9, AIF and protein p53" (THESIS/DISSERTATION)
19/20
2005 - 2012
Concluded
Biochemistry (Bachelor)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Evaluation of the expression of adherent molecules during lung development. Mechanisms involved in the respiratory syndrome of premature infants" (THESIS/DISSERTATION)
19/20
Affiliation

Others

Category
Host institution
Employer
2024/09/01 - 2025/12/31 Researcher Universidade de Trás-os-Montes e Alto Douro, Portugal
Universidade de Trás-os-Montes e Alto Douro, Portugal
2024/05/15 - 2024/08/31 Research Fellow (Project BE@T com a Referência nº BI/UTAD/21/2024) Universidade de Trás-os-Montes e Alto Douro, Portugal
Universidade de Trás-os-Montes e Alto Douro, Portugal
2023/10/01 - 2023/12/15 Laboratory Technician Cosmetek, Portugal
2016/09 - 2020/08 PhD student UniversitätsSpital Zürich Klinik für Gynäkologie, Switzerland
2016/06/01 - 2016/08/31 Research Trainee UniversitätsSpital Zürich, Switzerland
Projects

Contract

Designation Funders
2024/09/01 - 2025/12/31 ANSWER - SustAiNable Safe WinERies: Identification and mapping of microorganisms and their susceptibility to UVC radiation - new approach to develop robots for winery disinfection
C644866286-00000011
Researcher
I&D Vine&Wine Portugal Driving Sustainable Growth Through Smart Innovation, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2024/07/15 - 2024/08/31 BE@T – Bioeconomy for Textiles and Clothing to Reinforce the National Bioeconomy, Textile and Clothing Sector
BI/UTAD/21/2024
Research Fellow
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. Santos, Stefanie; Zurfluh, Leonie; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula ; Simões-Wust, Ana Paula; Hamburger, Matthias. Corresponding author: Zurfluh, Leonie. "Bryophyllum pinnatum attenuates oxytocin-induced pro-inflammatory signalling pathways in human myometrial cells". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), Geneva, Switzerland, 2023.
  2. Zurfluh, Leonie; Santos, Stefanie; Haslinger, Christian; Mennet, Monica; von Mandach, Ursula; Potterat, Olivier; Simões-Wust, Ana Paula. "Bryphyllum pinnatum prevents Prostaglandin F2alpha-induced contractility of human myometrium in vitro". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), Geneva, Switzerland, 2022.
  3. Santos, Stefanie; Zurfluh, Leonie; Mennet, Monica; von Mandach, Ursula; Potterat, Olivier; Hamburger, Matthias; Simões-Wust, Ana Paula. Corresponding author: Zurfluh, Leonie. "Bryophyllum pinnatum compounds inhibit oxytocin-induced signalling pathways in human myometrial cells". Paper presented in Tetranational Congress: Phytotherapy, Zurich, Switzerland, 2022.
  4. Santos, Stefanie; Zurfluh, Leonie; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit oxytocin-induced signalling pathways in human myometrial cells". Paper presented in 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Virtual-meeting, 2021.
  5. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Innsbruck, Austria, 2019.
  6. Santos, Stefanie; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "Bryophyllum pinnatum fractions inhibit the oxytocin-induced increase of intracellular calcium concentration in human myometrial cells". Paper presented in 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Innsbruck, Austria, 2019.
  7. Santos, Stefanie; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit the oxytocin-induced rise of intracellular calcium concentration in human myometrial cells". Paper presented in 12th Swiss Pharma Science Day, Bern, Switzerland, 2019.
  8. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), Saint Gallen, Switzerland, 2019.
  9. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in 11th Swiss Pharma Science Day, Bern, Switzerland, 2018.
  10. Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in 22nd International Congress Phytopharm, Wädenswil, Switzerland, 2018.
  11. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursular; Simões-Wust, Ana Paula. "Bryophyllum pinnatum press juice enhances the tocolytic effect of nifedipine on in vitro myometrium contractility". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), Interlaken, Switzerland, 2018.
  12. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect on myometrium contractility of a combination of Bryophyllum pinnatum juice and atosiban". Paper presented in 65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, Basel, Switzerland, 2017.
  13. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect on myometrial contractility of a combination of Bryophyllum pinnatum press juice and nifedipine". Paper presented in 10th Swiss Pharma Science Day, Bern, Switzerland, 2017.
  14. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect on myometrial contractility of a combination of Bryophyllum pinnatum press juice and atosiban". Paper presented in 10th Swiss Pharma Science Day, Bern, Switzerland, 2017.
  15. Santos, Stefanie; Haslinger, Christian; Hamburger, Matthias; Mennet, Monica; Potterat, Olivier; Schnelle, Martin; von Mandach, Ursula; Simões-Wust, Ana Paula. "In vitro effect of Bryophyllum pinnatum press juice combined with atosiban on myometrium contractility". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), Lausanne, Switzerland, 2017.
  16. Santos, Stefanie; Amélia M Silva; Fernandes, Ana; Marques, Tânia; Sandra Mariza Monteiro; Álvaro, Ana Rita. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: expression of Caspases 3, 8 and 9, AIF and p53". Paper presented in SEB’s (Society for Experimental Biology) Annual Main Meeting, Manchester, Switzerland, 2014.
Journal article
  1. Zurfluh, Leonie; Santos, Stefanie; Ruppen, Annina; Mosbacher, Johannes; Haslinger, Christian; Ochsenbein-Kölble, Nicole; Potterat, Olivier; Simões-Wüst, Ana Paula. "Bryophyllum pinnatum modulation of signaling pathways relevant for preterm labor in human myometrial cells". Biomedicine & Pharmacotherapy 184 (2025): 117919. https://doi.org/10.1016/j.biopha.2025.117919.
    Published • 10.1016/j.biopha.2025.117919
  2. Santos, Stefanie; Zurfluh, L.; Mennet, M.; Potterat, O.; von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Corrigendum: Bryophyllum pinnatum compounds inhibit oxytocin-induced signaling pathways in human myometrial cells". Frontiers in Pharmacology 14 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85148603150&partnerID=MN8TOARS.
    10.3389/fphar.2023.1141346
  3. Santos, S.; Zurfluh, L.; Mennet, M.; Potterat, O.; von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Bryophyllum pinnatum Compounds Inhibit Oxytocin-Induced Signaling Pathways in Human Myometrial Cells". Frontiers in Pharmacology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102148393&partnerID=MN8TOARS.
    10.3389/fphar.2021.632986
  4. Santos, S.; Haslinger, C.; Klaic, K.; Faleschini, M.T.; Mennet, M.; Potterat, O.; Von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility in Vitro". Planta Medica 85 5 (2019): 385-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062947790&partnerID=MN8TOARS.
    10.1055/a-0810-7704
  5. Santos, S.; Haslinger, C.; Mennet, M.; Von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: An in vitro study". BMC Complementary and Alternative Medicine 19 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074545700&partnerID=MN8TOARS.
    10.1186/s12906-019-2711-5
  6. Füeg, F.; Santos, S.; Haslinger, C.; Stoiber, B.; Schäffer, L.; Grünblatt, E.; Zimmermann, R.; Simões-Wüst, A.P.. "Influence of oxytocin receptor single nucleotide sequence variants on contractility of human myometrium: An in vitro functional study". BMC Medical Genetics 20 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075044407&partnerID=MN8TOARS.
    10.1186/s12881-019-0894-8
  7. Santos, S.; Silva, A.M.; Matos, M.; Monteiro, S.M.; Álvaro, A.R.. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53". Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 185-186 (2016): 138-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963665511&partnerID=MN8TOARS.
    10.1016/j.cbpc.2016.03.010
  8. Santos, S; Carvalho, R; Pinto, M; Coelho, A C; Gonçalves, C; Bairos, V. "Expression of E-Cadherin and Beta-Catenin in the Developing Lung after Prenatal Administration of Vitamin A". Pediatric Research 70 (2011): 544-544. https://doi.org/10.1038/pr.2011.769.
    10.1038/pr.2011.769
Thesis / Dissertation
  1. "Pharmaceutical Research on Bryophyllum pinnatum". PhD, Universität Basel Philosophisch-Naturwissenschaftliche Fakultät, 2020. http://efaidnbmnnnibpcajpcglclefindmkaj/https://edoc.unibas.ch/78878/1/Dissertation_Santos.pdf.
  2. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53". Master, Universidade de Trás-os-Montes e Alto Douro, 2014. https://catalogo.biblioteca.utad.pt/cgi-bin/koha/opac-detail.pl?biblionumber=69042.
  3. "Evaliation of the aderent molecules expression during pulmonar development. Mecanisms involved in the respiratory síndrome of premature babies". Degree, Universidade de Trás-os-Montes e Alto Douro, 2011. https://catalogo.biblioteca.utad.pt/cgi-bin/koha/opac-detail.pl?biblionumber=64327.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07 Bryophyllum pinnatum compounds inhibit the oxytocin-induced rise of intracellular calcium concentration in human myometrial cells Natural Products in Drug Discovery and Human Health Conference
(Lisboa, Portugal)
2019/04 A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro 18º Day of Clinical Research
(Zurique, Switzerland)
2018/06 A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro 22º International Congress Phytopharm
(Horgen, Switzerland)
2017/06 In vitro effect of Bryophyllum pinnatum press juice combined with atosiban on myometrium contractility SGGG (Swiss Society of Gynaecology and Obstetrics)
(Lausanne, Switzerland)
2014/07 Copper induced apoptosis in Caco-2 and Hep-G2 cells: expression of Caspases 3, 8 and 9, AIF and p53 SEB’s (Society for Experimental Biology) Annual Main Meeting
(Manchester, United Kingdom)
2013 Apoptotic potential of copper: in vitro study 7th Biology Conference
Universidade Trás-os-Montes e Alto Douro (Vila Real, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2026/01/20 - Current Online International Seminar “Bryophyllum in obstetrics: one step after another”, with the presence of Profª. Drª. Ana Paula Simões-Wüst (2026/01/20)
Seminar
Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2025/05 - Current Accompanying the Kindergarten nº6 – Timpeira to the UTAD facilities, visiting the Plant Physiology Laboratory, Anatomy Museum and Geology Museum
Universidade de Trás-os-Montes e Alto Douro, Portugal
2025/02/03 - Current Theoretical seminar “Introduction to the EVOS M7000 Image Acquisition System” presented by Thermo Fisher Scientific
Seminar
2019/09 - Current Young Researcher’ workshop (YRW) , Innsbruck, Austria
Workshop
67º International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA
2025/09/08 - 2025/09/10 Training in Histological Techniques, held in the histology laboratory, Department of Biology and Environment
Seminar
Universidade de Trás-os-Montes e Alto Douro, Portugal
2025 - 2025 Trainer in the "Aprender Biologia…” activity in the scope of an Open Day promoted by the University of Trás-os-Montes and Alto Douro, 7th May, Vila Real, Portugal.
2025 - 2025 Trainer in the visit to the 'Jardim de Infância nº6 - Timpeira' held under the Scientifically Probable Programme with CITAB, UTAD, 19th March, Vila Real, Portugal
2008/05/27 - 2008/06/03 “Stimulus-secretion coupling in single endocrine cells: From Biophysics to Therapeutics”, , University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Workshop
Universidade de Trás-os-Montes e Alto Douro, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2026/01/15 - Current Journal of Gynecology and Obstetrics (2376-7820) Science Publishing Group
2020 - Current Cell Biology Science Publishing Group

Association member

Society Organization name Role
2014 - 2014 Society for Experimental Biology (SEB) Student Membership

Mentoring / Tutoring

Topic Student name
2025/01 - 2025/06 Pharmacological research using microorganisms Tomé Cá Júnior
2024/10 - 2025/01 Identification of Bacteria and Yeast Gertrudes Marisa Chissuquila
2019/01 - 2019/06 Effects of Bryophyllum pinnatum on in vitro cell viability Kristian Klaic
2019/01 - 2019/01 Effect of Bryophyllum pinnatum on oxytocin-induced signalling pathways in human myometrium Leonie Zurfluh
2018/01 - 2018/08 Influence of oxytocin receptor polymorphisms on the in vitro contractility of human myomentrium strips Fabienne Fueg
2013/01 - 2013/06 Apoptotic potencial of copper: in vitro study in Hep-G2 cells Ana João Rocha Fernandes
2013/01 - 2013/06 Effect of copper toxicity in apoptose induction in the human epitelial intestinal cell line Caco-2 Tânia Monteiro Marques
Distinctions

Award

2018 Award of Best Poster in Pharmaceutical Biology at the 11º Swiss Pharma Science Day