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Experienced clinical microbiologist/molecular biologist scientist with special interests in the area of infectious diseases/antimicrobial development and resistance. My works in Infectious Diseases have extended for more than 24 years covering both aspects clinical, basic the translational aspects of related diseases. I have been conducting clinical and basic research on antimicrobials and multidrug-resistant (MDR) Gram-negative and Gram-positive bacterial pathogens to which treatment options are limited. Specifically, in the last nineteen years, my research goals have been to characterize evolutionary and molecular mechanisms underlying antibiotic resistance during the dynamic process of host/pathogen infections. Multi-drug resistant (MDR) organisms are important human pathogens responsible for infections to which antimicrobial options are limited. I have been fortunate enough to contribute in many areas of the field, with the personal conviction that the strategy in combating antimicrobial resistance needs to be directed from the view of multiple and coordinate efforts, basic and clinical research, collaborative studies with the pharmaceutical industry to speed up the discovery of new antibiotics, policies and measures to control the spread of resistance (hospital and community settings) and by increasing scientific collaborations with diverse parts including USA, South America and Europe. My research interests during the last years have been extended to the impact of antibiotics in the gut microbiota leading to dybiosis leading to selection of antimicrobial resistant pathogens. My activities include as a group leader, pre-clinical and correlative clinical studies, writing protocols, presenting at scientific meetings and conferences developing collaborative relationships. I have a great deal of expertise in microbiology testing, molecular biology, diagnostics, genomic, transcriptomic analysis and in-vivo models. Moreover, working in close collaboration as advisor consultant of pharmaceutical companies/drug discovery, NIH-NIAID, and WHO division antimicrobial resistance. I have invested timeless efforts in contributing and advising the field of Antimicrobial resistance by participating in revision of scientific advances and discoveries at the NIH and European Agencies, having had the opportunity of contributing my input to important decisions of funding and studies in the area of Antimicrobial Resistance. In addition, I have been contributing to the identification of antibacterial approaches and their execution, trained in areas of GCP, clinical trials, and CRO relationships. More important, over the years I have strongly committed to mentoring young investigators and I have served and I`m serving as a primary mentor for several individuals. This extended experience has also helped me to grow as a scientist, mentor, and team leader, and making me better suited for the tasks as the evolution in the field requires.
Identification

Personal identification

Full name
Adriana Rosato

Citation names

  • Rosato, Adriana

Author identifiers

Ciência ID
B61A-36C3-2A39
Scopus Author Id
55947430200

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
1993/09/01 - 1997/04/04
Concluded
MIcrobiology and antimicrobials (Doctor of Philosophy)
Université Paris-Saclay Faculté de Pharmacie, France
1992/09/01 - 1993/07/01
Concluded
Microbiology (Master)
Université Paris-Saclay Faculté de Pharmacie, France
1982/02/01 - 1988/03/31
Concluded
Biochemistry (Bachelor)
Universidad Nacional de San Luis, Argentina
Affiliation

Science

Category
Host institution
Employer
2010/08/01 - 2020/05/01 Principal Investigator (Research) Houston Methodist Academic Institute, United States
Houston Methodist Academic Institute, United States
2004/08 - 2010/08 Principal Investigator (Research) Virginia Commonwealth University, United States
Virginia Commonwealth University, United States
1998/09/01 - 2002/10/01 Postdoc (Research) Virginia Commonwealth University, United States
1997/04/02 - 1999/05/08 Postdoc (Research) University of Southern California, United States

Teaching in Higher Education

Category
Host institution
Employer
2020/05/01 - Current Full Professor (University Teacher) University of California Riverside, United States
2010/08 - 2020/05 Associate Professor (University Teacher) Weill Cornell Medicine, United States
2002/10/01 - 2006/01/01 Assistant Professor (University Teacher) Virginia Commonwealth University, United States

Others

Category
Host institution
Employer
2020/04/08 - Current Executive Director Molecular Microbiology and Research Riverside University Health System, United States
Riverside University Health System, United States
2001/01/28 - 2006/01/01 Clinical microbiologist Virginia Commonwealth University Medical Center, United States
Projects

Grant

Designation Funders
2017 - Current Newly Identified mechanisms of Ceftaroline Resistance in Cystic Fibrosis MRSA
R56 AI1187566-NIAID
Principal investigator
National Institutes of Health
Concluded
2015 - 2016 Identification of Mode of Action and Activity against MRSA skin infections of a natural pecan extract product
N/A
Principal investigator
Gillson Longenbaugh Foundation
Concluded
2014 - 2015 Molecular Bases of DAP-mediated sensitization to ß-lactams in MRSA
R56AI102503-01A1NIH-NIAID
Principal investigator
National Institutes of Health
Concluded
2014 - 2015 Efficacy of Daptomycin/¿-lactams against VISA and homogenous DAPR/MRSA clinical strains
N/A
Principal investigator
Merck & Co Inc
Concluded
2010 - 2015 SOS mediated Beta-lactam response and Development of Homogeneous Expression of Resistance in Methicillin Resistant S. aureus clinical isolates
AIA080688-01A2
Principal investigator
National Institutes of Health
2012 - 2013 Signal Pathways responsible of “see –saw” effect between Daptomycin and ¿-lactams in MRSA strains
N/A
Principal investigator
Merck & Co Inc
2007 - 2009 A Study of Passage-Related Pathways Daptomycin and Vancomycin Resistance in S.aureus
N/A
Principal investigator
Merck & Co Inc
Concluded
2004 - 2006 Regulation of mecA expression in S.aureus Clinical Isolates
K22AI057724-01A1
Principal investigator
National Institutes of Health, United States
Concluded

Other

Designation Funders
2010 - 2013 Start-up funding
N01 AI-15447
Principal investigator
2004 - 2006 Start Package
N/A
Principal investigator
Outputs

Publications

Conference paper
  1. Costa, SS; Rosato, Adriana E.; Viveiros, Miguel; Couto, Isabel. "Development of multidrug resistance in staphylococci driven by efflux". 2018.
Journal article
  1. Rosato, Adriana E.; Msiha, Engy; Weng, Bruce; Mesisca, Michael; Gnass, Ronaldo; Gnass, Silvia; Bol, Cedric; Tabuenca, Arnold; Rosato, Roberto R.. "Rapid detection of the widely circulating B.1.617.2 (Delta) SARS-CoV-2 variant". Pathology (2022): http://dx.doi.org/10.1016/j.pathol.2022.01.001.
    Open access • Published • 10.1016/j.pathol.2022.01.001
  2. Gagetti, Paula; Rosato, Roberto R.; Rosato, Adriana E.. "Staphylococcus pseudintermedius’s PBP4 Is Directly Associated with the Dissociated Oxacillin and Cefoxitin Phenotype". Antibiotics 10 11 (2021): 1299. http://dx.doi.org/10.3390/antibiotics10111299.
    Open access • Published • 10.3390/antibiotics10111299
  3. López, Gerson-Dirceu; Suesca, Elizabeth; Álvarez-Rivera, Gerardo; Rosato, Adriana E.; Ibáñez, Elena; Cifuentes, Alejandro; Leidy, Chad; Carazzone, Chiara. "Carotenogenesis of Staphylococcus aureus: New insights and impact on membrane biophysical properties". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866 8 (2021): 158941. http://dx.doi.org/10.1016/j.bbalip.2021.158941.
    Published • 10.1016/j.bbalip.2021.158941
  4. Ersoy, Selvi C.; Chambers, Henry F.; Proctor, Richard A.; Rosato, Adriana E.; Mishra, Nagendra N.; Xiong, Yan Q.; Bayer, Arnold S.. "Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus". Antimicrobial Agents and Chemotherapy 65 5 (2021): http://dx.doi.org/10.1128/aac.02621-20.
    Published • 10.1128/aac.02621-20
  5. Varela, Maria Celeste; Roch, Melanie; Taglialegna, Agustina; Long, Scott W.; Saavedra, Matthew Ojeda; Rose, Warren E.; Davis, James J.; et al. "Carbapenems drive the collateral resistance to ceftaroline in cystic fibrosis patients with MRSA". Communications Biology 3 1 (2020): http://dx.doi.org/10.1038/s42003-020-01313-5.
    Published • 10.1038/s42003-020-01313-5
  6. Greber, Katarzyna E.; Roch, Melanie; Rosato, Mauro A.; Martinez, Maria P.; Rosato, Adriana E.. "Efficacy of newly generated short antimicrobial cationic lipopeptides against methicillin-resistant Staphylococcus aureus (MRSA)". International Journal of Antimicrobial Agents 55 3 (2020): 105827. http://dx.doi.org/10.1016/j.ijantimicag.2019.10.008.
    10.1016/j.ijantimicag.2019.10.008
  7. Roch, Melanie; Varela, Maria Celeste; Taglialegna, Agustina; Rosato, Adriana E. "Tedizolid is a promising antimicrobial option for the treatment of Staphylococcus aureus infections in cystic fibrosis patients". Journal of Antimicrobial Chemotherapy 75 1 (2019): 126-134. http://dx.doi.org/10.1093/jac/dkz418.
    10.1093/jac/dkz418
  8. Gagetti, Paula; Wattam, Alice R.; Giacoboni, Gabriela; De Paulis, Adriana; Bertona, Eugenia; Corso, Alejandra; Rosato, Adriana E.. "Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina". BMC Veterinary Research 15 1 (2019): http://dx.doi.org/10.1186/s12917-019-1990-x.
    Open access • 10.1186/s12917-019-1990-x
  9. Gagetti, Paula; Wattam, Alice R.; Giacoboni, Gabriela; De Paulis, Adriana; Bertona, Eugenia; Corso, Alejandra; Rosato, Adriana E.. "Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina". BMC Veterinary Research 15 1 (2019): http://dx.doi.org/10.1186/s12917-019-1990-x.
    Published • 10.1186/s12917-019-1990-x
  10. Taglialegna, Agustina; Varela, Maria C.; Rosato, Roberto R.; Rosato, Adriana E.. "VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant Staphylococcus aureus Infection". mSphere 4 1 (2019): http://dx.doi.org/10.1128/msphere.00557-18.
    Published • 10.1128/msphere.00557-18
  11. De Belder, Denise; Lucero, Celeste; Rapoport, Melina; Rosato, Adriana; Faccone, Diego; Petroni, Alejandro; Pasteran, Fernando; et al. "Genetic Diversity of KPC-ProducingEscherichia coli, Klebsiella oxytoca, Serratia marcescens, andCitrobacter freundiiIsolates from Argentina". Microbial Drug Resistance 24 7 (2018): 958-965. http://dx.doi.org/10.1089/mdr.2017.0213.
    Published • 10.1089/mdr.2017.0213
  12. Roch, Melanie; Varela, Maria Celeste; Taglialegna, Agustina; Rose, Warren E.; Rosato, Adriana E.. "Activity of Telavancin against Staphylococcus aureus Isolates, Including Those with Decreased Susceptibility to Ceftaroline, from Cystic Fibrosis Patients". Antimicrobial Agents and Chemotherapy 62 9 (2018): http://dx.doi.org/10.1128/aac.00956-18.
    Published • 10.1128/aac.00956-18
  13. Zheng, Xuting; Berti, Andrew D.; McCrone, Sue; Roch, Melanie; Rosato, Adriana E.; Rose, Warren E.; Chen, Baiyi. "Combination Antibiotic Exposure Selectively Alters the Development of Vancomycin Intermediate Resistance in Staphylococcus aureus". Antimicrobial Agents and Chemotherapy 62 2 (2018): http://dx.doi.org/10.1128/aac.02100-17.
    Published • 10.1128/aac.02100-17
  14. Roch, Melanie; Gagetti, Paula; Davis, James; Ceriana, Paola; Errecalde, Laura; Corso, Alejandra; Rosato, Adriana E.. "Daptomycin Resistance in Clinical MRSA Strains Is Associated with a High Biological Fitness Cost". Frontiers in Microbiology 8 (2017): http://dx.doi.org/10.3389/fmicb.2017.02303.
    Published • 10.3389/fmicb.2017.02303
  15. Renzoni, Adriana; Kelley, William L.; Rosato, Roberto R.; Martinez, Maria P.; Roch, Melanie; Fatouraei, Maryam; Haeusser, Daniel P.; et al. "Molecular Bases Determining Daptomycin Resistance-Mediated Resensitization to ß-Lactams (Seesaw Effect) in Methicillin-Resistant Staphylococcus aureus". Antimicrobial Agents and Chemotherapy 61 1 (2017): http://dx.doi.org/10.1128/aac.01634-16.
    10.1128/aac.01634-16
  16. Gagetti, P.; Pasteran, F.; Martinez, M. P.; Fatouraei, M.; Gu, J.; Fernandez, R.; Paz, L.; et al. "Modeling Meropenem Treatment, Alone and in Combination with Daptomycin, for KPC-Producing Klebsiella pneumoniae Strains with Unusually Low Carbapenem MICs". Antimicrobial Agents and Chemotherapy 60 8 (2016): 5047-5050. http://dx.doi.org/10.1128/aac.00168-16.
    10.1128/aac.00168-16
  17. Jousselin, Ambre; Manzano, Caroline; Biette, Alexandra; Reed, Patricia; Pinho, Mariana G.; Rosato, Adriana E.; Kelley, William L.; Renzoni, Adriana. "The Staphylococcus aureus Chaperone PrsA Is a New Auxiliary Factor of Oxacillin Resistance Affecting Penicillin-Binding Protein 2A". Antimicrobial Agents and Chemotherapy 60 3 (2016): 1656-1666. http://dx.doi.org/10.1128/aac.02333-15.
    10.1128/aac.02333-15
  18. Costa, Sofia Santos; Viveiros, Miguel; Rosato, Adriana E.; Melo-Cristino, José; Couto, Isabel. "Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus". (2015): http://www.scopus.com/inward/record.url?scp=84945118570&partnerID=8YFLogxK.
    https://doi.org/10.1186/s12866-015-0572-8
  19. Anaya-Bergman, C.; Rosato, A.; Lewis, J.P.. "Iron- and hemin-dependent gene expression ofPorphyromonas gingivalis". Molecular Oral Microbiology 30 1 (2014): 39-61. http://dx.doi.org/10.1111/omi.12066.
    10.1111/omi.12066
  20. Long, S. Wesley; Olsen, Randall J.; Mehta, Shrenik C.; Palzkill, Timothy; Cernoch, Patricia L.; Perez, Katherine K.; Musick, William L.; Rosato, Adriana E.; Musser, James M.. "PBP2a Mutations Causing High-Level Ceftaroline Resistance in Clinical Methicillin-Resistant Staphylococcus aureus Isolates". Antimicrobial Agents and Chemotherapy 58 11 (2014): 6668-6674. http://dx.doi.org/10.1128/aac.03622-14.
    10.1128/aac.03622-14
  21. Fernandez, Regina; Paz, Liliana I.; Rosato, Roberto R.; Rosato, Adriana E.. "Ceftaroline Is Active against Heteroresistant Methicillin-Resistant Staphylococcus aureus Clinical Strains despite Associated Mutational Mechanisms and Intermediate Levels of Resistance". Antimicrobial Agents and Chemotherapy 58 10 (2014): 5736-5746. http://dx.doi.org/10.1128/aac.03019-14.
    10.1128/aac.03019-14
  22. Rosato, Roberto R.; Fernandez, Regina; Paz, Liliana I.; Singh, Christopher R.; Rosato, Adriana E.. "TCA Cycle-Mediated Generation of ROS Is a Key Mediator for HeR-MRSA Survival under ß-Lactam Antibiotic Exposure". PLoS ONE 9 6 (2014): e99605. http://dx.doi.org/10.1371/journal.pone.0099605.
    10.1371/journal.pone.0099605
  23. Palacios, Lucia; Rosado, Helena; Micol, Vicente; Rosato, Adriana E.; Bernal, Patricia; Arroyo, Raquel; Grounds, Helen; et al. "Staphylococcal Phenotypes Induced by Naturally Occurring and Synthetic Membrane-Interactive Polyphenolic ß-Lactam Resistance Modifiers". PLoS ONE 9 4 (2014): e93830. http://dx.doi.org/10.1371/journal.pone.0093830.
    Open access • 10.1371/journal.pone.0093830
  24. Dean, Melissa A.; Olsen, Randall J.; Long, S. Wesley; Rosato, Adriana E.; Musser, James M.. "Identification of Point Mutations in Clinical Staphylococcus aureus Strains That Produce Small-Colony Variants Auxotrophic for Menadione". Infection and Immunity 82 4 (2014): 1600-1605. http://dx.doi.org/10.1128/iai.01487-13.
    10.1128/iai.01487-13
  25. Keaton, Mignon A.; Rosato, Roberto R.; Plata, Konrad B.; Singh, Christopher R.; Rosato, Adriana E.. "Exposure of Clinical MRSA Heterogeneous Strains to ß-Lactams Redirects Metabolism to Optimize Energy Production through the TCA Cycle". PLoS ONE 8 8 (2013): e71025. http://dx.doi.org/10.1371/journal.pone.0071025.
    10.1371/journal.pone.0071025
  26. Plata, Konrad B.; Riosa, Sarah; Singh, Christopher R.; Rosato, Roberto R.; Rosato, Adriana E.. "Targeting of PBP1 by ß-lactams Determines recA/SOS Response Activation in Heterogeneous MRSA Clinical Strains". PLoS ONE 8 4 (2013): e61083. http://dx.doi.org/10.1371/journal.pone.0061083.
    10.1371/journal.pone.0061083
  27. Mehta, Shrenik; Singh, Christopher; Plata, Konrad B.; Chanda, Palas K.; Paul, Arundhati; Riosa, Sarah; Rosato, Roberto R.; Rosato, Adriana E.. "ß-Lactams Increase the Antibacterial Activity of Daptomycin against Clinical Methicillin-Resistant Staphylococcus aureus Strains and Prevent Selection of Daptomycin-Resistant Derivatives". Antimicrobial Agents and Chemotherapy 56 12 (2012): 6192-6200. http://dx.doi.org/10.1128/aac.01525-12.
    10.1128/aac.01525-12
  28. Bearman, Gonzalo M. L.; Rosato, Adriana; Elam, Kara; Sanogo, Kakotan; Stevens, Michael P.; Sessler, Curtis N.; Wenzel, Richard P.. "A Crossover Trial of Antimicrobial Scrubs to Reduce Methicillin-Resistant Staphylococcus aureus Burden on Healthcare Worker Apparel". Infection Control & Hospital Epidemiology 33 3 (2012): 268-275. http://dx.doi.org/10.1086/664045.
    Published • 10.1086/664045
  29. Ciustea, Mihai; Mootien, Sara; Rosato, Adriana E.; Perez, Oriana; Cirillo, Pier; Yeung, Kacheong R.; Ledizet, Michel; et al. "Thiadiazolidinones: A new class of alanine racemase inhibitors with antimicrobial activity against methicillin-resistant Staphylococcus aureus". Biochemical Pharmacology 83 3 (2012): 368-377. http://dx.doi.org/10.1016/j.bcp.2011.11.021.
    10.1016/j.bcp.2011.11.021
  30. Mehta, Shrenik; Cuirolo, Arabela X.; Plata, Konrad B.; Riosa, Sarah; Silverman, Jared A.; Rubio, Aileen; Rosato, Roberto R.; Rosato, Adriana E.. "VraSR Two-Component Regulatory System Contributes tomprF-Mediated Decreased Susceptibility to Daptomycin inIn Vivo-Selected Clinical Strains of Methicillin-Resistant Staphylococcus aureus". Antimicrobial Agents and Chemotherapy 56 1 (2011): 92-102. http://dx.doi.org/10.1128/aac.00432-10.
    10.1128/aac.00432-10
  31. Plata, Konrad B.; Rosato, Roberto R.; Rosato, Adriana E.. "Fate of Mutation Rate Depends on agr Locus Expression during Oxacillin-Mediated Heterogeneous-Homogeneous Selection in Methicillin-Resistant Staphylococcus aureus Clinical Strains". Antimicrobial Agents and Chemotherapy 55 7 (2011): 3176-3186. http://dx.doi.org/10.1128/aac.01119-09.
    10.1128/aac.01119-09
  32. Cuirolo, Arabela; Canigia, Liliana Fernández; Gardella, Noella; Fernández, Silvina; Gutkind, Gabriel; Rosato, Adriana; Mollerach, Marta. "Oxacillin- and cefoxitin-susceptible meticillin-resistant Staphylococcus aureus (MRSA)". International Journal of Antimicrobial Agents 37 2 (2011): 178-179. http://dx.doi.org/10.1016/j.ijantimicag.2010.10.017.
    10.1016/j.ijantimicag.2010.10.017
  33. Bearman, Gonzalo M.L.; Rosato, Adriana E.; Assanasen, Susan; Kleiner, Elizabeth A.; Elam, Kara; Haner, Cheryl; Wenzel, Richard P.. "Nasal carriage of inducible dormant and community-associated methicillin-resistant Staphylococcus aureus in an ambulatory population of predominantly university students". International Journal of Infectious Diseases 14 (2010): e18-e24. http://dx.doi.org/10.1016/j.ijid.2009.09.005.
    10.1016/j.ijid.2009.09.005
  34. Bearman, Gonzalo; Rosato, Adriana E.; Duane, Therese M.; Elam, Kara; Sanogo, Kakotan; Haner, Cheryl; Kazlova, Valentina; Edmond, Michael B.. "Trial of Universal Gloving with Emollient-Impregnated Gloves to Promote Skin Health and Prevent the Transmission of Multidrug-Resistant Organisms in a Surgical Intensive Care Unit". Infection Control & Hospital Epidemiology 31 05 (2010): 491-497. http://dx.doi.org/10.1086/651671.
    10.1086/651671
  35. Higgins, Paul G.; Rosato, Adriana E.; Seifert, Harald; Archer, Gordon L.; Wisplinghoff, Hilmar. "Differential Expression of ccrA in Methicillin-Resistant Staphylococcus aureus Strains Carrying Staphylococcal Cassette Chromosome mec Type II and IVa Elements". Antimicrobial Agents and Chemotherapy 53 10 (2009): 4556-4558. http://dx.doi.org/10.1128/aac.00395-09.
    10.1128/aac.00395-09
  36. Cuirolo, Arabela; Plata, Konrad; Rosato, Adriana E.. "Development of homogeneous expression of resistance in methicillin-resistant Staphylococcus aureus clinical strains is functionally associated with a ß-lactam-mediated SOS response". Journal of Antimicrobial Chemotherapy 64 1 (2009): 37-45. http://dx.doi.org/10.1093/jac/dkp164.
    10.1093/jac/dkp164
  37. Gardella, Noella; von Specht, Martha; Cuirolo, Arabela; Rosato, Adriana; Gutkind, Gabriel; Mollerach, Marta. "Community-associated methicillin-resistant Staphylococcus aureus, eastern Argentina". Diagnostic Microbiology and Infectious Disease 62 3 (2008): 343-347. http://dx.doi.org/10.1016/j.diagmicrobio.2008.07.008.
    10.1016/j.diagmicrobio.2008.07.008
  38. Stevens, Michael P.; Bearman, Gonzalo; Rosato, Adriana; Edmond, Michael. "Community-Acquired Methicillin Resistant Staphylococcus aureus in a Women’s Collegiate Basketball Team". Southern Medical Journal 101 10 (2008): 1067-1068. http://dx.doi.org/10.1097/smj.0b013e318186b81c.
    10.1097/smj.0b013e318186b81c
  39. Forbes, Betty A.; Bombicino, Karina; Plata, Konrad; Cuirolo, Arabela; Webber, Dawn; Bender, Connie L.; Rosato, Adriana E.. "Unusual form of oxacillin resistance in methicillin-resistant Staphylococcus aureus clinical strains". Diagnostic Microbiology and Infectious Disease 61 4 (2008): 387-395. http://dx.doi.org/10.1016/j.diagmicrobio.2008.04.003.
    10.1016/j.diagmicrobio.2008.04.003
  40. Goldstein, Fred; Perutka, Jiri; Cuirolo, Arabela; Plata, Konrad; Faccone, Diego; Morris, Joanne; Sournia, Aude; et al. "Identification and Phenotypic Characterization of a ß-Lactam-Dependent, Methicillin-Resistant Staphylococcus aureus Strain". Antimicrobial Agents and Chemotherapy 51 7 (2007): 2514-2522. http://dx.doi.org/10.1128/aac.00040-07.
    10.1128/aac.00040-07
  41. Bearman, Gonzalo M. L.; Marra, Alexandre R. [UNIFESP]; Sessler, Curtis N.; Smith, Wally R.; Rosato, Adriana; Laplante, Justin K.; Wenzel, Richard P.; Edmond, Michael B.. "A controlled trial of universal gloving versus contact precautions for preventing the transmission of multidrug-resistant organisms". (2007): http://repositorio.unifesp.br/handle/11600/30155.
    http://dx.doi.org/10.1016/j.ajic.2007.02.011
  42. Lewis, Janina P.; Plata, Konrad; Yu, Fan; Rosato, Adriana; Anaya, Cecilia. "Transcriptional organization, regulation and role of the Porphyromonas gingivalis W83 hmu haemin-uptake locus". Microbiology 152 11 (2006): 3367-3382. http://dx.doi.org/10.1099/mic.0.29011-0.
    10.1099/mic.0.29011-0
  43. Faccone, Diego; Andres, Patricia; Galas, Marcelo; Tokumoto, Marta; Rosato, Adriana; Corso, Alejandra. "Emergence of a Streptococcus pneumoniae Clinical Isolate Highly Resistant to Telithromycin and Fluoroquinolones". Journal of Clinical Microbiology 43 11 (2005): 5800-5803. http://dx.doi.org/10.1128/jcm.43.11.5800-5803.2005.
    10.1128/jcm.43.11.5800-5803.2005
  44. Rosato, Adriana E.; Tallent, Sandra M.; Edmond, Michael B.; Bearman, Gonzalo M.L.. "Susceptibility of coagulase-negative staphylococcal nosocomial bloodstream isolates to the chlorhexidine/silver sulfadiazine-impregnated central venous catheter". American Journal of Infection Control 32 8 (2004): 486-488. http://dx.doi.org/10.1016/j.ajic.2004.06.002.
    10.1016/j.ajic.2004.06.002
  45. Wisplinghoff, Hilmar; Rosato, Adriana E.; Enright, Mark C.; Noto, Michael; Craig, William; Archer, Gordon L.. "Related Clones Containing SCC mec Type IV Predominate among Clinically Significant Staphylococcus epidermidis Isolates". Antimicrobial Agents and Chemotherapy 47 11 (2003): 3574-3579. http://dx.doi.org/10.1128/aac.47.11.3574-3579.2003.
    10.1128/aac.47.11.3574-3579.2003
  46. Mongodin, Emmanuel; Finan, Jon; Climo, Michael W.; Rosato, Adriana; Gill, Steven; Archer, Gordon L.. "Microarray Transcription Analysis of Clinical Staphylococcus aureus Isolates Resistant to Vancomycin". Journal of Bacteriology 185 15 (2003): 4638-4643. http://dx.doi.org/10.1128/jb.185.15.4638-4643.2003.
    10.1128/jb.185.15.4638-4643.2003
  47. Rosato, Adriana E.; Craig, William A.; Archer, Gordon L.. "Quantitation of mecA Transcription in Oxacillin-Resistant Staphylococcus aureus Clinical Isolates". Journal of Bacteriology 185 11 (2003): 3446-3452. http://dx.doi.org/10.1128/jb.185.11.3446-3452.2003.
    10.1128/jb.185.11.3446-3452.2003
  48. Rosato, Adriana E.; Kreiswirth, Barry N.; Craig, William A.; Eisner, William; Climo, Michael W.; Archer, Gordon L.. "mecA - blaZ Corepressors in Clinical Staphylococcus aureus Isolates". Antimicrobial Agents and Chemotherapy 47 4 (2003): 1460-1463. http://dx.doi.org/10.1128/aac.47.4.1460-1463.2003.
    10.1128/aac.47.4.1460-1463.2003
  49. Finan, J. E.; Rosato, A. E.; Dickinson, T. M.; Ko, D.; Archer, Gordon L.. "Conversion of Oxacillin-Resistant Staphylococci from Heterotypic to Homotypic Resistance Expression". Antimicrobial Agents and Chemotherapy 46 1 (2002): 24-30. http://dx.doi.org/10.1128/aac.46.1.24-30.2002.
    10.1128/aac.46.1.24-30.2002
  50. Rosato, Adriana E.; Lee, Bonnie S.; Nash, Kevin A.. "Inducible Macrolide Resistance in Corynebacterium jeikeium". Antimicrobial Agents and Chemotherapy 45 7 (2001): 1982-1989. http://dx.doi.org/10.1128/aac.45.7.1982-1989.2001.
    10.1128/aac.45.7.1982-1989.2001
  51. "Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin". Journal of Antimicrobial Chemotherapy 43 4 (1999): 559-562. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032931288&partnerID=MN8TOARS.
    Published
  52. "A new ketolide, HMR 3004, active against streptococci inducibly resistant to erythromycin". Antimicrobial Agents and Chemotherapy 42 6 (1998): 1392-1396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031805501&partnerID=MN8TOARS.
    Published
  53. "Analysis of regulatory region of ermAM genes in streptococci and enterococci highly resistant to macrolides and lincosamides". Advances in Experimental Medicine and Biology 418 (1997): 495-498. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030881487&partnerID=MN8TOARS.
    Published
  54. "Inducible and constitutive expression of resistance to glycopeptides and vancomycin dependence in glycopeptide-resistant Enterococcus avium". Antimicrobial Agents and Chemotherapy 39 4 (1995): 830-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028932504&partnerID=MN8TOARS.
    Published
  55. Goldstein, F. W.; Péan, Y.; Rosato, A.; Gertner, J.; Gutmann, L.. "Characterization of ceftriaxone-resistant Enterobacteriaceae: a multicentre study in 26 French hospitals". Journal of Antimicrobial Chemotherapy 32 4 (1993): 595-603. http://dx.doi.org/10.1093/jac/32.4.595.
    Published • 10.1093/jac/32.4.595
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2016/09 Rosato AE. Cross-talks between mutated-MprF and PrsA proteins contribute to ß-lactam sensitization (see-saw effect) and synergy during daptomycin resistance in MRSA" 3rd International Conference Pathophysiology of Staphylococci
2016/06 Rosato AE. Genetic Determinants and Role of Carbapenems in Acquisition of Ceftaroline Resistance in Cystic fibrosis- MRSA strains ASM/ICAAC
2015/07 Rosato AE. Daptomycin resistance re-sensitize MRSA to ß-lactams by modulating cell membrane and cell wall interactions. Gordon Conference in Staphylococcal Diseases
2012/03 Rosato, AE. “Mechanisms associated to Methicillin Resistant Staphylococcus aureus (MRSA) clinical strains: going beyond mecA gene” University of Texas, Department of Pathology and Laboratory Medicine, Houston, TX
University of Texas, Department of Pathology and Laboratory Medicine, Houston, TX
2011/08 Plata K, Rosato R and Rosato A. Modulation of ß-lactam resistance expression in MRSA by the accessory gene regulator agr. Gordon Conference in S. aureus.
2010/09 Mehta S, Silverman J, Rubio A, and Rosato A. Increased expression of the VraSR two-component regulator contributes to decreased susceptibility to daptomycin in-vivo selected MRSA clinical strains. International Symposium on Staphylococci and Staphylococcal Infections
2010/09 Mehta S, Silverman J, Rubio A, and Rosato A. Daptomycin resistance in MRSA clinical strains. 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
2008/10 Plata, K.; Cuirolo A. and Rosato A. Characterization of a ceftobiprole-resistant mutant selected in vitro from a clinical MRSA isolate 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
2005/08 Rosato, AE. Mechanism of ß-lactam dependence in a clinical S.aureus isolate Gordon Conferences, Staphylococcal Diseases
2001/12 Rosato A; Kreiswirth B, Craig W, Eisner W , Climo M., and Archer G. Identification and Characterization of mecA/blaZ Corepressors Among Clinical Staphylococcus aureus Isolates. 41th. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
1993/10 Rosato, A.; Pierre, J.; Buu-Hoi, A.; Collatz, E. and Gutmann, L. Low level glycopeptide resistance in Enterococcus avium. 33th. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
American society for microbiology

Association member

Society Organization name Role
2017 - Current Gulf Coast Consortia (GCC) Cluster for Antimicrobial Resistance (GCC AMR)
2004 - Current Present Member Core Investigator of NARSA (Network of Antimicrobial Resistance in S.aureus)

Consulting

Activity description Institution / Organization
2018/05 - Current Consultant in clinical studies/development a consultant of clinical studies, design of Phase I , II and III protocols.
2017 - Current Consultant at WHO- Pan American Health Organization (PAHO) –Antimicrobial Resistance Pan American Health Organization, United States
2016/03 - Current Consultant of WHO mission , design, planning and execution of National Plan of Antimicrobial Resistance.

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2017 - Current Grant Reviewer: ZRG1 IDM-Y 82S-DDR. Exploration of Antimicrobial Resistance Microbes and Antimicrobial Therapeutics.
Evaluator
2017 - Current Present Grant Reviewer: BACP (Bacterial Pathogenesis) NIAID.
Evaluator
2015 - Current Grant Reviewer- British Society of Antimicrobial Chemotherapy, UK
Evaluator
2015 - Current Grant Reviewer:-European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Evaluator
2013 - Current Grant Reviewer-Leadership Group for a Clinical Research Network on Antibacterial Resistance (UM1)
Evaluator
2012 - Current Grant Reviewer - French National Research Antimicrobial Resistance Agency
Evaluator
Agence nationale de la recherche, France
2012 - Current Grant Reviewer-Maryland Industrial Partnerships Program (MIPS) University of Maryland
Evaluator
University of Maryland Baltimore, United States
2012 - Current Grant Reviewer-The Portuguese Foundation for Science and Technology (FCT), Portugal
Evaluator
Fundação para a Ciência e a Tecnologia, Portugal
2011/02 - Current I serve as a grant reviewer for NIAID /NIH and I play a substantial role in grant funds decision for research project of national institutions working in the field of Antimicrobial Discovery and Resistance , as well as microbiology and pathogenesis of MDR . National Institutes of Health, United States
Distinctions

Award

2012 Journal highlights, Microbe Magazine (Best Publication of the year 2012)
American Society for Microbiology, United States
2008 Faculty Award, Outstanding service as a mentor of ASM Minorities
American Society for Microbiology, United States
2006 Faculty Award for Distinguished Research, VCU (Best Faculty based in research and NIH awards)
Virginia Commonwealth University, United States