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Rui Silva (Silva R) is currently a Junior Researcher at the Centre of Biological Engineering (CEB) - University of Minho and the Associate Director at the Molecular Biotechnology Laboratory (LBM). He holds a PhD degree in Chemical and Biological Engineering from the University of Minho (2019). His research focuses on the development of microbial cell factories using metabolic engineering approaches for the production of high-value chemicals by fermentation. During his PhD, he systematically characterized a filamentous fungus (Ashbya gossypii) at physiological, cellular and molecular level and designed strategies for its development as a cell factory. In 2017, he performed a scientific mission at University of Salamanca (Spain). To date, he is author of seven publications in international peer-reviewed journals, three oral communications and six poster communications in peer-reviewed scientific conferences. Additionally, Rui complemented his laboratory experience with training on innovation management (product development), entrepreneurship (intellectual property and regulation, market analysis and financial and funding strategy) and effective communication skills and public speaking. Since 2019, as Associate Director of LBM, Rui is directly involved in the management of the laboratory that receives 10+ researchers. He is also regularly involved in scientific outreach activities.
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Identification

Personal identification

Full name
RUI MIGUEL CORREIA DA SILVA

Citation names

  • SILVA, RUI

Author identifiers

Ciência ID
AA1D-2865-5DB1
ORCID iD
0000-0002-5803-0769
Scopus Author Id
56431966900

Email addresses

  • rsilva@ceb.uminho.pt (Professional)
  • rui.mcorreiasilva@gmail.com (Personal)

Telephones

Telephone
  • (+351) 253601973 (Professional)

Addresses

  • Centro de Engenharia Biológica (Universidade do Minho) - Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Industrial Biotechnology - Industrial Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Advanced (C1)
Spanish; Castilian Elementary (A2) Beginner (A1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2015/03 - 2019/09
Concluded
 Chemical and Biological Engineering (Doutoramento)
Universidade do Minho Escola de Engenharia, Portugal
"Designing synthetic Ashbya cell factories" (THESIS/DISSERTATION)
 Very good
2012/09 - 2014/12
Concluded
 Bioengineering (Mestrado)
Universidade do Minho Escola de Engenharia, Portugal
"Exploitation of Ashbya gossypii for the production of high-value products from glycerol feedstocks" (THESIS/DISSERTATION)
 18 (out of 20)
2009/09 - 2012/07
Concluded
 Biochemistry (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
 14 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2020/03/05 - Current Contracted Researcher (Research) Universidade do Minho Centro de Engenharia Biológica, Portugal
2019/10/01 - 2019/12/31 Postdoc (Research) Universidade do Minho Centro de Engenharia Biológica, Portugal
2015/10/01 - 2019/09/16 Researcher (Research) Universidade do Minho Centro de Engenharia Biológica, Portugal
2017/05 - 2017/07 Visiting Researcher (Research) Universidad de Salamanca, Spain

Positions / Appointments

Category
Host institution 		Employer
2019/05 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Universidade do Minho Centro de Engenharia Biológica, Portugal
Laboratory of Molecular Biotechnology, Portugal
Projects

Grant

Designation Funders
2019/10/01 - 2019/12/31 Development of new microbial production systems using advanced molecular biotechnology tools
UID/BIO/04469/2019
Research Fellow
Universidade do Minho Centro de Engenharia Biológica, Portugal
 Universidade do Minho Centro de Engenharia Biológica
Concluded
2015/10/01 - 2019/09/16 Designing synthetic Ashbya cell factories
PD/ BD/113812/2015
PhD Student Fellow
Universidade do Minho Centro de Engenharia Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2020/03/05 - Current BBRI - Biomass and Bioenergy Research Infrastructure
PINFRA/22059/2016
Researcher
Universidade do Minho Centro de Engenharia Biológica, Portugal
Ongoing
Outputs

Publications

Conference abstract
  1. SILVA, RUI; Tatiana Q. Aguiar; Lucília Domingues. "Towards the valorization of crude glycerol to high-value chemicals by engineered Ashbya gossypii (Oral Communication)". Paper presented in 7th Conference on Physiology of Yeasts and Filamentous Fungi (PYFF7), Milan, 2019.
    Published
  2. SILVA, RUI; Tatiana Q. Aguiar; Rui Oliveira; Lucília Domingues. "Ashbya gossypii riboflavin overproducing strains are highly susceptible to light-induced oxidative DNA damage (Oral Communication)". Paper presented in MICROBIOTEC’17 - Book of Abstracts, 61. Porto, Portugal, December 7-9, Porto, 2017.
    Published
  3. SILVA, RUI; Tatiana Q. Aguiar; Lucília Domingues. "Engineering osmotic stress tolerance in the riboflavin producer Ashbya gossypii (Oral Communication)". Paper presented in BIOIBEROAMÉRICA 2016 - Book of Abstracts, 494. Salamanca, Spain, June 5-8, Salamanca, 2016.
    Published
Conference poster
  1. SILVA, RUI; Eduardo Coelho; Tatiana Q. Aguiar; Alberto Jiménez; José Luis Revuelta; Lucília Domingues. "Volatile compounds’ profiling and engineering of Ashbya gossypii strains for de novo biosynthesis of lactones". Paper presented in Metabolic Engineering 12 - Munich, Germany, 2018.
  2. Tatiana Q. Aguiar; SILVA, RUI; Carla Oliveira; Lucília Domingues. "Substrate inhibition of uracil phosphoribosyltransferase (UPRT) in distinct microbial species and its implications in the phenotype of uracil auxotrophs". Paper presented in ” MICROBIOTEC’17 - Porto, Portugal, 2017.
  3. SILVA, RUI; Rui Oliveira; Tatiana Q. Aguiar; Lucília Domingues. "The Ashbya gossypii Comet Assay: measuring oxidative and non-oxidative damage in the DNA". Paper presented in 30 years Molecular Biology of Ashbya gossypii - Basel, Switzerland, 2017.
  4. SILVA, RUI; Tatiana Q. Aguiar; Lucília Domingues. "Deciphering the uracil growth sensitivity of Ashbya gossypii pyrimidine auxotrophs". Paper presented in 30 years Molecular Biology of Ashbya gossypii - Basel, Switzerland, 2017.
  5. SILVA, RUI; Tatiana Q. Aguiar; Lucília Domingues. "Why does uridine supplementation properly rescues the growth of Ashbya gossypii uracil auxotrophs, but not uracil?". Paper presented in XIX National Congress of Biochemistry - Guimarães, Portugal, 2016.
  6. SILVA, RUI. "Analysis of the sensitivity of different fungal species to uracil". Paper presented in PYFF6 - 6th Conference on Physiology of Yeast and Filamentous Fungi - Lisbon, Portugal, 2016.
Journal article
  1. David Díaz-Fernández; Tatiana Q. Aguiar; Victoria Isabel Martín; Aloia Romaní; SILVA, RUI (AA1D-2865-5DB1); Lucília Domingues; José Luis Revuelta; Alberto Jiménez. "Microbial lipids from industrial wastes using xylose-utilizing Ashbya gossypii strains". Bioresource Technology 293 (2019): 122054-122054. https://doi.org/10.1016/j.biortech.2019.122054.
    10.1016/j.biortech.2019.122054
  2. SILVA, RUI (AA1D-2865-5DB1); Tatiana Q. Aguiar; Carla Oliveira; Lucília Domingues. "Physiological characterization of a pyrimidine auxotroph exposes link between uracil phosphoribosyltransferase regulation and riboflavin production in Ashbya gossypii". New Biotechnology 50 (2019): 1-8. https://doi.org/10.1016/j.nbt.2018.12.004.
    10.1016/j.nbt.2018.12.004
  3. SILVA, RUI (AA1D-2865-5DB1); Aguiar, Tatiana Q.; Coelho, Eduardo; Jiménez, Alberto; Revuelta, José Luis; Domingues, Lucília. "Metabolic engineering of Ashbya gossypii for deciphering the de novo biosynthesis of y-lactones". Microbial Cell Factories 18 1 (2019): http://dx.doi.org/10.1186/s12934-019-1113-1.
    10.1186/s12934-019-1113-1
  4. SILVA, RUI (AA1D-2865-5DB1); Tatiana Q. Aguiar; Rui Oliveira; Lucília Domingues. "Light exposure during growth increases riboflavin production, reactive oxygen species accumulation and DNA damage in Ashbya gossypii riboflavin-overproducing strains". FEMS Yeast Research (2019): https://academic.oup.com/femsyr/advance-article-abstract/doi/10.1093/femsyr/foy114/5129140?redirectedFrom=fulltext.
    doi.org/10.1093/femsyr/foy114
  5. Aguiar, T.Q.; SILVA, RUI (AA1D-2865-5DB1); Domingues, L.. "New biotechnological applications for Ashbya gossypii: Challenges and perspectives". Bioengineered 8 4 (2017): 309-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992482230&partnerID=MN8TOARS.
    10.1080/21655979.2016.1234543
  6. SILVA, RUI (AA1D-2865-5DB1); Tatiana Q. Aguiar; Lucília Domingues. "Blockage of the pyrimidine biosynthetic pathway affects riboflavin production in Ashbya gossypii". Journal of Biotechnology (2015): https://www.sciencedirect.com/science/article/pii/S0168165614009730.
    10.1016/j.jbiotec.2014.11.009
  7. Aguiar, T.Q.*; SILVA, RUI (AA1D-2865-5DB1)*; Domingues, L.. "Ashbya gossypii beyond industrial riboflavin production: A historical perspective and emerging biotechnological applications". Biotechnology Advances 33 8 (2015): 1774-1786. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951046225&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2015.10.001
Thesis / Dissertation
  1. SILVA, RUI. "Designing synthetic Ashbya cell factories". PhD, Universidade do Minho Centro de Engenharia Biológica, 2019. http://hdl.handle.net/1822/66077.
  2. SILVA, RUI. "Exploitation of Ashbya gossypii for the production of high-value products from glycerol feedstocks". Master, Universidade do Minho Centro de Engenharia Biológica, 2014. http://hdl.handle.net/1822/41689.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/03/10 The filamentous fungus Ashbya gossypii as an alternative cell factory Seminário da Unidade Curricular de Biotecnologia Microbiana do Mestrado Integrado em Ciências Farmacêuticas
Faculdade de Farmácia da Universidade Porto (Porto, Portugal)
2020/02/19 Diversifying beyond Saccharomyces cerevisiae: the engineering potential of the filamentous fungus Ashbya gossypii for biomass-based products and energy 1st Workshop of BBRI – Biomass and Bioenergy Research Infrastructure
LNEG - Laboratório Nacional de Energia e Geologia (Lisbon, Portugal)
2020/02/11 The filamentous fungus Ashbya gossypii as an alternative cell factory 8th Workshop of the Doctoral Program in Applied and Environmental Microbiology
IB-S (Institute of Science And Innovation for Bio-Sustainability) - Universidade do Minho (Braga, Portugal)
2019/06/24 Towards the valorization of crude glycerol to high-value chemicals by engineered Ashbya gossypii 7th Conference on Physiology of Yeasts and Filamentous Fungi (PYFF7)
University of Milano Bicocca (Milan, Italy)
2018/07/11 Improved de novo biosynthesis of lactones by engineered Ashbya gossypii 3rd Joint BIOTECnico and AEM PhD Programs Workshop
Instituto Superior Técnico (Lisbon, Portugal)
2017/09/25 Designing synthetic Ashbya cell factories 2nd Joint Workshop of the PhD Programs In Applied and Environmental Microbiology (DP_AEM) and Molecular and Environmental Biology (PDBMA)
Universidade do Minho (Braga, Portugal)
2017/02/15 Designing synthetic terpenoid-producing fungal cell factories: Metabolic profiling of aroma volatile compounds produced by Ashbya gossypii wild strains 2nd Joint BIOTECnico and AEM PhD Programs Workshop
Instituto Superior Técnico (Lisbon, Portugal)
2016/01/21 Ashbya gossypii beyond industrial riboflavin production: A historical perspective and emerging biotechnological applications. 1st Joint BIOTECnico and AEM PhD Programs Workshop
Instituto Superior Técnico (Lisbon, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/12 - 2019/12 OUTREACH ACTIVITY "O Melhor Estudante na UMinho"
Universidade do Minho, Portugal
2019/09 - 2019/12 OUTREACH ACTIVITY "Pequenos Cientistas" - 2 events
Associação Moinho de Vermoim, Portugal
2019/11 - 2019/11 OUTREACH ACTIVITY "Semana C&T"
Universidade do Minho, Portugal
2019/07 - 2019/07 OUTREACH ACTIVITY "Verão no Campus"
Universidade do Minho, Portugal
2019/05 - 2019/05 OUTREACH ACTIVITY "Cientificamente Provável"
Universidade do Minho, Portugal
2019/05 - 2019/05 OUTREACH ACTIVITY "ExpoBiotec’19"
Universidade do Minho, Portugal
2018/11 - 2018/11 OUTREACH ACTIVITY "Open Day CEB"
Universidade do Minho Centro de Engenharia Biológica, Portugal
2018/06 - 2018/06 OUTREACH ACTIVITY "Verão no Campus"
Universidade do Minho, Portugal
2016/09 - 2017/07 Effective Communication and Public Speaking
Workshop
 Effective Communication and Public Speaking
Universidade do Minho, Portugal
2016/07 - 2016/07 OUTREACH ACTIVITY "Verão no Campus"
Universidade do Minho, Portugal
2016/04 - 2016/04 OUTREACH ACTIVITY "QUALIFICA 2016" - EXPONOR, Porto
Fundação para a Ciência e a Tecnologia, Portugal

Association member

Society Organization name Role
2019 - Current Portuguese Society of Microbiology (SPM) Member
2019 - Current National Association of Science and Technology Researchers (ANICT) Member
2016 - Current Portuguese Society of Biotechnology (SPBT) Member

Consulting

Activity description Institution / Organization
2015 - 2019 Voluntary assistant in the Molecular Biotechnology course - Module “Planning and in silico simulation of molecular cloning” of the MSc in Bioengineering and integrated MSc in Biological Engineering (5 different classes). Universidade do Minho Escola de Engenharia, Portugal