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After my graduation in Biotechnological Engineering in 2003, I joined the Center for Neuroscience of Coimbra (CNC, Coimbra, Portugal) to develop my MSc thesis, where I characterized the signal transduction pathways involved in the yeast¿s response to several stresses. This raised yeasts as a basic model to study inflammatory/stress responses at the cellular level and to assist in the search/screening of new anti-inflammatory drugs (1 first author publication in J. Biol. Chem. and 2 co-author publications). In 2006, I joined J Lerma¿s lab (Instituto de Neurociencias, Alicante, Spain) to perform my PhD in neuroscience, where I could provide the first link between activity, i.e. glutamate, and neurocytoskeleton dynamics during neuronal development, raising kainite receptor as the key tether linking synaptic contact formation and neuronal maturation. This represented a breakthrough in brain development. These results were published in J. Neuroscience (first author publication awarded with Best Paper 2014 award by Portuguese Society for Neurosciences) and reviewed in Neuron. In 2013 I joined RJ Rodrigues¿ lab at CNC (Coimbra, Portugal) to explore the pathological role of purinergic and glutamate receptors in brain diseases. I contributed to determine that P2Y1R contributes to glutamate-induced neurodegeneration (Simões et al., 2018) and to synaptic and memory loss in Alzheimer¿s disease models (co-first author manuscript in preparation; see Marques et al., 2017), raising the concept that this newly identified pathway may constitute a degenerative mechanism shared by different brain diseases. This work was supported by an international grant from Alzheimer's Association (NIRG-15-361884) in which I was Co-PI. I have been also exploring the existence of hybrid P2X/GluN receptors, establishing a new receptor concept (manuscript under revision; Postdoctoral fellowship SFRH/BPD/107903/2015). I also contributed to 9 co-author publications on the physio-pathological role of purinergic signalling. I also started my transition towards my scientific independency by exploring a new line of investigation dedicated to explore brain diseases from the perspective of brain development, merging my interest/expertise in brain development (PhD) and disease (postdoc). This has been successfully accomplished, attested by the attribution of CEEC Individual 2017 (Junior level) and of my first grant as a PI (PTDC/MED-NEU/28160/2017; 238,834¿). Also, I supervised 3 graduation (2015, 2018, 2019), 2 MSc thesis (2018 and 2019) and 1 PhD student, and participated in teaching in post-graduate programs (e.g. GABBA PhD programme). I already constituted a small group that is presently composed by 1 senior researcher, 1 PhD and 1 MSc students. Our independent research activity supports already two manuscripts in preparation as last author and 2 review papers.
Identification

Personal identification

Full name
Joana Medeiros Vieira Marques
Date of birth
1977/03/03
Gender
Female

Citation names

  • Marques, Joana
  • Joana M Marques

Author identifiers

Ciência ID
8F1D-1D21-457C
ORCID iD
0000-0002-7234-9477
Scopus Author Id
55888289600

Email addresses

  • joanammarques@gmail.com (Professional)

Addresses

  • Center for Neuroscience and Cell Biology Faculdade de Medicina, Polo I, Rua Larga , 3004-504, Coimbra, Coimbra, Portugal (Professional)
  • Rua Nuno Tristão nº10, 3030-066, Coimbra, Coimbra, Portugal (Personal)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1109&idgrp=1408&IdGrupo=1107&IdSeccao=&hash=39 (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2)
French Elementary (A2) Elementary (A2) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2013/10/31
Concluded
Biology (Doutoramento)
Major in Cell Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Role of kainate receptors in neuronal development." (THESIS/DISSERTATION)
Aprovada com Distinção e Louvor por Unanimidade
2006/11/02
Concluded
MSc in Celular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Involvement of Hog1 protein in the Saccharomyces cerevisiae response to lipopolysaccharide." (THESIS/DISSERTATION)
Very Good
2003/02/19
Concluded
Biotechnology Engineering (Licenciatura)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
"Metabolic alterations in yeast apoptosis." (THESIS/DISSERTATION)
14
Affiliation

Others

Category
Host institution
Employer
2019/04/01 - Current CEECIND 2017 Junior Investigator (01879) FCT- Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/07/05 - 2021/12/31 Investigator - Project Principal Investigator - POCI-01-0145-FEDER-028160- "A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis" FCT- Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/06 - 2018/06 Postdoctoral fellowship FCT- Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/11 - 2016/05 Project Investigator Alzheimer's Association, United States
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/05 - 2015/08 Postdoctoral fellowship Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/05 - 2011/12 PhD fellowship FCT- Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Neurociencias de Alicante Laboratorio Synaptic Physiology, Spain
2006/08 - 2007/05 Project Investigator Consejo Superior de Investigaciones Científicas, Spain
Instituto de Neurociencias de Alicante CSIC-UMH, Spain
2003 - 2006 Project Investigator Fundação para a Ciência e a Tecnologia, I.P., Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2019 - Current CEECIND2017-A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis.
01879
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
FCT- Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021/12/31 A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis
PTDC/MED-NEU/28160/2017
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
FCT- Fundação para a Ciência e a Tecnologia
Ongoing
2015 - 2017/01 P2Y1 Receptor-CRMP2 Control Synaptic Loss and Memory Impairment in Early Alzheimer’s Disease Alzheimer's Association
2007 - 2011/12 Role of kainate receptors in neuronal maturation, navigation and synaptogenesis
SFRH / BD / 27517 / 2006
PhD Student Fellow
Instituto de Neurociencias de Alicante CSIC-UMH, Spain
FCT- Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2016 - 2018/06 Hybrid ionotropic receptors: a new concept of receptor
PTDC/NEU-NMC/3567/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
FCT- Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2017/01 P2Y1 Receptor-CRMP2 Control Synaptic Loss and Memory Impairment in Early Alzheimer’s Disease
NIRG-15-361884
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Alzheimer's Association
Concluded
2013 - 2014/04 Role of P2Y1 receptors on neuronal polarity and axonal growth: implications for mossy fiber sprouting in epileptic phenomena.
FCT-EXPL/NEU-NMC/0671/2012
FCT-EXPL/NEU-NMC/0671/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
Outputs

Publications

Conference poster
  1. "Cortical interneurons migration entails motogenic action of P2Y1 receptor and guidance by P2X1 receptor.". Paper presented in SPN 2021 meeting, 2021.
  2. "Status epilepticus-induced hippocampal mossy fiber sprouting requires adenosine A2A receptor.". Paper presented in SPN 2021 meeting, 2021.
  3. "Adenosine A2A receptor contributes to hippocampal mossy fiber sprouting during epileptogenesis.". Paper presented in FENS 2020 Virtual Forum, 2020.
  4. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Leyva-Diaz, E; Rocha, JMM; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2 receptors control the migration of medial ganglionic eminence-derived interneurons". Paper presented in SPN2019 meeting, 2019.
    10.1259/conf-pukrc.2017.poster-abs
  5. Xu, Xinli; Alçada-Morais, S; Rocha, JMM; Ferreira, Sofia; Beleza, RO; Cunha, RA; Rodrigues, RJ; Joana M Marques. "Adenosine A2A receptor contributes to hippocampal mossy fiber sprouting during epileptogenesis". Paper presented in SPN2019 meeting, Lisbon, Portugal, 2019.
    10.1259/conf-pukrc.2017.poster-abs
  6. Alçada-Morais, S; Rocha, JMM; Moreno-Juan, V; Gonçalves, Nélio; Andreas, B; Ferreira, Sofia; Joana M Marques; et al. "Cortical Neuron migration entails A2A receptor-driven neuronal polarization and axon formation". Paper presented in SPN2019 meeting, Lisbon, Portugal, 2019.
    10.1259/conf-pukrc.2017.poster-abs
  7. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Leyva-Diaz, E; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2 receptors control the migration of medial ganglionic eminence-derived interneurons". Paper presented in ISN-ESN MEETING 2017, Paris, France, 2017.
    10.1259/conf-pukrc.2017.poster-abs
  8. Rodrigues, RJ; Alçada-Morais, S; Leyva-Diaz, E; Moreno-Juan, V; Gonçalves, Nélio; Andreas, B; Ferreira, Sofia; et al. "Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation". Paper presented in ISN-ESN MEETING 2017, Paris, France, 2017.
    10.1259/conf-pukrc.2017.poster-abs
  9. Joana M Marques; Canas, PM; Porciúncula, LO; Queiroz, F; Xu, Xinli; Silva, CG; Fernandes, Beatriz; et al. "P2Y1 receptor is required for Aß-induced synaptic loss, plasticity deficits and memory impairment". Paper presented in ISN-ESN MEETING 2017, Paris, France, 2017.
    10.1259/conf-pukrc.2017.poster-abs
  10. Alçada-Morais, S; Xu, Xinli; Joana M Marques; Gonçalves, Nélio; Ferreira, Sofia; Beleza, RO; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors control axon formation during neuronal development: implications to neuronal migration and epileptogenesis". Paper presented in 7th ISN Special Conference of Neurochemistry, Coimbra, Portugal, 2016.
    10.1259/conf-pukrc.2017.poster-abs
  11. Ferreira, Sofia; Marques, JM; Alçada-Morais, S; Leyva-Diaz, E; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2Y1 receptors control the migration of medium ganglionic eminence-derived interneurons". Paper presented in 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016.
    10.1109/cca.2012.6402731
  12. Alçada-Morais, S; Ferreira, Sofia; Gonçalves, Nélio; Beleza, RO; Joana M Marques; Xu, Xinli; Andres, B; et al. "Adenosine A2A receptors control cortical neuronal migration". Paper presented in 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016.
    10.1259/conf-pukrc.2017.poster-abs
  13. Pinheiro, BS; Lemos, C; Joana M Marques; Neutzling-Kaufmann, F; da Silva-Santos, CS; Rodrigues, RJ; Cunha, RA; Köfalvi, A. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the metabolic state-dependent activation of the nucleus accumbens by insulin". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  14. Xu, Xinli; Alçada-Morais, S; Joana M Marques; Ferreira, Sofia; Beleza, RO; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors induce the formation of abnormal secondary axons in rat hippocampal neurons: a new target to arrest epileptogenesis". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  15. Alçada-Morais, S; Ferreira, Sofia; Gonçalves, Nélio; Beleza, RO; Joana M Marques; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors control cortical neurons migration". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  16. Rodrigues, RJ; Aller, MI; Palacios, J; Joana M Marques; Cunha, RA; Lerma, J. "P2X2/GluN2B hybrid receptors: a new concept of receptor". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.4271/2001-24-0033
  17. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Cunha, RA; Rodrigues, RJ. "P2Y1 receptor promotes the migration of medial ganglionic eminence-derived interneurons". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  18. Joana M Marques; Rodrigues, RJ; Aller, MI; Lerma, J. "Kainate receptors induce axon formation and outgrowth in mice hippocampal neurons". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  19. Simões, AP; Silva, CG; Pochmann, D.; Joana M Marques; Oses, JP; Beleza, RO; Cunha, RA; Rodrigues, RJ. "Neuronal P2Y1 receptors are required for NMDAR-induced, calpain-mediated synaptic loss and neuronal death". Paper presented in 9th FENS Forum of Neuroscience, Milan, Italy, 2014.
    10.1259/conf-pukrc.2017.poster-abs
  20. Beleza, RO; Ferreira, Sofia; Alçada-Morais, S; Joana M Marques; Cunha, RA; Rodrigues, RJ. "Purinergic signaling is essential for proper neuronal polarization". Paper presented in XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  21. Porciúncula, LO; Silva, CG; Canas, PM; Joana M Marques; Andrade, GM; Oses, JP; Gachet, C; Cunha, RA; Rodrigues, RJ. "P2Y1 receptor is involved in Abeta-induced synaptic and memory loss". Paper presented in XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  22. Rodrigues, RJ; Porciúncula, LO; Canas, PM; Silva, CG; Joana M Marques; Andrade, GM; Oses, JP; Gachet, C; Cunha, RA. "P2Y1 receptor is involved in Abeta-induced synaptic and memory loss". Paper presented in 43rd Annual Meeting of the Society for Neuroscience, San Diego, USA, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  23. Joana M Marques; Rodrigues, RJ; Valbuena, S; Rozas, JL; Selak, S; Marin, P; Aller, MI; Lerma, J. "CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development". Paper presented in 43rd Annual Meeting of the Society for Neuroscience, San Diego, USA, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  24. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Paper presented in XII meeting of the Portuguese Neuroscience Society, Lisbon, Portugal, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  25. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Paper presented in 8th world congress of International Brain Research Organization, Florence, Italy, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  26. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Paper presented in XIV Congreso Nacional de la Sociedad Española de Neurociencias, Salamanca, Spain, 2011.
  27. Rodrigues, RJ; Joana M Marques; Aller, MI; Lerma, J. "Kainate receptors modulate axonal outgrowth and neuronal polarity through the control of CRMP2 function". Paper presented in XIV Congreso Nacional de la Sociedad Española de Neurociencias, Salamanca, Spain, 2011.
    10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2146
  28. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Aller, MI; Lerma, J. "Bidirectional modulatory role of kainate receptors on neuronal maturation". Paper presented in 41st Annual Meeting of the Society for Neuroscience, Washington D.C., USA, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  29. Rodrigues, RJ; Joana M Marques; Aller, MI; Lerma, J. "Kainate receptors modulate axonal outgrowth and neuronal polarity in mice hippocampal neurons through the control of CRMP2 function". Paper presented in 41st Annual Meeting of the Society for Neuroscience, Washington D.C., USA, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  30. Paulo, C; Joana M Marques; Mourão, C; Nogueira, C; Alves, M; Meliço-Silvestre, A; Alves, AF; Quintas, C; Gonçalves, Teresa. "Understanding yeast infections epidemiology: a revision of the diagnosis/identification procedures applied to the Portuguese population". Paper presented in 3rd Trends in Medical Mycology, Turin, Italy, 2007.
    10.1259/conf-pukrc.2017.poster-abs
  31. Joana M Marques; Rodrigues, RJ; Gonçalves, Teresa. "Characterization of S. cerevisiae Hog1 protein activation upon bacterial LPS-exposure". Paper presented in XXIInd International Conference on Yeast Genetics and Molecular Biology, Bratislava, Slovaquia, 2005.
  32. Gonçalves, Teresa; Oliveira, AP; Joana M Marques; McCance, D; de Magalhães-Sant'Ana, AC; Santos, P.; Regateiro, F; Castro, IM. "Saccharomyces cerevisiae stress resistance patterns upon HPV16.E6 expression". Paper presented in 25th International Specialized Symposium on Yeasts, Oropesa del Mar, Spain, 2005.
    10.1259/conf-pukrc.2017.poster-abs
  33. Joana M Marques; Gonçalves, Teresa. "Functional Characterization of Hog1 p response upon treatment with p38 animal cell protein activators". Paper presented in 23rd International Specialised Symposium on Yeasts, Budapest, Hungary, 2003.
    10.1259/conf-pukrc.2017.poster-abs
  34. Joana M Marques; Gonçalves, Teresa. "Yeast thermal death: metabolic alterations due to an apoptotic-like process". Paper presented in III Congresso de Investigação em Medicina, Coimbra, Portugal, 2002.
    10.1259/conf-pukrc.2017.poster-abs
  35. Joana M Marques; Gonçalves, Teresa. "Yeast thermal death: metabolic alterations due to an apoptotic-like process". Paper presented in XIII Congresso Nacional de Bioquímica, Lisbon, Portugal, 2002.
    10.1259/conf-pukrc.2017.poster-abs
Journal article
  1. Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães, Joana; et al. "Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation". Cerebral Cortex 31 12 (2021): 5652-5663. http://dx.doi.org/10.1093/cercor/bhab188.
    10.1093/cercor/bhab188
  2. Joana M Marques. "Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders". Journal of Caffeine and Adenosine Research (2019): http://dx.doi.org/10.1089/caff.2019.0010.
    10.1089/caff.2019.0010
  3. Joana M Marques. "Purinergic signalling and brain development". Seminars in Cell & Developmental Biology (2019): http://dx.doi.org/10.1016/j.semcdb.2018.12.001.
    10.1016/j.semcdb.2018.12.001
  4. Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell Death and Disease 9 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS.
    10.1038/s41419-018-0351-1
  5. Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin". Brain Research Bulletin 124 (2016): 222-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971467088&partnerID=MN8TOARS.
    10.1016/j.brainresbull.2016.05.009
  6. Rodrigues, R.J.; Almeida, T.; Díaz-Hernández, M.; Marques, J.M.; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A.. "Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus". Neuropharmacology 105 (2016): 241-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961368309&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2016.01.022
  7. Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al. "High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus". Neuroscience 315 (2016): 196-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952911994&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2015.12.018
  8. Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Marques, J.M.; Rodrigues, R.J.; Cunha, R.A.; Rial, D.; Köfalvi, A.. "Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain". Purinergic Signalling 11 4 (2015): 561-569. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947618042&partnerID=MN8TOARS.
    10.1007/s11302-015-9474-3
  9. Ferreira, S.G.; Gonc¸alves, F.Q.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; et al. "Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission". British Journal of Pharmacology 172 4 (2015): 1074-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS.
    10.1111/bph.12970
  10. Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al. "Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus". European Journal of Neuroscience 41 7 (2015): 876-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926407234&partnerID=MN8TOARS.
    10.1111/ejn.12851
  11. Lerma, J.; Marques, J.M.. "Kainate receptors in health and disease". Neuron 80 2 (2013): 292-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885732604&partnerID=MN8TOARS.
    10.1016/j.neuron.2013.09.045
  12. Marques, J.M.; Rodrigues, R.J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J.. "CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation". Journal of Neuroscience 33 46 (2013): 18298-18310. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887382896&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3136-13.2013
  13. Paulo, C.; Mourão, C.; Veiga, P.M.; Marques, J.M.; Rocha, G.; Alves, A.F.; Querol, A.; et al. "Retrospective analysis of clinical yeast isolates in a hospital in the centre of Portugal: Spectrum and revision of the identification procedures". Medical Mycology 47 8 (2009): 836-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-73649102062&partnerID=MN8TOARS.
    10.3109/13693780802709081
  14. Marques, J.M.; Rodrigues, R.J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T.. "Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin". Journal of Biological Chemistry 281 34 (2006): 24687-24694. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS.
    10.1074/jbc.M603753200
  15. Pinto-De-Oliveira, A.; McCance, D.; De Magalhães-Sant'Ana, A.C.; Marques, J.M.; Gonçalves, T.. "Expression of HPV16 E6 oncoprotein increases resistance to several stress conditions in Saccharomyces cerevisiae". FEMS Yeast Research 5 8 (2005): 777-787. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644383654&partnerID=MN8TOARS.
    10.1016/j.femsyr.2005.02.002
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10/18 Purinergic receptors control neuronal migration during corticogenesis Sinal Meeting
(Olhão, Portugal)
2019/09/05 Cortical principal neurons migration entails A2AR-driven neuronal polarization and axon formation
(Santiago de Compostela, Spain)
2017 Neuronal migration: a critical journey for a healthy brain. XLVI Conferências de Genética Doutor Jacinto Magalhães – Neurogenética Pediátrica, Porto, Portugal
2016 Role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons XLVI Meeting of the Portuguese Society for Pharmacology, Porto, Portugal
2016 Adenosine A2a receptors control cortical neurons migration XLVI Meeting of the Portuguese Society for Pharmacology, Porto, Portugal
2016 P2Y1 receptors control the migration of medium ganglionic eminence-derived interneurons Brain Without Borders meeting, Coimbra, Portugal
2016 Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation XV meeting SPN 2017, Minho, Portugal
2014 Adenosine A2A receptors influence the establishment of neuronal polarity of rat hippocampal neurons XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2014 The bidirectional modulation of axonal outgrowth of rat hippocampal neurons by P2 receptors should involve a differential regulation of CRMP2 protein XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2014 P2Y1R is required for Aß-induced synaptic and memory loss most likely by contributing to the phosphorylation of CRMP2 XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2013 CRMP2 thethers kainate receptor activity to cytoskeleton dynamics during development XLIII annual meeting of Portuguese Society for Pharmacology, Porto, Portugal
2013 CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal
2013 P2Y1 receptor is involved in Abeta-induced synaptic and memory loss 27th Meeting of the Grupo de Estudos do Envelhecimento Cerebral e Demência, Coimbra, Portugal
2013 CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development
IBMC, Porto, Portugal

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019/03 - 2019/07 Role of P2Y1R in the regulation of NMDARS in an heterologous expression system.
Co-supervisor of Diana Filipa Ribeiro e Silva Maciel Lourenço
Biologia (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03 - 2019/07 Optimization of 3D medial ganglionic eminence explant cultures for evaluation of interneuron migration.
Supervisor of Matilde Maria Cabral Neves Afonso
Biologia (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth
Supervisor of João Miguel Miranda da Rocha
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/02 - 2018/07 Characterization of the Abeta-1-42-induced modification in the phosphorylation of CRMP2 in mice hippocampal neurons.
Supervisor of Sara Patrícia Morais de oliveira Jorge Dias
Bioquímica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/03 - 2018/02 Characterization of Abeta-induced P2Y1 receptor-mediated phosphylation of CRMP2
Supervisor of Valentina Ruggiero
Science and Genetic Technologies (Master)
Università degli Studi del Sannio, Italy
2015/03 - 2015/12 Characterization of glutamate-induced modifications in CRMP2 protein in rat hippocampal neurons
Supervisor of José Alexandre Garcia Marinho da Silva
Biotecnologia (Degree)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/02 - Current Dia Internacional das Mulheres e Raparigas na Ciência 2022
Seminar
2016/04 - Current Category C for design and coordination of projects involving animal handling and experimentation by Direcção Geral de Alimentação Veterinária, Ministério da Agricultura e Veterinária, Portugal
2019/03 - 2019/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “2º Jardim-Escola João de Deus de Coimbra
2017/11 - 2017/11 Science & Technology week promoted by the science communication office of CNC- activities in “2º Jardim-Escola João de Deus de Coimbra
2017/03 - 2017/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “2º Jardim-Escola João de Deus de Coimbra
2016/03 - 2016/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “APPACDM de Coimbra” and in “2º Jardim-Escola João de Deus de Coimbra
2015/03 - 2015/03 Brain Awareness Week promoted by the science communication office of CNC- activities in “Forum Coimbra
2015/03 - 2015/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “APPACDM de Coimbra
2014/03 - 2014/03 Brain Awareness Week promoted by the science communication office of CNC- seminar in “Escola Profissional de Ourém
2014/03 - 2014/03 Brain Awareness Week promoted by the science communication office of CNC- activities with students in “2º Jardim-Escola João de Deus de Coimbra
2013/03 - 2013/03 Brain Awareness Week promoted by the science communication office of CNC – Seminar in “Escola Secundária de Pombal
2007/12 - 2007/12 Category B for laboratory animal handling and experimentation by Conselleria d’Agricultura, Pesca I Alimentació de la Generalitat Valenciana (2007/CAE/B/0002), Spain

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013/07/01 - 2013/07/05 Integrins, rhoGTPases and cytoskeleton, GABBA-PhD program 2013 course GABBA-PhD program 2013 (Doutoramento) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/06/16 A Saúde no Saber- Crónica Ilustrada Jornal Público

Interview (tv / radio show)

Program Topic
2018/07/15 - 2018/07/28 EUG2018 (European University Games 2018) Physical exercise and Brain Development
Distinctions

Award

2014 Best Paper in Cellular and Molecular Neurobiology 2014

Other distinction

2013 Featured Article
2011 Travel Grant - IBRO
2011 Travel Grant - Portuguese Neuroscience Society
2005 Grant - International Conference on Yeast Genetics and Molecular Biology