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Hugo Alexandre Louro Filipe completed the PhD in Chemistry - specialization in Biological Chemistry in 2014 by the Faculty of Sciences and Technology of the University of Coimbra. H. Filipe completed also the MSc in Chemistry - specialization in Advanced Chemistry in 2009 and the Graduation in Chemistry in 2006 by the same University. The PhD of H. Filipe complemented his experimental background with expertise in simulation of biological systems using molecular and kinetic modelling techniques. In the last years, H. Filipe developed the detailed characterization of biomolecular systems, at atomistic and coarse-grained level, focusing on the interaction of drug-like molecules with biological barriers. He makes use of molecular dynamics simulations to obtain the equilibrium and kinetic characterization of the interaction of drug-like molecules with lipid bilayers and proteins, such as efflux transporters, acting on the permeation of molecules through physiological barriers. In particular, he makes important methodological developments in the correct determination of free energy profiles for the interaction of molecules with lipid bilayers. He also developed mechanistic kinetic models where, by inclusion of the relevant parameters, it is possible to predict experimental observables. Currently, H. Filipe is a Coordinating Researcher in Instituto Politécnico da Guarda, developing his research work in the area of Biotechnology. H. Filipe taught two disciplines of the Medicinal Biotechnology degree at IPG. Also, he is Vogal of the Fiscal Council of the Portuguese Biophysics Society. H. Filipe has several active national and international collaborations, with theoretical and experimental groups. The close collaboration with experimental groups is very important to correctly define the modelling systems, and to translate theoretical results into applicability. In some numbers: H. Filipe published 19 articles in journals and 1 section of books. Organized 18 events. Participated in 26 events. Co-supervised 1 work of discipline for a PhD thesis. Supervised 1 MSc dissertation and co-supervised 5. Co-supervised 6 final works of LSc/BSc. Has received 9 awards and/or honours. H. Filipe participates and/or participated as Principal investigator in 3 projects, and had different roles in 19 other projects. H. Filipe was opponent in the Jury of 2 academic degrees. In their professional activities he interacted with dozens of collaborators in co-authorship of scientific papers. These numbers, namely those referring to project leadership, project participation and supervision activities represent the continuous development of a scientific independent career by H. Filipe.
Identification

Personal identification

Full name
Hugo Alexandre Louro Filipe

Citation names

  • Filipe, Hugo
  • Hugo A. L. Filipe
  • Filipe HAL

Author identifiers

Ciência ID
7F1D-7466-10FA
ORCID iD
0000-0001-6935-4307
Google Scholar ID
https://scholar.google.pt/citations?user=sb7ucSUAAAAJ&hl=en
Researcher Id
S-6488-2018
Scopus Author Id
37090411300

Email addresses

  • hlfilipe@ipg.pt (Professional)
  • hugolourofilipe@gmail.com (Personal)

Addresses

  • Unidade de Investigação para o Desenvolvimento do Interior (UDI/IPG) Av. Dr. Francisco de Sá Carneiro, 6300-559, Guarda, Guarda, Portugal (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Italian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2014/12/12
Concluded
Doutoramento em Química - Ramo de especialização em Química Biológica (Doutoramento)
Major in Química Biológica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Following Amphiphilic Molecules on Their Way through Lipid Membranes: Development of a Kinetic Model of Passive Permeation through the Blood-Brain Barrier" (THESIS/DISSERTATION)
Aprovado com distinção e Louvor
2009/07/23
Concluded
Mestrado em Química - Ramo de especialização em Química Avançada (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Quantitative Modeling of Passive Permeation through the Blood-Brain Barrier" (THESIS/DISSERTATION)
17 Values
2006/09/22
Concluded
Licenciatura em Química (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mixtures of Hydrophobically Modified Polyelectrolytes and Cyclodextrins, and Vesicles and Lamellar phases in Nonionic Surfactant Systems" (THESIS/DISSERTATION)
15 Values
Affiliation

Science

Category
Host institution
Employer
2021/09/01 - Current Coordinating Researcher (Research) Instituto Politécnico da Guarda, Portugal
2018/12/19 - 2021/07/01 Postdoc (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2018/06/19 - 2018/12/18 Postdoc (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
2017/06/19 - 2018/06/18 Postdoc (Research) CNC.IBILI, Portugal
2016/10/17 - 2017/06/16 Postdoc (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
2015/10/07 - 2016/10/06 Postdoc (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2014/07/01 - 2015/03/31 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal

Others

Category
Host institution
Employer
2018/12/19 - 2021/07/01 Posdoctoral Fellow - Colloids and Innovative Materials Group (Colling) - in charge of all computational activities developed by the group. Universidade de Coimbra, Portugal
2010/05/01 - 2014/12/12 PhD student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/02/01 - 2012/04/30 Short visit to the Laboratory of Prof. Ilpo Vattulainen Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/05/01 - 2010/04/30 Research Fellow Universidade de Coimbra Centro de Química de Coimbra, Portugal
2005/09/01 - 2007/02/28 Training Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006/09/15 - 2006/12/15 Erasmus student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Università degli Studi della Calabria Dipartimento di Fisica, Italy
Projects

Grant

Designation Funders
2010 - 2014/04/30 DEVELOPMENT AND EXPERIMENTAL VALIDATION OF A MATHEMATICAL MODEL OF PASSIVE PERMEATION THROUGH THE BLOOD BRAIN BARRIER
SFRH/BD/65375/2009
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2012/04 Three month internship in the laboratory of Professor Ilpo Vattulainen, Tampere University of Technology, Finland.
SFRH/BD/65375/2009
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
2006 - 2006/12 Erasmus Project – Study of Vesicles and lamellar phases in nonionic surfactants, developed at the University of Calabria, Italy.
unreferenced
Other
Universidade de Coimbra, Portugal
Universidade de Coimbra
Concluded

Contract

Designation Funders
2021 - Current Contratação de Recursos Humanos Altamente Qualificados, com objetivo temático de promover a sustentabilidade e a qualidade do emprego e apoiar a mobilidade laboral
CENTRO-04-3559-FSE-000162
Researcher
Instituto Politécnico da Guarda Unidade de Investigação para o Desenvolvimento do Interior, Portugal
Ongoing
2018 - 2021/07/01 BasUC – Bases ultra concentradas para a produção de produtos de limpeza: controlo sobre fases concentradas de polímeros e tensioativos
POCI-01-0247-FEDER-033368
Post-doc Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
Ongoing
2018 - 2021/07/01 EcoX, Reciclagem de gorduras alimentares através da Química Verde
CENTRO-01-0247-FEDER-033838
Other
Ongoing
2017 - 2018/06/18 Ao encontro das regras para a permeação passiva através da barreira hemato-encefálica
Post-doc Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2017/06 CENTRO DE QUÍMICA – COIMBRA
UID/QUI/00313/2013
Post-doc Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2015 - 2016/10 CENTER OF CHEMISTRY AND BIOCHEMISTRY
UID/MULTI/00612/2013
Post-doc Fellow
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2015/03/31 Finding the naturally evolved design principles of prevalent metabolic circuits
Research Fellow
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2010/04/30 Modelação Quantitativa da Difusão Passiva Trans-citótica de Moléculas Anfifílicas através da Barreira Hemato-Encefálica
Research Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2022 - Current RepDrugCancer - Repurposing drugs to tackle cancer diseases
2021.09741.CPCA
Principal investigator
Instituto Politécnico da Guarda, Portugal
Ongoing
2022 - Current MDFluoMemPro - Molecular dynamics characterization of novel fluorescent membrane probes
CPCA/A1/407703/2021
Researcher
Universidade de Coimbra, Portugal
Ongoing
2019 - Current UCOR - Desenho e caracterização de novas proteínas para a reciclagem eficiente de óleos alimentares usados e produção de produtos verdes
Project LCA-Navigator
Principal investigator
Ongoing
2020 - 2021/05/31 UCORecyclingGP: Design and characterization of novel proteins for efficient recycling of used cocking oils and production of green products
Project DECI-16-UCORecycingGP
Principal investigator
Concluded
2018 - 2019/09/23 Characterization of the interaction and permeation of drug-like molecules through membrane models including P-glycoprotein
unreferenced
Supervisor
Universidade de Coimbra, Portugal
Concluded
2017 - 2018/04/30 High-throughput strategy to calculate rate constants for drug/membrane systems - Project DECI-14-HTRate
Principal investigator
Universidade de Coimbra Centro de Química de Coimbra, Portugal
Concluded
2014 - 2015 Characterization of the frequency factor for the conversion from the transition state into the reaction products in lipid bilayers
Project LCA-Milipeia
Technical development
Universidade de Coimbra, Portugal
Concluded
2014 - 2015 Study of lipid bilayer composed of lipids with the inverted polar group by molecular simulation
Project LCA-Milipeia
Technical development
Universidade de Coimbra, Portugal
Concluded
2014 - 2015 Study of the location and behavior of bile acids in POPC bilayers by molecular dynamics simulations
Project LCA-Milipeia
Technical development
Universidade de Coimbra, Portugal
Concluded
2013 - 2014/04 Interaction of a homologous series of fluorescent probes with different lipid bilayers - Project DECI-10-fplb
Researcher
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2013 - 2014 Translocation and desorption reaction frequency of amphiphiles in POPC bilayers
Project LCA-Milipeia
Technical development
Universidade de Coimbra, Portugal
Concluded
2013 - 2014 Interaction of fluorescent lipid probes NBD-diCnPE with different lipid bilayers
Project LCA-Milipeia
Technical development
Universidade de Coimbra, Portugal
Concluded
2013 - 2014 Potential of Mean Force calculation with different umbrella force constants
Project LCA-Milipeia
Technical development
Universidade de Coimbra, Portugal
Concluded
2012 - 2013 Interaction of a homologous series of fluorescent probes with different lipid bilayers
Project LCA-Milipeia
Technical development
Universidade de Coimbra, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Filipe, Hugo A. L.; Cardoso, Renato M. S.; Loura, Luís M. S.; Moreno, Maria João. "Interaction of Amphiphilic Molecules with Lipid Bilayers: Kinetics of Insertion, Desorption and Translocation". In Membrane Organization and Dynamics, 49-89. Springer International Publishing, 2017.
    10.1007/978-3-319-66601-3_4
Conference abstract
  1. Hugo A. L. Filipe. "Interaction of near infrared (NIR)-light responsive probes with lipid membranes: a molecular dynamics study". Paper presented in 8th International Iberian Biophysics Congress (IIBC2022), Bilbau, 2022.
    Published
  2. Hugo A. L. Filipe. "Interaction of contrast agents with biomembranes". Paper presented in 8th International Iberian Biophysics Congress (IIBC2022), Bilbau, 2022.
    Published
  3. Hugo A. L. Filipe. "The interaction of lipases with different oil/water interfaces: using biomolecular simulations to characterize real life applications; Hugo A. L. Filipe, Maëva C. F. Almeida, Rafaela R. Teixeira, Margarida I. M. Esteves, César A. Henriques and Filipe E. Antunes, 7th International Iberian Biophysics Congress (IIBC2020), Coimbra (Online), Portugal, June 2021, Book of Abstracts, p. 150.". Paper presented in 7th International Iberian Biophysics Congress (IIBC2020), 2021.
  4. Hugo A. L. Filipe. "Interaction of the antibiotic Rifampicin with lipid membranes: molecular dynamics simulations, Rui MS Santos, Alexandre C Oliveira, Hugo AL Filipe, Maria João Moreno, Luís MS Loura, 7th International Iberian Biophysics Congress (IIBC2020), Coimbra (Online), Portugal, June 2021, Book of Abstracts, p. 158.". Paper presented in 7th International Iberian Biophysics Congress (IIBC2020), 2021.
  5. Hugo A. L. Filipe. "Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers, Alexandre C. Oliveira, Hugo A. L. Filipe, Armindo Salvador, Carlos F. G. C. Geraldes, Maria João Moreno, Luís M. S. Loura, 7th International Iberian Biophysics Congress (IIBC2020), Coimbra (Online), Portugal, June 2021, Book of Abstracts, p. 65.". Paper presented in 7th International Iberian Biophysics Congress (IIBC2020), 2021.
  6. Hugo A. L. Filipe. "Quantitative assessment of methods used to obtain rate constants from molecular dynamics simulations - translocation of cholesterol across a lipid bilayer. Hugo A. L. Filipe, Matti Javanainen, Armindo Salvador, Adelino Galvão, Ilpo Vattulainen, Luís M. S. Loura, and Maria João Moreno, 1st Biophysics Party, Oeiras, Portugal, July 2018, Book of Abstracts, p. 42.". 2018.
    Published
  7. Hugo A. L. Filipe. "Quantitative assessment of methods often used to obtain rate constants from biomolecular simulations - translocation of cholesterol across a lipid bilayer". Paper presented in 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics, Castellón, 2018.
    Published
  8. Filipe, Hugo. "Effect of protonation state on the interaction of Hoechst 33342 with lipid membranes - An experimental and computational study". 2017.
    10.3390/mol2net-03-05086
  9. Hugo A. L. Filipe. "Laurdan And NBD-Lipids In Membranes: What Are They Actually Probing? Mariana Amaro, Piotr Jurkiewicz, Hugo A. L. Filipe, J. P. Prates Ramalho, Luís M. S. Loura, Martin Hof, 15th Conference on Methods and Applications in Fluorescence, Bruges, Belgium, September 2017, Book of Abstracts, p. 76.". 2017.
    Published
  10. Hugo A. L. Filipe. "Interaction of bile salts with lipid bilayers: a multiscale molecular dynamics study. M. C. Neves, R. L. Reis, H. A. L. Filipe, J. P. P. Ramalho, M. J. Moreno, L. M. S. Loura, 19th IUPAB congress and 11th EBSA congress, Edinburgh, UK, July 2017, Eur Biophys J (2017) 46(Suppl 1): S125. https://doi.org/10.1007/s00249-017-1222-x.". 2017.
    Published
  11. Hugo A. L. Filipe. "The RED-EDGE Excitation Shift of NBD-Labeled Lipids. M. Amaro, H. A. L. Filipe, J. P. Prates Ramalho, M. Hof, L. M. S. Loura, XII Encontro Nacional de Química-Física, I Simpósio de Química Computacional, Évora, Portugal, June 2016, Book of Abstracts, p. 119.". 2016.
    Published
  12. Hugo A. L. Filipe. "Homeostasis of Free Cholesterol in the Blood – A Preliminary Evaluation and Modeling of its Passive Transport. Estronca LMBB, Filipe HAL, Salvador A, Vaz WLC and Moreno MJ, XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, December 2014.". 2014.
    Published
  13. Hugo A. L. Filipe. "Beyond Overton’s rule - Quantitative Modeling of Passive Permeation Through Tight Cell Monolayers. Filipe HAL, Salvador A, Silvestre JM, Vaz WLC and Moreno MJ, XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, December 2014.". 2014.
    Published
  14. Hugo A. L. Filipe. "Beyond Overton’s Rule - Quantitative Modeling of Passive Permeation through Tight Cell Monolayers. Hugo Filipe, Armindo Salvador, José Silvestre, Winchil Vaz, Maria João Moreno, 20th EuroQSAR - Understanding Chemical-Biological Interactions, St. Petersburg, Russia, 2014, Abstract Book EuroQSAR, P093.". 2014.
    Published
  15. Hugo A. L. Filipe. "Issues in free energy simulations of long amphiphiles interacting with lipid membranes: Convergence and membrane deformation. Filipe, Hugo A. L.; Moreno, Maria J.; Róg, Tomasz; Vattulainen, Ilpo; Loura, Luís M. S. 20th International Symposium on Surfactants in Solution, Coimbra, Portugal, 2014, Book of Abstracts, p. 397.". 2014.
    Published
  16. Hugo A. L. Filipe. "Following amphiphilic molecules on their way through lipid membranes. Hugo A. L. Filipe, M.J. Moreno, L.M.S. Loura, Conference on Scientific Computing, Paphos, Cyprus, 2013, Conference Handbook. http://www.cyi.ac.cy/cscTalks/.". 2013.
    Published
  17. Hugo A. L. Filipe. "Behaviour of NBD-headgroup labelled phosphatidylethanolamines in POPC bilayers: a molecular dynamics study. Lennon S. Santos; Filipe, Hugo A. L.; J. P. Prates Ramalho; Moreno, Maria J.; Loura, Luis M. S., 9th European Biophysics Congress, EBSA2013, Lisboa, Portugal, 2013, Abstracts, European Biophysics Journal, Springer, 2013, v. 42, p. 1-236.". 2013.
    Published
  18. Hugo A. L. Filipe. "Location and fluorescent behavior of NBD-labeled fatty amines in POPC:Chol and SpM:Chol bilayers. Filipe, Hugo A. L.; Tiago Palmeira; Renato Cardoso; Loura, Luis M. S.; Moreno, Maria J., 9th European Biophysics Congress, EBSA2013, Lisboa, Portugal, 2013, Abstracts, European Biophysics Journal, Springer, 2013, v. 42, p. 1-236.". 2013.
    Published
  19. Hugo L. Filipe; Winchil L.C. Vaz. "New Method for the Measurement of Binding Constants for Amphiphiles with a Very Small Solubility in Aqueous Media". 2010.
    http://dx.doi.org/10.1016/j.bpj.2009.12.2607
  20. Filipe, Hugo. "Characterization of a Homologous Series of Fluorescent Fatty Amines. Photophysics, Aqueous Solubility and Binding to Albumin and to POPC Bilayers". 2010.
    10.1016/j.bpj.2009.12.2606
  21. Filipe, Hugo. "Quantitative Modeling of Passive Permeation through the Blood Brain Barrier". 2009.
    10.1016/j.bpj.2008.12.653
  22. Hugo A. L. Filipe. "Quantitative Modeling of Passive Permeation through the Blood Brain Barrier. Hugo Filipe, Maria João Moreno, Winchil L.C. Vaz, Armindo Salvador, 1st Portuguese-Spanish-British Joint Biophysics Congress, Lisboa, Portugal, July 2008.". 2008.
    Published
Conference poster
  1. Hugo A. L. Filipe. "Interaction of contrast agents with biomembranes". Paper presented in 8th International Iberian Biophysics Congress (IIBC2022), 2022.
  2. Hugo A. L. Filipe. "Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers". Paper presented in Biophysics Festival, Aveiro, Portugal, 2022.
  3. Hugo A. L. Filipe. "Interaction of Rifampicin with lipidic membranes – experimental characterization and Molecular Dynamics simulations, Rui MS Santos, Alexandre C Oliveira, Hugo AL Filipe, Maria João Moreno, Luís MS Loura, Coimbra Chemistry Centre Day 2021, Coimbra, December 2021". Paper presented in Coimbra Chemistry Centre Day 2021, 2021.
  4. Hugo A. L. Filipe. "Interaction of the antibiotic Rifampicin with lipid membranes: molecular dynamics simulations". Paper presented in 7th International Iberian Biophysics Congress (IIBC2020), 2021.
  5. Hugo A. L. Filipe. "The interaction of lipases with different oil/water interfaces: using biomolecular simulations to characterize real life applications". Paper presented in 7th International Iberian Biophysics Congress (IIBC2020), 2021.
  6. Hugo A. L. Filipe. "Dancing with oils - The interaction of lipases with different oil/water interfaces". Paper presented in 14º Encontro de Química Física, 2021.
  7. Hugo A. L. Filipe. "Interaction of a Homologous Series of Amphiphiles with P-Glycoprotein Containing Membranes". Paper presented in Annual Meeting Biophysical Society, 2021.
  8. Hugo A. L. Filipe. "The Role of Waste Frying Oils as Bioactive Agents". Paper presented in 10th International Colloids Conference 2020, 2020.
  9. Hugo A. L. Filipe. "Valorisation of Used Cooking Oils – A Green Chemistry and Circular Economy Approach". Paper presented in 10th International Colloids Conference 2020, 2020.
  10. Hugo A. L. Filipe. ""Quantitative assessment of methods used to obtain rate constants from molecular dynamics simulations - translocation of cholesterol across a lipid bilayer", Hugo A. L. Filipe, Matti Javanainen, Armindo Salvador, Adelino Galvão, Ilpo Vattulainen, Luís M. S. Loura, and Maria João Moreno, Biophysics Party, Lisboa, Portugal, July 2018.". 2018.
  11. Hugo A. L. Filipe. "“Permeation of Amphiphilic Drug-like Molecules through Symmetric and Asymmetric Lipid Bilayers – A Molecular Dynamics Simulation Study”, Hugo A. L. Filipe, Luís M. S. Loura and Maria João Moreno, 665. WE-Heraeus-Seminar on Physical Approaches to Membrane Asymmetry, Physikzentrum Bad Honnef, Germany, March 2018.". 2018.
  12. Filipe, Hugo; Moreno, Maria João; Santos, Patrícia; Ramalho, João; Loura, Luís. "Effect of protonation state on the interaction of Hoechst 33342 with lipid membranes - An experimental and computational study.". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural, EJIBCE 2017, 2017.
    10.3390/mol2net-03-05086
  13. Hugo A. L. Filipe. "“Interaction of bile salts with lipid bilayers: a multiscale molecular dynamics study”, M. C. Neves, R. L. Reis, H. A. L. Filipe, J. P. P. Ramalho, M. J. Moreno, L. M. S. Loura, 19th IUPAB congress and 11th EBSA congress, Edinburgh, UK, July 2017.". 2017.
  14. Hugo A. L. Filipe. "“Assessing lipophilicity of plant polyphenolic compounds: different experimental approaches”, António G. Flor, Carla S. Sousa, Hugo A. L. Filipe, Joaquim T. Marquês, Ana S. Viana, Miguel Machuqueiro, Maria S.C.S. Santos, Rodrigo F. M. de Almeida, The Chemistry and Biochemistry Centre Day, Lisbon, May 2017 (Award for best poster).". 2017.
  15. Hugo A. L. Filipe. "“Plant phenolic acids interact weakly with membrane models and human cells, despite their effect on cytoskeleton organization”, Carla Sousa, António G. Flor, Hugo A. L. Filipe, Catarina Peneda, Helena Soares, H. Susana Marinho, Rodrigo F. M. de Almeida, 4th Annual Conference of redeSAÚDE, May 2017.". 2017.
  16. Hugo A. L. Filipe. "“Natural caffeic acid ester derivatives affect lipid bilayers surface and human cells cytoskeleton organization”, Carla Sousa, António G. Flor, Hugo A. L. Filipe, Catarina Peneda, Helena Soares, H. Susana Marinho, Rodrigo F. M. de Almeida, The Chemistry and Biochemistry Centre Day, Lisbon, May 2017.". 2017.
  17. Hugo A. L. Filipe. "“Healthy Life: Interaction of polyphenols with lipid bilayers and their effects in human cells”, Hugo A. L. Filipe, Catarina Peneda, Joaquim T. Marquês, Miguel Machuqueiro, João C. Ramos, Maria da Soledade Santos, H. Susana Marinho, Ana S. Viana, Helena Soares, Rodrigo F. M. de Almeida, The Chemistry and Biochemistry Centre Day, Lisbon, June 2016.". 2016.
  18. Hugo A. L. Filipe. ""The RED-EDGE Excitation Shift of NBD-Labeled Lipids", M. Amaro, H. A. L. Filipe, J. P. Prates Ramalho, M. Hof, L. M. S. Loura, XII Encontro Nacional de Química-Física, I Simpósio de Química Computacional, Évora, Portugal, June 2016.". 2016.
  19. Hugo A. L. Filipe. ""Beyond Overton’s rule - Quantitative Modeling of Passive Permeation Through Tight Cell Monolayers", Filipe HAL, Salvador A, Silvestre JM, Vaz WLC and Moreno MJ, XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, December 2014.". 2014.
  20. Hugo A. L. Filipe. ""Homeostasis of Free Cholesterol in the Blood – A Preliminary Evaluation and Modeling of its Passive Transport", Estronca LMBB, Filipe HAL, Salvador A, Vaz WLC and Moreno MJ, XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, December 2014.". 2014.
  21. Hugo A. L. Filipe. "“Beyond Overton’s Rule - Quantitative Modeling of Passive Permeation through Tight Cell Monolayers”, Hugo Filipe, Armindo Salvador, José Silvestre, Winchil Vaz, Maria João Moreno, 20th EuroQSAR - Understanding Chemical-Biological Interactions, St. Petersburg, Russia, August 31 - September 4, 2014.". 2014.
  22. Hugo A. L. Filipe. "“Issues in free energy simulations of long amphiphiles interacting with lipid membranes: Convergence and membrane deformation”, Hugo A. L. Filipe, Maria João Moreno, Tomasz Róg, Ilpo Vattulainen, Luís M. S. Loura, 20th International Symposium on Surfactants in Solution, SIS 2014, Coimbra, Portugal, June 2014.". 2014.
  23. Hugo A. L. Filipe. "“Behaviour of NBD-headgroup labelled phosphatidylethanolamines in POPC bilayers: a molecular dynamics study”, L. S. Santos; H. A. L. Filipe; J. P. Prates Ramalho; M. J. Moreno; L. M. S. Loura, 9th European Biophysics Congress, EBSA2013, Lisboa, Portugal, July 2013.". 2013.
  24. Hugo A. L. Filipe. "“Location and fluorescent behavior of NBD-labeled fatty amines in POPC:Chol and SpM:Chol bilayers”, Hugo Filipe, Tiago Palmeira, Renato Cardoso, Luis Loura and Maria João Moreno, 9th European Biophysics Congress, EBSA2013, Lisboa, Portugal, July 2013.". 2013.
  25. Hugo A. L. Filipe. "“New Method for the Measurement of Binding Constants for Amphiphiles with a Very Small Solubility in Aqueous Media”, Hugo L. Filipe, Winchil L.C. Vaz, Maria João Moreno, 54th Annual Meeting of Biophysical Society, San Francisco, California, USA, February 2010.". 2010.
  26. Hugo A. L. Filipe. ""Characterization of a Homologous Series of Fluorescent Fatty Amines: Photophysics, Aqueous Solubility and Binding to Albumin and to POPC Bilayers", Cardoso R, Filipe H, Vaz WLC, Moreno MJ, 54th Annual Meeting of Biophysical Society, San Francisco, California, USA, February 2010.". 2010.
  27. Hugo A. L. Filipe. ""Quantitative Modeling of Passive Permeation through the Blood Brain Barrier", Hugo Filipe, Armindo Salvador, Winchil Vaz, Maria João Moreno, 53rd Annual Meeting of Biophysical Society, Boston, Massachusetts, USA, February 28 - March 4, 2009.". 2009.
  28. Hugo A. L. Filipe. ""Quantitative Modeling of Passive Permeation through the Blood Brain Barrier", Hugo Filipe, Maria João Moreno, Winchil L.C. Vaz, Armindo Salvador, 1st Portuguese-Spanish-British Joint Biophysics Congress, Lisboa, Portugal, July 2008.". 2008.
  29. Hugo A. L. Filipe. ""Mixtures of oppositely charged polyelectrolytes. Role of pH and salt", Hugo Louro, Filipe E. Antunes, Bjorn Lindman, Maria G. Miguel, II Reunião Ibérica de Colóides e Interfaces, Coimbra, Portugal, July 2007.". 2007.
Journal article
  1. Oliveira, Alexandre C.; Filipe, Hugo A. L.; Ramalho, João P. Prates; Salvador, Armindo; Geraldes, Carlos F. G. C.; Moreno, Maria João; Loura, Luís M. S.. "Modeling Gd3+ Complexes for Molecular Dynamics Simulations: Toward a Rational Optimization of MRI Contrast Agents". Inorganic Chemistry 61 30 (2022): 11837-11858. http://dx.doi.org/10.1021/acs.inorgchem.2c01597.
    10.1021/acs.inorgchem.2c01597
  2. Filipe, Hugo A. L.; Loura, Luís M. S.. "Molecular Dynamics Simulations: Advances and Applications". Molecules 27 7 (2022): 2105. http://dx.doi.org/10.3390/molecules27072105.
    10.3390/molecules27072105
  3. Magalhães, Nisa; Simões, Guilherme M.; Ramos, Cristiana; Samelo, Jaime; Oliveira, Alexandre C.; Filipe, Hugo A. L.; Ramalho, João P. Prates; Moreno, Maria João; Loura, Luís M. S.. "Interactions between Rhodamine Dyes and Model Membrane Systems—Insights from Molecular Dynamics Simulations". Molecules 27 4 (2022): 1420. http://dx.doi.org/10.3390/molecules27041420.
    10.3390/molecules27041420
  4. Filipe, Hugo A.L.; Fiuza, Sónia M.; Henriques, César A.; Antunes, Filipe E.. "Antiviral and antibacterial activity of hand sanitizer and surface disinfectant formulations". International Journal of Pharmaceutics 609 (2021): 121139. http://dx.doi.org/10.1016/j.ijpharm.2021.121139.
    10.1016/j.ijpharm.2021.121139
  5. Cunha, Susana V.; Filipe, Hugo L.; Ramos, Cristiana V.; Martins, Patricia A.; Abel, Biebele; Ambudkar, Suresh V.; Loura, Luis M.; Joao Moreno, Maria. "Interaction of a Homologous Series of Amphiphiles with P-Glycoprotein Containing Membranes". Biophysical Journal 120 3 (2021): 43a. http://dx.doi.org/10.1016/j.bpj.2020.11.508.
    10.1016/j.bpj.2020.11.508
  6. Hugo A. L. Filipe; Maëva C. F. Almeida; Rafaela R. Teixeira; Margarida I. M. Esteves; César A. Henriques; Filipe E. Antunes. "Dancing with oils – the interaction of lipases with different oil/water interfaces". Soft Matter (2021): https://doi.org/10.1039/D1SM00590A.
    10.1039/D1SM00590A
  7. Hugo A. L. Filipe; Maria João Moreno; Luís M. S. Loura. "The Secret Lives of Fluorescent Membrane Probes as Revealed by Molecular Dynamics Simulations". Molecules (2020): https://doi.org/10.3390/molecules25153424.
    10.3390/molecules25153424
  8. Hugo A. L. Filipe; Margarida I. M. Esteves; César A. Henriques; Filipe E. Antunes. "Effect of Protein Flexibility from Coarse-Grained Elastic Network Parameterizations on the Calculation of Free Energy Profiles of Ligand Binding". Journal of Chemical Theory and Computation (2020): https://doi.org/10.1021/acs.jctc.0c00418.
    10.1021/acs.jctc.0c00418
  9. Neves, Maria C.; Filipe, Hugo A. L.; Reis, Rita Leones; Prates Ramalho, João P.; Coreta-Gomes, Filipe; Moreno, Maria J.; Loura, Luis M. S.. "Interaction of Bile Salts With Lipid Bilayers: An Atomistic Molecular Dynamics Study". Frontiers in Physiology 10 (2019): http://dx.doi.org/10.3389/fphys.2019.00393.
    10.3389/fphys.2019.00393
  10. Hugo A. L. Filipe; Šárka Pokorná; Martin Hof; Mariana Amaro; Luís M. S. Loura. "Orientation of nitro-group governs the fluorescence lifetime of nitrobenzoxadiazole (NBD)-labeled lipids in lipid bilayers". Physical Chemistry Chemical Physics (2019): https://doi.org/10.1039/C8CP06064A.
    10.1039/C8CP06064A
  11. António de Granada-Flor; Carla Sousa; Hugo A. L. Filipe; M. Soledade C. S. Santos; Rodrigo F. M. de Almeida. "Quercetin dual interaction at the membrane level". Chemical Communications (2019): https://doi.org/10.1039/C8CC09656B.
    10.1039/C8CC09656B
  12. Hugo A. L. Filipe; Matti Javanainen; Armindo Salvador; Adelino M. Galvão; Ilpo Vattulainen; Luís M. S. Loura; Maria João Moreno. "Quantitative Assessment of Methods Used To Obtain Rate Constants from Molecular Dynamics Simulations—Translocation of Cholesterol across Lipid Bilayers". Journal of Chemical Theory and Computation 14 7 (2018): 3840-3848. https://doi.org/10.1021/acs.jctc.8b00150.
    10.1021/acs.jctc.8b00150
  13. Filipe, H.A.L.; Sousa, C.; Marquês, J.T.; Vila-Viçosa, D.; de Granada-Flor, A.; Viana, A.S.; Santos, M.S.C.S.; Machuqueiro, M.; de Almeida, R.F.M.. "Differential targeting of membrane lipid domains by caffeic acid and its ester derivatives". Free Radical Biology and Medicine 115 (2018): 232-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037991015&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2017.12.002
  14. Amaro, M.; Filipe, H.A.L.; Prates Ramalho, J.P.; Hof, M.; Loura, L.M.S.. "Fluorescence of nitrobenzoxadiazole (NBD)-labeled lipids in model membranes is connected not to lipid mobility but to probe location". Physical Chemistry Chemical Physics 18 10 (2016): 7042-7054. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960153667&partnerID=MN8TOARS.
    10.1039/c5cp05238f
  15. Filipe, H.A.L.; Bowman, D.; Palmeira, T.; Cardoso, R.M.S.; Loura, L.M.S.; Moreno, M.J.. "Interaction of NBD-labelled fatty amines with liquid-ordered membranes: A combined molecular dynamics simulation and fluorescence spectroscopy study". Physical Chemistry Chemical Physics 17 41 (2015): 27534-27547. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944345741&partnerID=MN8TOARS.
    10.1039/c5cp04191k
  16. Filipe, H.A.L.; Santos, L.S.; Prates Ramalho, J.P.; Moreno, M.J.; Loura, L.M.S.. "Behaviour of NBD-head group labelled phosphatidylethanolamines in POPC bilayers: a molecular dynamics study". Physical Chemistry Chemical Physics 17 31 (2015): 20066-20079. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938231872&partnerID=MN8TOARS.
    10.1039/c5cp01596k
  17. Filipe, H.A.L.; Salvador, A.; Silvestre, J.M.; Vaz, W.L.C.; Moreno, M.J.. "Beyond overton's rule: Quantitative modeling of passive permeation through tight cell monolayers". Molecular Pharmaceutics 11 10 (2014): 3696-3706. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907978479&partnerID=MN8TOARS.
    10.1021/mp500437e
  18. Estronca, L.M.B.B.; Filipe, H.A.L.; Salvador, A.; Moreno, M.J.; Vaz, W.L.C.. "Homeostasis of free cholesterol in the blood: A preliminary evaluation and modeling of its passive transport". Journal of Lipid Research 55 6 (2014): 1033-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660412&partnerID=MN8TOARS.
    10.1194/jlr.M043067
  19. Filipe, H.A.L.; Moreno, M.J.; Róg, T.; Vattulainen, I.; Loura, L.M.S.. "How to tackle the issues in free energy simulations of long amphiphiles interacting with lipid membranes: Convergence and local membrane deformations". Journal of Physical Chemistry B 118 13 (2014): 3572-3581. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898068334&partnerID=MN8TOARS.
    10.1021/jp501622d
  20. Filipe, H.A.L.; Coreta-Gomes, F.M.; Velazquez-Campoy, A.; Almeida, A.R.; Peixoto, A.F.; Pereira, M.M.; Vaz, W.L.C.; Moreno, M.J.. "Synthesis and characterization of a lipidic alpha amino acid: Solubility and interaction with serum albumin and lipid bilayers". Journal of Physical Chemistry B 117 13 (2013): 3439-3448. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875796066&partnerID=MN8TOARS.
    10.1021/jp307874v
  21. Filipe, H.A.L.; Moreno, M.J.; Loura, L.M.S.. "Interaction of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled fatty amines with 1-palmitoyl, 2-oleoyl-sn-glycero-3-phosphocholine bilayers: A molecular dynamics study". Journal of Physical Chemistry B 115 33 (2011): 10109-10119. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860408645&partnerID=MN8TOARS.
    10.1021/jp203532c
  22. Cardoso, R.M.S.; Filipe, H.A.L.; Gomes, F.; Moreira, N.D.; Vaz, W.L.C.; Moreno, M.J.. "Chain length effect on the binding of amphiphiles to serum albumin and to POPC bilayers". Journal of Physical Chemistry B 114 49 (2010): 16337-16346. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650155862&partnerID=MN8TOARS.
    10.1021/jp105163k
Thesis / Dissertation
  1. Hugo A. L. Filipe. "Following Amphiphilic Molecules on Their Way through Lipid Membranes: Development of a Kinetic Model of Passive Permeation through the Blood-Brain Barrier". PhD, Universidade de Coimbra, 2014. http://hdl.handle.net/10316/27079.
  2. Hugo A. L. Filipe. "Quantitative Modeling of Passive Permeation through the Blood-Brain Barrier". Master, Universidade de Coimbra, 2009. https://drive.google.com/open?id=13mgK0HtvzTjuwOyCzEZ8lPRqbYclNjoR.
  3. Hugo A. L. Filipe. "Mixtures of Hydrophobically Modified Polyelectrolytes and Cyclodextrins, and Vesicles and Lamellar phases in Nonionic Surfactant Systems". Degree, Universidade de Coimbra, 2006. https://drive.google.com/open?id=1KR93chcvMEPn6TWyq7SJMGnGzcDgr8zv.
Website
  1. Hugo A. L. Filipe. Editor of the website of the Biological Chemistry group of Coimbra Chemistry Center.. 2011. http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/06 Interaction of near infrared (NIR)-light responsive probes with lipid membranes: a molecular dynamics study 8th International Iberian Biophysics Congress (IIBC2022)
(Bilbau, Spain)
2021/09/10 Multi-Modelling of Biological and Biomolecular Systems As 4 estações da ciência do IPG
Instituto Politécnico da Guarda (Guarda, Portugal)
2021/06 Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers 7th International Iberian Biophysics Congress (IIBC2020)
(Portugal)
2019/10/13 Effect of protein (in)flexibility on the calculation of ligand binding free energy profiles using coarse-grained force fields Workshop on Biological Chemistry (WBC) 2019 - Lipids & Proteins - Interactions for Life
Universidade de Coimbra (Nespereira, Portugal)
2018/06 Quantitative assessment of methods often used to obtain rate constants from biomolecular simulations - translocation of cholesterol across a lipid bilayer 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics
(Castellón, Spain)
2018/03 Permeation of Amphiphilic Drug-like Molecules through Symmetric and Asymmetric Lipid Bilayers – A Molecular Dynamics Simulation Study WE-Heraeus-Seminar on Physical Approaches to Membrane Asymmetry
(Bad Honnef, Germany)
2017/09 Laurdan And NBD-Lipids In Membranes: What Are They Actually Probing 15th Conference on Methods and Applications in Fluorescence
(Bruges, Belgium)
2017/03 Passive permeation of small molecules through biomembranes: mechanism and implications for drug delivery NIH, Bethesda, USA, March 2017
NIH (Bethesda, United States)
2017/02 Interaction of Plant Polyphenols with Lipid Bilayers: a Fluorescence Spectroscopy Characterization Chem&BioChem Postgraduate Students Meeting 2017
(Lisbon, Portugal)
2016/07 Importance of passive processes in cholesterol homeostasis - absorption at the intestine and distribution in the blood
Instituto Superior Técnico, Universidade de Lisboa (Lisbon, Portugal)
2016/06 Healthy Life: Interaction of polyphenols with lipid bilayers and their effects in human cells The Chemistry and Biochemistry Centre Day
University of Lisbon (Lisbon, Portugal)
2016/04 Importance of passive processes in cholesterol homeostasis - absorption at the intestine and distribution in the blood 5th PYChem/1st EYChem
(Braga, Portugal)
2015/12 Following Amphiphilic Molecules on their Way through Lipid Membranes: towards to a Healthy Life CQB Autumn Seminars
University of Lisbon (Lisboa, Portugal)
2015/06 Homeostasis of Free Cholesterol in the Blood – Kinetic Parameters and Modeling of its Passive Transport XXIV National Meeting of the Portuguese Chemical Society
(Coimbra, Portugal)
2014/12 Beyond Overton’s rule: Quantitative Modeling of Passive Permeation Through Tight Cell Monolayers XII CNC Annual Meeting
University of Coimbra (Coimbra, Portugal)
2014/11 Bioavailability of Amphiphilic Molecules: Exploring the Rules of Passive Pathways Computational Biology @ UC Workshop
University of Coimbra (Coimbra, Portugal)
2014/09 Bioavailability of amphiphilic molecules: Exploring the rules of passive pathways The Chemistry Center Day
University of Coimbra (Coimbra, Portugal)
2014/09 Following amphiphilic molecules on their way through lipid membranes The Chemistry Centre Day
(Coimbra, Portugal)
2013/12 Following amphiphilic molecules on their way through lipid membranes Conference on Scientific Computing 2013 (CSC 2013)
(Paphos, Cyprus)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019 - 2020 Reaproveitamento de Gordura Animal - Transformação em Detergentes (Reuse of Animal Fat - Transformation into Detergents)
Co-supervisor
Química (Master)
Universidade de Coimbra, Portugal
2019 - 2020 Reaproveitamento de Óleo Alimentar Usado (Reuse of Used Cooking Oil)
Co-supervisor
Química (Master)
Universidade de Coimbra, Portugal
2018/09/24 - 2019/09/23 Characterization of the interaction and permeation of drug-like molecules through membrane models including P-glycoprotein
Supervisor
MSc program in Molecular and Cell Biology (Master)
Universidade de Coimbra, Portugal
2018/01/02 - 2018/06/30 Estudo da interacção da Rodamina 123 com bicamadas lipídicas de POPC
Co-supervisor
Medicinal Chemistry (Degree)
Universidade de Coimbra, Portugal
2018/01/02 - 2018/06/30 Estudo da interacção de drogas com bicamadas lipídicas de POPC
Co-supervisor
Medicinal Chemistry
Universidade de Coimbra, Portugal
2017/09/16 - 2017/11/27 Estudo da interacção da Hoechst 33342 com bicamadas lipídicas de POPC
Co-supervisor
MSc program in Medicinal Chemistry - Laboratorial rotation (Master)
Universidade de Coimbra, Portugal
2017/01/02 - 2017/06/30 Analysis of structure activity relationships in the permeation of lipid membranes containing P-glycoprotein
Co-supervisor
MSc. internship at the University of Coimbra, under the VIT University Semester Abroad Programme (Master)
Universidade de Coimbra, Portugal
2016/09/01 - 2017/06/30 Estudo do Comportamento e Velocidade de Permeação de Ácidos Biliares em Membranas de POPC
Co-supervisor
Chemistry (Master)
Universidade de Coimbra, Portugal
2017/01/27 - 2017/04/26 Characterization of the association of small molecules with P-glycoprotein reconstituted in lipid bilayers using computational approaches
Co-supervisor
PhD program in Medicinal Chemistry - Laboratorial rotation. (PhD)
Universidade de Coimbra, Portugal
2016/01/02 - 2016/06/30 Estudo do comportamento e localização de Ácidos biliares em bicamadas de POPC através de Dinâmica Molecular
Co-supervisor
Chemistry (Degree)
Universidade de Coimbra, Portugal
2016/01/02 - 2016/06/06 Study of the interaction of phytochemicals with lipid bilayers
Co-supervisor
Faculdade de Pierre et Marie Curie – Stages d'Eté Lisbonne 2016 pour Etudiants de Licence en Chimie (L2/L3) (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/01/02 - 2013/06/30 Estudo do Comportamento de Moléculas anfifílicas fluorescentes em membranas lipídicas por dinâmica molecular
Co-supervisor
Chemistry (Degree)
Universidade de Coimbra, Portugal
2013/01/02 - 2013/06/30 Estudo da localização e comportamento de sais biliares em bicamadas de POPC por dinâmica molecular
Co-supervisor
Medicinal Chemistry (Degree)
Universidade de Coimbra, Portugal
2009/01/02 - 2009/06/30 Synthesis and Characterization of a Lipidic Alpha Amino Acid: Solubility and Interaction with Serum Albumin and Lipid Bilayers
Co-supervisor
Biochemistry (Degree)
Universidade de Coimbra, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021/10/01 - Current "As 4 estações de ciência do IPG" - a set of science seminars. The seminars include two presentations by researchers, professors or students, followed by a brief period of discussion. This event aims to make the IPG community aware of the R&DT activities carried out by its various research groups, thus promoting a more effective collaborative environment, which may lead to the submission of new joint projects and, consequently, increase the visibility and funding of respective groups. (2021/10/01) Instituto Politécnico da Guarda, Portugal
2020/09/02 - 2020/09/15 Summer School in Computational Biology (2020/09/02 - 2020/09/15)
Workshop (Other)
Universidade de Coimbra, Portugal
2020/06/17 - 2020/06/19 7th International Iberian Biophysics Congress - IIBC2020 (https://iibc2020.organideia.pt/) (2020/06/17 - 2020/06/19)
Congress
Universidade de Coimbra, Portugal
2019/09/02 - 2019/09/12 Summer School in Computational Biology (2019/09/02 - 2019/09/12)
Workshop (Other)
Universidade de Coimbra, Portugal
2018/11/16 - 2018/11/18 WBC 2018 - Computational tools to predict drug bioavailability - from molecules to cells (http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E/ResearchEvents/wbc/wbc2018) (2018/11/16 - 2018/11/18)
Workshop (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2018/09/05 - 2018/09/14 Summer School in Computational Biology (2018/09/05 - 2018/09/14)
Workshop (Other)
Universidade de Coimbra, Portugal
2018/07/06 - 2018/07/06 Biophysics Party, 6 July 2018, ITQB Oeiras, an activity promoted by the Young Biophysics group (PYBphy) of Portuguese Biophysics Society (SPBf). (https://pybphy.wixsite.com/1stbiophysicsparty/committee) (2018/07/06 - 2018/07/06)
Meeting (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/05/30 - 2018/05/30 “mini-Symposium: The life of Inorganic Chemistry”, 30 May 2018, Coimbra. (http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E/ResearchEvents/minisymlic) (2018/05/30 - 2018/05/30)
Symposium (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2018/02/16 - 2018/02/17 “mini-Symposium on P-gp”, 16 and 17 February 2018, Coimbra. (http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E/ResearchEvents/minSymPgp) (2018/02/16 - 2018/02/17)
Symposium (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2016 - 2018 Organization of the general meetings of the Biological Chemistry group of Coimbra Chemistry Center, 2016-2018 (http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E/ResearchEvents/wbc) (2016 - 2018)
Workshop (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2010 - 2018 Editor of the website of the Biological Chemistry group of Coimbra Chemistry Center. (http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E) (2010 - 2018)
Other (Other)
Universidade de Coimbra, Portugal
2017/09/04 - 2017/09/14 Summer School in Computational Biology (2017/09/04 - 2017/09/14)
Workshop (Other)
Universidade de Coimbra, Portugal
2017/07/07 - 2017/07/09 WBC 2017 - Understanding Passive Permeation through Biomembranes (http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E/ResearchEvents/wbc/wbc2017) (2017/07/07 - 2017/07/09)
Workshop (Co-organisor)
Universidade de Coimbra, Portugal
2017/02/24 - 2017/02/25 Participation in the Outreach activity “Mostra de Ciência da FCTUC no Alma Shopping”, from 24 to 25 February 2017, promoting the scientific activities developed by the Coimbra Chemistry Center. (2017/02/24 - 2017/02/25)
Exhibition (Other)
Universidade de Coimbra, Portugal
2016 - 2016 Classroom seminar: "Following Amphiphilic Molecules on their Way through Lipid Membranes" for the students of the discipline Structure and Dynamics of Biomembranes, Degree in Biochemistry, 2nd semester, 2015/2016, Chemistry and Biochemistry Department of the University of Lisbon. (2016 - 2016)
Seminar (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/09/02 - 2015/09/11 Summer School in Computational Biology (2015/09/02 - 2015/09/11)
Workshop (Other)
Universidade de Coimbra, Portugal
2009 - 2014 Collaboration in several editions of “Olimpíadas da Química Júnior” of the Portuguese Chemical Society, in the Chemistry Department of the University of Coimbra. (2009 - 2014)
Call (Other)
Universidade de Coimbra, Portugal
2013 - 2013 Classoom Seminar: "Quantitative Modeling of Passive Permeation through Tight Cell Monolayers" for the students of the discipline Biophysical Chemistry, Master in Medicinal Chemistry, 1st semester, 2013/2014, Chemistry Department of the University of Coimbra. (2013 - 2013)
Seminar (Other)
Universidade de Coimbra, Portugal
2013 - 2013 Classroom Seminar: "Quantitative Structure Property Relationships for Passive Permeation through Tight Cell Monolayers" for the students of the discipline Biophysical Chemistry, Master in Medicinal Chemistry, 1st semester, 2013/2014, Chemistry Department of the University of Coimbra. (2013 - 2013)
Seminar (Other)
Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/06 - 2022/06 8th International Iberian Biophysics Congress (IIBC2022) - Oral presentation - “Interaction of near infrared (NIR)-light responsive probes with lipid membranes: a molecular dynamics study”
2021/06 - 2021/06 7th International Iberian Biophysics Congress (IIBC2020) - Poster Presentation - The interaction of lipases with different oil/water interfaces: using biomolecular simulations to characterize real life applications, Hugo A. L. Filipe, Maëva C. F. Almeida, Rafaela R. Teixeira, Margarida I. M. Esteves, César A. Henriques and Filipe E. Antunes
Congress
7th International Iberian Biophysics Congress (IIBC2020)
Universidade de Coimbra, Portugal
2021/03 - 2021/03 14º Encontro de Química Física (14ENQF) - Poster Presentation - Dancing with oils – The interaction of lipases with different oil/water interfaces, Hugo A. L. Filipe, Maëva C. F. Almeida, Rafaela R. Teixeira, Margarida I. M. Esteves, César A. Henriques and Filipe E. Antunes
Congress
14º Encontro de Química Física (14ENQF)
Universidade de Coimbra, Portugal
2019/10/11 - 2019/10/13 WBC 2019 - Lipids & Proteins - Interactions for Life (http://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_E/ResearchEvents/wbc/wbc2019)
Workshop
WBC 2019 - Lipids & Proteins - Interactions for Life
Universidade de Coimbra, Portugal
2018/07 - 2018/07 1st Biophysics Party, Lisboa, Portugal, July 2018 - Poster Presentation - "Quantitative assessment of methods used to obtain rate constants from molecular dynamics simulations - translocation of cholesterol across a lipid bilayer", Hugo A. L. Filipe, Matti Javanainen, Armindo Salvador, Adelino Galvão, Ilpo Vattulainen, Luís M. S. Loura, and Maria João Moreno.
Meeting
Biophysics Party
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/06 - 2018/06 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics, Castellón, Spain, June2018. - Oral presentation - "Quantitative assessment of methods often used to obtain rate constants from biomolecular simulations - translocation of cholesterol across a lipid bilayer", Hugo A. L. Filipe, Matti Javanainen, Armindo Salvador, Adelino Galvão, Ilpo Vattulainen, Luís M. S. Loura, and Maria João Moreno. 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics
2018/03 - 2018/03 665. WE-Heraeus-Seminar on Physical Approaches to Membrane Asymmetry, Physikzentrum Bad Honnef, Germany, March 2018 - Poster Presentation - “Permeation of Amphiphilic Drug-like Molecules through Symmetric and Asymmetric Lipid Bilayers – A Molecular Dynamics Simulation Study”, Hugo A. L. Filipe, Luís M. S. Loura and Maria João Moreno.
Meeting
665. WE-Heraeus-Seminar on Physical Approaches to Membrane Asymmetry
2017/12 - 2017/12 Encontro de Jovens Investigadores de Biologia Computacional Estrutural, EJIBCE 2017, Coimbra, Portugal, December 2017 - Poster Presentation - “Effect of protonation state on the interaction of Hoechst 33342 with lipid membranes - An experimental and computational study”, Santos, P.; Filipe, H.; Ramalho, J.; Loura, L.; Moreno, M.
Meeting
Encontro de Jovens Investigadores de Biologia Computacional Estrutural, EJIBCE 2017
2017/08 - 2017/08 “2017 Martini Workshop”, from 20 to 25 August 2017, University of Groningen, Bernoulliborg, Groningen, The Netherlands (https://drive.google.com/open?id=1E01Wy0kPLRRp64QVurWiP7D0s6_8InN4)
Workshop
2017 Martini Workshop
2016/06/29 - 2016/06/29 Symposium: Understanding the Molecular Brain in Health and Disease, FCUL June 29, 2016
Symposium
Symposium: Understanding the Molecular Brain in Health and Disease
2016/06 - 2016/06 The Chemistry and Biochemistry Centre Day, Lisbon, June 2016 - Oral presentation and Poster presentation - “Healthy Life: Interaction of polyphenols with lipid bilayers and their effects in human cells”, Hugo A. L. Filipe, Catarina Peneda, Joaquim T. Marquês, Miguel Machuqueiro, João C. Ramos, Maria da Soledade Santos, H. Susana Marinho, Ana S. Viana, Helena Soares, Rodrigo F. M. de Almeida
Meeting
The Chemistry and Biochemistry Centre Day
2016/05/20 - 2016/05/22 WBC 2016 - Insights on Targeting Amyloid
Workshop
WBC 2016 - Insights on Targeting Amyloid
Universidade de Coimbra, Portugal
2016/05/05 - 2016/05/05 Conferência Comunica Ciências, Lisbon, FCUL May 5, 2016
Conference
Conferência Comunica Ciências
2016/05/03 - 2016/05/03 Semana da Inovação da ULisboa, 3.ª Conferência Anual da rede SAÚDE, Lisbon, May 3, 2016
Conference
Semana da Inovação da ULisboa, 3.ª Conferência Anual da rede SAÚDE
2016/03/04 - 2016/03/04 Healthy life Festival, FCUL, March 4, 2016, Lisbon Healthy life Festival
2015/11/27 - 2015/11/27 Workshop to launch the nutriageing website, Prof. Amélia Pilar Rauter, 27 November 2015, Lisbon
Workshop
Workshop to launch the nutriageing website
2015/11/25 - 2015/11/25 VI Annual Conference of the Health Cluster Portugal & Market Open innovation in Health, November 25, 2015, Lisbon
Conference
VI Annual Conference of the Health Cluster Portugal & Market Open innovation in Health
2014/12 - 2014/12 XII CNC Annual Meeting, Coimbra, December 2014. - Oral presentation - “Beyond Overton’s rule: Quantitative Modeling of Passive Permeation Through Tight Cell Monolayers”, Hugo A. L. Filipe, Salvador A., Silvestre J.M., Vaz W.L.C. and Moreno M.J. XII CNC Annual Meeting
2014/11 - 2014/11 Computational Biology @ UC Workshop, Coimbra, November 2014. - Oral presentation - “Bioavailability of Amphiphilic Molecules: Exploring the Rules of Passive Pathways”, Hugo Filipe, Armindo Salvador and Maria João Moreno. Computational Biology @ UC Workshop
2014/09 - 2014/09 The Chemistry Centre Day, Coimbra, September 2014. - Oral presentation - “Following amphiphilic molecules on their way through lipid membranes” Hugo Filipe, Maria João Moreno, Luís Loura, The Chemistry Centre Day
2014/06 - 2014/06 20th International Symposium on Surfactants in Solution, SIS 2014, Coimbra, Portugal, June 2014. - Poster Presentation - “Issues in free energy simulations of long amphiphiles interacting with lipid membranes: Convergence and membrane deformation”, Hugo A. L. Filipe, Maria João Moreno, Tomasz Róg, Ilpo Vattulainen, Luís M. S. Loura.
Congress
20th International Symposium on Surfactants in Solution, SIS 2014
2013/12 - 2013/12 Conference on Scientific Computing 2013 (CSC 2013), Paphos, Cyprus, December 2013. - Oral presentation - “Following amphiphilic molecules on their way through lipid membranes”, Hugo A.L. Filipe, M.J. Moreno, L.M.S. Loura. Conference on Scientific Computing 2013 (CSC 2013)
2013/07 - 2013/07 9th European Biophysics Congress, EBSA2013, Lisboa, Portugal, July 2013. - Poster Presentation - “Location and fluorescent behavior of NBD-labeled fatty amines in POPC:Chol and SpM:Chol bilayers”, Hugo Filipe, Tiago Palmeira, Renato Cardoso, Luis Loura and Maria João Moreno.
Congress
9th European Biophysics Congress, EBSA2013
2010/02 - 2010/02 54th Annual Meeting of Biophysical Society, San Francisco, California, USA, February 2010. - Poster Presentation - “New Method for the Measurement of Binding Constants for Amphiphiles with a Very Small Solubility in Aqueous Media”, Hugo L. Filipe, Winchil L.C. Vaz, Maria João Moreno.
Congress
54th Annual Meeting of Biophysical Society
2008/07 - 2008/07 1st Portuguese-Spanish-British Joint Biophysics Congress, Lisboa, Portugal, July 2008. - Poster Presentation - "Quantitative Modeling of Passive Permeation through the Blood Brain Barrier", Hugo Filipe, Maria João Moreno, Winchil L.C. Vaz, Armindo Salvador.
Congress
1st Portuguese-Spanish-British Joint Biophysics Congress

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/12 INTERAÇÃO DO ANTIBIÓTICO RIFAMPICINA COM MEMBRANAS LIPÍDICAS - CARACTERIZAÇÃO EXPERIMENTAL E SIMULAÇÕES DE DINÂMICA MOLECULAR
(Thesis) Main arguer
Rui Miguel Simões Santos (Master)
Universidade de Coimbra, Portugal
2021/09 Avaliação in vitro do potencial terapêutico de novos compostos contra a tuberculose
(Thesis) Main arguer
Joana Filipa Portugal da Rocha Terreiro (Other)
Universidade de Lisboa, Portugal

Association member

Society Organization name Role
2021 - Current Portuguese Biophysics Society - Fiscal Council - Vogal Fiscal Council - Vogal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - 2022 Spectroscopic Methods - Degree in Medicinal Biotechnology, 2nd year, 1st semester. Métodos Espectroscópicos - Licenciatura em Biotecnologia Medicinal, 2º ano, 1º semestre. (Licenciatura) Instituto Politécnico da Guarda, Portugal
2021 - 2022 Design and Molecular Modeling - Degree in Medicinal Biotechnology, 2nd year, 2nd semester. Design e Modelação Molecular - Licenciatura em Biotecnologia Medicinal, 2º ano, 2º semestre. (Licenciatura) Instituto Politécnico da Guarda, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021/12/30 - Current ChemEngineering MDPI
2021/11/16 - Current PlosOne Plos
2021/10/26 - Current Toxics MDPI
2021 - Current Membranes MDPI
2021 - Current Molecules MDPI
2019 - Current Journal of Colloid and Interface Science (1095-7103) Elsevier
2019 - Current International Journal of Molecular Sciences (1422-0067) MDPI AG
2017 - Current Journal of Molecular Liquids (0167-7322) Elsevier
2017 - Current Soft Materials (1539-4468) Informa UK (Taylor & Francis)
2017 - Current Experimental Physiology (0958-0670) Wiley (The Physiological Society)
2017 - Current Surface and Interface Analysis (1096-9918) Wiley (John Wiley & Sons)
2017 - Current BioMed Research International (2314-6141) Hindawi Limited
2014 - Current Journal of Molecular Structure (0022-2860) Elsevier
Distinctions

Other distinction

2021 Article selected for inside front cover of Scientific Journal, DOI: 10.1039/D1SM00590A.
2019 Article selected for the list of 2018 PCCP HOT Articles, 2018: DOI: 10.1039/C5CP05238F
2018 Article selected for inside back cover of Scientific Journal: DOI: 10.1039/C5CP05238F
2018 Recipient of the “EBSA Bursary” with the work entitled “Quantitative assessment of methods often used to obtain rate constants from biomolecular simulations” 6th International Iberian Biophysics Congress, Castellón, Spain.
2016 Article selected for inside back cover of Scientific Journal: DOI: 10.1039/C5CP05238F.
2015 Article selected for front page of Scientific Journal: DOI: 10.1039/c5cp01596k.
2010 Recipient of the “2010 International Travel Award” with the work entitled “New Method for the Measurement of Binding Constants for Amphiphiles with a Very Small Solubility in Aqueous Media” in the Biophysical Society 54th Annual Meeting, February 2010.
2009 Prémio Professor Doutor Andrade Gouveia 2008-2009
2009 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal