Ana Nobre (741A-66C0-AB57)

Curriculum Vitae

Ana Nobre

Ana Nobre is the Lab Manager at the Advanced Cell Technology Lab (ACT Lab), led by PI Hugo Fernandes at the Multidisciplinary Institute of Ageing (MIA-Portugal). As the most senior member after the PI, she assists in lab and project management, lab meetings, student mentoring, and dissemination activities. Ana holds a PhD in Biochemistry (Microbiology specialization) from the Faculty of Science and Technology, University of Coimbra (2012), as well as a Master’s in Molecular and Cellular Biology and a Bachelor’s in Biology (2007 and 2002, respectively). After her Bachelor's, Ana worked on various scientific projects, including medical microbiology research on yeast populations from immunocompromised patients and studies on stress molecules (compatible solutes) used by microorganisms. During her PhD, she focused on molecular mechanisms of microbial and plant adaptation to extreme temperatures and drought, particularly the characterization of key enzymes involved in the synthesis and hydrolysis of compatible solutes. Following a career break due to maternity leave (Jul 2012–Sept 2013), Ana pursued postdoctoral research at the Genomic Unit (UC-Biotech, Cantanhede), investigating microbial diversity in grapevines. This project partnered with the Magnomics Start-up, aiming to develop a microfluidics platform for molecular nucleic acid analysis. Between 2015 and 2017, Ana worked in the industry at Crioestaminal SA/GeneLab (Biocant Park, Cantanhede), contributing to cryopreservation laboratory activities and promoting a prenatal diagnostic test for early fetal chromosomal disorder detection. In 2018, she joined the Laboratory of Microbiology (Biocant Park) to perform microbiological quality control, particularly implementing ISO 11731:2017 for Legionella spp. isolation in water samples. In 2019, Ana returned to academia as a contracted researcher at iBiMED, studying tissue-specific aggregation-prone proteins in mammals and the molecular mechanisms behind widespread proteome aggregation during aging. Her research aims to identify novel proteostasis-related genes and age-related disease gene signatures through proteomics and genomics analysis. Ana has six peer-reviewed publications (three as first author), one book chapter ("Marine Enzymes for Biocatalysis"), and multiple international conference abstracts. In 2019, she became a FELASA-accredited Category A, B, and D Specialist and contributed as a qPCR data analyst in iBiMED’s SARS-COV2 testing task force. She has been involved in student supervision, lab rotations, and teaching Functional and Organic Systems I, III, and IV in the Biomedicine degree (Department of Health Sciences, UA). Additionally, she actively participates in science outreach initiatives such as Aveiro TechDays, Xperimenta UA, UA-Summer Academy, and European Researchers' Night. Ana has engaged in entrepreneurship and technology transfer activities, participating in the 2nd Edition Seed Tech Transfer program (UC Business, 2023), which fosters R&D commercialization. In 2024, she became a GreenKeeper at GreenLabs CiBB, promoting sustainable lab practices to minimize the environmental impact of scientific research.

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Identification

Personal identification

Full name: Ana Nobre

Citation names

Nobre, Ana

Author identifiers

Ciência ID: 741A-66C0-AB57
ORCID iD: 0000-0001-9277-6030

Email addresses

ananobre@uc.pt (Professional)

Knowledge fields

Medical and Health Sciences - Health Sciences
Natural sciences - Biological Sciences - Microbiology
Natural sciences - Biological Sciences - Molecular Biology
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Elementary (A2)	Elementary (A2)	Elementary (A2)	Elementary (A2)	Elementary (A2)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Beginner (A1)	Intermediate (B1)	Beginner (A1)

Education

	Degree	Classification
2023/02/08 - 2023/03/29 Concluded	Seed Tech Transfer, UC Business, 2.ª Edição (27 hours) (Outros) Universidade de Coimbra, Portugal
2021/01/27 - 2021/02/10 Concluded	Study Smart course (Outros) Universidade de Aveiro Departamento de Ciências Médicas, Portugal Maastricht University’s institute for education innovation, Netherlands
2019/09/09 - 2019/09/20 Concluded	FELASA Accredited Course in Laboratory Animal Science (accredited for functions (A), (B) AND (D) according directive 2010/63/EU) (Título de especialista) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Approved
2017/10/19 - 2017/12/21 Concluded	Empreendedorismo e Gestão de projetos (300 hours) (Outros) Instituto do Emprego e Formação Profissional, Portugal
2015/09/14 - 2015/12/07 Concluded	Curso de Iniciação à Programação Informática em C/C++ (300 hours) (Outros) Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal Instituto do Emprego e Formação Profissional, Portugal
2014/09/09 - 2014/11/26 Concluded	Certificate of Pedagogical Skills (CCP) N.º F630458/2015 (150 hours) (Outros) Forseguro – Formação e Segurança é uma entidade formadora certificada pela DGERT, Portugal
2014/04/03 - 2014/04/16 Concluded	Curso de Formação Profissional de Competências Empreendedoras e Técnicas de Procura de Emprego (25 hours) (Outros) Instituto do Emprego e Formação Profissional, Portugal
2012/07 - 2013/09 Concluded	High-risk pregnancy and Maternity leave (Licence) Maternidade Daniel de Matos, Portugal
2012 Concluded	Biochemistry (Doutoramento) Major in Microbiology Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Pathways for the Synthesis and Hydrolysis of Trehalose, Mannosylglycerate and Glucosylglycerate in the bacterium Rubrobacter xylanophilus and in the plant Selaginella moellendorffii" (THESIS/DISSERTATION)	Approved with distinction and honor by unanimity
2007 Concluded	Molecular and Cellular Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Trehalose biosynthesis in Rubrobacter xylanophilus: characterization of TPS and TPP enzymes" (THESIS/DISSERTATION)	Very Good
2006/09/01 - 2006/10/31 Concluded	Formação Básica de Socorrismo 715/FOR/2006 (50 hours) (Outros) Cruz Vermelha Portuguesa, Portugal
2002 Concluded	Biology (Scientific Area) (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "n/a" (THESIS/DISSERTATION)	15 (out of 20)

Affiliation

Science

	Category Host institution	Employer
2024/03 - Current	Science and Technology Management	Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal

2023/05 - 2023/08	Science and Technology Management	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2019/05/01 - 2021	Research Assistant (Research)	Universidade de Aveiro Instituto de Biomedicina, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2019/05 - 2021	Tutor (University Teacher)	Universidade de Aveiro Instituto de Biomedicina, Portugal

Other Careers

	Category Host institution	Employer
2015/12 - 2017/07	Técnico Superior (Técnico Superior)	Crioestaminal S.A./GeneLab, Portugal

Others

	Category Host institution	Employer
2018/09 - 2019/04	Teacher / Monitor of extracurricular classes	The Inventors, Maker Toolbox, Lda, Portugal

2018/01 - 2018/08	Higher Technician (probationary)	Laboratório de análises Microbiológicas, Portugal

2015/01 - 2015/07	Observational internship	Laboratory of Microbiology of the Centro Hospitalar e Universitário de Coimbra, Clinical Pathology Service, Portugal

2007/01 - 2010/12	PhD student	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Projects

Grant

	Designation	Funders
2015/03/09 - 2015/07/30	GENANALYZE CENTRO-07-0202-FEDER-038886 Post-doc	Fundo Europeu de Desenvolvimento Regional (FEDER) Concluded
2011 - 2013	The enigmatic mycobacterial maltokinase PTDC/BIA-BCM/112459/2009 Research Fellow Fundação para a Ciência e a Tecnologia, Portugal
2007 - 2010	Pathways for the Synthesis and Hydrolysis of Trehalose, Mannosylglycerate and Glucosylglycerate in the bacterium Rubrobacter xylanophilus and in the plant Selaginella moellendorffii SFRH/BD/28907/2006 PhD Student Fellow Fundação para a Ciência e a Tecnologia, Portugal	Concluded

Contract

	Designation	Funders
2019/05/01 - Current	WISDOM - Impact of widespread protein aggregation through mammal lifespan and implications for the development of age-related diseases PTDC/BTM-TEC/29843/2017 Researcher Universidade de Aveiro Instituto de Biomedicina, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Other

	Designation	Funders
2006 - 2007	Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp. POCI/BIA-MIC/56511/2004 Research Fellow Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2004 - 2005	HOTSOLUTES - New applications for compatible solutes from Extremophiles CRAFT, COOP-CT-2003-508644 Research Fellow European Commission Sixth Framework Programme, Belgium	Directorate-General for Research and Innovation
2002 - 2003	PYM – Pathogenic Yeast Methods - Other	Agência de Inovação — MCTES

Outputs

Publications

Book	Costa, J.; Empadinhas, N.; Alarico, S.; Nobre, A.; Albuquerque, L.; da Costa, M.S.. The biosynthesis of trehalose and sugar-glycerate compatible solutes in organisms that live in hot and saline environments. 2013.
Conference abstract	Nobre, Ana. "Gene expression dynamics of aging". Paper presented in 25th Virtual Annual Meeting Portuguese Society of Human Genetics, 2021. Submitted
Conference poster	Nobre, Ana. "The dynamics of the mouse aging transcriptome". Paper presented in 2nd GenomePT Symposium, 2021. Nobre, Ana. "Integrative characterization protein aggregation signatures during healthy liver aging". Paper presented in 2nd GenomePT Symposium, 2021. Nobre, Ana. "Proteomic analysis of tissue-specific protein aggregation signatures throughout mammalian aging". Paper presented in Protein Homeostasis in Health and Disease, 2020. Nobre, Ana. "From transcriptomics to proteomics: An integrated characterization of age-related protein aggregation throughout the mammalian lifespan". Paper presented in EMBL Conference: From Functional Genomics to Systems Biology, 2020. Nobre, Ana. "Characterization of wide-spread proteome aggregation through aging in mammals". Paper presented in Proteostasis: From organelles to organisms EMBO, 2019. Nobre, Ana. "Screening for trisomy 21 - analysis of free fetal DNA". Paper presented in Reunião da Sociedade Portuguesa de Obstetrícia e Medicina Materno-Fetal, 2016. Nobre, Ana. "Expression analysis of genes involved in trehalose pathways in Rubrobacter xylanophilus". Paper presented in MicroBiotec 2009, 2009. Nobre, Ana. "A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: characterization of the first bacterial TreT". Paper presented in XVI National Congress of Biochemistry, 2008. Nobre, Ana. "Two pathways for the synthesis of trehalose in Rubrobacter xylanophilus, an ancient desiccation-resistant thermophilic bacterium". Paper presented in MICRO’07 BIOTEC’07 - XXXIII Jornadas Portuguesas de Genética, 2007. Nobre, Ana. "Trehalose synthesis in the radiation-resistant bacterium Rubrobacter xylanophilus. Cloning, expression and properties of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase". Paper presented in 2nd FEMS Congress of European Microbiologists, 2006. Nobre, Ana. "Physiological role of trehalose in Thermus thermophilus RQ-1". Paper presented in FEMS Congress of European Microbiologists, 2003. Nobre, Ana. "Physiological role of trehalose in Thermus thermophilus". Paper presented in Extremophiles: the 4th international congress, 2002.
Journal article	Ferreira, Margarida; Francisco, Stephany; Soares, Ana Raquel; Nobre, Ana; Pinheiro, Miguel; Reis, Andreia; Sonya Neto; et al. "Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues". Aging (Albany NY) (2021): 18150-18190. https://pubmed.ncbi.nlm.nih.gov/34330884/. Margarida Ferreira; Francisco, Stephany; Ana Raquel Soares; Nobre, Ana; Miguel Pinheiro; Andreia Reis; Sonya Neto; et al. "Integration of differential gene expression with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues". Aging (2021): Under revision Nobre, Ana. "A unique glyceryl diglycoside identified in the thermophilic, radiation-resistant bacterium Rubrobacter xylanophilus". Extremophiles (2015): 10.1007/s00792-014-0723-0 Nobre, Ana. "The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies". Microbiology (2014): 10.1099/mic.0.075895-0 Nobre, Ana. "The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate". Planta (2012): 10.1007/s00425-012-1808-6 Nobre, Ana. "A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: characterization of the first bacterial TreT". J. Bacteriol. 190: 7939-7946 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-57349146679&partnerID=MN8TOARS. 10.1128/JB.01055-08 Nobre, Ana. "Osmotic adaptation of Thermus thermophilus RQ-1: lesson from a mutant deficient in the synthesis of trehalose". Journal of Bacteriology (2005): 10.1128/JB.185.20.5943-5952.2003
Thesis / Dissertation	Nobre, Ana. "Pathways for the Synthesis and Hydrolysis of Trehalose, Mannosylglycerate and Glucosylglycerate in the bacterium Rubrobacter xylanophilus and in the plant Selaginella moellendorffii". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2012. Nobre, Ana. "Biossíntese de trealose em Rubrobacter xylanophilus: caracterização das enzimas Tps e Tpp". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2007.

Other

Other output

Integration of differential gene expression with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues. 2021. Margarida Ferreira; Stephany Francisco; Ana R. Soares; Ana Nobre; Miguel Pinheiro; Andreia Reis; Sonya Neto; et al. https://doi.org/10.1101/2021.02.18.431793.
10.1101/2021.02.18.431793

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2009/12/21	A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: Properties of a rare actinobacterial TreT	VII Encontro Anual do Centro de Neurociências e Biologia Celular e Reunião Anual do Programa Doutoral em Biologia Experimental e Biomedicina CNC (Cantanhede, Portugal)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/04 - Current	Xperimenta UA - Coordination of the participation of DCM and iBiMED's researchers in the Xperimenta UA event, University of Aveiro. A science dissemination activity to show the research performed at the university for prospective students. (2019/04)	Universidade de Aveiro, Portugal
2015/05/14 - 2015/05/15	Vinha \| Wine 2020: Challenges and opportunities for innovation (2015/05/14 - 2015/05/15) Seminar (Member of the Organising Committee)	Biocant Associação de Transferência de Tecnologia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2019/07 - Current	Academia de Verão - Ocupação Científica de Jovens nas Férias - Scientific monitor for the University of Aveiro Summer Academy, an activity directed to high school students, where they have the opportunity, during the course of 1 week, to engage in the research activities developed at our laboratories and understand its scientific relevance. Meeting	Academia de Verão - Ocupação Científica de Jovens nas Férias Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - Current	Aveiro TechDays - Exhibitor of scientific outcomes of iBiMED at TechDays fair, promoted by Aveiro's city Hall. Techdays is a technology fair that promotes the best innovation initiatives centered in the promotion of better life quality. iBiMED's participation allowed the dissemination of several health-related projects, with special focus on the use of state-of-the-art technologies, such as genome sequencing and genetic screenings. Exhibition	Aveiro TechDays Câmara Municipal de Aveiro, Portugal
2015/06 - Current	Tratamento de Resíduos Perigosos course (Ambimed) Workshop	Biocant Associação de Transferência de Tecnologia, Portugal
2012/07 - Current	Microarrays Applications in Biomedicine Workshop	Biocant Associação de Transferência de Tecnologia, Portugal
2021/03/17 - 2021/03/17	This workshop was about the use of computer simulation and animal models for the study of human diseases. The program includes several presentations: The dynamics of molecular design; 2D to 3D models for cell physiology studies; Development and disease: lessons from the chicken embryo; Animal models of diseases: useful or not; Zebrafish: an animal model for environmental health studies; Animal models for the study of transgenerational and intergenerational transmission of metabolic traits and animal models of exercise in health and disease. Workshop	From in silico to animal models for the study of human diseases Universidade de Aveiro Instituto de Biomedicina, Portugal Universidade de Aveiro Departamento de Química, Portugal CITAB - Department of Veterinarian Sciences - Universidade de Trás-os-Montes e Alto Douro, Portugal
2015/06 - 2015/07	Microcalorimetry for the characterization of biomolecular interactions and stability of proteins and other biomolecules Workshop	Biocant Associação de Transferência de Tecnologia, Portugal
2008/09 - 2008/09	Molecular Genomics 2008: Advanced course series – Real-time PCR and analysis of mRNA and miRNA expression data Workshop	Universidade de Aveiro Departamento de Biologia, Portugal

Consulting

	Activity description	Institution / Organization
2020/07 - Current	Consulting activities under the scope of SARS-CoV-2 testing in the area of data analysis (qPCR) for the iBiMED Covid Task-force, responsible for SARS-CoV-2 testing for elderly homes and regional hospitals (Aveiro and Santa Maria da Feira).	Universidade de Aveiro Instituto de Biomedicina, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2018/06 - Current	Vitek 2 Compact, training course		Biocant Associação de Transferência de Tecnologia, Portugal
2006/09 - Current	Heavy metal resistance: Microbial and plant multiple dynamic equilibrium in response to heavy metal pandemonium		Universidade de Coimbra, Portugal
2006/05 - Current	I Encontro Nacional de Pós-graduação em Ciências Biológicas e V Simpósio de Pós-graduação		Universidade de Aveiro Departamento de Biologia, Portugal
2001/11 - Current	Horizontes da Genética		Universidade de Coimbra, Portugal
1995 - Current	First Certificate in English" by the University of Cambridge, International
2020 - 2021	Program based learning - Functional and Organic Systems III	Biomedical Sciences (Licenciatura)	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2020 - 2020	Program based learning - Functional and Organic Systems IV	Biomedical Sciences (Licenciatura)	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2020	Program based learning - Functional and Organic Systems I	Biomedical Sciences (Licenciatura)	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2015 - 2015	Capillary Electrophoresis		Biocant Associação de Transferência de Tecnologia, Portugal
2014 - 2014	The BIOLOG system for the identification of microorganisms and for the phenotyping of communities		Universidade de Aveiro Departamento de Biologia, Portugal
2005 - 2011	“Rotações Laboratoriais”, Practical classes	Biologia Celular (Mestrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2010	Molecular Microbiology, Practical Classes	Biochemistry (Master's degree)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - 2007	O proteossoma e a morte celular - conference integrada no Ciclo Nobel do Fórum Gulbenkian de Saúde		Fundação de Serralves, Portugal
2004 - 2007	Infection and Immunity, Practical Classes	Biology (Licenciatura) and Biochemistry (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Mentoring / Tutoring

	Topic	Student name
2020 - Current	Impact of protein aggregation through aging and in disease - OMICS analysis of high-throughput data	Stephany Francisco - PhD student
2008 - 2008	Microbiologia das especiarias: um estudo de isolamento e identificação por biologia molecular	Tânia Batista - Bachelor's Degree in Clinical Analyses and Public Heath

Distinctions

Award

2006	PhD FCT Grant - SFRH/BD/28907/2006 Fundação para a Ciência e a Tecnologia, Portugal