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Cristina Isabel Borges Dias Amaral has a degree in Biochemistry (2007) from University of Beira Interior (Portugal). In 2008, she completed her Master's Degree in Biochemistry, at the University of Beira Interior (Portugal), and in 2013, she concluded her PhD in Pharmaceutical Sciences - specialty Biochemistry, at the Faculty of Pharmacy, University of Porto (Portugal). Currently and since 2018, she is a Contracted Researcher in REQUIMTE and belongs to Drug Targets and Biomarkers Group, from UCIBIO. She was a postdoctoral research fellow in UCIBIO.REQUIMTE (2015-2018), a Master research fellow (2013-2014) and a PhD research fellow (2009-2013) at IBMC, University of Porto. She published 48 articles in international peer-reviewed journals, which have 2154 citations (Scopus), published 31 abstracts in indexed journals and have a Scopus h-index of 21. She presented 46 oral communications and 91 poster communications at international and national scientific meetings and has received 15 awards and/or honors. She currently supervises 2 PhD students. She have already co-supervised 2 international PhD students, has supervised 4 MSc students and co-supervised 1 MSc, as well as, several undergraduate students research projects. She participates and/or participated in several national and international financed projects. She works in the areas of Biological Sciences with emphasis on Biochemistry, Cell Biology, Molecular Biology and Biochemical Research Methods, as well as, on Medical and Health Sciences with emphasis on Oncology and Pharmacology. Current research is in the field of Oncobiology, more specifically, in the study of natural and synthetic compounds as new and potential anti-cancer drugs for hormone-dependent breast cancer, and their effects on signaling pathways of cell death and endocrine resistance. She is also deeply involved in understanding the biological mechanisms behind the endocrine resistance to the current treatments used in clinic, in order to find new strategies/targets to overcome resistance and improve treatment efficacy. More recently, she is also deeply involved in the study of cannabinoids and endocannabinoid signalling in Cancer and in Reproduction.
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Identification

Personal identification

Full name
Cristina Isabel Borges Dias Amaral

Author identifiers

Ciência ID
5218-6D89-EC6F
ORCID iD
0000-0003-1594-2095
Researcher Id
K-5850-2013
Scopus Author Id
55200177800
Education
Degree Classification
2015/01/01 - 2018/10/31
Concluded
 Postdoctorate (Pós-doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2013
Concluded
 Ph.D. in PHARMACEUTICAL SCIENCES - BIOCHEMISTRY SPECIALTY (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Hormone-dependent Breast and Prostate Cancers: new molecules and targets" (THESIS/DISSERTATION)
 Approved with Distinction
2008
Concluded
 Biochemistry (Mestrado integrado)
Universidade da Beira Interior, Portugal
"Estudo dos Défices da via de Biossíntese de Colesterol: implementação de uma metodologia e determinação de valores de referência de esteróis em amostras de líquido amniótico" (THESIS/DISSERTATION)
 18
2007
Concluded
 Biochemistry (Licenciatura)
Universidade da Beira Interior, Portugal
"Estudos Bioquimicos em Culturas de Células Humanas com Défice na Biossíntese de Colesterol" (THESIS/DISSERTATION)
 14
Outputs

Publications

Journal article
  1. Alves, Patrícia; Amaral, Cristina; Teixeira, Natércia; Correia-da-Silva, Georgina. "Effects of a combination of cannabidiol and delta-9-tetrahydrocannabinol on key biological functions of HTR-8/SVneo extravillous trophoblast cells". Toxicology 495 (2023): 153614. http://dx.doi.org/10.1016/j.tox.2023.153614.
    Accepted • 10.1016/j.tox.2023.153614
  2. Bezerra, Patrícia H. A.; Amaral, Cristina; Almeida, Cristina F.; Correia-da-Silva, Georgina; Torqueti, Maria Regina; Teixeira, Natércia. Corresponding author: Amaral, Cristina. "In Vitro Effects of Combining Genistein with Aromatase Inhibitors: Concerns Regarding Its Consumption during Breast Cancer Treatment". Molecules 28 13 (2023): 4893. http://dx.doi.org/10.3390/molecules28134893.
    Published • 10.3390/molecules28134893
  3. Almeida, Cristina Ferreira; Teixeira, Natércia; Valente, Maria João; Vinggaard, Anne Marie; Correia-da-Silva, Georgina; Amaral, Cristina. Corresponding author: Amaral, Cristina. "Cannabidiol as a Promising Adjuvant Therapy for Estrogen Receptor-Positive Breast Tumors: Unveiling Its Benefits with Aromatase Inhibitors". Cancers 15 9 (2023): 2517. http://dx.doi.org/10.3390/cancers15092517.
    Accepted • 10.3390/cancers15092517
  4. Roleira, Fernanda M.F.; Costa, Saul C.; Gomes, Ana R.; Varela, Carla L.; Amaral, Cristina; Augusto, Tiago V.; Correia-da-Silva, Georgina; et al. "Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7ß substituted steroids". Bioorganic Chemistry 131 (2023): 106286. http://dx.doi.org/10.1016/j.bioorg.2022.106286.
    10.1016/j.bioorg.2022.106286
  5. El-Abid, Hassan; Amaral, Cristina; Cunha, Sara C.; Correia-da-Silva, Georgina; Fernandes, José O.; Moumni, Mohieddine; Teixeira, Natércia. "Anti-cancer properties of hydroethanolic extracts of Juniperus oxycedrus L. in breast cancer cells". Journal of Herbal Medicine 37 (2023): 100614. http://dx.doi.org/10.1016/j.hermed.2022.100614.
    Published • 10.1016/j.hermed.2022.100614
  6. Amaral, Cristina; Correia-da-Silva, Georgina; Almeida, Cristina Ferreira; Valente, Maria João; Varela, Carla; Tavares-da-Silva, Elisiário; Vinggaard, Anne Marie; Teixeira, Natércia; Roleira, Fernanda M. F.. Corresponding author: Amaral, Cristina. "An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER+) Breast Cancer: Effects on Sensitive and Resistant Cell Lines". Molecules 28 2 (2023): 789. http://dx.doi.org/10.3390/molecules28020789.
    Published • 10.3390/molecules28020789
  7. Ferreira, Ricardo; Amaral, Cristina; Correia-da-Silva, Georgina; Almada, Marta; Borges, Margarida; Cunha, Sara Cristina; Fernandes, José Oliveira; Teixeira, Natércia. "Bisphenols A, F, S and AF trigger apoptosis and/or endoplasmic reticulum stress in human endometrial stromal cells". Toxicology 478 (2022): 153282. http://dx.doi.org/10.1016/j.tox.2022.153282.
    Published • 10.1016/j.tox.2022.153282
  8. Almeida, Cristina Ferreira; Teixeira, Natércia; Correia-da-Silva, Georgina; Amaral, Cristina. Corresponding author: Amaral, Cristina. "Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype". Molecules 27 1 (2022): 156. http://dx.doi.org/10.3390/molecules27010156.
    Published • 10.3390/molecules27010156
  9. Augusto, Tiago V.; Amaral, Cristina; Almeida, Cristina F.; Teixeira, Natércia; Correia-da-Silva, Georgina. "Differential biological effects of aromatase inhibitors: Apoptosis, autophagy, senescence and modulation of the hormonal status in breast cancer cells". Molecular and Cellular Endocrinology 537 (2021): 111426. http://dx.doi.org/10.1016/j.mce.2021.111426.
    Published • 10.1016/j.mce.2021.111426
  10. Augusto, Tiago V.; Amaral, Cristina; Wang, Yuanzhong; Chen, Shiuan; Almeida, Cristina F.; Teixeira, Natércia; Correia-da-Silva, Georgina. "Effects of PI3K inhibition in AI-resistant breast cancer cell lines: autophagy, apoptosis, and cell cycle progression". Breast Cancer Research and Treatment 190 2 (2021): 227-240. http://dx.doi.org/10.1007/s10549-021-06376-4.
    Published • 10.1007/s10549-021-06376-4
  11. Almeida, Cristina Ferreira; Amaral, Cristina; Augusto, Tiago V.; Correia-da-Silva, Georgina; Marques de Andrade, Camila; Torqueti, Maria Regina; Teixeira, Natércia. Corresponding author: Amaral, Cristina. "The anti-cancer potential of crotoxin in estrogen receptor-positive breast cancer: Its effects and mechanism of action". Toxicon 200 (2021): 69-77. http://dx.doi.org/10.1016/j.toxicon.2021.07.003.
    Published • 10.1016/j.toxicon.2021.07.003
  12. Amaral, Cristina; Trouille, Fabien Marc; Almeida, Cristina Ferreira; Correia-da-Silva, Georgina; Teixeira, Natércia. Corresponding author: Amaral, Cristina. "Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: Impact on aromatase and steroid receptors". The Journal of Steroid Biochemistry and Molecular Biology 210 (2021): 105876. http://dx.doi.org/10.1016/j.jsbmb.2021.105876.
    Published • 10.1016/j.jsbmb.2021.105876
  13. Almeida, Cristina Ferreira; Teixeira, Natércia; Oliveira, Ana; Augusto, Tiago V.; Correia-da-Silva, Georgina; Ramos, Maria João; Fernandes, Pedro Alexandrino; Amaral, Cristina. Corresponding author: Amaral, Cristina. "Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs". Biochimie 181 (2021): 65-76. http://dx.doi.org/10.1016/j.biochi.2020.11.023.
    Published • 10.1016/j.biochi.2020.11.023
  14. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; ... ; Amaral, Cristina; et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    Published • 10.1080/15548627.2020.1797280
  15. Amaral, Cristina; Augusto, Tiago V.; Almada, Marta; Cunha, Sara C.; Correia-da-Silva, Georgina; Teixeira, Natércia. Corresponding author: Amaral, Cristina. "The potential clinical benefit of targeting androgen receptor (AR) in estrogen-receptor positive breast cancer cells treated with Exemestane". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 5 (2020): 165661. http://dx.doi.org/10.1016/j.bbadis.2019.165661.
    Published • 10.1016/j.bbadis.2019.165661
  16. Almada, Marta; Amaral, Cristina; Oliveira, Ana; Fernandes, Pedro Alexandrino; Ramos, Maria João; Fonseca, Bruno M.; Correia-da-Silva, Georgina; Teixeira, Natercia. "Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling". Reproductive Toxicology 93 (2020): 75-82. http://dx.doi.org/10.1016/j.reprotox.2020.01.003.
    Published • 10.1016/j.reprotox.2020.01.003
  17. Ferreira Almeida, Cristina; Oliveira, Ana; João Ramos, Maria; Fernandes, Pedro A.; Teixeira, Natércia; Amaral, Cristina. Corresponding author: Amaral, Cristina. "Estrogen receptor-positive (ER+) breast cancer treatment: are multi-target compounds the next promising approach?". Biochemical Pharmacology 177 (2020): 113989. http://dx.doi.org/10.1016/j.bcp.2020.113989.
    Published • 10.1016/j.bcp.2020.113989
  18. Alves, Patrícia; Amaral, Cristina; Teixeira, Natércia; Correia-da-Silva, Georgina. "Cannabis sativa: much more beyond ¿9-tetrahydrocannabinol". Pharmacological Research 157 (2020): 104822. http://dx.doi.org/10.1016/j.phrs.2020.104822.
    Published • 10.1016/j.phrs.2020.104822
  19. Almada, M.; Alves, P.; Fonseca, B.M.; Carvalho, F.; Queirós, C.R.; Gaspar, H.; Amaral, C.; Teixeira, N.A.; Correia-da-Silva, G.. "Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells". Toxicology Letters 319 (2020): 129-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075163091&partnerID=MN8TOARS.
    Published • 10.1016/j.toxlet.2019.11.004
  20. Almada, M.; Oliveira, A.; Amaral, C.; Fernandes, P.A.; Ramos, M.J.; Fonseca, B.; Correia-da-Silva, G.; Teixeira, N.. "Anandamide targets aromatase: A breakthrough on human decidualization". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1864 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071606744&partnerID=MN8TOARS.
    Published • 10.1016/j.bbalip.2019.08.008
  21. Augusto, T.V.; Cunha, S.C.; Amaral, C.; Fernandes, J.O.; da Silva, E.T.; Roleira, F.F.M.; Teixeira, N.; Correia-da-Silva, G.. "A novel GC-MS methodology to evaluate aromatase activity in human placental microsomes: a comparative study with the standard radiometric assay". Analytical and Bioanalytical Chemistry 411 26 (2019): 7005-7013. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071309103&partnerID=MN8TOARS.
    Published • 10.1007/s00216-019-02076-7
  22. El-Abid, H.; Amaral, C.; Cunha, S.C.; Augusto, T.V.; Fernandes, J.O.; Correia-da-Silva, G.; Teixeira, N.; Moumni, M.. "Chemical composition and anti-cancer properties of Juniperus oxycedrus L. essential oils on estrogen receptor-positive breast cancer cells". Journal of Functional Foods 59 (2019): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066453806&partnerID=MN8TOARS.
    Published • 10.1016/j.jff.2019.05.042
  23. Augusto, T.V.; Amaral, C.; Varela, C.L.; Bernardo, F.; da Silva, E.T.; Roleira, F.F.M.; Costa, S.; Teixeira, N.; Correia-da-Silva, G.. "Effects of new C6-substituted steroidal aromatase inhibitors in hormone-sensitive breast cancer cells: Cell death mechanisms and modulation of estrogen and androgen receptors". Journal of Steroid Biochemistry and Molecular Biology 195 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072860604&partnerID=MN8TOARS.
    Published • 10.1016/j.jsbmb.2019.105486
  24. Roleira, F.M.F.; Varela, C.; Amaral, C.; Costa, S.C.; Correia-Da-Silva, G.; Moraca, F.; Costa, G.; et al. "C-6a- vs C-7a-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships". Journal of Medicinal Chemistry 62 7 (2019): 3636-3657. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064226283&partnerID=MN8TOARS.
    Published • 10.1021/acs.jmedchem.9b00157
  25. Amaral, Cristina; Augusto, Tiago Vieira; Tavares-da-Silva, Elisiário; Roleira, Fernanda M.F.; Correia-da-Silva, Georgina; Teixeira, Natércia. "Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance". The Journal of Steroid Biochemistry and Molecular Biology 183 (2018): 51-61. http://dx.doi.org/10.1016/j.jsbmb.2018.05.006.
    Published • 10.1016/j.jsbmb.2018.05.006
  26. Augusto, Tiago Vieira; Correia-da-Silva, Georgina; Rodrigues, Cecília M P; Teixeira, Natércia; Amaral, Cristina. Corresponding author: Amaral, Cristina. "Acquired resistance to aromatase inhibitors: where we stand!". Endocrine-Related Cancer 25 5 (2018): R283-R301. http://dx.doi.org/10.1530/erc-17-0425.
    Published • 10.1530/erc-17-0425
  27. Almada, Marta; Costa, Lia; Fonseca, Bruno Miguel; Amaral, Cristina; Teixeira, Natércia; Correia-da-Silva, Georgina. "The synthetic cannabinoid WIN-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor". Toxicology 385 (2017): 67-73. http://dx.doi.org/10.1016/j.tox.2017.04.013.
    Published • 10.1016/j.tox.2017.04.013
  28. Valente, Maria João; Amaral, Cristina; Correia-da-Silva, Georgina; Duarte, José Alberto; Bastos, Maria de Lourdes; Carvalho, Félix; Guedes de Pinho, Paula; Carvalho, Márcia. "Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of ß-keto amphetamines-related neurotoxicity". Archives of Toxicology 91 11 (2017): 3663-3676. http://dx.doi.org/10.1007/s00204-017-1984-z.
    Published • 10.1007/s00204-017-1984-z
  29. Almada, M.; Fonseca, B. M.; Amaral, C.; Diniz-da-Costa, M.; Correia-da-Silva, G.; Teixeira, N.. "Anandamide oxidative metabolism-induced endoplasmic reticulum stress and apoptosis". Apoptosis 22 6 (2017): 816-826. http://dx.doi.org/10.1007/s10495-017-1356-4.
    Published • 10.1007/s10495-017-1356-4
  30. Amaral, C.; Varela, C.L.; Maurício, J.; Sobral, A.F.; Costa, S.C.; Roleira, F.M.F.; Tavares-da-Silva, E.J.; Correia-da-Silva, G.; Teixeira, N.. "Anti-tumor efficacy of new 7a-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells". Journal of Steroid Biochemistry and Molecular Biology 171 (2017): 218-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017457908&partnerID=MN8TOARS.
    Published • 10.1016/j.jsbmb.2017.04.002
  31. Cristina Amaral; Maria Regina T. Toloi; Luis Daniel Vasconcelos; Maria José V. Fonseca; Georgina Correia-da-Silva; Natércia Teixeira; Amaral, Cristina; et al. "The role of soybean extracts and isoflavones in hormone-dependent breast cancer: aromatase activity and biological effects". Food & Function 8 9 (2017): 3064-3074. https://doi.org/10.1039/C7FO00205J.
    Published • 10.1039/C7FO00205J
  32. Varela, Carla L.; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C.; Carvalho, Rui A.; Costa, Giosuè; Alcaro, Stefano; et al. "Exploring new chemical functionalities to improve aromatase inhibition of steroids". Bioorganic & Medicinal Chemistry 24 12 (2016): 2823-2831. http://dx.doi.org/10.1016/j.bmc.2016.04.056.
    Published • 10.1016/j.bmc.2016.04.056
  33. Costa, L.; Amaral, C.; Teixeira, N.; Correia-Da-Silva, G.; Fonseca, B.M.. "Cannabinoid-induced autophagy: Protective or death role?". Prostaglandins and Other Lipid Mediators 122 (2016): 54-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957870766&partnerID=MN8TOARS.
    Published • 10.1016/j.prostaglandins.2015.12.006
  34. Almada, M.; Cunha, S.; Fonseca, B.M.; Amaral, C.; Piscitelli, F.; Di Marzo, V.; Correia-da-Silva, G.; Teixeira, N.. "Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release". BioFactors 42 3 (2016): 277-286. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979224104&partnerID=MN8TOARS.
    Published • 10.1002/biof.1270
  35. Sobral, A.F.; Amaral, C.; Correia-da-Silva, G.; Teixeira, N.. Corresponding author: Amaral, C.. "Unravelling exemestane: From biology to clinical prospects". Journal of Steroid Biochemistry and Molecular Biology 163 (2016): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962441168&partnerID=MN8TOARS.
    Published • 10.1016/j.jsbmb.2016.03.019
  36. Almada, M.; Amaral, C.; Diniz-Da-Costa, M.; Correia-Da-Silva, G.; Teixeira, N.A.; Fonseca, B.M.. "The endocannabinoid anandamide impairs in vitro decidualization of human cells". Reproduction 152 4 (2016): 351-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988967422&partnerID=MN8TOARS.
    Published • 10.1530/REP-16-0364
  37. Amaral, C.; Lopes, A.; Varela, C.L.; Da Silva, E.T.; Roleira, F.M.F.; Correia-Da-Silva, G.; Teixeira, N.. "Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane". International Journal of Biochemistry and Cell Biology 69 (2015): 183-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946406321&partnerID=MN8TOARS.
    Published • 10.1016/j.biocel.2015.10.024
  38. Varela, C.L.; Amaral, C.; Tavares Da Silva, E.; Lopes, A.; Correia-Da-Silva, G.; Carvalho, R.A.; Costa, S.C.P.; Roleira, F.M.F.; Teixeira, N.. "Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line". European Journal of Medicinal Chemistry 87 (2014): 336-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907586379&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2014.09.074
  39. Amaral, C.; Varela, C.; Correia-Da-Silva, G.; Tavares Da Silva, E.; Carvalho, R.A.; Costa, S.C.P.; Cunha, S.C.; et al. "New steroidal 17ß-carboxy derivatives present anti-5a-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line". Biochimie 95 11 (2013): 2097-2106. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885049687&partnerID=MN8TOARS.
    Published • 10.1016/j.biochi.2013.07.023
  40. Varela, C.L.; Amaral, C.; Correia-Da-Silva, G.; Carvalho, R.A.; Teixeira, N.A.; Costa, S.C.; Roleira, F.M.F.; Tavares-Da-Silva, E.J.. "Design, synthesis and biochemical studies of new 7a-allylandrostanes as aromatase inhibitors". Steroids 78 7 (2013): 662-669. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877042832&partnerID=MN8TOARS.
    Published • 10.1016/j.steroids.2013.02.016
  41. Amaral, C.; Varela, C.; Borges, M.; Tavares Da Silva, E.; Roleira, F.M.F.; Correia-Da-Silva, G.; Teixeira, N.. "Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis". Apoptosis 18 11 (2013): 1426-1436. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886434710&partnerID=MN8TOARS.
    Published • 10.1007/s10495-013-0879-6
  42. Amaral, C.; Cunha, S.C.; Fernandes, J.O.; Tavares Da Silva, E.; Roleira, F.M.F.; Teixeira, N.; Correia-Da-Silva, G.. "Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5a-reductase activity". Talanta 107 (2013): 154-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873337500&partnerID=MN8TOARS.
    Published • 10.1016/j.talanta.2012.12.045
  43. Amaral, C.; Varela, C.; Azevedo, M.; Da Silva, E.T.; Roleira, F.M.F.; Chen, S.; Correia-Da-Silva, G.; Teixeira, N.. "Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: Aromatase inhibition and autophagy". Journal of Steroid Biochemistry and Molecular Biology 135 1 (2013): 51-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873021507&partnerID=MN8TOARS.
    Published • 10.1016/j.jsbmb.2012.12.017
  44. Varela, C.; Tavares Da Silva, E.J.; Amaral, C.; Correia Da Silva, G.; Baptista, T.; Alcaro, S.; Costa, G.; et al. "New structure-activity relationships of A-and D-ring modified steroidal aromatase inhibitors: Design, synthesis, and biochemical evaluation". Journal of Medicinal Chemistry 55 8 (2012): 3992-4002. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860267099&partnerID=MN8TOARS.
    Published • 10.1021/jm300262w
  45. Amaral, C.; Borges, M.; Melo, S.; da Silva, E.T.; Correia-da-Silva, G.; Teixeira, N.. "Apoptosis and autophagy in breast cancer cells following exemestane treatment". PLoS ONE 7 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865060393&partnerID=MN8TOARS.
    Published • 10.1371/journal.pone.0042398
  46. Amaral, C.; Gallardo, E.; Rodrigues, R.; Pinto Leite, R.; Quelhas, D.; Tomaz, C.; Cardoso, M.L.. "Quantitative analysis of five sterols in amniotic fluid by GC-MS: Application to the diagnosis of cholesterol biosynthesis defects". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 878 23 (2010): 2130-2136. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955051100&partnerID=MN8TOARS.
    Published • 10.1016/j.jchromb.2010.06.010