Carina Talice Stube Herman de Sousa (3D1D-1828-6CD4)

Curriculum Vitae

Carina Talice Stube Herman de Sousa

Degree in Pharmaceutical Sciences from the Regional University of the Northwest of the State of Rio Grande do Sul-Brazil (2013) and from the Faculty of Pharmacy of the University of Porto (2019). Master in Oncology by the Institute of Biomedical Sciences Abel Salazar of the University of Porto and by the Portuguese Institute of Oncology- Porto (2015). PhD in Experimental and Clinical Pharmacology and Toxicology from the Faculty of Medicine of the University of Porto (2022). Currently Invited Assistant Professor in Department of Immunophysiology and Pharmacology ICBAS-Porto University. Blueclinical employee, collaborating in conducting phase I clinical trials.

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Identification

Personal identification

Full name: Carina Talice Stube Herman de Sousa
Gender: Female

Citation names

Herman, Carina
Herman-de-Sousa, Carina

Author identifiers

Ciência ID: 3D1D-1828-6CD4

Email addresses

carina.sousa@blueclinical.pt (Professional)
cherman@icbas.up.pt (Professional)

Addresses

Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas Abel Salazar, University of Porto. Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Professional)
Hospital da Prelada- Rua de Sarmento de Beires 153 , 4250, Porto, Porto, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Education

	Degree	Classification
2022/09/20 Concluded	Experimental and Clinical Pharmacology and Toxicology (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "MECHANISMS BEHIND THE PRO-FIBROTIC ROLE OF ADENOSINE IN HUMAN SUBCUTANEOUS FIBROBLASTS AND ITS CONTRIBUTION TO MYOFASCIAL PATHOLOGICAL CONDITIONS" (THESIS/DISSERTATION)
2015 Concluded	Master's in Oncology (Mestrado) Major in Oncologia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	17
2013/03/06 Concluded	Pharmaceutical Sciences (Licence) Universidade do Porto Faculdade de Farmácia, Portugal Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Brazil	16

Affiliation

Science

	Category Host institution	Employer
2023/01 - Current	Researcher (Research)	BlueClinical, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2023/09 - Current	Invited Assistant Professor (University Teacher)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Others

	Category Host institution	Employer
2022/07 - 2023/07	Researcher- Pharmacology and Drug Innovation	Universitätsstadt Tübingen, Germany
	Universidade do Porto Faculdade de Medicina, Portugal (...)
2021/04/01 - 2022	Researcher- Pharmacology and Drug Innovation	Universidade do Porto, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2021/03/31	Scholarship holder Doctoral Program Experimental and Clinical Pharmacology and Toxicology	Universidade do Porto Faculdade de Medicina, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014	Pharmacist	Panvel Farmácias, Brazil

2012 - 2013	Scholarship holder (Programa Ciências sem Fronteiras/Brasil-ERASMUS)	Ministério da Educação, Brazil
	Universidade do Porto Faculdade de Farmácia, Portugal
2008 - 2012	Technician (Neonatal Intensive Care Unit)	Hospital de Caridade de Ijuí, Brazil

2007 - 2012	Scholarship holder (Bachelor in Pharmaceutical Sciences)	Ministério da Educação, Brazil

Projects

Grant

	Designation	Funders
2021/04/01 - 2022/06/30	Unravelling the cellular and molecular cardiopulmonary benefits of DBH inhibition in animals with pulmonary arterial hypertension PCS/BIAL/001/2019 Research Fellow	Ongoing
2017 - 2022	"Mechanisms behind the pro-fibrotic role of adenosine in human subcutaneous fibroblasts and its contribution to myofascial pathological conditions" NORTE-69-2015-15 PhD Student Fellow	Concluded

Contract

	Designation	Funders
2023/03/01 - 2024/08/31	Purinas como biomarcadores urinários e alvos terapêuticos na isquemia/reperfusão da bexiga em doentes com obstrução urinária e hiperatividade do detrusor 2022.10707.PTDC Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020 - 2023	Center for Drug Discovery and Innovative Medicines University of Porto (MedInUP) UIDB/04308/2020 Researcher	Fundação para a Ciência e a Tecnologia Ongoing

Other

	Designation	Funders
2022/07 - Current	ALBINO- Effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome – a blinded randomized placebo-controlled parallel group multicenter trial for superiority (Phase III) Ensaio clínico com o Nº EudraCT 2016-000222-19 Research Fellow	Ongoing

Outputs

Publications

Conference poster	Herman-de-Sousa, Carina; Mariana Ribeiro; Diogo Silva; Costa, Maria Adelina; Correia-de-Sá, Paulo. "Exploring serum adenosine and adenosine deaminase as a biomarkers of fibromyalgia severity: results from a non-interventional clinical study.". Paper presented in XIII Meeting of the Brazilian Purine Club 2024. Curitiba-Brasil, November 5-8, 2024., 2024. Herman-de-Sousa, Carina. ""Unravelling Adenosine receptors signaling in rat subcutaneous fibroblasts: a novel approach to myofascial pain"". Paper presented in IJUP 2020 - Investigação Jovem na Universidade do Porto, 2020., 2020. Herman-de-Sousa, Carina. ""Adenosine A2A receptor activation promotes fibrosis by favoring pannexin-1 overexpression in human subcutaneous fibroblasts"". Paper presented in 1st European Purine Meeting 2019, 2019.
Journal article	Mathias, Lucas Solla; Herman-de-Sousa, Carina; Cury, Sarah Santiloni; Nogueira, Célia Regina; Correia-de-Sá, Paulo; de Oliveira, Miriane. "RNA-seq reveals that anti-obesity irisin and triiodothyronine (T3) hormones differentially affect the purinergic signaling transcriptomics in differentiated human adipocytes". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1868 4 (2023): 159276. http://dx.doi.org/10.1016/j.bbalip.2022.159276. 10.1016/j.bbalip.2022.159276 Bessa, Cláudia; Loureiro, Joana B.; Barros, Matilde; Isca, Vera M. S.; Sardão, Vilma A.; Oliveira, Paulo J.; Bernardino, Raquel L.; et al. "Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCd Activator". International Journal of Molecular Sciences 24 6 (2023): 5710. http://dx.doi.org/10.3390/ijms24065710. 10.3390/ijms24065710 Herman-de-Sousa, Carina; Costa, Maria Adelina; Silva, Rafaela Pedro; Ferreirinha, Fátima; Ribeiro, Severino; Correia-de-Sá, Paulo. "A2A receptor-induced overexpression of pannexin-1 channels indirectly mediates adenosine fibrogenic actions by favouring ATP release from human subcutaneous fibroblasts". Life Sciences 310 (2022): 121080. http://dx.doi.org/10.1016/j.lfs.2022.121080. 10.1016/j.lfs.2022.121080 Herman-de-Sousa, Carina; Pinheiro, Ana Rita; Paramos-de-Carvalho, Diogo; Costa, Maria Adelina; Ferreirinha, Fátima; Magalhães-Cardoso, Teresa; Ribeiro, Severino; et al. "Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers". Cells 9 3 (2020): 651. http://dx.doi.org/10.3390/cells9030651. 10.3390/cells9030651
Thesis / Dissertation	"Mechanisms behind pro-fibrotic role of adenosine in human subcutaneous fibroblasts and its contribution to myofascial pathological conditions.". PhD, Universidade do Porto Faculdade de Medicina, 2022. https://hdl.handle.net/10216/144023. Carina Talice Stube Herman de Sousa. "Targeted therapies as a strategy in the maintence treatment of ovarian cancer: systematic review and meta-analysis of randomized clinical trials". Master, 2015. https://hdl.handle.net/10216/81139.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2025/02/06	Diagnostic implications of adenosine and adenosine deaminase activity in the serum of fibromyalgia patients	55ª Reunião da Sociedade Portuguesa de Farmacologia, 43ª Reunião de Farmacologia Clínica e 24ª Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02/10	Adenosine A2A receptors promote fibrosis of the human subcutaneous tissue indirectly by Panx-1 overexpression mediating ATP release	52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia. orto Palácio by The Editory - The Editory Collection Hotels , Av. da Boavista ,1269, 4100-130 Porto, Portugal (Porto, Portugal)
2021/02/18	THE PRO-FIBROTIC ACTION OF ADENOSINE A2A RECEPTORS IN THE HUMAN DERMIS MAYBE DUE TO OVEREXPRESSION OF PANNEXIN-1 IN DETRIMENT OF CONNEXIN 43 HEMICHANNELS IN SUBCUTANEOUS FIBROBLASTS	51.ª Reunião da Sociedade Portuguesa de Farmacologia (SPF), 39.ª Reunião de Farmacologia Clínica e 20.ª Reunião de Toxicologia Portuguese Pharmacology Society (Lisboa, Portugal)
2020/02	Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers	SPF Meeting 2020 Universidade de Coimbra, Faculdade de Farmácia (Coimbra, Portugal)
2019	ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA XXXVII REUNIÃO FARMACOLOGIA CLÍNICA XVIII REUNIÃO TOXICOLOGIA Universidade do Porto, Faculdade de Farmácia (Porto, Portugal)
2018	ADENOSINE A2A RECEPTOR STIMULATES GROWTH AND TYPE I COLLAGEN PRODUCTION BY FIBROBLASTS OF THE HUMAN SUBCUTANEOUS TISSUE	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF), XXXVI Reunião de Farmacologia Clínica e XVII Reunião de Toxicologia-2018 Universidade de Lisboa, Faculdade de Medicina (Lisboa, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019/09/01 - 2020/12/18	Rat subcutaneous tissue response to inflammatory stimuli is mediated through an adenosine A2A/A3 receptors heterocomplex Co-supervisor	Mestrado em Bioquímica (Master) Faculdade de Ciências Universidade do Porto, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2022/02/09 - 2022/02/10	52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia, que se realizou de 9 a 11 de Fevereiro, no Porto. (2022/02/09 - 2022/02/11) Conference (Member of the Organising Committee)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2024/11/05 - 2024/11/08	Apresentação Poster "Exploring serum adenosine and adenosine deaminase as a biomarkers of fibromyalgia severity: results from a non-interventional clinical study" Congress	XIII Meeting of the Brazilian Purine Club
2019 - 2019	Apresentação de Poster "ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS" Meeting	First European Purine Meeting Universidade de Santiago de Compostela Facultade de Medicina e Odontoloxía, Spain

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2022	Drug-resistant diabetic erectile arterial dysfunction (DREAD): Is the purinome a novel therapeutic target? (Thesis) Main arguer	Natália Beirão de Sousa (Master) Universidade do Porto Faculdade de Ciências, Portugal
2019	HPLC analysis of the extracellular catabolism of adenine nucleotides and nucleosides in fibroblasts of the tar right ventricle (Thesis) Main arguer	Eduardo Veríssimo Sousa (Other) Universidade do Porto Faculdade de Ciências, Portugal

Committee member

	Activity description Role	Institution / Organization
2022/02/09 - 2022/02/11	52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology and 21st Meeting of Toxicology. Member	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Conference scientific committee

	Conference name	Conference host
2024/02/07 - 2024/02/09	54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology	Universidade NOVA- Lisboa

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2021/05/31 - Current	Aula Teórica, Unidade Curricular de Farmacologia Molecular e Celular. "Transmembrane transport: hemichannels and P-glycoprotein"	Mestrado Bioquímica- Universidade do Porto (Mestrado)	Faculdade de Ciências Universidade do Porto, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/05/16 - 2023/05/19	10º Congresso Internacional em Saúde: Empreendedorismo e Inovação " Palestra: Desenvolvimento pré-clínico e clínico de fármacos em Portugal"	Farmácia (Licence)	Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Brazil
2021/04/19 - 2021/04/19	Aula prática: Módulo "Live Cell Imaging"- Measurements of intracellular Ca2+ using calcium-sensitive dyes: microplate reader	Mestrado em Neurobiologia	Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/11/25 - 2020/11/25	Open Class Presentation: "Molecular Pharmacology in the Research of New Drugs for the Treatment of Musculoskeletal Diseases". Pharmacy Course - Regional University of the Northwest of the State of Rio Grande do Sul- Brazil. November 2020.	Farmácia (Licence)	Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Brazil

Other jury / evaluation

	Activity description	Institution / Organization
2022 - Current	Juri Ano Probatório de Doutoramento Mestre Rafael António Vale Lopes Neiva "Role of the Purinome in the Crosstalk Between Cardiomyocytes and Fibroblasts Underlying Right Ventricle Remodeling in Pulmonary Arterial Hypertension"	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal