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I've completed PhD in Structural Biology in 2002 and presently hold a position as Research Assistant Professor at UCIBIO-NOVA, started in 2003. My present research interests are focused in the search for uncharacterised biological protein-carbohydrate interactions with potential biotechnological use in nutrition, in pharma and in the biofuel industry. For this, among other structural biology and biophysics methods, I use the powerful information provided by X-ray Crystallography, that allows drawing conclusions related to macromolecular interactions, either protein-protein or protein-ligand. Additionally, I've also been strongly dedicated to the study of the phenomena behind protein crystallisation and new methods to improve it. I have completed the supervision of 3 PhD students (one awarded the Antonio Xavier Prize for the Best Thesis in 2013) and presently supervise 3 PhD students, from the MolBios and Biochemistry Doctoral programs, 1 of them concluding her Thesis in 2020. I have also trained 6 MSc students, 5 hired Post-Doctoral Fellows, and 14 other post-graduate students. Additionally, I have tutored 18 under-graduate students. In the beginning of my contract as Researcher, I held a contract as Invited Assistant Professor of FCT-NOVA, for 5 years. Additionally, I was a member of the Scientific Council of FCT-NOVA, from 2012 to 2015. I keep a regular support to 2nd and 3rd cycles in the Biochemistry section in FCT-NOVA and other institutions, when invited. I have organised several hands-on advanced courses, notably 2 editions (2014 and 2015) of the Instruct-ERIC/COST-supported international course ISBIO (https://eventos.fct.unl.pt/isbio) and a 3rd edition to be held in July 2020. As Principal Investigator, I have coordinated 4 national FCT-MCTES funded projects and was member of team in 12 other projects. I have also integrated the winning teams of the Santander-Totta Scientific Merit Award, in 2012, and the Bluepharma Innovation Award, in 2013. Up to January 2020, my research activity has produced 46 peer-reviewed publications and 5 book chapters, 20 invited and 17 co-authored oral communications. I have co-authored more than 80 poster communications (6 awarded as Best Poster). I’m Guest Editor of a Special Issue from open access journal Crystals (MDPI Publishers; https://www.mdpi.com/journal/crystals/special_issues/novel_protein). Citation metrics in ResearchID (G- 5638-2011) indicate 47 articles with citation data, with more than 1198 citations and an h-index of 18. As science outreach activities, I have dynamized the celebrations of the International Year of Crystallography, in 2014, and the International Year of Chemistry, in 2011. From 2006-2012, I was regular translator of the Science-in-School magazine. I maintain the group's social network website (https://www.facebook.com/XtalNOVA) and my own (https://docentes.fct.unl.pt/almc/). From January 2020, I was assigned duties as Ambassador for the Science Communication & Outreach of the XTAL research lab.
Identification

Personal identification

Full name
Ana Luisa Moreira de Carvalho
Date of birth
1972/08/07

Citation names

  • Carvalho, Ana Luísa
  • Carvalho, Ana L.
  • Carvalho, AL

Author identifiers

Ciência ID
351C-DCB9-6912
ORCID iD
0000-0002-3824-0240
Google Scholar ID
IQgJcAAAAJ
Researcher Id
G-5638-2011
Scopus Author Id
57195976906

Email addresses

  • almc@fct.unl.pt (Professional)

Telephones

Telephone
  • 2948300 Ext.: 10940 (Professional)

Addresses

  • UCIBIO, Departamento de Quimica, FCT-UNL, 2829-516, Caparica, Almada, Portugal (Professional)

Websites

  • https://www.facebook.com/XtalNOVA (Social media)
  • http://docentes.fct.unl.pt/almc (Scholar)
  • https://sites.fct.unl.pt/xtal/ (Scholar)
  • https://research.unl.pt/en/persons/ana-luisa-carvalho(671f7779-7995-4ac5-937e-c5293aea20ee).html (Scholar)
  • http://orcid.org/0000-0002-3824-0240 (Professional)
  • http://www.researcherid.com/rid/G-5638-2011 (Professional)
  • http://www.ucibio.pt/people/ana-luisa-carvalho (Professional)
  • https://publons.com/researcher/1327109/ana-luisa-carvalho/publications/ (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemical Research Methods

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Elementary (A2) Advanced (C1) Intermediate (B1) Intermediate (B1) Beginner (A1)
Spanish; Castilian Upper intermediate (B2) Proficiency (C2) Intermediate (B1) Proficiency (C2) Beginner (A1)
Education
Degree Classification
2002/12/01 - 2003/11/14
Concluded
Structural characterization of cellulosomal protein complexes: study of function and assembly mechanisms (Pós-doutoramento)
Major in Structural Biology
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade Nova de Lisboa, Portugal
1998/02/01 - 2002/11/05
Concluded
Biochemistry (Doutoramento)
Major in Structural Biology
Universidade Nova de Lisboa, Portugal

Centro de Investigaciones Biológicas, Spain
"Caracterização Estrutural e Bioquímica de uma Protease de Serina (Calicreína) Isolada do Plasma Seminal de Cavalo." (THESIS/DISSERTATION)
Approved by unanimity
1996/09/01 - 1998/01/31
Concluded
MSc in Biophysics and Biomedical Enginneering (Mestrado)
Major in Biophysics
Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal
"aSFP, an acidic Seminal Fluid Protein: crystallization, heavy-atom derivatization and X-ray diffraction data collection" (THESIS/DISSERTATION)
A, Very Good
1989/09/01 - 1992/06/01
Concluded
Degree of Proficiency in English (Diploma de especialização)
British Council Lisbon, Portugal
Grade C
Affiliation

Science

2003/11/15 - Current Auxiliary Researcher (Research)
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2002 - 2003 Postdoc (Research)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2000/03 - 2000/04 Research Trainee (Research)
Centro de Investigaciones Biológicas, Spain
2000 - 2000 Research Trainee (Research)
Instituto de Biomedicina de Valencia, Spain
1999/06 - 1999/07 Research Trainee (Research)
Max-Planck-Institut für Biochemie, Germany
1998/11 - 1998/12 Research Trainee (Research)
Max-Planck-Institut für Biochemie, Germany
1998/03 - 1998/03 Research Trainee (Research)
Centro de Investigaciones Biológicas, Spain
1994/08 - 1994/12 Research Trainee (Research)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Teaching in Higher Education

2003/11/01 - 2007/02/28 Invited Assistant Professor (University Teacher)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Positions / Appointments

2020/02/01 - Current Member of the Scientific Commission of the Biochemistry Section
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - Current Member of the Commission for the Management of Equipment and other Resources
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015/01/01 - Current Responsible for the X-ray Diffraction Facility of UCIBIO-FCT-NOVA
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2004/01/01 - Current Coordinator of the UCIBIO team, part of the Portuguese Block Allocation Group (BAG-Portugal), at the European Synchrotron Radiation Facility (ESRF)
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015 - 2020 Substitute member of the Scientific Council of FCT-NOVA
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/10/01 - 2015/07/31 Member of the Scientific Council of FCT-NOVA
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2014 Member of the Commission for the Scientific Matters of the Scientific Council
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009/11/01 - 2012/10/31 Substitute member of the Scientific Council of FCT-NOVA
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2020 - Current GlycoMed: Uma nova geração de enzimas para a degradação de biofilmes e modulação da resposta imunitária no cancro (A new generation of enzymes for biofilm degradation and modulation of immune response to cancer)
SUBMITTED
Researcher
2020 - Current Struct4Dis: Applied Cellular Structural Biology: Molecular Views into Cell Function in Disease
SUBMITTED
Researcher
2018 - 2021 GLYCOInteract: Glycan-human microbiome interaction: glycan diversity and recognition in the human gut with impact on health and nutrition
PTDC/BIA-MIB/31730/2017
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021 Characterization of reflectin proteins and reflectin-materials
PTDC/BII-BIO/28878/2017
Researcher
Fundação para a Ciência e a Tecnologia
2018 - 2021 Destoxificação de peróxido de hidrogénio por Bactérias Patogénicas - Peroxidase tri-hémicas de E.coli como modelo
PTDC/BBB-BQB/29442/2017
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/05/01 An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition
Provided by PTCRIS: 139494
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2016 - 2018/12 Molecular determinants of bacterial cellulosome diversity in different ecological niches
Provided by PTCRIS: 144587
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2015 - 2018/11 Targeting p53 family proteins: on the route to new anticancer agents
Provided by PTCRIS: 140607
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2013 - 2016/06 Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography
125363
Provided by PTCRIS: 125363
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2013 - 2015/04 Ionic liquid-based systems for protein crystallization
129159
Provided by PTCRIS: 129159
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2011 - 2014/08 A carbohydrate microarray platform for discovery of ligands in polysaccharides recognised by microbial carbohydrate-binding modules.
Provided by PTCRIS: 112537
112537
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2013 - 2014/06 Development of cohesin- microarrays for determining cohesin-dockerin specificities of novel cellulolytic species
Provided by PTCRIS: 126085
126085
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2010 - 2013/06 The Cellulosome assembly: structure, function and specificity of new cellulases and supramolecular complexes
Provided by PTCRIS: 100359
100359
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2009 - 2011/12 Structure and function of novel carbohydrate-binding modules and cohesin-dockerin protein complexes from Clostridium thermocellum
69732
Provided by PTCRIS: 69732
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2008 - 2011/09 A combined approach of X-ray Crystallography, NMR and Computational Chemistry for the study of the molecular interactions that define the ligand specificity in cellulosomal Carbohydrate Binding Modules
68286
Provided by PTCRIS: 68286
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2007 - 2009/04 Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes
82210
Provided by PTCRIS: 82210
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2007 - 2008/11 Structural and Functional Characterization of Nitrate Reductases and Formate Dehydrogenases
82151
Provided by PTCRIS: 82151
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
Outputs

Publications

Book chapter
  1. Carvalho, Ana Luísa. "Resistance to Aminoglycosides". 1-38. John Wiley & Sons, Ltd, 2019.
    10.1002/9781119282549.ch1
  2. Ribeiro, Diana O.; Pinheiro, Benedita A.; Carvalho, Ana Luísa; Palma, Angelina S.. "Targeting protein-carbohydrate interactions in plant cell-wall biodegradation: the power of carbohydrate microarrays". 2018.
    10.1039/9781788010641-00159
  3. Carvalho, Ana Luisa; Santos-Silva, Teresa; Romao, Maria Joao; Cabrita, Eurico J.; Marcelo, Filipa. "Structural Elucidation of Macromolecules". In Essential Techniques for Medical and Life Scientists: A Guide to Contemporary Methods and Current Applications with the Protocols, 30-91. BENTHAM SCIENCE PUBLISHERS, 2018.
    10.2174/9781681087092118010005
  4. Brás, Joana L.A.; Carvalho, Ana Luisa; Viegas, Aldino; Najmudin, Shabir; Alves, Victor D.; Prates, José A.M.; Ferreira, Luís M.A.; et al. "Escherichia coli Expression, Purification, Crystallization, and Structure Determination of Bacterial Cohesin–Dockerin Complexes". In Methods in Enzymology, 395-415. Elsevier, 2012.
    10.1016/b978-0-12-415931-0.00021-5
  5. Carvalho, Ana Luisa; Trincao, Jose; Romao, Maria Joao. "X-ray crystallography in drug discovery". In Methods in molecular biology (Clifton, N.J.), 31-56. 2010.
    Published
Journal article
  1. Carvalho, Ana Luísa. "SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations". Biochimica et Biophysica Acta (BBA) - General Subjects 1864 1 (2020): 129440-129440.
    https://doi.org/10.1016/j.bbagen.2019.129440
  2. Carvalho, Ana Luísa. "Molecular basis for the preferential recognition of ß1,3-1,4-glucans by the family 11 carbohydrate-binding module from Clostridium thermocellum". The FEBS Journal (2019):
    10.1111/febs.15162
  3. Peixoto, Daniela; Malta, Gabriela; Cruz, Hugo; Barroso, Sónia; Carvalho, Ana Luisa; Ferreira, Luisa Maria; Branco, Paula Serio. "N-Heterocyclic olefin catalysis for the ring opening of cyclic amidine compounds: a pathway to the synthesis of e-caprolactam and ¿-lactam-derived amines". The Journal of Organic Chemistry (2019):
    In press • 10.1021/acs.joc.8b02823
  4. Pedro Bule; Virgínia M. R. Pires; Victor D. Alves; Ana Luísa Carvalho; José A. M. Prates; Luís M. A. Ferreira; Steven P. Smith; et al. "Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction". Scientific Reports (2018):
    10.1038/s41598-018-25171-8
  5. Sabrina Santarsia; Ana Sofia Grosso; Filipa Trovão; Jesús Jiménez-Barbero; Ana Luísa Carvalho; Cristina Nativi; Filipa Marcelo. "Molecular recognition of a Thomsen-Friedenreich antigen mimetic targeting human galectin-3". ChemMedChem (2018):
    10.1002/cmdc.201800525
  6. Krishan Kumar; Márcia A. S. Correia; Virgínia M R Pires; Arun Dhillon; Kedar Sharma; Vikky Rajulapati; Carlos M G A Fontes; Ana Luísa Carvalho; Arun Goyal. "Novel insights into the degradation of ß-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase". International Journal Of Biological Macromolecules 117 (2018): 890-901.
    10.1016/j.ijbiomac.2018.06.003
  7. Peixoto, Daniela; Figueiredo, Margarida; Malta, Gabriela; Roma-Rodrigues, Catarina; Baptista, Pedro V.; Fernandes, Alexandra R.; Barroso, Sónia; et al. "Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H )-Anthrone". European Journal of Organic Chemistry 2018 4 (2018): 545-549.
    10.1002/ejoc.201701500
  8. Gomes, A. S.; Trovao, F.; Pinheiro, B. A.; Freire, F.; Gomes, S.; Oliveira, C.; Domingues, L.; et al. "The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding". International Journal of Molecular Sciences 19 4 (2018): 12-12.
    10.3390/ijms19041184
  9. Kryshtafovych, A.; Albrecht, R.; Basle, A.; Bule, P.; Caputo, A. T.; Carvalho, A. L.; Chao, K. L.; et al. "Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)". Proteins-Structure Function and Bioinformatics 86 (2018): 27-50.
    10.1002/prot.25392
  10. Pedro Bule; Victor D. Alves; Vered Israeli-Ruimy; Ana L. Carvalho; Luís M. A. Ferreira; Steven P. Smith; Harry J. Gilbert; et al. "Assembly of Ruminococcus flavefaciens cellulosome revealed by structures of two cohesin-dockerin complexes". Scientific Reports (2017):
    10.1038/s41598-017-00919-w
  11. Mariella Polino; Ana Luísa Carvalho; Lina Juknaite; Carla A.M. Portugal; Isabel Coelhoso; Maria João Romão; João Crespo. "Ion-Exchange Membranes for Stable Derivatization of Protein Crystals". Crystal Growth and Design 17 9 (2017): 4563-4572.
    10.1021/acs.cgd.7b00315
  12. Virgínia M R Pires; Pedro M. Pereira; Joana L A Brás; Márcia A. S. Correia; Vânia Cardoso; Pedro Bule; Victor D Alves; et al. "Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C". Journal of Biological Chemistry 292 12 (2017): 4847-4860.
    10.1074/jbc.M116.767541
  13. Magdalena Kowacz; Mateusz Marchel; Lina Juknaité; J. M. S. S. Esperança; Maria João Romão; Ana Luísa Carvalho; Luis Paulo Rebelo. "Infrared light-induced protein crystallization. Structuring of protein interfacial water and periodic self-assembly". Journal Of Crystal Growth 457 (2017): 362-368.
    10.1016/j.jcrysgro.2016.01.003
  14. dos Santos, Raquel; Carvalho, Ana Luisa; Roque, A. Cecilia A.. "Renaissance of protein crystallization and precipitation in biopharmaceuticals purification". Biotechnology Advances 35 1 (2017): 41-50.
    10.1016/j.biotechadv.2016.11.005
  15. Hussain, A.; Semeano, A. T. S.; Palma, Sicj; Pina, A. S.; Almeida, J.; Medrado, B. F.; Padua, Accs; et al. "Tunable Gas Sensing Gels by Cooperative Assembly". Advanced Functional Materials 27 27 (2017): 9-9.
    10.1002/adfm.201700803
  16. Joana L. A. Brás; Benedita Pinheiro; Kate Cameron; Fiona Cuskin; Aldino Viegas; Shabir Najmudin; Pedro Bule; et al. "Diverse specificity of cellulosome attachment to the bacterial cell surface". Scientific Reports 6 (2016): 38292-38292. https://research.unl.pt/en/publications/diverse-specificity-of-cellulosome-attachment-to-the-bacterial-cell-surface(74845819-6728-4765-8e52-ea72c70e9af4).html.
    10.1038/srep38292
  17. Magdalena Kowacz; M. Marchel; Lina Juknaité; J. M. S. S. Esperança; Maria João Romão; Ana Luísa Carvalho; Luis Paulo Rebelo. "Ionic-Liquid-Functionalized Mineral Particles for Protein Crystallization". Crystal Growth & Design 15 6 (2015): 2994-3003.
    10.1021/acs.cgd.5b00403
  18. Maria Angelina de Sá Palma; Yan Liu; Hongtao Zhang; Yibing Zhang; Barry V McCleary; Guangli Yu; Qilin Huang; et al. "Unravelling glucan recognition systems by glycome microarrays using the designer approach and mass spectrometry". Molecular & Cellular Proteomics 14 4 (2015): 974-988.
    10.1074/mcp.M115.048272
  19. Ribeiro, D.; Kulakova, A.; Quaresma, P.; Pereira, E.; Bonifacio, C.; Romao, M. J.; Franco, R.; Carvalho, A. L.. "Use of Gold Nanoparticles as Additives in Protein Crystallization". Crystal Growth & Design 14 1 (2014): 222-227.
    10.1021/cg4014398
  20. Viegas, Aldino; Sardinha, Joao; Freire, Filipe; Duarte, Daniel F.; Carvalho, Ana L.; Fontes, Carlos M. G. A.; Romao, Maria J.; et al. "Solution structure, dynamics and binding studies of a family 11 carbohydrate-binding module from Clostridium thermocellum (CtCBM11)". The Biochemical journal 451 2 (2013): 289-300. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:23356867&KeyUID=MEDLINE:23356867.
    10.1042/bj20120627
  21. Ana Luísa Carvalho; Maria João Romão; Luis Paulo Rebelo; Magdalena Kowacz; J. M. S. S. Esperança. "Hofmeister effects of ionic liquids in protein crystallization: Direct and water-mediated interactions". CrystEngComm 14 15 (2012): 4912-4921. https://research.unl.pt/en/publications/hofmeister-effects-of-ionic-liquids-in-protein-crystallization-direct-and-watermediated-interactions(eb630e57-d88e-45a4-a34d-28bcde651aad).html.
    10.1039/c2ce25129a
  22. Pinheiro, B. A.; Bras, J. L. A.; Najmudin, S.; Carvalho, A. L.; Ferreira, L. M. A.; Prates, J. A. M.; Fontes, Cmga. "Flexibility and specificity of the cohesin-dockerin interaction: implications for cellulosome assembly and functionality". Biocatalysis and Biotransformation 30 3 (2012): 309-315. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000304750500005&KeyUID=WOS:000304750500005.
    10.3109/10242422.2012.681854
  23. Bras, Joana L. A.; Alves, Victor D.; Carvalho, Ana Luisa; Najmudin, Shabir; Prates, Jose A. M.; Ferreira, Luis M. A.; Bolam, David N.; et al. "Novel Clostridium thermocellum Type I Cohesin-Dockerin Complexes Reveal a Single Binding Mode". The Journal of biological chemistry 287 53 (2012): 44394-405. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:23118225&KeyUID=MEDLINE:23118225.
    10.1074/jbc.M112.407700
  24. Bras, J. L. A.; Cartmell, A.; Carvalho, A. L. M.; Verze, G.; Bayer, E. A.; Vazana, Y.; Correia, M. A. S.; et al. "Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis". Proceedings of the National Academy of Sciences of the United States of America 108 13 (2011): 5237-5242. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288894800024&KeyUID=WOS:000288894800024.
    10.1073/pnas.1015006108
  25. Garcia-Alvarez, Begona; Melero, Roberto; Dias, Fernando M. V.; Prates, Jose A. M.; Fontes, Carlos M. G. A.; Smith, Steven P.; Romao, Maria Joao; Carvalho, Ana Luisa; Llorca, Oscar. "Molecular Architecture and Structural Transitions of a Clostridium thermocellum Mini-Cellulosome". Journal of Molecular Biology 407 4 (2011): 571-580. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288925200008&KeyUID=WOS:000288925200008.
    10.1016/j.jmb.2011.01.060
  26. Ana Luísa Carvalho; Natália de Fátima Teixeira Correia; Maria João Romão; DQ Group Author. "Real-Time Monitoring of Molecular Dynamics of Ethylene Glycol Dimethacrylate Glass Former". Journal Of Physical Chemistry B 113 43 (2009): 14209-14217. https://research.unl.pt/en/publications/realtime-monitoring-of-molecular-dynamics-of-ethylene-glycol-dimethacrylate-glass-former(fe8e55a5-aafd-4a2b-a60f-93347de9f37b).html.
    10.1021/jp903212g
  27. Freire, F.; Romão, M.J.; MacEdo, A.L.; Aveiro, S.S.; Goodfellow, B.J.; Carvalho, A.L.. "Preliminary structural characterization of human SOUL, a haem-binding protein". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65 7 (2009): 723-726. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149089746&partnerID=MN8TOARS.
    10.1107/S174430910902291X
  28. Godinho, M. H.; Filip, D.; Costa, I.; Carvalho, A. -L.; Figueirinhas, J. L.; Terentjev, E. M.. "Liquid crystalline cellulose derivative elastomer films under uniaxial strain". Cellulose 16 2 (2009): 199-205. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000263352900005&KeyUID=WOS:000263352900005.
    10.1007/s10570-008-9258-9
  29. Anjos L. Macedo; Ana Luísa Carvalho; Eurico J Cabrita; Maria João Romão. "Molecular determinants of ligand specificity in family 11 carbohydrate binding modules - an NMR, X-ray crystallography and computational chemistry approach". Febs Journal 275 10 (2008): 2524-2535. https://research.unl.pt/en/publications/molecular-determinants-of-ligand-specificity-in-family-11-carbohydrate-binding-modules--an-nmr-xray-crystallography-and-computational-chemistry-approach(1838ef96-4228-4380-9965-a5a64661ab85).html.
    10.1111/j.1742-4658.2008.06401.x
  30. José Pedro da Silva Trincão; José J. G. Moura; Pablo Javier Gonzalez; Ana Luísa Carvalho; Isabel Maria Andrade Martins Galhardas de Moura; Maria João Romão. "Heterodimeric nitrate reductase (NapAB) from Cupriavidus necator H16: purification, crystallization and preliminary X-ray analysis". Acta Crystallographica Section F-Structural Biology And Crystallization Com 63 NA (2007): 516-519. https://research.unl.pt/en/publications/heterodimeric-nitrate-reductase-napab-from-cupriavidus-necator-h16-purification-crystallization-and-preliminary-xray-analysis(d36d0822-7f80-4415-b022-3a4f09c10733).html.
    10.1107/S1744309107022129
  31. Carvalho, Ana Luisa; Dias, Fernando M. V.; Nagy, Tibor; Prates, Jose A. M.; Proctor, Mark R.; Smith, Nicola; Bayer, Edward A.; et al. "Evidence for a dual binding mode of dockerin modules to cohesins". Proceedings of the National Academy of Sciences of the United States of America 104 9 (2007): 3089-3094. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000244661400015&KeyUID=WOS:000244661400015.
    10.1073/pnas.0611173104
  32. Santos-Silva, T.; Trincão, J.; Carvalho, A.L.; Bonifácio, C.; Auchère, F.; Raleiras, P.; Moura, I.; Moura, J.J.G.; Romão, M.J.. "The first crystal structure of class III superoxide reductase from Treponema pallidum". Journal of Biological Inorganic Chemistry 11 5 (2006): 548-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745364810&partnerID=MN8TOARS.
    10.1007/s00775-006-0104-y
  33. Najmudin, S; Guerreiro, CIPD; Carvalho, AL; Prates, JAM; Correia, MAS; Alves, VD; Ferreira, LMA; et al. "Xyloglucan is recognized by carbohydrate-binding modules that interact with beta-glucan chains". Journal of Biological Chemistry 281 13 (2006): 8815-8828. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000236247100061&KeyUID=WOS:000236247100061.
    10.1074/jbc.M510559200
  34. Santos-Silva, T.; Trincão, J.; Carvalho, A.L.; Bonifácio, C.; Auchère, F.; Moura, I.; Moura, J.J.G.; Romão, M.J.. "Superoxide reductase from the syphilis spirochete Treponema pallidum: Crystallization and structure determination using soft X-rays". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61 11 (2005): 967-970. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744487895&partnerID=MN8TOARS.
    10.1107/S174430910502885X
  35. Carvalho, A.L.; Pires, V.M.R.; Gloster, T.M.; Turkenburg, J.P.; Prates, J.A.M.; Ferreira, L.M.A.; Romão, M.J.; et al. "Insights into the structural determinants of cohesin - Dockerin specificity revealed by the crystal structure of the type II cohesin from Clostridium thermocellum SdbA". Journal of Molecular Biology 349 5 (2005): 909-915. http://www.scopus.com/inward/record.url?eid=2-s2.0-20344372400&partnerID=MN8TOARS.
    10.1016/j.jmb.2005.04.037
  36. Carvalho, AL; Goyal, A; Prates, JAM; Bolam, DN; Gilbert, HJ; Pires, VMR; Ferreira, LMA; et al. "The family 11 carbohydrate-binding module of Clostridium thermocellum Lic26A-Cel5E accommodates beta-1,4- and beta-1,3-1,4-mixed linked glucans at a single binding site". Journal of Biological Chemistry 279 33 (2004): 34785-34793. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000223134800086&KeyUID=WOS:000223134800086.
    10.1074/jbc.M405867200
  37. Carvalho, AL; Dias, FMV; Prates, JAM; Nagy, T; Gilbert, HJ; Davies, GJ; Ferreira, LMA; Romao, MJ; Fontes, CMGA. "Cellulosome assembly revealed by the crystal structure of the cohesin-dockerin complex". Proceedings of the National Academy of Sciences of the United States of America 100 24 (2003): 13809-13814. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186803800015&KeyUID=WOS:000186803800015.
    10.1073/pnas.1936124100
  38. Carvalho, AL; Sanz, L; Barettino, D; Romero, A; Calvete, JJ; Romao, MJ. "Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: A homologue of human PSA". Journal of Molecular Biology 322 2 (2002): 325-337. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000178230500007&KeyUID=WOS:000178230500007.
    10.1016/S0022-2836(02)00705-2
  39. Carvalho, A. L.; Dias, J. M.; Sanz, L.; Romero, A.; Calvete, J. J.; Romao, M. J.; Carvalho, A.L.; et al. "Purification, crystallization and identification by X-ray analysis of a prostate kallikrein from horse seminal plasma". Acta Crystallographica Section D-Biological Crystallography 57 8 (2001): 1180-1183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000170041200025&KeyUID=WOS:000170041200025.
    10.1107/s0907444901009805
  40. Archer, M; Carvalho, AL; Teixeira, S; Moura, I; Moura, JJG; Rusnak, F; Romao, MJ. "Structural studies by X-ray diffraction on metal substituted desulforedoxin, a rubredoxin-type protein". Protein Science 8 7 (1999): 1536-1545. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000081271700019&KeyUID=WOS:000081271700019.
    10.1110/ps.8.7.1536
  41. Teixeira, S.; Dias, J. M.; Carvalho, A. L.; Bourenkov, G.; Bartunik, H.; Almendra, M. J.; Moura, I.; Moura, J. J. G.; Romao, M. J.. "Crystallographic studies on a tungsten-containning formate dehydrogenase from Desulfovibrio gigas". Journal of Inorganic Biochemistry 74 1-4 (1999): 89-89. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000081157700167&KeyUID=WOS:000081157700167.
  42. Romero, A.; Romao, M. J.; Varela, P. F.; Kolln, I.; Dias, J. M.; Carvalho, A. L.; Sanz, L.; TopferPetersen, E.; Calvete, J. J.. "The crystal structures of two spermadhesins reveal the CUB domain fold". Nature Structural Biology 4 10 (1997): 783-788. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997YA20300007&KeyUID=WOS:A1997YA20300007.
    10.1038/nsb1097-783
  43. Romao, M. J.; Kolln, I.; Dias, J. M.; Carvalho, A. L.; Romero, A.; Varela, P. F.; Sanz, L.; Topfer-Petersen, E.; Calvete, J. J.. "Crystal structure of acidic seminal fluid protein (aSFP) at 1.9 angstrom resolution: a bovine polypeptide of the spermadhesin family". Journal of Molecular Biology 274 4 (1997): 650-660. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071252400018&KeyUID=WOS:000071252400018.
    10.1006/jmbi.1997.1423
  44. Dias, J. M.; Carvalho, A. L.; Kolln, I.; Calvete, J. J.; TopferPetersen, E.; Varela, P. F.; Romero, A.; Urbanke, C.; Romao, M. J.. "Crystallization and preliminary x-ray diffraction studies of aSFP, a bovine seminal plasma protein with a single CUB domain architecture". Protein Science 6 3 (1997): 725-727. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997WM74000023&KeyUID=WOS:A1997WM74000023.
    10.1002/pro.5560060323

Other

Dataset
  1. My structures in the PDB. Up to Feb2020, I have co-authored 42 entries in the Protein Data Bank.. https://docentes.fct.unl.pt/almc/links/structures-protein-data-bank.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/09/04 Investigating the ligand-specificity of a Carbohydrate-Binding protein Module from Clostridium thermocellum: a biotechnological tool to target ß1,3-1,4-mixed-linked glucans GLUPOR13
Universidade do Porto, i3S (Porto, Portugal)
2019/01/09 X-Ray Crystallography in Drug Development: the case study of Galectin-3 and the Thomsen-Friedenreich Antigen Mimetic Seminar of the I3DU PhD Program
Universidade de Lisboa, Faculdade de Farmácia
2018/06/22 Investigating the carbohydrate preferences of cellulolytic bacteria 6th International Iberian Biophysics Congress
University Jaume I, Castellón (Spain)
2017/07/26 X-Ray Crystallography to investigate molecular interactions: seeing is believing Ist Symposium of the Biomolecular Engineering Lab
Biomolecular Engineering Lab, FCT-NOVA
2017/07/17 Integrative Structural Biology tools for the study of protein-ligand interactions PCISBIO Day
ITQB-NOVA
2014/08/10 The use of Gold Nanoparticles as Additives in Protein Crystallization IUCr Meeting
(Montreal, Canada)
2014/07/17 Protein-ligand interactions investigated using X-Rays and Glycoarrays PCISBIO Day
ITQB-NOVA
2011/01/14 A structural biology contribution to the understanding of bio-ethanol production Encontro REQUIMTE (Highlights Ciência2010)
REQUIMTE-FCT-NOVA
2010/07/27 Carbohydrate Binding Modules, a Driving Force behind Cellulose Recognition and Degradation in the Microbial World Session for Young Scientists at IBIO2010, BIT’s 3rd Annual World Congress of Industrial Biotechnology
(Dalian, China)
2010/07/04 A structural biology contribution to the understanding of bio-ethanol production Ciência2010
FCT-MCTES, Lisbon Congress Center (Lisbon)
2010/03/31 Protein-protein interactions determine the assembly of cellulosomes in Clostridium thermocellum Meeting Protein-Protein Interactions and Protein Folding
FCT-NOVA
2009/03/19 The Cellulosome: a nano-machine for the degradation of cellulose Conference cycle of Facolta' di Scienze - Università degli Studi di Verona
Facolta' di Scienze - Università degli Studi di Verona (Verona, Italy)
2008/02/17 The Cellulosome from Clostridium thermocellum: Building the Puzzle EMBO Practical course: Combination of electron microscopy and X-ray crystallography
(Gif-sur-Ivette, France)
2007/01/29 My research activities and scientific achievements as member of the Associate Laboratory REQUIMTE Sessões Científicas do Departamento de Química da FCT-UNL
2005/04/13 A estrutura do Cellulosoma: um mega-complexo de proteínas destinado à degradação da celulose – Um estudo por Cristalografia de Raios-X XXIV Ciclo de Conferências do DQ, Departamento de Química da FCT-UNL
2004/01/09 Cellulosome assembly and the crystal structure of the Cohesin-Dockerin complex 3º meeting ReQuimTe
FCT-NOVA
2003/09/19 Os Cristais de Proteína como Biocatalisadores DQ seminars
FCT-NOVA
2000/10/11 Protein Identification and Sequencing by Crystallography: The Crystal Structure of Horse Prostate Kallikrein at 1.42 Å resolution IBValencia Seminars
Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas (Valencia, Spain)
1999/04/07 Crystallographic studies on a Xanthine Oxidase purified from Rat Liver DQ seminars
FCT-NOVA

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019/12/01 - Current Translating the human-microbiome molecular cross-talk using glycan microarray and structural biology strategies Ref: SFRH/BD/143494/2019
Co-supervisor of Filipa Grifo Trovão
Biochemistry (PhD)
Universidade Nova de Lisboa, Portugal
2019/09/01 - Current Carbohydrate-recognition in the Human Gut – Are Bacteria friends or foes?
Co-supervisor
MSc in Biochemistry (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - Current Deciphering the human-microbiome glyco-code: an integrative approach to uncover protein-glycan interactions in the gut environment Ref: PD/BD/135517/2018
Co-supervisor of Raquel Lopes Costa
Biociências Moleculares (PhD)
Universidade Nova de Lisboa, Portugal
2015 - Current Protein-carbohydrate recognition in polysaccharide biodegradation: characterization studies using carbohydrate microarrays and macromolecular crystallography Ref: SFRH/BD/100569/2014
Co-supervisor of Diana de Oliveira Ribeiro
Bioquímica (PhD)
Universidade Nova de Lisboa, Portugal
2015 - Current Deciphering carbohydrate:protein interactions in the Human Microbiome – A combined high-throughput and structural approach Ref: PD/BD/105727/2014
Co-supervisor of Viviana Correia
Biociências Moleculares (PhD)
Universidade Nova de Lisboa, Portugal
2015 - Current Novel strategies for antibody purification through crystallization Ref: PD/BD/105753/2014
Supervisor of Raquel Santos
Biociências Moleculares (PhD)
Universidade Nova de Lisboa, Portugal
2018/02/01 - 2019/01/31 MSc Fellow hired under project PTDC/BBB-BEP/0869/2014
Supervisor of Filipa Trovão
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017/02/01 - 2018/01/31 MSc Fellow hired under project PTDC/DTP-FTO/1981/2014
Supervisor of Filipa Trovão
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017 - 2018 Post-Doctoral Fellow hired under project PTDC/BIA-MIC/5947/2012
Supervisor of Benedita Pinheiro, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2016 - 2017 Post-Doctoral Fellow hired under project PTDC/BBB-BEP/0869/2014
Supervisor of Benedita Pinheiro, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015 - 2017 Ligand discovery and structural-functional analysis of proteins involved in plant cell wall degradation
Co-supervisor of Raquel Costa
Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2016 Post-Doctoral Fellow hired under project RECI/BBB-BEP/0124/2012
Supervisor of Ramesh Pandian, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2014 - 2015 Structural characterization of glyco-proteins from the envelope of HIV-2 virus
Co-supervisor of Elizabeth Nelly Pires
Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Post-Doctoral Fellow hired under project PTDC/BBB-BEP/3058/2012
Supervisor of Lina Juknaité, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2014 - 2015 Post-Doctoral Fellow hired under project RECI/BBB-BEP/0124/2012
Supervisor of Isabel Bento, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2013 - 2014 Structural characterization of glyco-proteins from the envelope of HIV-2 virus
Supervisor of Tiago Mestre
Bioquímica (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2012 Using gold nanoparticles in protein crystallography: Studies in crystal growth and derivatization
Co-supervisor of Diana Ribeiro
Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009 - 2012 Molecular determinants of ligand specificity in carbohydrate-binding modules: an NMR and X-ray crystallography integrated study
Co-supervisor
Bioquímica (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - 2009 Structural characterization of an exocellulase from the Cellulosome of Clostridium thermocellum
Co-supervisor of Genny Verzé
Biochemistry (Master)
Università degli Studi di Verona, Italy

Event organisation

Event name
Type of event (Role)
Institution / Organization
2020/07/20 - 2020/07/25 ISBio2020: A joint Instruct-ERIC/COST Summer School on Integrative Structural Biology (2020/07/20 - 2020/07/25)
Other (Co-organisor)
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015/07/13 - 2015/07/19 ISBio2015: Integrative Structural Biology tools for the study of protein-ligand interactions (2015/07/13 - 2015/07/19)
Other (Co-organisor)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 2014, International Year of Crystallography at FCT-NOVA (http://xtal.dq.fct.unl.pt/iycr2014), includes regular conferences by national and international speakers, a photo contest (Crystals & Symmetry in Art, Science and Life) and an exhibition, from April 2014 to July 2015. (2014 - 2015)
Symposium (Member of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/10/06 - 2014/10/12 ISBio2014: Integrative Structural Biology tools for the study of protein-ligand interactions (2014/10/06 - 2014/10/12)
Other (Co-organisor)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2011 2011, International Year of Chemistry at FCT-UNL (http://www.dq.fct.unl.pt/IYC2011). (2010 - 2011)
Symposium (Member of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2018/10/30 Design and production of peptide-based scaffolds for bioengineering applications
(Thesis) Main arguer
Iana Lychko (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/12/09 Production of membrane histidine kinases and structural studies on Thiosulfate dehydrogenase
(Thesis) Main arguer
Alina Vitaliyivna Kulakova (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/06/12 Discovering novel Carbohydrate-Active Enzymes in the cellulosome of anaerobic bacteria
(Thesis) Main arguer
Vânia Ondina Pedro Fernandes (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2014/12/17 Structural and functional studies of a high activity NiFeSe hydrogenase
(Thesis) Arguer
Marta Franco Coimbra Marques (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/06/11 Deficiência na Desidrogenase dos Ésteres de Acil-Coenzima A de Cadeia Média (MCAD): caracterização de nova formas mutantes
(Thesis) Main arguer
Joana Rita Luís Nunes (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/11/20 Structure and function relationships in novel cellulosomal enzymes and cohesin-dockerin complexes
(Thesis) Main arguer
Joana Luís Armada Brás (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2012/09/21 Integrated study by NMR and X-Ray Crystallography on the analysis of the molecular interactions in Heme-Binding Proteins
Thesis Member
Filipe Miguel dos Santos Freire (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/05/28 Molecular determinants of ligand specificity in carbohydrate-binding modules: and NMR and X-ray Crystallography integrated study
Supervisor
Aldino José Martins Viegas (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/11/29 Rational use of dietary enzymes and lipids to improve broiler performance and meat quality
Thesis Member
Teresa Paula Costa Ribeiro (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2010/10/08 Biochemical and structural studies on the PhoR-PhoB two component regulatory system from Deinococcus radiodurans
(Thesis) Arguer
Sofia Maria Dias de Gouveia Caria (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/02/08 Novel insight into the mechanism of cellulosome assembly and plant cell wall hydrolysis in anaerobic bacteria
(Thesis) Main arguer
Benedita Andrade Pinheiro (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009/03/19 Expression and purification of human muscleblind-like-protein-1 and structural characterization of an exocellulase from Clostridium thermocellum
(Thesis) Main arguer
Genny Verzé (Master)
2008/11/21 Structural studies on family III alcohol dehydrogenases from pathogenic bacteria
(Thesis) Arguer
David Marçal (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007/07/25 Estrutura e função de hemicelulases e complexos coesina-doquerina: implicações na hidrólise de polissacáridos estruturais da parede celular vegetal
(Thesis) Main arguer
Fernando Manuel Vaz Dias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2006/11/13 Structural Characterization of Heme and Non-Heme Iron-Containing Proteins
Thesis Member
Teresa Sacadura Santos Silva (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Association member

Society Organization name Role
2016 - Current Sociedade Portuguesa de Química
1998 - Current Sociedade Portuguesa Biofísica

Committee member

Activity description
Role
Institution / Organization
2012 - 2014 Substitute Evacuation Coordinator of the Internal Emergency Plan of the TOMO 3 - Edifício Departamental (Chemistry wing)
Other
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Consulting

Activity description Institution / Organization
2014 - Current Web design, feed and maintenance of websites (http://sites.fct.unl.pt/xtal, https://sites.fct.unl.pt/pcisbio/, http://xtal.dq.fct.unl.pt/iycr2014, https://www.facebook.com/XtalNOVA, https://eventos.fct.unl.pt/isbio) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2005 - Current Peer-reviewing in international journals: Acta Crystallographica Section F, Crystals, Journal of Biological Inorganic Chemistry, Chemical Physics Letters, Journal of Applied Crystallography, Journal of Crystal Growth https://publons.com/researcher/1327109/ana-luisa-carvalho/peer-review/
2006 - 2012 Translation activities to Journal Science in School (http://www.scienceinschool.org/). I contribute to this project by translating to Portuguese several articles that I find of interest to young students. After translation, the articles are made available online.

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2007 - Current Support, on an yearly basis, to the Disciplines Fundamentos de Bioquímica Estrutural (undergraduate) e Bioquímica Estrutural (MSc students) (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/07/18 - 2018/07/19 Workshop Cristalografia de Raios-X, 18-19 July, UCIBIO-FCT-NOVA (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/07/13 - 2015/07/19 Co-organizer of International hands-on Course ISBio2015: Integrative Structural Biology tools for the study of protein-ligand interactions, 13-19 Julho, DQ-FCT-NOVA. INSTRUCT/COST supported training course (Outros)
2014/10/06 - 2014/10/12 Co-organizer of international hands-on Course ISBio2014: Integrative Structural Biology tools for the study of protein-ligand interactions, 6-12 October, DQ-FCT-NOVA. INSTRUCT/COST supported training course (Outros)
2012/07/11 - 2012/07/24 Summer Course 2012: Hands-On Course in Proteins and Proteomics, 11-24 July, FCT-UNL (co-organization and teaching in the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/07/11 - 2010/07/24 Summer Course 2010: Hands-On Course in Proteins and Proteomics, 11-24 July, FCT-UNL (co-organization and teaching in the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/02/01 - 2010/02/05 REQUIMTE Advanced Course 2010: Protein Crystallography, 1-5 February, FCT-UNL (co-organization and teaching). (Outros) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2009/07/07 - 2009/09/18 Summer Course 2009: Hands-On Course in Proteins and Proteomics, 7-18 September, FCT-UNL (co-organization and teaching; supervisor of the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/07/12 - 2008/07/25 Summer Course 2008: Hands-On Course in Proteins and Proteomics, 12-25 July, FCT-UNL (co-organization and teaching; supervisor of the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2000 - 2007 Curso Monográfico editions: 2007, 2004, 2001, 2000: Cristalografia de Proteínas, FCT-NOVA (co-organization and teaching). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Interview (tv / radio show)

Program Topic
2010 - 2010 Encontro Ciência2010; Session "Bio-Energia e Biocombustíveis". A structural biology contribution to the understanding of bio-ethanol production
2002 - 2002 Antena 1 PhD thesis subject
Distinctions

Award

2018 IUCr Young Scientist Award, ECM31 in Oviedo, Spain (attributed to PhD student Raquel Santos)
2016 Best poster award at GlycoSummerSchool, Groningen, Alemanha (attributed to PhD student Viviana Correia)
2015 Best poster award at GLUPOR11 (attributed to PhD student Diana Ribeiro)
2014 Best poster award at 3rd ENURS & ESRF Day (attributed to post-graduate student Viviana Correia)
Instituto Politécnico de Leiria, Portugal
2014 Best poster award at 1st FEBS-INSTRUCT Crystallization Course: Advanced methods in macromolecular crystallization VI, Nové Hrady, Czech Republic (attributed to PhD student Diana Ribeiro)
2013 Scientific Merit Prize Santander-Totta/Universidade Nova de Lisboa
Santander-Totta/Universidade Nova de Lisboa, Portugal
2013 Bluepharma / Universidade de Coimbra Innovation Award
Bluepharma, Portugal
2013 António Xavier Prize awarded to my PhD student Aldino Viegas, for the Best National Thesis in the field of NMR
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 Best poster award at the 9th Congress Carbohydrate Bioengeneering Meeting (attributed to PhD student Aldino Viegas)
2006 2nd best poster presentation award at III Bienal of GERMN (attributed to PhD student Aldino Viegas)

Title

2010 Chair of the Session for Young Scientists at IBIO2010, BIT’s 3rd Annual World Congress of Industrial Biotechnology, 24-27 July, Dalian, People’s Republic of China

Other distinction

2002 Post-doctoral scholarship SFRH/BPD/9446/2002
Fundação para a Ciência e a Tecnologia, Portugal
1998 PhD scholarship PRAXIS XXI/BD/15763/98
Fundação para a Ciência e a Tecnologia, Portugal
1996 MSc scholarship PRAXIS XXI/BM/7221/95
Fundação para a Ciência e a Tecnologia, Portugal