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First degree in Biochemistry (1992) and MSc in Biomedical Engineering (1996) from the University of Coimbra, Portugal. PhD work under Prof. Terry Jones' supervision at the MRC - Cyclotron Unit, Hammersmith Hospital in London, UK (2002). From 2000 to 2009, helped to design and supervised the construction of the Institute for Nuclear Sciences Applied to Health (ICNAS) a leading facility in Portugal for Nuclear Imaging based at the University of Coimbra. He is the current Director of the Institute and the head of the Radiochemistry Laboratory (RCL). ICNAS has extensive expertise in the development of radiopharmaceuticals for Oncology, Cardiology and Neuroscience and is fully equipped for clinical imaging (2 PET/CT and a 3T MR) as well as pre-clinical studies (including an in-house developed world leading high-resolution small animal PET with 0.3 mm resolution, a 9.4T micro-MRI, an optical imaging system and a photoacoustic tomography device). The RCL hosts 2 cyclotrons (IBA cyclone 18/9 and the first IBA Kiube variable energy, installed in 2019) and is fully licensed as a GMP manufacturing site, currently producing more than 40 different tracers based on 11C, 13N, 18F, 68Ga, 61Cu, 64Cu and 89Zr. The facility is the main supplier of PET radiopharmaceuticals for Portugal, through its subsidiary (ICNAS-Pharma, a company fully owned by the University) that currently has 7 products in the market (FDG, FCH, NaF, F-DOPA, 68Ga-DOTANOC, 68Ga-PSMA-11 and 68GaCl3). Antero's research interests include development of targeted probes for molecular imaging, PET, SPECT, radiopharmaceutical development, PET Radiopharmacy and Quality Control, pre-clinical imaging and clinical trials. The Institute is currently participating in more than 30 clinical trials, including industrial and investigator driven clinical trials. Regarding technology transfer, Antero promoted the start of 3 spin-off companies from the University of Coimbra, one of them specializes in supplying target solutions for radiometal production. He is a member of the European Pharmacopoeia Group 14 and an Expert in several Technical Committees and Field Missions for IAEA (International Atomic Energy Agency). He currently holds patents in Europe, US, Canada and Japan.
Identification

Personal identification

Full name
Antero José Pena Afonso de Abrunhosa

Citation names

  • Abrunhosa, Antero
  • Abrunhosa, Antero J

Author identifiers

Ciência ID
2E1B-49C3-207D
ORCID iD
0000-0002-4145-854X

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2002
Concluded
Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
Distinction and praise
1996
Concluded
Biomedical Engineering (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
Very Good
1992
Concluded
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Good
Affiliation

Science

Category
Host institution
Employer
2009/09/01 - Current Researcher (Research) Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2015 - 2019 Researcher (Research) CNC.IBILI, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2013 - 2015 Teacher Coordinator (Polytechnic Teacher) Escola Superior de Saúde Ribeiro Sanches, Portugal
2013 - 2015 Teacher Coordinator (Polytechnic Teacher) Escola Superior de Saúde Ribeiro Sanches, Portugal

Positions / Appointments

Category
Host institution
Employer
2017/11/22 - Current Organic Unit Director Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2017 - 2018 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra, Portugal
2017 - 2018 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra, Portugal
2017 - 2018 Diretor ou presidente da unidade orgânica Universidade de Coimbra, Portugal
2017 - 2018 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra, Portugal
2017 - 2018 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra, Portugal
2017 - 2018 Diretor ou presidente da unidade orgânica Universidade de Coimbra, Portugal
2013 - 2015 Conselho científico/técnico-científico ou orgão correspondente Escola Superior de Saúde Ribeiro Sanches, Portugal
2013 - 2015 Conselho científico/técnico-científico ou orgão correspondente Escola Superior de Saúde Ribeiro Sanches, Portugal

Others

Category
Host institution
Employer
1999/10/01 - Current Invited Professor Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
1995/10/01 - 1999/09/30 PhD student MRC Clinical Sciences Centre, United Kingdom
1992/10/01 - 1995/09/30 MSc student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1991/10/01 - 1992/09/30 First degree, Final year placement Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Projects

Grant

Designation Funders
2019/07 - Current Development of New PET Probes for the Neuropeptide Y System
PD/BDE/150334/2019
Universidade de Coimbra Faculdade de Farmácia, Portugal
Ongoing
2013 - Current From molecules to man: novel diagnostic imaging tools in neurological and psychiatric disorders
PEst-C/SAU/UI3282/2013 CENTRO-07-ST24-FEDER-00205
QREN
2012 - Current Molecular and Nano Tools for Cancer Theranostics
EXCL/QEQ-MED/0233/2012
Fundação para a Ciência e a Tecnologia
2008 - Current A novel technology for single-bed whole-body human molecular imaging with higher sensitivity and resolution
PTDC/SAU-BEB/104630/2008
Fundação para a Ciência e a Tecnologia, I.P.
2008 - Current Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation
PTDC/QUI-QUI/102049/2008
Fundação para a Ciência e a Tecnologia
2006 - Current Targeted Nanoconstructs for Multimodal Medical Molecular Imaging
PTDC/QUI/70063/2006
Fundação para a Ciência e a Tecnologia
2021/01 - 2023/12 Radiolabeled EXosomes - a nanotheranostic tool for lung micrometastasis in osteosarcoma
PTDC/BTM-SAL/4451/2020
Fundação para a Ciência e a Tecnologia
2016/07 - 2018/06 Quantification in PET: construction of a distributed non-invasive system for measuring the arterial input function
PTDC/BBB-BMD/5378/2014
Universidade de Coimbra

Contract

Designation Funders
2021 - Current New imaging biomarkers in the assessment of chronic total coronary occlusion (Novos biomarcadores de imagem na avaliação das oclusões coronárias crónicas totais)
BioImage2CTO - 39698
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade do Minho Centro de Química, Portugal
Agência Nacional de Inovação SA
Ongoing
2021 - Current New imaging biomarkers in the assessment of chronic total coronary occlusion (Novos biomarcadores de imagem na avaliação das oclusões coronárias crónicas totais)
BioImage2CTO - 39698
Agência Nacional de Inovação SA
2023/03/12 - 2026/03/11 Interação calcitonina-receptor promovida por nanopartículas guiadas por péptidos como uma nova abordagem para tratamento de glioblastoma
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2026/02/28 The Neurovascular Coupling as a biomarker and a target for cognitive enhancement in aging and vascular dementia through an innovative dietary nitrate-driven nitric oxide redox cycle: a translational study
2022.05454.PTDC
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Laboratório Associado de Sistemas Inteligentes
Universidade Nova de Lisboa Centro de Tecnologias e Sistemas, Portugal

Universidade de Aveiro Centro de Tecnologia Mecânica e Automação, Portugal

Instituto Politécnico do Porto Centro de Investigação em Sistemas Computacionais Embebidos e de Tempo-Real, Portugal

Universidade do Minho, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Matemática, Portugal

Instituto Politécnico do Cávado e do Ave, Portugal

Universidade do Porto Laboratório de Inteligência Artificial e Ciência de Computadores, Portugal

Universidade de Aveiro, Portugal

Universidade do Minho Instituto de Polímeros e Compósitos, Portugal

Universidade de Aveiro Instituto de Engenharia Eletrónica e Informática de Aveiro, Portugal

Universidade do Minho Centro ALGORITMI, Portugal

Universidade Nova de Lisboa Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial, Portugal

Universidade de Coimbra, Portugal

Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade de Coimbra Centro de Informatica e Sistemas, Portugal

Instituto Politécnico do Porto Grupo de Investigação em Engenharia e Computação Inteligente para a Inovação e o Desenvolvimento, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Intelligent Systems Associate Laboratory
LA/P/0104/2020
Universidade Nova de Lisboa Centro de Tecnologias e Sistemas, Portugal

Universidade de Aveiro Centro de Tecnologia Mecânica e Automação, Portugal

Instituto Politécnico do Porto Centro de Investigação em Sistemas Computacionais Embebidos e de Tempo-Real, Portugal

Universidade do Minho, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Matemática, Portugal

Instituto Politécnico do Cávado e do Ave, Portugal

Universidade do Porto Laboratório de Inteligência Artificial e Ciência de Computadores, Portugal

Universidade de Aveiro, Portugal

Universidade do Minho Instituto de Polímeros e Compósitos, Portugal

Universidade de Aveiro Instituto de Engenharia Eletrónica e Informática de Aveiro, Portugal

Universidade do Minho Centro ALGORITMI, Portugal

Universidade Nova de Lisboa Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial, Portugal

Universidade de Coimbra, Portugal

Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade de Coimbra Centro de Informatica e Sistemas, Portugal

Instituto Politécnico do Porto Grupo de Investigação em Engenharia e Computação Inteligente para a Inovação e o Desenvolvimento, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/06 - 2023/08 LABEL - Radio-marcação de vesiculas extracelulares para aplicações em diagnóstico e terapêuticas
POCI-01-0247-FEDER-049268
PT2020 (FEDER)
2019/09 - 2021/09 HiRezBrainPET: High Resolution Positron Emission Tomography for Brain Imaging
POCI-01-0247-FEDER-039808
PT2020 (FEDER)
2018/07/26 - 2021/07/25 Melhoria cognitiva no cérebro idoso e demência vascular em humanos através da funcionalização do acoplamento neurovascular: uma estratégia mecanística molecular promovida por nitrito e ácido ascórbico da dieta
PTDC/MED-NEU/29099/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/10 - 2020/12 VentiLab 4 COVID-19 .: Laboratório especializado no teste e certificação de equipamentos médicos respiratórios no âmbito da COVID-19
POCI-01-02B7-FEDER-069499
PT2020 (FEDER)
2017/02 - 2020/01 Synaptic networks and Personalized Medicine Approaches to Understand Neurobehavioural Diseases Across the Lifespan
SAICTPAC/0010/2015
Universidade de Coimbra
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/07 - 2019/07 DOPAPET-DCP: Development of an innovative microwave assisted synthesis process for F-DOPA
POCI-01-0247-FEDER-023747
PT2020 (FEDER)
2013/06/01 - 2015/09/30 O metilfenidato e as alterações na barreira hemato-encefálica numa situação fisiológica e na perturbação de hiperatividade com défice de atenção
PTDC/NEU-OSD/0312/2012
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - UI 3282 - 2011-2012
PEst-C/SAU/UI3282/2011
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2008/06/30 Tomógrafo PET humano de alta sensibilidade e baixo custo: testes de viabilidade
POCI/SAU-OBS/61642/2004
Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1995/10/01 - 1999/09/30 UTILIZAÇÃO DO COMPUTADOR NO PROJECTO DE MOLÉCULAS COM INTERESSE PARA UTILIZAÇÃO NO PET E NA SUA SÍNTESE AUTOMÁTICA
PRAXIS XXI/BD/4563/94
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Santos, R.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A.M.; Salgado, A.P.; Abrunhosa, A.J.; Pereira, F.C.; Seiça, R.M.; Rosário, L.M.. Bursting electrical activity generated in the presence of KATP channel blockers: Pharmacology, sensitivity to intracellular pH and modulation by glucose metabolism. 1997.
Book chapter
  1. Francisco Zagalo; Susete Fetal; Paulo Fonte; Antero Abrunhosa; Sónia Afonso; Luís Lopes; Miguel Castelo-Branco. "Development and Testing of an MRI-Compatible Immobilization Device for Head and Neck Imaging". 2024.
    10.1007/978-3-031-49018-7_44
  2. Alves, V.H.; Abrunhosa, A.J.; Castelo-Branco, M.. "Synthesis of (R)-[N-Methyl-11C]PK11195". 93-101. 2015.
Conference abstract
  1. Palma, E.; Mendes, Filipa; Guerreiro J; Campello, M.P.C.; PD Raposinho; Alves V; Abrunhosa, Antero; Paulo A. "New Cu-ATSM and Cu-GTSM Derivatives for Cancer Theranostics". Paper presented in NOVA BIOPHYSICA International Congress, Lisboa, 2019.
    Published
  2. Gonçalves, Joana; Violante, Inês R.; Sereno, José Vitor Oliveira; Leitão, Ricardo Alexandre; Cai, Y; Abrunhosa, Antero; Silva, AP; Silva, AJ; Castelo-Branco, Miguel. "The excitation/inhibition enigma in a mouse model of the autism spectrum disorder: evidence for distinct phenotypes of hippocampus and prefrontal cortex". Paper presented in 11th FENS - Forum of European Neuroscience, Berlin, 2018.
    Published
  3. Xavier, Carolina; Oliveira, Francisco; Moreira, Ana Paula; Ferreira, Rui; Mendonça, Alexandre; Verdelho, Ana; Rio, Joana; et al. "Comparação entre a PET/CT cerebral com 18F-FDG e a fase de perfusão da PET/CT com 11C-PIB". Paper presented in XVI Congresso Nacional de Medicina Nuclear, Lisboa, 2017.
    Published
  4. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, Francisco; Sereno, José; Abrunhosa, Antero; Castelo-Branco, M.; Pereira, Cláudia; Santos, Armanda. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xtg-AD mouse model". Paper presented in XIX National Congress of Biochemistry, Guimarães, 2016.
    Published
Conference paper
  1. Lapo Pais, Marta; Jorge, Lília; Martins, Ricardo; Canário, Nádia; Xavier, Carolina; Abrunhosa, Antero; Santana, Isabel; Bernardes, Rui; Castelo-Branco, Miguel. "Texture Quantification Parameters for Alzheimer's disease diagnosis measured by 11C- (R)- PK11195 PET images". Paper presented in European Journal of Nuclear Medicine and Molecular Imaging - EANM2021 - Annual Congress of the European Association of Nuclear Medicine, Online, 2021.
    Published
  2. Pereira, C.; Abrunhosa, A.; Cruz, A.; Ferreira, N.; Moreira, A.; Oliveira, F.; Patricio, M.; Caramelo, F.. "Distributed non-invasive system for measuring the arterial input function in PET". 2018.
    10.1109/NSSMIC.2017.8532753
  3. Alves, F.; Alves, V.H.; Neves, A.C.B.; Do Carmo, S.J.C.; Nactergal, B.; Hellas, V.; Kral, E.; Gonçalves-Gameiro, C.; Abrunhosa, A.J.. "Cyclotron production of Ga-68 for human use from liquid targets: From theory to practice". 2017.
    10.1063/1.4983532
  4. Cristina Serra; Angela Neves; Antero J. Abrunhosa; Luis F. Metello. "Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion". 2015.
    10.1109/enbeng.2015.7088887
  5. Serra, C.; Neves, A.; Abrunhosa, A.J.; Metello, L.F.. "Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion". 2015.
    10.1109/ENBENG.2015.7088887
  6. Serra, Cristina; Neves, Angela; Abrunhosa, Antero J.; Metello, Luis F.. "Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion". 2015.
    10.1109/ENBENG.2015.7088887
  7. Martins, P.; Blanco, A.; arques, Crespo P.; Marques, M. F. F.; Marques, R. F.; Gordo, P. M.; Kajetanowicz, M.; et al. "AN ULTRA-HIGH RESOLUTION PRECLINICAL POSITRON EMISSION TOMOGRAPHY SCANNER". 2015.
    10.1109/ENBENG.2015.7088828
  8. Serra, Cristina; Neves, Angela; Abrunhosa, Antero J.; Metello, Luis F.. "Optimization and Validation of [N-13]-NH3 Production for Clinical Studies of Positron Emission Tomography in the Evaluation of Myocardial Perfusion". 2015.
  9. Vitor H. Alves; Antero J. Abrunhosa; Miguel Castelo-Branco. "Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies". 2013.
    10.1109/enbeng.2013.6518428
  10. Alves, V.H.; Abrunhosa, A.J.; Castelo-Branco, M.. "Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies". 2013.
    10.1109/ENBENG.2013.6518428
  11. Faustino, R.; Rio, J.; Ferreira, C.; Marques, J.P.; Abrunhosa, A.J.; Ferreira, N.C.; Castelo-Branco, M.; et al. "Image analysis in radiology and nuclear medicine". 2013.
    10.1109/ENBENG.2013.6518385
  12. Faustino, R.; Rio, J.; Ferreira, C.; Marques, J. P.; Abrunhosa, A. J.; Ferreira, N. C.; Castelo-Branco, M.; et al. "Image Analysis in Radiology and Nuclear Medicine Automated Analysis of Morfology and Funtion of the Human Brain". 2013.
  13. Alves, Vitor H.; Abrunhosa, Antero J.; Castelo-Branco, Miguel. "Optimisation of Synthesis, Purification and Reformulation of (R)-[N-Methyl-C-11]PKll195 for In Vivo PET Imaging Studies". 2013.
  14. R. Faustino; A. J. Abrunhosa; M. Castelo-Branco. "Neuronal and developmental effects of high magnetic fields in the development of an intact living organism: Ceanorhabditis elegans". 2012.
    10.1109/enbeng.2012.6331363
  15. Faustino, R.; Abrunhosa, A.J.; Castelo-Branco, M.. "Neuronal and developmental effects of high magnetic fields in the development of an intact living organism: Ceanorhabditis elegans". 2012.
    10.1109/ENBENG.2012.6331363
  16. Clemente, G.; Alves, V.; Abrunhosa, A.J.. "Synthesis optimization of pittsburgh compound B by the captive solvent method". 2012.
    10.1109/ENBENG.2012.6331358
  17. Neves, S.C.; Oliveira, V.E.; Do Carmo, A.; Abrunhosa, A.J.; Botelho, M.F.; Gomes, C.M.. "Elucidation of the drug resistance mechanisms of osteosarcoma cancer stem cells with PET tracers". 2011.
    10.1109/ENBENG.2011.6026060
  18. Gomes, C.M.; Welling, M.M.; Que, I.; Henriquez, N.; Van Der Pluijm, G.; Abrunhosa, A.J.; Botelho, M.F.; et al. "Imaging multidrug resistance in osteosarcoma: A pre-clinical approach using an orthotopic animal model". 2009.
    10.1007/978-3-642-03879-2-219
Conference poster
  1. Lapo Pais, Mariana; Sereno, José Vitor Oliveira; Tomé, Vanessa A.; Fonseca, Carla; Martins, João; Fortuna, Ana; Abrunhosa, Antero; Castelo-Branco, Miguel; Gonçalves, Joana. "Negative correlation between cortical tryptophan metabolism and E/I balance in a genetic mouse model of autism spectrum disorders". Paper presented in 2nd CIBIT Meeting, 2023.
  2. Abrunhosa, Antero; Neves, Ângela; Tomé, Vanessa A.. "11C-carboxylations using Grignard reactions for the preparation of [carbonyl 11C]WAY-100635 and [1-11C]Sodium Acetate". Paper presented in 2nd CIBIT Meeting, 2023.
  3. Hrynchak, Ivanna; Silva, Magda; Silva, Sónia ; Fonseca, Alexandra; Amílcar Falcão; Abrunhosa, Antero. "GMP Production of 89Zr-DFO-Pembrolizumab for Immuno-PET: predicting response in non-small lung cancer". Paper presented in EANM, 2023.
  4. Ferreira, Hugo R. S.; Tomatis, Francesca; Almeida, Sara F.F.; Ribeiro, Ana Sofia; Ferreira, Lino; Ana Paula Silva; Moreira, João Nuno; et al. "Evaluating Blood-Brain Barrier Permeability Changes during Premetastatic Niche Formation for HER2+ Breast Cancer Brain Metastasis". Paper presented in EACR 2023 Congress, 2023.
  5. Hrynchak, Ivanna; Diana Cocioaba; Radu LEONTE; Silva, Magda; Maria-Roxana Cornoiu; Dana Niculae; Abrunhosa, Antero. "GMP Production of Copper-64 for antibody and nanobody radiolabeling: liquid vs solid target". Paper presented in 25th iSRS, 2023.
  6. Mehra, Chirag; Onwordi, Ellis; Kowalewska, Beata; Whitehurst, Thomas; Shatalina, Ekaterina; Griffioen, Gina; Martins, Ricardo; et al. "Synaptic density marker, SV2A, is reduced in autistic adults". Paper presented in INSAR meeting 2023 - International Society for Autism Research, 2023.
  7. Castelhano, Joao; Xavier, Ana Carolina; Canário, Nádia; Felix Ducker; Duarte, Isabel Catarina ; Jorge Lains; F. Carvalho; et al. "A neurostimulation and multimodal molecular imaging study of the interhemispheric inhibition/excitation imbalance in stroke". Paper presented in 5th International Brain Stimulation Conference, 2023.
  8. Lapo Pais, Mariana; Sereno, José Vitor Oliveira; Tomé, Vanessa A.; Martins, João; Abrunhosa, Antero; Gonçalves, Joana; Castelo-Branco, Miguel. "Imaging of brain tryptophan metabolism and 5-HT1A receptor density in the TSC2 mouse model: Preliminary results". Paper presented in 1º CIBIT Anual Meeting, 2022.
  9. Santos, Liliana; FERREIRA, HUGO; Tomatis, Francesca; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula Silva; et al. "Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier permeability during the pre-metastatic niche formation". Paper presented in Champalimaud Research Symposium 2022, 2022.
  10. Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Amílcar Falcão; Célia Gomes; Abrunhosa, Antero. "GMP Production of 89Zr-DFO-Trastuzumab: from chemistry to the clinic". Paper presented in New Modalities in Cancer Imaging and Therapy, 2022.
  11. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula Silva; et al. "Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a Potential Route for Brain Drug Delivery". Paper presented in 5th ASPIC International Congress, 2022.
  12. Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Falcao, Amilcar; Gomes, Celia; Abrunhosa, Antero. "Zr-89-immuno-PET imaging: from liquid target production to imaging". 2022.
  13. Almeida, Sara F.F.; Lima, Nuno; Oliveira, Rui; Martins-Marques, Tânia; Ribeiro-Rodrigues, Teresa; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; et al. "Preconditioning mice with osteosarcoma cells-derived secretome promote tumour cells engraftment and lung metastasis development". Paper presented in Tumor Microenvironment (EACR-AACR Basic and Translational Research Conference in partnership with ASPIC), 2020.
  14. Almeida, Sara F.F.; Lima, Nuno; Oliveira, Rui; Martins-Marques, Tânia; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; Amílcar, Falcão; Abrunhosa, Antero; Gomes, Célia. "Secretome derived from osteosarcoma (OS) cells promote tumour cell colonization and lung metastasis formation in pre-treated mice". Paper presented in CIBB Meeting 2019 - Universidade de Coimbra, 2019.
  15. Hrynchak, Ivanna; Ângela C.B. Neves; Pereira, M. M.; Abrunhosa, Antero; Fonseca, Inês C. F.. "Improved nucleophilic synthesis of [18F]F-DOPA using microwave technology". Paper presented in XXV Encontro Galego-Portugês de Química, Santiago de Compostela, 2019.
  16. Hrynchak, Ivanna; Neves, Ângela; Pereira, M. M.; Fonseca, Inês C. F.; Abrunhosa, Antero. "Asymmetric Synthesis of a promising [18F]F-DOPA Precursor". Paper presented in XXV Encontro Galego-Portugês de Química, Santiago de Compostela, 2019.
  17. Hrynchak, Ivanna; Neves, Ângela; Alves, Vítor H.; Pereira, M. M.; Amílcar Falcão; Abrunhosa, Antero. "Automated microwave-assisted synthesis for PET radiochemistry". Paper presented in XXV Encontro Galego-Portugês de Química, Santiago de Compostela, 2019.
  18. Almeida, Sara F.F.; Lima, Nuno; Martins-Marques, Tânia; Girao, Henrique; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; Amílcar, Falcão; Abrunhosa, Antero; Gomes, Célia. "Osteosarcoma-released bioactive factors facilitate lung metastasis by regulating cell adhesion". Paper presented in Seed and Soil: mechanisms of metastasis (2nd joint EACR-MRS conference), 2019.
  19. Lapa, Beatriz; Jorge, Joana; Alves, Raquel; Pires, Ana Salomé; Abrantes, Ana Margarida; Coucelo, Margarida; Abrunhosa, Antero; et al. "Potenciais alvos terapêuticos na leucemia mieloblástica aguda - glicólise ou oxidação fosforilativa?". Paper presented in 1º Encontro Nacional de Jovens Investigadores em Oncologia, 2019.
  20. Lapa, Beatriz; Jorge, Joana; Alves, Raquel; Pires, Ana Salomé; Abrantes, Ana Margarida; Coucelo, Margarida; Abrunhosa, Antero; et al. "Glycolysis versus oxidative phosphorylation ¿ Potential therapeutic targets in AML". Paper presented in 24º European Hematology Association Congress, 2019.
  21. Alves, F.; Alves, Vítor H.; Neves, ACB; Abrunhosa, Antero J. "GMP Production of Gallium-68 from a Cyclotron Using Liquid Targets: Regulatory Aspects". Paper presented in 22nd International Symposium on Radiopharmaceutical Sciences, 2019.
  22. Cavaleiro, Carla; Jesus, Diana; Martins, João; Abrunhosa, Antero; Castelo-Branco, Miguel; Gonçalves, Joana. "Impact of neurofibromatosis type 1 on early postnatal development: a behavioral approach.". Paper presented in XVI Meeting of the Portuguese Society for Neurocience, 2019.
  23. Martins, João; Cavaleiro, Carla; Sereno, José; Edfawy, Mohamed; Peça, João; Abrunhosa, Antero; Castelo-Branco, Miguel; Gonçalves, Joana. "Neural basis for adult cognitive deficits in neurofibromatosis type 1 animal model: Relevance for autism spectrum disorders.". Paper presented in XVI Meeting of the Portuguese Society for Neurocience, 2019.
  24. Resende, Rosa; Moreira, Patricia; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, Francisco; Sereno, José; Abrunhosa, Antero; et al. "New chimeric peptides selectively inhibit APPß cleavage decreasing Aß formation and accumulation in AD models". Paper presented in 14th International Conference on Alzheimer's & Parkinson's Diseases, Lisbon, Portugal, 2019.
  25. Ferreira, Ildete L; Maranga, Carina; Mota, Sandra I; Laço, Mário N; Sereno, José Vitor Oliveira; Abrunhosa, Antero; Hayden, Michael; Castelo-Branco, Miguel; Rego, A. Cristina. "Redox and mitochondrial function switches in striatum and cortex of pre-symptomatic and symptomatic Huntington's Disease mouse model". Paper presented in XIX National Congress of Biochemistry, 2016.
  26. Ferreira, IL; Maranga, Carina; Mota, S.I.; Laço M; Sereno, José Vitor Oliveira; Abrunhosa, Antero; Hayden M; Castelo-Branco, Miguel; Rego, Ana Cristina. "Redox and mitochondrial functional switches in striatum and cortex of pre-symptomatic and symptomatic Huntington¿s disease mouse model". Paper presented in XIX National Congress of Biochemistry by the Portuguese Society of Biochemistry, 2016.
  27. Rego, A. Cristina; Maranga, Carina; Ferreira, Ildete L; Laço, Mário N; Mota, Sandra I; Naia, L; Sereno, José Vitor Oliveira; et al. "Redox changes and bioenergetic defects in striatum and and cortex of pre-symptomatic and symptomatic Huntington's Disease mice". Paper presented in Society for Neuroscience 46th annual meeting, 2016.
  28. Rego, Ana Cristina; Ferreira, IL; Maranga, Carina; Laço Mário; Mota, S.I.; Naia Luana; Sereno, José Vitor Oliveira; et al. "Redox changes and bioenergetic defects in striatum and cortex of pre-symptomatic and symptomatic Huntington disease mice.". Paper presented in 46th Annual Meeting of Society for Neuroscience (SFN), 2016.
  29. Nuno P.F. Gonçalves; Simões, Ana V. C.; Dabrowski, Janusz; Abreu, Artur R.; Calvete, Mário J. F. ; Abrunhosa, Antero; Pereira, Mariette M.. "Synthesis of new 18F and 11C porphyrins and their potential application fo in vivo Moleucar Imaging using PET technique". Paper presented in 18th European Symposium on Organic Chemistry, 2013.
  30. Pereira, Mariette M.; Nuno P.F. Gonçalves; Simões, Ana V. C.; Abreu, Artur R.; Arnaut, Luis G.; Simões, Sérgio; Abrunhosa, Antero; Calvete, Mário J. F.. "Synthesis of carbon-11 labeled porphyrins as potential cancer biomarkers for PET imaging". Paper presented in XXIII National meeting of Portuguese Society of Chemistry, 2011.
Journal article
  1. Alexandra I. Fonseca; Sérgio J. C. Do Carmo; Ivanna Hrynchak; Vítor Alves; Francisco Alves; Antero J. Abrunhosa. "Purification of Copper Radioisotopes for Medical Applications: Chromatographic Methods and Challenges". Separation & Purification Reviews (2023): https://doi.org/10.1080/15422119.2023.2270469.
    10.1080/15422119.2023.2270469
  2. Alexandra I. Fonseca; Vítor H. Alves; Ivanna Hrynchak; Francisco Alves; Antero J. Abrunhosa. "Fully Automated Production of [68Ga]GaFAPI-46 with Gallium-68 from Cyclotron Using Liquid Targets". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms242015101.
    10.3390/ijms242015101
  3. Banerjee, Arnab; Lino, Miguel; Jesus, Carlos; Ribeiro, Quélia; Abrunhosa, Antero; Ferreira, Lino. Corresponding author: Ferreira, Lino. "Imaging platforms to dissect the in vivo communication, biodistribution and controlled release of extracellular vesicles". Journal of Controlled Release 360 (2023): 549-563. http://dx.doi.org/10.1016/j.jconrel.2023.06.039.
    Published • 10.1016/j.jconrel.2023.06.039
  4. Ivanna Hrynchak; Diana Cocioaba; Alexandra I. Fonseca; Radu Leonte; Sérgio J. C. do Carmo; Roxana Cornoiu; Amílcar Falcão; Dana Niculae; Antero J. Abrunhosa. "Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach". Molecules (2023): https://doi.org/10.3390/molecules28124670.
    10.3390/molecules28124670
  5. Lapo Pais, Marta; Jorge, Lília; Martins, Ricardo; Canário, Nádia; Xavier, Ana Carolina; Bernardes, Rui; Abrunhosa, Antero; Santana, Isabel; Castelo-Branco, Miguel. Corresponding author: Castelo-Branco, Miguel. "Textural properties of microglial activation in Alzheimer's disease as measured by (R)-[11C]PK11195 PET". Brain Communications (2023): http://dx.doi.org/10.1093/braincomms/fcad148.
    Published • 10.1093/braincomms/fcad148
  6. Hrynchak, Ivanna; Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Falcão, Amílcar; Gomes, Célia; Abrunhosa, Antero. "89Zr-immuno-PET imaging: from liquid target production to imaging". Nuclear Medicine and Biology 114-115 (2022): S23-S24. http://dx.doi.org/10.1016/s0969-8051(22)02141-2.
    10.1016/s0969-8051(22)02141-2
  7. Korde, Aruna; Mikolajczak, Renata; Kolenc, Petra; Bouziotis, Penelope; Westin, Hadis; Lauritzen, Mette; Koole, Michel; et al. "Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals". EJNMMI Radiopharmacy and Chemistry 7 1 (2022): http://dx.doi.org/10.1186/s41181-022-00168-x.
    10.1186/s41181-022-00168-x
  8. Inês C. F. Fonseca; Miguel Castelo-Branco; Cláudia Cavadas; Antero J. Abrunhosa. "PET Imaging of the Neuropeptide Y System: A Systematic Review". Molecules 27 12 (2022): 3726-3726. https://doi.org/10.3390/molecules27123726.
    10.3390/molecules27123726
  9. Alexandra I. Fonseca; Vítor Alves; Sergio JC do Carmo; Magda Silva; Ivanna Hrynchak; Francisco José Cerqueira Alves; Amílcar Falcão; Antero Abrunhosa. "Production of GMP-Compliant Clinical Amounts of Copper-61 Radiopharmaceuticals from Liquid Targets". Pharmaceuticals (2022): https://www.mdpi.com/1424-8247/15/6/723.
    10.3390/ph15060723
  10. Dewulf, Jonatan; Hrynchak, Ivanna; Fonseca, Alexandra; Silva, Magda; Vangestel, Christel; do Carmo, Sérgio; Sereno, José; et al. "Bringing personalized medicine to the next level: RANKL immuno-PET imaging using [64Cu]Cu-NOTA-anti-RANKL-Fab fragments". Nuclear Medicine and Biology 108-109 (2022): S184-S185. http://dx.doi.org/10.1016/s0969-8051(22)00385-7.
    10.1016/s0969-8051(22)00385-7
  11. Valério-Fernandes, Ângela; Fonseca, Nuno A.; Gonçalves, Nélio; Cruz, Ana F.; Pereira, Marta I.; Gregório, Ana C.; Moura, Vera; et al. "Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer". Cancers 14 9 (2022): 2217. http://dx.doi.org/10.3390/cancers14092217.
    10.3390/cancers14092217
  12. Jonatan Dewulf; Ivanna Hrynchak; Sarah Geudens; Isabel Pintelon; Christel Vangestel; José Sereno; Peter A. van Dam; et al. "Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14050939.
    10.3390/pharmaceutics14050939
  13. Fonte, Paulo; Lopes, Luis; Alves, Rui; Carolino, Nuno; Crespo, Paulo; Couceiro, Miguel; Cunha, Orlando; et al. "An RPC-PET brain scanner demonstrator: first results". ArXiv (2022): https://publons.com/wos-op/publon/62903353/.
  14. Borges-Rosa, Joao; Oliveira-Santos, Manuel; Silva, Rodolfo; da Silva, Nuno Pereira; Abrunhosa, Antero; Castelo-Branco, Miguel; Goncalves, Lino; Ferreira, Maria Joao. "Cardiac microcalcification burden: Global assessment in high cardiovascular risk subjects with Na[F-18]F PET-CT". Journal of Nuclear Cardiology (2022): https://publons.com/wos-op/publon/44808728/.
    10.1007/S12350-021-02600-2
  15. Agostinho, Daniel; Caramelo, Francisco; Moreira, Ana Paula; Santana, Isabel; Abrunhosa, Antero; Castelo-Branco, Miguel. "Combined Structural MR and Diffusion Tensor Imaging Classify the Presence of Alzheimer's Disease With the Same Performance as MR Combined With Amyloid Positron Emission Tomography: A Data Integration Approach". Frontiers in Neuroscience (2022): https://publons.com/wos-op/publon/52315927/.
    10.3389/FNINS.2021.638175
  16. Paulo J. R. Fonte; Alberto Martinho; Américo Pereira; Andreia Gomes; Ângela Neves; Antero Abrunhosa; António Bugalho; et al. "Ventilador mecânico invasivo de emergência resistente e de fácil manutenção". Revista Brasileira de Terapia Intensiva 34 3 (2022): http://dx.doi.org/10.5935/0103-507x.20220383-pt.
    10.5935/0103-507x.20220383-pt
  17. Carla Maria Nunes Lopes; Ferreira, Ildete L.; Maranga, Carina; Beatriz, Margarida; de rosa maura; Sereno, José Vitor Oliveira; Castelo-Branco, Miguel; et al. "Mitochondrial and redox modifications in early stages of Huntington¿s disease". redox modifications in early stages of Huntington¿s disease¿. Preprint (2022):
    Submitted
  18. Dewulf, Jonatan; Hrynchak, Ivanna; Fonseca, Alexandra; Silva, Magda; Vangestel, Christel; do Carmo, Sergio; Sereno, Jose; et al. "Bringing personalized medicine to the next level: RANKL immuno-PET imaging using [Cu-64]Cu-NOTA-anti-RANKL-Fab fragments". Nuclear Medicine and Biology (2022): https://publons.com/wos-op/publon/53101680/.
  19. Fonseca, Alexandra; Alves, Vitor; do Carmo, Sergio; Silva, Magda; Alves, Francisco; Abrunhosa, Antero. "Copper-61 as an alternative to Gallium-68 for radiopharmaceutical production: feasibility study and scale-up for clinical doses". Nuclear Medicine and Biology (2022): https://publons.com/wos-op/publon/53879078/.
    10.1016/S0969-8051(22)00087-7
  20. Tome, Vanessa A.; Neves, Angela C. B.; Pinto, Sara M. A.; Rodrigues, Fabio M. S.; Calvete, Mario J. F.; Alves, Vitor H. P.; Sereno, Jose; Abrunhosa, Antero J.; Pereira, Mariette M.. "Stable [Cu-64]-labelled phthalocyanine choline bioconjugate for development of a potential cancer PET probe. In vivo biodistribution evaluation". Journal of Porphyrins and Phthalocyanines (2022): https://publons.com/wos-op/publon/53190405/.
    10.1142/S1088424622500298
  21. Korde, Aruna; Mikolajczak, Renata; Kolenc, Petra; Bouziotis, Penelope; Westin, Hadis; Lauritzen, Mette; Koole, Michel; et al. "Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals". EJNMMI Radiopharmacy and Chemistry (2022): https://publons.com/wos-op/publon/53291758/.
    10.1186/S41181-022-00168-X
  22. Valerio-Fernandes, Angela; Fonseca, Nuno A.; Goncalves, Nelio; Cruz, Ana F.; Pereira, Marta I.; Gregorio, Ana C.; Moura, Vera; et al. "Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer". Cancers (2022): https://publons.com/wos-op/publon/51989969/.
    10.3390/CANCERS14092217
  23. Almeida, Sara F. F.; Fonseca, Alexandra; Sereno, Jose; Ferreira, Hugo R. S.; Lapo-Pais, Mariana; Martins-Marques, Tania; Rodrigues, Teresa; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small (2022): https://publons.com/wos-op/publon/54945209/.
    10.1002/SMLL.202203999
  24. Lopes, Carla; Ferreira, I. Luisa; Maranga, Carina; Beatriz, Margarida; Mota, Sandra I.; Sereno, Jose; Castelhano, Joao; et al. "Mitochondrial and redox modifications in early stages of Huntington's disease". Redox Biology (2022): https://publons.com/wos-op/publon/53574724/.
    10.1016/J.REDOX.2022.102424
  25. Ângela C. B. Neves; Ivanna Hrynchak; Inês Fonseca; Vítor H. P. Alves; Mariette M. Pereira; Amílcar Falcão; Antero J. Abrunhosa. "Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA". EJNMMI Radiopharmacy and Chemistry 6 1 (2021): https://doi.org/10.1186/s41181-021-00126-z.
    10.1186/s41181-021-00126-z
  26. Ivanna Hrynchak; Liliana Santos; Amílcar Falcão; Célia M. Gomes; Antero J. Abrunhosa. "Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies". International Journal of Molecular Sciences 22 19 (2021): 10745-10745. https://doi.org/10.3390/ijms221910745.
    10.3390/ijms221910745
  27. Ricardo Martins; Francisco Oliveira; Fradique Moreira; Ana Paula Moreira; Antero Abrunhosa; Cristina Januário; Miguel Castelo-Branco. "Automatic classification of idiopathic Parkinson’s disease and atypical Parkinsonian syndromes combining [11C]raclopride PET uptake and MRI grey matter morphometry". Journal of Neural Engineering (2021): https://doi.org/10.1088/1741-2552/abf772.
    10.1088/1741-2552/abf772
  28. Palma, Elisa; Raposinho, Paula; Cabral Campello, Maria Paula; Belo, Dulce; Guerreiro, Joana; Alves, Vitor; Fonseca, Alexandra; et al. "Anticancer Activity and Mode of Action of Copper (II)- Bisthiosemicarbazonato Complexes with Pendant Nitrogen Heterocycles". European Journal of Inorganic Chemistry (2021): http://dx.doi.org/10.1002/ejic.202100168.
    10.1002/ejic.202100168
  29. Diliana Rebelo; Francisco Oliveira; Antero Abrunhosa; Cristina Januário; João Lemos; Miguel Castelo-Branco. "A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease". Proceedings of the National Academy of Sciences (2021): https://doi.org/10.1073/pnas.2013962118.
    10.1073/pnas.2013962118
  30. Jorge L; Martins R; Canário N; Xavier C; Abrunhosa A; Santana I; Castelo-Branco M. "Investigating the Spatial Associations Between Amyloid-ß Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer's Disease.". Journal of Alzheimer's disease : JAD (2021): http://europepmc.org/abstract/med/33523050.
    10.3233/jad-200840
  31. Fonseca, Alexandra; Alves, Vitor; do Carmo, Sergio; Alves, Francisco; Abrunhosa, Antero. "Copper-61 from liquid targets: optimized purification for GMP labelling". Nuclear Medicine and Biology (2021): https://publons.com/wos-op/publon/53879081/.
  32. Gameiro, C.; Alves, V. H.; Abrunhosa, A.; Alves, F.; Goblet, D.; Nactergal, B.; Uhlending, A.; et al. "Securing Gallium-68 availability with liquid target production on mid-energy cyclotrons: Users' experience and scaling up". European Journal of Nuclear Medicine and Molecular Imaging (2021): https://publons.com/wos-op/publon/53879080/.
  33. Neves, Angela C. B.; Hrynchak, Ivanna; Fonseca, Ines; Alves, Vitor H. P.; Pereira, Mariette M.; Falcao, Amilcar; Abrunhosa, Antero J.. "Advances in the automated synthesis of 6-[F-18]Fluoro-L-DOPA (vol 6, 11, 2021)". EJNMMI Radiopharmacy and Chemistry (2021): https://publons.com/wos-op/publon/47467149/.
    10.1186/S41181-021-00132-1
  34. Chilug, Livia Elena; Nan, Alexandrina; Leonte, Radu Anton; Dusman, Ramona Daniela; Abrunhosa, Antero; Manda, Gina; Turcu, Rodica; Niculae, Dana. "Preclinical assessment of nanoparticles conjugated with Cu-64-DOTA-PEG-BBN targeting gastrin-releasing peptide receptors". Journal of Nuclear Medicine (2021): https://publons.com/wos-op/publon/50901273/.
  35. Lapo Pais, M.; Jorge, L.; Martins, R.; Canario, N.; Xavier, C.; Abrunhosa, A.; Santana, I.; Bernardes, R.; Castelo-Branco, M.. "Texture Quantification Parameters for Alzheimer's disease diagnosis measured by 11C-(R)-PK11195 PET images". European Journal of Nuclear Medicine and Molecular Imaging (2021): https://publons.com/wos-op/publon/53665983/.
  36. Pinho, S. L.; Sereno, J.; Abrunhosa, A. J.; Rocha, J.; Delville, M. H.; Carlos, L. D.; Geraldes, C. F. G. C.. "Trimodal Contrast Agents for MRI and Optical Imaging". European Journal of Clinical Investigation (2021): https://publons.com/wos-op/publon/53448370/.
  37. Sara Almeida; Liliana Santos; Amílcar Falcão; Célia Gomes; Antero Abrunhosa. "In Vivo Tracking of Extracellular Vesicles by Nuclear Imaging: Advances in Radiolabeling Strategies". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21249443.
    10.3390/ijms21249443
  38. Pinto CIG; Bucar S; Alves V; Fonseca A; Abrunhosa AJ; da Silva CL; Guerreiro JF; Mendes F. "Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer.". Frontiers in molecular biosciences (2020): http://europepmc.org/abstract/med/33335914.
    10.3389/fmolb.2020.609172
  39. Fonseca AI; Alves VH; do Carmo SJC; Falcão A; Abrunhosa AJ; Alves F. "GMP automated purification of copper-61 produced in cyclotron liquid targets: methodological aspects.". Current radiopharmaceuticals (2020): http://europepmc.org/abstract/med/33183218.
    10.2174/1874471013666201112141844
  40. Lopes, Carla; Castelhano, Joao; Margarida Fernandes Beatriz; Carolina Fernandes; Mário Laço; Cristina Januário; Abrunhosa, Antero J; Castelo-Branco, Miguel; Ana Cristina Carvalho Rego. "Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers". European Journal of Clinical Investigation 50 S1 (2020): http://dx.doi.org/10.1111/eci.13369.
  41. Beatriz Lapa; Ana Cristina Gonçalves; Joana Jorge; Raquel Alves; Ana Salomé Pires; Ana Margarida Abrantes; Margarida Coucelo; et al. "Acute myeloid leukemia sensitivity to metabolic inhibitors: glycolysis showed to be a better therapeutic target". Medical Oncology 37 8 (2020): https://doi.org/10.1007/s12032-020-01394-6.
    10.1007/s12032-020-01394-6
  42. Domingues C; João Ferreira M; Silva R; Oliveira-Santos M; Andreia Gomes; Chichorro N; de Lima JP; et al. "Aortic valve microcalcification and cardiovascular risk: an exploratory study using sodium fluoride in high cardiovascular risk patients.". The international journal of cardiovascular imaging (2020): http://europepmc.org/abstract/med/32342245.
    10.1007/s10554-020-01854-0
  43. Oliveira-Santos, Manuel; McMahon, Gearoid; Castelo-Branco, Miguel; Silva, Rodolfo; Gomes, Andreia; Chichorro, Nuno; Abrunhosa, Antero; et al. "Renal artery wall 18F-NaF activity and glomerular filtration rate". Nuclear Medicine Communications 41 2 (2020): 126-132. http://dx.doi.org/10.1097/mnm.0000000000001128.
    10.1097/mnm.0000000000001128
  44. Oliveira-Santos, M.; McMahon, G.; Castelo-Branco, M.; Silva, R.; Gomes, A.; Chichorro, N.; Abrunhosa, A.; et al. "Renal artery wall 18F-NaF activity and glomerular filtration rate: an exploratory analysis in a high cardiovascular risk population". Nuclear medicine communications 41 2 (2020): 126-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077936746&partnerID=MN8TOARS.
    10.1097/MNM.0000000000001128
  45. Khan, I.; Zahoor, R.; Numair, M.; Shahid, A.; Abrunhosa, A. J.. "Copper-64 based Radiopharmaceuticals as Potential Theranostic Agents". European Journal of Nuclear Medicine and Molecular Imaging (2020): https://publons.com/wos-op/publon/53879086/.
  46. Joao Borges-Rosa, J.; Oliveira-Santos, M.; Silva, R.; Abrunhosa, A. J.; Castelo-Branco, M.; Goncalves, L.; Ferreira, M. J.. "Does global molecular calcium score have a role in HFpEF evaluation?". European Journal of Heart Failure (2020): https://publons.com/wos-op/publon/52988023/.
  47. Lopes, C.; Castelhano, J.; Beatriz, M.; Fernandes, C.; Laco, M.; Januario, C.; Abrunhosa, A.; Castelo-Branco, M.; Rego, A. R.. "Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers". European Journal of Clinical Investigation (2020): https://publons.com/wos-op/publon/52315933/.
  48. Bousquet J; Illario M; Farrell J; Batey N; Carriazo AM; Malva J; Hajjam J; et al. "The Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing.". Translational medicine @ UniSa (2019): http://europepmc.org/abstract/med/31360670.
  49. Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". Nanoscale 11 28 (2019): 13243-13248. https://doi.org/10.1039/C9NR02512J.
    10.1039/C9NR02512J
  50. Pinho, S.L.C.; Sereno, J.; Abrunhosa, A.J.; Delville, M.-H.; Rocha, J.; Carlos, L.D.; Geraldes, C.F.G.C.. "Gd- A nd Eu-Loaded Iron Oxide@Silica Core-Shell Nanocomposites as Trimodal Contrast Agents for Magnetic Resonance Imaging and Optical Imaging". Inorganic Chemistry 58 24 (2019): 16618-16628. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076411572&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.9b02655
  51. Chiquita, S.; Ribeiro, M.; Castelhano, J.; Oliveira, F.; Sereno, J.; Batista, M.; Abrunhosa, A.; et al. "A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss". Human Molecular Genetics 28 13 (2019): 2174-2188. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068494943&partnerID=MN8TOARS.
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  52. Banerjee, A.; Alves, V.; Rondão, T.; Sereno, J.; Neves, Â.; Lino, M.; Ribeiro, A.; Abrunhosa, A.J.; Ferreira, L.S.. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track: In vivo small extracellular vesicles". Nanoscale 11 28 (2019): 13243-13248. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069194725&partnerID=MN8TOARS.
    10.1039/c9nr02512j
  53. Banerjee, Arnab; Alves, Vitor; Rondão, Tiago; Sereno, José; Neves, Ângela; Lino, Miguel; Ribeiro, Andreia; Abrunhosa, Antero; Ferreira, Lino. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". (2019): http://hdl.handle.net/10316/87318.
  54. Domingues, C.; Oliveira-Santos, M.; Castelo-Branco, M.; Silva, R.; Gomes, A.; Chichorro, N.; Abrunhosa, A.; et al. "Cardiovascular risk, aortic valve microcalcification and vascular microcalcification: is there a link?". European Heart Journal (2019): https://publons.com/wos-op/publon/33346986/.
  55. Banerjee, Arnab; Rondao, Tiago; Sereno, Jose; Alves, Vitor; Lino, Miguel; Ribeiro, Andreia; Abrunhosa, Antero; Ferreira, Lino. "PET imaging and in vivo bio-distribution of small extracellular vesicles". European Journal of Clinical Investigation (2019): https://publons.com/wos-op/publon/53879095/.
  56. Niculae, D.; Chilug, L. E.; Serban, R. M.; Abrunhosa, A. J.; Leonte, R. A.; Turcu, R.; Nan, A.; Lavric, V.. "Activated Gold Nanoparticles Conjugated with 68Ga-DOTA-PEG(4)-BBN(7-14) for Targeting Tumours Expressing GRP Receptors". European Journal of Nuclear Medicine and Molecular Imaging (2019): https://publons.com/wos-op/publon/27831977/.
  57. Bousquet, J.; Illario, M.; Farrell, J.; Batey, N.; Carriazo, A. M.; Malva, J.; Hajjam, J.; et al. "THE REFERENCE SITE COLLABORATIVE NETWORK OF THE EUROPEAN INNOVATION PARTNERSHIP ON ACTIVE AND HEALTHY AGEING". Translational Medicine @ UniSa (2019): https://publons.com/wos-op/publon/21269344/.
  58. Carlos F. D. Rodrigues; Eurico Serrano; Maria I. Patrício; Mariana M. Val; Patrícia Albuquerque; João Fonseca; Célia M. F. Gomes; et al. "Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-29947-w.
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  59. Joana F Guerreiro; Vítor Alves; Antero Abrunhosa; António Paulo; Octávia Monteiro Gil; F Mendes. "Radiobiological Characterization of 64CuCl2 as a Simple Tool for Prostate Cancer Theranostics". Molecules (2018): http://www.mdpi.com/1420-3049/23/11/2944.
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  60. Vítor Alves; Sergio JC do Carmo; Francisco José Cerqueira Alves; Antero Abrunhosa. "Automated Purification of Radiometals Produced by Liquid Targets". Instruments (2018): http://www.mdpi.com/2410-390X/2/3/17.
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  61. Daniela I. Paiva-Oliveira; Sara R. Martins-Neves; Antero J. Abrunhosa; Carlos Fontes-Ribeiro; Célia M. F. Gomes. "Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells". Cancer Chemotherapy and Pharmacology (2018): https://doi.org/10.1007/s00280-017-3467-6.
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  62. Oliveira, F.; Leuzy, A.; Castelhano, J.; Chiotis, K.; Hasselbalch, S.G.; Rinne, J.; Mendonça, A.; et al. "Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aß species". NeuroImage: Clinical 20 (2018): 603-610. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052649302&partnerID=MN8TOARS.
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  65. Gois, L.; Ferreira, N.; Abrunhosa, A.; Moreira, A.; Oliveira, F.; Patricio, M.; Caramelo, F.. "qPET: a system for assessing the arterial input function for PET quantification". European Journal of Nuclear Medicine and Molecular Imaging (2018): https://publons.com/wos-op/publon/29668912/.
  66. Bertrand, S.; Geets, J.; Kral, E.; Gameiro, C.; Nactergal, B.; Devillet, F.; Alves, F.; et al. "Optimized non-conventional radioisotopes production with industrial mid-energy cyclotron". European Journal of Nuclear Medicine and Molecular Imaging (2018): https://publons.com/wos-op/publon/53879096/.
  67. Abrunhosa, Antero. "Deconstructing cancer stem cells: IL-6, G-CSF and Activin-A as mediators of stroma-orchestrated epithelial cells’ dedifferentiation". Cancer Research 77 13 Supplem (2017): 1915-1915. https://doi.org/10.1158%2F1538-7445.am2017-1915.
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  68. Abrunhosa, Antero. "Production of copper-64 and gallium-68 with a medical cyclotron using liquid targets". Modern Physics Letters A (2017):
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  69. Oliveira-Santos M; Castelo-Branco M; Silva R; Gomes A; Chichorro N; Abrunhosa A; Donato P; et al. "Atherosclerotic plaque metabolism in high cardiovascular risk subjects - A subclinical atherosclerosis imaging study with 18F-NaF PET-CT.". (2017): http://europepmc.org/abstract/med/28349887.
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  71. Ferreira MJ; Oliveira-Santos M; Silva R; Gomes A; Ferreira N; Abrunhosa A; Lima J; et al. "Assessment of atherosclerotic plaque calcification using F18-NaF PET-CT.". (2017): http://europepmc.org/abstract/med/28070735.
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  72. Do Carmo, S.J.C.; Alves, V.H.P.; Alves, F.; Abrunhosa, A.J.. "Fast and cost-effective cyclotron production of61Cu using anatZn liquid target: An opportunity for radiopharmaceutical production and R&D". Dalton Transactions 46 42 (2017): 14556-14560. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032646302&partnerID=MN8TOARS.
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  73. Alves, F.; Alves, V.H.P.; Do Carmo, S.J.C.; Neves, A.C.B.; Silva, M.; Abrunhosa, A.J.. "Production of copper-64 and gallium-68 with a medical cyclotron using liquid targets". Modern Physics Letters A 32 17 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019686668&partnerID=MN8TOARS.
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  74. Gonçalves, J.; Violante, I.R.; Sereno, J.; Leitão, R.A.; Cai, Y.; Abrunhosa, A.; Silva, A.P.; Silva, A.J.; Castelo-Branco, M.. "Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: In vivo neurospectroscopy and molecular evidence for regional phenotypes". Molecular Autism 8 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85029603049&partnerID=MN8TOARS.
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  76. Alves, Francisco; Alves, Vitor; Neves, Angela; Abrunhosa, Antero. "GMP Production of Gallium-68 from a Cyclotron Using Liquid Targets: Regulatory Aspects". Journal of Labelled Compounds (2017): https://publons.com/wos-op/publon/53879097/.
  77. Antero J Abrunhosa; Vitor Hugo Alves; Angela Neves; Carmo Sergio JC do; Benoit Nactergal; Vincent Hellas; Erik Kral; Cristiana Gameiro-Paris; Francisco Alves. "Production of 68Ga in a mid-energy cyclotron: the solution is in the target". Endocrine Abstracts (2016): https://doi.org/10.1530%2Fendoabs.47.oc49.
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  78. Violante IR; Patricio M; Bernardino I; Rebola J; Abrunhosa AJ; Ferreira N; Castelo-Branco M. "GABA deficiency in NF1: A multimodal [11C]-flumazenil and spectroscopy study.". (2016): http://europepmc.org/abstract/med/27473134.
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  80. Martins-Neves SR; Paiva-Oliveira DI; Wijers-Koster PM; Abrunhosa AJ; Fontes-Ribeiro C; Bovée JV; Cleton-Jansen AM; Gomes CM. "Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/ß-catenin signaling.". (2016): http://europepmc.org/abstract/med/26577806.
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  81. Violante, I.R.; Patricio, M.; Bernardino, I.; Rebola, J.; Abrunhosa, A.J.; Ferreira, N.; Castelo-Branco, M.. "GABA deficiency in NF1". Neurology 87 9 (2016): 897-904. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984801008&partnerID=MN8TOARS.
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  82. Silva, R.; Abrunhosa, A.; Figueiredo, A.; Cruz, A.; Xavier, A.; Barroca, D.; Castelo Branco, M.; Pedroso de Lima, J.. "68Ga-PSMA PET/CT in Biochemical Relapsed Prostate Cancer Initial Experience". European Journal of Nuclear Medicine and Molecular Imaging (2016): https://publons.com/wos-op/publon/17779119/.
  83. Nuno P. F. Gonçalves; Ana V. C. Simões; Artur R. Abreu; Antero J. Abrunhosa; Janusz M. Dabrowski; Mariette M. Pereira. "Synthesis and biological distribution study of a new carbon-11 labeled porphyrin for PET imaging. Photochemical and biological characterization of the non-labeled porphyrin". Journal of Porphyrins and Phthalocyanines 19 08 (2015): 946-955. https://doi.org/10.1142%2Fs1088424615500728.
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  85. Goreti Ribeiro Morais; Elisa Palma; Fernanda Marques; Lurdes Gano; Maria Cristina Oliveira; Antero Abrunhosa; Hugo Vicente Miranda; et al. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry 54 1 (2015): 255-267. https://doi.org/10.1002%2Fjhet.2575.
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  88. Alves, V.H.; Prata, M.I.M.; Abrunhosa, A.J.; Castelo-Branco, M.. "GMP production of 68Ga-labelled DOTA-NOC on IBA Synthera". Journal of Radioanalytical and Nuclear Chemistry 305 2 (2015): 501-506. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937977799&partnerID=MN8TOARS.
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  90. Ribeiro Morais G; Gano L; Kniess T; Bergmann R; Abrunhosa A; Santos I; Paulo A. "Radiosynthesis and in vivo evaluation of a ¹8F-labelled styryl-benzoxazole derivative for ß-amyloid targeting.". (2013): http://europepmc.org/abstract/med/23974304.
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  91. Simoes, Ana; Calvete, Mario; Pereira, Mariette; Llop, Jorid; Gomez-Vallejo, Vanessa; Abrunhosa, Antero J.. "Radiosynthesis of new F-18-labelled meso-tetraphenylporphyrins as potential tracers for in vivo molecular imaging with PET". Journal of Labelled Compounds and Radiopharmaceuticals (2013): https://publons.com/wos-op/publon/433393/.
  92. Alves, Vitor H.; Prata, Maria, I; Abrunhosa, Antero J.; Castelo-Branco, Miguel. "Automated 68Ga-DOTA-NOC production using a commercial synthesizer". Journal of Labelled Compounds and Radiopharmaceuticals (2013): https://publons.com/wos-op/publon/4072464/.
  93. C.F.D. Rodrigues; C.M.F. Gomes; A. Abrunhosa; M. Alves; A.M. Ribeiro; C. Monteiro; A. Paiva; I.M. Carreira; M.C. Alpoim. "473 Hexavalent Chromium, Cancer Stem Cells and Dedifferentiation –a View to a Kill!". European Journal of Cancer 48 (2012): S114-S114. https://doi.org/10.1016%2Fs0959-8049%2812%2971146-2.
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  94. Martins-Neves SR; Lopes ÁO; do Carmo A; Paiva AA; Simões PC; Abrunhosa AJ; Gomes CM. "Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line.". (2012): http://europepmc.org/abstract/med/22475227.
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  95. Fernandes, E.; Barbosa, Z.; Clemente, G.; Alves, F.; Abrunhosa, A.J.. "Positron emitting tracers in pre-clinical drug development". Current Radiopharmaceuticals 5 2 (2012): 90-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857135421&partnerID=MN8TOARS.
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  96. Abrunhosa, Antero; Alves, Francisco; Oxley, Ian; Boumon, Rony; Gameiro, Cristiana. "Optimization of [18F]-FDG production with terminal sterilization by autoclave". Journal of Nuclear Medicine (2012): https://publons.com/wos-op/publon/53879100/.
  97. Gomes CM; Abrunhosa AJ; Ramos P; Pauwels EK. "Molecular imaging with SPECT as a tool for drug development.". (2011): http://europepmc.org/abstract/med/20933557.
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  98. Gomes, C.M.F.; Abrunhosa, A.J.; Pauwels, E.K.J.. "Molecular imaging with SPECT and PET in exploratory investigational new drug studies". Drugs of the Future 36 1 (2011): 69-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955995627&partnerID=MN8TOARS.
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  100. Botelho MF; Marques MA; Gomes C; da Silva AM; Bairos V; Santos Rosa MA; Abrunhosa AP; de Lima JJ. "Nanoradioliposomes molecularly modulated to study the lung deep lymphatics drainage.". (2010): http://europepmc.org/abstract/med/25965698.
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  101. Neves SR; Lopes AO; do Carmo A; Abrunhosa AJ; Simões PC; Paiva AA; Botelho MF; Gomes CM. "Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapy.". (2010): http://europepmc.org/abstract/PMC/PMC3255038.
  102. Gomes, C. M. F.; Neves, S. R. M.; Lopes, A. O. G.; do Carmo, A.; Abrunhosa, A. J.; Botelho, M.. "Assessing metabolic activity of cancer stem cells during differentiation with [F-18]FDG". European Journal of Nuclear Medicine and Molecular Imaging (2010): https://publons.com/wos-op/publon/6366036/.
  103. Neves, S. R. M.; Lopes, A. O. G.; Abrunhosa, A. J.; Simoes, P. C. P. S.; Paiva, A. A.; Botelho, M.; Gomes, C. M. F.. "Cancer stem cell populations in osteosarcoma: implications for [18F]FDG uptake and response to therapy". European Journal of Nuclear Medicine and Molecular Imaging (2010): https://publons.com/wos-op/publon/6366017/.
  104. Gomes CM; Abrunhosa AJ; Pauwels EK; Botelho MF. "P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin.". (2009): http://europepmc.org/abstract/med/19409044.
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  105. Maria Filomena Rabaça Roque Botelho; Maria Alcide Tavares Marques; Célia Maria Freitas Gomes; Augusto Marques Ferreira da Silva; Vasco António Andrade Figueiredo Bairos; Manuel Amaro de Matos Santos Rosa; Antero Pena Abrunhosa; João José Pedroso de Lima. "Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda". Revista Portuguesa de Pneumologia 15 2 (2009): 261-293. https://doi.org/10.1016%2Fs0873-2159%2815%2930131-8.
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  106. Botelho, M.F.R.R.; Marques, M.A.T.; Gomes, C.M.F.; da Silva, A.M.F.; Bairos, V.A.A.F.; Rosa, M.A. de M.S.; Abrunhosa, A.P.; de Lima, J.J.P.. "Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage | Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda". Revista Portuguesa de Pneumologia 15 2 (2009): 261-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650327279&partnerID=MN8TOARS.
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  107. Botelho,Maria Filomena Rabaça Roque; Marques,Maria Alcide Tavares; Gomes,Célia Maria Freitas; Silva,Augusto Marques Ferreira da; Bairos,Vasco António Andrade Figueiredo; Rosa,Manuel Amaro de Matos Santos; Abrunhosa,Antero Pena; Lima,João José Pedroso de. "Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage". (2009): http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0873-21592009000200009.
  108. Gomes CM; Welling M; Que I; Henriquez NV; van der Pluijm G; Romeo S; Abrunhosa AJ; et al. "Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi.". (2007): http://europepmc.org/abstract/med/17541583.
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  110. Gomes, C. M. F.; Abrunhosa, A. J.; Pauwels, E. K. J.; Botelho, M. F.. "[Tc-99m]Sestamibi vs. [Tc-99m]Tetrofosmin for functional assessment of P-glycoprotein and MRP1-mediated drug resistance in SCLC cell lines". European Journal of Nuclear Medicine and Molecular Imaging (2007): https://publons.com/wos-op/publon/6365952/.
  111. Gomes, C. M. F.; Welling, M.; Que, I.; Henriquez, N. V.; van der Pluijm, G.; Romeo, S.; Abrunhosa, A. J.; et al. "Molecular imaging of multidrug resistance in an orthotopic model of osteosarcoma". Laboratory Investigation (2007): https://publons.com/wos-op/publon/22826540/.
  112. Gomes CM; van Paassen H; Romeo S; Welling MM; Feitsma RI; Abrunhosa AJ; Botelho MF; et al. "Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies.". (2006): http://europepmc.org/abstract/med/17045162.
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  113. Gomes, CM; Van Paassen, HJ; Welling, MM; Feitsma, RJ; Abrunhosa, AJ; Botelho, MF; Hogendoorn, PC; Pauwels, EK; Cleton-Jansen, AM. "Multidrug resistance activity in human osteosarcoma cell lines and reversal of chemosensitivity". Modern Pathology (2006): https://publons.com/wos-op/publon/26303367/.
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  121. Santos, RM; Barbosa, RM; Antunes, CM; Silva, AM; Salgado, AP; Abrunhosa, AJ; Pereira, FC; Seica, RM; Rosario, LM. "Bursting electrical activity generated in the presence of K-ATP channel blockers". Advances in Experimental Medicine and Biology (1997): https://publons.com/wos-op/publon/12554458/.
    10.1007/978-1-4899-1819-2_5
  122. Rosário, L.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A.M.; Abrunhosa, A.J.; Santos, R.M.. "Bursting electrical activity in pancreatic ß-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels". Pflügers Archiv European Journal of Physiology 424 5-6 (1993): 439-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027282069&partnerID=MN8TOARS.
    10.1007/BF00374906
Preprint
  1. Luís Leite; Tomás Carlos; Gustavo Campos; Helena Donato; Rodolfo Silva; Antero Abrunhosa; Lino Gonçalves; Maria João Ferreira. "Effects of successful percutaneous coronary intervention of chronic total occlusions with demonstrable viability or ischemia: A protocol for a systematic review". 2023. https://doi.org/10.1101/2023.08.01.23293494.
    10.1101/2023.08.01.23293494
  2. Alexandra I. Fonseca; Vitor H. Alves; Ivanna Hrynchak; Francisco Alves; Antero J. Abrunhosa. "Fully Automated Production of [68Ga]FAPI-46 with Gallium-68 from Cyclotron Using Liquid Targets". 2023. https://doi.org/10.20944/preprints202309.0931.v1.
    10.20944/preprints202309.0931.v1
Thesis / Dissertation
  1. Rodrigues, Iolanda Beatriz Albuquerque. "Synthesis Optimisation of High Specific Activity Carbon-11 Radiopharmaceuticals for Brain PET Studies". Master, 2020. http://hdl.handle.net/10316/90183.
  2. Fonseca, Alexandra Isabel Simões. "Labelling and validation of [61Cu]DOTA-NOC for somatostatin receptors imaging". Master, 2019. http://hdl.handle.net/10316/87934.
  3. Cruz, Ângela Cristina Simões. "Investigação de um detetor não-invasivo para determinar a função de entrada em estudos PET quantitativos". Master, 2018. http://hdl.handle.net/10400.26/23180.
  4. Catarino, Ana Rita. "Selective internal radiation therapy: review of the standard operating procedure for selective internal radiation therapy using SIR-Spheres microspheres labelled with Yttrium 90". Master, 2017. http://hdl.handle.net/10400.26/22708.
  5. Vintém, João Paulo Nogueira, 1991-. "Desenvolvimento de um modelo dosimétrico baseado em medidas de área". Master, 2015. http://hdl.handle.net/10400.26/14512.
  6. Simões, Ana Vanessa Cordeiro. "Síntese de macrociclos tetrapirrólicos fluorados. Desenvolvimento de potenciais marcadores para tomografia por emissão de positrões". PhD, 2014. http://hdl.handle.net/10316/25271.
  7. Barroca, Dalila. "Estudo combinado de PET com [11C]PiB e [18F]FDG na avaliação de doença de Alzheimer". Master, 2014. http://hdl.handle.net/10400.26/14488.
  8. Serra, Cristina. "Optimização e Validação da Produção de [13n]-Nh3 para Estudos Clínicos de Tomografia por Emissão de Positrões na Avaliação da Perfusão Miocárdica". Master, 2014. http://hdl.handle.net/10400.22/5725.
  9. Rio, Joana Maria Teixeira Espinheira. "Importância da [11C]-Racloprida no diagnóstico de Síndromes Parkinsónicos com tomografia por emissão de positrões (PET)". Master, 2014. http://hdl.handle.net/10400.26/17038.
  10. Clemente, Gonçalo dos Santos. "Synthesis of optimization of [11C] Pittsburgh compound B by the captive solvent method". Master, 2013. http://hdl.handle.net/10400.21/2314.
  11. Moreira, Hugo Manuel Ramos. "Cyclotron Production of 68Ga using a 68Zn-based liquid target". Master, 2013. http://hdl.handle.net/10316/32456.
  12. Alves, Vítor Hugo Pereira. "Optimisation of synthesis, purification and reformulation of (R)-[N-methyl-¹¹C] PK11195 for in vivo PET imaging studies". Master, 2012. http://hdl.handle.net/10316/26005.
  13. Abrunhosa, Antero José Pena Afonso de. "Métodos computacionais no desenvolvimento de radiofármacos para a tomografia por emissão de positrões.". PhD, 2002. http://hdl.handle.net/10316/810.

Intellectual property

Patent
  1. Caramelo, Francisco; Oliveira, Francisco PM; Pereira, Carlos; Ferreira, Nuno; Dias, Miguel; Cruz, Angela; Abrunhosa, Antero; Moreira, Ana Paula. 2021. "NON-INVASIVE SYSTEM FOR MEASURING THE ARTERIAL INPUT FUNCTION FOR PET IMAGING". Portugal.
    Granted/Issued

Other

Other output
  1. Prototype of an affordable pressure-controlled emergency mechanical ventilator for COVID-19. 2020. Pereira A; Lopes L; Fonte P; Póvoa P; Santos TG; Martinho A; Neves Â; et al. http://europepmc.org/abstract/PPR/PPR270077.
  2. Synthesis of (R)-[N-Methyl-11C]PK11195. 2015. Vítor H. Alves; Antero J. Abrunhosa; Miguel Castelo-Branco. https://doi.org/10.1002%2F9781118834114.ch10.
    10.1002/9781118834114.ch10
  3. Preliminary Studies of Computer Aided Ligand Design for PET. 2001. A.J. Abrunhosa; F. Brady; S. Luthra; J.J. De Lima; T. Jones. https://doi.org/10.1016%2Fb978-012285751-5%2F50011-9.
    10.1016/b978-012285751-5/50011-9
  4. Use of Information Technology in the Search for New PET Tracers. 1998. A.J. Abrunhosa; F. Brady; S.K. Luthra; H. Morris; J.J. De Lima; T. Jones. https://doi.org/10.1016%2Fb978-012161340-2%2F50042-1.
    10.1016/b978-012161340-2/50042-1
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023 - Current Efficacy and Safety of 225Ac-DOTA-SP as Adjuvant Therapy in Recurrent Glioblastoma Multiforme: A Pilot Study
Supervisor of Carla Margarida Alves Domingos
Universidade de Coimbra Faculdade de Medicina, Portugal
2022 - Current PET/CT imaging biomarkers in the tumor microenvironment of patients with penile cancer
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2022 - Current Targeting brain amyloid-ß oligomers with positron emission tomography in early diagnosis of Alzheimer's disease: preclinical validation and first-in-human studies.
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2021 - Current ImmunoPET imaging to help predict response to first line pembrolizumab in NSCLC patients with PD-L1>=50%
Supervisor of Sónia Gonçalves Silva
Universidade de Coimbra Faculdade de Medicina, Portugal
2021 - Current Tumor-derived Exosomes as Nanotheranostic Tools for Lung Metastasis Detection and Treatment
Supervisor of Diana Margarida de Almeida Rodrigues
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - Current Novel Metal Radiopharmaceuticals for Theranostics in Oncology and Neuroscience
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - 2024 Unravel the role of HER2 in breast cancer brain metastasis: a pre-clinical approach using anti-HER2 radiolabeled nanobodies
Supervisor of Liliana Pereira Santos
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - 2024 Development and validation of a new generation of copper-based radiopharmaceuticals
Supervisor of Alexandra Isabel Simões Fonseca
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2024 Development of a PET Probe for the Neuropeptide Y2 Receptors
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2023 Role of osteosarcoma-derived secretome and exosomes in lung-metastatic organotropism: from premetastatic niche formation to molecular imaging
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - 2022 Advanced microwave technology in radiopharmaceutical synthesis
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - 2020 Synthesis Optimisation of High Specific Activity Carbon-11 Radiopharmaceuticals for Brain PET Studies
Supervisor
Engenharia Biomédica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2020 New morphometric biomarkers of the cerebellum by magnetic resonance: validation in Machado-Joseph disease
Co-supervisor
Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2020 Production and purification of radiometals for theranostics via liquid targets in a medical cyclotron
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Labelling and validation of [61Cu]DOTA-NOC for somatostatin receptors imaging
Supervisor
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2014 Síntese de Macrociclos Tetrapirrólicos Fluorados. Desenvolvimento de Potenciais Marcadores para Tomografia por Emissão de Positrões
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Distinctions

Other distinction

2008 Robalo Cordeiro Award
Sociedade Portuguesa de Pneumologia, Portugal
1999 Young Investigator Award
Society of Nuclear Medicine and Molecular Imaging, United States
1997 Honourable mention of the Scientific Committee
Society of Nuclear Medicine and Molecular Imaging, United States