Ana Rita da Costa Pinto (1313-66B7-2A1E)

Curriculum Vitae

Ana Rita da Costa Pinto

I am a multidisciplinary scientist with over 16 years of research experience in the academic environment. I graduated in Applied Biology in 2003 and obtained my PhD in Tissue Engineering, Regenerative Medicine and Stem Cells (at I3Bs) in 2011, both from the University of Minho. Furthermore, I developed part of my PhD research at the Universitá La Sapienza in Rome in the Stem Cells Lab under the supervision of Prof. Paolo Bianco and at the University of Beytepe in Ankara. My PhD work was focused on the development of a functional bone tissue engineering approach using chitosan derived biomaterials and human bone marrow stromal cells. From 2011 to 2016 I developed post-doc research at the I3Bs group, working with fetal stem cells and novel methodologies to biofunctionalize biomaterials. I also worked with nanoparticles for applications in biomedicine and 3D models for tumor microenvironment. During that period, I was awarded an intramural project as PI and another as Co-PI. At the end of 2016, I joined the Portuguese Catholic University research team to perform post-doc research with chitosan and codfish derived hydroxyapatite formulations to circumvent periprosthetic joint infections, with a patent submission ongoing. I am the author/co-author of 29 articles and 3 book chapters, with a h-index of 15 and to date with more than 1200 citations. I participated in several research projects as a team member and as a researcher and was involved in the organization of scientific conferences. I am an invited expert reviewer for European Commission, WHRI-ACADEMY, German Israeli Foundation for Scientific Research and Development, Romanian Executive Agency for Higher Education, Research, Development, and Innovation, and Consultancy Services for Project Peer Review of the Science Fund of the Republic of Serbia, as well as for several international journals. I also possess major experience in writing grants for FP7, and Horizon 2020, as well as for FCT. Currently, I am a Researcher at the Genetic Dynamics of Cancer Cells Group at i3S/IPATIMUP. My main research interests are the study of the biodistribution of pancreatic cancer exosomes during disease progression and to understand how impairing these communication routes may hamper tumor growth, metastasis, and improve therapy response.

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Identification

Personal identification

Full name: Ana Rita da Costa Pinto
Date of birth: 1980/12/22
Gender: Female

Citation names

Costa-Pinto, Ana Rita

Author identifiers

Ciência ID: 1313-66B7-2A1E
ORCID iD: 0000-0002-4764-8539
Google Scholar ID: zrkz17kAAAAJ&hl
Researcher Id: I-7483-2013
Scopus Author Id: 24390737500

Email addresses

anap@ipatimup.pt (Professional)
a.r.cpinto@gmail.com (Personal)

Telephones

Telephone

220408800 Ext.: 6178 (Professional)

Addresses

Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Porto, Portugal (Professional)

Websites

https://www.i3s.up.pt/content/people?id=2755&idg=22 (Scholar)
https://www.linkedin.com/in/ana-rita-costa-pinto-65866333/ (Professional)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Biomaterials
Medical and Health Sciences - Clinical Medicine - Oncology
Engineering and Technology - Nano-technology - Nano-materials
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Italian	Elementary (A2)	Beginner (A1)	Beginner (A1)	Elementary (A2)	Beginner (A1)
Spanish; Castilian	Elementary (A2)	Intermediate (B1)	Elementary (A2)	Intermediate (B1)	Beginner (A1)
French	Beginner (A1)	Elementary (A2)	Beginner (A1)	Elementary (A2)	Beginner (A1)

Education

	Degree	Classification
2015 - 2015 Attended	I Course on Advanced Widefield and Confocal Microscopy and STED Super-Resolution (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2006 - 2011 Concluded	Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento) Universidade do Minho, Portugal "Potential of human bone marrow derived stem cells combined with chitosan based biodegradable scaffolds for bone tissue engineering" (THESIS/DISSERTATION)	Aprovada
2008 - 2008 Attended	FEBS advanced course “QCM, SPR/elipsometer & AMF as novel Biosensors & Imaging Systems" (Postgraduate Certificate) Hacettepe Üniversitesi, Turkey
2006 - 2006 Attended	Course on Laboratory Animal Science”, level C FELASA (Pós-Graduação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2005 Attended	12th Cirmib Biomaterials School and 1st Expertissues: From Biomedical Devices to Molecular Recognition and Tissue Engineered Products (Outros) Università degli Studi di Trento, Italy
2004 - 2004 Attended	Microarrays: Principles and Applications in Medicine (Outros) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
1998 - 2003 Concluded	Biologia Aplicada (Licenciatura) Universidade do Minho, Portugal "Study of the gene DHCR7" (THESIS/DISSERTATION)	15

Affiliation

Science

	Category Host institution	Employer
2019/03/18 - Current	Contracted Researcher (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2016/11/01 - 2019/03/17	Postdoc (Research)	Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

2013/03 - 2016/10	Postdoc (Research)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Minho, Portugal
2011/07 - 2013/02	Postdoc (Research)	Biomaterials Biodegradables and Biomimetics, Portugal
	Universidade do Minho, Portugal
2006 - 2011	Researcher (Research)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Minho, Portugal
2004/11 - 2005/12	Researcher (Research)	Biomaterials Biodegradables and Biomimetics, Portugal
	Universidade do Minho, Portugal
2004/01 - 2004/10	Researcher (Research)	Universidade do Minho Centro de Engenharia Biológica, Portugal
	Universidade do Minho, Portugal

Projects

Grant

	Designation	Funders
2016 - 2019	Bioengineered Therapies for Infectious Diseases and Tissue Regeneration NORTE-01-0145-FEDER-000012 Post-doc Fellow Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Ongoing
2016 - 2017	STEM4CDH – Fetal Stem Cells as Therapeutic Strategy for Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia ICVS/3Bs Associated Lab Grants 2016 Supervisor Biomaterials Biodegradables and Biomimetics, Portugal	Concluded
2014 - 2015	ARTHYMUS - Artificial thymus conception: a tissue engineering strategy. ICVS/3Bs Associated Lab Grants 2014 Supervisor	Concluded
2014 - 2015	3DTumours - Development of a 3D culture system for the in vitro study of tumor pathophysiology. ICVS/3Bs Associated Lab Grants 2014 Researcher	Concluded
2011 - 2012	3D patterned co-culture system to develop vascularized engineered bone PTDC/EME-MFE/108892/2008 Post-doc Fellow Biomaterials Biodegradables and Biomimetics, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2004 - 2005	Adult Mesenchymal Stem Cells Engineering for Connective Tissue Disorders. From the Bench to the Bed Side LSHB-CT-2007-033168 Research Fellow Biomaterials Biodegradables and Biomimetics, Portugal	European Commission Seventh Framework Programme for Research and Technological Development Research Potential of Convergence Regions Concluded

Contract

	Designation	Funders
2019/03 - Current	Terapias Dirigidas a Rede de Comunicação Mediada por Exossomas em Cancro Pancreático POCI-01-0145-FEDER-032189 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2013 - 2015	Maxillofacial Reconstruction using regenerative therapies: from Stem Cells to pre-Clinical Trials PTDC/SAU-ENB/115179/2009 Post-doc Fellow Biomaterials Biodegradables and Biomimetics, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2011	Mastering sweet cell-instructive biosystems by copycat nano-interaction of cells with natural surfaces for biotechnological applications NMP4-SL-2009-229292 Post-doc Fellow Biomaterials Biodegradables and Biomimetics, Portugal	European Commission Seventh Framework Programme for Research and Technological Development Environment Concluded

Outputs

Publications

Book chapter	Alves Da Silva, Marta L.; Martins, Albino; Costa-Pinto, Ana; Reis, Rui L.; Neves, Nuno M.. "In Vitro Biological Testing in the Development of New Devices". In Biomaterials from Nature for Advanced Devices and Therapies, 532-550. John Wiley & Sons, Inc., 2016. 10.1002/9781119126218.ch28 Costa-Pinto, Ana; Santos, T. C.; Neves, N. M.; Reis, R. L.; Pinto, Ana. "Testing natural biomaterials in animal models". Portugal: John Wiley & Sons, 2016. 10.1002/9781119126218.ch30 Martins, Albino; da Silva, Marta Alves; Costa-Pinto, Ana; Reis, Rui L.; Neves, Nuno M.. "Bio-Inspired Integration of Natural Materials". In Bio-inspired Materials for Biomedical Engineering, 125-150. John Wiley & Sons, Inc., 2014. 10.1002/9781118843499.ch8
Conference paper	Rodrigues, Dina; Pinto, Ana Rita; Amorim, Maria; Rocha-Santos, Teresa; Costa, João; Silva, Artur; Duarte, Armando; Gomes, Ana Maria; Freitas, Ana Cristina. "Structural and cytotoxic characterization of sargassum muticum and osmundea pinnatifida enzymatic extraxts with biological properties". 2017. Costa-Pinto, Ana R.; Lemos, Ana L.; Piccirillo, Clara; Tavaria, Freni K; Pintado, Manuela E.. "Chitosan and codfish hydroxyapatite formulation to be used as coating material to circumvent periprosthetic joint infections". 2017. Pinto, Ana. "Biological performance of human bone marrow mesenchymal stem cells cultured onto novel chitosan polyester scaffolds". 2012. 10.1002/term.1608
Conference poster	Costa-Pinto, Ana Rita. "Safety assessment of Baby bibs as food contact materials by QSAR approach and in vitro cytotoxicity assay". Paper presented in MATBIM2019, 2019. Costa-Pinto, Ana Rita. "Production of chitosan and codfish derived hydroxyapatite formulations to circumvent prosthetic joint infections". Paper presented in Encontro Ciência 2018, 2018. Costa-Pinto, Ana Rita. "Development of chitosan and codfish hydroxyapatite pastes to evade prosthetic joint infections". Paper presented in MISSION 10.000 Conference, 2018. Costa-Pinto, Ana Rita. "In-situ forming silk sericin-based hydrogel for chronic wound healing". Paper presented in CESB 2017 - 6th China-Europe Symposium on Biomaterials in Regenerative Medicine, 2017. Costa-Pinto, Ana Rita. "Ultrasound Sonication Effects on Electrospun Silk-based Membranes for Periodontal Regeneration". Paper presented in CESB 2017 - 6th China-Europe Symposium on Biomaterials in Regenerative Medicine, 2017. Costa-Pinto, Ana Rita. "Human amniotic membrane stem cells isolation and characterization". Paper presented in Term Stem 2017, 2017. Costa-Pinto, Ana Rita. "Sardine roe: a potential source of lipids for biomedical applications". Paper presented in Term Stem 2017, 2017. Costa-Pinto, Ana Rita. "Development of chitosan and codfish hydroxyapatite formulations to circumvent prosthetic joint infections". Paper presented in ISBMS, 2017. Costa-Pinto, Ana Rita. "Structural and cytotoxic characterization of Sargassum muticum and Osmundea pinnatifida enzymatic extracts with biological properties". Paper presented in Microbiotec17, 2017. Ota, T.; Enoki, S.. "Chitosan and codfish hydroxyapatite formulation to be used as coating material to circumvent periprosthetic joint infections". Paper presented in Microbiotec17, 2017. 10.2495/dn100281 Costa-Pinto, Ana Rita. "Chondrogenesis-inductive nanofibrous substrate comprising autologous TGF-¿3 and IGF-I from platelet lysates". Paper presented in Term Stem 2016, 2016. Costa-Pinto, Ana Rita. "Isolation and validation of fish roe derived-lipids for biomedical applications". Paper presented in Term Stem 2016, 2016. Costa-Pinto, Ana Rita. "ARTHYMUS - artificial thymus conception: a tissue engineering strategy". Paper presented in 4thTERMIS World Congress, 2015. Costa-Pinto, Ana Rita. "Selective immobilization of PRP-derived growth factors at the surface of nanofibrous substrates for Tissue Engineering and Regenerative Medicine". Paper presented in Society for Biomaterials 2014, 2014. Costa-Pinto, Ana Rita. "Osteogenic potential of human Wharton´s Jelly stem cells on hierarchical starch based scaffolds and its in vivo host response". Paper presented in Term Stem 2013, 2013. Costa-Pinto, Ana Rita. "Influence of conditioned medium in cartilage-like tissue production in co-cultures of articular chondrocytes and Wharton Jelly derived stem cells". Paper presented in 4th Joint ESAO-IFAO Congress 2011, 2011. Costa-Pinto, Ana Rita. "Chondrogenic differentiation of human bone marrow mesenchymal stem cells in chitosan based scaffolds". Paper presented in ICRS 2010 Meeting, 2010. Costa-Pinto, Ana Rita. "Effects of Co-Culture Conditions on Chondrogenic Commitment of Human Wharton Jelly Stem Cells". Paper presented in ICRS 2010 Meeting, 2010. Costa-Pinto, Ana Rita. "The Culture of Human Mesenchymal Stem Cells on Chitosan based Scaffolds in a Multi-Chamber Flow Perfusion Bioreactor for Bone Tissue Engineering". Paper presented in 2nd TERMIS World Congress, 2009. Costa-Pinto, Ana Rita. "In Vivo Responsive Scaffolds with the Ability of In Situ Pore Formation: A Novel Strategy for Bone Tissue Engineering". Paper presented in 2nd TERMIS World Congress, 2009. Costa-Pinto, Ana Rita. "Engineering three-dimensional bone tissue in vitro using chitosan melt based biodegradable scaffolds and hBMSCs". Paper presented in Genostem 3rd Workshop on Mesenchymal Stem Cells Engineering for Connective Tissue Disorders, 2007. Peng, Lin; Zhuo, Ren-Xi. "Biological Evaluation of Porous Chitosan/collagen Scaffolds for Periodontal Tissue Engineering". Paper presented in Day of School of Engineering of University of Minho, Guimarães, 2007. 10.1109/icbbe.2008.220 Costa-Pinto, Ana Rita. "In vivo testing of chitosan based scaffolds for bone tissue engineering". Paper presented in Genostem 4th Workshop on Mesenchymal Stem Cells Engineering for Connective Tissue Disorders, 2007. Costa-Pinto, Ana Rita. "Human Bone Marrow Mesenchymal Stem Cells Differentiation when seeded onto Novel Chitosan-Polyesters fiber mesh Scaffolds: A Bone Tissue Engineering Approach". Paper presented in 1st Annual Meeting of Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 2006. Costa-Pinto, Ana Rita. "Human Bone Marrow Stromal Cells (hBMSCs) Response to Different Electrospun Nanofiber Meshes Topographies: a Study Focusing on the Osteogenic and Chondrogenic Differentiation Potential". Paper presented in 1st Annual Meeting of Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 2006. Costa-Pinto, Ana Rita. "Study of the Osteogenic Behaviour of Primary Cultures of Human Bone Marrow MSCs seeded onto Chitosan-Polyester based Scaffolds". Paper presented in Genostem 2nd Workshop on Mesenchymal Stem Cells Engineering for Connective Tissue Disorders, 2006. Costa-Pinto, Ana Rita. "Factors affecting the adhesion of water stressed Helicobacter pylori to plumbing materials". Paper presented in European Helicobacter Study Group (EHSG) XVIII International Workshop, 2005. 10.1111/j.1523-5378.2005.00342.x Costa-Pinto, Ana Rita. "Novel 3-D Chitosan/Polyester Scaffolds for Bone and Cartilage Tissue Engineering". Paper presented in 19th European Conference on Biomaterials, 2005. Costa-Pinto, Ana Rita. "Preliminary assessment of the behavior of chitosan/polyester scaffolds seeded with mouse mesenchymal stem cells for cartilage and bone tissue engineering". Paper presented in Sessão Pública de Apresentação da Sociedade Portuguesa de Células Estaminais e Terapia Celular, 2005. Lee, Juneseok; Easterling, Andrew. "Study of surface characteristics of water-exposed H. pylori and plumbing materials". Paper presented in IWA International Conference Biofilms 2004: Structure and Activity of Biofilms, 2004. 10.1061/9780784412312.301
Journal article	Ruivo, Carolina F; Bastos, Nuno; Adem, Barbara; Batista, Ines; Duraes, Cecilia; Melo, Carlos A; Castaldo, Stephanie A; et al. "Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression". Gut (2022): gutjnl-2021. http://dx.doi.org/10.1136/gutjnl-2021-324994. 10.1136/gutjnl-2021-324994 A. R. Costa-Pinto; Ana Luísa Lemos; Freni Kekhasharú Tavaria; Manuela Pintado. "Chitosan and Hydroxyapatite Based Biomaterials to Circumvent Periprosthetic Joint Infections". Materials (2021): https://www.mdpi.com/1996-1944/14/4/804. 10.3390/ma14040804 Costa-Pinto, Ana Rita. "In situ forming silk sericin-based hydrogel: A novel wound healing biomaterial". (2021): Accepted Ana do Paço; Simone Aparecida de Bessa Garcia; Joana Leitão Castro; A. R. Costa-Pinto; Renata Freitas. "Roles of the HOX Proteins in Cancer Invasion and Metastasis". Cancers (2020): https://www.mdpi.com/2072-6694/13/1/10. 10.3390/cancers13010010 Rajbux, Chandisree; Pereira, Joel; Selbourne, Maria do Céu; Costa-Pinto, Ana Rita; Poças, Fátima. "Assessment of baby Bibs. GC-MS screening, migration into saliva and insight of toxicity with QSAR tools". Food Control 109 (2020): 106951. http://dx.doi.org/10.1016/j.foodcont.2019.106951. 10.1016/j.foodcont.2019.106951 Dias, Juliana R.; Ribeiro, Nilza; Baptista-Silva, Sara; Costa-Pinto, Ana Rita; Alves, Nuno; Oliveira, Ana L.. "In situ Enabling Approaches for Tissue Regeneration: Current Challenges and New Developments". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00085. Open access • Published • 10.3389/fbioe.2020.00085 Guedes, Marta; Costa-Pinto, Ana R.; Gonçalves, Virgínia M. F.; Moreira-Silva, Joana; Tiritan, Maria Elizabeth; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.. "Sardine Roe as a Source of Lipids To Produce Liposomes". ACS Biomaterials Science & Engineering 6 2 (2020): 1017-1029. http://dx.doi.org/10.1021/acsbiomaterials.9b01462. 10.1021/acsbiomaterials.9b01462 Serôdio, Ricardo; Schickert, Sónia L.; Costa-Pinto, Ana R.; Dias, Juliana R.; Granja, Pedro L.; Yang, Fang; Oliveira, Ana L.. "Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration". Materials Science and Engineering: C 98 (2019): 969-981. http://dx.doi.org/10.1016/j.msec.2019.01.055. 10.1016/j.msec.2019.01.055 Casanova, Marta R.; Alves da Silva, Marta; Costa-Pinto, Ana R.; Reis, Rui L.; Martins, Albino; Neves, Nuno M.. "Chondrogenesis-inductive nanofibrous substrate using both biological fluids and mesenchymal stem cells from an autologous source". Materials Science and Engineering: C 98 (2019): 1169-1178. http://dx.doi.org/10.1016/j.msec.2019.01.069. 10.1016/j.msec.2019.01.069 Rodrigues, Dina; Costa-Pinto, Ana R.; Sousa, Sérgio; Vasconcelos, Marta W.; Pintado, Manuela M.; Pereira, Leonel; Rocha-Santos, Teresa; et al. "Sargassum muticum and Osmundea pinnatifida Enzymatic Extracts: Chemical, Structural, and Cytotoxic Characterization". Marine Drugs 17 4 (2019): 209. http://dx.doi.org/10.3390/md17040209. 10.3390/md17040209 Geão, Catarina; Costa-Pinto, Ana R.; Cunha-Reis, Cassilda; Ribeiro, Viviana P.; Vieira, Sílvia; Oliveira, Joaquim M.; Reis, Rui L.; Oliveira, Ana L.. "Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration". Journal of Materials Science: Materials in Medicine 30 2 (2019): http://dx.doi.org/10.1007/s10856-019-6225-y. 10.1007/s10856-019-6225-y Cartaxo, Ana Luísa; Costa-Pinto, Ana R.; Martins, Albino; Faria, Susana; Gonçalves, Virgínia M. F.; Tiritan, Maria Elizabeth; Ferreira, Helena; Neves, Nuno M.. "Influence of PDLA nanoparticles size on drug release and interaction with cells". Journal of Biomedical Materials Research Part A 107 3 (2018): 482-493. http://dx.doi.org/10.1002/jbm.a.36563. 10.1002/jbm.a.36563 Pinto, Ana. "Electrospun Nanofibrous Meshes Cultured With Wharton's Jelly Stem Cell: An Alternative for Cartilage Regeneration, Without the Need of Growth Factors.". Biotechnology journal (2017): http://europepmc.org/abstract/med/28902474. 10.1002/biot.201700073 Pinto, Ana. "In vitro chondrogenic commitment of human Wharton's jelly stem cells by co-culture with human articular chondrocytes". (2015): http://onlinelibrary.wiley.com/doi/10.1002/term.2085/abstract. 10.1002/term.2085 Pinto, Ana. "Hierarchical scaffolds enhance osteogenic differentiation of human Wharton’s Jelly derived Stem Cells". Biofabrication (2015): http://iopscience.iop.org/article/10.1088/1758-5090/7/3/035009/meta;jsessionid=C7A5303AE6E02D39AF318D7EE34C8E5F.c3.iopscience.cld.iop.org. 10.1088/1758-5090/7/3/035009 Alves da Silva, M.L.; Costa-Pinto, A.R.; Martins, A.; Correlo, V.M.; Sol, P.; Bhattacharya, M.; Faria, S.; Reis, R.L.; Neves, N.M.. "Conditioned medium as a strategy for human stem cells chondrogenic differentiation". Journal of Tissue Engineering and Regenerative Medicine 9 6 (2015): 714-723. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930979489&partnerID=MN8TOARS. 10.1002/term.1812 Oliveira, C.; Costa-Pinto, A.R.; Reis, R.L.; Martins, A.; Neves, N.M.. "Biofunctional nanofibrous substrate comprising immobilized antibodies and selective binding of autologous growth factors". Biomacromolecules 15 6 (2014): 2196-2205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902124225&partnerID=MN8TOARS. 10.1021/bm500346s Costa-Pinto, A.R.; Martins, A.M.; Castelhano-Carlos, M.J.; Correlo, V.M.; Sol, P.C.; Longatto-Filho, A.; Battacharya, M.; Reis, R.L.; Neves, N.M.. "In vitro degradation and in vivo biocompatibility of chitosan-poly(butylene succinate) fiber mesh scaffolds". Journal of Bioactive and Compatible Polymers 29 2 (2014): 137-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896725288&partnerID=MN8TOARS. 10.1177/0883911514521919 Costa-Pinto, A.R.; Vargel, I.; Tuzlakoglu, K.; Correlo, V.M.; Sol, P.C.; Faria, S.; Piskin, E.; Reis, R.L.; Neves, N.M.. "Influence of scaffold composition over in vitro osteogenic differentiation of hBMSCs and in vivo inflammatory response". Journal of Biomaterials Applications 28 9 (2014): 1430-1442. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898975588&partnerID=MN8TOARS. 10.1177/0885328213512385 Martins, A.M.; Kretlow, J.D.; Costa-Pinto, A.R.; Malafaya, P.B.; Fernandes, E.M.; Neves, N.M.; Alves, C.M.; et al. "Gradual pore formation in natural origin scaffolds throughout subcutaneous implantation". Journal of Biomedical Materials Research - Part A 100 A 3 (2012): 599-612. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856214868&partnerID=MN8TOARS. 10.1002/jbm.a.33261 Costa-Pinto, A.R.; Correlo, V.M.; Sol, P.C.; Bhattacharya, M.; Srouji, S.; Livne, E.; Reis, R.L.; Neves, N.M.. "Chitosan-poly(butylene succinate) scaffolds and human bone marrow stromal cells induce bone repair in a mouse calvaria model". Journal of Tissue Engineering and Regenerative Medicine 6 1 (2012): 21-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053033521&partnerID=MN8TOARS. 10.1002/term.391 Alves da Silva, M.L.; Martins, A.; Costa-Pinto, A.R.; Correlo, V.M.; Sol, P.; Bhattacharya, M.; Faria, S.; Reis, R.L.; Neves, N.M.. "Chondrogenic differentiation of human bone marrow mesenchymal stem cells in chitosan-based scaffolds using a flow-perfusion bioreactor". Journal of Tissue Engineering and Regenerative Medicine 5 9 (2011): 722-732. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053146421&partnerID=MN8TOARS. 10.1002/term.372 Costa-Pinto, A.R.; Reis, R.L.; Neves, N.M.. "Scaffolds based bone tissue engineering: The role of chitosan". Tissue Engineering - Part B: Reviews 17 5 (2011): 331-347. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052982295&partnerID=MN8TOARS. 10.1089/ten.teb.2010.0704 Correlo, V.M.; Costa-Pinto, A.R.; Sol, P.; Covas, J.A.; Bhattacharya, M.; Neves, N.M.; Reis, R.L.. "Melt Processing of Chitosan-Based Fibers and Fiber-Mesh Scaffolds for the Engineering of Connective Tissues". Macromolecular Bioscience 10 12 (2010): 1495-1504. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649871051&partnerID=MN8TOARS. 10.1002/mabi.201000011 Alves Da Silva, M.L.; Martins, A.; Costa-Pinto, A.R.; Costa, P.; Faria, S.; Gomes, M.; Reis, R.L.; Neves, N.M.. "Cartilage tissue engineering using electrospun PCL nanofiber meshes and MSCs". Biomacromolecules 11 12 (2010): 3228-3236. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650288788&partnerID=MN8TOARS. 10.1021/bm100476r Costa-Pinto, A.R.; Correlo, V.M.; Sol, P.C.; Bhattacharya, M.; Charbord, P.; Delorme, B.; Reis, R.L.; Neves, N.M.. "Osteogenic differentiation of human bone marrow mesenchymal stem cells seeded on melt based chitosan scaffolds for bone tissue engineering applications". Biomacromolecules 10 8 (2009): 2067-2073. http://www.scopus.com/inward/record.url?eid=2-s2.0-68849110473&partnerID=MN8TOARS. 10.1021/bm9000102 Correlo, V.M.; Boesel, L.F.; Pinho, E.; Costa-Pinto, A.R.; Alves Da Silva, M.L.; Bhattacharya, M.; Mano, J.F.; Neves, N.M.; Reis, R.L.. "Melt-based compression-molded scaffolds from chitosan-polyester blends and composites: Morphology and mechanical properties". Journal of Biomedical Materials Research - Part A 91 2 (2009): 489-504. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349451980&partnerID=MN8TOARS. 10.1002/jbm.a.32221 Oliveira, J.T.; Correlo, V.M.; Sol, P.C.; Costa-Pinto, A.R.; Malafaya, P.B.; Salgado, A.J.; Bhattacharya, M.; et al. "Assessment of the suitability of chitosan/polybutylene succinate scaffolds seeded with mouse mesenchymal progenitor cells for a cartilage tissue engineering approach". Tissue Engineering - Part A. 14 10 (2008): 1651-1661. http://www.scopus.com/inward/record.url?eid=2-s2.0-53049107204&partnerID=MN8TOARS. 10.1089/ten.tea.2007.0307 Costa-Pinto, A.R.; Salgado, A.J.; Correlo, V.M.; Sol, P.; Bhattacharya, M.; Charbord, P.; Reis, R.L.; Neves, N.M.. "Adhesion, proliferation, and osteogenic differentiation of a mouse mesenchymal stem cell line (BMC9) seeded on novel melt-based chitosan/polyester 3D porous scaffolds". Tissue Engineering - Part A. 14 6 (2008): 1049-1057. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549109159&partnerID=MN8TOARS. 10.1089/ten.tea.2007.0153 Azevedo, N. F.; Pinto, A. R.; Reis, N. M.; Vieira, M. J.; Keevil, C. W.. "Shear Stress, Temperature, and Inoculation Concentration Influence the Adhesion of Water-Stressed Helicobacter pylori to Stainless Steel 304 and Polypropylene". Applied and Environmental Microbiology 72 4 (2006): 2936-2941. http://dx.doi.org/10.1128/aem.72.4.2936-2941.2006. 10.1128/aem.72.4.2936-2941.2006

Intellectual property

Provisional application for patent

2019. "Paste of chitosan and hydroxyapatite, methods of obtaining and uses therof".
Protected

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2020	A biocompatible and injectable hydrogel for the sustained treatment of neurodegenerative diseases	TERMIS European Chapter Meeting 2020 (Manchester, United Kingdom)
2019	Pancreatic Cancer Stem Cells Coordinate an Organized Exosomes Communication Network that Contributes to Pancreatic Cancer Progression	ONCOLOGY SYMPOSIUM – UNIFESP - Advances in Cancer Research (São Paulo, Brazil)
2018	BIOTHERAPIES – Bioengineered Therapies for Infectious Diseases and Tissue Regeneration	1st National Marathon of Circular Economy Projects (Sines, Portugal)
2018	iCOD – Innovative technologies for valorization of by-products of codfish processing	1st National Marathon of Circular Economy Projects (Sines, Portugal)
2017	Thermal Induced Silk fibroin membranes for periodontal guided tissue regeneration	MATBIM 2017 conference - 4th international meeting on Material/Bioproduct Interaction (Porto, Portugal)
2017	Mesenchymal Stem Cells as Key Tools for Cartilage and Bone Regeneration	Instituto Superior Técnico (Lisboa, Portugal)
2017	Stem Cells and Chitosan based Scaffolds for Bone Tissue Engineering Applications”, Ciclo de Seminários em Engenharia Biomédica	Centre of Biotechnology and Fine Chemistry (CBQF) in Biotechnology School of Catholic University (Porto, Portugal)
2017	Potencial de células estaminais e biomateriais à base de quitosano para engenharia de tecido ósseo	Conferências em Biotecnologia, Centre of Biotechnology and Fine Chemistry (CBQF) in Biotechnology School of Catholic University (Porto, Portugal)
2016	Chondrogenesis-inductive nanofibrous substrate comprising autologous TGF-¿3 and IGF-I from platelet lysates	Chem2Nature First School (Guimarães, Portugal)
2014	ARTHYMUS - artificial thymus conception: a tissue engineering strategy	1st ICVS-3B´s Meeting (Braga, Portugal)
2013	Adult stem cells for TERM: sources and manipulation	3rd 3B’s symposium on Biomaterials and Stem cells in Regenerative Medicine, University of Minho (Guimarães, Portugal)
2013	Chitosan based Scaffolds for Bone Tissue Engineering	V Symposium on Bioengineering, University of Porto (Porto, Portugal)
2012	Fetal stem cells obtained from Amniotic Fluid and Wharton´s Jelly expanded using platelet lysate for tissue engineering applications	Term Stem 2012 (Guimarães, Portugal)
2012	Adult stem cells: sources and manipulation	2nd 3B’s symposium on Biomaterials and Stem cells in Regenerative Medicine, University of Minho (Guimarães, Portugal)
2011	Degradation kinetics and host response of chitosan based scaffolds	IBB 2nd Annual Scientific Meeting (Braga, Portugal)
2011	In vitro degradation and biocompatibility of chitosan-PBS based scaffolds	Week of School of Engineering of University of Minho (Guimarães, Portugal)
2011	Chitosan based Scaffolds for Bone Tissue Engineering	1st 3B’s symposium on Biomaterials and Stem cells in Regenerative Medicine (Guimarães, Portugal)
2011	Chitosan based Scaffolds for Bone Tissue Engineering	Seminar in Centro de Biomedicina Molecular e Estrutural, University of Algarve (Faro, Portugal)
2010	Enhanced Chondrogenic Differentiation of Human Bone Marrow Stromal Cells (hBMSCs) Seeded in Nanofiber Meshes under Flow Perfusion Stimulation	5th SPCE-TC (Guimarães, Portugal)
2010	Co-culture of Human Wharton Jelly Stem Cells with Human Articular Chondrocytes Provides a Suitable Environment for their Chondrogenic Commitment	5th SPCE-TC (Guimarães, Portugal)
2010	Evaluation of potential of Hiearchical starch-based fibrous scaffolds for bone tissue engineering applications	TERMIS EU 2010 (Galway, Ireland)
2010	Evaluation of the Potential of Hierarchical Starch-based Fibrous Scaffold for Bone Tissue Engineering Applications	IBB 2nd Annual Scientific Meeting (Braga, Portugal)
2010	Tissue response and in vitro degradation of chitosan-PBS based scaffolds	TERMIS-AP 2010 Meeting (Sidney, Australia)
2010	Polycaprolactone nanofiber meshes for cartilage tissue engineering using dynamic culture	TERMIS-AP 2010 Meeting (Sidney, Australia)
2010	Chondrogenic differentiation of human bone marrow mesenchymal stem cells in a flow perfusion bioreactor	Chondrogenic differentiation of human bone marrow mesenchymal stem cells in a flow perfusion bioreactor (Sidney, Australia)
2009	Scaffold Composition Conditions the Osteogenic Differentiation in Flow Perfusion Culture of Human Mesenchymal Stem Cells	2nd TERMIS World Congress in conjunction with 2009 Seoul Stem Cell Symposium (Seul, South Korea)
2008	Potential of human adult stem cells and natural-based biodegradable scaffolds for bone tissue engineering	6th Marie Curie Cutting-Edge Conference - “Stem cells: from the petri dish to the clinical application (Faro, Portugal)
2008	Comparative study of the multidifferentiation potential of Human Wharton’s Jelly and Amniotic Fluid derived Stem Cells	Termis-EU (Porto, Portugal)
2007	Biological performance of human bone marrow mesenchymal stem cells cultured onto novel chitosan polyester scaffolds	TERMIS-AP 2007 Tissue Engineering International & Regenerative Medicine Society Meeting (Tokyo, Japan)
2006	Study of the Osteogenic Behaviour of Primary Cultures of Human Bone Marrow MSCs when seeded onto Chitosan-Polyester based Scaffolds	Genostem 2nd Workshop on Mesenchymal Stem Cells Engineering for Connective Tissue Disorders (Porto, Portugal)
2006	Study of the Osteogenic Behaviour of Adult Stem Cells and Novel Melt-Processable Chitosan-Polyester Based Scaffolds for Bone Tissue Engineering	Regenerate World Congress on Tissue Engineering and Regenerative Medicine-TERMIS (Pittsburgh, United States)
2006	Human Bone Marrow Mesenchymal Stem Cells Differentiation when seeded onto Novel Chitosan-Polyesters fiber mesh Scaffolds: A Bone Tissue Engineering Approach	ESF-EMBO Symposium Conference on Stem Cells in Tissue Engineering (Sant Feliu de Guixols, Spain)
2006	Gellan Gum Hydrogels as Supports for Human Articular Chondrocytes and Human Bone Marrow Cells for Cartilage Tissue Engineering Applications: A Comparative Study	ESF-EMBO Symposium Conference on Stem Cells in Tissue Engineering (Sant Feliu de Guixols, Spain)
2005	The role of biofilms in the transmission of Helicobacter pylori through drinking water	Micro-Biotec-2005 Congress (Portugal)
2005	Preliminary Assessment of the Potential of Chitosan/Polyester Based Scaffolds for Bone and Cartilage Tissue Engineering	SFB 2005 (Memphis, United States)
2005	Evaluation of the Adhesion, Proliferation and Differentiation of a Mouse Mesenchymal Stem Cell line on Novel Chitosan/Polyester Based Scaffolds	ESB 2005-19th European Conference on Biomaterials (Sorrento, Italy)
2005	Preliminary Assessment of the Behaviour of Chitosan/Poly(Butylene Succinate) Scaffolds Seeded with Mouse Mesenchymal Stem Cells for Cartilage Tissue Engineering	ESB 2005-19th European Conference on Biomaterials (Sorrento, Italy)
2005	Behaviour of Human Bone Marrow Mesenchymal Stem Cells Seeded on Fiber Bonding Chitosan Polyester based for Bone Tissue Engineering Scaffolds	8th TESI Annual Meeting (Shangai, China)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021 - Current	Algae antioxidant and polysaccharide rich derived extracts from Fucus vesiculosus and Porphyra dioica as potential therapeutic strategies for pancreatic cancer Co-supervisor of Paulo Ricardo Santos Pontes da Nova
2020 - Current	Multifunctional natural derived peptide extracts for skin care Co-supervisor	Biotechnology (PhD) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2019 - Current	Novel method for prevention of Periprosthetic Joint Infections: Chitosan & Hydroxyapatite composite in paste form Supervisor	Engenharia Biomédica Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2019 - 2020	Study of chemical migration potential and cytotoxic evaluation of Baby bibs Co-supervisor	European Master of Science in Food Science, Technology and Business (BiFTec) (Master) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2018 - 2018	Chitosan-based biomaterials and hydroxyapatite for bone regeneration Supervisor	Engenharia Biomédica (Degree) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2017 - 2017	Cell proliferation assessment by DNA and Protein quantification Supervisor	Engenharia Biomédica (Other) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2015 - 2016	Establishment of endothelial and cancer cells co-culture systems Co-supervisor	Engenharia Biomédica (Master) Universidade do Minho, Portugal
2014 - 2015	Optimization of the size of biodegradable polymeric nanoparticles as intracellular drug delivery devices Co-supervisor	Engenharia Biomédica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2014	Immobilization of specific growth factors from platelet lysate at the surface of electrospun nanofibers for tissue engineering applications Co-supervisor	Engenharia Biomédica (Master) Universidade do Minho, Portugal
2011 - 2012	Fetal stem cells obtained from Amniotic Fluid and Wharton´s Jelly expanded using platelet lysate for tissue engineering applications Co-supervisor	Biomaterials Biodegradables and Biomimetics, Portugal
2009 - 2009	Study of the behavior of human bone marrow stromal cells (hBMSC’s) through an osteogenic differentiation upon micro and nano structured polymeric surfaces Co-supervisor	Biomaterials Biodegradables and Biomimetics, Portugal
2008 - 2009	Osteogenic potential of human Wharton’s jelly on stromal cells cultured on hierarchical fibrous-based scaffold Co-supervisor	Genética e Biotecnologia (Master) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2008 - 2008	Adult stem cells: Isolation, culturing and differentiation Co-supervisor	Biologia Aplicada (Scientific initiation) Universidade do Minho, Portugal
2008 - 2008	Tissue Engineering – Present or Future Co-supervisor	Medicina (Other) Universidade do Minho, Portugal
2007 - 2008	Effects of biomaterials on gene expression in bone marrow stromal cells and umbilical cord cells Co-supervisor	Biomaterials Biodegradables and Biomimetics, Portugal
2006 - 2006	Study of the role of the bone morphogenetic proteins in spine pathology Co-supervisor	Medicina (Other) Universidade do Minho, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2017 - Current	4rd Edition of MATBIM Packaging Material / Bioproduct Interactions (MATBIM 2017) (2017) Conference	Universidade Católica Portuguesa Centro Regional do Porto, Portugal
2013 - Current	TERM STEM 2013 (2013) Congress (Member of the Organising Committee)	Universidade do Minho, Portugal
2011 - Current	4th Joint ESAO-IFAO Congress 2011 and Young ESAO 2011 (2011) Conference (Member of the Organising Committee)	Universidade do Minho, Portugal
2008 - Current	Termis-EU 2008 (2008) Conference (Member of the Organising Committee)	Universidade do Minho, Portugal
2007 - Current	2nd Workshop on Mesenchymal Stem Cells Engineering for Connective Tissue Disorders (2007) Congress (Member of the Organising Committee)	Universidade do Minho, Portugal
2005 - Current	1st Annual Meeting of Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC) (2005) Congress (Member of the Organising Committee)	Universidade do Minho, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2019	Biofunctional silk-fibroin membranes with antioxidant properties for the treatment of chronic wounds (Thesis) Main arguer	Ana Sofia Ferreira Fernandes (Master) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2018	Understanding the Potential of PDMAEMA-Based Vectors for Gene Therapy of the Retina (Thesis) Arguer	Diogo Miguel Barros Bitoque (PhD) Universidade Nova de Lisboa, Portugal
2011	Development of non-viral vectors for genetic therapy (Thesis) Main arguer	Ana Rita Reis Mateus (Master) Universidade do Algarve - Campus de Gambelas, Portugal

Consulting

	Activity description	Institution / Organization
2020 - Current	Consultancy Services for Project Peer Review of the Science Fund of the Republic of Serbia

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2013 - 2013	Biocompatibilidade	Engenharia Biomédica (Mestrado integrado)	Universidade do Minho, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2020 - Current	Invited expert reviewer for Romanian Executive Agency for Higher Education, Research, Development and Innovation Funding for Experimental Demonstrative Project Call (PED 2019). Evaluator	Romanian Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania
2019 - Current	M.ERA-NET Call 2019 Evaluator	Horizon 2020, Belgium	European Union
2016 - Current	Bulgarian National Science Fund (BNSF), Bilateral and Biological Sciences. Evaluator	German-Israeli Foundation for Scientific Research and Development, Israel
2016 - Current	4th Call for Proposals of the International Fellowship Programme WHRI-ACADEMY (FP7 Marie Curie COFUND scheme).	Queen Mary University of London, United Kingdom	European Commission Seventh Framework Programme for Research and Technological Development

Interview (tv / radio show)

	Program	Topic
2019/11/21 - Current	Programa da manhã: Dia mundial do Cancro do Pancreas	A investigação no cancro do pâncreas – Dia Mundial do Cancro do Pâncreas

Journal scientific committee

	Journal title (ISSN)	Publisher
2021 - Current	Molecules

Distinctions

Award

2010	Best oral presentation Universidade do Minho, Portugal
2009	Travel award
2007	Outstanding Student/Young Investigator award for best oral presentation
2002	Student Merit award Universidade do Minho, Portugal

Other distinction

2020	Honored mention 4th Edition of “Prémio Rui Osório de Castro / Millennium BCP” with the work “Terapia dirigida para neuroblastoma com exossomas e RNA de interferência”