???global.info.a_carregar???
Rui João de Sousa Loureiro. Junior Researcher at Coimbra Chemistry Center - Institute of Molecular Sciences, University of Coimbra. Completed the PhD in Systems Biology by the University of Lisbon in 2019, the MSc in Molecular Biomedicine in 2012 by the University of Aveiro and the BSc in Biomedical Sciences in 2010 by the University of Aveiro. Recipient of 5 prizes or distinctions.
Identification

Personal identification

Full name
Rui João de Sousa Loureiro

Citation names

  • Loureiro, Rui João
  • Rui J Loureiro
  • JS Loureiro R
  • Loureiro RJS
  • Loureiro Rui JS

Author identifiers

Ciência ID
0311-5F5F-DE7F
ORCID iD
0000-0002-1957-1853

Email addresses

  • ruijoaoloureiro@gmail.com (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2015/01/01 - 2019/11/26
Concluded
 Biologia (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Disclosing the aggregation mechanism of ß2-microglobulin in amyloid disease " (THESIS/DISSERTATION)
 Approved with distinction
2010/09/02 - 2012/07/17
Concluded
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
"Perfis de Resistência Microbiana no Hospital Infante D. Pedro" (THESIS/DISSERTATION)
 17/20
2007/09/19 - 2010/06/28
Concluded
 Ciências Biomédicas (Licenciatura)
Universidade de Aveiro, Portugal
"n/a" (THESIS/DISSERTATION)
 15/20
Affiliation

Others

Category
Host institution 		Employer
2020/09/30 - Current Junior Researcher at Centro de Química de Coimbra - Institute of Molecular Sciences, University of Coimbra Universidade de Coimbra Centro de Química de Coimbra, Portugal
Universidade de Coimbra, Portugal
2015/01/01 - 2019/11/26 PhD student Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2018/04/02 - 2018/06/29 Visiting PhD student Harvard University Department of Chemistry and Chemical Biology, United States
Harvard University Department of Chemistry and Chemical Biology, United States
2013/09/03 - 2014/03/26 Research trainee in the Molecular Neurogenetics Group of the Instituto de Neurociencias de Alicante Instituto de Neurociencias, Spain
Instituto de Neurociencias, Spain
2012/09/03 - 2013/07/05 Research trainee in the Clinical Research Lab of the Centre for Cell Biology of the University of Aveiro. Universidade de Aveiro, Portugal
2010/09/02 - 2012/07/17 MSc student Universidade de Aveiro, Portugal
Projects

Contract

Designation Funders
2020/09/30 - Current Leads4FLU - Novel antivirals against Influenza: NS1 target validation and lead discovery
POCI-01-145-FEDER-032572
Researcher
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2015/01/01 - 2019/11/26 Biosystems & Integrative Sciences Institute
info:eu-repo/grantAgreement/FCT/5876/147256/PT
PhD Student Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/11 - 2019/11 The Physical Basis of Disease: The case of dialysis related amyloidosis
PTDC/FIS-OUT/28210/2017
PhD Student Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/09 - 2014/03 Patterns of MNB/DYRK1A substrate recognition
2013-1-PT1-LEO02-15658
Researcher
European Commission
Concluded
2011/09 - 2013/07 An educational intervention to improve the use of antibiotics in Portuguese Health Professionals: cluster-randomized trial.
PTDC/SAU-ESA/105530/2008
Researcher
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Daniela Amado; Otávio A. Chaves; Rui Loureiro; Zaida L. Almeida; Catarina S. H. Jesus; Carlos Serpa; Rui M. M. Brito. "(One) microsecond dynamics and volume expansion in a single turn of B-hairpin peptide chignolin upon ultra-fast pH-jump". Paper presented in Biophysics Festival - 2nd Meeting of Young Biophysicists, 2022.
  2. Otávio Augusto Chaves; Andreia F.C. Tuna; Rui Loureiro; Zaida L. Almeida; João Pina; Rui M. M. Brito; Carlos Serpa. "Biophysical characterization of the interaction between human serum albumin and two commercial azo food dyes". Paper presented in Biophysics Festival - 2nd Meeting of Young Biophysicists, 2022.
  3. Rui João Loureiro; Andreia Cunha; Nícia Rosário-Ferreira; Rui M. M. Brito. "Non-structural protein 1 (NS1) as a drug target for seasonal and pandemic Influenza". Paper presented in Biophysics Festival - 2nd Meeting of Young Biophysicists, 2022.
  4. Rui João Loureiro; Andreia Cunha; Rui M. M. Brito. "Non-structural protein 1 (NS1) interaction with TRIM25 as a target for influenza antiviral therapy". Paper presented in EJIBCE 2021, 2021.
  5. Rui João Loureiro; Andreia Cunha; Rui M. M. Brito. "Non-structural protein 1 (NS1) interaction with PI3K as a target for influenza antiviral therapy". Paper presented in EMBO Workshop on Advances and Challenges in Biomolecular Simulations, 2021.
  6. Rui J. Loureiro, Diogo Vila-Viçosa, Miguel Machuqueiro, Eugene I. Shakhnovich, Patrícia F.N. Faísca. "The early phase of the ß2m aggregation mechanism: an integrative computational analysis based on the D76N mutant and ¿N6 variant". Paper presented in EJIBCE 2019, 2019.
  7. Rui J. Loureiro, Diogo Vila-Viçosa, Miguel Machuqueiro, Eugene I. Shakhnovich, Patrícia F.N. Faísca. "The dimerization phase of the ß2m aggregation mechanism: An integrative computational analysis based on the D76N mutant and ¿N6 variant.". Paper presented in Workshop on Integrative Approaches to Protein Folding & Aggregation, 2019.
  8. Loureiro, Rui João; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Shakhnovich, Eugene; Faísca, Patrícia. "The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: insights from molecular simulations of D76N mutant". Paper presented in EJIBCE 2018, 2018.
    10.3390/mol2net-04-06085
  9. Rui J. Loureiro, Diogo Vila-Viçosa, Miguel Machuqueiro, Eugene I. Shakhnovich, Patrícia F.N. Faísca. "The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: Insights from molecular simulations of D76N mutant". Paper presented in Biomolecules and Nanostructures 6, 2017.
  10. Rui J. Loureiro, Diogo Vila-Viçosa, Miguel Machuqueiro, Patrícia F.N. Faísca. "Novel insights into beta-2-microglobulin amyloidogenesis from molecular simulations: the importance of unstructured termini in the aggregation cascade". Paper presented in Protein misfolding in disease - Toxic aggregation-prone proteins in aging and age-related diseases: from structure to pathology and spreading, 2016.
  11. Rui J. Loureiro, Diogo Vila-Viçosa, Miguel Machuqueiro, Patrícia F.N. Faísca. "The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: insights from molecular simulations of D76N mutant". Paper presented in EMBO Practical Course on Integrative modelling of biomolecular interactions, 2016.
  12. Rui J. Loureiro, Patrícia F.N. Faísca. "Molecular events triggering the aggregation cascade in ß2-microglobulin amyloidosis". Paper presented in EJIBCE 2015, 2015.
Journal article
  1. Nuno F B Oliveira; Filipe E P Rodrigues; João N M Vitorino; Rui João Loureiro; PFN Faisca; Miguel Machuqueiro. "Predicting stable binding modes from simulated dimers of the D76N mutant of ß2-microglobulin". Computational and Structural Biotechnology Journal (2021): https://www.sciencedirect.com/science/article/pii/S2001037021003883.
    10.1016/j.csbj.2021.09.003
  2. Loureiro RJS, Faísca PFN, The early phase of ß2-microglobulin aggregation: Perspectives from Molecular Simulations,. "The Early Phase of ß2-Microglobulin Aggregation: Perspectives From Molecular Simulations.". Frontiers in molecular biosciences 7 (2020): https://europepmc.org/articles/PMC7550760.
    Published • 10.3389/fmolb.2020.578433
  3. Loureiro, Rui João. "The Early Phase of ß2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ¿N6 Variant". Biomolecules (2019): http://dx.doi.org/10.3390/biom9080366.
    10.3390/biom9080366
  4. Loureiro, Rui J. S.; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Shakhnovich, Eugene I.; Faísca, Patricia F. N.. "A tale of two tails: The importance of unstructured termini in the aggregation pathway of ß2-microglobulin". Proteins: Structure, Function, and Bioinformatics 85 11 (2017): 2045-2057. http://dx.doi.org/10.1002/prot.25358.
    Published • 10.1002/prot.25358
  5. Loureiro, Rui João; Roque, Fátima; Teixeira Rodrigues, António; Herdeiro, Maria Teresa; Ramalheira, Elmano. "O uso de antibióticos e as resistências bacterianas: breves notas sobre a sua evolução". Revista Portuguesa de Saúde Pública 34 1 (2016): 77-84. http://dx.doi.org/10.1016/j.rpsp.2015.11.003.
    Published • 10.1016/j.rpsp.2015.11.003
Thesis / Dissertation
  1. Loureiro, Rui. "Disclosing the aggregation mechanism of ß2-microglobulin in amyloid disease". PhD, Universidade de Lisboa Faculdade de Ciências, 2019.
  2. Loureiro, Rui. "Perfis de resistência microbiana no Hospital Infante D. Pedro". Master, Universidade de Aveiro, 2012.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/02/17 The early phase of the ß2m aggregation mechanism: an integrative computational analysis framed on the D76N mutant and ¿N6 variant 1st BioSIM Cycle of Conferences
BioSIM (Porto, Portugal)
2018/07/06 The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: Insights from molecular simulations of D76N mutant Biophysics Party
ITQB (Oeiras, Portugal)
2016/07/04 "The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: insights from molecular simulations of D76N mutant." flash poster presentation EMBO Practical Course on Integrative modelling of biomolecular interactions
EMBO (Barcelona, Spain)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/10/06 - 2017/10/07 Member of the Organizing Committee of the 2017 BioSys Retreat, an annual meeting of the BioSys PhD programme students. (2017/10/06 - 2017/10/07)
Meeting (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/06/03 - 2022/06/03 Biophysics Festival - 2nd Meeting of Young Biophysicists, Universidade de Aveiro, Aveiro, Portugal
Meeting
 Biophysics Festival - 2nd Meeting of Young Biophysicists
2021/12/20 - 2021/12/20 Encontro de Jovens Investigadores de Biologia Computacional Estrutural 2021 (EJIBCE 2021), Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal
Meeting
 Encontro de Jovens Investigadores de Biologia Computacional Estrutural 2021 (EJIBCE 2021)
2021/12/15 - 2021/12/15 Coimbra Chemistry Center Day 2021, Auditório da Reitoria da Universidade de Coimbra, Coimbra, Portugal
Meeting
 Coimbra Chemistry Center Day 2021
2021/11/02 - 2021/11/04 ELIXIR 3D-Bioinfo Community in Structural Bioinformatics
Meeting
 ELIXIR 3D-Bioinfo Community in Structural Bioinformatics
2021/10/18 - 2021/10/21 EMBO Workshop on Advances and Challenges in Biomolecular Simulations, Virtual Event
Workshop
 EMBO Workshop on Advances and Challenges in Biomolecular Simulations
2021/09/13 - 2021/09/17 Vienna Summer School on Drug Design 2021, Virtual Event
Workshop
 Vienna Summer School on Drug Design 2021
2021/06/14 - 2021/06/16 7th International Iberian Biophysics Congress, Universidade de Coimbra, Coimbra, Portugal
Conference
 7th International Iberian Biophysics Congress
2019/12/20 - 2019/12/20 EJIBCE 2019
Meeting
 EJIBCE 2019
2019/06/11 - 2019/06/12 Workshop on Integrative Approaches to Protein Folding & Aggregation
Conference
2018/12/21 - 2018/12/21 EJIBCE 2018
Meeting
2017/07/03 - 2017/07/05 Participation in the BioISI research centre stand exhibition in Ciência 2017 outreach event.
Meeting
 Ciência 2017
2017/05/10 - 2017/05/14 Biomolecules and Nanostructures 6 Conference
Conference
2017/02/09 - 2017/02/09 Chemistry and Biochemistry Postgraduate Students Meeting
Meeting
2016/12/21 - 2016/12/21 EJIBCE 2016
Meeting
2016/09/12 - 2016/09/16 "Protein misfolding in disease - Toxic aggregation-prone proteins in aging and age-related diseases: from structure to pathology and spreading" Jacques Monod Conference
Conference
2016/07/23 - 2016/07/24 2016 BioSys Retreat
Meeting
2015/12/18 - 2015/12/18 EJIBCE 2015
Meeting
2015/12/11 - 2015/12/11 1st BioISI Annual Meeting
Meeting
2015/09/02 - 2015/09/11 2015 Summer School in Computational Biology
Other

Ad Hoc journal article review

Journal title (ISSN) Publisher
2020/12/01 - 2021/01/26 Scientific Reports (2045-2322) Springer Nature
2020/12/01 - 2021/01/05 BMC Bioinformatics (1471-2105) Springer Nature

Other jury / evaluation

Activity description Institution / Organization
2022/09/08 - 2022/09/08 Membership of the evaluation jury of a bachelor traineeship project as examiner. Universidade de Coimbra, Portugal
Distinctions

Other distinction

2021 Fee waiver for the 2021 EMBO Worksop on Advances and Challenges in Biomolecular Simulations
European Molecular Biology Laboratory, Germany
2016 Travel Grant for the 2016 EMBO Practical Course on Integrated modelling of biomolecular interactions.
EMBO Press, Germany
2015 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2013 Leonardo da Vinci program fellowship for a professional internship in the Instituto de Neurociências de Alicante
2007 Presence in the excellence board of the José Loureiro Botas High School, distinction awarded to the best students of the school