???global.info.a_carregar???
Tiago Outeiro. Concluiu o(a) Mestrado integrado em Bioquímica em 1998 pelo(a) Universidade do Porto Faculdade de Ciências, Mestrado integrado em Bioquímica em 1998 pelo(a) Universidade do Porto Faculdade de Ciências, Doutoramento em Ciências Biomédicas em 2004 pelo(a) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar e Doutoramento em Ciências Biomédicas em 2004 pelo(a) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar. É Professor Catedrático no(a) Georg-August-Universität Göttingen, Full Professor, Director of the Department of Experimental Neurodegeneration no(a) Georg-August-Universität Göttingen e Professor Catedrático no(a) Into Newcastle University. Publicou 568 artigos em revistas especializadas. Possui 11 capítulo(s) de livros. Possui 1 patente(s) registada(s). Recebeu 10 prémio(s) e/ou homenagens. Nas suas atividades profissionais interagiu com 10147 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Teses de doutoramento - 2014; Sistema nervoso simpático; Hipertensão; Núcleo hipotalâmico paraventricular; Órgãos-alvo; Barorreflexo; Doença de Parkinson; Saccharomyces cerevisiae; Fosforilação; Agregação celular; Teses de mestrado - 2013; lpha-synuclein; Autophagy; Mitophagy; Sirtuins; Chronological aging; Yeast; Synucleinopathies; alpha-synuclein; Science & Technology; Journal Article; Cromatina; Doença de Alzheimer; Aging; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Models, Animal; Drosophila; Enzyme Inhibitors; Female; Glycosylation; Hippocampus; Humans; Induced Pluripotent Stem Cells; Male; Mice; Mice, Transgenic; Neurodegenerative Diseases; Protein Aggregation, Pathological; Protein Processing, Post-Translational; Pyruvaldehyde; Rats; Yeasts; alpha-Synuclein; Genómica Funcional e Estrutural; Neurociências; Peixe-zebra; Trifosfato de adenosina; Modelos genéticos; Biologia computacional; Teses de mestrado - 2010; accidental cell death; apoptosis; autophagic cell death; autophagy; caspases; mitochondrial membrane permeabilization; mitotic catastrophe; model organism; necrosis; reactive oxygen species; regulated cell death; Post-translational Modi¿cations; Parkinson's Disease; Proteomics; a-synuclein; Quinurenina 3-mono-oxigenase; Doença de Huntington; Doenças neurodegenerativas; Terapêutica; Teses de doutoramento - 2013; Alpha-synuclein; a-syn oligomers; Parkinson's disease; Cell aggregation; Cell death; Sir2; Parkinson disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylation; Cell Membrane; Cerebral Cortex; Dopaminergic Neurons; Gene Deletion; Gene Knockdown Techniques; HEK293 Cells; Lysine; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neuroprotection; Parkinson Disease; Protein Aggregates; Protein Binding; Sirtuin 2; Biomedicina; Prevenção; Fisiologia; Investigação de translação; Glycation; Parkinson¿s disease; Neurodegeneration; Leveduras; Deficiências na proteostase; Hsp27; Hsp70; Methylglyoxal; Familial amyloidotic polyneuropathy; FTICR; Saliva; Systemic amyloidosis; Transthyretin; General; Alfa-sinucleína; Autofagia; Teses de mestrado- 2013; Complementação de fluorescência bimolecular; Oligomerização; Mutações; Teses de doutoramento - 2016; Ataxia de Friedreich; Heterocromatina; Transcrição genética; Expansão das repetições de trinucleotídeos; Domínio/Área Científica::Ciências Médicas::Medicina Básica; Biologia celular; RNA interferência; Teses de mestrado; Variações do número de cópias de DNA; Genes modificadores; Biologia humana; Fósforilação; Teses de mestrado - 2012; Secretion; Hyperexpression techniques; Oligomers; Toxicity; Cytotoxicity; Immunoblotting; Immunocytochemistry; Fluorescence microscopy; Corpos de Lewy; Drug discovery; Hyperkinesia; Hypokinesia; Movement disorders; Zebrafish models; Neurology; Clinical Neurology; Teses de doutoramento - 2015; Proteínas tau; LRRK2; Teses de doutor
Identificação

Identificação pessoal

Nome completo
Tiago Outeiro

Nomes de citação

  • Outeiro, Tiago

Identificadores de autor

Ciência ID
BC14-20AB-8D68
ORCID iD
0000-0003-1679-1727

Moradas

  • Waldweg 33, Department of Experimental Neurodegeneration, 37073, Goettingen, N/A, Alemanha (Profissional)

Websites

  • http://www.neurodegeneration.uni-goettingen.de/ (Académico)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Formação
Grau Classificação
2004
Concluído
Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Yeast as a model to investigate the molecular basis of neurodegeneration" (TESE/DISSERTAÇÃO)
Aprovado por unanimidade
2004
Concluído
Ciências Biomédicas (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Yeast as a Model Organism to Study Diseases of Protein Misfolding" (TESE/DISSERTAÇÃO)
1998
Concluído
Bioquímica (Mestrado integrado)
Universidade do Porto Faculdade de Ciências, Portugal
16.3 valores
1998
Concluído
Formação de Formadores (Curso de Especialização Tecnológica)
Instituto do Emprego e Formação Profissional, Portugal
Concluido
1998
Concluído
Bioquímica (Mestrado integrado)
Universidade do Porto Faculdade de Ciências, Portugal
16.3 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2015/01/01 - 2019/12/31 Investigador principal (carreira) (Investigação) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2007 - 2013 Investigador Coordenador (carreira) (Investigação) Instituto de Medicina Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2017/11/01 - Atual Professor Catedrático (Docente Universitário) Into Newcastle University, Reino Unido
2011/01/01 - Atual Professor Catedrático (Docente Universitário) Georg-August-Universität Göttingen, Alemanha
2015 - 2018 Professor Catedrático (Docente Universitário) iNOVA4Health, Portugal
2013/01/01 - 2016 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2011/01/01 - Atual Full Professor, Director of the Department of Experimental Neurodegeneration Georg-August-Universität Göttingen, Alemanha
2011/01/01 - 2014/12/31 Principal Investigator of the Neurodegeneration Unit at IMM (associate Unit due to my postition as Full Professor at the University Medical Center Goettingen, Germany Instituto de Medicina Molecular, Portugal
2004/10/01 - 2007/06/01 Postdoctoral Research Fellow Massachusetts General Hospital, Estados Unidos
2001/09/01 - 2004/11/04 PhD Student Whitehead Institute for Biomedical Research, Estados Unidos
1999/04/01 - 2001/09/01 PhD Student University of Chicago, Estados Unidos
1998/02/01 - 1998/09/03 Research training/internship University of Leeds, Reino Unido
Projetos

Bolsa

Designação Financiadores
2019/10 - Atual The role of lead exposure in the nervous system and Parkinson¿s disease onset and progression
SFRH/BD/143286/2019
Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal

Universitätsmedizin Göttingen Experimental Neurodegeneration, Alemanha

Lancaster University Department of Biological Sciences, Reino Unido
Fundação para a Ciência e a Tecnologia
Em curso
2011/09 - 2014/06 PARK- Identification of molecules to treat Parkinson´s Disease using a novel zebrafish model
Ref. 5553/4/Ae (acronym: PARK)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia

Eurostars
Concluído

Projeto

Designação Financiadores
2023/03/01 - 2024/08/31 Estudo do BUB1 em neurodesenvolvimento: identificação de novas funções Fundação para a Ciência e a Tecnologia
Em curso
2023/03/01 - 2024/08/31 Estudo do BUB1 em neurodesenvolvimento: identificação de novas funções Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2022/02/28 Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2022/02/28 Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2021/12/31 Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas
PTDC/MED-FAR/31323/2017
Instituto de Biologia Molecular e Celular, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016/06/01 - 2020/02/29 Defesas anti-glicação como alvo terapêutico para a doença de Parkinson
PTDC/NEU-OSD/5644/2014
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

iNOVA4Health, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2020/02/29 Defesas anti-glicação como alvo terapêutico para a doença de Parkinson
PTDC/NEU-OSD/5644/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

iNOVA4Health, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2020/02/29 Defesas anti-glicação como alvo terapêutico para a doença de Parkinson
PTDC/NEU-OSD/5644/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

iNOVA4Health, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2020/02/29 Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central
PTDC/BBB-NAN/1578/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2020/02/29 Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central
PTDC/BBB-NAN/1578/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2020/02/29 Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central
PTDC/BBB-NAN/1578/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2019/10/31 Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer
PTDC/QEQ-MED/5512/2014
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2019/10/31 Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer
PTDC/QEQ-MED/5512/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2019/10/31 Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer
PTDC/QEQ-MED/5512/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/03/01 - 2017/10/31 Avaliação Abrangente e Não Enviesada de Fatores de Risco Genéticos e Ambientais para a Doença de Parkinson
JPND-RF/0001/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/05/01 - 2015/10/31 Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador
PTDC/DTP-PIC/0904/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/05/01 - 2015/10/31 Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador
PTDC/DTP-PIC/0904/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/05/01 - 2015/10/31 Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador
PTDC/DTP-PIC/0904/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2014/05/31 Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson
EXPL/NEU-OSD/0606/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2014/05/31 Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson
EXPL/NEU-OSD/0606/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2014/05/31 Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson
EXPL/NEU-OSD/0606/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/05 - 2013/08/04 Análise das alterações da transcrição em modelos cerebrais e periféricos da doença de Huntington - influência da modulação das desacetilases das histonas
PTDC/SAU-FCF/108056/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/05 - 2013/07/31 Análise dos mecanismos moleculares que determinam disfunção da alfa-sinucleína e a citoxicidade na doença de Parkinson - o papel do GDNF
PTDC/SAU-NEU/101928/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/07/31 Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína
PTDC/SAU-NEU/105215/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/07/31 Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína
PTDC/SAU-NEU/105215/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/07/31 Modificação genética das células do núcleo paraventricular do hipotálamo (PVN) e medula rostroventrolateral (RVLM) para controlar cronicamente a hipertensão.
PTDC/SAU-OSM/109081/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/07/31 Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína
PTDC/SAU-NEU/105215/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/07/31 Modificação genética das células do núcleo paraventricular do hipotálamo (PVN) e medula rostroventrolateral (RVLM) para controlar cronicamente a hipertensão.
PTDC/SAU-OSM/109081/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide
PTDC/QUI-QUI/102049/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R
PTDC/SAU-GMG/099655/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide
PTDC/QUI-QUI/102049/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R
PTDC/SAU-GMG/099655/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide
PTDC/QUI-QUI/102049/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R
PTDC/SAU-GMG/099655/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/05 - 2013/05/31 Alteração do tráfego intracelular mediado pela mitocôndria na doença de Parkinson
PTDC/SAU-NEU/102710/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2013/02/17 Strategic Project - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2012/12/31 Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória
PTDC/SAU-NEU/099853/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2012/12/31 Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória
PTDC/SAU-NEU/099853/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2012/12/31 Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória
PTDC/SAU-NEU/099853/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/12/31 Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores
PIC/IC/82760/2007
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/12/31 Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores
PIC/IC/82760/2007
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/12/31 Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores
PIC/IC/82760/2007
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/01/02 - 2011/12/31 A glicação de proteínas e amiloidogenese da transtiretina em levedura: Um sistema modelo de doenças neurodegenerativas amiloidóticas
PTDC/QUI/70610/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/01/02 - 2011/12/31 A glicação de proteínas e amiloidogenese da transtiretina em levedura: Um sistema modelo de doenças neurodegenerativas amiloidóticas
PTDC/QUI/70610/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/01/01 - 2011/06/30 Efeito da glicação em proteínas chave da doença de Parkinson: estudos in vivo e in vitro dos mecanismos de folding, agregação e degradação da alfa-sinucleina, da sinfilina e da parkina em condições glicantes.
PTDC/QUI/73430/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/01/01 - 2011/06/30 Efeito da glicação em proteínas chave da doença de Parkinson: estudos in vivo e in vitro dos mecanismos de folding, agregação e degradação da alfa-sinucleina, da sinfilina e da parkina em condições glicantes.
PTDC/QUI/73430/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
1999/01/01 - 2002/12/31 AMYLOID FORMATION IN YEAST: COMPARATIVE STUDIES ON THE INFLUENCE OF CHAPERONES ON THE AGGREGATION PROCESS OF TRANSTHYRETIN AND OTHER AMYLOIDOGENIC PROTEINS
PRAXIS XXI/BD/18489/98
Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Grunho, Miguel; Godinho, Catarina; de Matos, António; Barroso, Helena; Carregosa, Ricardo; Marx, Frederico; Tomé, Morgane; et al. "Gut Status in Parkinson¿s Disease: The GutSPark Protocol". Trabalho apresentado em 5th International Congress of CiiEM, Almada, 2021.
    Publicado • 10.3390/msf2021005031
  2. Grunho, Miguel; Godinho, Catarina; Patita, Marta; Mocanu, Irina; Vieira, Ana; de Matos, António; Carregosa, Ricardo; et al. "Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson¿s Disease: The InflamaSPark Protocol". Trabalho apresentado em 5th International Congress of CiiEM, Almada, 2021.
    Publicado • 10.3390/msf2021005028
  3. Fernandes, J.T.S.; Tenreiro, S.; Pedrosa, C.R.; Gameiro, A.; Chu, V.; Outeiro, T.F.; Conde, J.P.. "Integration of single cell traps, chemical gradient generator and photosensors in a microfluidic platform for the study of alphasynuclein toxicity in yeast". 2014.
    10.1016/j.proeng.2014.11.273
Artigo em revista
  1. Felipe Saceanu Leser; Mirella Araújo Ribeiro; Lucas Dalsente Romano da Silva; Renato Garcia Domingues; Tiago Fleming Outeiro; Kevin Boyé; Eduardo Coelho Cerqueira; Fabiano Lacerda Carvalho; Phelippe do Carmo Gonçalves. "The relationship between anxiety and COVID-19-associated isolation and lifestyle changes in the university community as a result of the SARS-CoV-2 pandemic". Mental Health Science (2023): https://doi.org/10.1002/mhs2.48.
    10.1002/mhs2.48
  2. Tuane C. R. G. Vieira; Caroline A. Barros; Renato Domingues; Tiago Fleming Outeiro. "PrP meets alpha-synuclein: Molecular mechanisms and implications for disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15992.
    10.1111/jnc.15992
  3. Andrés D. Klein; Tiago Fleming Outeiro. "Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria". Nature Communications (2023): https://doi.org/10.1038/s41467-023-42107-7.
    10.1038/s41467-023-42107-7
  4. Daniel Oppermann Peixoto; Reykla Ramon Bittencourt; Juciano Gasparotto; Flávio Gabriel Carazza Kessler; Pedro Ozorio Brum; Nauana Somensi; Carolina Saibro Girardi; et al. "Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE)". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15956.
    10.1111/jnc.15956
  5. Manuel Flores-Leon; Tiago Fleming Outeiro. "More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy". Acta Neuropathologica (2023): https://doi.org/10.1007/s00401-023-02601-0.
    10.1007/s00401-023-02601-0
  6. Carmina C. Warth Perez Arias; Ivan Silbern; Lucas Caldi Gomes; Hannes Wartmann; Vivian Dambeck; Jonas Fanz; Lisa Neuenroth; et al. "Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15924.
    10.1111/jnc.15924
  7. Viviana Brembati; Gaia Faustini; Francesca Longhena; Tiago Fleming Outeiro; Arianna Bellucci. "Changes in a-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241713435.
    10.3390/ijms241713435
  8. Evelini Plácido; Priscilla Gomes Welter; Ana Wink; Gabriela Duarte Karasiak; Tiago Fleming Outeiro; Alcir Luiz Dafre; Joana Gil-Mohapel; Patricia S. Brocardo. "Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241612607.
    10.3390/ijms241612607
  9. Mario Habek; Antonela Blazekovic; Kristina Gotovac Jercic; Nela Pivac; Tiago Fleming Outero; Fran Borovecki; Vesna Brinar. "Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis". Biomedicines (2023): https://doi.org/10.3390/biomedicines11082209.
    10.3390/biomedicines11082209
  10. Avika Chopra; Tiago Fleming Outeiro. "Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies". Brain (2023): https://doi.org/10.1093/brain/awad260.
    10.1093/brain/awad260
  11. Tiago F. Outeiro; Tuane C. R. G. Vieira. "AI and protein structure and function in neurological disease: relevance to disease management". Nature Reviews Neurology (2023): https://doi.org/10.1038/s41582-023-00840-z.
    10.1038/s41582-023-00840-z
  12. Tiago F. Outeiro; Roy N. Alcalay; Angelo Antonini; Johannes Attems; Vincenzo Bonifati; Francisco Cardoso; Marie-Françoise Chesselet; et al. "Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”". Movement Disorders (2023): https://doi.org/10.1002/mds.29419.
    10.1002/mds.29419
  13. Juciano Gasparotto; Nauana Somensi; Carolina Saibro Girardi; Reykla Ramon Bittencourt; Laura Martinewski de Oliveira; Laura Piloneto Hoefel; Ingrid Matsubara Scheibel; et al. "Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15890.
    10.1111/jnc.15890
  14. Luisa Maria Gatzemeier; Franc Meyer; Ulf Diederichsen; Tiago Fleming Outeiro. "Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation". Chemistry – A European Journal (2023): https://doi.org/10.1002/chem.202300649.
    10.1002/chem.202300649
  15. Liana Shvachiy; Ângela Amaro-Leal; Tiago F. Outeiro; Isabel Rocha; Vera Geraldes. "Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation". Cells (2023): https://doi.org/10.3390/cells12050818.
    10.3390/cells12050818
  16. Luca Marsili; Jennifer Sharma; Tiago Fleming Outeiro; Carlo Colosimo. "Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials". Biomedicines (2023): https://doi.org/10.3390/biomedicines11020505.
    10.3390/biomedicines11020505
  17. Patrick W. Cullinane; Eduardo de Pablo Fernandez; Annekatrin König; Tiago Fleming Outeiro; Zane Jaunmuktane; Thomas T. Warner. "Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts". Movement Disorders (2023): https://doi.org/10.1002/mds.29298.
    10.1002/mds.29298
  18. Quesnel, Agathe; Coles, Nathan; Angione, Claudio; Dey, Priyanka; Polvikoski, Tuomo M.; Outeiro, Tiago F.; Islam, Meez; Khundakar, Ahmad A.; Filippou, Panagiota S.. "Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy". BMC Cancer (2023): https://publons.com/wos-op/publon/56741382/.
    10.1186/S12885-023-10588-W
  19. Hassanzadeh, Kambiz; Morrone, Castrese; Akhtari, Keivan; Gerhardt, Ellen; Zaccagnini, Ludovica; Outeiro, Tiago Fleming; Feligioni, Marco. "Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic". Mechanisms of Ageing and Development (2023): https://publons.com/wos-op/publon/56816349/.
    10.1016/J.MAD.2022.111759
  20. Outeiro, Tiago Fleming; El-Agnaf, Omar M.. "The immune system in Parkinson's disease: From biology to diagnosis and therapeutic targets". Neurobiology of Disease (2023): https://publons.com/wos-op/publon/56816365/.
    10.1016/J.NBD.2023.105995
  21. Aisha M. Swaih; Carlo Breda; Korrapati V. Sathyasaikumar; Natalie Allcock; Mary E. W. Collier; Robert P. Mason; Adam Feasby; et al. "Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane". Biomedicines (2022): https://doi.org/10.3390/biomedicines10092294.
    10.3390/biomedicines10092294
  22. Guaragnella, Nicoletta; Krisko, Anita; Outeiro, Tiago F.. "Editorial for the Special Issue "Adaptation, Aging, and Cell Death in Yeast Stress Response: Models, Mechanisms and Applications"". Microorganisms (2022): https://publons.com/wos-op/publon/55548779/.
    10.3390/MICROORGANISMS10061126
  23. Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago F.; Rocha, Isabel; Geraldes, Vera. "From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms". Biology (2022): https://publons.com/wos-op/publon/56816352/.
    10.3390/BIOLOGY11081164
  24. Lassen, Louise Berkhoudt; Thomsen, Maj Schneider; Basso, Elisa; Fuchtbauer, Ernst-Martin; Fuchtbauer, Annette; Outeiro, Tiago Fleming; Jensen, Poul Henning; Moos, Torben. "Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation". Cells (2022): https://publons.com/wos-op/publon/56543926/.
    10.3390/CELLS11223673
  25. Santos, Cleonice Creusa; Cardim-Pires, Thyago R.; Shvachiy, Liana; Fonseca-Fonseca, Luis Arturo; Munoz, Patricia; Almeida, Aurea Maria A. N.; Costa, Ana Carla S.; et al. "JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species". Neurotoxicity Research (2022): https://publons.com/wos-op/publon/55404800/.
    10.1007/S12640-022-00559-7
  26. Bras, Ines C.; Khani, Mohammad H.; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; van Riesen, Christoph; Urlaub, Henning; Gollisch, Tim; Outeiro, Tiago F.. "Ectosomes and exosomes modulate neuronal spontaneous activity". Journal of Proteomics (2022): https://publons.com/wos-op/publon/56816350/.
    10.1016/J.JPROT.2022.104721
  27. Vasili, Eftychia; Dominguez-Meijide, Antonio; Flores-Leon, Manuel; Al-Azzani, Mohammed; Kanellidi, Angeliki; Melki, Ronald; Stefanis, Leonidas; Outeiro, Tiago Fleming. "Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells". Molecular Neurobiology (2022): https://publons.com/wos-op/publon/52531699/.
    10.1007/S12035-021-02713-2
  28. Ghanem, Simona S.; Majbour, Nour K.; Vaikath, Nishant N.; Ardah, Mustafa T.; Erskine, Daniel; Jensen, Nanna Moller; Fayyad, Muneera; et al. "alpha-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity". Proceedings of the National Academy of Sciences (2022): https://publons.com/wos-op/publon/55106406/.
    10.1073/PNAS.2109617119
  29. Bras, Ines C.; Khani, Mohammad H.; Vasili, Eftychia; Moebius, Wiebke; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; et al. "Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity". Journal of Parkinson's Disease (2022): https://publons.com/wos-op/publon/56816361/.
    10.3233/JPD-223516
  30. Jost, Wolfgang H.; Buhmann, Carsten; Classen, Joseph; Eggert, Karla; Kohl, Zacharias; Outeiro, Tiago; Tonges, Lars; Woitalla, Dirk; Reichmann, Heinz. "Relevance of COMT inhibitors in the treatment of motor fluctuations". Der Nervenarzt (2022): https://publons.com/wos-op/publon/56816360/.
    10.1007/S00115-021-01237-3
  31. Koss, David J.; Erskine, Daniel; Porter, Andrew; Palmoski, Pawel; Menon, Hariharan; Todd, Olivia G. J.; Leite, Marta; Attems, Johannes; Outeiro, Tiago F.. "Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies". Acta Neuropathologica Communications (2022): https://publons.com/wos-op/publon/56816353/.
    10.1186/S40478-022-01403-X
  32. Cassotta, Manuela; Geerts, Hugo; Harbom, Lise; Outeiro, Tiago F.; Pediaditakis, Iosif; Reiner, Orly; Schildknecht, Stefan; et al. "The Future of Parkinson?s Disease Research A New Paradigm of Human Specific Investigation Is Necessary ... and Possible ...". ALTEX (2022): https://publons.com/wos-op/publon/56816358/.
    10.14573/ALTEX.2203161
  33. Torres-Garcia, Laura; P. Domingues, Joana M.; Brandi, Edoardo; Haikal, Caroline; Mudannayake, Janitha M.; Bras, Ines C.; Gerhardt, Ellen; et al. "Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation". Scientific Reports (2022): https://publons.com/wos-op/publon/53553098/.
    10.1038/S41598-022-06846-9
  34. Buratti, Fiamma A.; Boeffinger, Nicola; Garro, Hugo A.; Flores, Jesica S.; Hita, Francisco J.; do Carmo Goncalves, Phelippe; dos Reis Copello, Federico; et al. "Aromaticity at position 39 in alpha-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations". Protein Science (2022): https://publons.com/wos-op/publon/56816355/.
    10.1002/PRO.4360
  35. Jordan, Kate L.; Koss, David J.; Outeiro, Tiago F.; Giorgini, Flaviano. "Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease". Biomedicines (2022): https://publons.com/wos-op/publon/56816356/.
    10.3390/BIOMEDICINES10051141
  36. Chegao, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido-Ferreira, Mariana; Marques-Morgado, Ines; Fernandes Gomes, Barbara; et al. "Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes". Npj Parkinson's Disease (2022): https://publons.com/wos-op/publon/52342419/.
    10.1038/S41531-022-00314-X
  37. Shaib, A. H.; Chouaib, A. A.; Imani, V.; Chowdhury, R.; Georgiev, S. V.; Mougios, N.; Monga, M.; et al. "Expansion microscopy at one nanometer resolution". BioRxiv (2022): https://publons.com/wos-op/publon/56816351/.
    10.1101/2022.08.03.502284
  38. Al-Azzani, Mohammed; Koenig, Annekatrin; Outeiro, Tiago Fleming. "Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight". Biomolecules (2022): https://publons.com/wos-op/publon/50786423/.
    10.3390/BIOM12020324
  39. Hatton, Christopher; Ghanem, Simona S.; Koss, David J.; Abdi, Ilham Y.; Gibbons, Elizabeth; Guerreiro, Rita; Bras, Jose; et al. "Prion-like a-synuclein pathology in the brain of infants with Krabbe disease". Brain (2022): https://publons.com/wos-op/publon/56816369/.
    10.1093/BRAIN/AWAC002
  40. Schaffner, Samantha L.; Wassouf, Zinah; Lazaro, Diana F.; Xylaki, Mary; Gladish, Nicole; Lin, David T. S.; MacIsaac, Julia; et al. "Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways". Human Molecular Genetics (2022): https://publons.com/wos-op/publon/56816368/.
    10.1093/HMG/DDAC104
  41. Thom, Tobias; Schmitz, Matthias; Fischer, Anna-Lisa; Correia, Angela; Correia, Susana; Llorens, Franc; Pique, Anna-Villar; et al. "Cellular Prion Protein Mediates alpha-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo". Movement Disorders (2022): https://publons.com/wos-op/publon/49855476/.
    10.1002/MDS.28774
  42. Domingues, Renato; Sant'Anna, Ricardo; Carvalho da Fonseca, Anna Carolina; Robbs, Bruno K.; Foguel, Debora; Outeiro, Tiago F.. "Extracellular alpha-synuclein: Sensors, receptors, and responses". Neurobiology of Disease (2022): https://publons.com/wos-op/publon/51840010/.
    10.1016/J.NBD.2022.105696
  43. Magalhaes, Rayne S. S.; Boechat, Fernanda C.; Brasil, Aline A.; Neto, Jose R. M.; Ribeiro, Gabriela D.; Paranhos, Luan H.; de Souza, Natalia Neves; et al. "Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1". Journal of Cellular Biochemistry (2022): https://publons.com/wos-op/publon/56816367/.
    10.1002/JCB.30317
  44. Queiroz, Daniela D.; Ribeiro, Thales de P.; Goncalves, Julliana M.; Mattos, Larissa M. M.; Gerhardt, Ellen; Freitas, Julia; Palhano, Fernando L.; et al. "A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2022): https://publons.com/wos-op/publon/54121415/.
    10.1016/J.BBADIS.2022.166475
  45. Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago; Geraldes, Vera. "Behavioral and molecular changes resulted from different environmental lead exposures: a comparative study". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/56816366/.
  46. Pena-Diaz, Samuel; Pujols, Jordi; Vasili, Eftychia; Pinheiro, Francisca; Santos, Jaime; Manglano-Artunedo, Zoe; Outeiro, Tiago F.; Ventura, Salvador. "The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple alpha-synuclein strains". Journal of Biological Chemistry (2022): https://publons.com/wos-op/publon/54454954/.
    10.1016/J.JBC.2022.101902
  47. Rita Rosado-Ramos; Joana Godinho-Pereira; Daniela Marques; Inês Figueira; Tiago Fleming Outeiro; Regina Menezes; Cláudia Nunes dos Santos. "Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation". Molecules (2021): https://doi.org/10.3390/molecules26113353.
    10.3390/molecules26113353
  48. Tiago Fleming Outeiro. "Emerging concepts in synucleinopathies". Acta Neuropathologica (2021): https://doi.org/10.1007/s00401-021-02290-7.
    10.1007/s00401-021-02290-7
  49. Inês C. Brás; Tiago F. Outeiro. "Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies". Cells 10 2 (2021): 375-375. https://doi.org/10.3390/cells10020375.
    10.3390/cells10020375
  50. Tiago F. Outeiro; Anita Krisko. "Reply to: “Parkinson's Disease and COVID-19: Do We Need to Be More Patient?”". Movement Disorders (2021): https://doi.org/10.1002/mds.28482.
    10.1002/mds.28482
  51. David J. Koss; Odeta Bondarevaite; Sara Adams; Marta Leite; Flaviano Giorgini; Johannes Attems; Tiago F. Outeiro. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aß plaques and Lewy bodies". Brain Pathology (2021): https://doi.org/10.1111/bpa.12890.
    10.1111/bpa.12890
  52. Tiago Fleming Outeiro. "Alpha-Synuclein Antibody Characterization: Why Semantics Matters". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02269-7.
    10.1007/s12035-020-02269-7
  53. Koss, David J.; Bondarevaite, Odeta; Adams, Sara; Leite, Marta; Giorgini, Flaviano; Attems, Johannes; Outeiro, Tiago F.. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within a beta plaques and Lewy bodies". Brain Pathology (2021): https://publons.com/publon/32062536/.
    10.1111/BPA.12890
  54. Medina, Luciana; Gonzalez-Lizarraga, Florencia; Dominguez-Meijide, Antonio; Ploper, Diego; Parrales, Valeria; Sequeira, Sabrina; Cima-Omori, Maria-Sol; et al. "Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity". Frontiers in Aging Neuroscience (2021): https://publons.com/wos-op/publon/34409849/.
    10.3389/FNAGI.2021.635760
  55. Schaffner, S. L.; Wassouf, Z.; Lazaro, D. F.; Xylaki, M.; Gladish, N.; Lin, D. T. S.; MacIsaac, J.; et al. "Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways". BioRxiv (2021): https://publons.com/wos-op/publon/56816363/.
    10.1101/2021.06.12.448150
  56. Flores-Leon, Manuel; Lazaro, Diana F.; Shvachiy, Liana; Krisko, Anita; Outeiro, Tiago F.. "In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2021): https://publons.com/wos-op/publon/56816364/.
    10.1016/J.BBAPAP.2021.140693
  57. Popova, Blagovesta; Wang, Dan; Paetz, Christina; Akkermann, Dagmar; Lazaro, Diana F.; Galka, Dajana; Kolog Gulko, Miriam; et al. "DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of alpha-synuclein toxicity and oligomerization". PLOS Genetics (2021): https://publons.com/wos-op/publon/35817065/.
    10.1371/JOURNAL.PGEN.1009407
  58. Jacinto, Sandra; Guerreiro, Patricia; de Oliveira, Rita Machado; Cunha-Oliveira, Teresa; Santos, Maria Joao; Grazina, Manuela; Rego, Ana Cristina; Outeiro, Tiago F.. "MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile". Frontiers in Cellular Neuroscience (2021): https://publons.com/wos-op/publon/30853828/.
    10.3389/FNCEL.2021.641264
  59. Erskine, Daniel; Koss, David; Walker, Lauren; Outeiro, Tiago; Attems, Johannes. "Lipid metabolism alterations are associated with alpha-synuclein pathology in Lewy body dementia". Neuropathology and Applied Neurobiology (2021): https://publons.com/wos-op/publon/48287854/.
  60. Popova, Blagovesta; Wang, Dan; Rajavel, Abirami; Dhamotharan, Karthikeyan; Lazaro, Diana F.; Gerke, Jennifer; Uhrig, Joachim F.; et al. "Identification of Two Novel Peptides That Inhibit alpha-Synuclein Toxicity and Aggregation". Frontiers in Molecular Neuroscience (2021): https://publons.com/wos-op/publon/46047996/.
    10.3389/FNMOL.2021.659926
  61. Oliveira, Luis M. A.; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal A.; et al. "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease". Npj Parkinson's Disease (2021): https://publons.com/wos-op/publon/49756374/.
    10.1038/S41531-021-00203-9
  62. Wong-Guerra, Maylin; Montano-Peguero, Yanay; Ramirez-Sanchez, Jeney; Jimenez-Martin, Javier; Arturo Fonseca-Fonseca, Luis; Hernandez-Ensenat, Daniela; Nonose, Yasmine; et al. "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats". NeuroToxicology (2021): https://publons.com/wos-op/publon/49349605/.
    10.1016/J.NEURO.2021.08.017
  63. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): https://publons.com/wos-op/publon/34779767/.
    10.1080/15548627.2020.1797280
  64. Koss, David J.; Campesan, Susanna; Giorgini, Flaviano; Outeiro, Tiago F.. "Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases". Movement Disorders (2021): https://publons.com/wos-op/publon/46254551/.
    10.1002/MDS.28605
  65. Dominguez-Meijide, Antonio; Parrales, Valeria; Vasili, Eftychia; Gonzalez-Lizarraga, Florencia; Konig, Annekatrin; Lazaro, Diana F.; Lannuzel, Annie; et al. "Doxycycline inhibits alpha -synuclein-associated pathologies in vitro and in vivo". Neurobiology of Disease (2021): https://publons.com/wos-op/publon/36312904/.
    10.1016/J.NBD.2021.105256
  66. Miranda, Hugo Vicente; Szego, Eva M.; Oliveira, Luis M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. "Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies (vol 140, pg 1399, 2017)". Brain (2021): https://publons.com/wos-op/publon/50474925/.
    10.1093/BRAIN/AWAB175
  67. Hatton, C.; Ghanem, S. S.; Koss, D. J.; Abdi, I. Y.; Gibbons, E.; Guerreiro, R.; Bras, J.; et al. "Prion-like α-synuclein pathology in the brains of infants: Krabbe disease as a novel seed-competent α-synucleinopathy". BioRxiv (2021): https://publons.com/wos-op/publon/56816359/.
    10.1101/2021.10.12.463948
  68. Erskine, Daniel; Koss, David; Korolchuk, Viktor I.; Outeiro, Tiago F.; Attems, Johannes; McKeith, Ian. "Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders". Acta Neuropathologica (2021): https://publons.com/wos-op/publon/40156393/.
    10.1007/S00401-021-02266-7
  69. Albert, Katrina; Raymundo, Diana P.; Panhelainen, Anne; Eesmaa, Ave; Shvachiy, Liana; Araujo, Gabriela R.; Chmielarz, Piotr; et al. "Cerebral dopamine neurotrophic factor reduces a-synuclein aggregation and propagation and alleviates behavioral alterations in vivo". Molecular Therapy (2021): https://publons.com/wos-op/publon/50745970/.
    10.1016/J.YMTHE.2021.04.035
  70. Arturo Fonseca-Fonseca, Luis; Amaral da Silva, Victor Diogenes; Wong-Guerra, Maylin; Ramirez-Sanchez, Jeney; Padron Yaquis, Alejandro Saul; Ochoa-Rodriguez, Estael; Verdecia-Reyes, Yamila; et al. "JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties". NeuroToxicology (2021): https://publons.com/wos-op/publon/40154015/.
    10.1016/J.NEURO.2020.11.005
  71. Patrícia I. Santos; Tiago F. Outeiro. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal (2020): https://doi.org/10.1111/febs.15364.
    10.1111/febs.15364
  72. Panagiota S. Filippou; Tiago F. Outeiro. "Cancer and Parkinson's Disease: Common Targets, Emerging Hopes". Movement Disorders (2020): https://doi.org/10.1002/mds.28425.
    10.1002/mds.28425
  73. Tiago Fleming Outeiro. "Alpha-synuclein oligomerization and aggregation: a model will always be a model". Journal of Neurochemistry (2020): https://doi.org/10.1111/jnc.15264.
    10.1111/jnc.15264
  74. Tiago F. Outeiro; Peter Heutink; Erwan Bezard; Angela M. Cenci. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders (2020): https://doi.org/10.1002/mds.28387.
    10.1002/mds.28387
  75. Antonio Dominguez-Meijide; Eftychia Vasili; Tiago Fleming Outeiro. "Pharmacological Modulators of Tau Aggregation and Spreading". Brain Sciences (2020): https://doi.org/10.3390/brainsci10110858.
    10.3390/brainsci10110858
  76. Tiago F. Outeiro; Anita Krisko. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders (2020): https://doi.org/10.1002/mds.28178.
    10.1002/mds.28178
  77. Alice Lippi; Renato Domingues; Cristian Setz; Tiago F. Outeiro; Anita Krisko. "SARS-CoV -2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders (2020): https://doi.org/10.1002/mds.28084.
    10.1002/mds.28084
  78. Leonor Correia Guedes; Tiago Mestre; Tiago F. Outeiro; Joaquim J. Ferreira. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry 152 5 (2020): 515-522. https://doi.org/10.1111/jnc.14902.
    10.1111/jnc.14902
  79. Tiago Fleming Outeiro. "The courage to change science". EMBO reports 21 3 (2020): https://doi.org/10.15252/embr.202050124.
    10.15252/embr.202050124
  80. Inês Caldeira Brás; Antonio Dominguez-Meijide; Ellen Gerhardt; David Koss; Diana F. Lázaro; Patrícia I. Santos; Eftychia Vasili; Mary Xylaki; Tiago Fleming Outeiro. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry (2020): https://doi.org/10.1111/jnc.14965.
    10.1111/jnc.14965
  81. Rita L. Vaz; Diana Chapela; Joana E. Coelho; Luísa V. Lopes; Joaquim J. Ferreira; Nuno D. Afonso; Sara Sousa; Tiago F. Outeiro. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience 424 (2020): 58-71. https://doi.org/10.1016/j.neuroscience.2019.08.046.
    10.1016/j.neuroscience.2019.08.046
  82. Vaz, R.L.; Sousa, S.; Chapela, D.; van der Linde, H.C.; Willemsen, R.; Correia, A.D.; Outeiro, T.F.; Afonso, N.D.. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology Biochemistry and Behavior 189 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076900575&partnerID=MN8TOARS.
    10.1016/j.pbb.2019.172828
  83. Masaracchia, C.; König, A.; Valiente-Gabioud, A.A.; Peralta, P.; Favretto, F.; Strohäker, T.; Lázaro, D.F.; et al. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta - Proteins and Proteomics 1868 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074345130&partnerID=MN8TOARS.
    10.1016/j.bbapap.2019.140298
  84. Lázaro, D.F.; Bellucci, A.; Brundin, P.; Outeiro, T.F.. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience 12 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078861604&partnerID=MN8TOARS.
    10.3389/fnmol.2019.00312
  85. Vale, N.; Alves, C.; Sharma, V.; Lázaro, D.F.; Silva, S.; Gomes, P.; Outeiro, T.F.. "A new MAP-Rasagiline conjugate reduces a-synuclein inclusion formation in a cell model". Pharmacological Reports (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079598813&partnerID=MN8TOARS.
    10.1007/s43440-019-00032-x
  86. Belo, Rita F.; Martins, Margarida L.F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". (2020): http://hdl.handle.net/10362/101849.
    https://doi.org/10.3389/fphar.2020.00985
  87. Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Inês; Garcia, Gonçalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". (2020): http://hdl.handle.net/10362/105560.
    https://doi.org/10.3390/antiox9090789
  88. Vaz, Rita L.; Chapela, Diana; Coelho, Joana E.; Lopes, Luisa, V; Ferreira, Joaquim J.; Afonso, Nuno D.; Sousa, Sara; Outeiro, Tiago F.. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience (2020): https://publons.com/publon/36281139/.
    10.1016/J.NEUROSCIENCE.2019.08.046
  89. Guedes, Leonor Correia; Mestre, Tiago; Outeiro, Tiago F.; Ferreira, Joaquim J.. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry (2020): https://publons.com/publon/28545540/.
    10.1111/JNC.14902
  90. Vaz, Rita L.; Sousa, Sara; Chapela, Diana; van der Linde, Hernia C.; Willemsen, Rob; Correia, Ana D.; Outeiro, Tiago F.; Afonso, Nuno D.. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology, Biochemistry and Behavior (2020): https://publons.com/publon/36281134/.
    10.1016/J.PBB.2019.172828
  91. Lazaro, Diana F.; Bellucci, Arianna; Brundin, Patrik; Outeiro, Tiago F.. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience (2020): https://publons.com/publon/36281135/.
    10.3389/FNMOL.2019.00312
  92. Masaracchia, Caterina; Koenig, Annekatrin; Valiente-Gabioud, Ariel A.; Peralta, Pablo; Favretto, Filippo; Strohaeker, Timo; Lazaro, Diana F.; et al. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2020): https://publons.com/publon/36281137/.
    10.1016/J.BBAPAP.2019.140298
  93. Malik, Nauman; Miah, Mohi; McAleese, Kirsty; Outeiro, Tiago; Thomas, Alan; Koss, David J.. "Contribution of amyloid and tau white matter pathology to the spatial spread of Alzheimer's disease pathology". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281129/.
  94. Placido, E.; Koss, D. J.; Brocardo, P. S.; Outeiro, T. F.. "Cell proliferation and differentiation in Parkinson's disease". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281130/.
  95. Bras, Ines Caldeira; Dominguez-Meijide, Antonio; Gerhardt, Ellen; Koss, David; Lazaro, Diana F.; Santos, Patricia, I; Vasili, Eftychia; Xylaki, Mary; Outeiro, Tiago Fleming. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry (2020): https://publons.com/publon/27892701/.
    10.1111/JNC.14965
  96. Outeiro, Tiago Fleming. "The courage to change science". EMBO Reports (2020): https://publons.com/publon/36281131/.
    10.15252/EMBR.202050124
  97. Lazaro, Diana F.; Outeiro, Tiago F.. "The Interplay Between Proteostasis Systems and Parkinson's Disease". Advances in Experimental Medicine and Biology (2020): https://publons.com/publon/36281141/.
    10.1007/978-3-030-38266-7_9
  98. Outeiro, Tiago. "Effects of pharmacological modulators of alpha-synuclein and tau aggregation and internalization". Scientific Reports (2020): https://publons.com/publon/36281118/.
    10.1038/S41598-020-69744-Y
  99. Torres, C. Alejandra Morato; Wassouf, Zinah; Zafar, Faria; Sastre, Danuta; Outeiro, Tiago Fleming; Schule, Birgitt. "The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders". International Journal of Molecular Sciences (2020): https://publons.com/publon/36281117/.
    10.3390/IJMS21165724
  100. Outeiro, Tiago. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders (2020): https://publons.com/publon/36281119/.
    10.1002/mds.28178
  101. Domingues, Renato; Lippi, Alice; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. "SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime". Aging (2020): https://publons.com/publon/34388968/.
    10.18632/AGING.103989
  102. Temido-Ferreira, Mariana; Ferreira, Diana G.; Batalha, Vsnia L.; Marques-Morgado, Ines; Coelho, Joana E.; Pereira, Pedro; Gomes, Rui; et al. "Age-related shift in LTD is dependent on neuronal adenosine A(2A)receptors interplay with mGluR5 and NMDA receptors". Molecular Psychiatry (2020): https://publons.com/publon/17854214/.
    10.1038/S41380-018-0110-9
  103. Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, Joao; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid beta Peptide-Induced Alzheimer's Disease Pathophysiology". Frontiers in Pharmacology (2020): https://publons.com/publon/33896655/.
    10.3389/FPHAR.2020.00985
  104. Vale, Nuno; Alves, Claudia; Sharma, Vaishali; Lazaro, Diana F.; Silva, Sara; Gomes, Paula; Outeiro, Tiago Fleming. "A new MAP-Rasagiline conjugate reduces alpha-synuclein inclusion formation in a cell model". Pharmacological Reports (2020): https://publons.com/publon/36281124/.
    10.1007/S43440-019-00032-X
  105. Miranda, Hugo Vicente; Chegao, Ana; Oliveira, Marcia S.; Gomes, Barbara Fernandes; Enguita, Francisco J.; Outeiro, Tiago Fleming. "Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein". The FASEB Journal (2020): https://publons.com/publon/33896656/.
    10.1096/FJ.201902936R
  106. Koss, D. J.; Erskine, D.; Attems, J.; Outeiro, T.. "Resolving the issue of nuclear localisation of alpha-synuclein in Lewy body diseases". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281127/.
  107. Koss, D. J.; Bondarevaite, O.; Adams, S.; Leite, M.; Attems, J.; Giorgini, F.; Outeiro, T.. "Determination of the pathological involvement of the vesicular trafficking protein RAB39B in idiopathic variants of neurodegenerative disease". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281128/.
  108. Lippi, Alice; Domingues, Renato; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. "SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders (2020): https://publons.com/publon/32314223/.
    10.1002/MDS.2808410.1002/MDS.28084
  109. Santos, Patricia, I; Outeiro, Tiago F.. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal (2020): https://publons.com/publon/31041262/.
    10.1111/FEBS.15364
  110. Francelle, Laetitia; Outeiro, Tiago F.; Rappold, Gudrun A.. "Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity". Scientific Reports (2020): https://publons.com/publon/36281121/.
    10.1038/S41598-020-62678-5
  111. Lippi, Alice; Domingues, Renato; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. "SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders (2020): https://publons.com/publon/31478768/.
    10.1002/MDS.28084
  112. Outeiro, Tiago F.; Heutink, Peter; Bezard, Erwan; Cenci, Angela M.. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders (2020): https://publons.com/publon/36281114/.
    10.1002/MDS.28387
  113. Hentrich, Thomas; Wassouf, Zinah; Ehrhardt, Christine; Haas, Eva; Mills, James D.; Aronica, Eleonora; Outeiro, Tiago Fleming; et al. "Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients". Aging (2020): https://publons.com/publon/36281116/.
    10.18632/AGING.103935
  114. Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Ines; Garcia, Goncalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". Antioxidants (2020): https://publons.com/publon/33378118/.
    10.3390/ANTIOX9090789
  115. Filippou, PanagiotaS.; Outeiro, Tiago F.. "Cancer and Parkinson's Disease: Common Targets, Emerging Hopes". Movement Disorders (2020): https://publons.com/publon/36281112/.
    10.1002/MDS.28425
  116. Cukierman, Daphne S.; Lazaro, Diana F.; Sacco, Pamela; Ferreira, Patricia R.; Diniz, Renata; Fernandez, Claudio O.; Outeiro, Tiago F.; Rey, Nicolas A.. "X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-alpha-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy". Dalton Transactions (2020): https://publons.com/publon/36281113/.
    10.1039/D0DT01138J
  117. Dominguez-Meijide, Antonio; Vasili, Eftychia; Outeiro, Tiago Fleming. "Pharmacological Modulators of Tau Aggregation and Spreading". Brain Sciences (2020): https://publons.com/publon/36281115/.
    10.3390/BRAINSCI10110858
  118. Erskine, D.; Majbour, N.; Kauser, M.; Xylaki, M.; Attems, J.; Outeiro, T.; El-Agnaf, O.. "Regionally different expression of a novel alpha-synuclein species between Parkinson's disease dementia and dementia with Lewy bodies". Neuropathology and Applied Neurobiology (2020): https://publons.com/wos-op/publon/48287841/.
  119. Tiago Fleming Outeiro; David J. Koss; Daniel Erskine; Lauren Walker; Marzena Kurzawa-Akanbi; David Burn; Paul Donaghy; et al. "Dementia with Lewy bodies: an update and outlook". Molecular Neurodegeneration 14 1 (2019): https://doi.org/10.1186/s13024-019-0306-8.
    10.1186/s13024-019-0306-8
  120. Marion Delenclos; Jeremy D. Burgess; Agaristi Lamprokostopoulou; Tiago F. Outeiro; Kostas Vekrellis; Pamela J. McLean. "Cellular models of alpha-synuclein toxicity and aggregation". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14806.
    10.1111/jnc.14806
  121. Amir Tayaranian Marvian; David J. Koss; Farhang Aliakbari; Dina Morshedi; Tiago Fleming Outeiro. "In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14707.
    10.1111/jnc.14707
  122. Nazareno González; Trinidad Arcos-López; Annekatrin König; Liliana Quintanar; Mauricio Menacho Márquez; Tiago F. Outeiro; Claudio O. Fernández. "Effects of alpha-synuclein post-translational modifications on metal binding". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14721.
    10.1111/jnc.14721
  123. Tiago Fleming Outeiro; Tiago A. Mestre. "Synuclein Meeting 2019: where we are and where we need to go". Journal of Neurochemistry 150 5 (2019): 462-466. https://doi.org/10.1111/jnc.14825.
    10.1111/jnc.14825
  124. Tiago Fleming Outeiro; Kirsten Harvey; Antonio Dominguez-Meijide; Ellen Gerhardt. "LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?". Biochemical Society Transactions 47 3 (2019): 827-838. https://doi.org/10.1042/BST20180466.
    10.1042/BST20180466
  125. Jing Gong; Éva M. Szego; Andrei Leonov; Eva Benito; Stefan Becker; Andre Fischer; Markus Zweckstetter; Tiago Outeiro; Anja Schneider. "Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism". The Journal of Neuroscience (2019): 2070-18. https://doi.org/10.1523/JNEUROSCI.2070-18.2019.
    10.1523/JNEUROSCI.2070-18.2019
  126. Prasad, V.; Wasser, Y.; Hans, F.; Goswami, A.; Katona, I.; Outeiro, T.F.; Kahle, P.J.; Schulz, J.B.; Voigt, A.. "Monitoring a-synuclein multimerization in vivo". FASEB Journal 33 2 (2019): 2116-2131. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061044826&partnerID=MN8TOARS.
    10.1096/fj.201800148RRR
  127. Szego, É.M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D.J.; Li, W.; Pinho, R.; et al. "Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies". Cell Reports 28 1 (2019): 65-77.e6. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067867617&partnerID=MN8TOARS.
    10.1016/j.celrep.2019.06.009
  128. Rossetti, G.; Kless, A.; Lai, L.; Outeiro, T.F.; Carloni, P.. "Investigating targets for neuropharmacological intervention by molecular dynamics simulations". Biochemical Society Transactions 47 3 (2019): 909-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069234924&partnerID=MN8TOARS.
    10.1042/BST20190048
  129. Brás, I.C.; König, A.; Outeiro, T.F.. "Glycation in Huntington's disease: A possible modifier and target for intervention". Journal of Huntington's Disease 8 3 (2019): 245-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071690821&partnerID=MN8TOARS.
    10.3233/JHD-190366
  130. Paiva, I.; Carvalho, K.; Santos, P.; Cellai, L.; Pavlou, M.A.S.; Jain, G.; Gnad, T.; et al. "A2AR-induced transcriptional deregulation in astrocytes: An in vitro study". GLIA 67 12 (2019): 2329-2342. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069928306&partnerID=MN8TOARS.
    10.1002/glia.23688
  131. Xylaki, M.; Atzler, B.; Outeiro, T.F.. "Epigenetics of the Synapse in Neurodegeneration". Current Neurology and Neuroscience Reports 19 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071147790&partnerID=MN8TOARS.
    10.1007/s11910-019-0995-y
  132. Chiang, A.N.; Liang, M.; Dominguez-Meijide, A.; Masaracchia, C.; Goeckeler-Fried, J.L.; Mazzone, C.S.; Newhouse, D.W.; et al. "Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding". Bioorganic and Medicinal Chemistry 27 1 (2019): 79-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057777957&partnerID=MN8TOARS.
    10.1016/j.bmc.2018.11.011
  133. Ferreira, C.; Couceiro, J.; Família, C.; Jardim, C.; Antas, P.; Santos, C.N.; Outeiro, T.F.; Tenreiro, S.; Quintas, A.. "The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism". FEMS Yeast Research 19 5 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071586602&partnerID=MN8TOARS.
    10.1093/femsyr/foz042
  134. de Araújo Brasil, A.; de Carvalho, M.D.C.; Gerhardt, E.; Queiroz, D.D.; Pereira, M.D.; Outeiro, T.F.; Eleutherio, E.C.A.. "Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1". Proceedings of the National Academy of Sciences of the United States of America 116 51 (2019): 25991-26000. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076710275&partnerID=MN8TOARS.
    10.1073/pnas.1902483116
  135. Vasili, E.; Dominguez-Meijide, A.; Outeiro, T.F.. "Spreading of a-synuclein and tau: A systematic comparison of the mechanisms involved". Frontiers in Molecular Neuroscience 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066921788&partnerID=MN8TOARS.
    10.3389/fnmol.2019.00107
  136. Wu, J.-Z.; Ardah, M.; Haikal, C.; Svanbergsson, A.; Diepenbroek, M.; Vaikath, N.N.; Li, W.; et al. "Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy". Translational Neurodegeneration 8 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067310536&partnerID=MN8TOARS.
    10.1186/s40035-019-0159-7
  137. Repici, M.; Hassanjani, M.; Maddison, D.C.; Garção, P.; Cimini, S.; Patel, B.; Szegö, É.M.; et al. "The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration". Molecular Neurobiology 56 1 (2019): 61-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045734709&partnerID=MN8TOARS.
    10.1007/s12035-018-1084-y
  138. Pinho, R.; Wang, B.; Becker, A.; Rothenberger, A.; Outeiro, T.F.; Herrmann-Lingen, C.; Meyer, T.. "Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study". World Journal of Biological Psychiatry 20 6 (2019): 496-504. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043378505&partnerID=MN8TOARS.
    10.1080/15622975.2017.1417636
  139. Carija, A.; Pinheiro, F.; Pujols, J.; Brás, I.C.; Lázaro, D.F.; Santambrogio, C.; Grandori, R.; et al. "Biasing the native a-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity". Redox Biology 22 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85061342548&partnerID=MN8TOARS.
    10.1016/j.redox.2019.101135
  140. Candelise, N.; Schmitz, M.; Llorens, F.; Villar-Piqué, A.; Cramm, M.; Thom, T.; da Silva Correia, S.M.; et al. "Seeding variability of different alpha synuclein strains in synucleinopathies". Annals of Neurology 85 5 (2019): 691-703. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063529329&partnerID=MN8TOARS.
    10.1002/ana.25446
  141. Sampaio-Marques, B.; Guedes, A.; Vasilevskiy, I.; Gonçalves, S.; Outeiro, T.F.; Winderickx, J.; Burhans, W.C.; Ludovico, P.. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". Aging Cell 18 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068785880&partnerID=MN8TOARS.
    10.1111/acel.12922
  142. Pinho, R.; Paiva, I.; Jercic, K.G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C.; Garcia-Esparcia, P.; et al. "Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein". Human Molecular Genetics 28 1 (2019): 31-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058740345&partnerID=MN8TOARS.
    10.1093/hmg/ddy326
  143. Sampaio-Marques, Belém; Guedes, Ana; Vasilevskiy, Igor; Gonçalves, Susana; Outeiro, Tiago F.; Winderickx, Joris; Burhans, William C.; Ludovico, Paula. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". (2019): http://www.scopus.com/inward/record.url?scp=85068785880&partnerID=8YFLogxK.
    https://doi.org/10.1111/acel.12922
  144. Marques, Maria Belém Sousa Sampaio; Guedes, Ana; Vasilevskiy, Igor; Gonçalves, Susana; Outeiro, Tiago F.; Winderickx, Joris; Burhans, William C.; Ludovico, Paula. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". (2019): http://hdl.handle.net/1822/62310.
    10.1111/acel.12922
  145. Barcelos, Tiago Soares; Carvalho, Marina de Macedo; Outeiro, Gabriel Moraes de; Mota, Loyslene de Freitas. "Interdisciplinary analysis of the mineral question and its reject barrings". (2019): http://www.periodicos.unc.br/index.php/drd/article/view/2091.
  146. Brown, Peter; Tan, Aik-Choon; El-Esawi, Mohamed A.; Liehr, Thomas; Blanck, Oliver; Gladue, Douglas P.; Almeida, Gabriel M. F.; et al. "Large expert-curated database for benchmarking document similarity detection in biomedical literature search". Database (2019): https://publons.com/publon/24451107/.
    10.1093/DATABASE/BAZ085
  147. Outeiro, Tiago Fleming; Mestre, Tiago A.. "Synuclein Meeting 2019: where we are and where we need to go". Journal of Neurochemistry (2019): https://publons.com/publon/36281143/.
    10.1111/JNC.14825
  148. Xylaki, Mary; Atzler, Benedict; Outeiro, Tiago Fleming. "Epigenetics of the Synapse in Neurodegeneration". Current Neurology and Neuroscience Reports (2019): https://publons.com/publon/36281142/.
    10.1007/S11910-019-0995-Y
  149. Delenclos, Marion; Burgess, Jeremy D.; Lamprokostopoulou, Agaristi; Outeiro, Tiago F.; Vekrellis, Kostas; McLean, Pamela J.. "Cellular models of alpha-synuclein toxicity and aggregation". Journal of Neurochemistry (2019): https://publons.com/publon/36281145/.
    10.1111/JNC.14806
  150. Brasil, Aline de Araujo; Castela de Carvalho, Mariana Dias; Gerhardt, Ellen; Queiroz, Daniela Dias; Pereira, Marcos Dias; Outeiro, Tiago Fleming; Araujo Eleutherio, Elis Cristina. "Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1". Proceedings of the National Academy of Sciences (2019): https://publons.com/publon/31098141/.
    10.1073/PNAS.1902483116
  151. Gonzalez, Nazareno; Arcos-Lopez, Trinidad; Koenig, Annekatrin; Quintanar, Liliana; Menacho Marquez, Mauricio; Outeiro, Tiago F.; Fernandez, Claudio O.. "Effects of alpha-synuclein post-translational modifications on metal binding". Journal of Neurochemistry (2019): https://publons.com/publon/21423472/.
    10.1111/JNC.14721
  152. Paiva, Isabel; Carvalho, Kevin; Santos, Patricia; Cellai, Lucrezia; Pavlou, Maria Angeliki S.; Jain, Gaurav; Gnad, Thorsten; et al. "A(2A)R-induced transcriptional deregulation in astrocytes: An in vitro study". Glia (2019): https://publons.com/publon/30848026/.
    10.1002/GLIA.23688
  153. Ferreira, Carla; Couceiro, Joana; Familia, Carlos; Jardim, Carolina; Antas, Pedro; Santos, Claudia N.; Outeiro, Tiago F.; Tenreiro, Sandra; Quintas, Alexandre. "The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism". FEMS Yeast Research (2019): https://publons.com/publon/21026603/.
    10.1093/FEMSYR/FOZ042
  154. Sampaio-Marques, Belem; Guedes, Ana; Vasilevskiy, Igor; Goncalves, Susana; Outeiro, Tiago F.; Winderickx, Joris; Burhans, William C.; Ludovico, Paula. "alpha-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". Aging Cell (2019): https://publons.com/publon/34927137/.
    10.1111/ACEL.12922
  155. Marvian, Amir Tayaranian; Koss, David J.; Aliakbaris, Farhang; Morshedi, Dina; Outeiro, Tiago Fleming. "In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies". Journal of Neurochemistry (2019): https://publons.com/publon/36281144/.
    10.1111/JNC.14707
  156. Wu, Jia-Zhen; Ardah, Mustafa; Haikal, Caroline; Svanbergsson, Alexander; Diepenbroek, Meike; Vaikath, Nishant N.; Li, Wen; et al. "Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy". Translational Neurodegeneration (2019): https://publons.com/publon/36281149/.
    10.1186/S40035-019-0159-7
  157. Vasili, Eftychia; Dominguez-Meijide, Antonio; Outeiro, Tiago Fleming. "Spreading of alpha-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved". Frontiers in Molecular Neuroscience (2019): https://publons.com/publon/36281151/.
    10.3389/FNMOL.2019.00107
  158. Candelise, Niccolo; Schmitz, Matthias; Llorens, Franc; Villar-Pique, Anna; Cramm, Maria; Thom, Tobias; Correia, Susana Margarida da Silva; et al. "Seeding variability of different alpha synuclein strains in synucleinopathies". Annals of Neurology (2019): https://publons.com/publon/31609895/.
    10.1002/ANA.25446
  159. Szego, Eva M.; Dominguez-Meijide, Antonio; Gerhardt, Ellen; Koenig, Annekatrin; Koss, David J.; Li, Wen; Pinho, Raquel; et al. "Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies". Cell Reports (2019): https://publons.com/publon/29297531/.
    10.1016/J.CELREP.2019.06.009
  160. Chiang, Annette N.; Liang, Mary; Dominguez-Meijide, Antonio; Masaracchia, Caterina; Goeckeler-Fried, Jennifer L.; Mazzone, Carly S.; Newhouse, David W.; et al. "Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding". Bioorganic & Medicinal Chemistry (2019): https://publons.com/publon/36281157/.
    10.1016/J.BMC.2018.11.011
  161. Repici, Mariaelena; Hassanjani, Mahdieh; Maddison, Daniel C.; Garcao, Pedro; Cimini, Sara; Patel, Bhavini; Szegoe, Eva M.; et al. "The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration". Molecular Neurobiology (2019): https://publons.com/publon/35413108/.
    10.1007/S12035-018-1084-Y
  162. Pinho, Raquel; Paiva, Isabel; Jercic, Kristina Gotovac; Fonseca-Ornelas, Luis; Gerhardt, Ellen; Fahlbusch, Christiane; Garcia-Esparcia, Paula; et al. "Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein". Human Molecular Genetics (2019): https://publons.com/publon/20187855/.
    10.1093/HMG/DDY326
  163. Carija, Anita; Pinheiro, Francisca; Pujols, Jordi; Bras, Ines C.; Lazaro, Diana Fernandes; Santambrogio, Carlo; Grandori, Rita; et al. "Biasing the native alpha-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity". Redox Biology (2019): https://publons.com/publon/17794708/.
    10.1016/J.REDOX.2019.101135
  164. Outeiro, Tiago Fleming; Koss, David J.; Erskine, Daniel; Walker, Lauren; Kurzawa-Akanbi, Marzena; Burn, David; Donaghy, Paul; et al. "Dementia with Lewy bodies: an update and outlook". Molecular Neurodegeneration (2019): https://publons.com/publon/28872631/.
    10.1186/S13024-019-0306-8
  165. Prasad, Vibha; Wasser, Yasmine; Hans, Friederike; Goswami, Anand; Katona, Istvan; Outeiro, Tiago F.; Kahle, Philipp J.; Schulz, Joerg B.; Voigt, Aaron. "Monitoring -synuclein multimerization in vivo". The FASEB Journal (2019): https://publons.com/publon/2774927/.
    10.1096/FJ.201800148RRR
  166. Diana Macedo; Carolina Jardim; Inês Figueira; A. Filipa Almeida; Gordon J. McDougall; Derek Stewart; Jose E. Yuste; et al. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". Scientific Reports (2018): https://doi.org/10.1038/s41598-018-25118-z.
    10.1038/s41598-018-25118-z
  167. Paiva, I.; Jain, G.; Lázaro, D.F.; Jercic, K.G.; Hentrich, T.; Kerimoglu, C.; Pinho, R.; et al. "Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function". Neurobiology of Disease 119 (2018): 121-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051272617&partnerID=MN8TOARS.
    10.1016/j.nbd.2018.08.001
  168. Pujols, J.; Peña-Díaz, S.; Lázaro, D.F.; Peccati, F.; Pinheiro, F.; González, D.; Carija, A.; et al. "Small molecule inhibits a-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons". Proceedings of the National Academy of Sciences of the United States of America 115 41 (2018): 10481-10486. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054777635&partnerID=MN8TOARS.
    10.1073/pnas.1804198115
  169. Valiente-Gabioud, A.A.; Riedel, D.; Outeiro, T.F.; Menacho-Márquez, M.A.; Griesinger, C.; Fernández, C.O.. "Binding Modes of Phthalocyanines to Amyloid ß Peptide and Their Effects on Amyloid Fibril Formation". Biophysical Journal 114 5 (2018): 1036-1045. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043497862&partnerID=MN8TOARS.
    10.1016/j.bpj.2018.01.003
  170. Richter, K.N.; Revelo, N.H.; Seitz, K.J.; Helm, M.S.; Sarkar, D.; Saleeb, R.S.; D'Este, E.; et al. "Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy". EMBO Journal 37 1 (2018): 139-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034102627&partnerID=MN8TOARS.
    10.15252/embj.201695709
  171. Bras, I.C.; Tenreiro, S.; Silva, A.M.; Outeiro, T.F.. "Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast". FEMS Yeast Research 18 8 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055079280&partnerID=MN8TOARS.
    10.1093/femsyr/foy108
  172. Konig, A.; Miranda, H.V.; Outeiro, T.F.. "Alpha-synuclein glycation and the action of anti-diabetic agents in Parkinson's disease". Journal of Parkinson's Disease 8 1 (2018): 33-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043588925&partnerID=MN8TOARS.
    10.3233/JPD-171285
  173. Temido-Ferreira, M.; Ferreira, D.G.; Batalha, V.L.; Marques-Morgado, I.; Coelho, J.E.; Pereira, P.; Gomes, R.; et al. "Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors". Molecular Psychiatry (2018): 1-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049064131&partnerID=MN8TOARS.
    10.1038/s41380-018-0110-9
  174. Magalhães, R.S.S.; Popova, B.; Braus, G.H.; Outeiro, T.F.; Eleutherio, E.C.A.. "The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: The roles of Ath1 and Agt1". FEMS Yeast Research 18 6 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060125952&partnerID=MN8TOARS.
    10.1093/femsyr/foy066
  175. Biosa, A.; Outeiro, T.F.; Bubacco, L.; Bisaglia, M.. "Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View". Molecular Neurobiology 55 11 (2018): 8754-8763. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044476238&partnerID=MN8TOARS.
    10.1007/s12035-018-1025-9
  176. Brás, I.C.; Lopes, L.V.; Outeiro, T.F.. "Sensing a-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration". Movement Disorders 33 11 (2018): 1675-1684. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056454715&partnerID=MN8TOARS.
    10.1002/mds.27478
  177. Gustafsson, G.; Lööv, C.; Persson, E.; Lázaro, D.F.; Takeda, S.; Bergström, J.; Erlandsson, A.; et al. "Secretion and Uptake of a-Synuclein Via Extracellular Vesicles in Cultured Cells". Cellular and Molecular Neurobiology 38 8 (2018): 1539-1550. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054564721&partnerID=MN8TOARS.
    10.1007/s10571-018-0622-5
  178. Vaz, R.L.; Outeiro, T.F.; Ferreira, J.J.. "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders: A systematic review". Frontiers in Neurology 9 JUN (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047880162&partnerID=MN8TOARS.
    10.3389/fneur.2018.00347
  179. Brasil, A.A.; Magalhães, R.S.S.; De Carvalho, M.D.C.; Paiva, I.; Gerhardt, E.; Pereira, M.D.; Outeiro, T.F.; Eleutherio, E.C.A.. "Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models". Molecular Neurobiology 55 6 (2018): 5269-5281. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029002551&partnerID=MN8TOARS.
    10.1007/s12035-017-0755-4
  180. Pardo, J.; Abba, M.C.; Lacunza, E.; Ogundele, O.M.; Paiva, I.; Morel, G.R.; Outeiro, T.F.; Goya, R.G.. "IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function". Journals of Gerontology - Series A Biological Sciences and Medical Sciences 73 4 (2018): 459-467. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044071797&partnerID=MN8TOARS.
    10.1093/gerona/glx125
  181. Fourcade, S.; Outeiro, T.F.; Pujol, A.. "SIRT2 in age-related neurodegenerative disorders". Aging 10 3 (2018): 295-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044861292&partnerID=MN8TOARS.
    10.18632/aging.101397
  182. Masaracchia, C.; Hnida, M.; Gerhardt, E.; Lopes da Fonseca, T.; Villar-Pique, A.; Branco, T.; Stahlberg, M.A.; et al. "Membrane binding, internalization, and sorting of alpha-synuclein in the cell". Acta neuropathologica communications 6 1 (2018): 79-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061118900&partnerID=MN8TOARS.
    10.1186/s40478-018-0578-1
  183. Harvey, K.; Outeiro, T.F.. "The role of LRRK2 in cell signalling". Biochemical Society Transactions 47 1 (2018): 197-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062482774&partnerID=MN8TOARS.
    10.1042/BST20180464
  184. Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". (2018): http://www.scopus.com/inward/record.url?scp=85046675039&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-018-25118-z
  185. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". (2018): http://hdl.handle.net/1822/57984.
    10.15698/mic2018.01.607
  186. Biosa, Alice; Outeiro, Tiago F.; Bubacco, Luigi; Bisaglia, Marco. "Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View". Molecular Neurobiology (2018): https://publons.com/publon/16533525/.
    10.1007/S12035-018-1025-9
  187. Richter, Katharina N.; Revelo, Natalia H.; Seitz, Katharina J.; Helm, Martin S.; Sarkar, Deblina; Saleeb, Rebecca S.; D'Este, Elisa; et al. "Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy". The EMBO Journal (2018): https://publons.com/publon/3445621/.
    10.15252/EMBJ.201695709
  188. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andres; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". Microbial Cell (2018): https://publons.com/publon/1927592/.
    10.15698/MIC2018.01.607
  189. Brasil, Aline A.; Magalhes, Rayne S. S.; De Carvalho, Mariana D. C.; Paiva, Isabel; Gerhardt, Ellen; Pereira, Marcos D.; Outeiro, Tiago F.; Eleutherio, Elis C. A.. "Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models". Molecular Neurobiology (2018): https://publons.com/publon/9713482/.
    10.1007/S12035-017-0755-4
  190. Masaracchia, Caterina; Hnida, Marilena; Gerhardt, Ellen; da Fonseca, Tomas Lopes; Villar-Pique, Anna; Branco, Tiago; Stahlberg, Markus A.; et al. "Membrane binding, internalization, and sorting of alpha-synuclein in the cell". Acta Neuropathologica Communications (2018): https://publons.com/publon/16533522/.
    10.1186/S40478-018-0578-1
  191. Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.. "Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review". Frontiers in Neurology (2018): https://publons.com/publon/16533520/.
    10.3389/FNEUR.2018.00347
  192. Bras, Ines Caldeira; Lopes, Luisa V.; Outeiro, Tiago Fleming. "Sensing alpha-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration". Movement Disorders (2018): https://publons.com/publon/36281160/.
    10.1002/MDS.27478
  193. Szego, Eva M.; Outeiro, Tiago F.; Kazantsev, Aleksey G.. "SIRTUINS IN BRAIN AND NEURODEGENERATIVE DISEASE". Introductory Review on Sirtuins in Biology, Aging, and Disease (2018): https://publons.com/publon/36281161/.
    10.1016/B978-0-12-813499-3.00013-7
  194. Magalhaes, Rayne S. S.; Popova, Blagovesta; Braus, Gerhard H.; Outeiro, Tiago F.; Eleutherio, Elis C. A.. "The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1". FEMS Yeast Research (2018): https://publons.com/publon/19316724/.
    10.1093/FEMSYR/FOY066
  195. Oliveira da Silva, M. I.; Outeiro, T. F.; Bamburg, J. R.; Liz, M. A.. "Alpha-Synuclein induces cofilin pathology: implications on the molecular basis of Parkinson's disease". Molecular Biology of the Cell (2018): https://publons.com/publon/33900397/.
  196. Gustafsson, Gabriel; Loov, Camilla; Persson, Emma; Lazaro, Diana F.; Takeda, Shuko; Bergstrom, Joakim; Erlandsson, Anna; et al. "Secretion and Uptake of -Synuclein Via Extracellular Vesicles in Cultured Cells". Cellular and Molecular Neurobiology (2018): https://publons.com/publon/36281159/.
    10.1007/S10571-018-0622-5
  197. Bras, Ines Caldeira; Tenreiro, Sandra; Silva, Andreia M.; Outeiro, Tiago F.. "Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast". FEMS Yeast Research (2018): https://publons.com/publon/33189352/.
    10.1093/FEMSYR/FOY108
  198. Pujols, Jordi; Pena-Diaz, Samuel; Lazaro, Diana F.; Peccati, Francesca; Pinheiro, Francisca; Gonzalez, Danilo; Carija, Anita; et al. "Small molecule inhibits alpha-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons". Proceedings of the National Academy of Sciences (2018): https://publons.com/publon/16533526/.
    10.1073/PNAS.1804198115
  199. Macedo, Diana; Jardim, Carolina; Figueira, Ines; Filipa Almeida, A.; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". Scientific Reports (2018): https://publons.com/publon/16533518/.
    10.1038/S41598-018-25118-Z
  200. Pardo, Joaquin; Abba, Martin C.; Lacunza, Ezequiel; Ogundele, Olalekan M.; Paiva, Isabel; Morel, Gustavo R.; Outeiro, Tiago F.; Goya, Rodolfo G.. "IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function". The Journals of Gerontology: Series A Biological Sciences and Medical Sciences (2018): https://publons.com/publon/9713497/.
    10.1093/GERONA/GLX125
  201. Outeiro, Tiago. "Binding Modes of Phthalocyanines to Amyloid ß Peptide and Their Effects on Amyloid Fibril Formation". Biophysical Journal (2018): https://publons.com/publon/1960117/.
    10.1016/J.BPJ.2018.01.003
  202. Isabel Paiva; Gaurav Jain; Diana F. Lázaro; Kristina Gotovac Jercic; Thomas Hentrich; Cemil Kerimoglu; Raquel Pinho; et al. "Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function". Neurobiology of Disease (2018): https://publons.com/publon/16533523/.
    10.1016/J.NBD.2018.08.001
  203. Tiago Outeiro. "SIRT2 in age-related neurodegenerative disorders". Aging (2018): https://publons.com/publon/11232094/.
    10.18632/AGING.101397
  204. Outeiro, Tiago. "Tau protein in normal and pathological brain". European Journal of Neurology (2018): https://publons.com/publon/16533521/.
  205. Diana F. Lázaro; Maria Angeliki S. Pavlou; Tiago Fleming Outeiro. "Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease". Experimental Neurology 298 (2017): 162-171. https://doi.org/10.1016/j.expneurol.2017.05.007.
    10.1016/j.expneurol.2017.05.007
  206. Diana G Ferreira; Mariana Temido-Ferreira; Hugo Vicente Miranda; Vânia L Batalha; Joana E Coelho; Éva M Szegö; Inês Marques-Morgado; et al. "a-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B". Nature Neuroscience 20 11 (2017): 1569-1579. https://doi.org/10.1038/nn.4648.
    10.1038/nn.4648
  207. Lemos, V.; de Oliveira, R.M.; Naia, L.; Szegö, E.; Ramos, E.; Pinho, S.; Magro, F.; et al. "The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes". Human Molecular Genetics 26 21 (2017): 4105-4117. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034211658&partnerID=MN8TOARS.
    10.1093/hmg/ddx298
  208. Pavlou, M.A.S.; Pinho, R.; Paiva, I.; Outeiro, T.F.. "The yin and yang of a-synuclein-associated epigenetics in Parkinson's disease". Brain 140 4 (2017): 878-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021389594&partnerID=MN8TOARS.
    10.1093/brain/aww227
  209. Cukierman, D.S.; Pinheiro, A.B.; Castiñeiras-Filho, S.L.P.; da Silva, A.S.P.; Miotto, M.C.; De Falco, A.; de P. Ribeiro, T.; et al. "A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies". Journal of Inorganic Biochemistry 170 (2017): 160-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013953674&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2017.02.020
  210. Menges, S.; Minakaki, G.; Schaefer, P.M.; Meixner, H.; Prots, I.; Schlötzer-Schrehardt, U.; Friedland, K.; et al. "Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013831514&partnerID=MN8TOARS.
    10.1038/srep42942
  211. Morais, G.R.; Palma, E.; Marques, F.; Gano, L.; Oliveira, M.C.; Abrunhosa, A.; Miranda, H.V.; et al. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry 54 1 (2017): 255-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952673515&partnerID=MN8TOARS.
    10.1002/jhet.2575
  212. Correia Guedes, L.; Reimão, S.; Paulino, P.; Nunes, R.G.; Bouça-Machado, R.; Abreu, D.; Gonçalves, N.; et al. "Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's disease". Movement Disorders 32 9 (2017): 1331-1333. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022095345&partnerID=MN8TOARS.
    10.1002/mds.27083
  213. Pardo, J.; Abba, M.C.; Lacunza, E.; Francelle, L.; Morel, G.R.; Outeiro, T.F.; Goya, R.G.. "Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats". Hippocampus 27 4 (2017): 435-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010781145&partnerID=MN8TOARS.
    10.1002/hipo.22703
  214. Marciniak, E.; Leboucher, A.; Caron, E.; Ahmed, T.; Tailleux, A.; Dumont, J.; Issad, T.; et al. "Tau deletion promotes brain insulin resistance". Journal of Experimental Medicine 214 8 (2017): 2257-2269. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027337943&partnerID=MN8TOARS.
    10.1084/jem.20161731
  215. Guerreiro, P.S.; Coelho, J.E.; Sousa-Lima, I.; Macedo, P.; Lopes, L.V.; Outeiro, T.F.; Pais, T.F.. "Mutant A53T a-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways". NeuroMolecular Medicine 19 1 (2017): 113-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982291567&partnerID=MN8TOARS.
    10.1007/s12017-016-8435-5
  216. Macedo, D.; Bertolin, T.E.; Oro, T.; Backes, L.T.H.; Brás, I.C.; Santos, C.N.; Tenreiro, S.; Outeiro, T.F.. "Phycocyanin protects against Alpha-Synuclein toxicity in yeast". Journal of Functional Foods 38 (2017): 553-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030530673&partnerID=MN8TOARS.
    10.1016/j.jff.2017.09.044
  217. Turriani, E.; Lázaro, D.F.; Ryazanov, S.; Leonov, A.; Giese, A.; Schön, M.; Schön, M.P.; et al. "Treatment with diphenyl-pyrazole compound anle138b/c reveals that a-synuclein protects melanoma cells from autophagic cell death". Proceedings of the National Academy of Sciences of the United States of America 114 25 (2017): E4971-E4977. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021137524&partnerID=MN8TOARS.
    10.1073/pnas.1700200114
  218. Lissek, T.; Adams, M.; Adelman, J.; Ahissar, E.; Akaaboune, M.; Akil, H.; al'Absi, M.; et al. "Building Bridges through Science". Neuron 96 4 (2017): 730-735. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033693605&partnerID=MN8TOARS.
    10.1016/j.neuron.2017.09.028
  219. Moreira, S.; Fonseca, I.; Nunes, M.J.; Rosa, A.; Lemos, L.; Rodrigues, E.; Carvalho, A.N.; et al. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology 295 (2017): 77-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020310862&partnerID=MN8TOARS.
    10.1016/j.expneurol.2017.05.009
  220. Ferreira, D.G.; Batalha, V.L.; Miranda, H.V.; Coelho, J.E.; Gomes, R.; Gonçalves, F.Q.; Real, J.I.; et al. "Adenosine A2A receptors modulate a-synuclein aggregation and toxicity". Cerebral Cortex 27 1 (2017): 718-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014790138&partnerID=MN8TOARS.
    10.1093/cercor/bhv268
  221. Gustafsson, G.; Eriksson, F.; Möller, C.; da Fonseca, T.L.; Outeiro, T.F.; Lannfelt, L.; Bergström, J.; Ingelsson, M.. "Cellular Uptake of a-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of a-Synuclein and Mediated via Fc¿ Receptors". Cellular and Molecular Neurobiology 37 1 (2017): 121-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960412948&partnerID=MN8TOARS.
    10.1007/s10571-016-0352-5
  222. López-León, M.; Outeiro, T.F.; Goya, R.G.. "Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain". Ageing Research Reviews 40 (2017): 168-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031496529&partnerID=MN8TOARS.
    10.1016/j.arr.2017.09.002
  223. Tenreiro, S.; Franssens, V.; Winderickx, J.; Outeiro, T.F.. "Yeast models of Parkinson's disease-associated molecular pathologies". Current Opinion in Genetics and Development 44 (2017): 74-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013224841&partnerID=MN8TOARS.
    10.1016/j.gde.2017.01.013
  224. Miranda, H.V.; Cássio, R.; Correia-Guedes, L.; Gomes, M.A.; Chegão, A.; Miranda, E.; Soares, T.; et al. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85032025050&partnerID=MN8TOARS.
    10.1038/s41598-017-14175-5
  225. Bozek, T.; Blazekovic, A.; Perkovic, M.N.; Jercic, K.G.; Sustar, A.; Smircic-Duvnjak, L.; Outeiro, T.F.; Pivac, N.; Borovecki, F.. "The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus". Diabetology and Metabolic Syndrome 9 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85037621295&partnerID=MN8TOARS.
    10.1186/s13098-017-0295-0
  226. Roodveldt, C.; Outeiro, T.F.; Braun, J.E.A.. "Editorial: Molecular chaperones and neurodegeneration". Frontiers in Neuroscience 11 OCT (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85031110620&partnerID=MN8TOARS.
    10.3389/fnins.2017.00565
  227. Szego, É.M.; Gerhardt, E.; Outeiro, T.F.. "Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3ß/ß-catenin pathway". Neurobiology of Aging 56 (2017): 7-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018946423&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2017.04.001
  228. Guedes, L.C.; Chan, R.B.; Gomes, M.A.; Conceição, V.A.; Machado, R.B.; Soares, T.; Xu, Y.; et al. "Serum lipid alterations in GBA-associated Parkinson's disease". Parkinsonism and Related Disorders 44 (2017): 58-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028846284&partnerID=MN8TOARS.
    10.1016/j.parkreldis.2017.08.026
  229. Gonçalves, S.A.; Outeiro, T.F.. "Traffic jams and the complex role of a-Synuclein aggregation in Parkinson disease". Small GTPases 8 2 (2017): 78-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978120353&partnerID=MN8TOARS.
    10.1080/21541248.2016.1199191
  230. Villar-Piqué, A.; Rossetti, G.; Ventura, S.; Carloni, P.; Fernández, C.O.; Outeiro, T.F.. "Copper(II) and the pathological H50Q a-synuclein mutant: Environment meets genetics". Communicative and Integrative Biology 10 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013288185&partnerID=MN8TOARS.
    10.1080/19420889.2016.1270484
  231. Branco-Santos, J.; Herrera, F.; Poças, G.M.; Pires-Afonso, Y.; Giorgini, F.; Domingos, P.M.; Outeiro, T.F.. "Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity". Human Molecular Genetics 26 19 (2017): 3763-3775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030697664&partnerID=MN8TOARS.
    10.1093/hmg/ddx260
  232. Francelle, L.; Lotz, C.; Outeiro, T.; Brouillet, E.; Merienne, K.. "Contribution of neuroepigenetics to Huntington’s disease". Frontiers in Human Neuroscience 11 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013998533&partnerID=MN8TOARS.
    10.3389/fnhum.2017.00017
  233. Paiva, I.; Pinho, R.; Pavlou, M.A.; Hennion, M.; Wales, P.; Schütz, A.-L.; Rajput, A.; et al. "Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage". Human molecular genetics 26 12 (2017): 2231-2246. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030984416&partnerID=MN8TOARS.
    10.1093/hmg/ddx114
  234. Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". (2017): http://hdl.handle.net/10451/32818.
    10.1093/brain/awx056
  235. Guedes, Leonor Correia; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; et al. "Neuromelanin magnetic resonance imaging of the Substantia Nigra in LRRK2-related Parkinson’s Disease". (2017): http://hdl.handle.net/10400.26/29908.
    10.1002/mds.27083
  236. Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M.A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". (2017): http://hdl.handle.net/10400.18/5439.
    10.1093/brain/awx056
  237. Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". (2017): http://hdl.handle.net/10400.26/19438.
    10.1093/brain/awx056
  238. Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". (2017): http://www.scopus.com/inward/record.url?scp=85032025050&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-017-14175-5
  239. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. "The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". (2017): http://hdl.handle.net/10400.18/5465.
    10.1371/journal.pbio.2000374
  240. Lissek, Thomas; Adams, Michelle; Adelman, John; Ahissar, Ehud; Akaaboune, Mohammed; Akil, Huda; a'Absi, Mustafa; et al. "Building Bridges through Science". Neuron (2017): https://publons.com/publon/3619594/.
    10.1016/J.NEURON.2017.09.028
  241. Menges, Stefanie; Minakaki, Georgia; Schaefer, Patrick M.; Meixner, Holger; Prots, Iryna; Schloetzer-Schrehardt, Ursula; Friedland, Kristina; et al. "Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress". Scientific Reports (2017): https://publons.com/publon/3777077/.
    10.1038/SREP42942
  242. Ferreira, Diana G.; Batalha, Vania L.; Vicente Miranda, Hugo; Coelho, Joana E.; Gomes, Rui; Goncalves, Francisco Q.; Real, Joana I.; et al. "Adenosine A(2A) Receptors Modulate alpha-Synuclein Aggregation and Toxicity". Cerebral Cortex (2017): https://publons.com/publon/6120877/.
    10.1093/CERCOR/BHV268
  243. Ferreira, Diana G.; Temido-Ferreira, Mariana; Miranda, Hugo Vicente; Batalha, Vania L.; Coelho, Joana E.; Szego, Eva M.; Marques-Morgado, Ines; et al. "alpha-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B". Nature Neuroscience (2017): https://publons.com/publon/8811208/.
    10.1038/NN.4648
  244. Guedes, Leonor Correia; Reimao, Sofia; Paulino, Patricia; Nunes, Rita G.; Bouca-Machado, Raquel; Abreu, Daisy; Goncalves, Nilza; et al. "Neuromelanin Magnetic Resonance Imaging of the Substantia Nigra in LRRK2-Related Parkinson's Disease". Movement Disorders (2017): https://publons.com/publon/9713491/.
    10.1002/MDS.27083
  245. Vicente Miranda, Hugo; Szego, Eva M.; Oliveira, Luis M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. "Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies". Brain (2017): https://publons.com/publon/4086195/.
    10.1093/BRAIN/AWX056
  246. Guerreiro, Patricia S.; Coelho, Joana E.; Sousa-Lima, Ines; Macedo, Paula; Lopes, Luisa V.; Outeiro, Tiago F.; Pais, Teresa F.. "Mutant A53T alpha-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways". NeuroMolecular Medicine (2017): https://publons.com/publon/9713501/.
    10.1007/S12017-016-8435-5
  247. Paiva, Isabel; Pinho, Raquel; Pavlou, Maria Angeliki; Hennion, Magali; Wales, Pauline; Schuetz, Anna-Lena; Rajput, Ashish; et al. "Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage". Human Molecular Genetics (2017): https://publons.com/publon/9713496/.
    10.1093/HMG/DDX114
  248. Lemos, Vera; de Oliveira, Rita M.; Naia, Luana; Szego, Eva; Ramos, Elisabete; Pinho, Sonia; Magro, Fernando; et al. "The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes". Human Molecular Genetics (2017): https://publons.com/publon/8796099/.
    10.1093/HMG/DDX298
  249. Cukierman, Daphne Schneider; Pinheiro, Ana Beatriz; Castineiras-Filho, Sergio L. P.; da Silva, Anastacia Sa P.; Miotto, Marco C.; De Falco, Anna; Ribeiro, Thales de P.; et al. "A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies". Journal of Inorganic Biochemistry (2017): https://publons.com/publon/3512201/.
    10.1016/J.JINORGBIO.2017.02.020
  250. Outeiro, Tiago. "Disease-modification in Translational Models of Parkinson's disease by the Rho Kinase Inhibitor Fasudil". Movement Disorders (2017): https://publons.com/publon/9713493/.
  251. Vicente Miranda, Hugo; Cassio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos Antonio; Chegao, Ana; Miranda, Elisa; Soares, Tiago; et al. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". Scientific Reports (2017): https://publons.com/publon/2125195/.
    10.1038/S41598-017-14175-5
  252. Guedes, Leonor Correia; Chan, Robin Barry; Gomes, Marcos Antonio; Conceicao, Vasco A.; Machado, Raquel Bouca; Soares, Tiago; Xu, Yimeng; et al. "Serum lipid alterations in GBA-associated Parkinson's disease". Parkinsonism and Related Disorders (2017): https://publons.com/publon/1334367/.
    10.1016/J.PARKRELDIS.2017.08.026
  253. Morais, Goreti Ribeiro; Palma, Elisa; Marques, Fernanda; Gano, Lurdes; Oliveira, Maria Cristina; Abrunhosa, Antero; Vicente Miranda, Hugo; et al. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry (2017): https://publons.com/publon/8811211/.
    10.1002/JHET.2575
  254. Pinho, Raquel; Guedes, Leonor C.; Soreq, Lilach; Lobo, Patricia P.; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M.; et al. "Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles (vol 11, e157852, 2016)". Plos One (2017): https://publons.com/publon/9206717/.
    10.1371/JOURNAL.PONE.0190552
  255. de Oliveira, Rita Machado; Miranda, Hugo Vicente; Francelle, Laetitia; Pinho, Raquel; Szego, Eva M.; Martinho, Renato; Munari, Francesca; et al. "The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease (vol 15, e2000374, 2017)". PLoS Biology (2017): https://publons.com/publon/4086202/.
    10.1371/JOURNAL.PBIO.1002601
  256. Branco-Santos, Joana; Herrera, Federico; Pocas, Goncalo M.; Pires-Afonso, Yolanda; Giorgini, Flaviano; Domingos, Pedro M.; Outeiro, Tiago F.. "Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity". Human Molecular Genetics (2017): https://publons.com/publon/7195193/.
    10.1093/HMG/DDX260
  257. Oliveira da Silva, M. I.; Outeiro, T. F.; Bamburg, J. R.; Liz, M. A.. "Cofilin-actin rods as mediators of alpha-synuclein-induced synaptic dysfunction in Parkinson's disease". Molecular Biology of the Cell (2017): https://publons.com/publon/16533540/.
  258. Bozek, Tomislav; Blazekovic, Antonela; Perkovic, Matea Nikolac; Jercic, Kristina Gotovac; Sustar, Aleksandra; Smircic-Duvnjak, Lea; Outeiro, Tiago F.; Pivac, Nela; Borovecki, Fran. "The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus". Diabetology & Metabolic Syndrome (2017): https://publons.com/publon/16533539/.
    10.1186/S13098-017-0295-0
  259. Macedo, Diana; Bertolin, Telma Elita; Oro, Tatiana; Hartmann Backes, Luana Tais; Bras, Ines Caldeira; Santos, Claudia Nunes; Tenreiro, Sandra; Outeiro, Tiago Fleming. "Phycocyanin protects against Alpha-Synuclein toxicity in yeast". Journal of Functional Foods (2017): https://publons.com/publon/8008033/.
    10.1016/J.JFF.2017.09.044
  260. Guedes, L. Correia; Reimao, S.; Paulino, P.; Nunes, R.; Bouca, R.; Abreu, D.; Goncalves, N.; et al. "Neuromelanin Magnetic Resonance Imaging of the Substatia Nigra in LRRK2-related Parkinson's disease". Movement Disorders (2017): https://publons.com/publon/9713494/.
  261. Outeiro, Tiago. "Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats". Hippocampus (2017): https://publons.com/publon/461326/.
    10.1002/HIPO.22703
  262. Outeiro, Tiago. "Contribution of Neuroepigenetics to Huntington’s Disease". Frontiers in Human Neuroscience (2017): https://publons.com/publon/1510713/.
    10.3389/FNHUM.2017.00017
  263. Gustafsson, Gabriel; Eriksson, Fredrik; Moller, Christer; da Fonseca, Tomas Lopes; Outeiro, Tiago F.; Lannfelt, Lars; Bergstrom, Joakim; Ingelsson, Martin. "Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors". Cellular and Molecular Neurobiology (2017): https://publons.com/publon/9713478/.
    10.1007/S10571-016-0352-5
  264. Outeiro, Tiago. "Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3ß/ß-catenin pathway". Neurobiology of Aging (2017): https://publons.com/publon/9713498/.
    10.1016/J.NEUROBIOLAGING.2017.04.001
  265. Outeiro, Tiago. "Motor and Nonmotor clinical phenotype in LRRK2 Parkinson's disease patients: A Case-control study". Movement Disorders (2017): https://publons.com/publon/9713495/.
  266. Outeiro, Tiago. "Yeast models of Parkinson’s disease-associated molecular pathologies". Current Opinion in Genetics & Development (2017): https://publons.com/publon/9713499/.
    10.1016/J.GDE.2017.01.013
  267. Outeiro, Tiago. "The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLoS Biology (2017): https://publons.com/publon/4086201/.
    10.1371/JOURNAL.PBIO.2000374
  268. Moreira, Sara; Fonseca, Ines; Nunes, Maria Joao; Rosa, Alexandra; Lemos, Luisa; Rodrigues, Elsa; Carvalho, Andreia Neves; et al. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology (2017): https://publons.com/publon/9713488/.
    10.1016/J.EXPNEUROL.2017.05.009
  269. Outeiro, Tiago. "Editorial: Molecular Chaperones and Neurodegeneration". Frontiers in Neuroscience (2017): https://publons.com/publon/9713483/.
    10.3389/FNINS.2017.00565
  270. Outeiro, Tiago. "Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain". Ageing Research Reviews (2017): https://publons.com/publon/9713479/.
    10.1016/J.ARR.2017.09.002
  271. Outeiro, Tiago. "The yin and yang of alpha-synuclein-associated epigenetics in Parkinson's disease". Brain (2017): https://publons.com/publon/9713502/.
    10.1093/BRAIN/AWW227
  272. Outeiro, Tiago. "Treatment with diphenyl–pyrazole compound anle138b/c reveals that a-synuclein protects melanoma cells from autophagic cell death". Proceedings of the National Academy of Sciences (2017): https://publons.com/publon/6041460/.
    10.1073/PNAS.1700200114
  273. Outeiro, Tiago. "Tau deletion promotes brain insulin resistance". Journal of Experimental Medicine (2017): https://publons.com/publon/3318326/.
    10.1084/JEM.20161731
  274. Pavlou MAS; Outeiro TF. "Epigenetics in Parkinson's Disease". Fortschritte der Neurologie Psychiatrie (2017): https://publons.com/publon/9713476/.
    10.1055/S-0042-104501
  275. Outeiro, Tiago. "Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease". Experimental Neurology (2017): https://publons.com/publon/9713500/.
    10.1016/J.EXPNEUROL.2017.05.007
  276. "SYNUCLEIN MISFOLDING AS A THERAPEUTIC TARGET". Disease-modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-modifying Therapies (2017): https://publons.com/publon/16533535/.
    10.1016/B978-0-12-805120-7.00002-6
  277. Guerreiro, P.S.; Gerhardt, E.; Lopes da Fonseca, T.; Bähr, M.; Outeiro, T.F.; Eckermann, K.. "LRRK2 Promotes Tau Accumulation, Aggregation and Release". Molecular Neurobiology 53 5 (2016): 3124-3135. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930155887&partnerID=MN8TOARS.
    10.1007/s12035-015-9209-z
  278. Batalha, V.L.; Ferreira, D.G.; Coelho, J.E.; Valadas, J.S.; Gomes, R.; Temido-Ferreira, M.; Shmidt, T.; et al. "The caffeine-binding adenosine A 2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84982190182&partnerID=MN8TOARS.
    10.1038/srep31493
  279. Vicente Miranda, H.; El-Agnaf, O.M.A.; Outeiro, T.F.. "Glycation in Parkinson's disease and Alzheimer's disease". Movement Disorders 31 6 (2016): 782-790. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959455993&partnerID=MN8TOARS.
    10.1002/mds.26566
  280. Pinho, R.; Guedes, L.C.; Soreq, L.; Lobo, P.P.; Mestre, T.; Coelho, M.; Rosa, M.M.; et al. "Gene expression differences in peripheral blood of Parkinson's disease patients with distinct progression profiles". PLoS ONE 11 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84995640664&partnerID=MN8TOARS.
    10.1371/journal.pone.0157852
  281. Villar-Piqué, A.; Da Fonseca, T.L.; Sant'Anna, R.; Szegö, E.M.; Fonseca-Ornelas, L.; Pinho, R.; Carija, A.; et al. "Environmental and genetic factors support the dissociation between a-synuclein aggregation and toxicity". Proceedings of the National Academy of Sciences of the United States of America 113 42 (2016): E6506-E6515. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991593758&partnerID=MN8TOARS.
    10.1073/pnas.1606791113
  282. Kleinknecht, A.; Popova, B.; Lázaro, D.F.; Pinho, R.; Valerius, O.; Outeiro, T.F.; Braus, G.H.. "C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of a-Synuclein in a Yeast Model of Parkinson's Disease". PLoS Genetics 12 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84977572976&partnerID=MN8TOARS.
    10.1371/journal.pgen.1006098
  283. Lázaro, D.F.; Dias, M.C.; Carija, A.; Navarro, S.; Madaleno, C.S.; Tenreiro, S.; Ventura, S.; Outeiro, T.F.. "The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation". Acta neuropathologica communications 4 1 (2016): 128-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032163782&partnerID=MN8TOARS.
    10.1186/s40478-016-0402-8
  284. Villar-Piqué, A.; Lopes da Fonseca, T.; Outeiro, T.F.. "Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies". Journal of Neurochemistry 139 (2016): 240-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941584642&partnerID=MN8TOARS.
    10.1111/jnc.13249
  285. Tenreiro, S.; Rosado-Ramos, R.; Gerhardt, E.; Favretto, F.; Magalhães, F.; Popova, B.; Becker, S.; et al. "Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity". Human Molecular Genetics 25 2 (2016): 275-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960800242&partnerID=MN8TOARS.
    10.1093/hmg/ddv470
  286. Letra-Vilela, R.; Sánchez-Sánchez, A.M.; Rocha, A.M.; Martin, V.; Branco-Santos, J.; Puente-Moncada, N.; Santa-Marta, M.; et al. "Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin". Molecular and Cellular Endocrinology 434 (2016): 238-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978194791&partnerID=MN8TOARS.
    10.1016/j.mce.2016.07.012
  287. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356". Autophagy 12 2 (2016): 443-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054826264&partnerID=MN8TOARS.
    10.1080/15548627.2016.1147886
  288. Fernandes, J.T.S.; Chutna, O.; Chu, V.; Conde, J.P.; Outeiro, T.F.. "A novel microfluidic cell co-culture platform for the study of the molecular mechanisms of Parkinson's disease and other synucleinopathies". Frontiers in Neuroscience 10 NOV (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009812444&partnerID=MN8TOARS.
    10.3389/fnins.2016.00511
  289. Vicente Miranda, H.; Gomes, M.A.; Branco-Santos, J.; Breda, C.; Lázaro, D.F.; Lopes, L.V.; Herrera, F.; Giorgini, F.; Outeiro, T.F.. "Glycation potentiates neurodegeneration in models of Huntington's disease". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84995899643&partnerID=MN8TOARS.
    10.1038/srep36798
  290. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013763791&partnerID=MN8TOARS.
    10.1080/15548627.2015.1100356
  291. Pardo, J.; Uriarte, M.; Cónsole, G.M.; Reggiani, P.C.; Outeiro, T.F.; Morel, G.R.; Goya, R.G.. "Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats". European Journal of Neuroscience 44 4 (2016): 2120-2128. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982198660&partnerID=MN8TOARS.
    10.1111/ejn.13278
  292. Tatenhorst, L.; Eckermann, K.; Dambeck, V.; Fonseca-Ornelas, L.; Walle, H.; Lopes da Fonseca, T.; Koch, J.C.; et al. "Fasudil attenuates aggregation of a-synuclein in models of Parkinson's disease". Acta neuropathologica communications 4 (2016): 39-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012045663&partnerID=MN8TOARS.
    10.1186/s40478-016-0310-y
  293. Fonseca, T.L.; Pinho, R.; Outeiro, T.F.. "A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death". Human Molecular Genetics 25 14 (2016): 2959-2971. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016114336&partnerID=MN8TOARS.
    10.1093/hmg/ddw147
  294. Oliveira, A.O.; Osmand, A.; Outeiro, T.F.; Muchowski, P.J.; Finkbeiner, S.. "aB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease". Human Molecular Genetics 25 9 (2016): 1677-1689. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991284361&partnerID=MN8TOARS.
    10.1093/hmg/ddw028
  295. Pinho, Raquel; Guedes, Leonor C.; Soreq, Lilach; Lobo, Patricia P.; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M.; et al. "Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles". Plos One (2016): https://publons.com/publon/9206752/.
    10.1371/JOURNAL.PONE.0157852
  296. Lazaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina Silva; Tenreiro, Sandra; Ventura, Salvador; Outeiro, Tiago F.. "The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation". Acta Neuropathologica Communications (2016): https://publons.com/publon/4040472/.
    10.1186/S40478-016-0402-8
  297. Outeiro, Tiago Fleming; Miranda, Hugo V.. "GLYCATION POTENTIATES NEURODEGENERATION IN MODELS OF HUNTINGTON'S DISEASE". Journal of Neurology, Neurosurgery & Psychiatry (2016): https://publons.com/publon/33896658/.
    10.1136/JNNP-2016-314597.38
  298. Letra-Vilela, Ricardo; Maria Sanchez-Sanchez, Ana; Rocha, Ana Maia; Martin, Vanesa; Branco-Santos, Joana; Puente-Moncada, Noelia; Santa-Marta, Mariana; et al. "Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin". Molecular and Cellular Endocrinology (2016): https://publons.com/publon/2761905/.
    10.1016/J.MCE.2016.07.012
  299. Villar-Pique, Anna; da Fonseca, Tomas Lopes; Sant'Anna, Ricardo; Szegoe, Eva Monika; Fonseca-Ornelas, Luis; Pinho, Raquel; Carija, Anita; et al. "Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity". Proceedings of the National Academy of Sciences (2016): https://publons.com/publon/4040460/.
    10.1073/PNAS.1606791113
  300. Batalha, Vania L.; Ferreira, Diana G.; Coelho, Joana E.; Valadas, Jorge S.; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; et al. "The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function". Scientific Reports (2016): https://publons.com/publon/5601783/.
    10.1038/SREP31493
  301. Outeiro, Tiago. "Glycation potentiates neurodegeneration in models of Huntington’s disease". Scientific Reports (2016): https://publons.com/publon/7195194/.
    10.1038/SREP36798
  302. João T. S. Fernandes; Oldriska Chutna; Virginia Chu; João P. Conde; Tiago F. Outeiro. "A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies". Frontiers in Neuroscience (2016): https://publons.com/publon/9713477/.
    10.3389/FNINS.2016.00511
  303. da Fonseca, Tomas Lopes; Pinho, Raquel; Outeiro, Tiago F.. "A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death". Human Molecular Genetics (2016): https://publons.com/publon/9713487/.
    10.1093/HMG/DDW147
  304. Outeiro, Tiago. "Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats". European Journal of Neuroscience (2016): https://publons.com/publon/9713480/.
    10.1111/EJN.13278
  305. Villar-Pique, Anna; da Fonseca, Tomas Lopes; Outeiro, Tiago Fleming. "Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies". Journal of Neurochemistry (2016): https://publons.com/publon/9713481/.
    10.1111/JNC.13249
  306. Outeiro, Tiago. "ROCK Inhibition by Fasudil as Disease-Modifying Translational Approach in the Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis". Neurology (2016): https://publons.com/publon/9713512/.
  307. Guerreiro, Patricia Silva; Gerhardt, Ellen; da Fonseca, Tomas Lopes; Baehr, Mathias; Outeiro, Tiago Fleming; Eckermann, Katrin. "LRRK2 Promotes Tau Accumulation, Aggregation and Release". Molecular Neurobiology (2016): https://publons.com/publon/9713486/.
    10.1007/S12035-015-9209-Z
  308. Outeiro, Tiago. "C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of a-Synuclein in a Yeast Model of Parkinson's Disease". PLOS Genetics (2016): https://publons.com/publon/9713485/.
    10.1371/JOURNAL.PGEN.1006098
  309. Outeiro, Tiago. "aB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease". Human Molecular Genetics (2016): https://publons.com/publon/9713484/.
    10.1093/HMG/DDW028
  310. Outeiro, Tiago. "Glycation in Parkinson's disease and Alzheimer's disease". Movement Disorders (2016): https://publons.com/publon/8811206/.
    10.1002/MDS.26566
  311. Outeiro, Tiago. "Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity". Human Molecular Genetics (2016): https://publons.com/publon/1015919/.
    10.1093/HMG/DDV470
  312. Goncalves, Susana A.; Macedo, Diana; Raquel, Helena; Simoes, Pedro D.; Giorgini, Flaviano; Ramalho, Jose S.; Barral, Duarte C.; Moita, Luis Ferreira; Outeiro, Tiago Fleming. "shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity". PLOS Genetics (2016): https://publons.com/publon/9713513/.
    10.1371/JOURNAL.PGEN.1005995
  313. Tatenhorst, Lars; Eckermann, Katrin; Dambeck, Vivian; Fonseca-Ornelas, Luis; Walle, Hagen; da Fonseca, Tomas Lopes; Koch, Jan C.; et al. "Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease". Acta Neuropathologica Communications (2016): https://publons.com/publon/9713492/.
    10.1186/S40478-016-0310-Y
  314. da Fonseca, T.L.; Villar-Piqué, A.; Outeiro, T.F.. "The interplay between alpha-synuclein clearance and spreading". Biomolecules 5 2 (2015): 435-471. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012094057&partnerID=MN8TOARS.
    10.3390/biom5020435
  315. Gomes, P.; Fleming Outeiro, T.; Cavadas, C.. "Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism". Trends in Pharmacological Sciences 36 11 (2015): 756-768. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946227815&partnerID=MN8TOARS.
    10.1016/j.tips.2015.08.001
  316. Nunes, P.; Morais, G.R.; Palma, E.; Silva, F.; Oliveira, M.C.; Ferreira, V.F.C.; Mendes, F.; et al. "Isostructural Re(i)/99mTc(i) tricarbonyl complexes for cancer theranostics". Organic and Biomolecular Chemistry 13 18 (2015): 5182-5194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928905685&partnerID=MN8TOARS.
    10.1039/c5ob00124b
  317. Macedo, D.; Tavares, L.; McDougall, G.J.; Vicente Miranda, H.; Stewart, D.; Ferreira, R.B.; Tenreiro, S.; Outeiro, T.F.; Santos, C.N.. "(Poly)phenols protect from a-synuclein toxicity by reducing oxidative stress and promoting autophagy". Human Molecular Genetics 24 6 (2015): 1717-1732. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936072266&partnerID=MN8TOARS.
    10.1093/hmg/ddu585
  318. Breda, C.; Nugent, M.L.; Estranero, J.G.; Kyriacou, C.P.; Outeiro, T.F.; Steinert, J.R.; Giorgini, F.. "Rab11 modulates a-synuclein-mediated defects in synaptic transmission and behaviour". Human Molecular Genetics 24 4 (2015): 1077-1091. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922431034&partnerID=MN8TOARS.
    10.1093/hmg/ddu521
  319. Chen, X.; Wales, P.; Quinti, L.; Zuo, F.; Moniot, S.; Herisson, F.; Rauf, N.A.; et al. "The sirtuin-2 inhibitor AK7 is neuroprotective in models of parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia". PLoS ONE 10 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84921747158&partnerID=MN8TOARS.
    10.1371/journal.pone.0116919
  320. Blum, D.; Herrera, F.; Francelle, L.; Mendes, T.; Basquin, M.; Obriot, H.; Demeyer, D.; et al. "Mutant huntingtin alters Tau phosphorylation and subcellular distribution". Human Molecular Genetics 24 1 (2015): 76-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922569176&partnerID=MN8TOARS.
    10.1093/hmg/ddu421
  321. Krey, L.; Lühder, F.; Kusch, K.; Czech-Zechmeister, B.; Könnecke, B.; Outeiro, T.F.; Trendelenburg, G.. "Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice". Journal of Cerebral Blood Flow and Metabolism 35 12 (2015): 2080-2088. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948712135&partnerID=MN8TOARS.
    10.1038/jcbfm.2015.178
  322. Ducic, T.; Carboni, E.; Lai, B.; Chen, S.; Michalke, B.; Lázaro, D.F.; Outeiro, T.F.; et al. "Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium". ACS Chemical Neuroscience 6 10 (2015): 1769-1779. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945580347&partnerID=MN8TOARS.
    10.1021/acschemneuro.5b00093
  323. Oliveira, L.M.A.; Falomir-Lockhart, L.J.; Botelho, M.G.; Lin, K.-H.; Wales, P.; Koch, J.C.; Gerhardt, E.; et al. "Elevated a-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells". Cell Death and Disease 6 11 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84989857779&partnerID=MN8TOARS.
    10.1038/cddis.2015.318
  324. Mbefo, M.K.; Fares, M.-B.; Paleologou, K.; Oueslati, A.; Yin, G.; Tenreiro, S.; Pinto, M.; et al. "Parkinson disease mutant E46K enhances a-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo". Journal of Biological Chemistry 290 15 (2015): 9412-9427. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927144360&partnerID=MN8TOARS.
    10.1074/jbc.M114.610774
  325. Moree, B.; Yin, G.; Lázaro, D.F.; Munari, F.; Strohäker, T.; Giller, K.; Becker, S.; et al. "Small molecules detected by second-harmonic generation modulate the conformation of monomeric a-synuclein and reduce its aggregation in cells". Journal of Biological Chemistry 290 46 (2015): 27582-27593. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946949732&partnerID=MN8TOARS.
    10.1074/jbc.M114.636027
  326. Amen, T.; Lázaro, D.F.; Outeiro, T.F.; Kaganovich, D.. "Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease". Israel Journal of Chemistry 55 11-12 (2015): 1252-1259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950137567&partnerID=MN8TOARS.
    10.1002/ijch.201500071
  327. Vreja, I.C.; Nikic, I.; Göttfert, F.; Bates, M.; Kröhnert, K.; Outeiro, T.F.; Hell, S.W.; Lemke, E.A.; Rizzoli, S.O.. "Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies". ACS Nano 9 11 (2015): 11034-11041. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948422754&partnerID=MN8TOARS.
    10.1021/acsnano.5b04434
  328. Menezes, R.; Tenreiro, S.; Macedo, D.; Santos, C.N.; Outeiro, T.F.. "From the baker to the bedside: Yeast models of parkinson's disease". Microbial Cell 2 8 (2015): 262-279. http://www.scopus.com/inward/record.url?eid=2-s2.0-84997710578&partnerID=MN8TOARS.
    10.15698/mic2015.08.219
  329. Ducic, Tanja; Carboni, Eleonora; Lai, Barry; Chen, Si; Michalke, Bernhard; Lazaro, Diana F.; Outeiro, Tiago F.; et al. "Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium". ACS Chemical Neuroscience (2015): https://publons.com/publon/9713517/.
    10.1021/ACSCHEMNEURO.5B00093
  330. Menezes, Regina; Tenreiro, Sandra; Macedo, Diana; Santos, Claudia N.; Outeiro, Tiago Fleming. "From the baker to the bedside: yeast models of Parkinson's disease". Microbial Cell (2015): https://publons.com/publon/457672/.
    10.15698/MIC2015.08.219
  331. Outeiro, Tiago. "Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease". Israel Journal of Chemistry (2015): https://publons.com/publon/9713514/.
    10.1002/IJCH.201500071
  332. Nunes, Patrique; Morais, Goreti Ribeiro; Palma, Elisa; Silva, Francisco; Oliveira, Maria Cristina; Ferreira, Vera F. C.; Mendes, Filipa; et al. "Isostructural Re(I)/Tc-99m(I) tricarbonyl complexes for cancer theranostics". Organic & Biomolecular Chemistry (2015): https://publons.com/publon/5557214/.
    10.1039/C5OB00124B
  333. Pocas, Goncalo M.; Branco-Santos, Joana; Herrera, Federico; Outeiro, Tiago Fleming; Domingos, Pedro M.. "alpha-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila". Human Molecular Genetics (2015): https://publons.com/publon/4234980/.
    10.1093/HMG/DDU606
  334. Breda, Carlo; Nugent, Marie L.; Estranero, Jasper G.; Kyriacou, Charalambos P.; Outeiro, Tiago F.; Steinert, Joern R.; Giorgini, Flaviano. "Rab11 modulates alpha-synuclein-mediated defects in synaptic transmission and behaviour". Human Molecular Genetics (2015): https://publons.com/publon/9713515/.
    10.1093/HMG/DDU521
  335. Mbefo, Martial Kamdem; Fares, Mohamed-Bilal; Paleologou, Katerina; Oueslati, Abid; Yin, Guowei; Tenreiro, Sandra; Pinto, Madalena; et al. "Parkinson Disease Mutant E46K Enhances alpha-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo". Journal of Biological Chemistry (2015): https://publons.com/publon/4086220/.
    10.1074/JBC.M114.610774
  336. Vreja, Ingrid C.; Nikic, Ivana; Goettfert, Fabian; Bates, Mark; Kroehnert, Katharina; Outeiro, Tiago F.; Hell, Stefan W.; Lemke, Edward A.; Rizzoli, Silvio O.. "Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies". ACS Nano (2015): https://publons.com/publon/3445635/.
    10.1021/ACSNANO.5B04434
  337. Outeiro, Tiago. "The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia". Plos One (2015): https://publons.com/publon/9713519/.
    10.1371/JOURNAL.PONE.0116919
  338. da Fonseca, Tomas Lopes; Villar-Pique, Anna; Outeiro, Tiago Fleming. "The Interplay between Alpha-Synuclein Clearance and Spreading". Biomolecules (2015): https://publons.com/publon/9713520/.
    10.3390/BIOM5020435
  339. Outeiro, Tiago. "Mutant huntingtin alters Tau phosphorylation and subcellular distribution". Human Molecular Genetics (2015): https://publons.com/publon/5601694/.
    10.1093/HMG/DDU421
  340. Outeiro, Tiago. "(Poly)phenols protect from alpha-synuclein toxicity by reducing oxidative stress and promoting autophagy". Human Molecular Genetics (2015): https://publons.com/publon/7124401/.
    10.1093/HMG/DDU585
  341. Outeiro, Tiago. "Knockout of Silent Information Regulator 2 (SIRT2) Preserves Neurological Function after Experimental Stroke in Mice". Journal of Cerebral Blood Flow & Metabolism (2015): https://publons.com/publon/9713510/.
    10.1038/JCBFM.2015.178
  342. Outeiro, Tiago. "The baker, sugar, and the molecular basis of Parkinson's disease". Yeast (2015): https://publons.com/publon/9713516/.
  343. Gomes, Pedro; Outeiro, Tiago Fleming; Cavadas, Claudia. "Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism". Trends in Pharmacological Sciences (2015): https://publons.com/publon/9713518/.
    10.1016/J.TIPS.2015.08.001
  344. Moree, Ben; Yin, Guowei; Lazaro, Diana F.; Munari, Francesca; Strohaeker, Timo; Giller, Karin; Becker, Stefan; et al. "Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric alpha-Synuclein and Reduce Its Aggregation in Cells". Journal of Biological Chemistry (2015): https://publons.com/publon/9713509/.
    10.1074/JBC.M114.636027
  345. Outeiro, Tiago. "Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells". Cell Death and Disease (2015): https://publons.com/publon/4941011/.
    10.1038/CDDIS.2015.318
  346. Rodrigues TM; Jerónimo-Santos A; Outeiro TF; Sebastião AM; Diógenes MJ. "Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.". (2014): http://europepmc.org/abstract/med/24610720.
    10.1007/s40266-014-0160-x
  347. McFarland KN; Huizenga MN; Darnell SB; Sangrey GR; Berezovska O; Cha JH; Outeiro TF; Sadri-Vakili G. "MeCP2: a novel Huntingtin interactor.". (2014): http://europepmc.org/abstract/med/24105466.
    10.1093/hmg/ddt499
  348. Sajjad MU; Green EW; Miller-Fleming L; Hands S; Herrera F; Campesan S; Khoshnan A; et al. "DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease.". (2014): http://europepmc.org/abstract/med/24070869.
    10.1093/hmg/ddt466
  349. Vittori A; Breda C; Repici M; Orth M; Roos RA; Outeiro TF; Giorgini F; Hollox EJ; the REGISTRY investigators of the European Huntington's Disease Network. "Copy number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease.". (2014): http://europepmc.org/abstract/med/24452335.
  350. Vittori, A.; Breda, C.; Repici, M.; Orth, M.; Roos, R.A.C.; Outeiro, T.F.; Giorgini, F.; Hollox, E.J.. "Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease". Human Molecular Genetics 23 12 (2014): 3129-3137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901308314&partnerID=MN8TOARS.
    10.1093/hmg/ddu022
  351. Yin, G.; Lopes da Fonseca, T.; Eisbach, S.E.; Anduaga, A.M.; Breda, C.; Orcellet, M.L.; Szego, T.M.; et al. "a-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner". Neurobiology of Disease 70 (2014): 149-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904559577&partnerID=MN8TOARS.
    10.1016/j.nbd.2014.06.018
  352. Fonseca-Ornelas, L.; Eisbach, S.E.; Paulat, M.; Giller, K.; Fernández, C.O.; Outeiro, T.F.; Becker, S.; Zweckstetter, M.. "Small molecule-mediated stabilization of vesicle-associated helical a-synuclein inhibits pathogenic misfolding and aggregation". Nature communications 5 (2014): 5857-5857. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930230633&partnerID=MN8TOARS.
    10.1038/ncomms6857
  353. Tenreiro, S.; Eckermann, K.; Outeiro, T.F.. "Protein phosphorylation in neurodegeneration: Friend or foe?". Frontiers in Molecular Neuroscience 7 MAY (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901364520&partnerID=MN8TOARS.
    10.3389/fnmol.2014.00042
  354. Fernandes, J.T.S.; Tenreiro, S.; Gameiro, A.; Chu, V.; Outeiro, T.F.; Conde, J.P.. "Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator". Lab on a Chip 14 20 (2014): 3949-3957. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907809489&partnerID=MN8TOARS.
    10.1039/c4lc00756e
  355. Miller-Fleming, L.; Antas, P.; Pais, T.F.; Smalley, J.L.; Giorgini, F.; Outeiro, T.F.. "Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase". Proceedings of the National Academy of Sciences of the United States of America 111 19 (2014): 7012-7017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900475985&partnerID=MN8TOARS.
    10.1073/pnas.1319221111
  356. Shahpasandzadeh, H.; Popova, B.; Kleinknecht, A.; Fraser, P.E.; Outeiro, T.F.; Braus, G.H.. "Interplay between sumoylation and phosphorylation for protection against a-synuclein inclusions". Journal of Biological Chemistry 289 45 (2014): 31224-31240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84909592222&partnerID=MN8TOARS.
    10.1074/jbc.M114.559237
  357. Tenreiro, S.; Reimão-Pinto, M.M.; Antas, P.; Rino, J.; Wawrzycka, D.; Macedo, D.; Rosado-Ramos, R.; et al. "Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease". PLoS Genetics 10 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901361843&partnerID=MN8TOARS.
    10.1371/journal.pgen.1004302
  358. Lázaro, D.F.; Rodrigues, E.F.; Langohr, R.; Shahpasandzadeh, H.; Ribeiro, T.; Guerreiro, P.; Gerhardt, E.; et al. "Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation". PLoS Genetics 10 11 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84912083676&partnerID=MN8TOARS.
    10.1371/journal.pgen.1004741
  359. Poehler, A.-M.; Xiang, W.; Spitzer, P.; May, V.E.L.; Meixner, H.; Rockenstein, E.; Chutna, O.; et al. "Autophagy modulates SNCA/a-synuclein release, thereby generating a hostile microenvironment". Autophagy 10 12 (2014): 2171-2192. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922364789&partnerID=MN8TOARS.
    10.4161/auto.36436
  360. Zondler, L.; Miller-Fleming, L.; Repici, M.; Gonçalves, S.; Tenreiro, S.; Rosado-Ramos, R.; Betzer, C.; et al. "DJ-1 interactions with a-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease". Cell Death and Disease 5 7 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84905494974&partnerID=MN8TOARS.
    10.1038/cddis.2014.307
  361. Poças, G.M.; Branco-Santos, J.; Herrera, F.; Outeiro, T.F.; Domingos, P.M.. "a-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila". Human Molecular Genetics 24 7 (2014): 1898-1907. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926456769&partnerID=MN8TOARS.
    10.1093/hmg/ddu606
  362. Chutna, O.; Gonçalves, S.; Villar-Piqué, A.; Guerreiro, P.; Marijanovic, Z.; Mendes, T.; Ramalho, J.; et al. "The small GTPase Rab11 co-localizes with a-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity". Human molecular genetics 23 25 (2014): 6732-6745. http://www.scopus.com/inward/record.url?eid=2-s2.0-85005916286&partnerID=MN8TOARS.
    10.1093/hmg/ddu391
  363. Perfeito, R.; Lázaro, D.F.; Outeiro, T.F.; Rego, A.C.. "Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells". Molecular and Cellular Neuroscience 62 (2014): 51-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906751686&partnerID=MN8TOARS.
    10.1016/j.mcn.2014.08.002
  364. Poehler, Anne-Maria; Xiang, Wei; Spitzer, Philipp; May, Verena Elisabeth Luise; Meixner, Holger; Rockenstein, Edward; Chutna, Oldriska; et al. "Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment". Autophagy (2014): https://publons.com/publon/9713523/.
    10.4161/AUTO.36436
  365. Outeiro, Tiago. "Misfolded proteins in Parkinson's disease". European Journal of Neurology (2014): https://publons.com/publon/9713511/.
  366. Perfeito, Rita; Lazar, Diana F.; Outeiro, Tiago F.; Rego, A. Cristina. "Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells". Molecular and Cellular Neuroscience (2014): https://publons.com/publon/9713505/.
    10.1016/J.MCN.2014.08.002
  367. Tenreiro, Sandra; Reimao-Pinto, Madalena M.; Antas, Pedro; Rino, Jose; Wawrzycka, Donata; Macedo, Diana; Rosado-Ramos, Rita; et al. "Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease". PLOS Genetics (2014): https://publons.com/publon/6254382/.
    10.1371/JOURNAL.PGEN.1004302
  368. Fernandes, Joao Tiago S.; Tenreiro, Sandra; Gameiro, Andreia; Chu, Virginia; Outeiro, Tiago F.; Conde, Joao P.. "Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator". Lab on a Chip (2014): https://publons.com/publon/9713503/.
    10.1039/C4LC00756E
  369. Branco dos Santos, J.; Staniforth, G.; Breda, C.; Herrera, F.; Outeiro, T. F.; Tuite, M.; Giorgini, F.. "AGGREGATION-PRONE PROTEINS EXACERBATE HUNTINGTIN TOXICITY IN YEAST AND DROSOPHILA". Journal of Neurology, Neurosurgery & Psychiatry (2014): https://publons.com/publon/7195191/.
    10.1136/JNNP-2014-309032.35
  370. Miller-Fleming, Leonor; Antas, Pedro; Pais, Teresa Faria; Smalley, Joshua L.; Giorgini, Flaviano; Outeiro, Tiago Fleming. "Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase". Proceedings of the National Academy of Sciences (2014): https://publons.com/publon/6157997/.
    10.1073/PNAS.1319221111
  371. Fernandes, Joao Tiago S.; Tenreiro, Sandra; Pedrosa, Catarina R.; Gameiro, Andreia; Chu, Virginia; Outeiro, Tiago F.; Conde, Joao Pedro. "Integration of single cell traps, chemical gradient generator and photosensors in a microfluidic platform for the study of alpha-synuclein toxicity in yeast". Procedia Engineering (2014): https://publons.com/publon/12381864/.
    10.1016/J.PROENG.2014.11.273
  372. Lazaro, Diana F.; Rodrigues, Eva F.; Langohr, Ramona; Shahpasandzadeh, Hedieh; Ribeiro, Thales; Guerreiro, Patricia; Gerhardt, Ellen; et al. "Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation". PLOS Genetics (2014): https://publons.com/publon/3512156/.
    10.1371/JOURNAL.PGEN.1004741
  373. Outeiro, Tiago. "B08 Glycation Modulates Huntingtin Aggregation And Toxicity". Journal of Neurology, Neurosurgery & Psychiatry (2014): https://publons.com/publon/8811207/.
    10.1136/JNNP-2014-309032.36
  374. O. Chutna; S. Goncalves; A. Villar-Pique; P. Guerreiro; Z. Marijanovic; T. Mendes; J. Ramalho; et al. "The small GTPase Rab11 co-localizes with -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity". Human Molecular Genetics (2014): https://publons.com/publon/4040441/.
    10.1093/HMG/DDU391
  375. Outeiro, Tiago. "B06 Exploring The Role Of Phosphorylation In Huntingtin Aggregation Dynamics". Journal of Neurology, Neurosurgery & Psychiatry (2014): https://publons.com/publon/7195192/.
    10.1136/JNNP-2014-309032.34
  376. Outeiro, Tiago. "Protein phosphorylation in neurodegeneration: friend or foe?". Frontiers in Molecular Neuroscience (2014): https://publons.com/publon/5958/.
    10.3389/FNMOL.2014.00042
  377. Outeiro, Tiago. "DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease". Human Molecular Genetics (2014): https://publons.com/publon/6158004/.
    10.1093/HMG/DDT466
  378. Outeiro, Tiago. "MeCP2: a novel Huntingtin interactor". Human Molecular Genetics (2014): https://publons.com/publon/9713506/.
    10.1093/HMG/DDT499
  379. Yin, Guowei; Da Fonseca, Tomas Lopes; Eisbach, Sibylle E.; Anduaga, Ane Martin; Breda, Carlo; Orcellet, Maria L.; Szego, Eva M.; et al. "alpha-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner". Neurobiology of Disease (2014): https://publons.com/publon/7332446/.
    10.1016/J.NBD.2014.06.018
  380. Outeiro, Tiago. "Interplay between Sumoylation and Phosphorylation for Protection against a-Synuclein Inclusions". Journal of Biological Chemistry (2014): https://publons.com/publon/9713521/.
    10.1074/JBC.M114.559237
  381. Outeiro, Tiago. "DJ-1 interactions with a-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease". Cell Death and Disease (2014): https://publons.com/publon/6157970/.
    10.1038/CDDIS.2014.307
  382. Outeiro, Tiago. "Small molecule-mediated stabilization of vesicle-associated helical a-synuclein inhibits pathogenic misfolding and aggregation". Nature Communications (2014): https://publons.com/publon/9713522/.
    10.1038/NCOMMS6857
  383. Outeiro, Tiago. "Challenges and Promises in the Development of Neurotrophic Factor-Based Therapies for Parkinson’s Disease". Drugs & Aging (2014): https://publons.com/publon/9713508/.
    10.1007/S40266-014-0160-X
  384. Outeiro, Tiago. "Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease". Human Molecular Genetics (2014): https://publons.com/publon/9713504/.
    10.1093/HMG/DDU022
  385. Vittori A; Orth M; Roos RA; Outeiro TF; Giorgini F; Hollox EJ; REGISTRY investigators of the European Huntington’s Disease Network. "ß-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease.". (2013): http://europepmc.org/abstract/med/24587836.
  386. Donmez, G.; Outeiro, T.F.. "SIRT1 and SIRT2: Emerging targets in neurodegeneration". EMBO Molecular Medicine 5 3 (2013): 344-352. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874709843&partnerID=MN8TOARS.
    10.1002/emmm.201302451
  387. Gonçalves, S.; Outeiro, T.F.. "Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy". Molecular Neurobiology (2013): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873386378&partnerID=MN8TOARS.
    10.1007/s12035-013-8406-x
  388. Szego, É.M.; Outeiro, T.F.; Kermer, P.; Schulz, J.B.. "Impairment of the septal cholinergic neurons in MPTP-treated A30P a-synuclein mice". Neurobiology of Aging 34 2 (2013): 589-601. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869091501&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2012.04.012
  389. Lopes da Fonseca, T.; Correia, A.; Hasselaar, W.; van der Linde, H.C.; Willemsen, R.; Outeiro, T.F.. "The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival". Brain Research Bulletin 90 1 (2013): 118-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870495284&partnerID=MN8TOARS.
    10.1016/j.brainresbull.2012.09.017
  390. Repici, M.; Straatman, K.R.; Balduccio, N.; Enguita, F.J.; Outeiro, T.F.; Giorgini, F.. "Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells". Journal of Molecular Medicine 91 5 (2013): 599-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879076109&partnerID=MN8TOARS.
    10.1007/s00109-012-0976-y
  391. Amaral, M.; Levy, C.; Heyes, D.J.; Lafite, P.; Outeiro, T.F.; Giorgini, F.; Leys, D.; Scrutton, N.S.. "Structural basis of kynurenine 3-monooxygenase inhibition". Nature 496 7445 (2013): 382-385. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876286750&partnerID=MN8TOARS.
    10.1038/nature12039
  392. Guerreiro, P.S.; Huang, Y.; Gysbers, A.; Cheng, D.; Gai, W.P.; Outeiro, T.F.; Halliday, G.M.. "LRRK2 interactions with a-synuclein in Parkinson's disease brains and in cell models". Journal of Molecular Medicine 91 4 (2013): 513-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879602725&partnerID=MN8TOARS.
    10.1007/s00109-012-0984-y
  393. Amaral, J.D.; Herrera, F.; Rodrigues, P.M.; Dionísio, P.A.; Outeiro, T.F.; Rodrigues, C.M.P.. "Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system". Biochemical Pharmacology 85 6 (2013): 745-752. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874114339&partnerID=MN8TOARS.
    10.1016/j.bcp.2012.12.009
  394. Gonçalves, S.; Outeiro, T.F.. "Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.". Molecular neurobiology 47 3 (2013): 1081-1092. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887273441&partnerID=MN8TOARS.
  395. Amaral, M.; Outeiro, T.F.; Scrutton, N.S.; Giorgini, F.. "The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease". Journal of Molecular Medicine 91 6 (2013): 705-713. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878618542&partnerID=MN8TOARS.
    10.1007/s00109-013-1046-9
  396. Faria, C.; Jorge, C.D.; Borges, N.; Tenreiro, S.; Outeiro, T.F.; Santos, H.. "Inhibition of formation of a-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease". Biochimica et Biophysica Acta - General Subjects 1830 8 (2013): 4065-4072. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877839143&partnerID=MN8TOARS.
    10.1016/j.bbagen.2013.04.015
  397. Schildknecht, S.; Gerding, H.R.; Karreman, C.; Drescher, M.; Lashuel, H.A.; Outeiro, T.F.; Di Monte, D.A.; Leist, M.. "Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: Implications for disease mechanisms and interventions in synucleinopathies". Journal of Neurochemistry 125 4 (2013): 491-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876790040&partnerID=MN8TOARS.
    10.1111/jnc.12226
  398. Pais, T.F.; Szego, É.M.; Marques, O.; Miller-Fleming, L.; Antas, P.; Guerreiro, P.; De Oliveira, R.M.; Kasapoglu, B.; Outeiro, T.F.. "The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation". EMBO Journal 32 19 (2013): 2603-2616. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885173084&partnerID=MN8TOARS.
    10.1038/emboj.2013.200
  399. Miranda, H.V.; Xiang, W.; De Oliveira, R.M.; Simões, T.; Pimentel, J.; Klucken, J.; Penque, D.; Outeiro, T.F.. "Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications". Journal of Neurochemistry 126 5 (2013): 673-684. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883177285&partnerID=MN8TOARS.
    10.1111/jnc.12251
  400. Taschenberger, G.; Toloe, J.; Tereshchenko, J.; Akerboom, J.; Wales, P.; Benz, R.; Becker, S.; et al. "ß-synuclein aggregates and induces neurodegeneration in dopaminergic neurons". Annals of Neurology 74 1 (2013): 109-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883279162&partnerID=MN8TOARS.
    10.1002/ana.23905
  401. Eisbach, S.E.; Outeiro, T.F.. "Alpha-Synuclein and intracellular trafficking: Impact on the spreading of Parkinson's disease pathology". Journal of Molecular Medicine 91 6 (2013): 693-703. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878614977&partnerID=MN8TOARS.
    10.1007/s00109-013-1038-9
  402. Marques S; Outeiro TF. "Epigenetics in Parkinson's and Alzheimer's diseases.". (2013): http://europepmc.org/abstract/med/23150265.
    10.1007/978-94-007-4525-4_22
  403. Wales P; Pinho R; Lázaro DF; Outeiro TF. "Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.". (2013): http://europepmc.org/abstract/med/24270242.
    10.3233/JPD-130216
  404. Fagerqvist, T.; Näsström, T.; Ihse, E.; Lindström, V.; Sahlin, C.; Fangmark Tucker, S.M.; Kasaryan, A.; et al. "Off-pathway a-synuclein oligomers seem to alter a-synuclein turnover in a cell model but lack seeding capability in vivo". Amyloid 20 4 (2013): 233-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888053160&partnerID=MN8TOARS.
    10.3109/13506129.2013.835726
  405. Basso, E.; Antas, P.; Marijanovic, Z.; Gonçalves, S.; Tenreiro, S.; Outeiro, T.F.. "PLK2 modulates a-synuclein aggregation in yeast and mammalian cells". Molecular Neurobiology 48 3 (2013): 854-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888000967&partnerID=MN8TOARS.
    10.1007/s12035-013-8473-z
  406. Tenreiro, S.; Munder, M.C.; Alberti, S.; Outeiro, T.F.. "Harnessing the power of yeast to unravel the molecular basis of neurodegeneration". Journal of Neurochemistry 127 4 (2013): 438-452. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887107990&partnerID=MN8TOARS.
    10.1111/jnc.12271
  407. Vittori, A.; Orth, M.; Roos, R.A.C.; Outeiro, T.F.; Giorgini, F.; Hollox, E.J.; Bachoud-Lévi, A.-C.; et al. "ß-defensin genomic copy number does not influence the age of onset in huntington’s disease". Journal of Huntington's Disease 2 1 (2013): 107-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906932590&partnerID=MN8TOARS.
    10.3233/JHD-130047
  408. Macedo, Diana; Tavares, Lucelia; McDougall, Gordon J.; Stewart, Derek; Ferreira, Ricardo B.; Outeiro, Tiago F.; Santos, Claudia N.; Tenreiro, Sandra. "Polyphenols protect from alpha-synuclein toxicity by increasing autophagy and reducing reactive oxygen species in a yeast model of Parkinson's disease". Yeast (2013): https://publons.com/publon/7124406/.
  409. Guerreiro, Patricia Silva; Huang, Yue; Gysbers, Amanda; Cheng, Danni; Gai, Wei Ping; Outeiro, Tiago Fleming; Halliday, Glenda Margaret. "LRRK2 interactions with alpha-synuclein in Parkinson's disease brains and in cell models". Journal of Molecular Medicine (2013): https://publons.com/publon/7145143/.
    10.1007/S00109-012-0984-Y
  410. Vicente Miranda, Hugo; Xiang, Wei; de Oliveira, Rita M.; Simoes, Tania; Pimentel, Jose; Klucken, Jochen; Penque, Deborah; Outeiro, Tiago F.. "Heat-mediated enrichment of alpha-synuclein from cells and tissue for assessing post-translational modifications". Journal of Neurochemistry (2013): https://publons.com/publon/5409607/.
    10.1111/JNC.12251
  411. Outeiro, Tiago. "Caffeine and adenosine receptor controlling stress activated pathways: a window for depression". Journal of Neurochemistry (2013): https://publons.com/publon/9548817/.
  412. Pais, Teresa Faria; Szego, Eva M.; Marques, Oldriska; Miller-Fleming, Leonor; Antas, Pedro; Guerreiro, Patricia; de Oliveira, Rita Machado; Kasapoglu, Burcu; Outeiro, Tiago Fleming. "The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation". The EMBO Journal (2013): https://publons.com/publon/6157967/.
    10.1038/EMBOJ.2013.200
  413. Donmez, Gizem; Outeiro, Tiago F.. "SIRT1 and SIRT2: emerging targets in neurodegeneration". EMBO Molecular Medicine (2013): https://publons.com/publon/9713542/.
    10.1002/EMMM.201302451
  414. Outeiro, Tiago. "PLK2 Modulates a-Synuclein Aggregation in Yeast and Mammalian Cells". Molecular Neurobiology (2013): https://publons.com/publon/9516977/.
    10.1007/S12035-013-8473-Z
  415. Tenreiro, Sandra; Reimao-Pinto, Madalena M.; Antas, Pedro; Rino, Jose; Waiss, Meytal; Magalhaes, Filipa; Wawrzycka, Donata; et al. "Harnessing the power of yeast to decipher the role of alpha-synuclein phosphorylation in Parkinson's disease". Yeast (2013): https://publons.com/publon/7124394/.
  416. Outeiro, Tiago. "ß-synuclein aggregates and induces neurodegeneration in dopaminergic neurons". Annals of Neurology (2013): https://publons.com/publon/9713529/.
    10.1002/ANA.23905
  417. Repici, Mariaelena; Straatman, Kornelis R.; Balduccio, Nadia; Enguita, Francisco J.; Outeiro, Tiago F.; Giorgini, Flaviano. "Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells". Journal of Molecular Medicine (2013): https://publons.com/publon/9532804/.
    10.1007/S00109-012-0976-Y
  418. Amaral, Marta; Outeiro, Tiago F.; Scrutton, Nigel S.; Giorgini, Flaviano. "The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease". Journal of Molecular Medicine (2013): https://publons.com/publon/9713528/.
    10.1007/S00109-013-1046-9
  419. Outeiro, Tiago. "Harnessing the power of yeast to unravel the molecular basis of neurodegeneration". Journal of Neurochemistry (2013): https://publons.com/publon/6939907/.
    10.1111/JNC.12271
  420. Faria, Cristiana; Jorge, Carla D.; Borges, Nuno; Tenreiro, Sandra; Outeiro, Tiago F.; Santos, Helena. "Inhibition of formation of alpha-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - General Subjects (2013): https://publons.com/publon/9713534/.
    10.1016/J.BBAGEN.2013.04.015
  421. Eisbach, Sibylle E.; Outeiro, Tiago F.. "alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology". Journal of Molecular Medicine (2013): https://publons.com/publon/9713532/.
    10.1007/S00109-013-1038-9
  422. Outeiro, Tiago. "Impairment of the septal cholinergic neurons in MPTP-treated A30P a-synuclein mice". Neurobiology of Aging (2013): https://publons.com/publon/9713541/.
    10.1016/J.NEUROBIOLAGING.2012.04.012
  423. da Fonseca, Tomas Lopes; Correia, Ana; Hasselaar, Wiebren; van der Linde, Herma C.; Willemsen, Rob; Outeiro, Tiago Fleming. "The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival". Brain Research Bulletin (2013): https://publons.com/publon/9713543/.
    10.1016/J.BRAINRESBULL.2012.09.017
  424. Outeiro, Tiago. "Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system". Biochemical Pharmacology (2013): https://publons.com/publon/3314607/.
    10.1016/J.BCP.2012.12.009
  425. Outeiro, Tiago. "Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy". Molecular Neurobiology (2013): https://publons.com/publon/9713530/.
    10.1007/S12035-013-8406-X
  426. Outeiro, Tiago. "Structural basis of kynurenine 3-monooxygenase inhibition". Nature (2013): https://publons.com/publon/5063753/.
    10.1038/NATURE12039
  427. Stefan Schildknecht; Hanne R. Gerding; Christiaan Karreman; Malte Drescher; Hilal A. Lashuel; Tiago F. Outeiro; Donato A. Di Monte; Marcel Leist. "Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies". Journal of Neurochemistry (2013): https://publons.com/publon/4086269/.
    10.1111/JNC.12226
  428. Herrera, F.; Gonalves, S.; Outeiro, T.F.. "Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation". Methods in Enzymology 506 (2012): 157-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857351293&partnerID=MN8TOARS.
    10.1016/B978-0-12-391856-7.00033-0
  429. Herrera, F.; Outeiro, T.F.. "a-Synuclein modifies huntingtin aggregation in living cells". FEBS Letters 586 1 (2012): 7-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84655176749&partnerID=MN8TOARS.
    10.1016/j.febslet.2011.11.019
  430. Kemppainen, S.; Rantamäki, T.; Jerónimo-Santos, A.; Lavasseur, G.; Autio, H.; Karpova, N.; Kärkkäinen, E.; et al. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice". Neurobiology of Aging 33 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859486324&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2011.11.006
  431. Sancenon, V.; Lee, S.-A.; Patrick, C.; Griffith, J.; Paulino, A.; Outeiro, T.F.; Reggiori, F.; Masliah, E.; Muchowski, P.J.. "Suppression of a-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context". Human Molecular Genetics 21 11 (2012): 2432-2449. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861144992&partnerID=MN8TOARS.
    10.1093/hmg/dds058
  432. Gonçalves, S.; Miranda, H.V.; Outeiro, T.F.. "Novel Molecular Therapeutics in Parkinson's Disease". Molecular and Cellular Therapeutics (2012): 245-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886037660&partnerID=MN8TOARS.
    10.1002/9781119967309.ch11
  433. Rosa, P.; Tenreiro, S.; Chu, V.; Outeiro, T.F.; Conde, J.P.. "High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment". Biomicrofluidics 6 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859318117&partnerID=MN8TOARS.
    10.1063/1.3683161
  434. Diógenes, M.J.; Dias, R.B.; Rombo, D.M.; Miranda, H.V.; Maiolino, F.; Guerreiro, P.; Näsström, T.; et al. "Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation". Journal of Neuroscience 32 34 (2012): 11750-11762. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865202477&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.0234-12.2012
  435. Petroi, D.; Popova, B.; Taheri-Talesh, N.; Irniger, S.; Shahpasandzadeh, H.; Zweckstetters, M.; Outeiro, T.F.; Braus, G.H.. "Aggregate clearance of a-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome". Journal of Biological Chemistry 287 33 (2012): 27567-27579. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864979359&partnerID=MN8TOARS.
    10.1074/jbc.M112.361865
  436. Marques, O.; Outeiro, T.F.. "Alpha-synuclein: From secretion to dysfunction and death". Cell Death and Disease 3 7 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84864870837&partnerID=MN8TOARS.
    10.1038/cddis.2012.94
  437. Maxwell, M.M.; Zaldivar-Jolissaint, J.F.; Mai, A.; Outeiro, T.F.; Kazanstev, A.G.. "Highlights of the Keystone Symposium: Sirtuins in metabolism, aging and disease". EMBO Molecular Medicine 4 7 (2012): 557-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863480943&partnerID=MN8TOARS.
    10.1002/emmm.201201452
  438. Sampaio-Marques, B.; Felgueiras, C.; Silva, A.; Rodrigues, M.; Tenreiro, S.; Franssens, V.; Reichert, A.S.; et al. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy". Autophagy 8 10 (2012): 1494-1509. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867280590&partnerID=MN8TOARS.
    10.4161/auto.21275
  439. Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F.. "Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice". Neuroscience 220 (2012): 256-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864770859&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2012.06.029
  440. de Oliveira, R.M.; Sarkander, J.; Kazantsev, A.G.; Outeiro, T.F.. "SIRT2 as a therapeutic target for age-related disorders". Frontiers in Pharmacology 3 MAY (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866013044&partnerID=MN8TOARS.
    10.3389/fphar.2012.00082
  441. Kazantsev, A.G.; Outeiro, T.F.. "Editorial on special topic: Sirtuins in metabolism, aging, and disease". Frontiers in Pharmacology 3 APR (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866047359&partnerID=MN8TOARS.
    10.3389/fphar.2012.00071
  442. Maxwell, Michele M.; Zaldivar-Jolissaint, Julien Francisco; Mai, Antonello; Outeiro, Tiago F.; Kazanstev, Aleksey G.. "Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease". EMBO Molecular Medicine (2012): https://publons.com/publon/9713545/.
    10.1002/EMMM.201201452
  443. Outeiro, Tiago. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice". Neurobiology of Aging (2012): https://publons.com/publon/8811204/.
    10.1016/J.NEUROBIOLAGING.2011.11.006
  444. Outeiro, Tiago. "Suppression of -synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context". Human Molecular Genetics (2012): https://publons.com/publon/9713544/.
    10.1093/HMG/DDS058
  445. Outeiro, Tiago. "Insulin resistance is associated with reduced levels of the age-related protein SIRT2". The FASEB Journal (2012): https://publons.com/publon/9713525/.
  446. Outeiro, Tiago. "B10 The role of n-terminal phosphorylation in huntingtin's oligomerisation, aggregation and toxicity". Journal of Neurology, Neurosurgery & Psychiatry (2012): https://publons.com/publon/7195185/.
    10.1136/JNNP-2012-303524.26
  447. Outeiro, Tiago. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy". Autophagy (2012): https://publons.com/publon/3193430/.
    10.4161/AUTO.21275
  448. Outeiro, Tiago. "Editorial on Special Topic: Sirtuins in Metabolism, Aging, and Disease". Frontiers in Pharmacology (2012): https://publons.com/publon/9713527/.
    10.3389/FPHAR.2012.00071
  449. Outeiro, Tiago. "Alpha-synuclein: from secretion to dysfunction and death". Cell Death and Disease (2012): https://publons.com/publon/9713546/.
    10.1038/CDDIS.2012.94
  450. Marques, S. C. F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonca, A.; Santana, I.; Outeiro, T. F.; Pereira, C. M. F.. "EPIGENETIC REGULATION OF BACE1 IN ALZHEIMER'S DISEASE PATIENTS AND IN TRANSGENIC MICE". Neuroscience (2012): https://publons.com/publon/6933110/.
    10.1016/J.NEUROSCIENCE.2012.06.029
  451. Outeiro, Tiago. "Aggregate Clearance of alpha-Synuclein in Saccharomyces cerevisiae Depends More on Autophagosome and Vacuole Function Than on the Proteasome". Journal of Biological Chemistry (2012): https://publons.com/publon/9713548/.
    10.1074/JBC.M112.361865
  452. Outeiro, Tiago. "SIRT2 as a Therapeutic Target for Age-Related Disorders". Frontiers in Pharmacology (2012): https://publons.com/publon/19182/.
    10.3389/FPHAR.2012.00082
  453. Outeiro, Tiago. "alpha-Synuclein modifies huntingtin aggregation in living cells". FEBS Letters (2012): https://publons.com/publon/7195183/.
    10.1016/J.FEBSLET.2011.11.019
  454. Maxwell, Michele M.; Zaldivar-Jolissaint, Julien Francisco; Mai, Antonello; Outeiro, Tiago F.; Kazantsev, Aleksey G.. "Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease. (vol 4, pg 557, 2012)". EMBO Molecular Medicine (2012): https://publons.com/publon/9713547/.
    10.1002/EMMM.201290007
  455. Tauber, E.; Miller-Fleming, L.; Mason, R.P.; Kwan, W.; Clapp, J.; Butler, N.J.; Outeiro, T.F.; Muchowski, P.J.; Giorgini, F.. "Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity". Journal of Biological Chemistry 286 1 (2011): 410-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650937295&partnerID=MN8TOARS.
    10.1074/jbc.M110.101527
  456. Jorge, C.D.; Ventura, R.; Maycock, C.; Outeiro, T.F.; Santos, H.; Costa, J.. "Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases". Neurochemical Research 36 6 (2011): 1005-1011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955681334&partnerID=MN8TOARS.
    10.1007/s11064-011-0440-3
  457. Marques, S.C.F.; Pereira, C.M.F.; Outeiro, T.F.. "Epigenetics and neurodegeneration: Unveiling the complexity". Bio Tech International 23 JUNE (2011): 16-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960753413&partnerID=MN8TOARS.
  458. Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F.. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry 35 2 (2011): 348-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952900959&partnerID=MN8TOARS.
    10.1016/j.pnpbp.2010.08.008
  459. Hansen, C.; Angot, E.; Bergström, A.-L.; Steiner, J.A.; Pieri, L.; Paul, G.; Outeiro, T.F.; et al. "a-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells". Journal of Clinical Investigation 121 2 (2011): 715-725. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551519276&partnerID=MN8TOARS.
    10.1172/JCI43366
  460. Martins, M.; Rosa, A.; Guedes, L.C.; Fonseca, B.V.; Gotovac, K.; Violante, S.; Mestre, T.; et al. "Convergence of mirna expression profiling, a-synuclein interacton and GWAS in Parkinson's disease". PLoS ONE 6 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053925209&partnerID=MN8TOARS.
    10.1371/journal.pone.0025443
  461. Swinnen, E.; Büttner, S.; Outeiro, T.F.; Galas, M.-C.; Madeo, F.; Winderickx, J.; Franssens, V.. "Aggresome formation and segregation of inclusions influence toxicity of a-synuclein and synphilin-1 in yeast". Biochemical Society Transactions 39 5 (2011): 1476-1481. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053372157&partnerID=MN8TOARS.
    10.1042/BST0391476
  462. Outeiro, T.F.. "Amyloidogenesis: FlAsH illuminates Aß aggregation". Nature Chemical Biology 7 9 (2011): 581-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860400257&partnerID=MN8TOARS.
    10.1038/nchembio.636
  463. de Oliveira, R.M.; Marijanovic, Z.; Carvalho, F.; Miltényi, G.M.; Matos, J.E.; Tenreiro, S.; Oliveira, S.; et al. "Impaired proteostasis contributes to renal tubular dysgenesis". PLoS ONE 6 6 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79958288631&partnerID=MN8TOARS.
    10.1371/journal.pone.0020854
  464. Herrera, F.; Tenreiro, S.; Miller-Fleming, L.; Outeiro, T.F.. "Visualization of cell-to-cell transmission of mutant huntingtin oligomers". PLoS Currents (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866322000&partnerID=MN8TOARS.
    10.1371/currents.RRN1210
  465. Szego, E.M.; Gerhardt, E.; Outeiro, T.F.; Kermer, P.. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences 310 1-2 (2011): 90-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054111618&partnerID=MN8TOARS.
    10.1016/j.jns.2011.06.048
  466. Näsström, T.; Gonçalves, S.; Sahlin, C.; Nordström, E.; Sundquist, V.S.; Lannfelt, L.; Bergström, J.; Outeiro, T.F.; Ingelsson, M.. "Antibodies against alpha-synuclein reduce oligomerization in living cells". PLoS ONE 6 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80055113204&partnerID=MN8TOARS.
    10.1371/journal.pone.0027230
  467. Badiola, N.; de Oliveira, R.M.; Herrera, F.; Guardia-Laguarta, C.; Gonçalves, S.A.; Pera, M.; Suárez-Calvet, M.; et al. "Tau enhances a-synuclein aggregation and toxicity in cellular models of synucleinopathy". PLoS ONE 6 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80055079219&partnerID=MN8TOARS.
    10.1371/journal.pone.0026609
  468. Marques S; Batalha VL; Lopes LV; Outeiro TF. "Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.". (2011): http://europepmc.org/abstract/med/21427489.
    10.3233/JAD-2011-110032
  469. Gerhardt, E.; Gräber, S.; Szego, E.M.; Moisoi, N.; Martins, L.M.; Outeiro, T.F.; Kermer, P.. "Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice". PLoS ONE 6 12 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-83655183720&partnerID=MN8TOARS.
    10.1371/journal.pone.0028855
  470. Ribeiro Morais, G.; Vicente Miranda, H.; Santos, I.C.; Santos, I.; Outeiro, T.F.; Paulo, A.. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic and Medicinal Chemistry 19 24 (2011): 7698-7710. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255178997&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.09.065
  471. Outeiro, Tiago. "Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity". Journal of Biological Chemistry (2011): https://publons.com/publon/5126043/.
    10.1074/JBC.M110.101527
  472. Jorge, Carla D.; Ventura, Rita; Maycock, Christopher; Outeiro, Tiago F.; Santos, Helena; Costa, Julia. "Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington's and Parkinson's Diseases". Neurochemical Research (2011): https://publons.com/publon/8217541/.
    10.1007/S11064-011-0440-3
  473. Outeiro, Tiago. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences (2011): https://publons.com/publon/9713533/.
    10.1016/J.JNS.2011.06.048
  474. Outeiro, Tiago. "Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells". Plos One (2011): https://publons.com/publon/9713531/.
    10.1371/JOURNAL.PONE.0027230
  475. Outeiro, Tiago. "FlAsH illuminates Aß aggregation". Nature Chemical Biology (2011): https://publons.com/publon/9713536/.
    10.1038/NCHEMBIO.636
  476. Outeiro, Tiago. "A stem-cell ageing hypothesis on the origin of Parkinson's disease". Journal of Neurology (2011): https://publons.com/publon/9713539/.
  477. Outeiro, Tiago. "Impaired Proteostasis Contributes to Renal Tubular Dysgenesis". Plos One (2011): https://publons.com/publon/9206785/.
    10.1371/JOURNAL.PONE.0020854
  478. Outeiro, Tiago. "Synaptic Dysfunction in Parkinson's Disease: From Protein Misfolding to Functional Alterations". Folding for the Synapse (2011): https://publons.com/publon/16533551/.
    10.1007/978-1-4419-7061-9_13
  479. Outeiro, Tiago. "SIRTUINS: A NOVEL LINK BETWEEN NEUROIFLAMMATION AND NEURODEGENERATION". Glia (2011): https://publons.com/publon/9713537/.
  480. Correia Guedes, L.; Lobo, P.; Valadas, A.; Neutel, D.; Mestre, T.; Coelho, M.; Rosa, M. M.; et al. "Non-motor symptoms in Portuguese Parkinson's disease patients". Movement Disorders (2011): https://publons.com/publon/9713535/.
  481. Outeiro, Tiago. "SIRT2 is downregulated in insulin-resistant HepG2 cells: a possible role of oxidative stress.". Molecular Biology of the Cell (2011): https://publons.com/publon/9713554/.
  482. Ellen Gerhardt; Simone Gräber; Éva M. Szego; Nicoleta Moisoi; L. Miguel Martins; Tiago F. Outeiro; Pawel Kermer. "Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice". Plos One (2011): https://publons.com/publon/9713526/.
    10.1371/JOURNAL.PONE.0028855
  483. Morais, Goreti Ribeiro; Vicente Miranda, Hugo; Santos, Isabel C.; Santos, Isabel; Outeiro, Tiago F.; Paulo, Antonio. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic & Medicinal Chemistry (2011): https://publons.com/publon/8811205/.
    10.1016/J.BMC.2011.09.065
  484. Martins, Madalena; Rosa, Alexandra; Guedes, Leonor C.; Fonseca, Benedita V.; Gotovac, Kristina; Violante, Sara; Mestre, Tiago; et al. "Convergence of miRNA Expression Profiling, alpha-Synuclein Interacton and GWAS in Parkinson's Disease". Plos One (2011): https://publons.com/publon/29642/.
    10.1371/JOURNAL.PONE.0025443
  485. Marques, Sueli C. F.; Oliveira, Catarina R.; Pereira, Claudia M. F.; Outeiro, Tiago F.. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry (2011): https://publons.com/publon/6041261/.
    10.1016/J.PNPBP.2010.08.008
  486. Badiola, Nahuai; de Oliveira, Rita Machado; Herrera, Federico; Guardia-Laguarta, Cristina; Goncalves, Susana A.; Pera, Marta; Suarez-Calvet, Marc; et al. "Tau Enhances alpha-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy". Plos One (2011): https://publons.com/publon/6846882/.
    10.1371/JOURNAL.PONE.0026609
  487. Kazantsev AG; Outeiro TF. "Drug discovery for CNS disorders: from bench to bedside.". (2010): http://europepmc.org/abstract/med/20942783.
    10.2174/187152710793237395
  488. Diógenes MJ; Outeiro TF. "Neurotrophic factors as a protective strategy in Parkinson's disease.". (2010): http://europepmc.org/abstract/med/20942787.
    10.2174/187152710793237449
  489. de Oliveira RM; Pais TF; Outeiro TF. "Sirtuins: common targets in aging and in neurodegeneration.". (2010): http://europepmc.org/abstract/med/20840069.
    10.2174/1389450111007011270
  490. Tenreiro, S.; Outeiro, T.F.. "Simple is good: Yeast models of neurodegeneration". FEMS Yeast Research 10 8 (2010): 970-979. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349294528&partnerID=MN8TOARS.
    10.1111/j.1567-1364.2010.00649.x
  491. Kazantsev, A.G.; Outeiro, T.F.. "Drug discovery for cns disorders: From bench to bedside". CNS and Neurological Disorders - Drug Targets 9 6 (2010): 668-668. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649337104&partnerID=MN8TOARS.
  492. Diógenes, M.J.; Outeiro, T.F.. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets 9 6 (2010): 754-763. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649251977&partnerID=MN8TOARS.
  493. Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F.. "Alzheimer's disease: The quest to understand complexity". Journal of Alzheimer's Disease 21 2 (2010): 373-383. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957352488&partnerID=MN8TOARS.
    10.3233/JAD-2010-100303
  494. da Costa, G.; Guerreiro, A.; Correia, C.F.; Gomes, R.J.; Freire, A.; Monteiro, E.; Barroso, E.; et al. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics - Clinical Applications 4 6-7 (2010): 674-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955783949&partnerID=MN8TOARS.
    10.1002/prca.200900118
  495. Miranda, H.V.; Outeiro, T.F.. "The sour side of neurodegenerative disorders: The effects of protein glycation". Journal of Pathology 221 1 (2010): 13-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950989148&partnerID=MN8TOARS.
    10.1002/path.2682
  496. Su, L.J.; Auluck, P.K.; Outeiro, T.F.; Yeger-Lotem, E.; Kritzer, J.A.; Tardiff, D.F.; Strathearn, K.E.; et al. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". DMM Disease Models and Mechanisms 3 3-4 (2010): 194-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949438990&partnerID=MN8TOARS.
    10.1242/dmm.004267
  497. Büttner, S.; Delay, C.; Franssens, V.; Bammens, T.; Ruli, D.; Zaunschirm, S.; de Oliveira, R.M.; et al. "Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a sir2-dependent manner". PLoS ONE 5 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78149449581&partnerID=MN8TOARS.
    10.1371/journal.pone.0013700
  498. Gonçalves, S.A.; Matos, J.E.; Outeiro, T.F.. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences 35 11 (2010): 643-651. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049259996&partnerID=MN8TOARS.
    10.1016/j.tibs.2010.05.007
  499. Nakhjavani, M.; Morteza, A.; Khajeali, L.; Esteghamati, A.; Khalilzadeh, O.; Asgarani, F.; Outeiro, T.F.. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones 15 6 (2010): 959-964. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149434868&partnerID=MN8TOARS.
    10.1007/s12192-010-0204-z
  500. de Oliveira, R.M.; Pais, T.F.; Outeiro, T.F.. "Irtuins: Common targets in aging and in neurodegeneration". Current Drug Targets 11 10 (2010): 1270-1280. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958001297&partnerID=MN8TOARS.
  501. Nakhjavani, Manouchehr; Morteza, Afsaneh; Khajeali, Leila; Esteghamati, Alireza; Khalilzadeh, Omid; Asgarani, Firouzeh; Outeiro, Tiago F.. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones (2010): https://publons.com/publon/7283830/.
    10.1007/S12192-010-0204-Z
  502. Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F.. "Epigenetics and Neurodegeneration: A Connection Overlooked". Epigenetics: Mechanism, Functions and Human Effects (2010): https://publons.com/publon/12719845/.
  503. Outeiro, Tiago. "B07 Identification of protein interaction partners for kynurenine 3-monooxygenase, a candidate therapeutic target for Huntington's disease". Journal of Neurology, Neurosurgery & Psychiatry (2010): https://publons.com/publon/9713564/.
    10.1136/JNNP.2010.222596.7
  504. Outeiro, Tiago. "The sour side of neurodegenerative disorders: the effects of protein glycation". The Journal of Pathology (2010): https://publons.com/publon/8811201/.
    10.1002/PATH.2682
  505. Outeiro, Tiago. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". Disease Models & Mechanisms (2010): https://publons.com/publon/9713562/.
    10.1242/DMM.004267
  506. Outeiro, Tiago. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics – Clinical Applications (2010): https://publons.com/publon/9713563/.
    10.1002/PRCA.200900118
  507. Outeiro, Tiago. "Simple is good: yeast models of neurodegeneration". FEMS Yeast Research (2010): https://publons.com/publon/9713559/.
    10.1111/J.1567-1364.2010.00649.X
  508. Outeiro, Tiago. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences (2010): https://publons.com/publon/9713566/.
    10.1016/J.TIBS.2010.05.007
  509. Outeiro, Tiago. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets (2010): https://publons.com/publon/9713560/.
  510. Outeiro, Tiago. "Drug discovery for CNS disorders: from bench to bedside". CNS and Neurological Disorders - Drug Targets (2010): https://publons.com/publon/9713556/.
  511. Buettner, Sabrina; Delay, Charlotte; Franssens, Vanessa; Bammens, Tine; Ruli, Doris; Zaunschirm, Sandra; de Oliveira, Rita Machado; et al. "Synphilin-1 Enhances alpha-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner". Plos One (2010): https://publons.com/publon/5601618/.
    10.1371/JOURNAL.PONE.0013700
  512. Outeiro, T.F.; Ferreira, J.. "Current and future therapeutic strategies for Parkinson's disease". Current Pharmaceutical Design 15 34 (2009): 3968-3976. http://www.scopus.com/inward/record.url?eid=2-s2.0-70649115523&partnerID=MN8TOARS.
    10.2174/138161209789649321
  513. Da Costa, G.; Gomes, R.; Correia, C.F.; Freire, A.; Monteiro, E.; Martins, A.; Barroso, E.; et al. "Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry". Amyloid 16 4 (2009): 201-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-73349118440&partnerID=MN8TOARS.
    10.3109/13506120903421561
  514. Outeiro TF; Klucken J; Bercury K; Tetzlaff J; Putcha P; Oliveira LM; Quintas A; McLean PJ; Hyman BT. "Dopamine-induced conformational changes in alpha-synuclein.". (2009): http://europepmc.org/abstract/med/19730729.
    10.1371/journal.pone.0006906
  515. Outeiro, Tiago. "Dopamine-Induced Conformational Changes in Alpha-Synuclein". Plos One (2009): https://publons.com/publon/9713568/.
    10.1371/JOURNAL.PONE.0006906
  516. Outeiro, Tiago. "Intracellular signaling - cellular models to investigate alpha-synuclein function and dysfunction". Journal of Neurochemistry (2009): https://publons.com/publon/9713573/.
  517. Oldriska, Marques; Oliveira Rita, M.; Ferreira, Moita Luis; Fleming, Outeiro Tiago. "Sirtuins as a link between ageing and neurodegeneration". New Trends in Alzheimer and Parkinson Related Disorders: ADPD (2009): https://publons.com/wos-op/publon/12263479/.
  518. Outeiro, T.F.. "From mad cows to neurotic yeast: Novel molecular approaches to understand neurodegeneration". Microscopy and Microanalysis 14 SUPPL. 3 (2008): 105-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-53349095634&partnerID=MN8TOARS.
    10.1017/S143192760808954X
  519. Tetzlaff, J.E.; Putcha, P.; Outeiro, T.F.; Ivanov, A.; Berezovska, O.; Hyman, B.T.; McLean, P.J.. "CHIP targets toxic a-synuclein oligomers for degradation". Journal of Biological Chemistry 283 26 (2008): 17962-17968. http://www.scopus.com/inward/record.url?eid=2-s2.0-49649125680&partnerID=MN8TOARS.
    10.1074/jbc.M802283200
  520. Outeiro, T.F.; Marques, O.; Kazantsev, A.. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1782 6 (2008): 363-369. http://www.scopus.com/inward/record.url?eid=2-s2.0-43749121572&partnerID=MN8TOARS.
    10.1016/j.bbadis.2008.02.010
  521. Outeiro TF; Putcha P; Tetzlaff JE; Spoelgen R; Koker M; Carvalho F; Hyman BT; McLean PJ. "Correction: Formation of Toxic Oligomeric ?-Synuclein Species in Living Cells.". (2008): http://europepmc.org/abstract/PMC/PMC2556498.
  522. Mollenhauer, B.; Cullen, V.; Kahn, I.; Krastins, B.; Outeiro, T.F.; Pepivani, I.; Ng, J.; et al. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology 213 2 (2008): 315-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-49449105990&partnerID=MN8TOARS.
    10.1016/j.expneurol.2008.06.004
  523. Fleming, J.; Outeiro, T.F.; Slack, M.; Lindquist, S.L.; Bulawa, C.E.. "Detection of Compounds That Rescue Rab1-Synuclein Toxicity". Methods in Enzymology 439 (2008): 339-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549104669&partnerID=MN8TOARS.
    10.1016/S0076-6879(07)00425-9
  524. Outeiro TF; Kazantsev A. "Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies.". (2008): http://europepmc.org/abstract/med/19787096.
  525. Outeiro, T.F.; Kazantsev, A.. "Drug targeting of a-synuclein oligomerization in synucleinopathies". Perspectives in Medicinal Chemistry 2008 2 (2008): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953408910&partnerID=MN8TOARS.
  526. Outeiro, T.F.; Putcha, P.; Tetzlaff, J.E.; Spoelgen, R.; Koker, M.; Carvalho, F.; Hyman, B.T.; McLean, P.J.. "Formation of toxic oligomeric a-synuclein species in living cells". PLoS ONE 3 4 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-44849125207&partnerID=MN8TOARS.
    10.1371/journal.pone.0001867
  527. Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. "Yeast as a model for studying human neurodegenerative disorders". Biotechnology Journal 3 3 (2008): 325-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549104948&partnerID=MN8TOARS.
    10.1002/biot.200700217
  528. Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. "Erratum: Yeast as a model for studying human neurodegenerative disorders (Biotechnology Journal (2008) vol. 3 (325-338))". Biotechnology Journal 3 3 (2008): 421-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549148358&partnerID=MN8TOARS.
    10.1002/biot.421
  529. Kazantsev, A. G.; Outeiro, T. F.; Amore, A. M.; Pallos, J.; Kontopoulos, E.; Atmann, S.; Kufareva, I.; et al. "Development small molecule inhibitors of deacetylasee sirtuin 2 for treatment aggregate-associated neurodegenerative diseases". Journal of Neurochemistry (2008): https://publons.com/publon/9713450/.
  530. Outeiro, Tiago. "CHIP Targets Toxic a-Synuclein Oligomers for Degradation". Journal of Biological Chemistry (2008): https://publons.com/publon/9713443/.
    10.1074/JBC.M802283200
  531. Outeiro, Tiago. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology (2008): https://publons.com/publon/6146162/.
    10.1016/J.EXPNEUROL.2008.06.004
  532. Outeiro, Tiago Fleming; Putcha, Preeti; Tetzlaff, Julie E.; Spoelgen, Robert; Koker, Mirjam; Carvalho, Filipe; Hyman, Bradley T.; McLean, Pamela J.. "Formation of Toxic Oligomeric alpha-Synuclein Species in Living Cells". Plos One (2008): https://publons.com/publon/9713571/.
    10.1371/JOURNAL.PONE.0001867
  533. Outeiro, Tiago Fleming; Marques, Oldriska; Kazantsev, Aleksey. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2008): https://publons.com/publon/9713454/.
    10.1016/J.BBADIS.2008.02.010
  534. Tiago Outeiro. "Drug Targeting of a-Synuclein Oligomerization in Synucleinopathies". Perspectives in Medicinal Chemistry (2008): https://publons.com/publon/9713570/.
  535. St Martin, J.L.; Klucken, J.; Outeiro, T.F.; Nguyen, P.; Keller-McGandy, C.; Cantuti-Castelvetri, I.; Grammatopoulos, T.N.; et al. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry 100 6 (2007): 1449-1457. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847699408&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.04310.x
  536. Fleming Outeiro, T.; Tetzlaff, J.. "Mechanisms of Disease II: Cellular Protein Quality Control". Seminars in Pediatric Neurology 14 1 (2007): 15-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847188168&partnerID=MN8TOARS.
    10.1016/j.spen.2006.11.005
  537. Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. "Protein aggregation disorders". Neurobiology of Disease (2007): 111-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-47749092473&partnerID=MN8TOARS.
    10.1016/B978-012088592-3/50012-8
  538. Grammatopoulos, T.N.; Outeiro, T.F.; Hyman, B.T.; Standaert, D.G.. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications 363 3 (2007): 846-851. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848821185&partnerID=MN8TOARS.
    10.1016/j.bbrc.2007.09.043
  539. Outeiro, T.F.; Kontopoulos, E.; Altmann, S.M.; Kufareva, I.; Strathearn, K.E.; Amore, A.M.; Volk, C.B.; et al. "Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease". Science 317 5837 (2007): 516-519. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547599329&partnerID=MN8TOARS.
    10.1126/science.1143780
  540. Outeiro, T.F.; Grammatopoulos, T.N.; Altmann, S.; Amore, A.; Standaert, D.G.; Hyman, B.T.; Kazantsev, A.G.. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models". Biochemical and Biophysical Research Communications 357 3 (2007): 596-602. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247549725&partnerID=MN8TOARS.
    10.1016/j.bbrc.2007.03.163
  541. Outeiro, Tiago. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models". Biochemical and Biophysical Research Communications (2007): https://publons.com/publon/9713461/.
    10.1016/J.BBRC.2007.03.163
  542. Outeiro, Tiago. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry (2007): https://publons.com/publon/9713460/.
    10.1111/J.1471-4159.2006.04310.X
  543. Outeiro, Tiago. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications (2007): https://publons.com/publon/9713449/.
    10.1016/J.BBRC.2007.09.043
  544. Outeiro, Tiago Fleming; Kontopoulos, Eirene; Altmann, Stephen M.; Kufareva, Irina; Strathearn, Katherine E.; Amore, Allison M.; Volk, Catherine B.; et al. "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science (2007): https://publons.com/publon/9713462/.
    10.1126/SCIENCE.1143780
  545. Outeiro TF. "A bridge from Portugal to the States.". (2006): http://europepmc.org/abstract/med/17001768.
  546. Outeiro, T.F.. "A bridge from Portugal to the States.". Nature. 443 7107 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33749364368&partnerID=MN8TOARS.
  547. Bodner, R.A.; Outeiro, T.F.; Altmann, S.; Maxwell, M.M.; Cho, S.H.; Hyman, B.T.; McLean, P.J.; et al. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences of the United States of America 103 11 (2006): 4246-4251. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645235438&partnerID=MN8TOARS.
    10.1073/pnas.0511256103
  548. Outeiro, T.F.; Giorgini, F.. "Yeast as a drug discovery platform in Huntington's and Parkinson's diseases". Biotechnology Journal 1 3 (2006): 258-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749009306&partnerID=MN8TOARS.
    10.1002/biot.200500043
  549. Outeiro, T.F.; Klucken, J.; Strathearn, K.E.; Liu, F.; Nguyen, P.; Rochet, J.-C.; Hyman, B.T.; McLean, P.J.. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications 351 3 (2006): 631-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751216491&partnerID=MN8TOARS.
    10.1016/j.bbrc.2006.10.085
  550. Klucken, J.; Outeiro, T.F.; Nguyen, P.; McLean, P.J.; Hyman, B.T.. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". FASEB Journal 20 12 (2006): 2050-2057. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750117120&partnerID=MN8TOARS.
    10.1096/fj.05-5422com
  551. Bodner, RA; Outeiro, TF; Altmann, S; Maxwell, MM; Cho, SH; Hyman, BT; McLean, PJ; et al. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences (2006): https://publons.com/publon/9713442/.
    10.1073/PNAS.0511256103
  552. Outeiro, Tiago. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications (2006): https://publons.com/publon/9713459/.
    10.1016/J.BBRC.2006.10.085
  553. Outeiro, Tiago. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". The FASEB Journal (2006): https://publons.com/publon/9713457/.
    10.1096/FJ.05-5422COM
  554. Lindquist, S.; Fraenkel, E.; Outeiro, T.; Gitler, A.; Su, J.; Cashikar, A.; Jagadish, S.. "Yeast cells as a discovery platform for neurodegenerative disease". Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science) 3500 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-26444497156&partnerID=MN8TOARS.
  555. Outeiro, Tiago. "Yeast cells as a discovery platform for neurodegenerative disease". Research in Computational Molecular Biology, Proceedings (2005): https://publons.com/publon/9713456/.
    10.1007/11415770_8
  556. Rochet JC; Outeiro TF; Conway KA; Ding TT; Volles MJ; Lashuel HA; Bieganski RM; Lindquist SL; Lansbury PT. "Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.". (2004): http://europepmc.org/abstract/med/15126689.
    10.1385/JMN:23:1-2:023
  557. Outeiro TF; Muchowski PJ. "Molecular genetics approaches in yeast to study amyloid diseases.". (2004): http://europepmc.org/abstract/med/15126692.
    10.1385/JMN:23:1-2:049
  558. Derkatch, I.L.; Uptain, S.M.; Outeiro, T.F.; Krishnan, R.; Lindquist, S.L.; Liebman, S.W.. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences of the United States of America 101 35 (2004): 12934-12939. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444312783&partnerID=MN8TOARS.
    10.1073/pnas.0404968101
  559. Outeiro, T.F.; Muchowski, P.J.. "Molecular genetics approaches in yeast to study amyloid diseases". Journal of Molecular Neuroscience 23 1-2 (2004): 49-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669436&partnerID=MN8TOARS.
  560. Rochet, J.-C.; Outeiro, T.F.; Conway, K.A.; Ding, T.T.; Volles, M.J.; Lashuel, H.A.; Bieganski, R.M.; Lindquist, S.L.; Lansbury Jr., P.J.. "Interactions among a-synuclein, dopamine, and biomembranes: Some clues for understanding neurodegeneration in Parkinson's disease". Journal of Molecular Neuroscience 23 1-2 (2004): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344641972&partnerID=MN8TOARS.
  561. Da Cruz E Silva, E.F.; Outeiro, T.F.; Da Cruz E Silva, O.A.B.. "Symposium on novel therapeutic opportunities for neurodegenerative disease". Journal of Molecular Neuroscience 23 1-2 (2004): 1-2. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892653827&partnerID=MN8TOARS.
    10.1385/JMN:23:1-2:001
  562. Outeiro, Tiago. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences (2004): https://publons.com/publon/9713441/.
    10.1073/PNAS.0404968101
  563. Willingham, S.; Outeiro, T.F.; DeVit, M.J.; Lindquist, S.L.; Muchowski, P.J.. "Yeast Genes that Enhance the Toxicity of a Mutant Huntingtin Fragment or a-Synuclein". Science 302 5651 (2003): 1769-1772. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345189365&partnerID=MN8TOARS.
    10.1126/science.1090389
  564. Outeiro, T.F.; Lindquist, S.. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science 302 5651 (2003): 1772-1775. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345189364&partnerID=MN8TOARS.
    10.1126/science.1090439
  565. Resende, C.G.; Outeiro, T.F.; Sands, L.; Lindquist, S.; Tuite, M.F.. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology 49 4 (2003): 1005-1017. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041563922&partnerID=MN8TOARS.
    10.1046/j.1365-2958.2003.03608.x
  566. Resende, CG; Outeiro, TF; Sands, L; Lindquist, S; Tuite, MF. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology (2003): https://publons.com/publon/9713444/.
    10.1046/J.1365-2958.2003.03608.X
  567. Outeiro, Tiago. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science (2003): https://publons.com/publon/9713446/.
    10.1126/SCIENCE.1090439
  568. Outeiro, Tiago. "Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or -Synuclein". Science (2003): https://publons.com/publon/9713445/.
    10.1126/SCIENCE.1090389
Capítulo de livro
  1. Brás, I.C.; Popova, B.; Braus, G.H.; Outeiro, T.F.. "Yeast-based screens to target alpha-synuclein toxicity". 145-156. 2019.
    10.1007/978-1-4939-9124-2_12
  2. Brás, I.C.; Xylaki, M.; Outeiro, T.F.. "Mechanisms of alpha-synuclein toxicity: An update and outlook". 2019.
    10.1016/bs.pbr.2019.10.005
  3. Pavlou, M.A.S.; Outeiro, T.F.. "Epigenetics in parkinson’s disease". 363-390. 2017.
    10.1007/978-3-319-53889-1_19
  4. Peelaerts, W.; Outeiro, T.F.. "Synuclein misfolding as a therapeutic target". 21-47. 2017.
  5. Tenreiro, S.; Macedo, D.; Marijanovic, Z.; Outeiro, T.F.. "Analysis of protein oligomeric species by sucrose gradients". 331-339. 2016.
    10.1007/978-1-4939-3756-1_21
  6. Outeiro, T.F.. "Alpha-synuclein". 31-34. 2016.
  7. Herrera, F.; Gonçalves, S.; Branco dos Santos, J.; Fleming Outeiro, T.. "Studying the Molecular Determinants of Protein Oligomerization in Neurodegenerative Disorders by Bimolecular Fluorescence Complementation". 133-145. 2013.
  8. Gonçalves, S.; Miranda, H.V.; Outeiro, T.F.. "Novel Molecular Therapeutics in Parkinson's Disease". 245-265. 2012.
  9. Outeiro, T.F.; Lopes, L.V.. "Synaptic dysfunction in Parkinson's disease: From protein misfolding to functional alterations". 257-267. 2011.
  10. Marques, S.C.F.; Pereira, C.M.F.; Outeiro, T.F.. "Epigenetics and neurodegeneration: A connection overlooked". 241-252. 2011.
  11. Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. "Protein aggregation disorders". 111-123. 2007.
Documento de trabalho
  1. Da Silva, Inês S.; Cardoso, Ana R.; Reimer, Lasse; König, Annekatrin; van Riesen, Christoph; Outeiro, Tiago; Henning Jensen, Poul; M. Goreti. F. Sales. Autor correspondente: M. Goreti. F. Sales. 2022. "Molecularly imprinted polymer-based electrochemical biosensor for alpha-synuclein detection in Parkinson´s Disease (To be submitted to Biosensors and Bioelectronics)".
Edição de número de revista
  1. Belo Fernandes, Júlio; Godinho, Catarina; Baixinho, Cristina Lavareda; Outeiro, Tiago. "One Health Care in Psychiatric and Neurological Diseases". Frontiers in Psychiatry (2023):
  2. Fernandes, J. B. ; Godinho, Catarina; Baixinho, Cristina Lavareda; Outeiro, Tiago. "Personalized Care in Neurological Diseases". Frontiers in Human Neuroscience (2022):
Poster em conferência
  1. Amaral, Leslie; Rego, Antonio; Outeiro, Tiago; Côrte-Real, M; Chaves, SR. "A humanized yeast model system to assess the risk of environment contaminants to Parkinson's disease progression". Trabalho apresentado em The Biochemistry Global Summit, 2022.
  2. Lungu, Ruxanda; F. Fernandes, Francisca; Outeiro, Tiago; Shemesh, Noam. "Brain-wide olfactory aberrations in a Parkinson's Disease mouse model revealed by Functional MRI". Trabalho apresentado em ISMRM & SMRT Annual Meeting & Exhibition 15-20 May 2021, 2021.
  3. Andreia Silva; Joana Rodrigues; Outeiro, Tiago; Tenreiro, Sandra. Autor correspondente: Tenreiro, Sandra. "Dissecting the effect of aSyn familial mutations on aSyn fate and lysosomal dysfunction in a yeast model of Parkinson's disease". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, 2019.
  4. Pais, Teresa Faria; Guerreiro, Patrícia; Coelho, Joana; Lima, Inês; Macedo, Paula; Lopes, Luisa; Outeiro, Tiago. "Role of type I IL-1R in a transgenic mouse model of alpha-synucleinopathies". Trabalho apresentado em CSHL conference on Neurodegenerative Diseases: Biology & Therapeutics, 2014.
  5. Soares, Rui S.; Ana Correia; Outeiro, Tiago. "Zebrafish as a model for studying Parkinson¿s disease.". Trabalho apresentado em 17th Multidisciplinary International Conference of Neuroscience and Biological Psychiatry "Stress and Behavior", 2012.
  6. Pais, Teresa Faria; Machado Oliveira, Rita; Marijanovic, Zrinka; Patrícia S, Guerreiro; Oliveira, Ana Osório; Outeiro, Tiago. "Aging and Neurodegeneration: Common Targets, Common Hopes". Trabalho apresentado em World Parkinson Congress, 2009.
  7. Pais, Teresa Faria; Guerreiro, Patrícia; Marques, Oldriska; Outeiro, Tiago. "Sirtuins: a link between ageing and microglial cell neurotoxicity". Trabalho apresentado em Annual meeting of the Society for Neurosciences, 2009.
Pré-impressão
  1. Ricardo Sant’Anna; Bruno K Robbs; Júlia Araújo de Freitas; Patrícia Pires dos Santos; Annekatrin König; Tiago Fleming Outeiro; Debora Foguel. "Alpha-synuclein oligomers activate NFAT proteins modulating synaptic homeostasis and apoptosis". 2023. https://doi.org/10.1101/2023.02.21.529374.
    10.1101/2023.02.21.529374
  2. Anton Emil Dorn; Emile de Bruyn; Giulia Rossetti; Claudio Fernandez; Tiago F. Outeiro; Jörg B. Schulz; Paolo Carloni. "Impact of Phosphorylation on alpha-Synuclein Structural Determinants". 2023. https://doi.org/10.1101/2023.03.10.531864.
    10.1101/2023.03.10.531864
  3. Günter U. Höglinger; Charles H. Adler; Daniela Berg; Christine Klein; Tiago F. Outeiro; Werner Poewe; Ronald Postuma; Jon Stoessl; Anthony E. Lang. "Towards a Biological Definition of Parkinson’s Disease". 2023. https://doi.org/10.20944/preprints202304.0108.v1.
    10.20944/preprints202304.0108.v1
  4. Ruxanda Lungu; Francisca F. Fernandes; Tiago F. Outeiro; Noam Shemesh. "Brain-wide sensory aberrations in a Parkinson’s Disease mouse model revealed by functional MRI". 2022. https://doi.org/10.1101/2022.04.06.487227.
    10.1101/2022.04.06.487227
  5. Eftychia Vasili; Antonio Dominguez-Meijide; Manuel Flores-Léon; Mohammed Al-Azzani; Angeliki Kanellidi; Ronald Melki; Leonidas Stefanis; Tiago Outeiro. "Endogenous Levels of Alpha-synuclein Modulate Seeding and Aggregation in Cultured Cells". 2021. https://doi.org/10.21203/rs.3.rs-1152192/v1.
    10.21203/rs.3.rs-1152192/v1
  6. David J. Koss; Daniel Erskine; Andrew Porter; Pawel Palmoski; Marta Leite; Johannes Attems; Tiago F. Outeiro. "Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies". 2021. https://doi.org/10.1101/2021.10.20.465125.
    10.1101/2021.10.20.465125
Revisão de livro
  1. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". http://hdl.handle.net/10362/29887.
    https://doi.org/10.15698/mic2018.01.607
  2. Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". http://www.scopus.com/inward/record.url?scp=85047880162&partnerID=8YFLogxK.
    https://doi.org/10.3389/fneur.2018.00347
  3. Menezes, R.; Macedo, Diana Leonor Constantino; Santos, Maria Claudia; Tenreiro, Sandra; Outeiro, Tiago F; Instituto de Tecnologia Química e Biológica (ITQB); NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "From the baker to the bedside: yeast models of Parkinson's disease". http://microbialcell.com/wordpress/wp-content/uploads/2015/08/2015A-Menezes-Microbial-Cell.pdf.
    https://doi.org/10.15698/mic2015.08.219
  4. Lopes da Fonseca, Tomás; Villar-Pique, Anna; Outeiro, Tiago F; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "The interplay between alpha-Synuclein clearance and spreading". http://hdl.handle.net/10362/23233.
    https://doi.org/10.3390/biom5020435
  5. Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.. "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". http://www.scopus.com/inward/record.url?scp=85047880162&partnerID=8YFLogxK.
    https://doi.org/10.3389/fneur.2018.00347
  6. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". http://www.scopus.com/inward/record.url?scp=85047020782&partnerID=8YFLogxK.
    https://doi.org/10.15698/mic2018.01.607
Tese / Dissertação
  1. Dionísio, Pedro A.. "Tuning cell death and inflammation in parkinson's disease". Doutoramento, 2020. http://hdl.handle.net/10451/42843.
  2. Ferreira, Mariana Temido Mendes. "The role of A2A receptors in cognitive decline : decoding the molecular shift towards neurodegeneration". Doutoramento, 2018. http://hdl.handle.net/10451/37953.
  3. Vaz, Rita Leitão Landeiro, 1988-. "Screening and validation of molecules with therapeutic properties in in vivo models of parkinson’s disease". Doutoramento, 2018. http://hdl.handle.net/10451/37407.
  4. Branco-Santos, J. "The role of post-translational modifications on the oligomerization, aggregation and toxicity of mutant huntingtin". Doutoramento, 2018. http://hdl.handle.net/10451/38930.
  5. Oliveira, Ana Cristina Osório Marinho. ""Deciphering the role of aß-crystallin in huntington’s disease"". Doutoramento, 2017. http://hdl.handle.net/10451/28882.
  6. Gonçalves, Susana Alexandra de Barros, 1983-. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". Doutoramento, 2017. http://hdl.handle.net/10451/28406.
  7. Gonçalves, Susana Alexandra de Barros, 1983-. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". Doutoramento, 2017. http://hdl.handle.net/10451/28406.
  8. Silva, Ana Maria Ferreira da, 1983-. "Use of genomic dna-reporter tools to dissect pathological mechanisms caused by GAA expansions in Friedreich’s Ataxia". Doutoramento, 2016. http://hdl.handle.net/10451/25153.
  9. Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. "The interplay between alpha-synuclein and ATP13A2 : towards the understanding of the molecular basis of Parkinson’s disease". Doutoramento, 2016. http://hdl.handle.net/10451/28900.
  10. Brás, Inês Filipa Caldeira. "Molecular insights into the role of alfa-synuclein phosphorylation in synucleinopathies". Mestrado, 2016. http://hdl.handle.net/10451/27689.
  11. Dias, Ana Rita Abrantes. "The role of sirtuin 2 in oligodendroglia on dopaminergic neuron differentiation and regeneration". Mestrado, 2016. http://hdl.handle.net/10316/41275.
  12. Guerreiro, Patricia I. da Silva. "The role of LRRK2 in Parkinson’s disease : from function to dysfunction". Doutoramento, 2015. http://hdl.handle.net/10451/22717.
  13. Geraldes, Vera Lúcia Poço, 1983-. "Hypothalamic and medullar mechanisms for long-term autonomic regulation of arterial blood pressure". Doutoramento, 2014. http://hdl.handle.net/10451/15834.
  14. Fleming, Maria Leonor Lemos Pereira Miller, 1983-. "Deciphering the molecular role of DJ-1 in the etiology of Parkinson’s and Huntingtons’s disease". Doutoramento, 2014. http://hdl.handle.net/10451/15629.
  15. Basso, Elisa, 1983-. "The role of alpha-synuclein phosphorylation in synucleinopathies". Doutoramento, 2014. http://hdl.handle.net/10451/15477.
  16. Vittori, Angelica. "Copy number variation and Huntington’s disease". Doutoramento, 2014. http://hdl.handle.net/10451/15627.
  17. Silva, Filipa Magalhães, 1990-. "Alpha-synuclein phosphorylation role on Parkinson’s disease". Mestrado, 2013. http://hdl.handle.net/10451/10070.
  18. Amaral, Marta Isabel Magalhães Mota do, 1984-. "Structure and mechanism of kynurenine 3-monooxygenase, a candidate huntington’s disease drug target". Doutoramento, 2013. http://hdl.handle.net/10451/9898.
  19. Oliveira, Márcia Santos. "Modulation of a-synuclein aggregation and toxicity". Mestrado, 2013. http://hdl.handle.net/10362/11195.
  20. Martinho, Renato Gomes da Silva, 1990-. "SIRT2: in the crossroad of aging, neurodegeneration and autophagy". Mestrado, 2013. http://hdl.handle.net/10451/9610.
  21. Rodrigues, Eva Sofia Ferreira. "Comparative study of the effect of selected mutations on alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation (BiFC) assay". Mestrado, 2012. http://hdl.handle.net/10316/25140.
  22. Lázaro, Diana Fernandes. "Systematic comparison of the effects of a-synuclein mutations on aggregation in Parkinson’s Diseases". Mestrado, 2012. http://hdl.handle.net/10451/7246.
  23. Santos, Joana Margarida Marques Branco dos, 1987-. "The role of N-terminal phosphorylation on Huntingtin oligomerization, aggregation and toxicity". Mestrado, 2012. http://hdl.handle.net/10451/7554.
  24. Marques, Sueli Cristina Ferreira. "Chromatin remodeling in Alzheimer's disease pathogenesis". Doutoramento, 2011. http://hdl.handle.net/10316/20157.
  25. Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. "Zebrafish : a new model of Parkinson's disease". Mestrado, 2010. http://hdl.handle.net/10451/2214.
  26. Almeida, Bruno. "Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death". Doutoramento, 2009. http://hdl.handle.net/1822/9511.
  27. Marques, Oldriska. "SIRT2 as a putative target in parkinson's disease therapy". Mestrado, 2008. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000583288.
  28. Outeiro, Tiago Fleming de Oliveira. "Yeast as a model organism to study diseases of protein misfolding". Doutoramento, 2004. http://hdl.handle.net/10216/10638.

Propriedade Intelectual

Patente
  1. Neves, Vera; Côrte-Real, Sofia; Neves, Vera; Oliveira, Soraia; Canhão, P; Outeiro, Tiago; Castanho, Miguel; Aires-da-Silva, Frederico. 2016. "Antibody molecules and peptide delivery systems for use in Alzheimer¿s disease and related disorders". Estados Unidos.
    Permitida

Outros

Outra produção
  1. Alpha-synuclein levels modulate seeding and aggregation in cultured cells. 2021. Eftychia Vasili; Antonio Dominguez-Meijide; Manuel Flores-León; Mohammed Al-Azzani; Angeliki Kanellidi; Ronald Melki; Leonidas Stefanis; Tiago Fleming Outeiro. https://doi.org/10.21203/rs.3.rs-666210/v1.
    10.21203/rs.3.rs-666210/v1
  2. Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells. 2021. Inês Caldeira Brás; Mohammad Hossein Khani; Dietmar Riedel; Iwan Parfentev; Ellen Gerhardt; Christoph van Riesen; Henning Urlaub; Tim Gollisch; Tiago Fleming Outeiro. https://doi.org/10.1101/2021.06.24.449731.
    10.1101/2021.06.24.449731
  3. Cofilin pathology is a new player on a-synuclein-induced spine impairment in models of hippocampal synucleinopathy. 2021. MI Oliveira da Silva; M Santejo; IW Babcock; A Magalhães; LS Minamide; E Castillo; E Gerhardt; et al. https://doi.org/10.1101/2021.02.02.425931.
    10.1101/2021.02.02.425931
  4. Hsp27 reduces glycation-induced toxicity and aggregation of a-synuclein. 2020. Hugo Vicente Miranda; Ana Chegão; Márcia Oliveira; Bárbara Fernandes Gomes; Francisco J. Enguita; Tiago Fleming Outeiro. https://doi.org/10.1101/2020.03.03.975037.
    10.1101/2020.03.03.975037
  5. Effects of pharmacological modulators of a-synuclein and tau aggregation and internalization. 2020. Antonio Dominguez-Meijide; Eftychia Vasili; Annekatrin König; Maria-Sol Cima-Omori; Andrei Leonov; Sergey Ryazanov; Markus Zweckstetter; Christian Griesinger; Tiago F. Outeiro. https://doi.org/10.1101/2020.01.27.921643.
    10.1101/2020.01.27.921643
  6. Guidelines and recommendations on yeast cell death nomenclature. Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi-ni. 2018. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. http://hdl.handle.net/1822/57984.
    10.15698/mic2018.01.607
  7. (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis. Parkinson's disease (PD) is an age-related neurodegenerative disease associated with the misfolding and aggregation of alpha-synuclein (aSyn). The molecular underpinnings of PD are still obscure, but nutrition may play an important role in the prevention, onset, and disease progression. Dietary (poly)phenols revert and prevent age-related cognitive decline and neurodegeneration in model systems. H. 2018. Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. http://www.scopus.com/inward/record.url?scp=85046675039&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-018-25118-z
  8. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. 2017. Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M.A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. http://hdl.handle.net/10400.18/5439.
    Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.
  9. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin. 2017. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. http://hdl.handle.net/10400.18/5465.
    PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar.
  10. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson’s disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. 2017. Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. http://hdl.handle.net/10400.26/19438.
    Hugo Vicente Miranda, Éva M. Szego, Luís M. A. Oliveira, Carlo Breda, Ekrem Darendelioglu, Rita M. de Oliveira, Diana G. Ferreira, Marcos A. Gomes, Ruth Rott, Márcia Oliveira, Francesca Munari, Francisco J. Enguita, Tânia Simões, Eva F. Rodrigues, Michael
  11. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. 2017. Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. http://hdl.handle.net/10451/32818.
    10.1093/brain/awx056
  12. Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease. Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practic. 2017. Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. http://www.scopus.com/inward/record.url?scp=85032025050&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-017-14175-5
  13. The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. a-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the accumulation of aSyn in Lewy Bodies and Lewy neurites in disorders such as PD, dementia with Lewy bo. 2016. Lázaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina S; Tenreiro, Sandra; Ventura, Salvador; et al. http://hdl.handle.net/10362/25033.
    https://doi.org/10.1186/s40478-016-0402-8
  14. Glycation potentiates neurodegeneration in models of Huntington's disease. Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. By modifying aminogroups, glycation interferes with folding of proteins, increasing their aggregation potential. Here, we studied the effect of pharmacological and genetic manipulation of glycation on huntingtin (HTT), the causati. 2016. Miranda, Hugo Vicente; Gomes, Marcos Antonio; Branco-Santos, Joana; Breda, Carlo; Lazaro, Diana F; Lopes, Lusa Vaqueiro; Herrera, Federico; et al. http://hdl.handle.net/10362/22380.
    https://doi.org/10.1038/srep36798
  15. Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles. The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether gene expression differences in peripheral blood may be used as a signature of Parkinson's disease (PD) progression, thereby shedding light into p. 2016. Pinho, Raquel; Guedes, Leonor C; Soreq, Lilach; Lobo, Patricia P; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M; et al. http://hdl.handle.net/10362/26640.
    https://doi.org/10.1371/journal.pone.0157852
  16. A disfunção cognitiva nas doenças neurodegenerativas. As doenças neurodegenerativas são neuropatias que incluem as doenças de Parkinson (DP), de Alzheimer (DA) e de Hungtington, assim como a esclerose lateral amiotrófica e demências fronto-temporais. Podendo variar na sua patofisiologia, estas doenças estão associadas ao envelhecimento geral da população, e à presença comum de formas proteicas misfolded e agregadas no cérebro dos indivíduos afectados. 2016. Gonçalves, Susana; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6007.
  17. A levedura como modelo para estudar as bases moleculares da doença de Parkinson. A doença de Parkinson (DP) é uma doença neurodegenerativa sem cura, está associada ao envelhecimento e caracteriza-se pela acumulação de inclusões proteicas intraneuronais conhecidas como corpos de Lewy (CL) no cérebro. Os CL são inclusões maioritariamente compostas pela proteína alfa-sinucleína (aSyn), pensando-se estarem associados à neurodegeneração característica na DP. A aSyn está sujeita a v. 2016. Tenreiro, Sandra; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6006.
  18. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms of aSyn may explain the typical patterns of disease progression. However, the molecular mechanisms contro. 2016. Gonçalves, Susana A; Macedo, Diana; Raquel, Helena; Simões, Pedro D; Giorgini, Flaviano; Ramalho, José S; Barral, Duarte C; Ferreira Moita, Luís; Outeiro, Tiago Fleming. http://hdl.handle.net/10400.7/591.
    Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, et al. (2016) shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. PLoS Genet 12(4):
  19. A disfunção cognitiva nas doenças neurodegenerativas. As doenças neurodegenerativas são neuropatias que incluem as doenças de Parkinson (DP), de Alzheimer (DA) e de Hungtington, assim como a esclerose lateral amiotrófica e demências fronto-temporais. Podendo variar na sua patofisiologia, estas doenças estão associadas ao envelhecimento geral da população, e à presença comum de formas proteicas misfolded e agregadas no cérebro dos indivíduos afectados. 2016. Gonçalves, Susana; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6007.
  20. A levedura como modelo para estudar as bases moleculares da doença de Parkinson. A doença de Parkinson (DP) é uma doença neurodegenerativa sem cura, está associada ao envelhecimento e caracteriza-se pela acumulação de inclusões proteicas intraneuronais conhecidas como corpos de Lewy (CL) no cérebro. Os CL são inclusões maioritariamente compostas pela proteína alfa-sinucleína (aSyn), pensando-se estarem associados à neurodegeneração característica na DP. A aSyn está sujeita a v. 2016. Tenreiro, Sandra; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6006.
  21. The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticos. 2016. Batalha, Vania L; Ferreira, Diana G; Coelho, Joana E.; Valadas, Jorge S; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; et al. http://hdl.handle.net/10362/22379.
    https://doi.org/10.1038/srep31493
  22. Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications. a-synuclein (a-syn) is the major component of Lewy bodies, a pathological hallmark of Parkinson's disease and other synucleinopathies. The characterization of a-syn post-translational modifications (PTMs), thought to interfere with its aggregation propensity and cellular signaling, has been limited by the availability of extraction methods of endogenous protein from cells and tissues, and by the a. 2013. Vicente Miranda, Hugo; Xiang, Wei; Oliveira, Rita M. de; Simões, Tânia; Pimentel, José; Klucken, Jochen; Penque, Deborah; Outeiro, Tiago. http://hdl.handle.net/10400.18/1729.
    doi: 10.1111/jnc.12251
  23. SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. SNCA (a-synuclein) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that SNCA has an impact on cell clearance routes and protein quality control systems such as the ubiquitin-proteasome system (UPS) and autophagy. Recent advances in the key role of the autosomal recessive PARK2/PARKIN and PINK1 genes in mitophagy. 2012. Marques, Belém Sampaio; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Márcio; Tenreiro, Sandra; Franssens, Vanessa; Reichert, Andreas S.; et al. http://hdl.handle.net/1822/21186.
    10.4161/auto.21275
  24. Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation. Parkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of t. 2012. Diógenes, Maria José; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente; Maiolino, Francesca; Guerreiro, Patrícia; Näsström, Thomas; et al. http://hdl.handle.net/10400.26/4825.
    The Journal of Neuroscience, 22 August 2012, 32(34): 11750-11762; doi: 10.1523/¿JNEUROSCI.0234-12.2012
  25. Galiza, esse lugar da Europa. Paper presented on the 6th International Anthropology Students Conference held at University Fernando Pessoa in 1998. Ponencia presentada en el 6º Congreso Internacional de Estudiantes de Antropología realizado en la Universidad Fernando Pessoa en 1998. Document présenté lors de le 6ème  Congrès International des Étudiants d'Anthropologie réalisé à l'Université Fernando Pessoa en 1998. Comunicação. 2012. Igrejas Peres, Aitor Tiago; Tobio Espinho, Paulo; Fernandes Outeiro, Paula; Malvar Fernandes, Paulo. https://revistas.rcaap.pt/antropologicas/article/view/1052.
  26. Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. Background: Parkinson’s disease is characterized by the presence of cytoplasmic inclusions, known as Lewy bodies, containing both aggregated a-synuclein and its interaction partner, synphilin-1. While synphilin-1 is known to accelerate inclusion formation by a-synuclein in mammalian cells, its effect on cytotoxicity remains elusive. Methodology/Principal Findings: We expressed wild-type synphilin-. 2010. Büttne, Sabrina; Delay, Charlotte; Franssens, Vanessa; Bammens, Tine; Ruli, Doris; Zaunschirm, Sandra; Oliveira, Rita Machado de; et al. http://hdl.handle.net/10451/6206.
    doi:10.1371/journal.pone.0013700
  27. Zooming into protein oligomerization in neurodegeneration using BiFC. Several neurodegenerative diseases are characterized by the accumulation of misfolded and aggregated proteins, which lead to neurotoxicity. However, the nature of those toxic species is controversial. Developments in optical microscopy and live-cell imaging are essential in providing crucial insight into the molecular mechanisms involved. In particular, the technique of bimolecular fluorescence co. 2010. Gonçalves, Susana A.; Matos, Joana E.; Outeiro, Tiago F.. http://dx.doi.org/10.1016/j.tibs.2010.05.007.
    http://dx.doi.org/10.1016/j.tibs.2010.05.007
  28. A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS. Purpose: To identify, characterize and perform a relative quantification of human transthyretin (TTR) variants in human saliva. Experimental design: Serum and saliva samples were collected from healthy and familial amyloidotic polyneuropathy (FAP) patients, proteins separated by SDS-PAGE, TTR bands excised, in-gel digested and analyzed by MALDI-FTICR. Results: We identified and performed a relativ. 2010. Costa, Gonçalo da; Guerreiro, Ana; Correia, Catarina F.; Gomes, Ricardo J.; Freire, António; Monteiro, Estela; Barroso, Eduardo; et al. http://hdl.handle.net/10451/6376.
    DOI 10.1002/prca.200900118
  29. A biomedicina na prevenção, diagnóstico e terapia de doenças. A biomedicina assume um papel cada vez mais importante na prevenção, diagnóstico e terapia de inúmeras doenças que afectam a população mundial, contribuindo para uma significativa melhoria das condições de vida e um consequente aumento da longevidade. A caracterização molecular das populações no contexto do seu estado de saúde, e as novas disciplinas que surgem dos avanços tecnológicos, permitem-n. 2009. Outeiro, Tiago. http://hdl.handle.net/10400.14/9872.
  30. Biomedicina na prevenção, diagnóstico e terapia de doenças. Desde que o Homem povoou a Terra que procura compreender a origem da sua existência. No ano 2000, assinalou-se um marco notável na história da Biologia, mas também da Humanidade: foi apresentada a primeira versão do código da vida humana – a sequência de DNA que constitui o genoma humano. As cerca de 3x109 (3 mil milhões) de bases de DNA que constituem o genoma humano formam os cerca de 25 mil gen. 2009. Outeiro, Tiago Fleming. http://hdl.handle.net/11144/1118.
Atividades

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/03/01 - Atual Bases Moleculares de Neurodegeneração Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
Distinções

Outra distinção

2015 Medalha de Ouro
2013 Medalha de Mérito - Prata
Ministério da Saúde, Moçambique
2009 EMBO Installation Grant
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Alemanha
2009 Young Investigator Award
2008 Pfizer Prize for Research in Aging
2007 Research in the life sciences
Fundação Calouste Gulbenkian, Portugal
2003 Young Investigator Award
2001 Young Investigator Award
1998 Top Student in the 1998 Biochemistry Class
Fundação Engenheiro António de Almeida, Portugal
1998 Top Student in the 1998 Biochemistry Class
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal