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Tiago Outeiro. Concluiu o(a) Mestrado integrado em Bioquímica em 1998 pelo(a) Universidade do Porto Faculdade de Ciências, Mestrado integrado em Bioquímica em 1998 pelo(a) Universidade do Porto Faculdade de Ciências, Doutoramento em Ciências Biomédicas em 2004 pelo(a) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar e Doutoramento em Ciências Biomédicas em 2004 pelo(a) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar. É Professor Catedrático no(a) Georg-August-Universität Göttingen, Full Professor, Director of the Department of Experimental Neurodegeneration no(a) Georg-August-Universität Göttingen e Professor Catedrático no(a) Into Newcastle University. Publicou 568 artigos em revistas especializadas. Possui 11 capítulo(s) de livros. Possui 1 patente(s) registada(s). Recebeu 10 prémio(s) e/ou homenagens. Nas suas atividades profissionais interagiu com 10147 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Teses de doutoramento - 2014; Sistema nervoso simpático; Hipertensão; Núcleo hipotalâmico paraventricular; Órgãos-alvo; Barorreflexo; Doença de Parkinson; Saccharomyces cerevisiae; Fosforilação; Agregação celular; Teses de mestrado - 2013; lpha-synuclein; Autophagy; Mitophagy; Sirtuins; Chronological aging; Yeast; Synucleinopathies; alpha-synuclein; Science & Technology; Journal Article; Cromatina; Doença de Alzheimer; Aging; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Models, Animal; Drosophila; Enzyme Inhibitors; Female; Glycosylation; Hippocampus; Humans; Induced Pluripotent Stem Cells; Male; Mice; Mice, Transgenic; Neurodegenerative Diseases; Protein Aggregation, Pathological; Protein Processing, Post-Translational; Pyruvaldehyde; Rats; Yeasts; alpha-Synuclein; Genómica Funcional e Estrutural; Neurociências; Peixe-zebra; Trifosfato de adenosina; Modelos genéticos; Biologia computacional; Teses de mestrado - 2010; accidental cell death; apoptosis; autophagic cell death; autophagy; caspases; mitochondrial membrane permeabilization; mitotic catastrophe; model organism; necrosis; reactive oxygen species; regulated cell death; Post-translational Modi¿cations; Parkinson's Disease; Proteomics; a-synuclein; Quinurenina 3-mono-oxigenase; Doença de Huntington; Doenças neurodegenerativas; Terapêutica; Teses de doutoramento - 2013; Alpha-synuclein; a-syn oligomers; Parkinson's disease; Cell aggregation; Cell death; Sir2; Parkinson disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylation; Cell Membrane; Cerebral Cortex; Dopaminergic Neurons; Gene Deletion; Gene Knockdown Techniques; HEK293 Cells; Lysine; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neuroprotection; Parkinson Disease; Protein Aggregates; Protein Binding; Sirtuin 2; Biomedicina; Prevenção; Fisiologia; Investigação de translação; Glycation; Parkinson¿s disease; Neurodegeneration; Leveduras; Deficiências na proteostase; Hsp27; Hsp70; Methylglyoxal; Familial amyloidotic polyneuropathy; FTICR; Saliva; Systemic amyloidosis; Transthyretin; General; Alfa-sinucleína; Autofagia; Teses de mestrado- 2013; Complementação de fluorescência bimolecular; Oligomerização; Mutações; Teses de doutoramento - 2016; Ataxia de Friedreich; Heterocromatina; Transcrição genética; Expansão das repetições de trinucleotídeos; Domínio/Área Científica::Ciências Médicas::Medicina Básica; Biologia celular; RNA interferência; Teses de mestrado; Variações do número de cópias de DNA; Genes modificadores; Biologia humana; Fósforilação; Teses de mestrado - 2012; Secretion; Hyperexpression techniques; Oligomers; Toxicity; Cytotoxicity; Immunoblotting; Immunocytochemistry; Fluorescence microscopy; Corpos de Lewy; Drug discovery; Hyperkinesia; Hypokinesia; Movement disorders; Zebrafish models; Neurology; Clinical Neurology; Teses de doutoramento - 2015; Proteínas tau; LRRK2; Teses de doutor
Identification

Personal identification

Full name
Tiago Outeiro

Citation names

  • Outeiro, Tiago

Author identifiers

Ciência ID
BC14-20AB-8D68
ORCID iD
0000-0003-1679-1727

Addresses

  • Waldweg 33, Department of Experimental Neurodegeneration, 37073, Goettingen, N/A, Germany (Professional)

Websites

  • http://www.neurodegeneration.uni-goettingen.de/ (Scholar)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2004
Concluded
Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Yeast as a model to investigate the molecular basis of neurodegeneration" (THESIS/DISSERTATION)
Aprovado por unanimidade
2004
Concluded
Ciências Biomédicas (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Yeast as a Model Organism to Study Diseases of Protein Misfolding" (THESIS/DISSERTATION)
1998
Concluded
Bioquímica (Mestrado integrado)
Universidade do Porto Faculdade de Ciências, Portugal
16.3 valores
1998
Concluded
Formação de Formadores (Curso de Especialização Tecnológica)
Instituto do Emprego e Formação Profissional, Portugal
Concluido
1998
Concluded
Bioquímica (Mestrado integrado)
Universidade do Porto Faculdade de Ciências, Portugal
16.3 valores
Affiliation

Science

Category
Host institution
Employer
2015/01/01 - 2019/12/31 Principal Investigator (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2007 - 2013 Coordinating Researcher (Research) Instituto de Medicina Molecular, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2022/10/01 - Current Invited Full Professor (University Teacher) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/09/01 - Current Invited Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2017/11/01 - Current Full Professor (University Teacher) Into Newcastle University, United Kingdom
2011/01/01 - Current Full Professor (University Teacher) Georg-August-Universität Göttingen, Germany
2015 - 2018 Full Professor (University Teacher) iNOVA4Health, Portugal
2013/01/01 - 2016 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2016 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal

Others

Category
Host institution
Employer
2011/01/01 - Current Full Professor, Director of the Department of Experimental Neurodegeneration Georg-August-Universität Göttingen, Germany
2011/01/01 - 2014/12/31 Principal Investigator of the Neurodegeneration Unit at IMM (associate Unit due to my postition as Full Professor at the University Medical Center Goettingen, Germany Instituto de Medicina Molecular, Portugal
2004/10/01 - 2007/06/01 Postdoctoral Research Fellow Massachusetts General Hospital, United States
2001/09/01 - 2004/11/04 PhD Student Whitehead Institute for Biomedical Research, United States
1999/04/01 - 2001/09/01 PhD Student University of Chicago, United States
1998/02/01 - 1998/09/03 Research training/internship University of Leeds, United Kingdom
Projects

Grant

Designation Funders
2019/10 - Current The role of lead exposure in the nervous system and Parkinson¿s disease onset and progression
SFRH/BD/143286/2019
Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal

Universitätsmedizin Göttingen Experimental Neurodegeneration, Germany

Lancaster University Department of Biological Sciences, United Kingdom
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/10/31 iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)
UID/Multi/04462/2019
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade Nova de Lisboa Medical School, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/09 - 2014/06 PARK- Identification of molecules to treat Parkinson´s Disease using a novel zebrafish model
Ref. 5553/4/Ae (acronym: PARK)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia

Eurostars
Concluded

Contract

Designation Funders
2023/03/01 - 2024/08/31 Estudo do BUB1 em neurodesenvolvimento: identificação de novas funções Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Estudo do BUB1 em neurodesenvolvimento: identificação de novas funções Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2022/02/28 Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2022/02/28 Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2021/12/31 Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas
PTDC/MED-FAR/31323/2017
Instituto de Biologia Molecular e Celular, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/06/01 - 2020/02/29 Defesas anti-glicação como alvo terapêutico para a doença de Parkinson
PTDC/NEU-OSD/5644/2014
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

iNOVA4Health, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2020/02/29 Defesas anti-glicação como alvo terapêutico para a doença de Parkinson
PTDC/NEU-OSD/5644/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

iNOVA4Health, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2020/02/29 Defesas anti-glicação como alvo terapêutico para a doença de Parkinson
PTDC/NEU-OSD/5644/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

iNOVA4Health, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2020/02/29 Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central
PTDC/BBB-NAN/1578/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2020/02/29 Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central
PTDC/BBB-NAN/1578/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2020/02/29 Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central
PTDC/BBB-NAN/1578/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/10/31 Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer
PTDC/QEQ-MED/5512/2014
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/10/31 Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer
PTDC/QEQ-MED/5512/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/10/31 Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer
PTDC/QEQ-MED/5512/2014
Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/03/01 - 2017/10/31 Avaliação Abrangente e Não Enviesada de Fatores de Risco Genéticos e Ambientais para a Doença de Parkinson
JPND-RF/0001/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/10/31 Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador
PTDC/DTP-PIC/0904/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/10/31 Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador
PTDC/DTP-PIC/0904/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/10/31 Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador
PTDC/DTP-PIC/0904/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2014/05/31 Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson
EXPL/NEU-OSD/0606/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2014/05/31 Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson
EXPL/NEU-OSD/0606/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2014/05/31 Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson
EXPL/NEU-OSD/0606/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/05 - 2013/08/04 Análise das alterações da transcrição em modelos cerebrais e periféricos da doença de Huntington - influência da modulação das desacetilases das histonas
PTDC/SAU-FCF/108056/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/05 - 2013/07/31 Análise dos mecanismos moleculares que determinam disfunção da alfa-sinucleína e a citoxicidade na doença de Parkinson - o papel do GDNF
PTDC/SAU-NEU/101928/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína
PTDC/SAU-NEU/105215/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína
PTDC/SAU-NEU/105215/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 Modificação genética das células do núcleo paraventricular do hipotálamo (PVN) e medula rostroventrolateral (RVLM) para controlar cronicamente a hipertensão.
PTDC/SAU-OSM/109081/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína
PTDC/SAU-NEU/105215/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 Modificação genética das células do núcleo paraventricular do hipotálamo (PVN) e medula rostroventrolateral (RVLM) para controlar cronicamente a hipertensão.
PTDC/SAU-OSM/109081/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide
PTDC/QUI-QUI/102049/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R
PTDC/SAU-GMG/099655/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide
PTDC/QUI-QUI/102049/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R
PTDC/SAU-GMG/099655/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide
PTDC/QUI-QUI/102049/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R
PTDC/SAU-GMG/099655/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/05 - 2013/05/31 Alteração do tráfego intracelular mediado pela mitocôndria na doença de Parkinson
PTDC/SAU-NEU/102710/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/02/17 Strategic Project - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2012/12/31 Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória
PTDC/SAU-NEU/099853/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2012/12/31 Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória
PTDC/SAU-NEU/099853/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2012/12/31 Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória
PTDC/SAU-NEU/099853/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/12/31 Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores
PIC/IC/82760/2007
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/12/31 Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores
PIC/IC/82760/2007
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/12/31 Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores
PIC/IC/82760/2007
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/02 - 2011/12/31 A glicação de proteínas e amiloidogenese da transtiretina em levedura: Um sistema modelo de doenças neurodegenerativas amiloidóticas
PTDC/QUI/70610/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/02 - 2011/12/31 A glicação de proteínas e amiloidogenese da transtiretina em levedura: Um sistema modelo de doenças neurodegenerativas amiloidóticas
PTDC/QUI/70610/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/06/30 Efeito da glicação em proteínas chave da doença de Parkinson: estudos in vivo e in vitro dos mecanismos de folding, agregação e degradação da alfa-sinucleina, da sinfilina e da parkina em condições glicantes.
PTDC/QUI/73430/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/06/30 Efeito da glicação em proteínas chave da doença de Parkinson: estudos in vivo e in vitro dos mecanismos de folding, agregação e degradação da alfa-sinucleina, da sinfilina e da parkina em condições glicantes.
PTDC/QUI/73430/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1999/01/01 - 2002/12/31 AMYLOID FORMATION IN YEAST: COMPARATIVE STUDIES ON THE INFLUENCE OF CHAPERONES ON THE AGGREGATION PROCESS OF TRANSTHYRETIN AND OTHER AMYLOIDOGENIC PROTEINS
PRAXIS XXI/BD/18489/98
Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Brás, I.C.; Popova, B.; Braus, G.H.; Outeiro, T.F.. "Yeast-based screens to target alpha-synuclein toxicity". 145-156. 2019.
    10.1007/978-1-4939-9124-2_12
  2. Brás, I.C.; Xylaki, M.; Outeiro, T.F.. "Mechanisms of alpha-synuclein toxicity: An update and outlook". 2019.
    10.1016/bs.pbr.2019.10.005
  3. Pavlou, M.A.S.; Outeiro, T.F.. "Epigenetics in parkinson’s disease". 363-390. 2017.
    10.1007/978-3-319-53889-1_19
  4. Peelaerts, W.; Outeiro, T.F.. "Synuclein misfolding as a therapeutic target". 21-47. 2017.
  5. Tenreiro, S.; Macedo, D.; Marijanovic, Z.; Outeiro, T.F.. "Analysis of protein oligomeric species by sucrose gradients". 331-339. 2016.
    10.1007/978-1-4939-3756-1_21
  6. Outeiro, T.F.. "Alpha-synuclein". 31-34. 2016.
  7. Herrera, F.; Gonçalves, S.; Branco dos Santos, J.; Fleming Outeiro, T.. "Studying the Molecular Determinants of Protein Oligomerization in Neurodegenerative Disorders by Bimolecular Fluorescence Complementation". 133-145. 2013.
  8. Gonçalves, S.; Miranda, H.V.; Outeiro, T.F.. "Novel Molecular Therapeutics in Parkinson's Disease". 245-265. 2012.
  9. Outeiro, T.F.; Lopes, L.V.. "Synaptic dysfunction in Parkinson's disease: From protein misfolding to functional alterations". 257-267. 2011.
  10. Marques, S.C.F.; Pereira, C.M.F.; Outeiro, T.F.. "Epigenetics and neurodegeneration: A connection overlooked". 241-252. 2011.
  11. Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. "Protein aggregation disorders". 111-123. 2007.
Book review
  1. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". http://hdl.handle.net/10362/29887.
    https://doi.org/10.15698/mic2018.01.607
  2. Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". http://www.scopus.com/inward/record.url?scp=85047880162&partnerID=8YFLogxK.
    https://doi.org/10.3389/fneur.2018.00347
  3. Menezes, R.; Macedo, Diana Leonor Constantino; Santos, Maria Claudia; Tenreiro, Sandra; Outeiro, Tiago F; Instituto de Tecnologia Química e Biológica (ITQB); NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "From the baker to the bedside: yeast models of Parkinson's disease". http://microbialcell.com/wordpress/wp-content/uploads/2015/08/2015A-Menezes-Microbial-Cell.pdf.
    https://doi.org/10.15698/mic2015.08.219
  4. Lopes da Fonseca, Tomás; Villar-Pique, Anna; Outeiro, Tiago F; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "The interplay between alpha-Synuclein clearance and spreading". http://hdl.handle.net/10362/23233.
    https://doi.org/10.3390/biom5020435
  5. Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.. "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". http://www.scopus.com/inward/record.url?scp=85047880162&partnerID=8YFLogxK.
    https://doi.org/10.3389/fneur.2018.00347
  6. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". http://www.scopus.com/inward/record.url?scp=85047020782&partnerID=8YFLogxK.
    https://doi.org/10.15698/mic2018.01.607
Conference paper
  1. Grunho, Miguel; Godinho, Catarina; de Matos, António; Barroso, Helena; Carregosa, Ricardo; Marx, Frederico; Tomé, Morgane; et al. "Gut Status in Parkinson¿s Disease: The GutSPark Protocol". Paper presented in 5th International Congress of CiiEM, Almada, 2021.
    Published • 10.3390/msf2021005031
  2. Grunho, Miguel; Godinho, Catarina; Patita, Marta; Mocanu, Irina; Vieira, Ana; de Matos, António; Carregosa, Ricardo; et al. "Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson¿s Disease: The InflamaSPark Protocol". Paper presented in 5th International Congress of CiiEM, Almada, 2021.
    Published • 10.3390/msf2021005028
  3. Fernandes, J.T.S.; Tenreiro, S.; Pedrosa, C.R.; Gameiro, A.; Chu, V.; Outeiro, T.F.; Conde, J.P.. "Integration of single cell traps, chemical gradient generator and photosensors in a microfluidic platform for the study of alphasynuclein toxicity in yeast". 2014.
    10.1016/j.proeng.2014.11.273
Conference poster
  1. Lungu, Ruxanda; F. Fernandes, Francisca; Pires Monteiro, Sara; Outeiro, Tiago; Shemesh, Noam. "Unveiling Visual Impairments in a Progressive Parkinson's Disease Mouse Model: Insights from Functional MRI, validated via C-FOS and CBF". Paper presented in European Society for Molecular Imaging, 2024.
  2. Amaral, Leslie; Martins Márcia; Mendes, Filipa; Corte-Real M; Rego, António; Outeiro, Tiago; CHAVES, SUSANA. "A versatile yeast model to screen for pesticides as risk factors for synucleinopathies". Paper presented in I CBMA Open Day & II PhD|Bio Symposium, 2024.
  3. Amaral, Leslie; Rego, Antonio; Outeiro, Tiago; Côrte-Real, M; Chaves, SR. "A humanized yeast model system to assess the risk of environment contaminants to Parkinson's disease progression". Paper presented in The Biochemistry Global Summit, 2022.
  4. Lungu, Ruxanda; F. Fernandes, Francisca; Outeiro, Tiago; Shemesh, Noam. "Brain-wide olfactory aberrations in a Parkinson's Disease mouse model revealed by Functional MRI". Paper presented in ISMRM & SMRT Annual Meeting & Exhibition 15-20 May 2021, 2021.
  5. Andreia Silva; Joana Rodrigues; Outeiro, Tiago; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Dissecting the effect of aSyn familial mutations on aSyn fate and lysosomal dysfunction in a yeast model of Parkinson's disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, 2019.
  6. Pais, Teresa Faria; Guerreiro, Patrícia; Coelho, Joana; Lima, Inês; Macedo, Paula; Lopes, Luisa; Outeiro, Tiago. "Role of type I IL-1R in a transgenic mouse model of alpha-synucleinopathies". Paper presented in CSHL conference on Neurodegenerative Diseases: Biology & Therapeutics, 2014.
  7. Soares, Rui S.; Ana Correia; Outeiro, Tiago. "Zebrafish as a model for studying Parkinson¿s disease.". Paper presented in 17th Multidisciplinary International Conference of Neuroscience and Biological Psychiatry "Stress and Behavior", 2012.
  8. Pais, Teresa Faria; Machado Oliveira, Rita; Marijanovic, Zrinka; Patrícia S, Guerreiro; Oliveira, Ana Osório; Outeiro, Tiago. "Aging and Neurodegeneration: Common Targets, Common Hopes". Paper presented in World Parkinson Congress, 2009.
  9. Pais, Teresa Faria; Guerreiro, Patrícia; Marques, Oldriska; Outeiro, Tiago. "Sirtuins: a link between ageing and microglial cell neurotoxicity". Paper presented in Annual meeting of the Society for Neurosciences, 2009.
Journal article
  1. Tiago F. Outeiro; Lorraine V. Kalia; Erwan Bezard; Juan Ferrario; Chin-Hsien Lin; Mohamed Salama; David G. Standaert; et al. "Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice". Movement Disorders (2024): https://doi.org/10.1002/mds.29802.
    10.1002/mds.29802
  2. Liana Shvachiy; Ângela Amaro-Leal; Filipa Machado; Isabel Rocha; Tiago F. Outeiro; Vera Geraldes. "Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures". Biomedicines (2024): https://doi.org/10.3390/biomedicines12040711.
    10.3390/biomedicines12040711
  3. Evelini Plácido; David J. Koss; Tiago Fleming Outeiro; Patricia S. Brocardo. "Altered hippocampal doublecortin expression in Parkinson's disease". Journal of Neurochemistry (2024): https://doi.org/10.1111/jnc.16101.
    10.1111/jnc.16101
  4. Juan Carlos Rubilar; Tiago Fleming Outeiro; Andrés D Klein. "The lysosomal ß-glucocerebrosidase strikes mitochondria: implications for Parkinson’s therapeutics". Brain (2024): https://doi.org/10.1093/brain/awae070.
    10.1093/brain/awae070
  5. Avika Chopra; Anthony E. Lang; Günter Höglinger; Tiago F. Outeiro. "Towards a biological diagnosis of PD". Parkinsonism & Related Disorders (2024): https://doi.org/10.1016/j.parkreldis.2024.106078.
    10.1016/j.parkreldis.2024.106078
  6. Dajana Galka; Tariq T. Ali; Alexander Bast; Marie Niederleithinger; Ellen Gerhardt; Ryo Motosugi; Eri Sakata; et al. "Inhibition of 26S proteasome activity by a-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1". Aging Cell (2024): https://doi.org/10.1111/acel.14128.
    10.1111/acel.14128
  7. Clara Bosbach; Luisa Maria Gatzemeier; Katja Ilme Bloch von Blottnitz; Annekatrin König; Ulf Diederichsen; Claudia Steinem; Tiago Fleming Outeiro. "Chemical synthesis of site-selective advanced glycation end products in a-synuclein and its fragments". Organic & Biomolecular Chemistry (2024): https://doi.org/10.1039/D4OB00225C.
    10.1039/D4OB00225C
  8. Felipe Saceanu Leser; Mirella Araújo Ribeiro; Lucas Dalsente Romano da Silva; Renato Garcia Domingues; Tiago Fleming Outeiro; Kevin Boyé; Eduardo Coelho Cerqueira; Fabiano Lacerda Carvalho; Phelippe do Carmo Gonçalves. "The relationship between anxiety and COVID-19-associated isolation and lifestyle changes in the university community as a result of the SARS-CoV-2 pandemic". Mental Health Science (2023): https://doi.org/10.1002/mhs2.48.
    10.1002/mhs2.48
  9. Tuane C. R. G. Vieira; Caroline A. Barros; Renato Domingues; Tiago Fleming Outeiro. "PrP meets alpha-synuclein: Molecular mechanisms and implications for disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15992.
    10.1111/jnc.15992
  10. Andrés D. Klein; Tiago Fleming Outeiro. "Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria". Nature Communications (2023): https://doi.org/10.1038/s41467-023-42107-7.
    10.1038/s41467-023-42107-7
  11. Daniel Oppermann Peixoto; Reykla Ramon Bittencourt; Juciano Gasparotto; Flávio Gabriel Carazza Kessler; Pedro Ozorio Brum; Nauana Somensi; Carolina Saibro Girardi; et al. "Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE)". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15956.
    10.1111/jnc.15956
  12. Manuel Flores-Leon; Tiago Fleming Outeiro. "More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy". Acta Neuropathologica (2023): https://doi.org/10.1007/s00401-023-02601-0.
    10.1007/s00401-023-02601-0
  13. Carmina C. Warth Perez Arias; Ivan Silbern; Lucas Caldi Gomes; Hannes Wartmann; Vivian Dambeck; Jonas Fanz; Lisa Neuenroth; et al. "Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15924.
    10.1111/jnc.15924
  14. Viviana Brembati; Gaia Faustini; Francesca Longhena; Tiago Fleming Outeiro; Arianna Bellucci. "Changes in a-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241713435.
    10.3390/ijms241713435
  15. Evelini Plácido; Priscilla Gomes Welter; Ana Wink; Gabriela Duarte Karasiak; Tiago Fleming Outeiro; Alcir Luiz Dafre; Joana Gil-Mohapel; Patricia S. Brocardo. "Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241612607.
    10.3390/ijms241612607
  16. Mario Habek; Antonela Blazekovic; Kristina Gotovac Jercic; Nela Pivac; Tiago Fleming Outero; Fran Borovecki; Vesna Brinar. "Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis". Biomedicines (2023): https://doi.org/10.3390/biomedicines11082209.
    10.3390/biomedicines11082209
  17. Avika Chopra; Tiago Fleming Outeiro. "Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies". Brain (2023): https://doi.org/10.1093/brain/awad260.
    10.1093/brain/awad260
  18. Tiago F. Outeiro; Tuane C. R. G. Vieira. "AI and protein structure and function in neurological disease: relevance to disease management". Nature Reviews Neurology (2023): https://doi.org/10.1038/s41582-023-00840-z.
    10.1038/s41582-023-00840-z
  19. Tiago F. Outeiro; Roy N. Alcalay; Angelo Antonini; Johannes Attems; Vincenzo Bonifati; Francisco Cardoso; Marie-Françoise Chesselet; et al. "Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”". Movement Disorders (2023): https://doi.org/10.1002/mds.29419.
    10.1002/mds.29419
  20. Juciano Gasparotto; Nauana Somensi; Carolina Saibro Girardi; Reykla Ramon Bittencourt; Laura Martinewski de Oliveira; Laura Piloneto Hoefel; Ingrid Matsubara Scheibel; et al. "Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15890.
    10.1111/jnc.15890
  21. Luisa Maria Gatzemeier; Franc Meyer; Ulf Diederichsen; Tiago Fleming Outeiro. "Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation". Chemistry – A European Journal (2023): https://doi.org/10.1002/chem.202300649.
    10.1002/chem.202300649
  22. Liana Shvachiy; Ângela Amaro-Leal; Tiago F. Outeiro; Isabel Rocha; Vera Geraldes. "Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation". Cells (2023): https://doi.org/10.3390/cells12050818.
    10.3390/cells12050818
  23. Luca Marsili; Jennifer Sharma; Tiago Fleming Outeiro; Carlo Colosimo. "Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials". Biomedicines (2023): https://doi.org/10.3390/biomedicines11020505.
    10.3390/biomedicines11020505
  24. Patrick W. Cullinane; Eduardo de Pablo Fernandez; Annekatrin König; Tiago Fleming Outeiro; Zane Jaunmuktane; Thomas T. Warner. "Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts". Movement Disorders (2023): https://doi.org/10.1002/mds.29298.
    10.1002/mds.29298
  25. Quesnel, Agathe; Coles, Nathan; Angione, Claudio; Dey, Priyanka; Polvikoski, Tuomo M.; Outeiro, Tiago F.; Islam, Meez; Khundakar, Ahmad A.; Filippou, Panagiota S.. "Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy". BMC Cancer (2023): https://publons.com/wos-op/publon/56741382/.
    10.1186/S12885-023-10588-W
  26. Hassanzadeh, Kambiz; Morrone, Castrese; Akhtari, Keivan; Gerhardt, Ellen; Zaccagnini, Ludovica; Outeiro, Tiago Fleming; Feligioni, Marco. "Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic". Mechanisms of Ageing and Development (2023): https://publons.com/wos-op/publon/56816349/.
    10.1016/J.MAD.2022.111759
  27. Outeiro, Tiago Fleming; El-Agnaf, Omar M.. "The immune system in Parkinson's disease: From biology to diagnosis and therapeutic targets". Neurobiology of Disease (2023): https://publons.com/wos-op/publon/56816365/.
    10.1016/J.NBD.2023.105995
  28. Aisha M. Swaih; Carlo Breda; Korrapati V. Sathyasaikumar; Natalie Allcock; Mary E. W. Collier; Robert P. Mason; Adam Feasby; et al. "Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane". Biomedicines (2022): https://doi.org/10.3390/biomedicines10092294.
    10.3390/biomedicines10092294
  29. Guaragnella, Nicoletta; Krisko, Anita; Outeiro, Tiago F.. "Editorial for the Special Issue "Adaptation, Aging, and Cell Death in Yeast Stress Response: Models, Mechanisms and Applications"". Microorganisms (2022): https://publons.com/wos-op/publon/55548779/.
    10.3390/MICROORGANISMS10061126
  30. Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago F.; Rocha, Isabel; Geraldes, Vera. "From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms". Biology (2022): https://publons.com/wos-op/publon/56816352/.
    10.3390/BIOLOGY11081164
  31. Lassen, Louise Berkhoudt; Thomsen, Maj Schneider; Basso, Elisa; Fuchtbauer, Ernst-Martin; Fuchtbauer, Annette; Outeiro, Tiago Fleming; Jensen, Poul Henning; Moos, Torben. "Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation". Cells (2022): https://publons.com/wos-op/publon/56543926/.
    10.3390/CELLS11223673
  32. Santos, Cleonice Creusa; Cardim-Pires, Thyago R.; Shvachiy, Liana; Fonseca-Fonseca, Luis Arturo; Munoz, Patricia; Almeida, Aurea Maria A. N.; Costa, Ana Carla S.; et al. "JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species". Neurotoxicity Research (2022): https://publons.com/wos-op/publon/55404800/.
    10.1007/S12640-022-00559-7
  33. Bras, Ines C.; Khani, Mohammad H.; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; van Riesen, Christoph; Urlaub, Henning; Gollisch, Tim; Outeiro, Tiago F.. "Ectosomes and exosomes modulate neuronal spontaneous activity". Journal of Proteomics (2022): https://publons.com/wos-op/publon/56816350/.
    10.1016/J.JPROT.2022.104721
  34. Vasili, Eftychia; Dominguez-Meijide, Antonio; Flores-Leon, Manuel; Al-Azzani, Mohammed; Kanellidi, Angeliki; Melki, Ronald; Stefanis, Leonidas; Outeiro, Tiago Fleming. "Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells". Molecular Neurobiology (2022): https://publons.com/wos-op/publon/52531699/.
    10.1007/S12035-021-02713-2
  35. Ghanem, Simona S.; Majbour, Nour K.; Vaikath, Nishant N.; Ardah, Mustafa T.; Erskine, Daniel; Jensen, Nanna Moller; Fayyad, Muneera; et al. "alpha-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity". Proceedings of the National Academy of Sciences (2022): https://publons.com/wos-op/publon/55106406/.
    10.1073/PNAS.2109617119
  36. Bras, Ines C.; Khani, Mohammad H.; Vasili, Eftychia; Moebius, Wiebke; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; et al. "Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity". Journal of Parkinson's Disease (2022): https://publons.com/wos-op/publon/56816361/.
    10.3233/JPD-223516
  37. Jost, Wolfgang H.; Buhmann, Carsten; Classen, Joseph; Eggert, Karla; Kohl, Zacharias; Outeiro, Tiago; Tonges, Lars; Woitalla, Dirk; Reichmann, Heinz. "Relevance of COMT inhibitors in the treatment of motor fluctuations". Der Nervenarzt (2022): https://publons.com/wos-op/publon/56816360/.
    10.1007/S00115-021-01237-3
  38. Koss, David J.; Erskine, Daniel; Porter, Andrew; Palmoski, Pawel; Menon, Hariharan; Todd, Olivia G. J.; Leite, Marta; Attems, Johannes; Outeiro, Tiago F.. "Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies". Acta Neuropathologica Communications (2022): https://publons.com/wos-op/publon/56816353/.
    10.1186/S40478-022-01403-X
  39. Cassotta, Manuela; Geerts, Hugo; Harbom, Lise; Outeiro, Tiago F.; Pediaditakis, Iosif; Reiner, Orly; Schildknecht, Stefan; et al. "The Future of Parkinson?s Disease Research A New Paradigm of Human Specific Investigation Is Necessary ... and Possible ...". ALTEX (2022): https://publons.com/wos-op/publon/56816358/.
    10.14573/ALTEX.2203161
  40. Torres-Garcia, Laura; P. Domingues, Joana M.; Brandi, Edoardo; Haikal, Caroline; Mudannayake, Janitha M.; Bras, Ines C.; Gerhardt, Ellen; et al. "Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation". Scientific Reports (2022): https://publons.com/wos-op/publon/53553098/.
    10.1038/S41598-022-06846-9
  41. Buratti, Fiamma A.; Boeffinger, Nicola; Garro, Hugo A.; Flores, Jesica S.; Hita, Francisco J.; do Carmo Goncalves, Phelippe; dos Reis Copello, Federico; et al. "Aromaticity at position 39 in alpha-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations". Protein Science (2022): https://publons.com/wos-op/publon/56816355/.
    10.1002/PRO.4360
  42. Jordan, Kate L.; Koss, David J.; Outeiro, Tiago F.; Giorgini, Flaviano. "Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease". Biomedicines (2022): https://publons.com/wos-op/publon/56816356/.
    10.3390/BIOMEDICINES10051141
  43. Chegao, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido-Ferreira, Mariana; Marques-Morgado, Ines; Fernandes Gomes, Barbara; et al. "Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes". Npj Parkinson's Disease (2022): https://publons.com/wos-op/publon/52342419/.
    10.1038/S41531-022-00314-X
  44. Shaib, A. H.; Chouaib, A. A.; Imani, V.; Chowdhury, R.; Georgiev, S. V.; Mougios, N.; Monga, M.; et al. "Expansion microscopy at one nanometer resolution". BioRxiv (2022): https://publons.com/wos-op/publon/56816351/.
    10.1101/2022.08.03.502284
  45. Al-Azzani, Mohammed; Koenig, Annekatrin; Outeiro, Tiago Fleming. "Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight". Biomolecules (2022): https://publons.com/wos-op/publon/50786423/.
    10.3390/BIOM12020324
  46. Hatton, Christopher; Ghanem, Simona S.; Koss, David J.; Abdi, Ilham Y.; Gibbons, Elizabeth; Guerreiro, Rita; Bras, Jose; et al. "Prion-like a-synuclein pathology in the brain of infants with Krabbe disease". Brain (2022): https://publons.com/wos-op/publon/56816369/.
    10.1093/BRAIN/AWAC002
  47. Schaffner, Samantha L.; Wassouf, Zinah; Lazaro, Diana F.; Xylaki, Mary; Gladish, Nicole; Lin, David T. S.; MacIsaac, Julia; et al. "Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways". Human Molecular Genetics (2022): https://publons.com/wos-op/publon/56816368/.
    10.1093/HMG/DDAC104
  48. Thom, Tobias; Schmitz, Matthias; Fischer, Anna-Lisa; Correia, Angela; Correia, Susana; Llorens, Franc; Pique, Anna-Villar; et al. "Cellular Prion Protein Mediates alpha-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo". Movement Disorders (2022): https://publons.com/wos-op/publon/49855476/.
    10.1002/MDS.28774
  49. Domingues, Renato; Sant'Anna, Ricardo; Carvalho da Fonseca, Anna Carolina; Robbs, Bruno K.; Foguel, Debora; Outeiro, Tiago F.. "Extracellular alpha-synuclein: Sensors, receptors, and responses". Neurobiology of Disease (2022): https://publons.com/wos-op/publon/51840010/.
    10.1016/J.NBD.2022.105696
  50. Magalhaes, Rayne S. S.; Boechat, Fernanda C.; Brasil, Aline A.; Neto, Jose R. M.; Ribeiro, Gabriela D.; Paranhos, Luan H.; de Souza, Natalia Neves; et al. "Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1". Journal of Cellular Biochemistry (2022): https://publons.com/wos-op/publon/56816367/.
    10.1002/JCB.30317
  51. Queiroz, Daniela D.; Ribeiro, Thales de P.; Goncalves, Julliana M.; Mattos, Larissa M. M.; Gerhardt, Ellen; Freitas, Julia; Palhano, Fernando L.; et al. "A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2022): https://publons.com/wos-op/publon/54121415/.
    10.1016/J.BBADIS.2022.166475
  52. Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago; Geraldes, Vera. "Behavioral and molecular changes resulted from different environmental lead exposures: a comparative study". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/56816366/.
  53. Pena-Diaz, Samuel; Pujols, Jordi; Vasili, Eftychia; Pinheiro, Francisca; Santos, Jaime; Manglano-Artunedo, Zoe; Outeiro, Tiago F.; Ventura, Salvador. "The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple alpha-synuclein strains". Journal of Biological Chemistry (2022): https://publons.com/wos-op/publon/54454954/.
    10.1016/J.JBC.2022.101902
  54. Rita Rosado-Ramos; Joana Godinho-Pereira; Daniela Marques; Inês Figueira; Tiago Fleming Outeiro; Regina Menezes; Cláudia Nunes dos Santos. "Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation". Molecules (2021): https://doi.org/10.3390/molecules26113353.
    10.3390/molecules26113353
  55. Tiago Fleming Outeiro. "Emerging concepts in synucleinopathies". Acta Neuropathologica (2021): https://doi.org/10.1007/s00401-021-02290-7.
    10.1007/s00401-021-02290-7
  56. Inês C. Brás; Tiago F. Outeiro. "Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies". Cells 10 2 (2021): 375-375. https://doi.org/10.3390/cells10020375.
    10.3390/cells10020375
  57. Tiago F. Outeiro; Anita Krisko. "Reply to: “Parkinson's Disease and COVID-19: Do We Need to Be More Patient?”". Movement Disorders (2021): https://doi.org/10.1002/mds.28482.
    10.1002/mds.28482
  58. David J. Koss; Odeta Bondarevaite; Sara Adams; Marta Leite; Flaviano Giorgini; Johannes Attems; Tiago F. Outeiro. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aß plaques and Lewy bodies". Brain Pathology (2021): https://doi.org/10.1111/bpa.12890.
    10.1111/bpa.12890
  59. Tiago Fleming Outeiro. "Alpha-Synuclein Antibody Characterization: Why Semantics Matters". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02269-7.
    10.1007/s12035-020-02269-7
  60. Koss, David J.; Bondarevaite, Odeta; Adams, Sara; Leite, Marta; Giorgini, Flaviano; Attems, Johannes; Outeiro, Tiago F.. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within a beta plaques and Lewy bodies". Brain Pathology (2021): https://publons.com/publon/32062536/.
    10.1111/BPA.12890
  61. Medina, Luciana; Gonzalez-Lizarraga, Florencia; Dominguez-Meijide, Antonio; Ploper, Diego; Parrales, Valeria; Sequeira, Sabrina; Cima-Omori, Maria-Sol; et al. "Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity". Frontiers in Aging Neuroscience (2021): https://publons.com/wos-op/publon/34409849/.
    10.3389/FNAGI.2021.635760
  62. Schaffner, S. L.; Wassouf, Z.; Lazaro, D. F.; Xylaki, M.; Gladish, N.; Lin, D. T. S.; MacIsaac, J.; et al. "Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways". BioRxiv (2021): https://publons.com/wos-op/publon/56816363/.
    10.1101/2021.06.12.448150
  63. Flores-Leon, Manuel; Lazaro, Diana F.; Shvachiy, Liana; Krisko, Anita; Outeiro, Tiago F.. "In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2021): https://publons.com/wos-op/publon/56816364/.
    10.1016/J.BBAPAP.2021.140693
  64. Popova, Blagovesta; Wang, Dan; Paetz, Christina; Akkermann, Dagmar; Lazaro, Diana F.; Galka, Dajana; Kolog Gulko, Miriam; et al. "DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of alpha-synuclein toxicity and oligomerization". PLOS Genetics (2021): https://publons.com/wos-op/publon/35817065/.
    10.1371/JOURNAL.PGEN.1009407
  65. Jacinto, Sandra; Guerreiro, Patricia; de Oliveira, Rita Machado; Cunha-Oliveira, Teresa; Santos, Maria Joao; Grazina, Manuela; Rego, Ana Cristina; Outeiro, Tiago F.. "MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile". Frontiers in Cellular Neuroscience (2021): https://publons.com/wos-op/publon/30853828/.
    10.3389/FNCEL.2021.641264
  66. Erskine, Daniel; Koss, David; Walker, Lauren; Outeiro, Tiago; Attems, Johannes. "Lipid metabolism alterations are associated with alpha-synuclein pathology in Lewy body dementia". Neuropathology and Applied Neurobiology (2021): https://publons.com/wos-op/publon/48287854/.
  67. Popova, Blagovesta; Wang, Dan; Rajavel, Abirami; Dhamotharan, Karthikeyan; Lazaro, Diana F.; Gerke, Jennifer; Uhrig, Joachim F.; et al. "Identification of Two Novel Peptides That Inhibit alpha-Synuclein Toxicity and Aggregation". Frontiers in Molecular Neuroscience (2021): https://publons.com/wos-op/publon/46047996/.
    10.3389/FNMOL.2021.659926
  68. Oliveira, Luis M. A.; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal A.; et al. "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease". Npj Parkinson's Disease (2021): https://publons.com/wos-op/publon/49756374/.
    10.1038/S41531-021-00203-9
  69. Wong-Guerra, Maylin; Montano-Peguero, Yanay; Ramirez-Sanchez, Jeney; Jimenez-Martin, Javier; Arturo Fonseca-Fonseca, Luis; Hernandez-Ensenat, Daniela; Nonose, Yasmine; et al. "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats". NeuroToxicology (2021): https://publons.com/wos-op/publon/49349605/.
    10.1016/J.NEURO.2021.08.017
  70. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): https://publons.com/wos-op/publon/34779767/.
    10.1080/15548627.2020.1797280
  71. Koss, David J.; Campesan, Susanna; Giorgini, Flaviano; Outeiro, Tiago F.. "Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases". Movement Disorders (2021): https://publons.com/wos-op/publon/46254551/.
    10.1002/MDS.28605
  72. Dominguez-Meijide, Antonio; Parrales, Valeria; Vasili, Eftychia; Gonzalez-Lizarraga, Florencia; Konig, Annekatrin; Lazaro, Diana F.; Lannuzel, Annie; et al. "Doxycycline inhibits alpha -synuclein-associated pathologies in vitro and in vivo". Neurobiology of Disease (2021): https://publons.com/wos-op/publon/36312904/.
    10.1016/J.NBD.2021.105256
  73. Miranda, Hugo Vicente; Szego, Eva M.; Oliveira, Luis M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. "Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies (vol 140, pg 1399, 2017)". Brain (2021): https://publons.com/wos-op/publon/50474925/.
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  74. Hatton, C.; Ghanem, S. S.; Koss, D. J.; Abdi, I. Y.; Gibbons, E.; Guerreiro, R.; Bras, J.; et al. "Prion-like α-synuclein pathology in the brains of infants: Krabbe disease as a novel seed-competent α-synucleinopathy". BioRxiv (2021): https://publons.com/wos-op/publon/56816359/.
    10.1101/2021.10.12.463948
  75. Erskine, Daniel; Koss, David; Korolchuk, Viktor I.; Outeiro, Tiago F.; Attems, Johannes; McKeith, Ian. "Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders". Acta Neuropathologica (2021): https://publons.com/wos-op/publon/40156393/.
    10.1007/S00401-021-02266-7
  76. Albert, Katrina; Raymundo, Diana P.; Panhelainen, Anne; Eesmaa, Ave; Shvachiy, Liana; Araujo, Gabriela R.; Chmielarz, Piotr; et al. "Cerebral dopamine neurotrophic factor reduces a-synuclein aggregation and propagation and alleviates behavioral alterations in vivo". Molecular Therapy (2021): https://publons.com/wos-op/publon/50745970/.
    10.1016/J.YMTHE.2021.04.035
  77. Arturo Fonseca-Fonseca, Luis; Amaral da Silva, Victor Diogenes; Wong-Guerra, Maylin; Ramirez-Sanchez, Jeney; Padron Yaquis, Alejandro Saul; Ochoa-Rodriguez, Estael; Verdecia-Reyes, Yamila; et al. "JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties". NeuroToxicology (2021): https://publons.com/wos-op/publon/40154015/.
    10.1016/J.NEURO.2020.11.005
  78. Patrícia I. Santos; Tiago F. Outeiro. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal (2020): https://doi.org/10.1111/febs.15364.
    10.1111/febs.15364
  79. Panagiota S. Filippou; Tiago F. Outeiro. "Cancer and Parkinson's Disease: Common Targets, Emerging Hopes". Movement Disorders (2020): https://doi.org/10.1002/mds.28425.
    10.1002/mds.28425
  80. Tiago Fleming Outeiro. "Alpha-synuclein oligomerization and aggregation: a model will always be a model". Journal of Neurochemistry (2020): https://doi.org/10.1111/jnc.15264.
    10.1111/jnc.15264
  81. Tiago F. Outeiro; Peter Heutink; Erwan Bezard; Angela M. Cenci. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders (2020): https://doi.org/10.1002/mds.28387.
    10.1002/mds.28387
  82. Antonio Dominguez-Meijide; Eftychia Vasili; Tiago Fleming Outeiro. "Pharmacological Modulators of Tau Aggregation and Spreading". Brain Sciences (2020): https://doi.org/10.3390/brainsci10110858.
    10.3390/brainsci10110858
  83. Tiago F. Outeiro; Anita Krisko. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders (2020): https://doi.org/10.1002/mds.28178.
    10.1002/mds.28178
  84. Alice Lippi; Renato Domingues; Cristian Setz; Tiago F. Outeiro; Anita Krisko. "SARS-CoV -2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders (2020): https://doi.org/10.1002/mds.28084.
    10.1002/mds.28084
  85. Leonor Correia Guedes; Tiago Mestre; Tiago F. Outeiro; Joaquim J. Ferreira. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry 152 5 (2020): 515-522. https://doi.org/10.1111/jnc.14902.
    10.1111/jnc.14902
  86. Tiago Fleming Outeiro. "The courage to change science". EMBO reports 21 3 (2020): https://doi.org/10.15252/embr.202050124.
    10.15252/embr.202050124
  87. Inês Caldeira Brás; Antonio Dominguez-Meijide; Ellen Gerhardt; David Koss; Diana F. Lázaro; Patrícia I. Santos; Eftychia Vasili; Mary Xylaki; Tiago Fleming Outeiro. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry (2020): https://doi.org/10.1111/jnc.14965.
    10.1111/jnc.14965
  88. Rita L. Vaz; Diana Chapela; Joana E. Coelho; Luísa V. Lopes; Joaquim J. Ferreira; Nuno D. Afonso; Sara Sousa; Tiago F. Outeiro. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience 424 (2020): 58-71. https://doi.org/10.1016/j.neuroscience.2019.08.046.
    10.1016/j.neuroscience.2019.08.046
  89. Vaz, R.L.; Sousa, S.; Chapela, D.; van der Linde, H.C.; Willemsen, R.; Correia, A.D.; Outeiro, T.F.; Afonso, N.D.. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology Biochemistry and Behavior 189 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076900575&partnerID=MN8TOARS.
    10.1016/j.pbb.2019.172828
  90. Masaracchia, C.; König, A.; Valiente-Gabioud, A.A.; Peralta, P.; Favretto, F.; Strohäker, T.; Lázaro, D.F.; et al. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta - Proteins and Proteomics 1868 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074345130&partnerID=MN8TOARS.
    10.1016/j.bbapap.2019.140298
  91. Lázaro, D.F.; Bellucci, A.; Brundin, P.; Outeiro, T.F.. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience 12 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078861604&partnerID=MN8TOARS.
    10.3389/fnmol.2019.00312
  92. Vale, N.; Alves, C.; Sharma, V.; Lázaro, D.F.; Silva, S.; Gomes, P.; Outeiro, T.F.. "A new MAP-Rasagiline conjugate reduces a-synuclein inclusion formation in a cell model". Pharmacological Reports (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079598813&partnerID=MN8TOARS.
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  93. Belo, Rita F.; Martins, Margarida L.F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". (2020): http://hdl.handle.net/10362/101849.
    https://doi.org/10.3389/fphar.2020.00985
  94. Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Inês; Garcia, Gonçalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". (2020): http://hdl.handle.net/10362/105560.
    https://doi.org/10.3390/antiox9090789
  95. Vaz, Rita L.; Chapela, Diana; Coelho, Joana E.; Lopes, Luisa, V; Ferreira, Joaquim J.; Afonso, Nuno D.; Sousa, Sara; Outeiro, Tiago F.. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience (2020): https://publons.com/publon/36281139/.
    10.1016/J.NEUROSCIENCE.2019.08.046
  96. Guedes, Leonor Correia; Mestre, Tiago; Outeiro, Tiago F.; Ferreira, Joaquim J.. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry (2020): https://publons.com/publon/28545540/.
    10.1111/JNC.14902
  97. Vaz, Rita L.; Sousa, Sara; Chapela, Diana; van der Linde, Hernia C.; Willemsen, Rob; Correia, Ana D.; Outeiro, Tiago F.; Afonso, Nuno D.. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology, Biochemistry and Behavior (2020): https://publons.com/publon/36281134/.
    10.1016/J.PBB.2019.172828
  98. Lazaro, Diana F.; Bellucci, Arianna; Brundin, Patrik; Outeiro, Tiago F.. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience (2020): https://publons.com/publon/36281135/.
    10.3389/FNMOL.2019.00312
  99. Masaracchia, Caterina; Koenig, Annekatrin; Valiente-Gabioud, Ariel A.; Peralta, Pablo; Favretto, Filippo; Strohaeker, Timo; Lazaro, Diana F.; et al. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2020): https://publons.com/publon/36281137/.
    10.1016/J.BBAPAP.2019.140298
  100. Malik, Nauman; Miah, Mohi; McAleese, Kirsty; Outeiro, Tiago; Thomas, Alan; Koss, David J.. "Contribution of amyloid and tau white matter pathology to the spatial spread of Alzheimer's disease pathology". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281129/.
  101. Placido, E.; Koss, D. J.; Brocardo, P. S.; Outeiro, T. F.. "Cell proliferation and differentiation in Parkinson's disease". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281130/.
  102. Bras, Ines Caldeira; Dominguez-Meijide, Antonio; Gerhardt, Ellen; Koss, David; Lazaro, Diana F.; Santos, Patricia, I; Vasili, Eftychia; Xylaki, Mary; Outeiro, Tiago Fleming. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry (2020): https://publons.com/publon/27892701/.
    10.1111/JNC.14965
  103. Outeiro, Tiago Fleming. "The courage to change science". EMBO Reports (2020): https://publons.com/publon/36281131/.
    10.15252/EMBR.202050124
  104. Lazaro, Diana F.; Outeiro, Tiago F.. "The Interplay Between Proteostasis Systems and Parkinson's Disease". Advances in Experimental Medicine and Biology (2020): https://publons.com/publon/36281141/.
    10.1007/978-3-030-38266-7_9
  105. Outeiro, Tiago. "Effects of pharmacological modulators of alpha-synuclein and tau aggregation and internalization". Scientific Reports (2020): https://publons.com/publon/36281118/.
    10.1038/S41598-020-69744-Y
  106. Torres, C. Alejandra Morato; Wassouf, Zinah; Zafar, Faria; Sastre, Danuta; Outeiro, Tiago Fleming; Schule, Birgitt. "The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders". International Journal of Molecular Sciences (2020): https://publons.com/publon/36281117/.
    10.3390/IJMS21165724
  107. Outeiro, Tiago. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders (2020): https://publons.com/publon/36281119/.
    10.1002/mds.28178
  108. Domingues, Renato; Lippi, Alice; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. "SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime". Aging (2020): https://publons.com/publon/34388968/.
    10.18632/AGING.103989
  109. Temido-Ferreira, Mariana; Ferreira, Diana G.; Batalha, Vsnia L.; Marques-Morgado, Ines; Coelho, Joana E.; Pereira, Pedro; Gomes, Rui; et al. "Age-related shift in LTD is dependent on neuronal adenosine A(2A)receptors interplay with mGluR5 and NMDA receptors". Molecular Psychiatry (2020): https://publons.com/publon/17854214/.
    10.1038/S41380-018-0110-9
  110. Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, Joao; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid beta Peptide-Induced Alzheimer's Disease Pathophysiology". Frontiers in Pharmacology (2020): https://publons.com/publon/33896655/.
    10.3389/FPHAR.2020.00985
  111. Vale, Nuno; Alves, Claudia; Sharma, Vaishali; Lazaro, Diana F.; Silva, Sara; Gomes, Paula; Outeiro, Tiago Fleming. "A new MAP-Rasagiline conjugate reduces alpha-synuclein inclusion formation in a cell model". Pharmacological Reports (2020): https://publons.com/publon/36281124/.
    10.1007/S43440-019-00032-X
  112. Miranda, Hugo Vicente; Chegao, Ana; Oliveira, Marcia S.; Gomes, Barbara Fernandes; Enguita, Francisco J.; Outeiro, Tiago Fleming. "Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein". The FASEB Journal (2020): https://publons.com/publon/33896656/.
    10.1096/FJ.201902936R
  113. Koss, D. J.; Erskine, D.; Attems, J.; Outeiro, T.. "Resolving the issue of nuclear localisation of alpha-synuclein in Lewy body diseases". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281127/.
  114. Koss, D. J.; Bondarevaite, O.; Adams, S.; Leite, M.; Attems, J.; Giorgini, F.; Outeiro, T.. "Determination of the pathological involvement of the vesicular trafficking protein RAB39B in idiopathic variants of neurodegenerative disease". Neuropathology and Applied Neurobiology (2020): https://publons.com/publon/36281128/.
  115. Lippi, Alice; Domingues, Renato; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. "SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders (2020): https://publons.com/publon/32314223/.
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  116. Santos, Patricia, I; Outeiro, Tiago F.. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal (2020): https://publons.com/publon/31041262/.
    10.1111/FEBS.15364
  117. Francelle, Laetitia; Outeiro, Tiago F.; Rappold, Gudrun A.. "Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity". Scientific Reports (2020): https://publons.com/publon/36281121/.
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  118. Lippi, Alice; Domingues, Renato; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. "SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders (2020): https://publons.com/publon/31478768/.
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  119. Outeiro, Tiago F.; Heutink, Peter; Bezard, Erwan; Cenci, Angela M.. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders (2020): https://publons.com/publon/36281114/.
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  120. Hentrich, Thomas; Wassouf, Zinah; Ehrhardt, Christine; Haas, Eva; Mills, James D.; Aronica, Eleonora; Outeiro, Tiago Fleming; et al. "Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients". Aging (2020): https://publons.com/publon/36281116/.
    10.18632/AGING.103935
  121. Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Ines; Garcia, Goncalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". Antioxidants (2020): https://publons.com/publon/33378118/.
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  472. Szego, E.M.; Gerhardt, E.; Outeiro, T.F.; Kermer, P.. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences 310 1-2 (2011): 90-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054111618&partnerID=MN8TOARS.
    10.1016/j.jns.2011.06.048
  473. Näsström, T.; Gonçalves, S.; Sahlin, C.; Nordström, E.; Sundquist, V.S.; Lannfelt, L.; Bergström, J.; Outeiro, T.F.; Ingelsson, M.. "Antibodies against alpha-synuclein reduce oligomerization in living cells". PLoS ONE 6 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80055113204&partnerID=MN8TOARS.
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  474. Badiola, N.; de Oliveira, R.M.; Herrera, F.; Guardia-Laguarta, C.; Gonçalves, S.A.; Pera, M.; Suárez-Calvet, M.; et al. "Tau enhances a-synuclein aggregation and toxicity in cellular models of synucleinopathy". PLoS ONE 6 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80055079219&partnerID=MN8TOARS.
    10.1371/journal.pone.0026609
  475. Marques S; Batalha VL; Lopes LV; Outeiro TF. "Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.". (2011): http://europepmc.org/abstract/med/21427489.
    10.3233/JAD-2011-110032
  476. Gerhardt, E.; Gräber, S.; Szego, E.M.; Moisoi, N.; Martins, L.M.; Outeiro, T.F.; Kermer, P.. "Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice". PLoS ONE 6 12 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-83655183720&partnerID=MN8TOARS.
    10.1371/journal.pone.0028855
  477. Ribeiro Morais, G.; Vicente Miranda, H.; Santos, I.C.; Santos, I.; Outeiro, T.F.; Paulo, A.. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic and Medicinal Chemistry 19 24 (2011): 7698-7710. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255178997&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.09.065
  478. Outeiro, Tiago. "Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity". Journal of Biological Chemistry (2011): https://publons.com/publon/5126043/.
    10.1074/JBC.M110.101527
  479. Jorge, Carla D.; Ventura, Rita; Maycock, Christopher; Outeiro, Tiago F.; Santos, Helena; Costa, Julia. "Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington's and Parkinson's Diseases". Neurochemical Research (2011): https://publons.com/publon/8217541/.
    10.1007/S11064-011-0440-3
  480. Outeiro, Tiago. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences (2011): https://publons.com/publon/9713533/.
    10.1016/J.JNS.2011.06.048
  481. Outeiro, Tiago. "Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells". Plos One (2011): https://publons.com/publon/9713531/.
    10.1371/JOURNAL.PONE.0027230
  482. Outeiro, Tiago. "FlAsH illuminates Aß aggregation". Nature Chemical Biology (2011): https://publons.com/publon/9713536/.
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  483. Outeiro, Tiago. "A stem-cell ageing hypothesis on the origin of Parkinson's disease". Journal of Neurology (2011): https://publons.com/publon/9713539/.
  484. Outeiro, Tiago. "Impaired Proteostasis Contributes to Renal Tubular Dysgenesis". Plos One (2011): https://publons.com/publon/9206785/.
    10.1371/JOURNAL.PONE.0020854
  485. Outeiro, Tiago. "Synaptic Dysfunction in Parkinson's Disease: From Protein Misfolding to Functional Alterations". Folding for the Synapse (2011): https://publons.com/publon/16533551/.
    10.1007/978-1-4419-7061-9_13
  486. Outeiro, Tiago. "SIRTUINS: A NOVEL LINK BETWEEN NEUROIFLAMMATION AND NEURODEGENERATION". Glia (2011): https://publons.com/publon/9713537/.
  487. Correia Guedes, L.; Lobo, P.; Valadas, A.; Neutel, D.; Mestre, T.; Coelho, M.; Rosa, M. M.; et al. "Non-motor symptoms in Portuguese Parkinson's disease patients". Movement Disorders (2011): https://publons.com/publon/9713535/.
  488. Outeiro, Tiago. "SIRT2 is downregulated in insulin-resistant HepG2 cells: a possible role of oxidative stress.". Molecular Biology of the Cell (2011): https://publons.com/publon/9713554/.
  489. Ellen Gerhardt; Simone Gräber; Éva M. Szego; Nicoleta Moisoi; L. Miguel Martins; Tiago F. Outeiro; Pawel Kermer. "Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice". Plos One (2011): https://publons.com/publon/9713526/.
    10.1371/JOURNAL.PONE.0028855
  490. Morais, Goreti Ribeiro; Vicente Miranda, Hugo; Santos, Isabel C.; Santos, Isabel; Outeiro, Tiago F.; Paulo, Antonio. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic & Medicinal Chemistry (2011): https://publons.com/publon/8811205/.
    10.1016/J.BMC.2011.09.065
  491. Martins, Madalena; Rosa, Alexandra; Guedes, Leonor C.; Fonseca, Benedita V.; Gotovac, Kristina; Violante, Sara; Mestre, Tiago; et al. "Convergence of miRNA Expression Profiling, alpha-Synuclein Interacton and GWAS in Parkinson's Disease". Plos One (2011): https://publons.com/publon/29642/.
    10.1371/JOURNAL.PONE.0025443
  492. Marques, Sueli C. F.; Oliveira, Catarina R.; Pereira, Claudia M. F.; Outeiro, Tiago F.. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry (2011): https://publons.com/publon/6041261/.
    10.1016/J.PNPBP.2010.08.008
  493. Badiola, Nahuai; de Oliveira, Rita Machado; Herrera, Federico; Guardia-Laguarta, Cristina; Goncalves, Susana A.; Pera, Marta; Suarez-Calvet, Marc; et al. "Tau Enhances alpha-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy". Plos One (2011): https://publons.com/publon/6846882/.
    10.1371/JOURNAL.PONE.0026609
  494. Kazantsev AG; Outeiro TF. "Drug discovery for CNS disorders: from bench to bedside.". (2010): http://europepmc.org/abstract/med/20942783.
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  495. Diógenes MJ; Outeiro TF. "Neurotrophic factors as a protective strategy in Parkinson's disease.". (2010): http://europepmc.org/abstract/med/20942787.
    10.2174/187152710793237449
  496. de Oliveira RM; Pais TF; Outeiro TF. "Sirtuins: common targets in aging and in neurodegeneration.". (2010): http://europepmc.org/abstract/med/20840069.
    10.2174/1389450111007011270
  497. Tenreiro, S.; Outeiro, T.F.. "Simple is good: Yeast models of neurodegeneration". FEMS Yeast Research 10 8 (2010): 970-979. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349294528&partnerID=MN8TOARS.
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  498. Kazantsev, A.G.; Outeiro, T.F.. "Drug discovery for cns disorders: From bench to bedside". CNS and Neurological Disorders - Drug Targets 9 6 (2010): 668-668. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649337104&partnerID=MN8TOARS.
  499. Diógenes, M.J.; Outeiro, T.F.. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets 9 6 (2010): 754-763. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649251977&partnerID=MN8TOARS.
  500. Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F.. "Alzheimer's disease: The quest to understand complexity". Journal of Alzheimer's Disease 21 2 (2010): 373-383. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957352488&partnerID=MN8TOARS.
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  501. da Costa, G.; Guerreiro, A.; Correia, C.F.; Gomes, R.J.; Freire, A.; Monteiro, E.; Barroso, E.; et al. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics - Clinical Applications 4 6-7 (2010): 674-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955783949&partnerID=MN8TOARS.
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  502. Miranda, H.V.; Outeiro, T.F.. "The sour side of neurodegenerative disorders: The effects of protein glycation". Journal of Pathology 221 1 (2010): 13-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950989148&partnerID=MN8TOARS.
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  503. Su, L.J.; Auluck, P.K.; Outeiro, T.F.; Yeger-Lotem, E.; Kritzer, J.A.; Tardiff, D.F.; Strathearn, K.E.; et al. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". DMM Disease Models and Mechanisms 3 3-4 (2010): 194-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949438990&partnerID=MN8TOARS.
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  504. Büttner, S.; Delay, C.; Franssens, V.; Bammens, T.; Ruli, D.; Zaunschirm, S.; de Oliveira, R.M.; et al. "Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a sir2-dependent manner". PLoS ONE 5 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78149449581&partnerID=MN8TOARS.
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  505. Gonçalves, S.A.; Matos, J.E.; Outeiro, T.F.. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences 35 11 (2010): 643-651. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049259996&partnerID=MN8TOARS.
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  506. Nakhjavani, M.; Morteza, A.; Khajeali, L.; Esteghamati, A.; Khalilzadeh, O.; Asgarani, F.; Outeiro, T.F.. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones 15 6 (2010): 959-964. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149434868&partnerID=MN8TOARS.
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  507. de Oliveira, R.M.; Pais, T.F.; Outeiro, T.F.. "Irtuins: Common targets in aging and in neurodegeneration". Current Drug Targets 11 10 (2010): 1270-1280. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958001297&partnerID=MN8TOARS.
  508. Nakhjavani, Manouchehr; Morteza, Afsaneh; Khajeali, Leila; Esteghamati, Alireza; Khalilzadeh, Omid; Asgarani, Firouzeh; Outeiro, Tiago F.. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones (2010): https://publons.com/publon/7283830/.
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  509. Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F.. "Epigenetics and Neurodegeneration: A Connection Overlooked". Epigenetics: Mechanism, Functions and Human Effects (2010): https://publons.com/publon/12719845/.
  510. Outeiro, Tiago. "B07 Identification of protein interaction partners for kynurenine 3-monooxygenase, a candidate therapeutic target for Huntington's disease". Journal of Neurology, Neurosurgery & Psychiatry (2010): https://publons.com/publon/9713564/.
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  511. Outeiro, Tiago. "The sour side of neurodegenerative disorders: the effects of protein glycation". The Journal of Pathology (2010): https://publons.com/publon/8811201/.
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  512. Outeiro, Tiago. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". Disease Models & Mechanisms (2010): https://publons.com/publon/9713562/.
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  513. Outeiro, Tiago. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics – Clinical Applications (2010): https://publons.com/publon/9713563/.
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  514. Outeiro, Tiago. "Simple is good: yeast models of neurodegeneration". FEMS Yeast Research (2010): https://publons.com/publon/9713559/.
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  516. Outeiro, Tiago. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets (2010): https://publons.com/publon/9713560/.
  517. Outeiro, Tiago. "Drug discovery for CNS disorders: from bench to bedside". CNS and Neurological Disorders - Drug Targets (2010): https://publons.com/publon/9713556/.
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  521. Outeiro TF; Klucken J; Bercury K; Tetzlaff J; Putcha P; Oliveira LM; Quintas A; McLean PJ; Hyman BT. "Dopamine-induced conformational changes in alpha-synuclein.". (2009): http://europepmc.org/abstract/med/19730729.
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  523. Outeiro, Tiago. "Intracellular signaling - cellular models to investigate alpha-synuclein function and dysfunction". Journal of Neurochemistry (2009): https://publons.com/publon/9713573/.
  524. Oldriska, Marques; Oliveira Rita, M.; Ferreira, Moita Luis; Fleming, Outeiro Tiago. "Sirtuins as a link between ageing and neurodegeneration". New Trends in Alzheimer and Parkinson Related Disorders: ADPD (2009): https://publons.com/wos-op/publon/12263479/.
  525. Outeiro, T.F.. "From mad cows to neurotic yeast: Novel molecular approaches to understand neurodegeneration". Microscopy and Microanalysis 14 SUPPL. 3 (2008): 105-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-53349095634&partnerID=MN8TOARS.
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  526. Tetzlaff, J.E.; Putcha, P.; Outeiro, T.F.; Ivanov, A.; Berezovska, O.; Hyman, B.T.; McLean, P.J.. "CHIP targets toxic a-synuclein oligomers for degradation". Journal of Biological Chemistry 283 26 (2008): 17962-17968. http://www.scopus.com/inward/record.url?eid=2-s2.0-49649125680&partnerID=MN8TOARS.
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  527. Outeiro, T.F.; Marques, O.; Kazantsev, A.. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1782 6 (2008): 363-369. http://www.scopus.com/inward/record.url?eid=2-s2.0-43749121572&partnerID=MN8TOARS.
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  528. Outeiro TF; Putcha P; Tetzlaff JE; Spoelgen R; Koker M; Carvalho F; Hyman BT; McLean PJ. "Correction: Formation of Toxic Oligomeric ?-Synuclein Species in Living Cells.". (2008): http://europepmc.org/abstract/PMC/PMC2556498.
  529. Mollenhauer, B.; Cullen, V.; Kahn, I.; Krastins, B.; Outeiro, T.F.; Pepivani, I.; Ng, J.; et al. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology 213 2 (2008): 315-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-49449105990&partnerID=MN8TOARS.
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  530. Fleming, J.; Outeiro, T.F.; Slack, M.; Lindquist, S.L.; Bulawa, C.E.. "Detection of Compounds That Rescue Rab1-Synuclein Toxicity". Methods in Enzymology 439 (2008): 339-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549104669&partnerID=MN8TOARS.
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  531. Outeiro TF; Kazantsev A. "Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies.". (2008): http://europepmc.org/abstract/med/19787096.
  532. Outeiro, T.F.; Kazantsev, A.. "Drug targeting of a-synuclein oligomerization in synucleinopathies". Perspectives in Medicinal Chemistry 2008 2 (2008): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953408910&partnerID=MN8TOARS.
  533. Outeiro, T.F.; Putcha, P.; Tetzlaff, J.E.; Spoelgen, R.; Koker, M.; Carvalho, F.; Hyman, B.T.; McLean, P.J.. "Formation of toxic oligomeric a-synuclein species in living cells". PLoS ONE 3 4 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-44849125207&partnerID=MN8TOARS.
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  534. Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. "Yeast as a model for studying human neurodegenerative disorders". Biotechnology Journal 3 3 (2008): 325-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549104948&partnerID=MN8TOARS.
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  535. Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. "Erratum: Yeast as a model for studying human neurodegenerative disorders (Biotechnology Journal (2008) vol. 3 (325-338))". Biotechnology Journal 3 3 (2008): 421-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549148358&partnerID=MN8TOARS.
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  536. Kazantsev, A. G.; Outeiro, T. F.; Amore, A. M.; Pallos, J.; Kontopoulos, E.; Atmann, S.; Kufareva, I.; et al. "Development small molecule inhibitors of deacetylasee sirtuin 2 for treatment aggregate-associated neurodegenerative diseases". Journal of Neurochemistry (2008): https://publons.com/publon/9713450/.
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  539. Outeiro, Tiago Fleming; Putcha, Preeti; Tetzlaff, Julie E.; Spoelgen, Robert; Koker, Mirjam; Carvalho, Filipe; Hyman, Bradley T.; McLean, Pamela J.. "Formation of Toxic Oligomeric alpha-Synuclein Species in Living Cells". Plos One (2008): https://publons.com/publon/9713571/.
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  540. Outeiro, Tiago Fleming; Marques, Oldriska; Kazantsev, Aleksey. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2008): https://publons.com/publon/9713454/.
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  542. St Martin, J.L.; Klucken, J.; Outeiro, T.F.; Nguyen, P.; Keller-McGandy, C.; Cantuti-Castelvetri, I.; Grammatopoulos, T.N.; et al. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry 100 6 (2007): 1449-1457. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847699408&partnerID=MN8TOARS.
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  543. Fleming Outeiro, T.; Tetzlaff, J.. "Mechanisms of Disease II: Cellular Protein Quality Control". Seminars in Pediatric Neurology 14 1 (2007): 15-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847188168&partnerID=MN8TOARS.
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  544. Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. "Protein aggregation disorders". Neurobiology of Disease (2007): 111-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-47749092473&partnerID=MN8TOARS.
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  545. Grammatopoulos, T.N.; Outeiro, T.F.; Hyman, B.T.; Standaert, D.G.. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications 363 3 (2007): 846-851. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848821185&partnerID=MN8TOARS.
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  546. Outeiro, T.F.; Kontopoulos, E.; Altmann, S.M.; Kufareva, I.; Strathearn, K.E.; Amore, A.M.; Volk, C.B.; et al. "Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease". Science 317 5837 (2007): 516-519. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547599329&partnerID=MN8TOARS.
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  547. Outeiro, T.F.; Grammatopoulos, T.N.; Altmann, S.; Amore, A.; Standaert, D.G.; Hyman, B.T.; Kazantsev, A.G.. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models". Biochemical and Biophysical Research Communications 357 3 (2007): 596-602. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247549725&partnerID=MN8TOARS.
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  548. Outeiro, Tiago. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models". Biochemical and Biophysical Research Communications (2007): https://publons.com/publon/9713461/.
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  549. Outeiro, Tiago. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry (2007): https://publons.com/publon/9713460/.
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  550. Outeiro, Tiago. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications (2007): https://publons.com/publon/9713449/.
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  551. Outeiro, Tiago Fleming; Kontopoulos, Eirene; Altmann, Stephen M.; Kufareva, Irina; Strathearn, Katherine E.; Amore, Allison M.; Volk, Catherine B.; et al. "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science (2007): https://publons.com/publon/9713462/.
    10.1126/SCIENCE.1143780
  552. Outeiro TF. "A bridge from Portugal to the States.". (2006): http://europepmc.org/abstract/med/17001768.
  553. Outeiro, T.F.. "A bridge from Portugal to the States.". Nature. 443 7107 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33749364368&partnerID=MN8TOARS.
  554. Bodner, R.A.; Outeiro, T.F.; Altmann, S.; Maxwell, M.M.; Cho, S.H.; Hyman, B.T.; McLean, P.J.; et al. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences of the United States of America 103 11 (2006): 4246-4251. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645235438&partnerID=MN8TOARS.
    10.1073/pnas.0511256103
  555. Outeiro, T.F.; Giorgini, F.. "Yeast as a drug discovery platform in Huntington's and Parkinson's diseases". Biotechnology Journal 1 3 (2006): 258-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749009306&partnerID=MN8TOARS.
    10.1002/biot.200500043
  556. Outeiro, T.F.; Klucken, J.; Strathearn, K.E.; Liu, F.; Nguyen, P.; Rochet, J.-C.; Hyman, B.T.; McLean, P.J.. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications 351 3 (2006): 631-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751216491&partnerID=MN8TOARS.
    10.1016/j.bbrc.2006.10.085
  557. Klucken, J.; Outeiro, T.F.; Nguyen, P.; McLean, P.J.; Hyman, B.T.. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". FASEB Journal 20 12 (2006): 2050-2057. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750117120&partnerID=MN8TOARS.
    10.1096/fj.05-5422com
  558. Bodner, RA; Outeiro, TF; Altmann, S; Maxwell, MM; Cho, SH; Hyman, BT; McLean, PJ; et al. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences (2006): https://publons.com/publon/9713442/.
    10.1073/PNAS.0511256103
  559. Outeiro, Tiago. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications (2006): https://publons.com/publon/9713459/.
    10.1016/J.BBRC.2006.10.085
  560. Outeiro, Tiago. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". The FASEB Journal (2006): https://publons.com/publon/9713457/.
    10.1096/FJ.05-5422COM
  561. Lindquist, S.; Fraenkel, E.; Outeiro, T.; Gitler, A.; Su, J.; Cashikar, A.; Jagadish, S.. "Yeast cells as a discovery platform for neurodegenerative disease". Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science) 3500 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-26444497156&partnerID=MN8TOARS.
  562. Outeiro, Tiago. "Yeast cells as a discovery platform for neurodegenerative disease". Research in Computational Molecular Biology, Proceedings (2005): https://publons.com/publon/9713456/.
    10.1007/11415770_8
  563. Rochet JC; Outeiro TF; Conway KA; Ding TT; Volles MJ; Lashuel HA; Bieganski RM; Lindquist SL; Lansbury PT. "Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.". (2004): http://europepmc.org/abstract/med/15126689.
    10.1385/JMN:23:1-2:023
  564. Outeiro TF; Muchowski PJ. "Molecular genetics approaches in yeast to study amyloid diseases.". (2004): http://europepmc.org/abstract/med/15126692.
    10.1385/JMN:23:1-2:049
  565. Derkatch, I.L.; Uptain, S.M.; Outeiro, T.F.; Krishnan, R.; Lindquist, S.L.; Liebman, S.W.. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences of the United States of America 101 35 (2004): 12934-12939. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444312783&partnerID=MN8TOARS.
    10.1073/pnas.0404968101
  566. Outeiro, T.F.; Muchowski, P.J.. "Molecular genetics approaches in yeast to study amyloid diseases". Journal of Molecular Neuroscience 23 1-2 (2004): 49-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669436&partnerID=MN8TOARS.
  567. Rochet, J.-C.; Outeiro, T.F.; Conway, K.A.; Ding, T.T.; Volles, M.J.; Lashuel, H.A.; Bieganski, R.M.; Lindquist, S.L.; Lansbury Jr., P.J.. "Interactions among a-synuclein, dopamine, and biomembranes: Some clues for understanding neurodegeneration in Parkinson's disease". Journal of Molecular Neuroscience 23 1-2 (2004): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344641972&partnerID=MN8TOARS.
  568. Da Cruz E Silva, E.F.; Outeiro, T.F.; Da Cruz E Silva, O.A.B.. "Symposium on novel therapeutic opportunities for neurodegenerative disease". Journal of Molecular Neuroscience 23 1-2 (2004): 1-2. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892653827&partnerID=MN8TOARS.
    10.1385/JMN:23:1-2:001
  569. Outeiro, Tiago. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences (2004): https://publons.com/publon/9713441/.
    10.1073/PNAS.0404968101
  570. Willingham, S.; Outeiro, T.F.; DeVit, M.J.; Lindquist, S.L.; Muchowski, P.J.. "Yeast Genes that Enhance the Toxicity of a Mutant Huntingtin Fragment or a-Synuclein". Science 302 5651 (2003): 1769-1772. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345189365&partnerID=MN8TOARS.
    10.1126/science.1090389
  571. Outeiro, T.F.; Lindquist, S.. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science 302 5651 (2003): 1772-1775. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345189364&partnerID=MN8TOARS.
    10.1126/science.1090439
  572. Resende, C.G.; Outeiro, T.F.; Sands, L.; Lindquist, S.; Tuite, M.F.. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology 49 4 (2003): 1005-1017. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041563922&partnerID=MN8TOARS.
    10.1046/j.1365-2958.2003.03608.x
  573. Resende, CG; Outeiro, TF; Sands, L; Lindquist, S; Tuite, MF. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology (2003): https://publons.com/publon/9713444/.
    10.1046/J.1365-2958.2003.03608.X
  574. Outeiro, Tiago. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science (2003): https://publons.com/publon/9713446/.
    10.1126/SCIENCE.1090439
  575. Outeiro, Tiago. "Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or -Synuclein". Science (2003): https://publons.com/publon/9713445/.
    10.1126/SCIENCE.1090389
Journal issue
  1. Belo Fernandes, Júlio; Godinho, Catarina; Baixinho, Cristina Lavareda; Outeiro, Tiago. "One Health Care in Psychiatric and Neurological Diseases". Frontiers in Psychiatry (2023):
  2. Fernandes, J. B. ; Godinho, Catarina; Baixinho, Cristina Lavareda; Outeiro, Tiago. "Personalized Care in Neurological Diseases". Frontiers in Human Neuroscience (2022):
Preprint
  1. Ricardo Sant’Anna; Bruno K Robbs; Júlia Araújo de Freitas; Patrícia Pires dos Santos; Annekatrin König; Tiago Fleming Outeiro; Debora Foguel. "Alpha-synuclein oligomers activate NFAT proteins modulating synaptic homeostasis and apoptosis". 2023. https://doi.org/10.1101/2023.02.21.529374.
    10.1101/2023.02.21.529374
  2. Anton Emil Dorn; Emile de Bruyn; Giulia Rossetti; Claudio Fernandez; Tiago F. Outeiro; Jörg B. Schulz; Paolo Carloni. "Impact of Phosphorylation on alpha-Synuclein Structural Determinants". 2023. https://doi.org/10.1101/2023.03.10.531864.
    10.1101/2023.03.10.531864
  3. Günter U. Höglinger; Charles H. Adler; Daniela Berg; Christine Klein; Tiago F. Outeiro; Werner Poewe; Ronald Postuma; Jon Stoessl; Anthony E. Lang. "Towards a Biological Definition of Parkinson’s Disease". 2023. https://doi.org/10.20944/preprints202304.0108.v1.
    10.20944/preprints202304.0108.v1
  4. Ruxanda Lungu; Francisca F. Fernandes; Tiago F. Outeiro; Noam Shemesh. "Brain-wide sensory aberrations in a Parkinson’s Disease mouse model revealed by functional MRI". 2022. https://doi.org/10.1101/2022.04.06.487227.
    10.1101/2022.04.06.487227
  5. Eftychia Vasili; Antonio Dominguez-Meijide; Manuel Flores-Léon; Mohammed Al-Azzani; Angeliki Kanellidi; Ronald Melki; Leonidas Stefanis; Tiago Outeiro. "Endogenous Levels of Alpha-synuclein Modulate Seeding and Aggregation in Cultured Cells". 2021. https://doi.org/10.21203/rs.3.rs-1152192/v1.
    10.21203/rs.3.rs-1152192/v1
  6. David J. Koss; Daniel Erskine; Andrew Porter; Pawel Palmoski; Marta Leite; Johannes Attems; Tiago F. Outeiro. "Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies". 2021. https://doi.org/10.1101/2021.10.20.465125.
    10.1101/2021.10.20.465125
Thesis / Dissertation
  1. Dionísio, Pedro A.. "Tuning cell death and inflammation in parkinson's disease". PhD, 2020. http://hdl.handle.net/10451/42843.
  2. Ferreira, Mariana Temido Mendes. "The role of A2A receptors in cognitive decline : decoding the molecular shift towards neurodegeneration". PhD, 2018. http://hdl.handle.net/10451/37953.
  3. Vaz, Rita Leitão Landeiro, 1988-. "Screening and validation of molecules with therapeutic properties in in vivo models of parkinson’s disease". PhD, 2018. http://hdl.handle.net/10451/37407.
  4. Branco-Santos, J. "The role of post-translational modifications on the oligomerization, aggregation and toxicity of mutant huntingtin". PhD, 2018. http://hdl.handle.net/10451/38930.
  5. Oliveira, Ana Cristina Osório Marinho. ""Deciphering the role of aß-crystallin in huntington’s disease"". PhD, 2017. http://hdl.handle.net/10451/28882.
  6. Gonçalves, Susana Alexandra de Barros, 1983-. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". PhD, 2017. http://hdl.handle.net/10451/28406.
  7. Gonçalves, Susana Alexandra de Barros, 1983-. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". PhD, 2017. http://hdl.handle.net/10451/28406.
  8. Silva, Ana Maria Ferreira da, 1983-. "Use of genomic dna-reporter tools to dissect pathological mechanisms caused by GAA expansions in Friedreich’s Ataxia". PhD, 2016. http://hdl.handle.net/10451/25153.
  9. Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. "The interplay between alpha-synuclein and ATP13A2 : towards the understanding of the molecular basis of Parkinson’s disease". PhD, 2016. http://hdl.handle.net/10451/28900.
  10. Brás, Inês Filipa Caldeira. "Molecular insights into the role of alfa-synuclein phosphorylation in synucleinopathies". Master, 2016. http://hdl.handle.net/10451/27689.
  11. Dias, Ana Rita Abrantes. "The role of sirtuin 2 in oligodendroglia on dopaminergic neuron differentiation and regeneration". Master, 2016. http://hdl.handle.net/10316/41275.
  12. Guerreiro, Patricia I. da Silva. "The role of LRRK2 in Parkinson’s disease : from function to dysfunction". PhD, 2015. http://hdl.handle.net/10451/22717.
  13. Geraldes, Vera Lúcia Poço, 1983-. "Hypothalamic and medullar mechanisms for long-term autonomic regulation of arterial blood pressure". PhD, 2014. http://hdl.handle.net/10451/15834.
  14. Fleming, Maria Leonor Lemos Pereira Miller, 1983-. "Deciphering the molecular role of DJ-1 in the etiology of Parkinson’s and Huntingtons’s disease". PhD, 2014. http://hdl.handle.net/10451/15629.
  15. Basso, Elisa, 1983-. "The role of alpha-synuclein phosphorylation in synucleinopathies". PhD, 2014. http://hdl.handle.net/10451/15477.
  16. Vittori, Angelica. "Copy number variation and Huntington’s disease". PhD, 2014. http://hdl.handle.net/10451/15627.
  17. Silva, Filipa Magalhães, 1990-. "Alpha-synuclein phosphorylation role on Parkinson’s disease". Master, 2013. http://hdl.handle.net/10451/10070.
  18. Amaral, Marta Isabel Magalhães Mota do, 1984-. "Structure and mechanism of kynurenine 3-monooxygenase, a candidate huntington’s disease drug target". PhD, 2013. http://hdl.handle.net/10451/9898.
  19. Oliveira, Márcia Santos. "Modulation of a-synuclein aggregation and toxicity". Master, 2013. http://hdl.handle.net/10362/11195.
  20. Martinho, Renato Gomes da Silva, 1990-. "SIRT2: in the crossroad of aging, neurodegeneration and autophagy". Master, 2013. http://hdl.handle.net/10451/9610.
  21. Rodrigues, Eva Sofia Ferreira. "Comparative study of the effect of selected mutations on alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation (BiFC) assay". Master, 2012. http://hdl.handle.net/10316/25140.
  22. Lázaro, Diana Fernandes. "Systematic comparison of the effects of a-synuclein mutations on aggregation in Parkinson’s Diseases". Master, 2012. http://hdl.handle.net/10451/7246.
  23. Santos, Joana Margarida Marques Branco dos, 1987-. "The role of N-terminal phosphorylation on Huntingtin oligomerization, aggregation and toxicity". Master, 2012. http://hdl.handle.net/10451/7554.
  24. Marques, Sueli Cristina Ferreira. "Chromatin remodeling in Alzheimer's disease pathogenesis". PhD, 2011. http://hdl.handle.net/10316/20157.
  25. Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. "Zebrafish : a new model of Parkinson's disease". Master, 2010. http://hdl.handle.net/10451/2214.
  26. Almeida, Bruno. "Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death". PhD, 2009. http://hdl.handle.net/1822/9511.
  27. Marques, Oldriska. "SIRT2 as a putative target in parkinson's disease therapy". Master, 2008. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000583288.
  28. Outeiro, Tiago Fleming de Oliveira. "Yeast as a model organism to study diseases of protein misfolding". PhD, 2004. http://hdl.handle.net/10216/10638.
Working paper
  1. Da Silva, Inês S.; Cardoso, Ana R.; Reimer, Lasse; König, Annekatrin; van Riesen, Christoph; Outeiro, Tiago; Henning Jensen, Poul; M. Goreti. F. Sales. Corresponding author: M. Goreti. F. Sales. 2022. "Molecularly imprinted polymer-based electrochemical biosensor for alpha-synuclein detection in Parkinson´s Disease (To be submitted to Biosensors and Bioelectronics)".

Intellectual property

Patent
  1. Neves, Vera; Côrte-Real, Sofia; Neves, Vera; Oliveira, Soraia; Canhão, P; Outeiro, Tiago; Castanho, Miguel; Aires-da-Silva, Frederico. 2016. "Antibody molecules and peptide delivery systems for use in Alzheimer¿s disease and related disorders". United States.
    Allowed

Other

Other output
  1. Alpha-synuclein levels modulate seeding and aggregation in cultured cells. 2021. Eftychia Vasili; Antonio Dominguez-Meijide; Manuel Flores-León; Mohammed Al-Azzani; Angeliki Kanellidi; Ronald Melki; Leonidas Stefanis; Tiago Fleming Outeiro. https://doi.org/10.21203/rs.3.rs-666210/v1.
    10.21203/rs.3.rs-666210/v1
  2. Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells. 2021. Inês Caldeira Brás; Mohammad Hossein Khani; Dietmar Riedel; Iwan Parfentev; Ellen Gerhardt; Christoph van Riesen; Henning Urlaub; Tim Gollisch; Tiago Fleming Outeiro. https://doi.org/10.1101/2021.06.24.449731.
    10.1101/2021.06.24.449731
  3. Cofilin pathology is a new player on a-synuclein-induced spine impairment in models of hippocampal synucleinopathy. 2021. MI Oliveira da Silva; M Santejo; IW Babcock; A Magalhães; LS Minamide; E Castillo; E Gerhardt; et al. https://doi.org/10.1101/2021.02.02.425931.
    10.1101/2021.02.02.425931
  4. Hsp27 reduces glycation-induced toxicity and aggregation of a-synuclein. 2020. Hugo Vicente Miranda; Ana Chegão; Márcia Oliveira; Bárbara Fernandes Gomes; Francisco J. Enguita; Tiago Fleming Outeiro. https://doi.org/10.1101/2020.03.03.975037.
    10.1101/2020.03.03.975037
  5. Effects of pharmacological modulators of a-synuclein and tau aggregation and internalization. 2020. Antonio Dominguez-Meijide; Eftychia Vasili; Annekatrin König; Maria-Sol Cima-Omori; Andrei Leonov; Sergey Ryazanov; Markus Zweckstetter; Christian Griesinger; Tiago F. Outeiro. https://doi.org/10.1101/2020.01.27.921643.
    10.1101/2020.01.27.921643
  6. Guidelines and recommendations on yeast cell death nomenclature. Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi-ni. 2018. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. http://hdl.handle.net/1822/57984.
    10.15698/mic2018.01.607
  7. (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis. Parkinson's disease (PD) is an age-related neurodegenerative disease associated with the misfolding and aggregation of alpha-synuclein (aSyn). The molecular underpinnings of PD are still obscure, but nutrition may play an important role in the prevention, onset, and disease progression. Dietary (poly)phenols revert and prevent age-related cognitive decline and neurodegeneration in model systems. H. 2018. Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. http://www.scopus.com/inward/record.url?scp=85046675039&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-018-25118-z
  8. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. 2017. Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M.A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. http://hdl.handle.net/10400.18/5439.
    Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.
  9. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin. 2017. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. http://hdl.handle.net/10400.18/5465.
    PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar.
  10. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson’s disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. 2017. Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. http://hdl.handle.net/10400.26/19438.
    Hugo Vicente Miranda, Éva M. Szego, Luís M. A. Oliveira, Carlo Breda, Ekrem Darendelioglu, Rita M. de Oliveira, Diana G. Ferreira, Marcos A. Gomes, Ruth Rott, Márcia Oliveira, Francesca Munari, Francisco J. Enguita, Tânia Simões, Eva F. Rodrigues, Michael
  11. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. 2017. Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. http://hdl.handle.net/10451/32818.
    10.1093/brain/awx056
  12. Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease. Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practic. 2017. Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. http://www.scopus.com/inward/record.url?scp=85032025050&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-017-14175-5
  13. The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. a-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the accumulation of aSyn in Lewy Bodies and Lewy neurites in disorders such as PD, dementia with Lewy bo. 2016. Lázaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina S; Tenreiro, Sandra; Ventura, Salvador; et al. http://hdl.handle.net/10362/25033.
    https://doi.org/10.1186/s40478-016-0402-8
  14. Glycation potentiates neurodegeneration in models of Huntington's disease. Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. By modifying aminogroups, glycation interferes with folding of proteins, increasing their aggregation potential. Here, we studied the effect of pharmacological and genetic manipulation of glycation on huntingtin (HTT), the causati. 2016. Miranda, Hugo Vicente; Gomes, Marcos Antonio; Branco-Santos, Joana; Breda, Carlo; Lazaro, Diana F; Lopes, Lusa Vaqueiro; Herrera, Federico; et al. http://hdl.handle.net/10362/22380.
    https://doi.org/10.1038/srep36798
  15. Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles. The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether gene expression differences in peripheral blood may be used as a signature of Parkinson's disease (PD) progression, thereby shedding light into p. 2016. Pinho, Raquel; Guedes, Leonor C; Soreq, Lilach; Lobo, Patricia P; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M; et al. http://hdl.handle.net/10362/26640.
    https://doi.org/10.1371/journal.pone.0157852
  16. A disfunção cognitiva nas doenças neurodegenerativas. As doenças neurodegenerativas são neuropatias que incluem as doenças de Parkinson (DP), de Alzheimer (DA) e de Hungtington, assim como a esclerose lateral amiotrófica e demências fronto-temporais. Podendo variar na sua patofisiologia, estas doenças estão associadas ao envelhecimento geral da população, e à presença comum de formas proteicas misfolded e agregadas no cérebro dos indivíduos afectados. 2016. Gonçalves, Susana; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6007.
  17. A levedura como modelo para estudar as bases moleculares da doença de Parkinson. A doença de Parkinson (DP) é uma doença neurodegenerativa sem cura, está associada ao envelhecimento e caracteriza-se pela acumulação de inclusões proteicas intraneuronais conhecidas como corpos de Lewy (CL) no cérebro. Os CL são inclusões maioritariamente compostas pela proteína alfa-sinucleína (aSyn), pensando-se estarem associados à neurodegeneração característica na DP. A aSyn está sujeita a v. 2016. Tenreiro, Sandra; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6006.
  18. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms of aSyn may explain the typical patterns of disease progression. However, the molecular mechanisms contro. 2016. Gonçalves, Susana A; Macedo, Diana; Raquel, Helena; Simões, Pedro D; Giorgini, Flaviano; Ramalho, José S; Barral, Duarte C; Ferreira Moita, Luís; Outeiro, Tiago Fleming. http://hdl.handle.net/10400.7/591.
    Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, et al. (2016) shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. PLoS Genet 12(4):
  19. A disfunção cognitiva nas doenças neurodegenerativas. As doenças neurodegenerativas são neuropatias que incluem as doenças de Parkinson (DP), de Alzheimer (DA) e de Hungtington, assim como a esclerose lateral amiotrófica e demências fronto-temporais. Podendo variar na sua patofisiologia, estas doenças estão associadas ao envelhecimento geral da população, e à presença comum de formas proteicas misfolded e agregadas no cérebro dos indivíduos afectados. 2016. Gonçalves, Susana; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6007.
  20. A levedura como modelo para estudar as bases moleculares da doença de Parkinson. A doença de Parkinson (DP) é uma doença neurodegenerativa sem cura, está associada ao envelhecimento e caracteriza-se pela acumulação de inclusões proteicas intraneuronais conhecidas como corpos de Lewy (CL) no cérebro. Os CL são inclusões maioritariamente compostas pela proteína alfa-sinucleína (aSyn), pensando-se estarem associados à neurodegeneração característica na DP. A aSyn está sujeita a v. 2016. Tenreiro, Sandra; Outeiro, Tiago Fleming. http://seer.upf.br/index.php/rbceh/article/view/6006.
  21. The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticos. 2016. Batalha, Vania L; Ferreira, Diana G; Coelho, Joana E.; Valadas, Jorge S; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; et al. http://hdl.handle.net/10362/22379.
    https://doi.org/10.1038/srep31493
  22. Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications. a-synuclein (a-syn) is the major component of Lewy bodies, a pathological hallmark of Parkinson's disease and other synucleinopathies. The characterization of a-syn post-translational modifications (PTMs), thought to interfere with its aggregation propensity and cellular signaling, has been limited by the availability of extraction methods of endogenous protein from cells and tissues, and by the a. 2013. Vicente Miranda, Hugo; Xiang, Wei; Oliveira, Rita M. de; Simões, Tânia; Pimentel, José; Klucken, Jochen; Penque, Deborah; Outeiro, Tiago. http://hdl.handle.net/10400.18/1729.
    doi: 10.1111/jnc.12251
  23. SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. SNCA (a-synuclein) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that SNCA has an impact on cell clearance routes and protein quality control systems such as the ubiquitin-proteasome system (UPS) and autophagy. Recent advances in the key role of the autosomal recessive PARK2/PARKIN and PINK1 genes in mitophagy. 2012. Marques, Belém Sampaio; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Márcio; Tenreiro, Sandra; Franssens, Vanessa; Reichert, Andreas S.; et al. http://hdl.handle.net/1822/21186.
    10.4161/auto.21275
  24. Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation. Parkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of t. 2012. Diógenes, Maria José; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente; Maiolino, Francesca; Guerreiro, Patrícia; Näsström, Thomas; et al. http://hdl.handle.net/10400.26/4825.
    The Journal of Neuroscience, 22 August 2012, 32(34): 11750-11762; doi: 10.1523/¿JNEUROSCI.0234-12.2012
  25. Galiza, esse lugar da Europa. Paper presented on the 6th International Anthropology Students Conference held at University Fernando Pessoa in 1998. Ponencia presentada en el 6º Congreso Internacional de Estudiantes de Antropología realizado en la Universidad Fernando Pessoa en 1998. Document présenté lors de le 6ème  Congrès International des Étudiants d'Anthropologie réalisé à l'Université Fernando Pessoa en 1998. Comunicação. 2012. Igrejas Peres, Aitor Tiago; Tobio Espinho, Paulo; Fernandes Outeiro, Paula; Malvar Fernandes, Paulo. https://revistas.rcaap.pt/antropologicas/article/view/1052.
  26. Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. Background: Parkinson’s disease is characterized by the presence of cytoplasmic inclusions, known as Lewy bodies, containing both aggregated a-synuclein and its interaction partner, synphilin-1. While synphilin-1 is known to accelerate inclusion formation by a-synuclein in mammalian cells, its effect on cytotoxicity remains elusive. Methodology/Principal Findings: We expressed wild-type synphilin-. 2010. Büttne, Sabrina; Delay, Charlotte; Franssens, Vanessa; Bammens, Tine; Ruli, Doris; Zaunschirm, Sandra; Oliveira, Rita Machado de; et al. http://hdl.handle.net/10451/6206.
    doi:10.1371/journal.pone.0013700
  27. Zooming into protein oligomerization in neurodegeneration using BiFC. Several neurodegenerative diseases are characterized by the accumulation of misfolded and aggregated proteins, which lead to neurotoxicity. However, the nature of those toxic species is controversial. Developments in optical microscopy and live-cell imaging are essential in providing crucial insight into the molecular mechanisms involved. In particular, the technique of bimolecular fluorescence co. 2010. Gonçalves, Susana A.; Matos, Joana E.; Outeiro, Tiago F.. http://dx.doi.org/10.1016/j.tibs.2010.05.007.
    http://dx.doi.org/10.1016/j.tibs.2010.05.007
  28. A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS. Purpose: To identify, characterize and perform a relative quantification of human transthyretin (TTR) variants in human saliva. Experimental design: Serum and saliva samples were collected from healthy and familial amyloidotic polyneuropathy (FAP) patients, proteins separated by SDS-PAGE, TTR bands excised, in-gel digested and analyzed by MALDI-FTICR. Results: We identified and performed a relativ. 2010. Costa, Gonçalo da; Guerreiro, Ana; Correia, Catarina F.; Gomes, Ricardo J.; Freire, António; Monteiro, Estela; Barroso, Eduardo; et al. http://hdl.handle.net/10451/6376.
    DOI 10.1002/prca.200900118
  29. A biomedicina na prevenção, diagnóstico e terapia de doenças. A biomedicina assume um papel cada vez mais importante na prevenção, diagnóstico e terapia de inúmeras doenças que afectam a população mundial, contribuindo para uma significativa melhoria das condições de vida e um consequente aumento da longevidade. A caracterização molecular das populações no contexto do seu estado de saúde, e as novas disciplinas que surgem dos avanços tecnológicos, permitem-n. 2009. Outeiro, Tiago. http://hdl.handle.net/10400.14/9872.
  30. Biomedicina na prevenção, diagnóstico e terapia de doenças. Desde que o Homem povoou a Terra que procura compreender a origem da sua existência. No ano 2000, assinalou-se um marco notável na história da Biologia, mas também da Humanidade: foi apresentada a primeira versão do código da vida humana – a sequência de DNA que constitui o genoma humano. As cerca de 3x109 (3 mil milhões) de bases de DNA que constituem o genoma humano formam os cerca de 25 mil gen. 2009. Outeiro, Tiago Fleming. http://hdl.handle.net/11144/1118.
Activities

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/03/01 - Current Bases Moleculares de Neurodegeneração Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
Distinctions

Other distinction

2015 Medalha de Ouro
2013 Medalha de Mérito - Prata
Ministério da Saúde, Mozambique
2009 EMBO Installation Grant
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
2009 Young Investigator Award
2008 Pfizer Prize for Research in Aging
2007 Research in the life sciences
Fundação Calouste Gulbenkian, Portugal
2003 Young Investigator Award
2001 Young Investigator Award
1998 Top Student in the 1998 Biochemistry Class
Fundação Engenheiro António de Almeida, Portugal
1998 Top Student in the 1998 Biochemistry Class
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal