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FMFSantos has 10 years of experience in the academia field and defines himself as a bioorganic chemist, employing a broad chemical toolbox to unravel intricate biological processes. FMFSantos completed his PhD in pharmacy (specialization in pharmaceutical and medicinal chemistry) with distinction and honors at FFUL in 2018. FMFSantos’ research work was highlighted in a news article by ASPIC and patent rights were granted to Hovione SA. Throughout his PhD, FMFSantos was awraded the young medicinal chemist in Portugal by SPQ in 2017 and invited for one international oral communication at 4th EFMC-YMCS in Vienna. Additionally, FMFSantos has also delivered three national oral communications, including 1 invited. Since 2014, FMFSantos has developed his tutoring and leadership skills with the co-supervision of 13 under- or graduated students from national and abroad universities. Additionally, his team-player and communication skills were further developed as FMFSantos has been involved as a commission staff in several national and international symposiums and was a member of postgraduate students’ commission at FFUL. Following his PhD, from 2018 to 2021, FMFSantos was a research fellow at iMed.ULisboa institute, focusing on well-defined drug delivery platforms for Alzheimer and cancer. In 2022, FMFSantos had the opportunity to transition and experience a new challenge at a pharmaceutical industry (Hovione). Despite the rewarding experience, during which his time-efficiency and problem-solving skills were further developed, FMFSantos’ passion for the academic research prompted him to become a young researcher with a CEEC position and join the teaching service at FFUL. His current research focus centers on discovering novel smart chemical entities with selective responsive activation mechanisms aimed at advancing innovative therapeutic technologies.
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Identificação

Identificação pessoal

Nome completo
Fábio Miguel Figueiredo Santos

Nomes de citação

  • Fábio M. F. Santos

Identificadores de autor

Ciência ID
8C1F-2DFC-4A67
ORCID iD
0000-0002-9057-9276
Researcher Id
B-7028-2016
Scopus Author Id
55645426300

Endereços de correio eletrónico

  • fmfsantos1987@gmail.com (Profissional)

Moradas

  • Pharmacy Faculty - Lisbon University. Av. Prof. Gama Pinto, 1649-003, Lisbon, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Orgânica
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Exatas - Química - Química Analítica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2014/03/01 - 2018/12/06
Concluído
 Farmácia (Doutoramento)
Especialização em Pharmaceutical and Medicinal chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Iminoboronates as useful scaffolds for tumor-targeting" (TESE/DISSERTAÇÃO)
 Aprovado com distinção e louvor
2009/10/06 - 2012/02/27
Concluído
 Pharmaceutical and Medicinal chemistry (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Triazene Prodrug Synthesis for MDEPT Strategy and their Hepatotoxic Evaluation" (TESE/DISSERTAÇÃO)
 17
2005/09 - 2009/08
Concluído
 Biochemistry (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Estudos Bioquímicos de uma Dps recombinante de Pseudomonas nautica 617" (TESE/DISSERTAÇÃO)
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/05 - Atual Investigador Contratado (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/01 - 2022/05 Analytical Scientist - Chemical Characterization Hovione, Portugal
2019/06/04 - 2021/12/31 Pos-Doc fellow at iMed.ULisboa_FARM-ID 7/2019/PTDC/QUI-QOR/29967/2017; Btox: Boronated Cytotoxic Multivalent Platforms - A New Concept to Fight Cancer Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2018/08/01 - 2019/06/01 Research fellow at iMed.ULisboa with a master grant (PTDC/QEQ-MED/5512/2014; Alzheimer3D: Trifunctional Conjugates for the Selective Drug Delivery in Alzheimer's disease Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014/03/01 - 2018/03/01 PhD student with a PhD scholarship (SFRH/BD/94779/2013; Iminoboronates as useful scaffolds for tumor-targeting) financed by FCT Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/05/02 - 2014/02/28 Research fellow with a master scholarship (PTDC/QUI-QUI/118315/2010; Borrow some boron: New strategies for Protein modification) financed by FCT Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/04/02 - 2013/03/31 Research fellow with a master grant (PTDC/QUI-QUI/099389/2008; Please MOC it! Metal-Organo-Catalysis an emergent concept) financed by FCT Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2007/11/24 - 2008/02/24 Monitor of Enzymatic Kinetic curricular unit during B.Sc in Biochemistry with a scientific initiation scholarships financed by FCT. Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projetos

Bolsa

Designação Financiadores
2022/01/17 - 2025/01/16 SmartBox: Engineering the first generation of ROS responsive ADCs
PTDC/QUI-OUT/3989/2021
Co-Investigador Responsável (Co-IR)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021 - 2023 Expansión de la plataforma BASHY (salicilidenhidrazonas derivadas de ácidos borónicos) y compuestos derivados: explotación innovadora de factores electrónicos y estructurales (INNO-BASHY)
PID2023-152556NB-I00
Team Member
2018/08/01 - 2019/06/01 Alzheimer3D: Trifunctional Conjugates for the Selective Drug Delivery in Alzheimer's disease
PTDC/QEQ-MED/5512/2014
Bolseiro de Mestrado
Fundação para a Ciência e a Tecnologia
Concluído
2014/03 - 2018/05 IMINOBORONATES AS USEFUL SCAFFOLDS FOR TUMOR-TARGETING
Provided by PTCRIS: SFRH/BD/94779/2013
 Fundação para a Ciência e a Tecnologia
2013/05 - 2014/02 Borrow some boron: New strategies for Protein modification
PTDC/QUI-QUI/118315/2010
Bolseiro de Mestrado
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/04 - 2013/03 Please MOC it! Metal-Organo-Catalysis an emergent concept
PTDC/QUI-QUI/099389/2008
Bolseiro de Mestrado
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/11/24 - 2008/02/24 Monitor of Enzymatic Kinetic classes during graduation in Biochemistry
...
Outra
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 REQUIMTE
Concluído

Projeto

Designação Financiadores
2025/02/03 - 2026/08/02 B-RespHonsiv: Azaboron-oxy complexes (AZABY) as an innovative linker technology for targeted drug conjugates
2023.14170.PEX
10.54499/2023.14170.PEX
Investigador responsável
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2021/06/30 PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
SAICTPAC/0019/2015
Instituto Politécnico de Leiria, Portugal

Universidade de Coimbra, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/06/04 - 2020 Btox: Boronated Cytotoxic Multivalent Platforms - A New Concept to Fight Cancer
PTDC/QUI-QOR/29967/2017
Bolseiro de Pós-Doutoramento
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 Research Institute for Medicines (iMed.ULisboa)
UID/DTP/04138/2019
154706UID
UIDB/04138/2020
UIDP/04138/2020
UIDB/04138/2020
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Ribeiro, Ana Rita; Pereira, Raquel; Barros, Catarina; Barateiro, Andreia; Alberro, Ainhoa; Basto, Afonso P.; Graça, Luís; et al. "Experimental autoimmune encephalomyelitis pathogenesis alters along animal age: impact of S100B expression". Journal of Neuroimmune Pharmacology 20 1 (2025): https://doi.org/10.1007/s11481-025-10195-5.
    10.1007/s11481-025-10195-5
  2. António, João P. M.; Roque, Inês L.; Santos, Fábio M. F.; Gois, Pedro M. P.. "Designing Functional and Responsive Molecules with Boronic Acids". Accounts of Chemical Research 58 5 (2025): 673-687. https://doi.org/10.1021/acs.accounts.4c00691.
    10.1021/acs.accounts.4c00691
  3. Joana R. M. Ferreira; Bruna F. L. Guerreiro; Fábio M. F. Santos; Samuel Guieu; M. Manuel B. Marques. "Front Cover: Exploring the Reactivity of (Hetero)aryl amides in the Chan–Evans–Lam Reaction with Arylalkenyl Boron Reagents (Eur. J. Org. Chem. 4/2025)". European Journal of Organic Chemistry (2025): https://doi.org/10.1002/ejoc.202580401.
    10.1002/ejoc.202580401
  4. Ravasco, João M.J.M.; Felicidade, João; Pinto, Maria V.; Santos, Fábio M.F.; Campos-González, René; Arteaga, Jesús F.; Mehraz, Manon; et al. "Data-Driven Discovery of a New Fluorescent BASHY Dye for Bioimaging". JACS Au 4 11 (2024): 4212-4222. https://doi.org/10.1021/jacsau.4c00473.
    10.1021/jacsau.4c00473
  5. Ferreira, Joana R. M.; Guerreiro, Bruna F. L.; Fábio M. F. Santos; Guieu, Samuel; Marques, M. Manuel B.. Autor correspondente: Marques, M. Manuel B.. "Exploring the reactivity of (hetero)aryl amides in the Chan-Evans- Lam reaction with arylalkenyl boron reagents". Invited manuscript to ChemistryOpen (submitted) (2024):
    Submetido
  6. Silva, Maria J. S. A.; Zhang, Yiyi; Vinck, Robin; Fábio M. F. Santos; António, João P. M.; Gourdon-Grünewaldt, Lisa; Zaouter, Charlotte; et al. "BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation". Bioconjugate Chemistry 34 12 (2023): 2337-2344. http://dx.doi.org/10.1021/acs.bioconjchem.3c00449.
    Aceite para publicação • 10.1021/acs.bioconjchem.3c00449
  7. Matos, Ana I.; Peres, Carina; Carreira, Barbara; Moura, Liane I. F.; Acúrcio, Rita C.; Vogel, Theresa; Wegener, Erik; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): https://doi.org/10.1002/advs.202300299.
    10.1002/advs.202300299
  8. Felicidade, João; Santos, Fabio M. F.; Arteaga, Jesús F.; Remón, Patricia; Campos-González, René; Nguyen, Ha-Chi; Nájera, Francisco; et al. "Engineering the BASHY Dye Platform toward Architectures with Responsive Fluorescence". Chemistry – A European Journal (2023): http://dx.doi.org/10.1002/chem.202300579.
    10.1002/chem.202300579
  9. Baldo, Silvia; Antunes, Patrícia; Felicidade, João Falcão; Santos, Fábio M. F.; Arteaga, Jesús F.; Fernandes, Fábio; Pischel, Uwe; Pinto, Sandra N.; Gois, Pedro M. P.. "The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib–GV1001 Conjugate". ACS Medicinal Chemistry Letters 13 1 (2021): 128-133. http://dx.doi.org/10.1021/acsmedchemlett.1c00615.
    10.1021/acsmedchemlett.1c00615
  10. Pinto, Maria V.; Santos, Fábio M. F.; Barros, Catarina; Ribeiro, Ana Rita; Pischel, Uwe; Gois, Pedro M. P.; Fernandes, Adelaide. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163. http://dx.doi.org/10.3390/cells10113163.
    10.3390/cells10113163
  11. Santos, Fábio M. F.; Domínguez, Zoe; Fernandes, João P. L.; Parente Carvalho, Cátia; Collado, Daniel; Pérez-Inestrosa, Ezequiel; Pinto, Maria V.; et al. "Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications". Chemistry – A European Journal 26 62 (2020): 14064-14069. http://dx.doi.org/10.1002/chem.202001623.
    10.1002/chem.202001623
  12. Santos, Fábio M. F.; Domínguez, Zoe; Alcaide, María M.; Matos, Ana I.; Florindo, Helena F.; Candeias, Nuno R.; Gois, Pedro M. P.; Pischel, Uwe. "Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes". ChemPhotoChem 2 12 (2018): 1038-1045. http://dx.doi.org/10.1002/cptc.201800150.
    10.1002/cptc.201800150
  13. Jiménez, V.G.; Santos, F.M.F.; Castro-Fernández, S.; Cuerva, J.M.; Gois, P.M.P.; Pischel, U.; Campaña, A.G.. "Circularly Polarized Luminescence of Boronic Acid-Derived Salicylidenehydrazone Complexes Containing Chiral Boron as Stereogenic Unit". The Journal of organic chemistry 83 22 (2018): 14057-14062. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056642547&partnerID=MN8TOARS.
    10.1021/acs.joc.8b01844
  14. Sousa, A.; Santos, F.; Gaspar, M.M.; Calado, S.; Pereira, J.D.; Mendes, E.; Francisco, A.P.; Perry, M.J.. "The selective cytotoxicity of new triazene compounds to human melanoma cells". Bioorganic and Medicinal Chemistry 25 15 (2017): 3900-3910. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020296185&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.049
  15. Alcaide, M.M.; Santos, F.M.F.; Pais, V.F.; Carvalho, J.I.; Collado, D.; Pérez-Inestrosa, E.; Arteaga, J.F.; et al. "Electronic and Functional Scope of Boronic Acid Derived Salicylidenehydrazone (BASHY) Complexes as Fluorescent Dyes". Journal of Organic Chemistry 82 14 (2017): 7151-7158. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025125313&partnerID=MN8TOARS.
    10.1021/acs.joc.7b00601
  16. Cal, P.M.S.D.; Sieglitz, F.; Santos, F.M.F.; Parente Carvalho, C.; Guerreiro, A.; Bertoldo, J.B.; Pischel, U.; Gois, P.M.P.; Bernardes, G.J.L.. "Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells". Chemical Communications 53 2 (2017): 368-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007452569&partnerID=MN8TOARS.
    10.1039/c6cc08671c
  17. Santos, F.M.F.; Matos, A.I.; Ventura, A.E.; Gonçalves, J.; Veiros, L.F.; Florindo, H.F.; Gois, P.M.P.. "Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates". Angewandte Chemie - International Edition 56 32 (2017): 9346-9350. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022198030&partnerID=MN8TOARS.
    10.1002/anie.201703492
  18. Santos, F.M.F.; Rosa, J.N.; Candeias, N.R.; Carvalho, C.P.; Matos, A.I.; Ventura, A.E.; Florindo, H.F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 5 (2016): 1631-1637. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958037809&partnerID=MN8TOARS.
    10.1002/chem.201503943
  19. Santos, Fábio M. F.; Rosa, João N.; Candeias, Nuno R.; Carvalho, Cátia Parente; Matos, Ana I.; Ventura, Ana E.; Florindo, Helena F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry – A European Journal 22 5 (2015): 1631-1637. https://doi.org/10.1002/chem.201503943.
    10.1002/chem.201503943
  20. António, J.P.M.; Frade, R.F.M.; Santos, F.M.F.; Coelho, J.A.S.; Afonso, C.A.M.; Gois, P.M.P.; Trindade, A.F.. "NHC catalysed direct addition of HMF to diazo compounds: Synthesis of acyl hydrazones with antitumor activity". RSC Advances 4 55 (2014): 29352-29356. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904087990&partnerID=MN8TOARS.
    10.1039/c4ra03710c
  21. Santos, F.M.F.; Rosa, J.N.; André, V.; Duarte, M.T.; Veiros, L.F.; Gois, P.M.P.. "N-Heterocyclic carbene catalyzed addition of aldehydes to diazo compounds: Stereoselective synthesis of N-acylhydrazones". Organic Letters 15 7 (2013): 1760-1763. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875949176&partnerID=MN8TOARS.
    10.1021/ol400563w
Capítulo de livro
  1. Antonio, J.P.M.; Farias, G.D.V.; Santos, F.M.F.; Oliveira, R.; Cal, P.M.S.D.; Gois, P.M.P.. "Boron-Nitrogen Bond: A Useful Molecular Construction Tool". 2016.
    10.1002/9781119113874.ch2
  2. Trindade, Alexandre F.; Rosa, João N.; Santos, Fábio M. F.; Gois, Pedro M. P.. "Metal-Organo Multicatalysis: An Emerging Concept". In Advances in Organometallic Chemistry and Catalysis, 325-342. John Wiley & Sons, Inc., 2013.
    10.1002/9781118742952.ch26
Poster em conferência
  1. VazPinto, Maria; Fábio M. F. Santos; Barateiro, Andreia; Brites, Dora; Pedro M. P. Gois; Fernandes, Adelaide. "BASHY dye as potential biomarker for demyelinating processes". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, 2019.
  2. VazPinto, Maria; Fábio M. F. Santos; Barateiro, Andreia; Brites, Dora; Pedro M. P. Gois; Fernandes, Adelaide. "Novel approach to characterize demyelination using newly synthesized BASHY molecules". Trabalho apresentado em 11th iMed.ULisboa Postgraduate students’ Meeting & 3rd i3DU Meeting, 2019.
  3. VazPinto, Maria; Fábio M. F. Santos; Barateiro, Andreia; Brites, Dora; Pedro M. P. Gois; Fernandes, Adelaide. "BASHY dyes: new attempt to characterize demyelination". Trabalho apresentado em IV Symposium of the Portuguese Glial Network, 2019.
  4. Fábio M. F. Santos. "Boron-promoted modular assembly of multivalent and reversible tumor-targeting drug conjugates". Trabalho apresentado em 12ENQO/5ENQT, 2018.
  5. Fábio M. F. Santos. "Modular Construction of Reversible Multivalent Targeting Drug Conjugates". Trabalho apresentado em XXV Encontro Nacional da SPQ, 2017.
  6. Fábio M. F. Santos. "Bashy complexes: Construction and characterization of boronic acid based fluorescent dyes". Trabalho apresentado em 19th European Symposium of Organic Chemistry, 2015.
  7. Fábio M. F. Santos. "Iminoboronates, an exciting approach for tumor-targeting of cytotoxic boronic acids". Trabalho apresentado em XXIII International Symposium on Medicinal Chemistry, 2014.
  8. Fábio M. F. Santos. "Stereoselective Synthesis of N-Acylhydrazones from Diazo Compounds and Aldehydes via NHC catalysis". Trabalho apresentado em 10º Portuguese National Meeting of Organic Chemistry and the 1st Portuguese-Brazilian Organic Chemistry Symposium, 2013.
  9. Fábio M. F. Santos. "Regioselective Synthesis Of N-Acylhydrazones Catalyzed by N-heterocyclic Carbenes (NHCs)”". Trabalho apresentado em 4th Postgraduate iMed.UL Students Meeting, 2012.
Tese / Dissertação
  1. Fábio M. F. Santos. "Iminoboronates as useful scaffolds for tumor-targeting". Doutoramento, Universidade de Lisboa Faculdade de Farmácia, 2018. http://hdl.handle.net/10451/37289.
  2. Santos, Fábio Miguel Figueiredo. "Triazene prodrug synthesis for MDEPT strategy and their hepatotoxic evaluation". Mestrado, 2011. http://hdl.handle.net/10451/11594.

Propriedade Intelectual

Patente
  1. Fábio M. F. Santos; Pedro M. P. Góis. 2017. "Multifunctional Boron Conjugates: Synthetic Methodology and Applications". Portugal.
  2. Fábio M. F. Santos. 2017. "Boronated multifunctional targeting drug conjugates, their uses and methods for their preparation".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025/04 BASHY: A Modular Photosensitizer Platform for Photodynamic Therapy 9thPyChem
(Faro, Portugal)
2025/03 Towards targeted mesenchymal stem cell-derived small extracellular vesicles: development of a multivalent BASHY platform iMed.Ulisboa Seminars 2024/25 – Power in Partnership: Collaborative Projects at iMed
(Lisbon, Portugal)
2024/10 B-RespHonsiv platform: Development of multivalent AZABYs as acid-labile linkers for targeted drug conjugates iMed.Ulisboa Seminars 2024/25 – From Concept to Discovery: iMed.ULisboa Exploratory Projects Series
(Lisbon, Portugal)
2024/06 BASHY modular platform: Bioimaging applications Journées d'animation scientifique du plateau de phénotypage in vivo et transparisation
(Paris, França)
2024/05 Data-driven optimization of the BASHY platform for bioimaging Biomass4Synthons - summer school at iMed.Ulisboa
(Lisbon, Portugal)
2023/10 BASHY dyes as a novel modular family of photosensitizers for PDT Cross Talks
(Lisbon, Portugal)
2023/07/25 BASHY platform: Bioimaging and Therapeutics XXVIII Encontro Nacional da SPQ
SPQ (Aveiro, Portugal)
2023/05 Multivalent and Responsive Boron-Based Platforms Therapeutics and Bioimaging Junior researcher’s meeting series at iMed.Ulisboa
(Lisbon, Portugal)
2022/07 BASHY as a valuable fluorescent linker for drug conjugates CQUL 5th Meeting - Forging Bonds
(Lisbon, Portugal)
2020 Boron's Modular Technology: Therapeutics and Bioimaging JorTec Bioquímica 2020
(Lisboa, Portugal)
2019 BASHY – A Multifunctional Modular Fluorophore Platform 4th Encontro do Colégio de Química da ULisboa
(Lisboa, Portugal)
2017 Modular Assembly of Reversible Multivalent Targeting Drug Conjugates EFMC-YMCS 2017, Young Medicinal Chemist Symposium
(Vienna, Áustria)
2017 Boron-promoted Modular Assembly of Reversible and Multivalent Tumor-Targeting Drug Conjugates 2nd Encontro do Colégio de Química da ULisboa
(Lisboa, Portugal)
2016 A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes) 8th Postgraduate iMed.ULisboa Students Meeting
(Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024 - 2028 HQ-BASHYs as an innovative multimodal platform for advanced Photodynamic Therapy; 2024.05331.BD
Coorientador
 PhD in Pharmaceutical Sciences (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2025 - 2025 Design of new boronated platforms for Photodynamic Therapy
Orientador
 Integrated Master in Pharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - 2025 BLOCKBI platform - Multifunctional and fluorescent constructs for bioimaging and therapeutics
Coorientador
 Master in Medicinal and Biopharmaceutical Chemistry (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - 2024 Ligandos multivalentes à base de boro para a síntese de bioconjugados terapêuticos
Orientador de Eduardo Filipe Fernandes dos Reis
Integrated Master's in Pharmaceutical Sciences (MICF) (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - 2024 HQ-BASHY as a novel platform for Photodynamic Therapy
Coorientador de João Francisco Alves Falcão Felicidade
Master in Medicinal and Biopharmaceutical Chemistry (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Development of new boron based fluorescent dyes as hydrogen sulphide probes
Coorientador
 Integrated Master in Pharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2017/07 - 2017/07 XXV Encontro Nacional da Sociedade Portuguesa de Quimica (XXV ENSPQ) (2017/07 - 2017/07)
Conferência (Membro da Comissão Organizadora)
2015/06 - 2015/06 6th European Conference on Chemistry in Life Sciences (6th ECCLS) (2015/06 - 2015/06)
Conferência (Membro da Comissão Organizadora)
2014/09 - 2014/09 XXIII International Symposium on Medicinal Chemistry and 1st EFMC Young Medicinal Chemist Symposium (2014/09 - 2014/09)
Conferência (Membro da Comissão Organizadora)
2013/09 - 2013/09 10th Portuguese National Meeting of Organic Chemistry and the 1st Portuguese-Brazilian Organic Chemistry Symposium (2013/09 - 2013/09)
Conferência (Membro da Comissão Organizadora)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2024/09/27 - 2024/09/27 European Researchers' Night: Participation with the iodine clock experiment to quantify vitamin C in various foods. This event aims to bridge the gap between science and society, dispelling the perception of scientific knowledge as distant or inaccessible. It provides a platform to highlight the innovative and high-quality work of Portuguese researchers, while emphasizing the critical role of clear communication between research institutions and the public.
Outro
 European Researchers' Night

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022 Targeting tumour cells usings chemical linkers with boronic acids and diazaborine scaffolds
Arguente
 Ricardo Simões Dos Santos (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 Synthesis and Evaluation of New Boronated Cytotoxic Platforms
Arguente
 João Pedro Lavado Fernandes (Mestrado)

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2017/10/02 Modular construction of cytotoxic bioconjugates with high selectivity towards cancer cells Associação Portuguesa de Investigação em Cancro (ASPIC)

Membro de associação

Nome da associação Tipo de participação
2013 - 2015 Postgraduate Students Comission (ipSC) do Instituto de Investigação do Medicamento (iMed.ULisboa) da FFULisboa Commission member

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023 - 2033 Assessment of a FFUL master student’s research project titled “BASHY, as a new tool for ChemBio”. Student name: Ana Catarina Santos Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - 2024 Assessment of a FFUL undergraduated student’s research project titled “Photochemical modification of a peptide containing a disulfide bond”. Student name: Pedro Afonso dos Reis Silva Tildes Gomes Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - 2023 Evaluation of a FFUL bachelor student’s research project titled “Synthesis of a 2-acetylphenylboronic acid derivative for the preparation of polymer bioconjugates”. Student Name: Ana Maria Narancic Marques Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2021 Evaluation of a FFUL bachelor student’s research project titled “Synthesis of iminoboronate cross linkers”. Student name: Ana Maria Narancic Marques Universidade de Lisboa Faculdade de Farmácia, Portugal

Tutoria

Tópico Nome do aluno
2024 - 2024 Lab rotation: High Performance Liquid Chromatography (HPLC) quantification to determine the concentration of specific compounds in a hydrogel formulation. Rafaela Carvalho Martins (FFUL; Targtex)
2024 - 2024 Ciência viva Sara Marcelino
2023 - 2023 Síntese de complexos de boro fotoativados para aplicações biológicas Eduardo Filipe Fernandes dos Reis
2023 - 2023 BASHY, as a new tool for ChemBio Ana Catarina Santos
2022 - 2022 BASHY as a novel platform for fluorescent and radiolabeled probes JOÃO ESTRÍBIO LEITE
2021 - 2021 Modular Synthesis of a new Fluorescent dye (BASHY) João Francisco Alves Falcão Felicidade
2020 - 2020 Modular Synthesis of a new Fluorescent dye (BASHY) João Francisco Alves Falcão Felicidade
2019 - 2019 Synthesis and Evaluation of New Boronated Cytotoxic Platforms João Pedro Lavado Fernandes
2018 - 2019 Modular Synthesis of Fluorescent Probe (BASHY) João Pedro Lavado Fernandes
2017 - 2017 Iminoboronate synthesis: Construction of BASHY dyes to be applied in bioimaging Rita Isabel Cordeiro Padanha
2017 - 2017 Modular Synthesis of Fluoresecent Probes (BASHY) for Bioimaging Applications João Manuel Oliveira Mota
2015 - 2015 Strategy for cancer cells targeting: iminoboronates conjugates and imaging probes Joana Inês Coelho de Pinho Carvalho
2015 - 2015 BASHY as hydrogen sulphide probes Joana Inês Coelho de Pinho Carvalho
2015 - 2015 Development of a pegylated building block for the assemblage of conjugates for cancer's therapy Rita Isabel Cordeiro Padanha
Distinções

Prémio

2018 Best poster presentation
12ENQO/5ENQT, Portugal

Título

2017 Young medicinal chemist in Portugal
Direcção da Divisão de Química Terapêutica da Sociedade Portuguesa Química, Portugal