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FMFSantos has 10 years of experience in the academia field and defines himself as a bioorganic chemist, employing a broad chemical toolbox to unravel intricate biological processes. FMFSantos completed his PhD in pharmacy (specialization in pharmaceutical and medicinal chemistry) with distinction and honors at FFUL in 2018. FMFSantos’ research work was highlighted in a news article by ASPIC and patent rights were granted to Hovione SA. Throughout his PhD, FMFSantos was awraded the young medicinal chemist in Portugal by SPQ in 2017 and invited for one international oral communication at 4th EFMC-YMCS in Vienna. Additionally, FMFSantos has also delivered three national oral communications, including 1 invited. Since 2014, FMFSantos has developed his tutoring and leadership skills with the co-supervision of 13 under- or graduated students from national and abroad universities. Additionally, his team-player and communication skills were further developed as FMFSantos has been involved as a commission staff in several national and international symposiums and was a member of postgraduate students’ commission at FFUL. Following his PhD, from 2018 to 2021, FMFSantos was a research fellow at iMed.ULisboa institute, focusing on well-defined drug delivery platforms for Alzheimer and cancer. In 2022, FMFSantos had the opportunity to transition and experience a new challenge at a pharmaceutical industry (Hovione). Despite the rewarding experience, during which his time-efficiency and problem-solving skills were further developed, FMFSantos’ passion for the academic research prompted him to become a young researcher with a CEEC position and join the teaching service at FFUL. His current research focus centers on discovering novel smart chemical entities with selective responsive activation mechanisms aimed at advancing innovative therapeutic technologies.
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Identification

Personal identification

Full name
Fábio Miguel Figueiredo Santos

Citation names

  • Fábio M. F. Santos

Author identifiers

Ciência ID
8C1F-2DFC-4A67
ORCID iD
0000-0002-9057-9276
Researcher Id
B-7028-2016
Scopus Author Id
55645426300

Email addresses

  • fmfsantos1987@gmail.com (Professional)

Addresses

  • Pharmacy Faculty - Lisbon University. Av. Prof. Gama Pinto, 1649-003, Lisbon, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences - Analytical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2014/03/01 - 2018/12/06
Concluded
 Farmácia (Doutoramento)
Major in Pharmaceutical and Medicinal chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Iminoboronates as useful scaffolds for tumor-targeting" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2009/10/06 - 2012/02/27
Concluded
 Pharmaceutical and Medicinal chemistry (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Triazene Prodrug Synthesis for MDEPT Strategy and their Hepatotoxic Evaluation" (THESIS/DISSERTATION)
 17
2005/09 - 2009/08
Concluded
 Biochemistry (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Estudos Bioquímicos de uma Dps recombinante de Pseudomonas nautica 617" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2022/05 - Current Contracted Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023 - 2023 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2022/01 - 2022/05 Analytical Scientist - Chemical Characterization Hovione, Portugal
2019/06/04 - 2021/12/31 Pos-Doc fellow at iMed.ULisboa_FARM-ID 7/2019/PTDC/QUI-QOR/29967/2017; Btox: Boronated Cytotoxic Multivalent Platforms - A New Concept to Fight Cancer Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2018/08/01 - 2019/06/01 Research fellow at iMed.ULisboa with a master grant (PTDC/QEQ-MED/5512/2014; Alzheimer3D: Trifunctional Conjugates for the Selective Drug Delivery in Alzheimer's disease Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014/03/01 - 2018/03/01 PhD student with a PhD scholarship (SFRH/BD/94779/2013; Iminoboronates as useful scaffolds for tumor-targeting) financed by FCT Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/05/02 - 2014/02/28 Research fellow with a master scholarship (PTDC/QUI-QUI/118315/2010; Borrow some boron: New strategies for Protein modification) financed by FCT Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/04/02 - 2013/03/31 Research fellow with a master grant (PTDC/QUI-QUI/099389/2008; Please MOC it! Metal-Organo-Catalysis an emergent concept) financed by FCT Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2007/11/24 - 2008/02/24 Monitor of Enzymatic Kinetic curricular unit during B.Sc in Biochemistry with a scientific initiation scholarships financed by FCT. Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2022/01 - 2025/01 SmartBox: Desenvolvimento da primeira geração de ADCs sensíveis a ROS
Provided by PTCRIS: PTDC/QUI-OUT/3989/2021
 Fundação para a Ciência e a Tecnologia
2017/01 - 2021/06 ONCOLOGIA DE PRECISÃO: TERAPIAS E TECNOLOGIAS INOVADORAS
Provided by PTCRIS: SAICTPAC/0019/2015
 Fundação para a Ciência e a Tecnologia
2018/08/01 - 2019/06/01 Alzheimer3D: Trifunctional Conjugates for the Selective Drug Delivery in Alzheimer's disease
PTDC/QEQ-MED/5512/2014
Master Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2014/03 - 2018/05 IMINOBORONATES AS USEFUL SCAFFOLDS FOR TUMOR-TARGETING
Provided by PTCRIS: SFRH/BD/94779/2013
 Fundação para a Ciência e a Tecnologia
2013/05 - 2014/02 Borrow some boron: New strategies for Protein modification
PTDC/QUI-QUI/118315/2010
Master Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/04 - 2013/03 Please MOC it! Metal-Organo-Catalysis an emergent concept
PTDC/QUI-QUI/099389/2008
Master Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/11/24 - 2008/02/24 Monitor of Enzymatic Kinetic classes during graduation in Biochemistry
...
Other
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 REQUIMTE
Concluded

Contract

Designation Funders
2018/07/02 - 2021/07/01 Boronated Cytotoxic Multivalent Platforms - A New Concept to Fight Cancer
PTDC/QUI-QOR/29967/2017
Researcher
Ongoing
2019/06/04 - 2020 Btox: Boronated Cytotoxic Multivalent Platforms - A New Concept to Fight Cancer
PTDC/QUI-QOR/29967/2017
Post-doc Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Antonio, J.P.M.; Farias, G.D.V.; Santos, F.M.F.; Oliveira, R.; Cal, P.M.S.D.; Gois, P.M.P.. "Boron-Nitrogen Bond: A Useful Molecular Construction Tool". 2016.
    10.1002/9781119113874.ch2
  2. Trindade, Alexandre F.; Rosa, João N.; Santos, Fábio M. F.; Gois, Pedro M. P.. "Metal-Organo Multicatalysis: An Emerging Concept". In Advances in Organometallic Chemistry and Catalysis, 325-342. John Wiley & Sons, Inc., 2013.
    10.1002/9781118742952.ch26
Conference poster
  1. Fábio M. F. Santos. "Boron-promoted modular assembly of multivalent and reversible tumor-targeting drug conjugates". Paper presented in 12ENQO/5ENQT, 2018.
  2. Fábio M. F. Santos. "Modular Construction of Reversible Multivalent Targeting Drug Conjugates". Paper presented in XXV Encontro Nacional da SPQ, 2017.
  3. Fábio M. F. Santos. "Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Paper presented in 6th EuCheMS in Life Sciences, 2016.
  4. Fábio M. F. Santos. "Bashy complexes: Construction and characterization of boronic acid based fluorescent dyes". Paper presented in 19th European Symposium of Organic Chemistry, 2015.
  5. Fábio M. F. Santos. "Iminoboronates, an exciting approach for tumor-targeting of cytotoxic boronic acids". Paper presented in XXIII International Symposium on Medicinal Chemistry, 2014.
  6. Fábio M. F. Santos. "Stereoselective Synthesis of N-Acylhydrazones from Diazo Compounds and Aldehydes via NHC catalysis". Paper presented in 10º Portuguese National Meeting of Organic Chemistry and the 1st Portuguese-Brazilian Organic Chemistry Symposium, 2013.
  7. Fábio M. F. Santos. "Regioselective Synthesis Of N-Acylhydrazones Catalyzed by N-heterocyclic Carbenes (NHCs)”". Paper presented in 4th Postgraduate iMed.UL Students Meeting, 2012.
Journal article
  1. Silva, Maria J. S. A.; Zhang, Yiyi; Vinck, Robin; Fábio M. F. Santos; António, João P. M.; Gourdon-Grünewaldt, Lisa; Zaouter, Charlotte; et al. "BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation". Bioconjugate Chemistry 34 12 (2023): 2337-2344. http://dx.doi.org/10.1021/acs.bioconjchem.3c00449.
    Accepted • 10.1021/acs.bioconjchem.3c00449
  2. Felicidade, João; Santos, Fabio M. F.; Arteaga, Jesús F.; Remón, Patricia; Campos-González, René; Nguyen, Ha-Chi; Nájera, Francisco; et al. "Engineering the BASHY Dye Platform toward Architectures with Responsive Fluorescence". Chemistry – A European Journal (2023): http://dx.doi.org/10.1002/chem.202300579.
    10.1002/chem.202300579
  3. Baldo, Silvia; Antunes, Patrícia; Felicidade, João Falcão; Santos, Fábio M. F.; Arteaga, Jesús F.; Fernandes, Fábio; Pischel, Uwe; Pinto, Sandra N.; Gois, Pedro M. P.. "The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib–GV1001 Conjugate". ACS Medicinal Chemistry Letters 13 1 (2021): 128-133. http://dx.doi.org/10.1021/acsmedchemlett.1c00615.
    10.1021/acsmedchemlett.1c00615
  4. Pinto, Maria V.; Santos, Fábio M. F.; Barros, Catarina; Ribeiro, Ana Rita; Pischel, Uwe; Gois, Pedro M. P.; Fernandes, Adelaide. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163. http://dx.doi.org/10.3390/cells10113163.
    10.3390/cells10113163
  5. Santos, Fábio M. F.; Domínguez, Zoe; Fernandes, João P. L.; Parente Carvalho, Cátia; Collado, Daniel; Pérez-Inestrosa, Ezequiel; Pinto, Maria V.; et al. "Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications". Chemistry – A European Journal 26 62 (2020): 14064-14069. http://dx.doi.org/10.1002/chem.202001623.
    10.1002/chem.202001623
  6. Santos, Fábio M. F.; Domínguez, Zoe; Alcaide, María M.; Matos, Ana I.; Florindo, Helena F.; Candeias, Nuno R.; Gois, Pedro M. P.; Pischel, Uwe. "Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes". ChemPhotoChem 2 12 (2018): 1038-1045. http://dx.doi.org/10.1002/cptc.201800150.
    10.1002/cptc.201800150
  7. Jiménez, V.G.; Santos, F.M.F.; Castro-Fernández, S.; Cuerva, J.M.; Gois, P.M.P.; Pischel, U.; Campaña, A.G.. "Circularly Polarized Luminescence of Boronic Acid-Derived Salicylidenehydrazone Complexes Containing Chiral Boron as Stereogenic Unit". The Journal of organic chemistry 83 22 (2018): 14057-14062. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056642547&partnerID=MN8TOARS.
    10.1021/acs.joc.8b01844
  8. Sousa, A.; Santos, F.; Gaspar, M.M.; Calado, S.; Pereira, J.D.; Mendes, E.; Francisco, A.P.; Perry, M.J.. "The selective cytotoxicity of new triazene compounds to human melanoma cells". Bioorganic and Medicinal Chemistry 25 15 (2017): 3900-3910. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020296185&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.049
  9. Alcaide, M.M.; Santos, F.M.F.; Pais, V.F.; Carvalho, J.I.; Collado, D.; Pérez-Inestrosa, E.; Arteaga, J.F.; et al. "Electronic and Functional Scope of Boronic Acid Derived Salicylidenehydrazone (BASHY) Complexes as Fluorescent Dyes". Journal of Organic Chemistry 82 14 (2017): 7151-7158. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025125313&partnerID=MN8TOARS.
    10.1021/acs.joc.7b00601
  10. Cal, P.M.S.D.; Sieglitz, F.; Santos, F.M.F.; Parente Carvalho, C.; Guerreiro, A.; Bertoldo, J.B.; Pischel, U.; Gois, P.M.P.; Bernardes, G.J.L.. "Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells". Chemical Communications 53 2 (2017): 368-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007452569&partnerID=MN8TOARS.
    10.1039/c6cc08671c
  11. Santos, F.M.F.; Matos, A.I.; Ventura, A.E.; Gonçalves, J.; Veiros, L.F.; Florindo, H.F.; Gois, P.M.P.. "Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates". Angewandte Chemie - International Edition 56 32 (2017): 9346-9350. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022198030&partnerID=MN8TOARS.
    10.1002/anie.201703492
  12. Santos, F.M.F.; Rosa, J.N.; Candeias, N.R.; Carvalho, C.P.; Matos, A.I.; Ventura, A.E.; Florindo, H.F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 5 (2016): 1631-1637. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958037809&partnerID=MN8TOARS.
    10.1002/chem.201503943
  13. Santos, F.M.F.; Rosa, J.N.; Candeias, N.R.; Carvalho, C.P.; Matos, A.I.; Ventura, A.E.; Florindo, H.F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 44 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84950262633&partnerID=MN8TOARS.
    10.1002/chem.201504857
  14. António, J.P.M.; Frade, R.F.M.; Santos, F.M.F.; Coelho, J.A.S.; Afonso, C.A.M.; Gois, P.M.P.; Trindade, A.F.. "NHC catalysed direct addition of HMF to diazo compounds: Synthesis of acyl hydrazones with antitumor activity". RSC Advances 4 55 (2014): 29352-29356. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904087990&partnerID=MN8TOARS.
    10.1039/c4ra03710c
  15. Santos, F.M.F.; Rosa, J.N.; André, V.; Duarte, M.T.; Veiros, L.F.; Gois, P.M.P.. "N-Heterocyclic carbene catalyzed addition of aldehydes to diazo compounds: Stereoselective synthesis of N-acylhydrazones". Organic Letters 15 7 (2013): 1760-1763. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875949176&partnerID=MN8TOARS.
    10.1021/ol400563w
Thesis / Dissertation
  1. Fábio M. F. Santos. "Iminoboronates as useful scaffolds for tumor-targeting". PhD, Universidade de Lisboa Faculdade de Farmácia, 2018.
  2. Santos, Fábio Miguel Figueiredo. "Triazene prodrug synthesis for MDEPT strategy and their hepatotoxic evaluation". Master, 2011. http://hdl.handle.net/10451/11594.

Intellectual property

Patent
  1. Fábio M. F. Santos; Pedro M. P. Góis. 2017. "Multifunctional Boron Conjugates: Synthetic Methodology and Applications". Portugal.
  2. Fábio M. F. Santos. 2017. "Boronated multifunctional targeting drug conjugates, their uses and methods for their preparation".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/07/25 BASHY platform: Bioimaging and Therapeutics XXVIII Encontro Nacional da SPQ
SPQ (Aveiro, Portugal)
2022/07 BASHY as a valuable fluorescent linker for drug conjugates CQUL 5th Meeting - Forging Bonds
(Lisbon, Portugal)
2020 Boron's Modular Technology: Therapeutics and Bioimaging JorTec Bioquímica 2020
(Lisboa, Portugal)
2019 BASHY – A Multifunctional Modular Fluorophore Platform 4th Encontro do Colégio de Química da ULisboa
(Lisboa, Portugal)
2017 Modular Assembly of Reversible Multivalent Targeting Drug Conjugates EFMC-YMCS 2017, Young Medicinal Chemist Symposium
(Vienna, Austria)
2017 Boron-promoted Modular Assembly of Reversible and Multivalent Tumor-Targeting Drug Conjugates 2nd Encontro do Colégio de Química da ULisboa
(Lisboa, Portugal)
2016 A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes) 8th Postgraduate iMed.ULisboa Students Meeting
(Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015 - 2016 Development of new boron based fluorescent dyes as hydrogen sulphide probes
Co-supervisor
 Integrated Master in Pharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/07 - 2017/07 XXV Encontro Nacional da Sociedade Portuguesa de Quimica (XXV ENSPQ) (2017/07 - 2017/07)
Conference (Member of the Organising Committee)
2015/06 - 2015/06 6th European Conference on Chemistry in Life Sciences (6th ECCLS) (2015/06 - 2015/06)
Conference (Member of the Organising Committee)
2014/09 - 2014/09 XXIII International Symposium on Medicinal Chemistry and 1st EFMC Young Medicinal Chemist Symposium (2014/09 - 2014/09)
Conference (Member of the Organising Committee)
2013/09 - 2013/09 10th Portuguese National Meeting of Organic Chemistry and the 1st Portuguese-Brazilian Organic Chemistry Symposium (2013/09 - 2013/09)
Conference (Member of the Organising Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022 Targeting tumour cells usings chemical linkers with boronic acids and diazaborine scaffolds
(Thesis) Arguer
 Ricardo Simões Dos Santos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 Synthesis and Evaluation of New Boronated Cytotoxic Platforms
(Thesis) Arguer
 João Pedro Lavado Fernandes (Master)

Association member

Society Organization name Role
2013 - 2015 Postgraduate Students Comission (ipSC) do Instituto de Investigação do Medicamento (iMed.ULisboa) da FFULisboa Commission member

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017/10/02 Modular construction of cytotoxic bioconjugates with high selectivity towards cancer cells Associação Portuguesa de Investigação em Cancro (ASPIC)

Mentoring / Tutoring

Topic Student name
2023 - 2023 Síntese de complexos de boro fotoativados para aplicações biológicas Eduardo Filipe Fernandes dos Reis
2023 - 2023 BASHY, as a new tool for ChemBio Ana Catarina Santos
2022 - 2022 BASHY as a novel platform for fluorescent and radiolabeled probes JOÃO ESTRÍBIO LEITE
2021 - 2021 Modular Synthesis of a new Fluorescent dye (BASHY) João Francisco Alves Falcão Felicidade
2020 - 2020 Modular Synthesis of a new Fluorescent dye (BASHY) João Francisco Alves Falcão Felicidade
2019 - 2019 Synthesis and Evaluation of New Boronated Cytotoxic Platforms João Pedro Lavado Fernandes
2018 - 2019 Modular Synthesis of Fluorescent Probe (BASHY) João Pedro Lavado Fernandes
2017 - 2017 Iminoboronate synthesis: Construction of BASHY dyes to be applied in bioimaging Rita Isabel Cordeiro Padanha
2017 - 2017 Modular Synthesis of Fluoresecent Probes (BASHY) for Bioimaging Applications João Manuel Oliveira Mota
2016 - 2016 BASHY as hydrogen sulphide probes Joana Inês Coelho de Pinho Carvalho
2015 - 2015 Strategy for cancer cells targeting: iminoboronates conjugates and imaging probes Joana Inês Coelho de Pinho Carvalho
2015 - 2015 Development of a pegylated building block for the assemblage of conjugates for cancer's therapy Rita Isabel Cordeiro Padanha

Other jury / evaluation

Activity description Institution / Organization
2023 - 2033 Assessment of a FFUL master student’s research project titled “BASHY, as a new tool for ChemBio”. Student name: Ana Catarina Santos Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - 2023 Evaluation of a FFUL bachelor student’s research project titled “Synthesis of a 2-acetylphenylboronic acid derivative for the preparation of polymer bioconjugates”. Student Name: Ana Maria Narancic Marques Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2021 Evaluation of a FFUL bachelor student’s research project titled “Synthesis of iminoboronate cross linkers”. Student name: Ana Maria Narancic Marques Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinctions

Award

2018 Best poster presentation
12ENQO/5ENQT, Portugal

Title

2017 Young medicinal chemist in Portugal
Direcção da Divisão de Química Terapêutica da Sociedade Portuguesa Química, Portugal