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Natália Gonçalves da Silva successfully completed her master´s degree in Environmental Contamination and Toxicology in 2018 at the University of Porto (Instituto de Ciências Biomédicas Abel Salazar). Her thesis research focused on the isolation of natural products to address the obesity and related co-morbidities challenges. Afterwards, she worked as a research fellow on the CYANOBESITY - "Cyanobacteria as a source of bioactive compounds with effects on obesity and obesity-related co-morbidities" project at the BBE (Blue Biotechnology and Ecotoxicology) laboratory from CIIMAR. As a result, she developed and strengthened several skills in a range of Biological and Chemical procedures, including (i) several microorganism cultures, (ii) chemical fractionation and natural product isolation, (iii) structure elucidation of compounds by spectroscopic and spectrometric techniques, (iv) bioactivity screenings (cell-based and zebrafish-based assays) and in vivo toxicological assays and (v) molecular characterization of compounds. Additionally, she published two papers, one of which as first author, she is co-inventor in one Provisional Patent Application with internationalization request approved and is involved in scientific dissemination (either by conference presentations or presentations in international partners meetings). Currently, she is working in CIIMAR for her doctoral degree in Marine Biotechnology and Aquaculture at the University of Porto (Faculty of Sciences). In her Ciência Vitae curriculum the most frequent key-words in the context of scientific, technological and artistic-cultural production are: Natural products; Bioactivities; Metabolic diseases; Extraction; Fractionation; Zebrafish assays;
Identificação

Identificação pessoal

Nome completo
Natália Gonçalves da Silva

Nomes de citação

  • Silva, Gonçalves Natália

Identificadores de autor

Ciência ID
571B-0A4E-24ED
ORCID iD
0000-0002-2168-6027

Endereços de correio eletrónico

  • nsilva@ciimar.up.pt (Profissional)

Telefones

Telefone
  • 223401800 (Profissional)

Moradas

  • CIIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental. Terminal de Cruzeiros de Leixões, Av. General Norton de Matos s/n, 4450-208 M, Porto, Matosinhos, Portugal (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
  • Ciências Médicas e da Saúde - Biotecnologia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2020/10 - 2025/07
Em curso
Biotecnologia Marinha e Aquacultura (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"The potential of cyanobacteria as a source of lipid-reducing metabolites: isolation, roles on lipid metabolism and metabolic targets" (TESE/DISSERTAÇÃO)
2016/09 - 2018/11
Concluído
Toxicologia e Contaminação Ambientais (Mestrado integrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Bioactivity screening of marine cyanobacteria for the isolation of novel compounds for obesity related co-morbidities" (TESE/DISSERTAÇÃO)
19
2013/09 - 2016/07
Concluído
Ciências do Meio Aquático (Licenciatura)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"n/a" (TESE/DISSERTAÇÃO)
16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2025/02 - Atual Investigador Contratado (Investigação) Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Biodiscovery for Health (B4H) group), Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2019/01/15 - 2020/07/31 Investigador (Investigação) Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2017/09/01 - 2018/11/12 Master's thesis student: project focused on natural compounds isolated from marine cyanobacteria towards obesity Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
2016/03/07 - 2016/06/17 Internship of initiation to scientific research entitled “Efeitos de contaminantes ambientais em organismos representativos de dois níveis tróficos de ecossistemas aquáticos: C. vulgaris e D. magna" Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal. Population Studies Department, Laboratory of Ecotoxicology, Stress ecology and Environmental Health, ICBAS., Portugal
Projetos

Projeto

Designação Financiadores
2019/01/15 - Atual CYANOBESITY - Cyanobacteria as a source of bioactive compounds with effects on obesity and obesity-related co-morbidities
ERA-MBT/0001/2015
Bolseiro de Investigação
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Em curso
Produções

Publicações

Artigo em revista
  1. Natália Gonçalves Silva; Marco Preto; Vitor Vasconcelos; Ralph Urbatzka. "Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism". Food & Function (2024): https://doi.org/10.1039/D3FO02915H.
    10.1039/D3FO02915H
  2. Tiago Ribeiro; Kristín Jónsdóttir; Rene Hernandez-Bautista; Natália Gonçalves Silva; Begoña Sánchez-Astráin; Afshin Samadi; Finnur F. Eiriksson; et al. "Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro Approaches". Marine Drugs (2023): https://doi.org/10.3390/md21090498.
    10.3390/md21090498
  3. Costa, Margarida; Rosa, Filipa; Ribeiro, Tiago; Hernandez-Bautista, Rene; Bonaldo, Marco; Gonçalves Silva, Natália; Eiríksson, Finnur; et al. "Identification of Cyanobacterial Strains with Potential for the Treatment of Obesity-Related Co-Morbidities by Bioactivity, Toxicity Evaluation and Metabolite Profiling". Marine Drugs 17 5 (2019): 280. http://dx.doi.org/10.3390/md17050280.
    Publicado • 10.3390/md17050280
  4. Freitas, Sara; Silva, Natália Gonçalves; Sousa, Maria Lígia; Ribeiro, Tiago; Rosa, Filipa; Leão, Pedro N.; Vasconcelos, Vitor; Reis, Mariana Alves; Urbatzka, Ralph. "Chlorophyll Derivatives from Marine Cyanobacteria with Lipid-Reducing Activities". Marine Drugs 17 4 (2019): 229-247. http://dx.doi.org/10.3390/md17040229.
    Publicado • 10.3390/md17040229
Poster em conferência
  1. Silva, Natália G.; Preto, Marco; Vasconcelos, Vítor; Urbatzka, Ralph. "The Role of Vitamin K Family in Obesity". Trabalho apresentado em 7th Iberian Congress on Cyanotoxins/3rd Iberoamerican Congress on Cyanotoxins, 2022.
    10.3390/blsf2022014036
  2. Silva, Gonçalves Natália; Preto, Marco; Vasconcelos, Vitor; Urbatzka, Ralph. "Uncovering the effects of the vitamins K family on lipid metabolism". Trabalho apresentado em Trends in Natural Products Research: A PSE Young Scientists’ Meeting (PSE-YSM2022), 2022.
  3. Silva, Gonçalves Natália; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "Validation of Bioactivity-based Molecular Networking for Anti-Obesity Natural Products Discovery". Trabalho apresentado em XII European Conference on Marine Natural Products, 2021.
  4. Silva, Gonçalves Natália (571B-0A4E-24ED); Sousa, Maria Lígia; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "A Novel Chlorophyll Derivative, 132-Hydroxy-Pheofarnesin A, from a Marine Cyanobacteria with Lipid Reducing Activity". Trabalho apresentado em XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products, 2019.
  5. Silva, Gonçalves Natália; Sousa, Maria Lígia; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "Isolation of a novel compound, 13(2)-hydroxypheofarnesin a, with lipid reducing activity". Trabalho apresentado em IV Meeting of Medicinal Biotechnology, 2019.
  6. "Isolation of novel compounds from marine cyanobacteria for obesity related co-morbidities". 2019.
    10.3389/conf.FMARS.2018.06.00090
  7. Silva, Natália; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "Isolation of novel compounds from marine cyanobacteria for obesity related co-morbidities". Trabalho apresentado em Frontiers Marine Science Conference Abstract: IMMR'18 | International Meeting on Marine Research, 2018.
Tese / Dissertação
  1. Silva, Gonçalves Natália. "Bioactivity screening of marine cyanobacteria for the isolation of novel compounds for obesity related co-morbidities". Mestrado, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2018. https://hdl.handle.net/10216/116852.

Propriedade Intelectual

Pedido provisório de patente
  1. 2019. "HYDROXYPHEOPHORBIDE COMPOUNDS, METHODS AND USES THEREOF".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/09/27 Anti-obesity activity of vitamin K family in zebrafish potentially involving different metabolic targets Blue Think Conference (BTC)
Interdisciplinary Centre of Marine and Environmental Research CIIMAR (Porto, Portugal)
2021/09/01 Validation of Bioactivity-based Molecular Networking for Anti-Obesity Natural Products Discovery XII European Conference on Marine Natural Products
(Galway, Irlanda)
2021/08/11 The potential of marine cyanobacteria as a source of lipid reducing metabolites 1st International Congress of Biotechnology and Bioengineering and the 5th Peruvian Congress Biotechnology and Bioengineering - COPEBIOT
(Peru)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2018/11 - 2018/11 Participation on the Blue and Green course. This course provided state-of-the-art lectures on important developments in the field of HTS: sample management, data analysis, phenotypic screening, target-based assays, whole small animal models, and secondary screenings (ADME, toxicity, pharmacokinetics).
Oficina (workshop)
High Throughput screening and Safety course
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
2018 - 2018 Participation on the Blue and Green advanced course. This course provided state-of-the-art lectures and hands-on-training on Discovery, Isolation and Structure Elucidation of Marine Natural Products.
Oficina (workshop)
Marine Natural Products: Discovery and Structure elucidation
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
Distinções

Outra distinção

2021 10 Best Poster Live Session