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Natália Gonçalves da Silva has a doctoral degree in Marine Biotechnology (2025) from the University of Porto, and is currently a Junior Researcher on the "CYANOMETAL" project at the Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), in the Blue Biotechnology, Environment and Health (BBEH) research team. Her current research investigation focuses on the study, isolation and structure elucidation of novel natural compounds from cyanobacteria for Alzheimer's disease. She already participated in several projects (European and National), either as a Research Fellow, Research Technician and Junior Researcher, published 4 papers in specialised peer-reviewed Journals, co-invented an international patent, and attended/participated in several international conferences. She has more than seven years of experience in the isolation and structural elucidation of bioactive compounds (natural products chemistry), microorganism cultures, omics approaches, bioactivity screening assays (in vitro and in vivo), and molecular characterisation of compounds in human pathologies.
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Identificação

Identificação pessoal

Nome completo
Natália Gonçalves da Silva

Nomes de citação

  • Silva, Gonçalves Natália

Identificadores de autor

Ciência ID
571B-0A4E-24ED
ORCID iD
0000-0002-2168-6027

Endereços de correio eletrónico

  • nsilva@ciimar.up.pt (Profissional)

Telefones

Telefone
  • 223401800 (Profissional)

Moradas

  • CIIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental. Terminal de Cruzeiros de Leixões, Av. General Norton de Matos s/n, 4450-208 M, Porto, Matosinhos, Portugal (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
  • Ciências Médicas e da Saúde - Biotecnologia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2020/10/01 - 2025/07
Concluído
 Biotecnologia Marinha e Aquacultura (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"The potential of cyanobacteria as a source of lipid-reducing metabolites: isolation, roles on lipid metabolism and metabolic targets" (TESE/DISSERTAÇÃO)
2016/09 - 2018/11
Concluído
 Toxicologia e Contaminação Ambientais (Mestrado integrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Bioactivity screening of marine cyanobacteria for the isolation of novel compounds for obesity related co-morbidities" (TESE/DISSERTAÇÃO)
 19
2013/09 - 2016/07
Concluído
 Ciências do Meio Aquático (Licenciatura)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2025/12/01 - Atual Investigador Contratado (Investigação) Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology, Environment and Health (BBEH), Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2025/02/01 - 2025/11/30 Investigador Contratado (Investigação) Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Biodiscovery for Health (B4H) group), Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2019/01/15 - 2020/07/31 Investigador (Investigação) Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/10/01 - 2025/06/26 PhD student: project focused on the potential of cyanobacteria as a source of lipid-reducing metabolites: isolation, roles on lipid metabolism and metabolic targets Universidade do Porto Faculdade de Ciências, Portugal
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Biodiscovery for Health (B4H) group), Portugal
(...)
2017/09/01 - 2018/11/12 Master's thesis student: project focused on natural compounds isolated from marine cyanobacteria towards obesity Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
2016/03/07 - 2016/06/17 Internship of initiation to scientific research entitled “Efeitos de contaminantes ambientais em organismos representativos de dois níveis tróficos de ecossistemas aquáticos: C. vulgaris e D. magna" Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal. Population Studies Department, Laboratory of Ecotoxicology, Stress ecology and Environmental Health, ICBAS., Portugal
Projetos

Projeto

Designação Financiadores
2025/12/01 - Atual CYANOMETAL- Discovery of cyanobacterial metal chelators: a multifunctional solution for Alzheimer’s disease
COMPETE2030-FEDER-00876800
Investigador Pós-doutorado
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology, Environment and Health (BBEH), Portugal
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Em curso
2019/01/15 - Atual CYANOBESITY - Cyanobacteria as a source of bioactive compounds with effects on obesity and obesity-related co-morbidities
ERA-MBT/0001/2015
Bolseiro de Investigação
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Em curso
2025/02/01 - 2025/11/30 Blue Bioeconomy Pact, WP5 ALGAE
C644915664-00000026
Investigador
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Biodiscovery for Health (B4H) group), Portugal
Concluído
2020/01/01 - 2024/12/31 Interdisciplinary Centre of Marine and Environmental Research
UIDB/04423/2020
10.54499/UIDB/04423/2020
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/01/01 - 2019/03/28 EPHEMARE - ECOTOXICICOLOGICAL EFFECTS OF MICROPLASTICS IN MARINE ECOSYSTEMS (JPIOCEANS/0004/2015)
JPIOCEANS/0004/2015
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Natália Gonçalves Silva; Marco Preto; Vitor Vasconcelos; Ralph Urbatzka. "Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism". Food & Function (2024): https://doi.org/10.1039/D3FO02915H.
    10.1039/D3FO02915H
  2. Tiago Ribeiro; Kristín Jónsdóttir; Rene Hernandez-Bautista; Natália Gonçalves Silva; Begoña Sánchez-Astráin; Afshin Samadi; Finnur F. Eiriksson; et al. "Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro Approaches". Marine Drugs (2023): https://doi.org/10.3390/md21090498.
    10.3390/md21090498
  3. Costa, Margarida; Rosa, Filipa; Ribeiro, Tiago; Hernandez-Bautista, Rene; Bonaldo, Marco; Gonçalves Silva, Natália; Eiríksson, Finnur; et al. "Identification of Cyanobacterial Strains with Potential for the Treatment of Obesity-Related Co-Morbidities by Bioactivity, Toxicity Evaluation and Metabolite Profiling". Marine Drugs 17 5 (2019): 280. http://dx.doi.org/10.3390/md17050280.
    Publicado • 10.3390/md17050280
  4. Freitas, Sara; Silva, Natália Gonçalves; Sousa, Maria Lígia; Ribeiro, Tiago; Rosa, Filipa; Leão, Pedro N.; Vasconcelos, Vitor; Reis, Mariana Alves; Urbatzka, Ralph. "Chlorophyll Derivatives from Marine Cyanobacteria with Lipid-Reducing Activities". Marine Drugs 17 4 (2019): 229-247. http://dx.doi.org/10.3390/md17040229.
    Publicado • 10.3390/md17040229
Poster em conferência
  1. Silva, Natália G.; Preto, Marco; Vasconcelos, Vítor; Urbatzka, Ralph. "The Role of Vitamin K Family in Obesity". Trabalho apresentado em 7th Iberian Congress on Cyanotoxins/3rd Iberoamerican Congress on Cyanotoxins, 2022.
    10.3390/blsf2022014036
  2. Silva, Gonçalves Natália; Preto, Marco; Vasconcelos, Vitor; Urbatzka, Ralph. "Uncovering the effects of the vitamins K family on lipid metabolism". Trabalho apresentado em Trends in Natural Products Research: A PSE Young Scientists’ Meeting (PSE-YSM2022), 2022.
  3. Silva, Gonçalves Natália; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "Validation of Bioactivity-based Molecular Networking for Anti-Obesity Natural Products Discovery". Trabalho apresentado em XII European Conference on Marine Natural Products, 2021.
  4. Silva, Gonçalves Natália (571B-0A4E-24ED); Sousa, Maria Lígia; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "A Novel Chlorophyll Derivative, 132-Hydroxy-Pheofarnesin A, from a Marine Cyanobacteria with Lipid Reducing Activity". Trabalho apresentado em XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products, 2019.
  5. Silva, Gonçalves Natália; Sousa, Maria Lígia; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "Isolation of a novel compound, 13(2)-hydroxypheofarnesin a, with lipid reducing activity". Trabalho apresentado em IV Meeting of Medicinal Biotechnology, 2019.
  6. "Isolation of novel compounds from marine cyanobacteria for obesity related co-morbidities". 2019.
    10.3389/conf.FMARS.2018.06.00090
  7. Silva, Natália; Reis, Mariana; Vasconcelos, Vitor; Urbatzka, Ralph. "Isolation of novel compounds from marine cyanobacteria for obesity related co-morbidities". Trabalho apresentado em Frontiers Marine Science Conference Abstract: IMMR'18 | International Meeting on Marine Research, 2018.
Tese / Dissertação
  1. Silva, Gonçalves Natália. "Bioactivity screening of marine cyanobacteria for the isolation of novel compounds for obesity related co-morbidities". Mestrado, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2018. https://hdl.handle.net/10216/116852.

Propriedade Intelectual

Pedido provisório de patente
  1. 2019. "HYDROXYPHEOPHORBIDE COMPOUNDS, METHODS AND USES THEREOF".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/06/20 Discovery of a bioactive vitamin K analogue in cyanobacteria: uncovering the roles of the vitamin K family on lipid metabolism International Society for Applied Phycology (ISAP)
(Porto, Portugal)
2022/09/27 Anti-obesity activity of vitamin K family in zebrafish potentially involving different metabolic targets Blue Think Conference (BTC)
Interdisciplinary Centre of Marine and Environmental Research CIIMAR (Porto, Portugal)
2021/09/01 Validation of Bioactivity-based Molecular Networking for Anti-Obesity Natural Products Discovery XII European Conference on Marine Natural Products
(Galway, Irlanda)
2021/08/11 The potential of marine cyanobacteria as a source of lipid reducing metabolites 1st International Congress of Biotechnology and Bioengineering and the 5th Peruvian Congress Biotechnology and Bioengineering - COPEBIOT
(Peru)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/11 - 2018/11 Participation on the Blue and Green course. This course provided state-of-the-art lectures on important developments in the field of HTS: sample management, data analysis, phenotypic screening, target-based assays, whole small animal models, and secondary screenings (ADME, toxicity, pharmacokinetics).
Oficina (workshop)
 High Throughput screening and Safety course
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
2018 - 2018 Participation on the Blue and Green advanced course. This course provided state-of-the-art lectures and hands-on-training on Discovery, Isolation and Structure Elucidation of Marine Natural Products.
Oficina (workshop)
 Marine Natural Products: Discovery and Structure elucidation
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Blue Biotechnology and Ecotoxicology - BBE Laboratory, Portugal
Distinções

Outra distinção

2021 10 Best Poster Live Session