Svilen Simeonov. Completed the Doutoramento in Química Farmacêutica e Terapêutica in 2014/10/24 by Universidade de Lisboa Faculdade de Farmácia and Mestrado in Organic Chemistry in 2004/03/03 by Sofiski Universitet Sv Kliment Ohridski. Is Researcher in Universidade de Lisboa Faculdade de Farmácia and simultaneously hold a position of assoc. prof. at the Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences. Published 32 articles in journals, above 1500 citations, h-index =14. Has 1 book(s). Organized 1 event(s). Co-supervised 1 MSc dissertation(s). Has received 1 award and/or honors. Participates and/or participated as Principal investigator in 1 project(s).

Identificação pessoal

Nome completo
Svilen Simeonov

Nomes de citação

  • Simeonov, Svilen

Identificadores de autor

Ciência ID


Idioma Conversação Leitura Escrita Compreensão Peer-review
Búlgaro (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Russo Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B2)
Grau Classificação
2010/08/01 - 2014/10/24
Química Farmacêutica e Terapêutica (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
" “New synthetic methodologies from biorenewable resources” " (TESE/DISSERTAÇÃO)
distinction and honours
2003/01/01 - 2004/03/03
Organic Chemistry (Mestrado)
Sofiski universitet Sv Kliment Ohridski, Bulgária
" “Synthesis, electron structure and spectra of 2-aryl-4-(3H)-quinazolinones”" (TESE/DISSERTAÇÃO)
Percurso profissional


Categoria Profissional
Instituição de acolhimento
2019/06/14 - Atual Investigador (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - Atual Investigador (Investigação) Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgária
2006 - 2010 Assistente de Investigação (carreira) (Investigação) Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgária


Designação Financiadores
2018/12 - Atual New approaches for lignocellulosic biomass utilization towards chemical products and materials for smart and green development
Investigador responsável
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgária
Fond Naucni izsledvania
Em curso
2019/04 - 2020/04 Innovative approaches for sustainable utilization of biomass wastes towards biorenewable building blocks for organic synthesis: research driven strengthening the cooperation of Balkan countries
Investigador responsável
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgária
UNESCO World Heritage Centre


Designação Financiadores
2015/09/30 - 2016/09/30 Novel biorefinery concept for the conversion of carbohydrates into valuable building blocks
Investigador responsável
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgária
Institut po Organitsna himia s tsentar po fitohimija Balgarska akademija na naukite


Designação Financiadores
2021/01 - Atual Straightening training, research and innovation capacities in the valorization of bio-renewable resource
Universidade do Algarve Faculdade de Ciências e Tecnologia
Em curso


Artigo em revista
  1. Ravasco, J.M.J.M.; Monteiro, C.M.; Siopa, F.; Trindade, A.F.; Oble, J.; Poli, G.; Simeonov, S.P.; Afonso, C.A.M.. "Creating Diversity from Biomass: A Tandem Bio/Metal-Catalysis towards Chemoselective Synthesis of Densely Substituted Furans". ChemSusChem 12 20 (2019): 4629-4635. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073622064&partnerID=MN8TOARS.
  2. Simeonov, S.P.; Ravutsov, M.A.; Mihovilovic, M.D.. "Biorefinery via Achmatowicz Rearrangement: Synthesis of Pentane-1,2,5-triol from Furfuryl Alcohol". ChemSusChem 12 12 (2019): 2748-2754. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067393489&partnerID=MN8TOARS.
  3. Pardo Cuervo, O.H.; Simeonov, S.P.; Peixoto, A.F.; Popova, M.D.; Lazarova, H.I.; Romanelli, G.P.; Martínez, J.J.; Freire, C.; Afonso, C.A.M.. "Efficient Continuous Production of the Biofuel Additive 5-(t-Butoxymethyl) Furfural from 5-Hydroxymethylfurfural". Energy Technology 7 11 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071309019&partnerID=MN8TOARS.
  4. Simeonov, S.P.; Lazarova, H.I.; Marinova, M.K.; Popova, M.D.. "Achmatowicz rearrangement enables hydrogenolysis-free gas-phase synthesis of pentane-1,2,5-triol from furfuryl alcohol". Green Chemistry 21 20 (2019): 5657-5664. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074223376&partnerID=MN8TOARS.
  5. Simeonov, S.P.; Simova, S.D.; Shivachev, B.L.; Nikolova, R.P.; Kurteva, V.B.. "Solution and solid state characterization of “sparteine surrogate” (+)-(1R,5S,11aS)-tetrahydrodeoxocytisine". Bulgarian Chemical Communications 49 (2019): 103-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074523756&partnerID=MN8TOARS.
  6. Gomes, R.F.A.; Mitrev, Y.N.; Simeonov, S.P.; Afonso, C.A.M.. "Going Beyond the Limits of the Biorenewable Platform: Sodium Dithionite-Promoted Stabilization of 5-Hydroxymethylfurfural". ChemSusChem 11 10 (2018): 1612-1616. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045713145&partnerID=MN8TOARS.
  7. Candeias, N.R.; Assoah, B.; Simeonov, S.P.. "Production and Synthetic Modifications of Shikimic Acid". Chemical Reviews 118 20 (2018): 10458-10550. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054984036&partnerID=MN8TOARS.
  8. Stanev, N.; Bordado, J.C.M.; Afonso, C.A.M.; Simeonov, S.P.. "Solvent-Free Catalytic Self-Etherification of 5-Hydroxymethyl Furfural". ChemCatChem 10 23 (2018): 5406-5409. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056780196&partnerID=MN8TOARS.
  9. Cavaca, L.A.S.; Rodrigues, C.A.B.; Simeonov, S.P.; Gomes, R.F.A.; Coelho, J.A.S.; Romanelli, G.P.; Sathicq, A.G.; Martínez, J.J.; Afonso, C.A.M.. "Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis". ChemSusChem 11 14 (2018): 2300-2305. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050403119&partnerID=MN8TOARS.
  10. Gawali, V.S.; Simeonov, S.; Drescher, M.; Knott, T.; Scheel, O.; Kudolo, J.; Kählig, H.; et al. "C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers". ChemMedChem 12 22 (2017): 1819-1822. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032897529&partnerID=MN8TOARS.
  11. Ravasco, J.M.J.M.; Coelho, J.A.S.; Simeonov, S.P.; Afonso, C.A.M.. "Bifunctional Cr3+ modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose". RSC Advances 7 13 (2017): 7555-7559. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010657868&partnerID=MN8TOARS.
  12. Vicente, A.I.; Coelho, J.A.S.; Simeonov, S.P.; Lazarova, H.I.; Popova, M.D.; Afonso, C.A.M.. "Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF)". Molecules 22 2 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013631909&partnerID=MN8TOARS.
  13. Simeonov, S.P.; Nunes, J.P.M.; Guerra, K.; Kurteva, V.B.; Afonso, C.A.M.. "Synthesis of Chiral Cyclopentenones". Chemical Reviews 116 10 (2016): 5744-5893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973325117&partnerID=MN8TOARS.
  14. Simeonov, S.P.; Afonso, C.A.M.. "Basicity and stability of urea deep eutectic mixtures". RSC Advances 6 7 (2016): 5485-5490. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955607019&partnerID=MN8TOARS.
  15. Antonov, L.; Deneva, V.; Simeonov, S.; Kurteva, V.; Crochet, A.; Fromm, K.M.; Shivachev, B.; et al. "Controlled tautomeric switching in azonaphthols tuned by substituents on the phenyl ring". ChemPhysChem 16 3 (2015): 649-657. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027924918&partnerID=MN8TOARS.
  16. Frade, R.F.M.; Coelho, J.A.S.; Simeonov, S.P.; Afonso, C.A.M.. "An emerging platform from renewable resources: Selection guidelines for human exposure of furfural-related compounds". Toxicology Research 3 5 (2014): 311-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905668027&partnerID=MN8TOARS.
  17. Martins, A.N.C.; Simeonov, S.P.; Frija, L.M.T.; Viveiros, R.; Lourenço, A.; Silva, M.S.D.; Casimiro, T.; Afonso, C.A.M.. "Isolation, analytical quantification and seasonal variation of labdanolic acid from the Portuguese-grown Cistus ladaniferus". Industrial Crops and Products 60 (2014): 226-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903832657&partnerID=MN8TOARS.
  18. De Pedro, I.; García-Saiz, A.; González, J.; Ruiz De Larramendi, I.; Rojo, T.; Afonso, C.A.M.; Simeonov, S.P.; et al. "Magnetic ionic plastic crystal: Choline[FeCl4]". Physical Chemistry Chemical Physics 15 30 (2013): 12724-12733. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881128971&partnerID=MN8TOARS.
  19. Frade, R.F.M.; Simeonov, S.; Rosatella, A.A.; Siopa, F.; Afonso, C.A.M.. "Toxicological evaluation of magnetic ionic liquids in human cell lines". Chemosphere 92 1 (2013): 100-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876988633&partnerID=MN8TOARS.
  20. Simeonov, S.P.; Coelho, J.A.S.; Afonso, C.A.M.. "Integrated chemo-enzymatic production of 5-hydroxymethylfurfural from glucose". ChemSusChem 6 6 (2013): 997-1000. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878622602&partnerID=MN8TOARS.
  21. Subbiah, S.; Simeonov, S.P.; Esperança, J.M.S.S.; Rebelo, L.P.N.; Afonso, C.A.M.. "Direct transformation of 5-hydroxymethylfurfural to the building blocks 2,5-dihydroxymethylfurfural (DHMF) and 5-hydroxymethyl furanoic acid (HMFA) via Cannizzaro reaction". Green Chemistry 15 10 (2013): 2849-2853. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884656983&partnerID=MN8TOARS.
  22. Simeonov, S.P.; Afonso, C.A.M.. "Batch and flow synthesis of 5-hydroxymethylfurfural (HMF) from fructose as a bioplatform intermediate: An experiment for the organic or analytical laboratory". Journal of Chemical Education 90 10 (2013): 1373-1375. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885396683&partnerID=MN8TOARS.
  23. Ahmedova, A.; Simeonov, S.P.; Kurteva, V.B.; Antonov, L.. "Tautomerism of 4,4'-dihydroxy-1,1'-naphthaldazine studied by experimental and theoretical methods". Chemistry Central Journal 7 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873504235&partnerID=MN8TOARS.
  24. Zakrzewska, M.E.; Rosatella, A.A.; Simeonov, S.P.; Afonso, C.A.M.; Najdanovic-Visak, V.; Nunes da Ponte, M.. "Solubility of carbon dioxide in ammonium based CO2-induced ionic liquids". Fluid Phase Equilibria 354 (2013): 19-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880181846&partnerID=MN8TOARS.
  25. Albo, J.; Santos, E.; Neves, L.A.; Simeonov, S.P.; Afonso, C.A.M.; Crespo, J.G.; Irabien, A.. "Separation performance of CO 2 through Supported Magnetic Ionic Liquid Membranes (SMILMs)". Separation and Purification Technology 97 (2012): 26-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866089930&partnerID=MN8TOARS.
  26. Simeonov, S.P.; Coelho, J.A.S.; Afonso, C.A.M.. "An integrated approach for the production and isolation of 5-hydroxymethylfurfural from carbohydrates". ChemSusChem 5 8 (2012): 1388-1391. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864699780&partnerID=MN8TOARS.
  27. Rosatella, A.A.; Simeonov, S.P.; Frade, R.F.M.; Afonso, C.A.M.. "5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications". Green Chemistry 13 4 (2011): 754-793. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953778895&partnerID=MN8TOARS.
  28. Simeonov, Svilen. "Symmetrical acyclic aryl aldazines with antibacterial and antifungal activity". Pharmacology & Pharmacy (2010):
  29. Antonov, L.M.; Kurteva, V.B.; Simeonov, S.P.; Deneva, V.V.; Crochet, A.; Fromm, K.M.. "Tautocrowns: a concept for a sensing molecule with an active side-arm". Tetrahedron 66 24 (2010): 4292-4297. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953134691&partnerID=MN8TOARS.
  30. Simeonov, Svilen. "Enantioresolution of a Series of Chiral Benzyl Alcohols by HPLC on a Dinitrobenzoylphenylglycine Stationary Phase after Achiral Pre-column Derivatization". American Journal of Analytical Chemistry (2010):
    DOI: 10.4236/ajac.2010.11001
  31. Antonov, L.; Deneva, V.; Simeonov, S.; Kurteva, V.; Nedeltcheva, D.; Wirz, J.. "Exploiting tautomerism for switching and signaling". Angewandte Chemie - International Edition 48 42 (2009): 7875-7878. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349686952&partnerID=MN8TOARS.
  32. Simeonov, S.P.; Kurteva, V.B.; Bontchev, R.P.. "One-pot solvent-free synthesis of symmetrical azines under microwave irradiation". Bulgarian Chemical Communications 40 4 (2008): 409-417. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954156660&partnerID=MN8TOARS.
  1. Simeonov, S.P.; Coelho, J.A.S.; Afonso, C.A.M.. Synthesis of 5-(Hydroxymethyl)furfural (HMF). 2016.

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2015/08/10 Scalable Synthetic Methodologies for the Conversion of Carbohydrates to 5(Hydroxymethyl)furfural (HMF) IUPAC World Chemistry Congress
(Busan, Coreia do Sul)


Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2014 - 2014 Extracção Selectiva do Ácido Labdanólico de Extracto Natural Utilizando Polímeros Molecularmente Impressos
Universidade de Lisboa Faculdade de Farmácia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2013/09/04 - 2013/09/06 10º ENCONTRO NACIONAL DE QUÍMICA ORGÂNICA, 10ENQO (2013/09/04 - 2013/09/06)
Conferência (Membro da Comissão Organizadora)
Universidade de Lisboa Faculdade de Farmácia, Portugal


2015 Green Chemistry for Life award for young scientists