Svilen Simeonov. Completed the Doutoramento in Química Farmacêutica e Terapêutica in 2014/10/24 by Universidade de Lisboa Faculdade de Farmácia and Mestrado in Organic Chemistry in 2004/03/03 by Sofiski Universitet Sv Kliment Ohridski. Is Researcher in Universidade de Lisboa Faculdade de Farmácia and simultaneously hold a position of assoc. prof. at the Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences. Published 32 articles in journals, above 1500 citations, h-index =14. Has 1 book(s). Organized 1 event(s). Co-supervised 1 MSc dissertation(s). Has received 1 award and/or honors. Participates and/or participated as Principal investigator in 1 project(s).

Personal identification

Full name
Svilen Simeonov

Citation names

  • Simeonov, Svilen

Author identifiers

Ciência ID


Language Speaking Reading Writing Listening Peer-review
Bulgarian (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Russian Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2)
Degree Classification
2010/08/01 - 2014/10/24
Química Farmacêutica e Terapêutica (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
" “New synthetic methodologies from biorenewable resources” " (THESIS/DISSERTATION)
distinction and honours
2003/01/01 - 2004/03/03
Organic Chemistry (Mestrado)
Sofiski universitet Sv Kliment Ohridski, Bulgaria
" “Synthesis, electron structure and spectra of 2-aryl-4-(3H)-quinazolinones”" (THESIS/DISSERTATION)


Host institution
2019/06/14 - Current Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - Current Researcher (Research) Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgaria
2006 - 2010 Research Assistant (Research) Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgaria


Designation Funders
2018/12 - Current New approaches for lignocellulosic biomass utilization towards chemical products and materials for smart and green development
Principal investigator
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgaria
Fond Naucni izsledvania
2019/04 - 2020/04 Innovative approaches for sustainable utilization of biomass wastes towards biorenewable building blocks for organic synthesis: research driven strengthening the cooperation of Balkan countries
Principal investigator
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgaria
UNESCO World Heritage Centre


Designation Funders
2015/09/30 - 2016/09/30 Novel biorefinery concept for the conversion of carbohydrates into valuable building blocks
Principal investigator
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciencies, Bulgaria
Institut po Organitsna himia s tsentar po fitohimija Balgarska akademija na naukite


Designation Funders
2021/01 - Current Straightening training, research and innovation capacities in the valorization of bio-renewable resource
Universidade do Algarve Faculdade de Ciências e Tecnologia


  1. Simeonov, S.P.; Coelho, J.A.S.; Afonso, C.A.M.. Synthesis of 5-(Hydroxymethyl)furfural (HMF). 2016.
Journal article
  1. Ravasco, J.M.J.M.; Monteiro, C.M.; Siopa, F.; Trindade, A.F.; Oble, J.; Poli, G.; Simeonov, S.P.; Afonso, C.A.M.. "Creating Diversity from Biomass: A Tandem Bio/Metal-Catalysis towards Chemoselective Synthesis of Densely Substituted Furans". ChemSusChem 12 20 (2019): 4629-4635. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073622064&partnerID=MN8TOARS.
  2. Simeonov, S.P.; Ravutsov, M.A.; Mihovilovic, M.D.. "Biorefinery via Achmatowicz Rearrangement: Synthesis of Pentane-1,2,5-triol from Furfuryl Alcohol". ChemSusChem 12 12 (2019): 2748-2754. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067393489&partnerID=MN8TOARS.
  3. Pardo Cuervo, O.H.; Simeonov, S.P.; Peixoto, A.F.; Popova, M.D.; Lazarova, H.I.; Romanelli, G.P.; Martínez, J.J.; Freire, C.; Afonso, C.A.M.. "Efficient Continuous Production of the Biofuel Additive 5-(t-Butoxymethyl) Furfural from 5-Hydroxymethylfurfural". Energy Technology 7 11 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071309019&partnerID=MN8TOARS.
  4. Simeonov, S.P.; Lazarova, H.I.; Marinova, M.K.; Popova, M.D.. "Achmatowicz rearrangement enables hydrogenolysis-free gas-phase synthesis of pentane-1,2,5-triol from furfuryl alcohol". Green Chemistry 21 20 (2019): 5657-5664. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074223376&partnerID=MN8TOARS.
  5. Simeonov, S.P.; Simova, S.D.; Shivachev, B.L.; Nikolova, R.P.; Kurteva, V.B.. "Solution and solid state characterization of “sparteine surrogate” (+)-(1R,5S,11aS)-tetrahydrodeoxocytisine". Bulgarian Chemical Communications 49 (2019): 103-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074523756&partnerID=MN8TOARS.
  6. Gomes, R.F.A.; Mitrev, Y.N.; Simeonov, S.P.; Afonso, C.A.M.. "Going Beyond the Limits of the Biorenewable Platform: Sodium Dithionite-Promoted Stabilization of 5-Hydroxymethylfurfural". ChemSusChem 11 10 (2018): 1612-1616. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045713145&partnerID=MN8TOARS.
  7. Candeias, N.R.; Assoah, B.; Simeonov, S.P.. "Production and Synthetic Modifications of Shikimic Acid". Chemical Reviews 118 20 (2018): 10458-10550. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054984036&partnerID=MN8TOARS.
  8. Stanev, N.; Bordado, J.C.M.; Afonso, C.A.M.; Simeonov, S.P.. "Solvent-Free Catalytic Self-Etherification of 5-Hydroxymethyl Furfural". ChemCatChem 10 23 (2018): 5406-5409. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056780196&partnerID=MN8TOARS.
  9. Cavaca, L.A.S.; Rodrigues, C.A.B.; Simeonov, S.P.; Gomes, R.F.A.; Coelho, J.A.S.; Romanelli, G.P.; Sathicq, A.G.; Martínez, J.J.; Afonso, C.A.M.. "Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis". ChemSusChem 11 14 (2018): 2300-2305. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050403119&partnerID=MN8TOARS.
  10. Gawali, V.S.; Simeonov, S.; Drescher, M.; Knott, T.; Scheel, O.; Kudolo, J.; Kählig, H.; et al. "C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers". ChemMedChem 12 22 (2017): 1819-1822. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032897529&partnerID=MN8TOARS.
  11. Ravasco, J.M.J.M.; Coelho, J.A.S.; Simeonov, S.P.; Afonso, C.A.M.. "Bifunctional Cr3+ modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose". RSC Advances 7 13 (2017): 7555-7559. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010657868&partnerID=MN8TOARS.
  12. Vicente, A.I.; Coelho, J.A.S.; Simeonov, S.P.; Lazarova, H.I.; Popova, M.D.; Afonso, C.A.M.. "Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF)". Molecules 22 2 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013631909&partnerID=MN8TOARS.
  13. Simeonov, S.P.; Nunes, J.P.M.; Guerra, K.; Kurteva, V.B.; Afonso, C.A.M.. "Synthesis of Chiral Cyclopentenones". Chemical Reviews 116 10 (2016): 5744-5893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973325117&partnerID=MN8TOARS.
  14. Simeonov, S.P.; Afonso, C.A.M.. "Basicity and stability of urea deep eutectic mixtures". RSC Advances 6 7 (2016): 5485-5490. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955607019&partnerID=MN8TOARS.
  15. Antonov, L.; Deneva, V.; Simeonov, S.; Kurteva, V.; Crochet, A.; Fromm, K.M.; Shivachev, B.; et al. "Controlled tautomeric switching in azonaphthols tuned by substituents on the phenyl ring". ChemPhysChem 16 3 (2015): 649-657. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027924918&partnerID=MN8TOARS.
  16. Frade, R.F.M.; Coelho, J.A.S.; Simeonov, S.P.; Afonso, C.A.M.. "An emerging platform from renewable resources: Selection guidelines for human exposure of furfural-related compounds". Toxicology Research 3 5 (2014): 311-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905668027&partnerID=MN8TOARS.
  17. Martins, A.N.C.; Simeonov, S.P.; Frija, L.M.T.; Viveiros, R.; Lourenço, A.; Silva, M.S.D.; Casimiro, T.; Afonso, C.A.M.. "Isolation, analytical quantification and seasonal variation of labdanolic acid from the Portuguese-grown Cistus ladaniferus". Industrial Crops and Products 60 (2014): 226-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903832657&partnerID=MN8TOARS.
  18. De Pedro, I.; García-Saiz, A.; González, J.; Ruiz De Larramendi, I.; Rojo, T.; Afonso, C.A.M.; Simeonov, S.P.; et al. "Magnetic ionic plastic crystal: Choline[FeCl4]". Physical Chemistry Chemical Physics 15 30 (2013): 12724-12733. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881128971&partnerID=MN8TOARS.
  19. Frade, R.F.M.; Simeonov, S.; Rosatella, A.A.; Siopa, F.; Afonso, C.A.M.. "Toxicological evaluation of magnetic ionic liquids in human cell lines". Chemosphere 92 1 (2013): 100-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876988633&partnerID=MN8TOARS.
  20. Simeonov, S.P.; Coelho, J.A.S.; Afonso, C.A.M.. "Integrated chemo-enzymatic production of 5-hydroxymethylfurfural from glucose". ChemSusChem 6 6 (2013): 997-1000. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878622602&partnerID=MN8TOARS.
  21. Subbiah, S.; Simeonov, S.P.; Esperança, J.M.S.S.; Rebelo, L.P.N.; Afonso, C.A.M.. "Direct transformation of 5-hydroxymethylfurfural to the building blocks 2,5-dihydroxymethylfurfural (DHMF) and 5-hydroxymethyl furanoic acid (HMFA) via Cannizzaro reaction". Green Chemistry 15 10 (2013): 2849-2853. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884656983&partnerID=MN8TOARS.
  22. Simeonov, S.P.; Afonso, C.A.M.. "Batch and flow synthesis of 5-hydroxymethylfurfural (HMF) from fructose as a bioplatform intermediate: An experiment for the organic or analytical laboratory". Journal of Chemical Education 90 10 (2013): 1373-1375. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885396683&partnerID=MN8TOARS.
  23. Ahmedova, A.; Simeonov, S.P.; Kurteva, V.B.; Antonov, L.. "Tautomerism of 4,4'-dihydroxy-1,1'-naphthaldazine studied by experimental and theoretical methods". Chemistry Central Journal 7 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873504235&partnerID=MN8TOARS.
  24. Zakrzewska, M.E.; Rosatella, A.A.; Simeonov, S.P.; Afonso, C.A.M.; Najdanovic-Visak, V.; Nunes da Ponte, M.. "Solubility of carbon dioxide in ammonium based CO2-induced ionic liquids". Fluid Phase Equilibria 354 (2013): 19-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880181846&partnerID=MN8TOARS.
  25. Albo, J.; Santos, E.; Neves, L.A.; Simeonov, S.P.; Afonso, C.A.M.; Crespo, J.G.; Irabien, A.. "Separation performance of CO 2 through Supported Magnetic Ionic Liquid Membranes (SMILMs)". Separation and Purification Technology 97 (2012): 26-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866089930&partnerID=MN8TOARS.
  26. Simeonov, S.P.; Coelho, J.A.S.; Afonso, C.A.M.. "An integrated approach for the production and isolation of 5-hydroxymethylfurfural from carbohydrates". ChemSusChem 5 8 (2012): 1388-1391. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864699780&partnerID=MN8TOARS.
  27. Rosatella, A.A.; Simeonov, S.P.; Frade, R.F.M.; Afonso, C.A.M.. "5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications". Green Chemistry 13 4 (2011): 754-793. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953778895&partnerID=MN8TOARS.
  28. Simeonov, Svilen. "Symmetrical acyclic aryl aldazines with antibacterial and antifungal activity". Pharmacology & Pharmacy (2010):
  29. Antonov, L.M.; Kurteva, V.B.; Simeonov, S.P.; Deneva, V.V.; Crochet, A.; Fromm, K.M.. "Tautocrowns: a concept for a sensing molecule with an active side-arm". Tetrahedron 66 24 (2010): 4292-4297. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953134691&partnerID=MN8TOARS.
  30. Simeonov, Svilen. "Enantioresolution of a Series of Chiral Benzyl Alcohols by HPLC on a Dinitrobenzoylphenylglycine Stationary Phase after Achiral Pre-column Derivatization". American Journal of Analytical Chemistry (2010):
    DOI: 10.4236/ajac.2010.11001
  31. Antonov, L.; Deneva, V.; Simeonov, S.; Kurteva, V.; Nedeltcheva, D.; Wirz, J.. "Exploiting tautomerism for switching and signaling". Angewandte Chemie - International Edition 48 42 (2009): 7875-7878. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349686952&partnerID=MN8TOARS.
  32. Simeonov, S.P.; Kurteva, V.B.; Bontchev, R.P.. "One-pot solvent-free synthesis of symmetrical azines under microwave irradiation". Bulgarian Chemical Communications 40 4 (2008): 409-417. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954156660&partnerID=MN8TOARS.

Oral presentation

Presentation title Event name
Host (Event location)
2015/08/10 Scalable Synthetic Methodologies for the Conversion of Carbohydrates to 5(Hydroxymethyl)furfural (HMF) IUPAC World Chemistry Congress
(Busan, South Korea)


Thesis Title
Degree Subject (Type)
Institution / Organization
2014 - 2014 Extracção Selectiva do Ácido Labdanólico de Extracto Natural Utilizando Polímeros Molecularmente Impressos
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2013/09/04 - 2013/09/06 10º ENCONTRO NACIONAL DE QUÍMICA ORGÂNICA, 10ENQO (2013/09/04 - 2013/09/06)
Conference (Member of the Organising Committee)
Universidade de Lisboa Faculdade de Farmácia, Portugal


2015 Green Chemistry for Life award for young scientists