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Daniela S. C. Bispo is currently a PhD student of the Biotechnology Doctoral Program (specialization in Medical Biotechnology) at University of Aveiro. Under the supervision of Mariana B. Oliveira, João F. Mano and Ana M. Gil, she is characterizing the osteogenic differentiation of human stem cells through Nuclear Magnetic Resonance (NMR) metabolomics, work developed within the scope of the BIOIMPLANT project (A Metabolomics-guided Bioreactor for Improved Engineered Bone Implants, PTDC/BTM-ORG/28835/2017) and the BetterBone project (Metabolite-activated 3D stem cell differentiation into bone, 2022.04286.PTDC). Prior to her PhD, Daniela had a research fellow position in the BIOIMPLANT project, as well as in the ATLAS project (Bioengineered Autonomous Cell-biomaterials Devices for Generating Humanised Micro-tissues for Regenerative Medicine, ERC-2014-AdG-669858). Her academic background includes a master's degree in Biochemistry (specialization in Clinical Biochemistry) (2018) and a bachelor's degree in Biotechnology (2016), both at University of Aveiro.
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Identificação

Identificação pessoal

Nome completo
Daniela Sofia Cabedal Bispo

Nomes de citação

  • Bispo, Daniela S. C.
  • Bispo, Daniela
  • Daniela S. C. Bispo
  • Daniela Bispo

Identificadores de autor

Ciência ID
3216-1DC4-59EE
ORCID iD
0000-0002-5813-5421

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês
Português (Idioma materno)
Formação
Grau Classificação
2020 - 2024
Em curso
 Biotecnologia (Doutoramento)
Universidade de Aveiro, Portugal
2023/10 - 2023/12
Concluído
 Visiting student (Outros)
University of Glasgow, Reino Unido

Centre for the Cellular Microenvironment (CeMi), Reino Unido
2023/06/19 - 2023/06/23
Concluído
 XV International "Manuel Rico" NMR School (Summer School) (Outros)
SPANISH ROYAL SOCIETY OF CHEMISTRY (RSEQ), Espanha
 N.A.
2016/09/09 - 2018/11/15
Concluído
 Bioquímica (Mestrado)
Especialização em Bioquímica clínica
Universidade de Aveiro, Portugal
"Estudo da Heterogeneidade do Cancro da Mama: Metabolómica de um Modelo Murino" (TESE/DISSERTAÇÃO)
 18.0
2018/09/05 - 2018/09/14
Concluído
 Summer School in Computational Biology - direct contact learning activities (Summer School) (Outros)
Universidade de Coimbra, Portugal
 N.A.
2013/09/10 - 2016/07/20
Concluído
 Biotecnologia (Licenciatura)
Universidade de Aveiro, Portugal
"Preparação de nano-sistemas com polissacarídeos provenientes de macroalgas para aplicações biomédicas" (TESE/DISSERTAÇÃO)
 16.0
2010/09 - 2013/08/07
Concluído
 Curso Científico-Humanístico de Ciências e Tecnologias (Ensino secundário)
Escola Secundária de Ponte de Sor, Portugal
 18
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/02/13 - 2020/08 Bolseira de investigação (mestre) Universidade de Aveiro, Portugal
Universidade de Aveiro, Portugal
2019/01/21 - 2020/01/20 Bolseira de Investigação (mestre) Universidade de Aveiro, Portugal
Projetos

Bolsa

Designação Financiadores
2020/02/13 - 2020/07/01 ATLAS: Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine
669858
Bolseiro de Mestrado
Universidade de Aveiro, Portugal

Aveiro Institute of Materials (CICECO), Portugal
European Commission
Em curso

Projeto

Designação Financiadores
2023/02/20 - 2026/02/19 Metabolite-activated 3D stem cell differentiation into bone
2022.04286.PTDC
10.54499/2022.04286.PTDC
Membro da equipa
Universidade de Aveiro, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/02 - 2022/07/01 A metabolomics-guided bioreactor for improved engineered bone implants (BIOIMPLANT)
PTDC/BTM-ORG/28835/2017
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Bispo, Daniela S. C.; Correia, Marlene; Carneiro, Tatiana J.; Martins, Ana S. ; Reis, Aliana A. N.; Carvalho, Ana L. M. Batista de; Marques, Maria P. M.; Gil, Ana M.. "Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells". International Journal of Molecular Sciences 24 24 (2023): 17556. http://dx.doi.org/10.3390/ijms242417556.
    10.3390/ijms242417556
  2. Rodrigues, João A.; Bispo, Daniela S. C. (shared first authorship); Silva, Mónica G.; Araújo, Rita; Soares, Amadeu M. V. M.; Freitas, Rosa; Gil, Ana M.. "Impact of Sea Warming and 17-a-Ethinylestradiol Exposure on the Lipid Metabolism of Ruditapes philippinarum Clams". International Journal of Molecular Sciences 24 11 (2023): 9485. http://dx.doi.org/10.3390/ijms24119485.
    Publicado • 10.3390/ijms24119485
  3. Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Romek, Katarzyna; Marques, Inês M. C.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "An Intracellular Metabolic Signature as a Potential Donor-Independent Marker of the Osteogenic Differentiation of Adipose Tissue Mesenchymal Stem Cells". Cells 11 23 (2022): 3745. https://www.mdpi.com/2073-4409/11/23/3745.
    Acesso aberto • Publicado
  4. Bispo, Daniela S. C.; Lenka Michálková; Correia, Marlene; Jesus, Catarina S. H.; Duarte, Iola F; Brian J. Goodfellow; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation". Cells 11 8 (2022): 1257. https://www.mdpi.com/2073-4409/11/8/1257.
    Acesso aberto • Publicado • 10.3390/cells11081257
  5. Daniela S. C. Bispo; Catarina S. H. Jesus; Marlene Correia; Filipa Ferreira; Giulia Bonifazio; Brian J. Goodfellow; Mariana B. Oliveira; João F. Mano; Ana M. Gil. "NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells". Journal of Proteome Research 21 3 (2022): 654-670. https://doi.org/10.1021/acs.jproteome.1c00832.
    Publicado • 10.1021/acs.jproteome.1c00832
  6. Bispo, Daniela S. C.; Jesus, Catarina S. H.; Marques, Inês M. C.; Romek, Katarzyna M.; Oliveira, Mariana B.; Mano, João F.; Gil, Ana M.. "Metabolomic Applications in Stem Cell Research: a Review". Stem Cell Reviews and Reports 17 6 (2021): 2003-2024. http://dx.doi.org/10.1007/s12015-021-10193-z.
    10.1007/s12015-021-10193-z
  7. Bispo, Daniela; Fabris, Victoria; Lamb, Caroline A.; Lanari, Claudia; Helguero, Luisa A.; Gil, Ana M.. "Hormone-Independent Mouse Mammary Adenocarcinomas with Different Metastatic Potential Exhibit Different Metabolic Signatures". Biomolecules 10 9 (2020): 1242. http://dx.doi.org/10.3390/biom10091242.
    10.3390/biom10091242
  8. Araújo, Rita; Bispo, Daniela; Helguero, Luisa A.; Gil, Ana M.. "Metabolomic studies of breast cancer in murine models: A review". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 5 (2020): 165713. http://dx.doi.org/10.1016/j.bbadis.2020.165713.
    Publicado • 10.1016/j.bbadis.2020.165713
  9. Pinto, Ricardo J. B.; Bispo, Daniela; Vilela, Carla; Botas, Alexandre M. P.; Ferreira, Rute A. S.; Menezes, Ana C.; Campos, Fábio; et al. "One-Minute Synthesis of Size-Controlled Fucoidan-Gold Nanosystems: Antitumoral Activity and Dark Field Imaging". Materials 13 5 (2020): 1076. http://dx.doi.org/10.3390/ma13051076.
    Acesso aberto • Publicado • 10.3390/ma13051076
Poster em conferência
  1. Bispo, Daniela S. C.; João A. Rodrigues; Graça, Inês; Jesus, Catarina S. H.; Correia, Marlene C.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Non-invasive Detection of Universal Osteodifferentiation Signatures through Untargeted NMR Exometabolomics". Trabalho apresentado em Ciência 2024, 2024.
  2. Daniela S. C. Bispo; Joao E.A. Rodrigues; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Unveiling mesenchymal stem cells osteodifferentiation patterns across donors with NMR metabolomics". Trabalho apresentado em 4th Meeting of Young Biophysicists - Biophysics Festival, 2024.
  3. Daniela S. C. Bispo; Correia, Marlene; Henriques de Jesus, Catarina Sofia; Oliveira, Mariana B.; Rodrigues, Joao E.A.; Mano, Joao F.; Gil, Ana M.. "Non-invasive monitoring of mesenchymal stem cells osteodifferentiation by untargeted NMR Exometabolomics". Trabalho apresentado em Jornadas CICECO 23, 2023.
  4. Correia, Marlene; Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Rodrigues, Joao E.A.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Unveiling early predictive markers of mesenchymal stem cells osteogenesis capacity through NMR metabolomics". Trabalho apresentado em Jornadas CICECO 23, 2023.
  5. Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Correia, Marlene; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Search for donor-independent endometabolome markers of proliferating and osteodifferentiating mesenchymal stem cells". Trabalho apresentado em Jornadas CICECO - Universidade de Aveiro, 2022.
  6. Correia, Marlene; Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Exometabolome variations during osteogenic differentiation: Donor-independent markers". Trabalho apresentado em Jornadas CICECO - Universidade de Aveiro, 2022.
  7. Jesus, Catarina S. H.; Bispo, Daniela S. C.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Lipid Metabolic Adaptations to Mesenchymal Stem Cells Osteogenesis and Aging by 1H NMR Metabolomics". Trabalho apresentado em 8th International Iberian Biophysics Congress (IIBC2022), 2022.
  8. Bispo, Daniela S. C.. "Endo- and exometabolome adaptations during osteogenic differentiation of adipose-derived mesenchymal stem cells". Trabalho apresentado em BIOPHYSICS FESTIVAL – 2nd Meeting of Young Biophysicists, 2022.
  9. Correia, Marlene; Bispo, Daniela S. C.; Catarina S. H. Jesus; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Stem cell footprinting during osteogenic differentiation". Trabalho apresentado em BIOPHYSICS FESTIVAL - 2nd Meeting of Young Biophysicists, 2022.
  10. Jesus, Catarina S. H.; Bispo, Daniela S. C.; Marlene Correia; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Characterization of lipidic markers of osteogenic differentiation of mesenchymal stem cells using 1h nmr metabolomics". Trabalho apresentado em BIOPHYSICS FESTIVAL - 2nd Meeting of Young Biophysicists, 2022.
  11. Bispo, Daniela S. C.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Osteogenic differentiation of human adipose-derived stem cells followed by NMR metabolomics". Trabalho apresentado em Jornadas CICECO 2021, 2021.
  12. Bispo, Daniela S. C.; Jesus, Catarina S. H.; Lenka Michálková; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Metabolic markers of osteogenic differentiation of human adipose-derived stem cells through NMR metabolomics". Trabalho apresentado em EUROMAR, A European Magnetic Resonance Meeting, 2021.
  13. Bispo, Daniela; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Monitoring osteogenic differentiation with nuclear magnetic resonance (NMR)-based metabolomics". Trabalho apresentado em 9th Ibero-American NMR Meeting, 10th GERMN Biennial Meeting and the 7th Iberian NMR Meeting, 2021.
  14. Bispo, Daniela; Oliveira, Mariana; Mano, João F; Gil, Ana Maria Pissarra. "Finding biomarkers of mesenchymal stem cells osteogenic differentiation with nuclear mag-netic resonance (NMR)-based metabolomics". Trabalho apresentado em 2nd international workshop on advanced materials for healthcare applications, 2019.
  15. Bispo, Daniela; Fabris, Victoria; Lanari, Claudia; Helguero, Luisa; Gil, Ana Maria Pissarra. "Breast tumour heterogeneity: metabolomics of a mouse model". Trabalho apresentado em Jornadas CICECO - Universidade de Aveiro, 2019.
  16. Bispo, Daniela; Santos, Sónia A.O.; Pinto, Ricardo J.B.; Freire, Carmem S.R.. "Novel hybrid nanosystems based on gold nanoparticles and polysaccharides from algae for biomedical applications". Trabalho apresentado em 5th EPNOE International Polysaccharide Conference, 2017.
Tese / Dissertação
  1. Bispo, Daniela. "Estudo da heterogeneidade de tumores mamários: metabolómica de um modelo animal". Mestrado, Universidade de Aveiro, 2018. https://ria.ua.pt/handle/10773/25415.
  2. Bispo, Daniela. "Preparação de nano-sistemas com polissacarídeos provenientes de macroalgas para aplica-ções biomédicas". Licenciatura, Universidade de Aveiro, 2016.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/06/07 Understanding MSCs Osteogenesis Variability among Donors: a Step Forward with NMR Lipidomics 1st Lipids and Cell Plasticity Symposium: Implications for Tissue regeneration, Cancer and Immunology
Department of Medical Sciences, University of Aveiro (Aveiro, Portugal)
2023/07/13 Untargeted NMR exometabolomics for non-invasive osteodifferentiation monitoring Research summit 2023
University of Aveiro (Aveiro, Portugal)
2023/03/28 Non-invasive monitoring of mesenchymal stem cells osteodifferentiation by untargeted NMR exometabolomics Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Manchester, Reino Unido)
2023/03/28 Searching for donor-independent metabolic markers of MSC osteogenic differentiation by NMR metabolomics Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Manchester, Reino Unido)
2022/10/12 Metabolic markers of osteodifferentiating mesenchymal stem cells (video about PhD research project) Jornadas CICECO - Universidade de Aveiro
University of Aveiro (Aveiro, Portugal)
2022/07/14 Donor-independent metabolic adaptations during MSC osteogenesis Research summit 2022
University of Aveiro (Aveiro)
2022/06/30 NMR-based metabolomic analysis of endo- and exometabolome adaptations throughout osteogenic differentiation of adipose-derived mesenchymal stem cells Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Kraków, Polónia)
2022/06/30 Unveiling lipid metabolism underlying aging and osteogenesis of mesenchymal stem cells through 1H-NMR metabolomics Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Kraków, Polónia)
2022/06/21 The effect of osteogenic differentiation on endo- and exometabolome of human mesenchymal stem cells 8th International Iberian Biophysics Congress (IIBC2022)
Portuguese and Spanish Biophysical Societies (Bilbao, Espanha)
2021/07/07 Metabolic markers of osteogenic differentiation of MSCs by NMR metabolomics Research Summit 2021
University of Aveiro (Aveiro, Portugal)
2019/10 Metabolic heterogeneity of breast cancer tumours in a mouse model: a metabolomics approach III International Congress in Health Sciences Research: Towards Innovation and Entrepre-neurship - Trends in Aging and Cancer
(Covilhã, Portugal)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/06/12 - 2033/06/15 Attendance at the "In-cell NMR spectroscopy: principles and practice" (online) In-cell NMR spectroscopy: principles and practice (theoretical and hands-on NMR course)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/06/19 - 2023/06/23 Attendance at the XV International "Manuel Rico" NMR School
Outro
 XV International "Manuel Rico" NMR School
SPANISH ROYAL SOCIETY OF CHEMISTRY (RSEQ), Espanha
2023/04/19 - 2023/04/19 Attendance at the "DataStrategy" (modelação e visualização de grandes conjuntos de dados)
Seminário
 DataStrategy
Scientific Junior Value, Portugal
2023/03/31 - 2023/03/31 Attendance at "An NMR Testimonial: A Symposium Celebrating Gareth Morris's 40 Years at the University of Manchester"
Simpósio
 An NMR Testimonial: A Symposium Celebrating Gareth Morris's 40 Years at the University of Manchester
The University of Manchester, Reino Unido
2023/03/28 - 2023/03/31 Oral communication and attendance at "Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023"
Conferência
 Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023
2022/10/12 - 2022/10/12 Poster presentation, film presentation and attendance at Jornadas CICECO 22
Conferência
 Jornadas CICECO 22
Universidade de Aveiro, Portugal

Aveiro Institute of Materials (CICECO), Portugal
2022/06/28 - 2022/07/01 Oral presentation and attendance at TERMIS EU 2022
Conferência
 Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022
2022/06/20 - 2022/06/21 Oral presentation and attendance at IIBC2022
Congresso
 8th International Iberian Biophysics Congress (IIBC2022)
2022/03/26 - 2022/03/26 Attendance at "Gen Sci" - Investigação Biomédica, Bioempreendedorismo e Ilustração Científica
Seminário
 Gen Sci
2022/03/23 - 2022/03/23 Attendance at the 10th Workshop in Lipidomics (Food Lipidomics)
Oficina (workshop)
 10th Workshop in Lipidomics
Universidade de Aveiro, Portugal
2019/09/11 - 2019/09/11 Attendance at the "1st Iberian Seminar on NMR Metabolomics in Clinical Research"
Seminário
 1st Iberian Seminar on NMR Metabolomics in Clinical Research
Universidade de Aveiro, Portugal
2018/09/05 - 2018/09/14 Summer School in Computational Biology - direct contact learning activities.
Outro
 From Molecules to Tissues
Universidade de Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2022/04 - Atual Portuguese Society of Biochemistry (affiliated society - biophysic)

Tutoria

Tópico Nome do aluno
2024/05/01 - 2024/12/01 Cell Culture & Metabolomics data analysis Inês Graça
2023 - 2024 Metabolomics data analysis Ana Carvalho
2023 - 2024 Metabolomics data analysis Sabrina Barreira
2023 - 2024 Metabolomics data analysis Cristiana Martins
2022/10 - 2024 Cell Culture & Metabolomics data analysis Aliana Reis
2022/11 - 2022/12 Cell Culture Beatriz Cardoso
2020/02 - 2020/07 Cell Culture & Metabolomics data analysis (Diferenciação osteogénica das células estaminais de tecido adiposo humano: impacto no metabolismo lipídico celular) Marlene Correia
2020/01 - 2020/07 Cell Culture & Metabolomics data analysis (Diferenciação osteogénica das células estaminais de tecido adiposo humano: impacto no metabolismo celular) Filipa Ferreira
2020/01 - 2020/07 Cell Culture & Metabolomics data analysis Dámaris Maia
Distinções

Prémio

2022 Grant to attend the 8th International Iberian Biophysics Congress (IIBC2022)
Portuguese Biophysical Society (SPBf), Portugal