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Daniela S. C. Bispo is currently a PhD student of the Biotechnology Doctoral Program (specialization in Medical Biotechnology) at University of Aveiro. Under the supervision of Mariana B. Oliveira, João F. Mano and Ana M. Gil, she is characterizing the osteogenic differentiation of human stem cells through Nuclear Magnetic Resonance (NMR) metabolomics, work developed within the scope of the BIOIMPLANT project (A Metabolomics-guided Bioreactor for Improved Engineered Bone Implants, PTDC/BTM-ORG/28835/2017) and the BetterBone project (Metabolite-activated 3D stem cell differentiation into bone, 2022.04286.PTDC). Prior to her PhD, Daniela had a research fellow position in the BIOIMPLANT project, as well as in the ATLAS project (Bioengineered Autonomous Cell-biomaterials Devices for Generating Humanised Micro-tissues for Regenerative Medicine, ERC-2014-AdG-669858). Her academic background includes a master's degree in Biochemistry (specialization in Clinical Biochemistry) (2018) and a bachelor's degree in Biotechnology (2016), both at University of Aveiro.
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Identification

Personal identification

Full name
Daniela Sofia Cabedal Bispo

Citation names

  • Bispo, Daniela S. C.
  • Bispo, Daniela
  • Daniela S. C. Bispo
  • Daniela Bispo

Author identifiers

Ciência ID
3216-1DC4-59EE
ORCID iD
0000-0002-5813-5421

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English
Portuguese (Mother tongue)
Education
Degree Classification
2020 - 2024
Ongoing
 Biotecnologia (Doutoramento)
Universidade de Aveiro, Portugal
2023/10 - 2023/12
Concluded
 Visiting student (Outros)
University of Glasgow, United Kingdom

Centre for the Cellular Microenvironment (CeMi), United Kingdom
2023/06/19 - 2023/06/23
Concluded
 XV International "Manuel Rico" NMR School (Summer School) (Outros)
SPANISH ROYAL SOCIETY OF CHEMISTRY (RSEQ), Spain
 N.A.
2016/09/09 - 2018/11/15
Concluded
 Bioquímica (Mestrado)
Major in Bioquímica clínica
Universidade de Aveiro, Portugal
"Estudo da Heterogeneidade do Cancro da Mama: Metabolómica de um Modelo Murino" (THESIS/DISSERTATION)
 18.0
2018/09/05 - 2018/09/14
Concluded
 Summer School in Computational Biology - direct contact learning activities (Summer School) (Outros)
Universidade de Coimbra, Portugal
 N.A.
2013/09/10 - 2016/07/20
Concluded
 Biotecnologia (Licenciatura)
Universidade de Aveiro, Portugal
"Preparação de nano-sistemas com polissacarídeos provenientes de macroalgas para aplicações biomédicas" (THESIS/DISSERTATION)
 16.0
2010/09 - 2013/08/07
Concluded
 Curso Científico-Humanístico de Ciências e Tecnologias (Ensino secundário)
Escola Secundária de Ponte de Sor, Portugal
 18
Affiliation

Others

Category
Host institution 		Employer
2020/02/13 - 2020/08 Bolseira de investigação (mestre) Universidade de Aveiro, Portugal
Universidade de Aveiro, Portugal
2019/01/21 - 2020/01/20 Bolseira de Investigação (mestre) Universidade de Aveiro, Portugal
Projects

Grant

Designation Funders
2020/02/13 - 2020/07/01 ATLAS: Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine
669858
Master Student Fellow
Universidade de Aveiro, Portugal

Aveiro Institute of Materials (CICECO), Portugal
European Commission
Ongoing
2019/01/21 - 2020/01/20 BIOIMPLANT - A metabolomics-guided bioreactor for improved engineered bone implants
BioImplant
Master Student Fellow
Universidade de Aveiro, Portugal

Aveiro Institute of Materials (CICECO), Portugal
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2023/02/20 - Current BetterBone - Metabolite-activated 3D stem cell differentiation into bone
2022.04286.PTDC
Membro da equipa
Universidade de Aveiro, Portugal

Aveiro Institute of Materials (CICECO), Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Daniela S. C. Bispo; Correia, Marlene; Henriques de Jesus, Catarina Sofia; Oliveira, Mariana B.; Rodrigues, Joao E.A.; Mano, Joao F.; Gil, Ana M.. "Non-invasive monitoring of mesenchymal stem cells osteodifferentiation by untargeted NMR Exometabolomics". Paper presented in Jornadas CICECO 23, 2023.
  2. Correia, Marlene; Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Rodrigues, Joao E.A.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Unveiling early predictive markers of mesenchymal stem cells osteogenesis capacity through NMR metabolomics". Paper presented in Jornadas CICECO 23, 2023.
  3. Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Correia, Marlene; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Search for donor-independent endometabolome markers of proliferating and osteodifferentiating mesenchymal stem cells". Paper presented in Jornadas CICECO - Universidade de Aveiro, 2022.
  4. Correia, Marlene; Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Exometabolome variations during osteogenic differentiation: Donor-independent markers". Paper presented in Jornadas CICECO - Universidade de Aveiro, 2022.
  5. Jesus, Catarina S. H.; Bispo, Daniela S. C.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Lipid Metabolic Adaptations to Mesenchymal Stem Cells Osteogenesis and Aging by 1H NMR Metabolomics". Paper presented in 8th International Iberian Biophysics Congress (IIBC2022), 2022.
  6. Bispo, Daniela S. C.. "Endo- and exometabolome adaptations during osteogenic differentiation of adipose-derived mesenchymal stem cells". Paper presented in BIOPHYSICS FESTIVAL – 2nd Meeting of Young Biophysicists, 2022.
  7. Correia, Marlene; Bispo, Daniela S. C.; Catarina S. H. Jesus; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Stem cell footprinting during osteogenic differentiation". Paper presented in BIOPHYSICS FESTIVAL - 2nd Meeting of Young Biophysicists, 2022.
  8. Jesus, Catarina S. H.; Bispo, Daniela S. C.; Marlene Correia; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Characterization of lipidic markers of osteogenic differentiation of mesenchymal stem cells using 1h nmr metabolomics". Paper presented in BIOPHYSICS FESTIVAL - 2nd Meeting of Young Biophysicists, 2022.
  9. Bispo, Daniela S. C.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Osteogenic differentiation of human adipose-derived stem cells followed by NMR metabolomics". Paper presented in Jornadas CICECO 2021, 2021.
  10. Bispo, Daniela S. C.; Jesus, Catarina S. H.; Lenka Michálková; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Metabolic markers of osteogenic differentiation of human adipose-derived stem cells through NMR metabolomics". Paper presented in EUROMAR, A European Magnetic Resonance Meeting, 2021.
  11. Bispo, Daniela; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Monitoring osteogenic differentiation with nuclear magnetic resonance (NMR)-based metabolomics". Paper presented in 9th Ibero-American NMR Meeting, 10th GERMN Biennial Meeting and the 7th Iberian NMR Meeting, 2021.
  12. Bispo, Daniela; Oliveira, Mariana; Mano, João F; Gil, Ana Maria Pissarra. "Finding biomarkers of mesenchymal stem cells osteogenic differentiation with nuclear mag-netic resonance (NMR)-based metabolomics". Paper presented in 2nd international workshop on advanced materials for healthcare applications, 2019.
  13. Bispo, Daniela; Fabris, Victoria; Lanari, Claudia; Helguero, Luisa; Gil, Ana Maria Pissarra. "Breast tumour heterogeneity: metabolomics of a mouse model". Paper presented in Jornadas CICECO - Universidade de Aveiro, 2019.
Journal article
  1. Bispo, Daniela S. C.; Correia, Marlene; Carneiro, Tatiana J.; Martins, Ana S. ; Reis, Aliana A. N.; Carvalho, Ana L. M. Batista de; Marques, Maria P. M.; Gil, Ana M.. "Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells". International Journal of Molecular Sciences 24 24 (2023): 17556. http://dx.doi.org/10.3390/ijms242417556.
    10.3390/ijms242417556
  2. Rodrigues, João A.; Bispo, Daniela S. C. (shared first authorship); Silva, Mónica G.; Araújo, Rita; Soares, Amadeu M. V. M.; Freitas, Rosa; Gil, Ana M.. "Impact of Sea Warming and 17-a-Ethinylestradiol Exposure on the Lipid Metabolism of Ruditapes philippinarum Clams". International Journal of Molecular Sciences 24 11 (2023): 9485. http://dx.doi.org/10.3390/ijms24119485.
    Published • 10.3390/ijms24119485
  3. Bispo, Daniela S. C.; Henriques de Jesus, Catarina Sofia; Romek, Katarzyna; Marques, Inês M. C.; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "An Intracellular Metabolic Signature as a Potential Donor-Independent Marker of the Osteogenic Differentiation of Adipose Tissue Mesenchymal Stem Cells". Cells 11 23 (2022): 3745. https://www.mdpi.com/2073-4409/11/23/3745.
    Open access • Published
  4. Bispo, Daniela S. C.; Lenka Michálková; Correia, Marlene; Jesus, Catarina S. H.; Duarte, Iola F; Brian J. Goodfellow; Oliveira, Mariana B.; Mano, Joao F.; Gil, Ana M.. "Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation". Cells 11 8 (2022): 1257. https://www.mdpi.com/2073-4409/11/8/1257.
    Open access • Published • 10.3390/cells11081257
  5. Daniela S. C. Bispo; Catarina S. H. Jesus; Marlene Correia; Filipa Ferreira; Giulia Bonifazio; Brian J. Goodfellow; Mariana B. Oliveira; João F. Mano; Ana M. Gil. "NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells". Journal of Proteome Research 21 3 (2022): 654-670. https://doi.org/10.1021/acs.jproteome.1c00832.
    Published • 10.1021/acs.jproteome.1c00832
  6. Bispo, Daniela S. C.; Jesus, Catarina S. H.; Marques, Inês M. C.; Romek, Katarzyna M.; Oliveira, Mariana B.; Mano, João F.; Gil, Ana M.. "Metabolomic Applications in Stem Cell Research: a Review". Stem Cell Reviews and Reports 17 6 (2021): 2003-2024. http://dx.doi.org/10.1007/s12015-021-10193-z.
    10.1007/s12015-021-10193-z
  7. Bispo, Daniela; Fabris, Victoria; Lamb, Caroline A.; Lanari, Claudia; Helguero, Luisa A.; Gil, Ana M.. "Hormone-Independent Mouse Mammary Adenocarcinomas with Different Metastatic Potential Exhibit Different Metabolic Signatures". Biomolecules 10 9 (2020): 1242. http://dx.doi.org/10.3390/biom10091242.
    10.3390/biom10091242
  8. Araújo, Rita; Bispo, Daniela; Helguero, Luisa A.; Gil, Ana M.. "Metabolomic studies of breast cancer in murine models: A review". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 5 (2020): 165713. http://dx.doi.org/10.1016/j.bbadis.2020.165713.
    Published • 10.1016/j.bbadis.2020.165713
  9. Pinto, Ricardo J. B.; Bispo, Daniela; Vilela, Carla; Botas, Alexandre M. P.; Ferreira, Rute A. S.; Menezes, Ana C.; Campos, Fábio; et al. "One-Minute Synthesis of Size-Controlled Fucoidan-Gold Nanosystems: Antitumoral Activity and Dark Field Imaging". Materials 13 5 (2020): 1076. http://dx.doi.org/10.3390/ma13051076.
    Open access • Published • 10.3390/ma13051076
Thesis / Dissertation
  1. Bispo, Daniela. "Estudo da heterogeneidade de tumores mamários: metabolómica de um modelo animal". Master, Universidade de Aveiro, 2018. https://ria.ua.pt/handle/10773/25415.
  2. Bispo, Daniela. "Preparação de nano-sistemas com polissacarídeos provenientes de macroalgas para aplica-ções biomédicas". Degree, Universidade de Aveiro, 2016.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/07/13 Untargeted NMR exometabolomics for non-invasive osteodifferentiation monitoring Research summit 2023
University of Aveiro (Aveiro, Portugal)
2023/03/28 Non-invasive monitoring of mesenchymal stem cells osteodifferentiation by untargeted NMR exometabolomics Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Manchester, United Kingdom)
2023/03/28 Searching for donor-independent metabolic markers of MSC osteogenic differentiation by NMR metabolomics Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Manchester, United Kingdom)
2022/10/12 Metabolic markers of osteodifferentiating mesenchymal stem cells (video about PhD research project) Jornadas CICECO - Universidade de Aveiro
University of Aveiro (Aveiro, Portugal)
2022/07/14 Donor-independent metabolic adaptations during MSC osteogenesis Research summit 2022
University of Aveiro (Aveiro)
2022/06/30 NMR-based metabolomic analysis of endo- and exometabolome adaptations throughout osteogenic differentiation of adipose-derived mesenchymal stem cells Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Kraków, Poland)
2022/06/30 Unveiling lipid metabolism underlying aging and osteogenesis of mesenchymal stem cells through 1H-NMR metabolomics Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Kraków, Poland)
2022/06/21 The effect of osteogenic differentiation on endo- and exometabolome of human mesenchymal stem cells 8th International Iberian Biophysics Congress (IIBC2022)
Portuguese and Spanish Biophysical Societies (Bilbao, Spain)
2021/07/07 Metabolic markers of osteogenic differentiation of MSCs by NMR metabolomics Research Summit 2021
University of Aveiro (Aveiro, Portugal)
2019/10 Metabolic heterogeneity of breast cancer tumours in a mouse model: a metabolomics approach III International Congress in Health Sciences Research: Towards Innovation and Entrepre-neurship - Trends in Aging and Cancer
(Covilhã, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/12 - 2033/06/15 Attendance at the "In-cell NMR spectroscopy: principles and practice" (online) In-cell NMR spectroscopy: principles and practice (theoretical and hands-on NMR course)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/06/19 - 2023/06/23 Attendance at the XV International "Manuel Rico" NMR School
Other
 XV International "Manuel Rico" NMR School
SPANISH ROYAL SOCIETY OF CHEMISTRY (RSEQ), Spain
2023/04/19 - 2023/04/19 Attendance at the "DataStrategy" (modelação e visualização de grandes conjuntos de dados)
Seminar
 DataStrategy
Scientific Junior Value, Portugal
2023/03/31 - 2023/03/31 Attendance at "An NMR Testimonial: A Symposium Celebrating Gareth Morris's 40 Years at the University of Manchester"
Symposium
 An NMR Testimonial: A Symposium Celebrating Gareth Morris's 40 Years at the University of Manchester
The University of Manchester, United Kingdom
2023/03/28 - 2023/03/31 Oral communication and attendance at "Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023"
Conference
 Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2023
2022/10/12 - 2022/10/12 Poster presentation, film presentation and attendance at Jornadas CICECO 22
Conference
 Jornadas CICECO 22
Universidade de Aveiro, Portugal

Aveiro Institute of Materials (CICECO), Portugal
2022/06/28 - 2022/07/01 Oral presentation and attendance at TERMIS EU 2022
Conference
 Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022
2022/06/20 - 2022/06/21 Oral presentation and attendance at IIBC2022
Congress
 8th International Iberian Biophysics Congress (IIBC2022)
2022/03/26 - 2022/03/26 Attendance at "Gen Sci" - Investigação Biomédica, Bioempreendedorismo e Ilustração Científica
Seminar
 Gen Sci
2022/03/23 - 2022/03/23 Attendance at the 10th Workshop in Lipidomics (Food Lipidomics)
Workshop
 10th Workshop in Lipidomics
Universidade de Aveiro, Portugal
2019/09/11 - 2019/09/11 Attendance at the "1st Iberian Seminar on NMR Metabolomics in Clinical Research"
Seminar
 1st Iberian Seminar on NMR Metabolomics in Clinical Research
Universidade de Aveiro, Portugal
2018/09/05 - 2018/09/14 Summer School in Computational Biology - direct contact learning activities.
Other
 From Molecules to Tissues
Universidade de Coimbra, Portugal

Association member

Society Organization name Role
2022/04 - Current Portuguese Society of Biochemistry (affiliated society - biophysic)

Mentoring / Tutoring

Topic Student name
2022/10 - 2023/03 Cell Culture Aliana Reis
2022/11 - 2022/12 Cell Culture Beatriz Cardoso
2020/02 - 2020/07 Diferenciação osteogénica das células estaminais de tecido adiposo humano: impacto no metabolismo lipídico celular Marlene Correia
2020/01 - 2020/07 Diferenciação osteogénica das células estaminais de tecido adiposo humano: impacto no metabolismo celular Filipa Ferreira
2020/01 - 2020/07 Cell Culture Dámaris Maia
Distinctions

Award

2022 Grant to attend the 8th International Iberian Biophysics Congress (IIBC2022)
Portuguese Biophysical Society (SPBf), Portugal