Leonardo de Souza Mesquita is currently a Post-doc Researcher at CICECO - Aveiro Institute of Material (Portugal) and at the University of Campinas (Brazil) hired under Project FAPESP - Integrated biorefinery of agricultural waste to obtain natural dyes and value-added bioactive compounds (call FAPESP 2021/11022-1). In 2014 he received a BSc degree in Biology from the University of São Paulo State (UNESP), Brazil, and in 2017 he obtained his MSc degree in Science at the same university. In 2021, he completed his Ph.D. in Science at the Federal University of São Paulo (UNIFESP – Brazil). During his research, Leonardo developed several alternative extraction processes using non-volatile alternative solvents to valorize wastes from food and marine sources. Leonardo de Souza Mesquita's primary goal of scientific investigation is to apply green solvents (ionic liquids and deep eutectic solvents) for biomass valorization and to improve the color stability of natural colorants. He also has collaboration projects with industries (cosmetic and chemical). In addition, he also has experience in Molecular Biology, chromatography (UHPLC, LC, GC), and spectrophotometry (UV, MS, PDA) for the identification and quantification of natural bioactive compounds. Since 2017 he has published 38 SCI papers in international peer-reviewed journals, 4 book chapters, and 4 patents, with more than 100 distinct authors spread worldwide. Moreover, he has contributed with +40 oral and poster communications and was gained 7 distinct honorary merits and awards.

Identificação pessoal

Nome completo
Leonardo Mendes de Souza Mesquita

Nomes de citação

  • de Souza Mesquita, Leonardo
  • Mesquita, L.M.S.

Identificadores de autor

Ciência ID
Google Scholar ID

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Engenharia Química
  • Ciências Naturais - Ciências Biológicas - Botânica
  • Ciências Exatas - Química - Química Analítica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Tecnologias de BioProcessamento


Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Italiano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Grau Classificação
2021/02/01 - 2024/02/01
Em curso
Post Doc in Science (Postgraduate Certificate)
Universidade Estadual de Campinas, Brasil
2022/04/01 - 2023/04/01
Em curso
Pós Doutorado em Engenharia Química (Pós-doutoramento)
Universidade de Aveiro, Portugal
2017/06/01 - 2021/01/18
Ciências (Doctor)
Especialização em Interdisciplinar em ciências da saúde
Universidade Federal de São Paulo, Brasil
"Desenvolvimento de processos químicos sustentáveis para extração de carotenoides de Bactris gasipaes: aplicações tecnológicas e nutricionais" (TESE/DISSERTAÇÃO)
2015/01/01 - 2017/01/01
Mestrado em Ciências (Master)
Universidade Estadual Paulista Júlio de Mesquita Filho, Brasil
"Fitoterápicos padronizados para o tratamento de doenças crônicas: Rhizophora mangle," (TESE/DISSERTAÇÃO)
2009/01/01 - 2013/01/01
Biology (Bachelor)
Especialização em Biotecnology and botany
Universidade Estadual Paulista Júlio de Mesquita Filho, Brasil
Percurso profissional


Categoria Profissional
Instituição de acolhimento
2022/04/01 - Atual Pós-doutorado (Investigação) Universidade de Aveiro, Portugal
2021/02/01 - Atual Pós-doutorado (Investigação) Universidade Estadual de Campinas, Brasil


Designação Financiadores
2021/02/01 - 2024/02/01 Application of non-volatile alternative solvents to create sustainable two-dimensional and integrated platforms for harnessing agro-industrial waste from jaboticaba and pomegranate fruits
Bolseiro de Pós-Doutoramento
Universidade Estadual de Campinas, Brasil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Em curso
2022/04/01 - 2023/04/01 Integrated biorefinery of agricultural wastes to obtain natural dyes and value-added bioactive compounds
Bolseiro de Pós-Doutoramento
Universidade de Aveiro, Portugal
Fundação de Amparo à Pesquisa do Estado de São Paulo
Em curso
2017/06/01 - 2021/01/18 Carotenoids extraction from Bactris gasipaes with ionic liquids and its application in metabolic programming model
Bolseiro de Doutoramento
Fundação de Amparo à Pesquisa do Estado de São Paulo
2015/04/01 - 2019/01/31 Standardized phytotherapics for the treatment of chronicle diseases: Rhizophora mangle
Bolseiro de Mestrado
2013/09/10 - 2014/01/09 Isolation and identification of secondary metabolites from Plantago catharinea (Plantaginaceaee) leaves
Bolseiro de Mestrado


Artigo em revista
  1. Contieri, Letícia S.; de Souza Mesquita, Leonardo M.; Sanches, Vitor L.; Viganó, Juliane; Martinez, Julian; da Cunha, Diogo T.; Rostagno, Mauricio A.. "Standardization proposal to quality control of propolis extracts commercialized in Brazil : A fingerprinting methodology using a UHPLC-PDA-MS/MS approach". Food Research International 161 (2022): 111846. http://dx.doi.org/10.1016/j.foodres.2022.111846.
  2. Contieri, Letícia S.; de Souza Mesquita, Leonardo M.; Sanches, Vitor L.; Chaves, Jaísa; Pizani, Rodrigo S.; da Silva, Laíse C.; Viganó, Juliane; Ventura, Sónia P.M.; Rostagno, Maurício A.. "Recent progress on the recovery of bioactive compounds obtained from propolis as a natural resource: Processes, and applications". Separation and Purification Technology 298 (2022): 121640. http://dx.doi.org/10.1016/j.seppur.2022.121640.
  3. de Souza, Mariana C.; de Souza Mesquita, Leonardo M.; Pena, Fabíola L.; Tamborlin, Leticia; da Silva, Laise C.; Viganó, Juliane; Antunes, Adriane E. Costa; et al. "Potential application for antimicrobial and antileukemic therapy of a flavonoid-rich fraction of Camellia sinensis". Food Chemistry Advances 1 (2022): 100042. http://dx.doi.org/10.1016/j.focha.2022.100042.
  4. Pizani, Rodrigo S.; Viganó, Juliane; de Souza Mesquita, Leonardo M.; Contieri, Letícia S.; Sanches, Vitor L.; Chaves, Jaísa O.; Souza, Mariana C.; da Silva, Laise C.; Rostagno, Maurício A.. "Beyond aroma: A review on advanced extraction processes from rosemary (Rosmarinus officinalis) and sage (Salvia officinalis) to produce phenolic acids and diterpenes". Trends in Food Science & Technology 127 (2022): 245-262. http://dx.doi.org/10.1016/j.tifs.2022.07.001.
  5. Sanches, Vitor L.; de Souza Mesquita, Leonardo M.; Viganó, Juliane; Contieri, Letícia S.; Pizani, Rodrigo; Chaves, Jaísa; da Silva, Laíse Capelasso; et al. "Insights on the Extraction and Analysis of Phenolic Compounds from Citrus Fruits: Green Perspectives and Current Status". Critical Reviews in Analytical Chemistry (2022): 1-27. http://dx.doi.org/10.1080/10408347.2022.2107871.
  6. Chaves, Jaisa O.; Sanches, Vitor L.; Viganó, Juliane; de Souza Mesquita, Leonardo M.; de Souza, Mariana C.; da Silva, Laise C.; Acunha, Tanize; Faccioli, Lucia H.; Rostagno, Mauricio A.. "Integration of pressurized liquid extraction and in-line solid-phase extraction to simultaneously extract and concentrate phenolic compounds from lemon peel (Citrus limon L.)". Food Research International 157 (2022): 111252. http://dx.doi.org/10.1016/j.foodres.2022.111252.
  7. Sertorio, Marcela Nascimento; César, Helena; de Souza, Esther Alves; Mennitti, Laís Vales; Santamarina, Aline Boveto; De Souza Mesquita, Leonardo Mendes; Jucá, Andréa; et al. "Parental High-Fat High-Sugar Diet Intake Programming Inflammatory and Oxidative Parameters of Reproductive Health in Male Offspring". Frontiers in Cell and Developmental Biology 10 (2022): http://dx.doi.org/10.3389/fcell.2022.867127.
  8. Sanches, Vitor L.; Cunha, Tanize A.; Viganó, Juliane; de Souza Mesquita, Leonardo M.; Faccioli, Lúcia Helena; Breitkreitz, Marcia Cristina; Rostagno, Maurício A.. "Comprehensive analysis of phenolics compounds in citrus fruits peels by UPLC-PDA and UPLC-Q/TOF MS using a fused-core column". Food Chemistry: X 14 (2022): 100262. http://dx.doi.org/10.1016/j.fochx.2022.100262.
  9. Fantatto, Rafaela Regina; Chagas, Ana Carolina de Souza; Gainza, Yousmel Alemán; Politi, Flávio Augusto Sanches; Mesquita, Leonardo Mendes de Souza; Vilegas, Wagner; Bizzo, Humberto Ribeiro; Montanari Junior, Ílio; Pietro, Rosemeire Cristina Linhari Rodrigues. "Acaricidal and anthelmintic action of ethanolic extract and essential oil of Achyrocline satureioides". Experimental Parasitology 236-237 (2022): 108252. http://dx.doi.org/10.1016/j.exppara.2022.108252.
  10. Santamarina, Aline B.; de Souza Mesquita, Leonardo M.; Casagrande, Breno P.; Sertorio, Marcela N.; Vitor de Souza, Daniel; Mennitti, Laís V.; Ribeiro, Daniel A.; et al. "Supplementation of carotenoids from peach palm waste (Bactris gasipaes) obtained with an ionic liquid mediated process displays kidney anti-inflammatory and antioxidant outcomes". Food Chemistry: X 13 (2022): 100245. http://dx.doi.org/10.1016/j.fochx.2022.100245.
  11. "Using aqueous solutions of ionic liquids as chlorophyll eluents in solid-phase extraction processes". Chemical Engineering Journal 428 (2022): 131073-131073. http://dx.doi.org/10.1016/j.cej.2021.131073.
  12. "Recent advances and trends in extraction techniques to recover polyphenols compounds from apple by-products". Food Chemistry: X 12 (2021): 100133-100133. http://dx.doi.org/10.1016/j.fochx.2021.100133.
  13. Juliane Viganó; Vitor L. Sanches; Leonardo M. de Souza Mesquita; Mariana C. de Souza; Laise C. da Silva; Jaísa O. Chaves; Tânia Forster-Carneiro; Mauricio A. Rostagno. "Comprehensive analysis of phenolic compounds from natural products: Integrating sample preparation and analysis". Analytica Chimica Acta 1178 (2021): 338845-338845. https://doi.org/10.1016/j.aca.2021.338845.
  14. "Improvement of Bioactive Compound Levels, Antioxidant Activity, and Bioaccessibility of Carotenoids from Pereskia aculeata after Different Cooking Techniques". ACS Food Science & Technology 1 7 (2021): 1285-1293. http://dx.doi.org/10.1021/acsfoodscitech.1c00162.
  15. Leonardo M. de Souza Mesquita; Daniella Carisa Murador; Bruna Vitória Neves; Anna Rafaela Cavalcante Braga; Luciana Pellegrini Pisani; Veridiana Vera de Rosso. "Bioaccessibility and Cellular Uptake of Carotenoids Extracted from Bactris gasipaes Fruit: Differences between Conventional and Ionic Liquid-Mediated Extraction". Molecules (2021): https://doi.org/10.3390/molecules26133989.
  16. "Red Propolis as a Source of Antimicrobial Phytochemicals: Extraction Using High-Performance Alternative Solvents". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.659911.
  17. "Extraction and Fractionation of Pigments from Saccharina latissima (Linnaeus, 2006) Using an Ionic Liquid + Oil + Water System". ACS Sustainable Chemistry & Engineering 9 19 (2021): 6599-6612. http://dx.doi.org/10.1021/acssuschemeng.0c09110.
  18. Helen Colbachini; Cristiane Schilbach Pizzutto; Leonardo Mendes de Souza Mesquita; Otto Bismarck Fazzano Gadig. "Environmental enrichment effects on the reproductive behavior of captive nurse sharks Ginglymostoma cirratum". Environmental Biology of Fishes 104 4 (2021): 471-488. https://doi.org/10.1007/s10641-021-01087-7.
  19. Daniella C. Murador; Leonardo M. De Souza Mesquita; Bruna V. Neves; Anna R.C. Braga; Paula L.G. Martins; Leila Q. Zepka; Veridiana V. De Rosso. "Bioaccessibility and cellular uptake by Caco-2 cells of carotenoids and chlorophylls from orange peels: A comparison between conventional and ionic liquid mediated extractions". Food Chemistry 339 (2021): 127818-127818. https://doi.org/10.1016/j.foodchem.2020.127818.
  20. Leonardo M. Souza Mesquita; Margarida Martins; Luciana P. Pisani; Sónia P. M. Ventura; Veridiana V. Rosso. "Insights on the use of alternative solvents and technologies to recover bio-based food pigments". Comprehensive Reviews in Food Science and Food Safety (2021): https://doi.org/10.1111/1541-4337.12685.
  21. "The role of vitamin A and its pro-vitamin carotenoids in fetal and neonatal programming: gaps in knowledge and metabolic pathways". Nutrition Reviews 79 1 (2021): 76-87. http://dx.doi.org/10.1093/nutrit/nuaa075.
  22. Leonardo M. de Souza Mesquita; Breno P. Casagrande; Aline B. Santamarina; Marcela N. Sertorio; Daniel Vitor de Souza; Laís V. Mennitti; Andrea Jucá; et al. "Carotenoids obtained from an ionic liquid-mediated process display anti-inflammatory response in the adipose tissue-liver axis". Food & Function (2021): https://doi.org/10.1039/D1FO01429C.
  23. "Ionic Liquid-Mediated Recovery of Carotenoids from the Bactris gasipaes Fruit Waste and Their Application in Food-Packaging Chitosan Films". ACS Sustainable Chemistry & Engineering 8 10 (2020): 4085-4095. http://dx.doi.org/10.1021/acssuschemeng.9b06424.
  24. "Mayonnaise as a model food for improving the bioaccessibility of carotenoids from Bactris gasipaes fruits". LWT 122 (2020): 109022-109022. http://dx.doi.org/10.1016/j.lwt.2020.109022.
  25. "Bioavailability and biological effects of bioactive compounds extracted with natural deep eutectic solvents and ionic liquids: advantages over conventional organic solvents". Current Opinion in Food Science 26 (2019): 25-34. http://dx.doi.org/10.1016/j.cofs.2019.03.002.
  26. "Brazilian Biodiversity Fruits: Discovering Bioactive Compounds from Underexplored Sources". Journal of Agricultural and Food Chemistry 67 7 (2019): 1860-1876. http://dx.doi.org/10.1021/acs.jafc.8b05815.
  27. "LC–ESI–IT-MS/MS and MALDI-TOF Approach: Identification of Natural Polymers from Rhizophora mangle Barks and Determination of Their Analgesic and Anti-inflammatory Properties". Natural Products and Bioprospecting 9 1 (2019): 23-34. http://dx.doi.org/10.1007/s13659-018-0192-8.
  28. "Ionic liquid-high performance extractive approach to recover carotenoids from Bactris gasipaes fruits". Green Chemistry 21 9 (2019): 2380-2391. http://dx.doi.org/10.1039/c8gc03283a.
  29. "Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice". Molecules 23 9 (2018): 2114-2114. http://dx.doi.org/10.3390/molecules23092114.
  30. "Lactobacillus fermentation of jussara pulp leads to the enzymatic conversion of anthocyanins increasing antioxidant activity". Journal of Food Composition and Analysis 69 (2018): 162-170. http://dx.doi.org/10.1016/j.jfca.2017.12.030.
  31. "Bioavailability of anthocyanins: Gaps in knowledge, challenges and future research". Journal of Food Composition and Analysis 68 (2018): 31-40. http://dx.doi.org/10.1016/j.jfca.2017.07.031.
  32. "Application of electrospray ionization mass spectrometry fingerprinting associated with macroscopic and histological analysis for Plantago major herbal infusions quality control". Food Research International 107 (2018): 314-324. http://dx.doi.org/10.1016/j.foodres.2018.02.031.
  33. Leonardo Mendes de Souza Mesquita; Karine Delevati Colpo; Cláudia Quintino da Rocha; Douglas Gatte-Picchi; Marcelo Marucci Pereira Tangerina; Beatriz Zachello-Nunes; Maria Bernadete Gonçalves Martins; Wagner Vilegas. "Anatomical differentiation and metabolomic profiling: a tool in the diagnostic characterization of some medicinal Plantago species". Brazilian Journal of Botany (2017): https://doi.org/10.1007/s40415-017-0388-x.
  34. "South American herbal extracts reduce food intake through modulation of gastrointestinal hormones in overweight and obese women". Journal of Functional Foods 35 (2017): 555-563. http://dx.doi.org/10.1016/j.jff.2017.06.015.
  35. "Modulatory Effects of Guarana (Paullinia cupana) on Adipogenesis". Nutrients 9 6 (2017): 635-635. http://dx.doi.org/10.3390/nu9060635.
  36. "Phenolic Isomers from Plantago Catharinea Leaves: Isolation, Identification, Quantification and in Vitro Antioxidant Activity". Natural Product Communications 12 3 (2017): 1934578X1701200-1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200326.
  37. "Isolation, identification, quantification and antioxidant activity of secondary metabolites from coastal Brazilian herbs". Planta Medica 80 16 (2014): http://dx.doi.org/10.1055/s-0034-1394762.
Capítulo de livro
  1. Laís Vales Menniti; Ana Claudia Losinskas Hachul; de Souza Mesquita, Leonardo; Lila Missae Oyama; Luciana Pellegrini Pisani. "Compostos bioativos dos alimentos no início da vida e prevenção de doenças crônicas no adulto". In Nutrição No Início Da Vida, Evidências científicas para prevenção de doenças. 2022.
  2. Contieri, Letícia S.; Sanches, Vitor L.; da Silva, Laise C.; de Souza Mesquita, Leonardo M.; Rostagno, Mauricio A.. "Chapter 10. On-line and In-line Analysis of Natural Extracts". In Natural Product Extraction, 429-458. Royal Society of Chemistry, 2022.
  3. de Souza Mesquita, Leonardo. "Um só idioma". Aveiro, Portugal, 2022.
  4. "Application of Ionic Liquid Solvents in the Food Industry". 1-16. Springer Singapore, 2019.

Propriedade Intelectual

  1. Maurício Ariel Rostagno; jaisa chaves; Juliane Viganó; Vitor Lacerda Sanches; de Souza, Mariana Corrêa; da Silva, Laíse Capelasso; de Souza Mesquita, Leonardo. 2022. "SEPARATION PROCESS OF PHENOLIC COMPOUNDS IN VEGETABLE MATRICES".
  2. de Souza Mesquita, Leonardo; Maurício Ariel Rostagno; Juliane Viganó; leticia Sanches Contieri; Vitor Lacerda Sanches. 2021. "PROCESSO DE EXTRAÇÃO DE ANTOCIANINAS".
  3. Maurício Ariel Rostagno; Ulisses Campinas; Tânia Forster-Carneiro; Jaisa Oliveira Chaves; Juliane Viganó; Laise Capelasso da Silva; Mariana Souza; Vitor Lacerda Sanches; de Souza Mesquita, Leonardo. 2021. "SEPARATION PROCESS OF COMPOUNDS FROM VEGETABLE MATRICES WITH ONLINE DETECTION".
  4. de Souza Mesquita, Leonardo; Caroline Bittencourt Fabri; Vilegas, Wagner; Marcos Hikari Toyama; Cláudia Quintino da Rocha; Henrique Hessel Gaeta; Mariana Novo Belchor. 2017. "PROCESS FOR OBTAINING THE RHIZOPHORA MANGLE EXTRACT AND ITS USE"". Brasil.


Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2022/09/01 - Atual Fractionation of pigments and proteins using centrifugal force chromatograph (CPC).
Universidade de Aveiro CICECO, Portugal
2021/02/01 - 2025/02/01 Development of sustainable methods for propolis extracts by the application of non-volatile alternative solvents

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2016/02/03 - Atual Workshop of the Aquatic Biodiversity (2016/02/03)
Oficina (workshop) (Presidente da Comissão Organizadora)
Universidade Estadual Paulista Júlio de Mesquita Filho, Brasil

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2015/04/04 CHALLENGES FOR NEW RESEARCHERS. Journal of the São Paulo State University

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2021/10/04 - Atual Journal of Molecular Liquids
2021/06/02 - Atual Food Chemistry: X
2021/06/01 - Atual Helyon
2020/01/01 - Atual The Journal of Nutrition
2019/01/01 - Atual Diabetology & Metabolic Syndrome


Tópico Nome do aluno
2021/02/05 - 2022/10/03 Development of functional breads with partially defatted sunflower seed flour Beatriz Carolina Amorim Forli
2021/02/01 - 2022/10/01 Development of functional breads with aqueous extract obtained from the by-product of sunflower oil production Vitoria Bernardino Togni
2018/02/04 - 2019/02/04 pplication of electrospray ionization mass spectrometry fingerprinting associated with macroscopic and histological analysis for Plantago major herbal infusions quality control. Carolina Gomes de Andrade.


2022 Menção Honrosa Prêmio Capes de Tese - Área Interdisciplinar, Fundação Coordenação de Aperfeiçoamento de Pessoal e Nivel Superior.
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil
2017 Menção Honrosa - 1º lugar na categoria poster - VI Simpósio de Plantas medicinais do Vale do São Francisco.
2015 Estudante selecionado para participar da Jornada dos Jóvenes Investigadores (La Plata - Argentina), AREX
2014 Menção honrosa - Melhor trabalho do XXVI Congresso de Iniciação Científica da Unesp: Identificação, quantificação e atividade antirradicalar de isômeros de Plantago catharinea (Plantaginaceae), XXVI Congresso de Iniciação Científica da Unesp.

Outra distinção

2021 Capa do periódico ACS - Sustainable Chemistry & Engineering - 2021, v.9, 19, 6507-6893
ACS Publications, Estados Unidos
2020 Capa do periódico ACS - Sustainable Chemistry & Engineering - 2020, 8, 10, 4085-4095
ACS Publications, Estados Unidos
2014 Menção Honrosa da 1ª fase do congresso de Iniciação científica da UNESP - trabalho selecionado, UNESP.