Paulo Aguiar graduated in Physics ("Engª Física Tecnológica") from Instituto Superior Técnico, University of Lisbon, Portugal, and completed the course work in the Biophysics Doctoral Program at the Institute for Biophysics and Biomedical Engineering, University of Lisbon in 2001 (final grade 95/100, among the highest achieved in the program). He then moved to the United Kingdom to continue his studies at the Institute for Adaptive and Neural Computation, University of Edinburgh. After finishing his PhD in Computational Neuroscience (U. Edinburgh, 2006) he joined, as a postdoc in neurobiology, the Neuroscience Unit at the Institute for Molecular and Cellular Biology, Portugal. In 2008 he was awarded a competitive researcher grant in Computational Biology, and in 2013 he was invited to join the National Institute for Biomedical Engineering (INEB) as an Assistant Investigator. Since 2016 he is a Principal Investigator at the Institute for Research and Innovation in Health (i3S), the largest R&D institution for health sciences research in Portugal, where he leads the Neuroengineering and Computational Neuroscience Lab (NCN). Sign of his scientific recognition, he was elected in 2019 Vice-Coordinator of the Neurobiology and Neurologic Disorders Research Program at i3S (harboring 23 research groups). He is also invited Associate Prof. at ICBAS, invited Associate Prof. in Neuroengineering at Faculty of Engineering, and Affiliate Prof. in Biophysics at Faculty of Medicine, all at Univ. of Porto. He has been responsible for several courses in physics, mathematics, neurobiology and engineering, and has received a Univ. of Porto Pedagogical Score of 6.7/7.0 by the students. He has supervised and co-supervised 16 PhD students (completed + ongoing). Paulo Aguiar is author in 70+ international peer-reviewed publications (including in Science, Nature Cell Biology, J. Neuroscience, PNAS, J. Neural Eng., Medical Image Analysis; over 2920 citations and an h-factor of 24). He has been already (co)PI/Task Leader in 18 national and international research projects, obtained in competitive calls.

Identificação pessoal

Nome completo
Paulo de Castro Aguiar

Nomes de citação

  • Aguiar, Paulo

Identificadores de autor

Ciência ID
Google Scholar ID
Scopus Author Id

Endereços de correio eletrónico

  • pauloaguiar@i3s.up.pt (Profissional)


  • 220408800 (Profissional)


  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)


Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Engenharia Médica
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Exatas - Ciências da Computação e da Informação - Bioinformática
  • Ciências Naturais - Ciências Biológicas - Biofísica
  • Ciências Exatas - Ciências da Computação e da Informação - Ciências da Informação
  • Ciências Exatas - Ciências da Computação e da Informação - Ciências da Computação


Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1)
Japonês Utilizador elementar (A1) Utilizador elementar (A1)
Grau Classificação
PhD (Doctor of Philosophy)
The University of Edinburgh Institute for Adaptive and Neural Computation, Reino Unido
"A General Hippocampal Computational Model: Episodic and Spatial Memory Combined in a Spiking Model" (TESE/DISSERTAÇÃO)
2003/08/01 - 2003/08/31
Advanced Course in Computational Neuroscience (Outros)
IBRO - International Brain Research Organization, França
Doctoral Training Program in Biophysics and Biomedical Engineering (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal
1995/09/01 - 2000/07/31
Engenharia Física Tecnológica (Mestrado integrado)
Instituto Superior Técnico Departamento de Física, Portugal
Percurso profissional


Categoria Profissional
Instituição de acolhimento
2022/01/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/11/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/05/02 - 2016/10/31 Investigador Auxiliar (carreira) (Investigação) Instituto Nacional de Engenharia Biomédica, Portugal
2015/02/01 - 2015/02/15 Investigador visitante (Investigação) Universiteit Antwerpen Campus Drie Eiken, Bélgica
2008/05/02 - 2013/05/01 Investigador Auxiliar (carreira) (Investigação) Universidade do Porto Faculdade de Ciências, Portugal
2006/06/22 - 2008/05/01 Pós-doutorado (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
2017 - Atual Professor Associado Convidado (Docente Universitário) Universidade do Porto Faculdade de Engenharia, Portugal
2021/01 - 2022 Professor Associado Convidado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
2019/12 - Atual Vice-Coordinator of the i3S Integrative Program on Neurobiology and Neurologic Disorders. Member of the i3S Restricted Scientific Committee Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2019 Scientific Coordinator of the Bioimage Analysis Platform at INEB Instituto Nacional de Engenharia Biomédica, Portugal


Categoria Profissional
Instituição de acolhimento
2014 - Atual Affiliate Professor (Biophysics) Universidade do Porto Faculdade de Medicina, Portugal


Designação Financiadores
2023/01/01 - 2025/12/31 smartDBS - Improving Deep Brain Stimulation in Parkinson’s Disease with Personalized Electrophysiological Biomarkers and Data-Driven Stimulation
Prémio Mantero Belard, MB-12-22
Investigador responsável
Santa Casa da Misericórdia de Lisboa
2022/12/31 - 2025/12/30 NeuroSpark - Neuromorphic devices for adaptive real-time neuromodulation in brain electrical stimulation therapies
Investigador responsável
Obra Social La Caixa
2022/01/01 - 2024/12/31 Storing and recalling biological Memories with Neuromorphic Electronics
Fundação para a Ciência e a Tecnologia
2021 - 2024 Spatiotemporal dissection of nuclear mechanics in the maintenance of chromosomal stability
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2023/06/30 Dissecting the mechanisms underlying tension-driven axon growth.
Fundação para a Ciência e a Tecnologia
2019 - 2022 Mind The Gap: decoding and bridging somatosensory information in the spinal cord
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 NIMAS - New Active Medical Implants
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 ACTinRING - Uncovering the mechanistic assembly and function of actin ring networks in axonal biology and pathology
Fundação para a Ciência e a Tecnologia
Em curso
2016 - 2019 Combinatorial regenerative strategy to potentiate axon regeneration and improve functional recovery after spinal cord injury
Prémio Melo e Castro
Santa Casa da Misericórdia de Lisboa
2017 - 2018 Facegram - a new standard and a universal tool for detailed analysis of facial movements in the context of therapy, surgery and rehabilitation of the face
Investigador responsável
Comissao de Coordenacao e Desenvolvimento Regional do Norte
2017 - 2018 mCBEEs - Advanced integrative solutions to Corrosion problems beyond micro–scale: towards long-term durability of miniaturized Biomedical, Electronic and Energy systems
Marie Sklodowska-Curie grant agreement No 764977
European Commission Marie Sklodowska-Curie Actions
2016 - 2018 Spatiotemporal control of mitotic spindle assembly
Fundação para a Ciência e a Tecnologia
2016 - 2018 Biodegradable dendrimers for targeted neuroprotective therapies in stroke
Fundação para a Ciência e a Tecnologia
2016 - 2018 Sensory innervation in the complex orchestration of bone regeneration: interplay in microfluidics platforms
Fundação para a Ciência e a Tecnologia
2016 - 2018 Hybrid neuron-memristor adaptive platform (NeuronMAP)
Fundação para a Ciência e a Tecnologia
2016 - 2018 NEUBIAS: Network of European BioImage Analysts
COST Action CA15124
European Cooperation in Science and Technology
2014 - 2018 Memristors - Devices, Models, Circuits, Systems and Applications (MemoCiS)
COST Action IC1401
European Cooperation in Science and Technology
2013/04 - 2015/04 Y1 receptor based therapy for local bone repair: Antagonist behavior and delivery in challenged bone microenvironment
Ministério da Ciência Tecnologia e Ensino Superior
2012/04 - 2015/03 Memristor Based Adaptive Neural Networks (MemBrAiNN)
Fundação para a Ciência e a Tecnologia
2007/07 - 2010/06 Theoretical models of nociceptive information processing and transmission in the spinal cord´s dorsal horn.
Investigador responsável
Ministério da Ciência Tecnologia e Ensino Superior
2000/09/01 - 2001/07/31 Study of Type Ia supernovae and their cosmological implications
Bolseiro de Doutoramento
Instituto Superior Técnico Departamento de Física, Portugal
Fundação para a Ciência e a Tecnologia


Artigo em conferência
  1. Monteiro, J.P.; Oliveira, H.P.; Aguiar, P.; Cardoso, J.S.. "A depth-map approach for automatic mice behavior recognition". 2014.
  2. Aguiar, P.; David, A.; Paulo, S.; Rosa, A.. "EEGSolver - Brain activity and genetic algorithms". 2000.
Artigo em revista
  1. Margarida Dantas; Andreia Oliveira; Paulo Aguiar; Helder Maiato; Jorge G. Ferreira. "Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation". Journal of Cell Biology (2022): https://doi.org/10.1083/jcb.202205051.
  2. Eduardo Conde-Sousa; João Vale; Ming Feng; KELE XU; Yin Wang; Della Mea V; David La Barbera; et al. "HEROHE Challenge: Predicting HER2 Status in Breast Cancer from Hematoxylin–Eosin Whole-Slide Imaging". Journal of Imaging (2022): https://www.mdpi.com/2313-433X/8/8/213.
  3. Ana C. Almeida; Joana Soares-de-Oliveira; Danica Drpic; Liam P. Cheeseman; Joana Damas; Harris A. Lewin; Denis M. Larkin; et al. "Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals". Cell Reports (2022): https://doi.org/10.1016/j.celrep.2022.110610.
  4. Urša Blenkuš; Ana Filipa Gerós; Cristiana Carpinteiro; Paulo de Castro Aguiar; I. Anna S. Olsson; Nuno Henrique Franco. "Non-Invasive Assessment of Mild Stress-Induced Hyperthermia by Infrared Thermography in Laboratory Mice". Animals (2022): https://doi.org/10.3390/ani12020177.
  5. Mateus, J.C.; Weaver, S.; Van Swaay, D.; Renz, A.F.; Hengsteler, J.; Aguiar, P.; Vörös, J.. "Nanoscale Patterning of in Vitro Neuronal Circuits". ACS Nano 16 4 (2022): 5731-5742. http://www.scopus.com/inward/record.url?eid=2-s2.0-85129103498&partnerID=MN8TOARS.
  6. Dias, C.; Castro, D.; Aroso, M.; Ventura, J.; Aguiar, P.. "Memristor-Based Neuromodulation Device for Real-Time Monitoring and Adaptive Control of Neuronal Populations". ACS Applied Electronic Materials (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130149541&partnerID=MN8TOARS.
  7. Mateus, JC; Lopes, CDF; Aroso, M; Costa, AR; Gerós, A; Meneses, J; Faria, P; et al. "Bidirectional flow of action potentials in axons drives activity dynamics in neuronal cultures". Journal of Neural Engineering 18 6 (2021): 066045. http://dx.doi.org/10.1088/1741-2552/ac41db.
  8. Teixeira, H.; Dias, C.; Aguiar, P.; Ventura, J.. "Gold-Mushroom Microelectrode Arrays and the Quest for Intracellular-Like Recordings: Perspectives and Outlooks". Advanced Materials Technologies 6 2 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85097519751&partnerID=MN8TOARS.
  9. Polónia, António; Campelos, Sofia; Ribeiro, Ana; Aymore, Ierece; Pinto, Daniel; Biskup-Fruzynska, Magdalena; Veiga, Ricardo Santana; et al. "Artificial Intelligence Improves the Accuracy in Histologic Classification of Breast Lesions". American Journal of Clinical Pathology 155 4 (2020): 527-536. http://dx.doi.org/10.1093/ajcp/aqaa151.
  10. Ana Gerós; Ana Magalhães; Paulo Aguiar. "Improved 3D tracking and automated classification of rodents’ behavioral activity using depth-sensing cameras". Behavior Research Methods (2020): https://doi.org/10.3758/s13428-020-01381-9.
  11. Loureiro, J.; Torres, A.L.; Neto, T.; Aguiar, P.; Barrias, C.C.; Pinto, M.T.; Amaral, I.F.. "Corrigendum to “Conjugation of the T1 sequence from CCN1 to fibrin hydrogels for therapeutic vascularization” [Mater. Sci. & Eng. C. 104 (2019) 109847](S092849311930548X)(10.1016/j.msec.2019.109847)". Materials Science and Engineering C 108 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076046977&partnerID=MN8TOARS.
  12. Costa, A.R.; Sousa, S.C.; Pinto-Costa, R.; Mateus, J.C.; Lopes, C.D.; Costa, A.C.; Rosa, D.; et al. "The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction". eLife 9 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082635132&partnerID=MN8TOARS.
  13. Nunes, V.; Dantas, M.; Castro, D.; Vitiello, E.; Wang, I.; Carpi, N.; Balland, M.; et al. "Centrosome-nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity". Molecular Biology of the Cell 31 16 (2020): 1675-1690. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088608180&partnerID=MN8TOARS.
  14. Castro, D.; Nunes, V.; Lima, J.T.; Ferreira, J.G.; Aguiar, P.. "Trackosome: a computational toolbox to study the spatiotemporal dynamics of centrosomes, nuclear envelope and cellular membrane". Journal of Cell Science 133 24 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099992997&partnerID=MN8TOARS.
  15. Kristine Heiney; José C. Mateus; Cátia D. F. Lopes; Estrela Neto; Meriem Lamghari; Paulo Aguiar. "µSpikeHunter: An advanced computational tool for the analysis of neuronal communication and action potential propagation in microfluidic platforms". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-42148-3.
  16. José C Mateus; Cátia D F Lopes; Mónica Cerquido; Luís Leitão; Diana Leitão; Susana Cardoso; João Ventura; Paulo Aguiar. "Improved in vitro electrophysiology using 3D-structured microelectrode arrays with a micro-mushrooms islets architecture capable of promoting topotaxis". Journal of Neural Engineering (2019): https://doi.org/10.1088/1741-2552/ab0b86.
  17. Franco, N.H.; Gerós, A.; Oliveira, L.; Olsson, I.A.S.; Aguiar, P.. "ThermoLabAnimal - A high-throughput analysis software for non-invasive thermal assessment of laboratory mice". Physiology and Behavior 207 (2019): 113-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065609959&partnerID=MN8TOARS.
  18. Aresta, G.; Araújo, T.; Kwok, S.; Chennamsetty, S.S.; Safwan, M.; Alex, V.; Marami, B.; et al. "BACH: Grand challenge on breast cancer histology images". Medical Image Analysis 56 (2019): 122-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067343074&partnerID=MN8TOARS.
  19. Leitão, L.; Alves, C.J.; Alencastre, I.S.; Sousa, D.M.; Neto, E.; Conceição, F.; Leitão, C.; et al. "Bone marrow cell response after injury and during early stage of regeneration is independent of the tissue-of-injury in 2 injury models". FASEB Journal 33 1 (2019): 857-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059244844&partnerID=MN8TOARS.
  20. Loureiro, J.; Torres, A.L.; Neto, T.; Aguiar, P.; Barrias, C.C.; Pinto, M.T.; Amaral, I.F.. "Conjugation of the T1 sequence from CCN1 to fibrin hydrogels for therapeutic vascularization". Materials Science and Engineering C 104 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068767347&partnerID=MN8TOARS.
  21. Catarina Dias; Luís M. Guerra; Paulo Aguiar; João Ventura. "The Concept of Metal-Insulator-Metal Nanostructures as Adaptive Neural Networks". U.Porto Journal of Engineering (2018): https://doi.org/10.24840/2183-6493_003.001_0001.
  22. Fondón, I.; Sarmiento, A.; García, A.I.; Silvestre, M.; Eloy, C.; Polónia, A.; Aguiar, P.. "Automatic classification of tissue malignancy for breast carcinoma diagnosis". Computers in Biology and Medicine 96 (2018): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043461026&partnerID=MN8TOARS.
  23. Horta, R.; Nascimento, R.; Gerós, A.; Aguiar, P.; Silva, A.; Amarante, J.. "A Novel System for Assessing Facial Muscle Movements: The Facegram 3D". Surgical Innovation 25 1 (2018): 90-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040841966&partnerID=MN8TOARS.
  24. Lopes, C.D.F.; Mateus, J.C.; Aguiar, P.. "Interfacing microfluidics with microelectrode arrays for studying neuronal communication and axonal signal propagation". Journal of Visualized Experiments 2018 142 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058915521&partnerID=MN8TOARS.
  25. Cerquido, M.; Proenca, M.P.; Dias, C.; Leitao, D.C.; Cardoso, S.; Freitas, P.P.; Aguiar, P.; Ventura, J.. "Tailoring the cap's morphology of electrodeposited gold micro-mushrooms". Applied Surface Science 445 (2018): 512-518. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044588454&partnerID=MN8TOARS.
  26. Drpic, D.; Almeida, A.C.; Aguiar, P.; Renda, F.; Damas, J.; Lewin, H.A.; Larkin, D.M.; Khodjakov, A.; Maiato, H.. "Chromosome Segregation Is Biased by Kinetochore Size". Current Biology 28 9 (2018): 1344-1356.e5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045880247&partnerID=MN8TOARS.
  27. Torres, A.L.; Bidarra, S.J.; Pinto, M.T.; Aguiar, P.C.; Silva, E.A.; Barrias, C.C.. "Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis". Biomaterials 154 (2018): 34-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032820887&partnerID=MN8TOARS.
  28. Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D.. "Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021292472&partnerID=MN8TOARS.
  29. Mestre, A.L.G.; Inácio, P.M.C.; Elamine, Y.; Asgarifar, S.; Lourenço, A.S.; Cristiano, M.L.S.; Aguiar, P.; et al. "Extracellular electrophysiological measurements of cooperative signals in astrocytes populations". Frontiers in Neural Circuits 11 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85032285952&partnerID=MN8TOARS.
  30. Mestre, A.L.G.; Cerquido, M.; Inácio, P.M.C.; Asgarifar, S.; Lourenço, A.S.; Cristiano, M.L.S.; Aguiar, P.; et al. "Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85032462728&partnerID=MN8TOARS.
  31. Shamarova, E.; Chertovskih, R.; Ramos, A.F.; Aguiar, P.. "Backward-stochastic-differential-equation approach to modeling of gene expression". Physical Review E 95 3 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016463242&partnerID=MN8TOARS.
  32. Conde-Sousa, E.; Szücs, P.; Peng, H.; Aguiar, P.. "N3DFix: an Algorithm for Automatic Removal of Swelling Artifacts in Neuronal Reconstructions". Neuroinformatics 15 1 (2017): 5-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978143735&partnerID=MN8TOARS.
  33. Dias, C.; Lv, H.; Picos, R.; Aguiar, P.; Cardoso, S.; Freitas, P.P.; Ventura, J.. "Bipolar resistive switching in Si/Ag nanostructures". Applied Surface Science 424 (2017): 122-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013683491&partnerID=MN8TOARS.
  34. Araujo, T.; Aresta, G.; Castro, E.; Rouco, J.; Aguiar, P.; Eloy, C.; Polonia, A.; Campilho, A.. "Classification of breast cancer histology images using convolutional neural networks". PLoS ONE 12 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020032538&partnerID=MN8TOARS.
  35. Teixeira, G.Q.; Leite Pereira, C.; Castro, F.; Ferreira, J.R.; Gomez-Lazaro, M.; Aguiar, P.; Barbosa, M.A.; Neidlinger-Wilke, C.; Goncalves, R.M.. "Anti-inflammatory Chitosan/Poly-¿-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc". Acta Biomaterialia 42 (2016): 168-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983262266&partnerID=MN8TOARS.
  36. Sousa, D.M.; Conceição, F.; Silva, D.I.; Leitão, L.; Neto, E.; Alves, C.J.; Alencastre, I.S.; et al. "Ablation of Y1 receptor impairs osteoclast bone-resorbing activity". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988625216&partnerID=MN8TOARS.
  37. Gerós, A.; Horta, R.; Aguiar, P.. "Facegram - Objective quantitative analysis in facial reconstructive surgery". Journal of Biomedical Informatics 61 (2016): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961616824&partnerID=MN8TOARS.
  38. Alencastre, I.S.; Sousa, D.M.; Alves, C.J.; Leit�o, L.; Neto, E.; Aguiar, P.; Lamghari, M.. "Delivery of pharmaceutics to bone: Nanotechnologies, high-throughput processing and in silico mathematical models". European Cells and Materials 31 (2016): 355-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973639341&partnerID=MN8TOARS.
  39. Lopes, C.D.F.; Gomes, C.P.; Neto, E.; Sampaio, P.; Aguiar, P.; Pêgo, A.P.. "Microfluidic-based platform to mimic the in vivo peripheral administration of neurotropic nanoparticles". Nanomedicine 11 24 (2016): 3205-3221. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998705753&partnerID=MN8TOARS.
  40. Pereira, A.J.; Aguiar, P.; Belsley, M.; Maiato, H.. "Inducible fluorescent speckle microscopy". Journal of Cell Biology 212 2 (2016): 245-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959490543&partnerID=MN8TOARS.
  41. Neto, E.; Leitão, L.; Sousa, D.M.; Alves, C.J.; Alencastre, I.S.; Aguiar, P.; Lamghari, M.. "Compartmentalized microfluidic platforms: The unrivaled breakthrough of in vitro tools for neurobiological research". Journal of Neuroscience 36 46 (2016): 11573-11584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996552043&partnerID=MN8TOARS.
  42. Pereira, C.L.; Teixeira, G.Q.; Ribeiro-Machado, C.; Caldeira, J.; Costa, M.; Figueiredo, F.; Fernandes, R.; et al. "Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988672665&partnerID=MN8TOARS.
  43. Dias, C.; Guerra, L.M.; Ventura, J.; Aguiar, P.. "Memristor-based Willshaw network: Capacity and robustness to noise in the presence of defects". Applied Physics Letters 106 22 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930960301&partnerID=MN8TOARS.
  44. Silva, P.; Aguiar, P.; Duarte, R.; Davids, K.; Araújo, D.; Garganta, J.. "Effects of pitch size and skill level on tactical behaviours of association football players during small-sided and conditioned games". International Journal of Sports Science and Coaching 9 5 (2014): 993-1006. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919760822&partnerID=MN8TOARS.
  45. Silva, P.; Travassos, B.; Vilar, L.; Aguiar, P.; Davids, K.; Araújo, D.; Garganta, J.. "Numerical relations and skill level constrain co-adaptive behaviors of agents in sports teams". PLoS ONE 9 9 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84906991508&partnerID=MN8TOARS.
  46. Silva, P.; Duarte, R.; Sampaio, J.; Aguiar, P.; Davids, K.; Araújo, D.; Garganta, J.. "Field dimension and skill level constrain team tactical behaviours in small-sided and conditioned games in football". Journal of Sports Sciences 32 20 (2014): 1888-1896. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918836662&partnerID=MN8TOARS.
  47. Horta, R.; Aguiar, P.; Silva, P.; Monteiro, D.; Amarante, J.M.. "Facial disfigurement: Restoration of facial dynamics in a patient with concomitant facial paralysis and blindness". Journal of Reconstructive Microsurgery 30 3 (2014): 207-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896695594&partnerID=MN8TOARS.
  48. Afonso, O.; Matos, I.; Pereira, A.J.; Aguiar, P.; Lampson, M.A.; Maiato, H.. "Feedback control of chromosome separation by a midzone Aurora B gradient". Science 345 6194 (2014): 332-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904382634&partnerID=MN8TOARS.
  49. Sousa, M.; Szucs, P.; Lima, D.; Aguiar, P.. "The pronociceptive dorsal reticular nucleus contains mostly tonic neurons and shows a high prevalence of spontaneous activity in block preparation". Journal of Neurophysiology 111 7 (2014): 1507-1518. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900810824&partnerID=MN8TOARS.
  50. Sousa, M.; Aguiar, P.. "Building, simulating and visualizing large spiking neural networks with NeuralSyns". Neurocomputing 123 (2014): 372-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885844080&partnerID=MN8TOARS.
  51. Castro, L.; Aguiar, P.. "A feedforward model for the formation of a grid field where spatial information is provided solely from place cells". Biological Cybernetics 108 2 (2014): 133-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898883716&partnerID=MN8TOARS.
  52. Horta, R.; Aguiar, P.; Monteiro, D.; Silva, A.; Amarante, J.M.. "A facegram for spatial-temporal analysis of facial excursion: Applicability in the microsurgical reanimation of long-standing paralysis and pretransplantation". Journal of Cranio-Maxillofacial Surgery 42 7 (2014): 1250-1259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908230161&partnerID=MN8TOARS.
  53. Barisic, M.; Aguiar, P.; Geley, S.; Maiato, H.. "Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces". Nature Cell Biology 16 12 (2014): 1249-1256. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925285786&partnerID=MN8TOARS.
  54. Neto, E.; Alves, C.J.; Sousa, D.M.; Alencastre, I.S.; Lourenço, A.H.; Leitão, L.; Ryu, H.R.; et al. "Sensory neurons and osteoblasts: Close partners in a microfluidic platform". Integrative Biology (United Kingdom) 6 6 (2014): 586-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901624359&partnerID=MN8TOARS.
  55. Conde-Sousa, E.; Aguiar, P.. "A working memory model for serial order that stores information in the intrinsic excitability properties of neurons". Journal of Computational Neuroscience 35 2 (2013): 187-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883784747&partnerID=MN8TOARS.
  56. Moutinho-Pereira, S.; Stuurman, N.; Afonso, O.; Hornsveld, M.; Aguiar, P.; Goshima, G.; Vale, R.D.; Maiato, H.. "Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells". Proceedings of the National Academy of Sciences of the United States of America 110 49 (2013): 19808-19813. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889661951&partnerID=MN8TOARS.
  57. Horta, R.; Monteiro, D.; Silva, A.; Amarante, J.M.; Aguiar, P.. "Erratum: Evaluation of a facial transplant candidate with a facegram: A baseline analysis (Plastic and Reconstructive Surgery (2013) 132 (479e-480))". Plastic and Reconstructive Surgery 132 4 (2013): 1040-1041. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885454603&partnerID=MN8TOARS.
  58. Szucs, P.; Luz, L.L.; Pinho, R.; Aguiar, P.; Antal, Z.; Tiong, S.Y.X.; Todd, A.J.; Safronov, B.V.. "Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord". Journal of Comparative Neurology 521 12 (2013): 2719-2741. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879484866&partnerID=MN8TOARS.
  59. Aguiar, P.; Horta, R.; Monteiro, D.; Silva, A.; Amarante, J.M.. "Evaluation of a facial transplant candidate with a facegram: A baseline analysis". Plastic and Reconstructive Surgery 132 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883574434&partnerID=MN8TOARS.
  60. Aguiar, P.; Sousa, M.; Szucs, P.. "Versatile morphometric analysis and visualization of the three-dimensional structure of neurons". Neuroinformatics 11 4 (2013): 393-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886291005&partnerID=MN8TOARS.
  61. Carneiro, J.; Duarte-Pereira, S.; Azevedo, L.; Castro, L.F.C.; Aguiar, P.; Moreira, I.S.; Amorim, A.; Silva, R.M.. "The Evolutionary Portrait of Metazoan NAD Salvage". PLoS ONE 8 5 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84878391235&partnerID=MN8TOARS.
  62. Silva, P.; Garganta, J.; Araújo, D.; Davids, K.; Aguiar, P.. "Shared knowledge or shared affordances? insights from an ecological dynamics approach to team coordination in sports". Sports Medicine 43 9 (2013): 765-772. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883221144&partnerID=MN8TOARS.
  63. Guimarães, J.; Moura, E.; Silva, E.; Aguiar, P.; Garrett, C.; Vieira-Coelho, M.A.. "Locus coeruleus is involved in weight loss in a rat model of Parkinson's disease: An effect reversed by deep brain stimulation". Brain Stimulation 6 6 (2013): 845-855. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887990923&partnerID=MN8TOARS.
  64. Castro, L.; Aguiar, P.. "Phase precession through acceleration of local theta rhythm: A biophysical model for the interaction between place cells and local inhibitory neurons". Journal of Computational Neuroscience 33 1 (2012): 141-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861878587&partnerID=MN8TOARS.
  65. Pinto, S.; Krishna, R.; Dias, C.; Pimentel, G.; Oliveira, G.N.P.; Teixeira, J.M.; Aguiar, P.; et al. "Resistive switching and activity-dependent modifications in Ni-doped graphene oxide thin films". Applied Physics Letters 101 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865141673&partnerID=MN8TOARS.
  66. Pais-Vieira, M.; Aguiar, P.; Lima, D.; Galhardo, V.. "Inflammatory pain disrupts the orbitofrontal neuronal activity and risk-assessment performance in a rodent decision-making task". Pain 153 8 (2012): 1625-1635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863720383&partnerID=MN8TOARS.
  67. Aguiar, P.; Sousa, M.; Lima, D.. "NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons". Journal of Neurophysiology 104 2 (2010): 1155-1166. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955972258&partnerID=MN8TOARS.
  68. Vourvouhaki, E.; Carvalho, C.; Aguiar, P.. "Model for Osteosarcoma-9 as a potent factor in cell survival and resistance to apoptosis". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 76 1 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547619785&partnerID=MN8TOARS.
  69. Aguiar, P.; Mendonça, L.; Galhardo, V.. "OpenControl: A free opensource software for video tracking and automated control of behavioral mazes". Journal of Neuroscience Methods 166 1 (2007): 66-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548491369&partnerID=MN8TOARS.
  70. Aguiar, P.; Willshaw, D.. "Hippocampal mossy fibre boutons as dynamical synapses". Neurocomputing 58-60 (2004): 699-703. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542481831&partnerID=MN8TOARS.
Capítulo de livro
  1. Dias, C.; Silva, D.J.; Aguiar, P.; Ventura, J.. "Associative networks and perceptron based on memristors: Fundamentals and algorithmic implementation". 729-765. 2019.
  2. Dias, C.; Ventura, J.; Aguiar, P.. "Memristive-based neuromorphic applications and associative memories". 2017.
  3. Neto, E.; Paramos-De-Carvalho, D.; Lourenço, A.H.; Aguiar, P.; Lamghari, M.. "Compartmentalized microfluidic platforms as tool of choice to study the interaction between neurons and osteoblasts". 2015.
  1. Domingos Leite de Castro; Miguel Aroso; A. Pedro Aguiar; David B. Grayden; Paulo Aguiar. "Adaptive delayed feedback control disrupts unwanted neuronal oscillations and adjusts to network synchronization dynamics". Pré-impressão. 2022. https://doi.org/10.1101/2022.07.05.498735.
  2. Ana Gerós; Ricardo Cruz; Fabrice de Chaumont; Jaime S. Cardoso; Paulo Aguiar. "Deep learning-based system for real-time behavior recognition and closed-loop control of behavioral mazes using depth sensing". Pré-impressão. 2022. https://doi.org/10.1101/2022.02.22.481410.
  3. José C. Mateus; Sean Weaver; Dirk van Swaay; Aline F. Renz; Julian Hengsteler; Paulo Aguiar; János Vörös. "Nanoscale patterning of in vitro neuronal circuits". Pré-impressão. 2021. https://doi.org/10.1101/2021.12.16.472887.
  4. Margarida Dantas; Andreia Oliveira; Paulo Aguiar; Helder Maiato; Jorge G. Ferreira. "Mechanosensitive control of mitotic entry". Pré-impressão. 2021. https://doi.org/10.1101/2021.09.23.461473.


Conjunto de dados
  1. BACH Dataset : Grand Challenge on Breast Cancer Histology images.
  2. RGB-D Rat Behavioral Dataset.
Outra produção
  1. A memristor-based neuromodulation device for real-time monitoring and adaptive control of in vitro neuronal populations. 2021. Catarina Dias; Domingos Castro; Miguel Aroso; João Ventura; Paulo Aguiar. https://doi.org/10.1101/2021.05.20.444941.
  2. In vitro neuronal networks show bidirectional axonal conduction with antidromic action potentials effectively depolarizing the soma. 2021. Mateus, J.C.; Lopes, C.D.F.; Aroso, M.; Costa, A.R.; Gerós, A.; Pereira, A.; Meneses, J.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105400648&partnerID=MN8TOARS.
  3. Kinetochore-mediated microtubule assembly and Augmin-dependent amplification drive k-fiber maturation in mammals. 2021. Almeida, A.C.; Oliveira, J.; Drpic, D.; Cheeseman, L.P.; Damas, J.; Lewin, H.A.; Larkin, D.M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118903356&partnerID=MN8TOARS.
  4. HEROHE Challenge: Assessing HER2 status in breast cancer without immunohistochemistry or in situ hybridization. 2021. Conde-Sousa, E.; Vale, J.; Feng, M.; Xu, K.; Wang, Y.; Mea, V.D.; Barbera, D.L.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85119863671&partnerID=MN8TOARS.
  5. Mechanosensitive nuclear asymmetries define a bipolar spindle scaffold to ensure mitotic fidelity. 2019. Nunes, V.; Dantas, M.; Castro, D.; Vitiello, E.; Wang, I.; Carpi, N.; Balland, M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095641297&partnerID=MN8TOARS.
  6. Sensory neurons sprouting is dependent on osteoclast-derived extracellular vesicles involving the activation of epidermal growth factor receptors. 2018. Estrela Neto; Luís Leitão; José Mateus; Daniela M. Sousa; Francisco Conceição; Cecília J. Alves; Richard O. C. Oreffo; et al. https://doi.org/10.1101/259218.
  7. Chromosome (mis)segregation is biased by kinetochore size. 2018. Drpic, D.; Almeida, A.; Aguiar, P.; Maiato, H.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095639270&partnerID=MN8TOARS.
  8. µSpikeHunter: An advanced computational tool for the analysis of neuronal communication and action potential propagation in microfluidic platforms. 2018. Heiney, K.; Mateus, J.; Lopes, C.; Neto, E.; Lamghari, M.; Aguiar, P.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85094440449&partnerID=MN8TOARS.

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2017 - Atual Workshop on Neuroengineering (2017)
Oficina (workshop) (Presidente da Comissão Organizadora)
2018 - 2019 Future of Computing (2018 - 2019)
Oficina (workshop) (Coorganizador)
2014 - 2016 International Symposium in Applied Bioimaging (2014 - 2016)
Simpósio (Coorganizador)

Júri de grau académico

Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2019 Transcutaneous spinal direct current stimulation: modelling the spinal electric field distribution and clinical relevance
Sofia Rita Fernandes (Doutoramento)
Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal
2016 LocoMouse: a novel system for studying the role of cerebellum in gait coordination
Ana Sofia Rodrigues Machado (Doutoramento)
2014 Multi-bump solutions in dynamic neural fields: Analysis and Applications
Arguente principal
Flora Ferreira (Doutoramento)
2014 Efficient storage and retrieval of memories in neural networks
Arguente principal
João Sacramento (Doutoramento)
Instituto Superior Técnico Departamento de Física, Portugal
2009 Numerical modelling in Transcranial Magnetic Stimulation
Arguente principal
Ricardo Salvador (Doutoramento)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020 - Atual Introduction to Python and Fundamental Concepts in Machine Learning (Outros) Universidade do Porto, Portugal
2017 - Atual Neuroengineering (Mestrado integrado) Universidade do Porto Faculdade de Engenharia, Portugal
2010 - 2020 Introduction to Scientific Programming with MATLAB (Outros)
2016 - 2018 NEUBIAS - International school on bioimage analysis
2014 - 2018 Medical Biophysics (Mestrado integrado)
2016 - 2017 CAJAL Course in Computational Neuroscience Programa Champalimaud de Neurociências, Portugal
2008 - 2017 Computational Neuroscience (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2012 Mathematics in Biology; Computational Biology (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2002 - 2004 Teaching Assistant (in M.Sc. courses): 1) "Neural Computation"; 2) "Learning from Data"; 3) "Maths Refresher" (Master) The University of Edinburgh Institute for Adaptive and Neural Computation, Reino Unido
1998 - 2000 Teaching Assistant (in B.Sc. courses): 1) "Physics II"; 2) "Computational Physics" (Bacharelato)

Membro de associação

Nome da associação Tipo de participação
2006 - Atual Sociedade Portuguesa de Neurociências
1999 - 2000 NFIST Astronomy Group Director

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2019 - Atual Vice-Coordinator of the Neurobiology and Neurologic Disorders (NDD) Integrative Program at i3S
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2000 - 2001 IST Physics Degree Committee (only non-Professor member)