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Paulo Aguiar graduated in Physics ("Engª Física Tecnológica") from Instituto Superior Técnico, University of Lisbon, Portugal, and completed the course work in the Biophysics Doctoral Program at the Institute for Biophysics and Biomedical Engineering, University of Lisbon in 2001 (final grade 95/100, among the highest achieved in the program). He then moved to the United Kingdom to continue his studies at the Institute for Adaptive and Neural Computation, University of Edinburgh. After finishing his PhD in Computational Neuroscience (U. Edinburgh, 2006) he joined, as a postdoc in neurobiology, the Neuroscience Unit at the Institute for Molecular and Cellular Biology, Portugal. In 2008 he was awarded a competitive researcher grant in Computational Biology, and in 2013 he was invited to join the National Institute for Biomedical Engineering (INEB) as an Assistant Investigator. Since 2016 he is a Principal Investigator at the Institute for Research and Innovation in Health (i3S), the largest R&D institution for health sciences research in Portugal, where he leads the Neuroengineering and Computational Neuroscience Lab (NCN). Sign of his scientific recognition, he was elected Vice-Coordinator of the Neurobiology and Neurologic Disorders Research Program at i3S, for the period 2019-2023 (harboring 23 research groups). He is also invited Associate Prof. at ICBAS, invited Associate Prof. in Neuroengineering at Faculty of Engineering, and Affiliate Prof. in Biophysics at Faculty of Medicine, all at Univ. of Porto. He has been responsible for several courses in physics, mathematics, neurobiology and engineering, and has received a Univ. of Porto Pedagogical Score of 6.7/7.0 by the students. He has supervised and co-supervised 16 PhD students (completed + ongoing). Paulo Aguiar is author in 75+ international peer-reviewed publications (including in Science, Nature Cell Biology, Nature Methods, J. Neuroscience, eLife, PNAS, J. Neural Eng., Medical Image Analysis; over 5100 citations). He has been already (co)PI/Task Leader in 18 national and international research projects, obtained in competitive calls.
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Identification

Personal identification

Full name
Paulo de Castro Aguiar

Citation names

  • Aguiar, Paulo

Author identifiers

Ciência ID
0413-0808-A59C
ORCID iD
0000-0003-4164-5713
Google Scholar ID
Jwr9SgMAAAAJ
Scopus Author Id
36842157600

Email addresses

  • pauloaguiar@i3s.up.pt (Professional)

Telephones

Telephone
  • 220408800 (Professional)

Addresses

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Medical Engineering
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Biophysics
  • Exact Sciences - Computer and Information Sciences - Information Science
  • Exact Sciences - Computer and Information Sciences - Computer Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Intermediate (B1) Intermediate (B1) Beginner (A1)
Japanese Beginner (A1) Beginner (A1)
Education
Degree Classification
2006/06/21
Concluded
 PhD (Doctor of Philosophy)
The University of Edinburgh Institute for Adaptive and Neural Computation, United Kingdom
"A General Hippocampal Computational Model: Episodic and Spatial Memory Combined in a Spiking Model" (THESIS/DISSERTATION)
2003/08/01 - 2003/08/31
Concluded
 Advanced Course in Computational Neuroscience (Outros)
IBRO - International Brain Research Organization, France
2001/07/31
Concluded
 Doctoral Training Program in Biophysics and Biomedical Engineering (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal
 19/20
1995/09/01 - 2000/07/31
Concluded
 Engenharia Física Tecnológica (Mestrado integrado)
Instituto Superior Técnico Departamento de Física, Portugal
 16/20
Affiliation

Science

Category
Host institution 		Employer
2016/11/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/05/02 - 2016/10/31 Auxiliary Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2015/02/01 - 2015/02/15 Visiting Researcher (Research) Universiteit Antwerpen Campus Drie Eiken, Belgium
2008/05/02 - 2013/05/01 Auxiliary Researcher (Research) Universidade do Porto Faculdade de Ciências, Portugal
2006/06/22 - 2008/05/01 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2017 - Current Invited Associate Professor (University Teacher) Universidade do Porto Faculdade de Engenharia, Portugal
2021/01 - 2022 Invited Associate Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Positions / Appointments

Category
Host institution 		Employer
2019/12 - 2023/12 Vice-Coordinator of the i3S Integrative Program on Neurobiology and Neurologic Disorders. Member of the i3S Restricted Scientific Committee Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2019 Scientific Coordinator of the Bioimage Analysis Platform at INEB Instituto Nacional de Engenharia Biomédica, Portugal

Others

Category
Host institution 		Employer
2014 - Current Affiliate Professor (Biophysics) Universidade do Porto Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2025/01/02 - 2026/07/01 Establishing humanized Brain-on-a-Chip devices for the study of Activity-dependent neuronal Development
2023.11280.PEX
10.54499/2023.11280.PEX
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2025/12/31 smartDBS - Improving Deep Brain Stimulation in Parkinson’s Disease with Personalized Electrophysiological Biomarkers and Data-Driven Stimulation
Prémio Mantero Belard, MB-12-22
Principal investigator
Santa Casa da Misericórdia de Lisboa
2022/12/31 - 2025/12/30 NeuroSpark - Neuromorphic devices for adaptive real-time neuromodulation in brain electrical stimulation therapies
HR22-00189
Principal investigator
Obra Social La Caixa
2022/01/01 - 2024/12/31 Storing and recalling biological Memories with Neuromorphic Electronics
PTDC/NAN-MAT/4093/2021
Researcher
Fundação para a Ciência e a Tecnologia
2021 - 2024 Spatiotemporal dissection of nuclear mechanics in the maintenance of chromosomal stability
PTDC/BIA-CEL/6740/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/06/30 Dissecting the mechanisms underlying tension-driven axon growth.
EXPL/BIA-CEL/0717/2021
Researcher
Fundação para a Ciência e a Tecnologia
2019 - 2022 Mind The Gap: decoding and bridging somatosensory information in the spinal cord
PTDC/EMD-EMD/31540/2017
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 NIMAS - New Active Medical Implants
PTDC/EEI-EEE/32348/2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 ACTinRING - Uncovering the mechanistic assembly and function of actin ring networks in axonal biology and pathology
02/SAICT/2017/28623
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2019 Combinatorial regenerative strategy to potentiate axon regeneration and improve functional recovery after spinal cord injury
Prémio Melo e Castro
Researcher
Santa Casa da Misericórdia de Lisboa
Concluded
2017 - 2018 Facegram - a new standard and a universal tool for detailed analysis of facial movements in the context of therapy, surgery and rehabilitation of the face
FACEGRAM
Principal investigator
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded
2017 - 2018 mCBEEs - Advanced integrative solutions to Corrosion problems beyond micro–scale: towards long-term durability of miniaturized Biomedical, Electronic and Energy systems
Marie Sklodowska-Curie grant agreement No 764977
Researcher
European Commission Marie Sklodowska-Curie Actions
2016 - 2018 Spatiotemporal control of mitotic spindle assembly
PTDC/BEX-BCM/1758/2014
Researcher
Fundação para a Ciência e a Tecnologia
2016 - 2018 Biodegradable dendrimers for targeted neuroprotective therapies in stroke
PTDC/CTM-NAN/3547/2014
Researcher
Fundação para a Ciência e a Tecnologia
2016 - 2018 Sensory innervation in the complex orchestration of bone regeneration: interplay in microfluidics platforms
PTDC/BIM-MED/4041/2014
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2018 Hybrid neuron-memristor adaptive platform (NeuronMAP)
PTDC/CTM-NAN/3146/2014
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2018 NEUBIAS: Network of European BioImage Analysts
COST Action CA15124
Researcher
European Cooperation in Science and Technology
Concluded
2014 - 2018 Memristors - Devices, Models, Circuits, Systems and Applications (MemoCiS)
COST Action IC1401
Researcher
European Cooperation in Science and Technology
Concluded
2013/04 - 2015/04 Y1 receptor based therapy for local bone repair: Antagonist behavior and delivery in challenged bone microenvironment
Provided by PTCRIS: 125869
125869
PTDC/BIM-MED/1047/2012
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2012/04 - 2015/03 Memristor Based Adaptive Neural Networks (MemBrAiNN)
Provided by PTCRIS: 122868
122868
PTDC/CTM-NAN/122868/2010
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2007/07 - 2010/06 Theoretical models of nociceptive information processing and transmission in the spinal cord´s dorsal horn.
68929
Provided by PTCRIS: 68929
PTDC/SAU-NEU/68929/2006
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2000/09/01 - 2001/07/31 Study of Type Ia supernovae and their cosmological implications
PESO/ESO/P/PRO/1257/98
PhD Student Fellow
Instituto Superior Técnico Departamento de Física, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2020/01/01 - 2024/12/31 Institute for Research and Innovation in Health
UIDB/04293/2020
10.54499/UIDB/04293/2020
LA/P/0070/2020
10.54499/LA/P/0070/2020
UIDP/04293/2020
10.54499/UIDP/04293/2020
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2022/06/30 Uncovering the mechanistic assembly and function of actin ring networks in axonal biology and pathology.
PTDC/MED-NEU/28623/2017
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/05/01 - 2021/12/18 New Active Medical Implants
PTDC/EEI-EEE/32348/2017
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Pathological nerve sprouting in bone metastases: OSTEOCLASTS, what are you doing
PTDC/MED-PAT/30158/2017
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - UI 144 - 2011-2012
PEst-C/MAT/UI0144/2011
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Matemática, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Dias, C.; Silva, D.J.; Aguiar, P.; Ventura, J.. "Associative networks and perceptron based on memristors: Fundamentals and algorithmic implementation". 729-765. 2019.
  2. Dias, C.; Ventura, J.; Aguiar, P.. "Memristive-based neuromorphic applications and associative memories". 2017.
    10.1007/978-3-319-51724-7_13
  3. Neto, E.; Paramos-De-Carvalho, D.; Lourenço, A.H.; Aguiar, P.; Lamghari, M.. "Compartmentalized microfluidic platforms as tool of choice to study the interaction between neurons and osteoblasts". 2015.
    10.1007/978-1-4939-2510-0_10
Conference abstract
  1. Sousa, Sara Castro; Aroso, Miguel; 5E1D-7E42-BBAD; Veríssimo, Eduardo; Brites, Pedro; Aguiar, Paulo; Sousa, Monica M; Lopes, CDF. "Tension-driven axon elongation triggers cytoskeleton and membrane remodelling". Paper presented in IUBMB-EMBO Focused Meeting On Emerging Concepts Of The Neuronal Cytoskeleton (6th Edition), Santa Cruz, 2023.
  2. Loureiro, Joana C.; Torres, Ana L.; Neto, Tânia; Aguiar, Paulo; Barrias, Cristina C.; Pinto, Marta T.; Amaral, Isabel F.. "Pro-angiogenic effect of fibrin hydrogel functionalization with the T1 sequence from CCN1". Paper presented in Second CellFit Workshop (COST Action CA16119), Belgrade, 2019.
  3. Loureiro, Joana C.; Torres, Ana L.; Aguiar, Paulo; Pinto, Marta T.; Amaral, Isabel F.. "Conjugation of the integrin a6ß1 binding domain of the angiogenic inducer CCN1 to fibrin hydrogels for therapeutic vascularization". Paper presented in 28th Annual Conference of the European Society for Biomaterials (ESB), Athens, 2017.
  4. Loureiro, Joana C.; Torres, Ana L.; Aguiar, Paulo; Pinto, Marta T.; Amaral, Isabel F.. "Fibrin hydrogels functionalized with integrin-specific adhesive cues for therapeutic vascularization in the central nervous system". Paper presented in XV Annual Meeting of the Portuguese Society for Neuroscience, Braga, 2017.
  5. Monteiro, João P.; Oliveira, Hélder P.; Aguiar, Paulo; Cardoso, Jaime S.. "Depth-map Images for Automatic Mice Behavior Recognition". Paper presented in 1st PhD. Students Conference in Electrical and Computer Engineering, Porto, 2012.
    Published
Conference paper
  1. Monteiro, J.P.; Oliveira, H.P.; Aguiar, P.; Cardoso, J.S.. "A depth-map approach for automatic mice behavior recognition". 2014.
    10.1109/ICIP.2014.7025458
  2. Aguiar, P.; David, A.; Paulo, S.; Rosa, A.. "EEGSolver - Brain activity and genetic algorithms". 2000.
    10.1145/335603.335702
Conference poster
  1. Sousa, Sara Castro; Aroso, Miguel; Veríssimo, Eduardo; Brites, Pedro; Vieira, Jorge; Cristina P. Vieira ; Aguiar, Paulo; Sousa, Monica M. Corresponding author: Sousa, Monica M. "Tension-driven growth triggers developmental stage-specific adaptations of the axonal cytoskeleton and membrane". Paper presented in Forces Across Scales - i3S, University of Porto, Portugal, 2024.
  2. Terceiro, Ana F.; Lobo, Andrea; Canedo, Teresa; Socodato, Renato; Carvalhais, Lia; Aroso, Miguel; Sousa, Mafalda; et al. "Rho GTPases in the spotlight: unveiling methamphetamine's effects on neuronal remodeling in the hippocampus". Paper presented in Neuroscience 2023, 2023.
  3. Serra, João; João Oliveira Ventura; Aguiar, Paulo; Susana Isabel Pinheiro Cardoso de Freitas; Leitao, Diana C.. Corresponding author: Serra, João. "Design and fabrication of polymer microstructures with embedded electrodes for 3D measurements". Paper presented in Micro and NanoEngineering Conference (MNE 2023), 2023.
  4. Serra, João; Henrique Teixeira; João P. Carvalho; Susana Isabel Pinheiro Cardoso de Freitas; João Oliveira Ventura; Aguiar, Paulo; Leitao, Diana C.. Corresponding author: Serra, João. "Implementation of Customized 2D-to-3D Micro Electrode Array Designs: Optimization of Passivation, Electrode Shape and Methods for Performance Assessment". Paper presented in MPS World Summit 2023, 2023.
  5. Silva, SC; Castro, Domingos; MATEUS, JOSÉ C; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "A Tripartite Microfluidic Device with Integrated Microelectrodes to Study the Neuron-Astrocyte Crosstalk". Paper presented in VII Symposium of the Portuguese Glial Network, 2023.
  6. Castro, Domingos; Aroso, Miguel; A. Pedro Aguiar; David B. Grayden; Aguiar, Paulo. "Disrupting unwanted neuronal oscillations with closed-loop". Paper presented in NER IEEE 2023, 11th International IEEE EMBS Conference on Neural, 2023.
  7. Terceiro, Ana F.; Lobo, Andrea; Canedo, Teresa; Carvalhais, Lia; Aroso, Miguel; Sousa, Mafalda; Socodato, Renato; et al. "Methamphetamine-induced modulation of RhoGTPases in hippocampal neurons and microglia (Presented by A. Terceiro)". Paper presented in n FENS-Hertie Winter School on Neuro-Immune Interactions in Health and Disease, 2023.
  8. Castro, Domingos; Aroso, Miguel; A. Pedro Aguiar; David B. Grayden; Aguiar, Paulo. "Disrupting pathological neuronal oscillations with closed-loop stimulation in vitro". Paper presented in Nature Conference - Technologies for Neuroengineering 2022, 2022.
  9. Silva, SC; Castro, Domingos; MATEUS, JOSÉ C; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "Electrical Stimulation of Astrocytes and its Impact on Astrocytic Calcium Signaling". Paper presented in VI Symposium of the Portuguese Glia Network, 2022.
  10. Serra, João; Djibril Nd, Faye; João Oliveira Ventura; Susana Isabel Pinheiro Cardoso de Freitas; Aguiar, Paulo; Leitao, Diana C.. Corresponding author: Serra, João. "Development of 3D strain engineered polymeric structures for vertical electrodes". Paper presented in EuroOCS (European Organ On Chips Society) Annual Meeting 2022, 2022.
  11. Terceiro, Ana F.; Lobo, Andrea; Canedo, Teresa; Carvalhais, Lia; Aroso, Miguel; Sousa, Mafalda; Magalhães, Ana; et al. ""Methamphetamine remodelling of hippocampal neurons is orchestrated via cdc42 pathway (Presented by A. Terceiro)". Paper presented in VI Symposium of the Portuguese Glial Network, 2022.
  12. Domingos Leite de Castro; Aroso, Miguel; Aguiar, A. Pedro; David B. Grayden; Aguiar, Paulo. Corresponding author: Domingos Leite de Castro. "Disrupting periodic neuronal synchrony with closed-loop stimulation in vitro". Paper presented in Cosyne 2022, 2022.
  13. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. Corresponding author: Catarina Dias. "Bio/electronic interfaces for neuroprosthetics". Paper presented in 3rd Condensed Matter Physics National Conference, 2022.
  14. Lobo, Andrea; Ana Filipa Terceiro; Lia Carvalhais; Aroso, Miguel; Mafalda Sousa; Ana Magalhães; Aguiar, Paulo; Relvas, João; Summavielle, Teresa. "Methamphetamine remodelling of hippocampal neurons is orchestrated via cdc42 pathway". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  15. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. "A neuromorphic system for real-time feedback stimulation of neuronal populations". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  16. Mateus JC; Lopes, CDF; Aroso, Miguel; Costa AR; Gerós, Ana; Meneses J; Faria P; et al. "New insights into the mechanisms regulating axonal development and maturation". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  17. Aroso, Miguel; Domingos Castro; Sara Silva; Leonor Sá; Aguiar, Paulo. Corresponding author: Aroso, Miguel. "Astrocytes are activated by direct electrical stimulation in the physiological range of neuronal activity". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  18. Lopes, CDF; Catarina Ricardo; Maria Ribeiro; José Mateus; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "Dissecting the regulatory effects of neuronal electrical activity on mitochondria axonal transport dynamics". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  19. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. Corresponding author: Catarina Dias. "A bio-electronic memristive interface for real-time coupling of neuronal populations". Paper presented in 4th International Conference on Memristive Materials, Devices & Systems (MEMRISYS 2021), 2021.
  20. Sara Castro Sousa; Aroso, Miguel; Tiago Silva; Lopes, CDF; Pedro Brites; Aguiar, Paulo; Sousa, Monica M. "A microfluidic platform enabling live imaging of cytoskeleton dynamics and transport of axon elongation driven by physiological stretch". Paper presented in The EMBO Workshop Axons 2021: Structure and Function, 2021.
  21. Serra, João; Djibril Nd, Faye; João Oliveira Ventura; Aguiar, Paulo; Susana Isabel Pinheiro Cardoso de Freitas; Leitao, Diana C.. Corresponding author: Serra, João. "Design of a simplified microfabrication process to obtain vertical structures from planar flexible substrates". Paper presented in Micro and Nanoengineering Conference MNE 2021, 2021.
  22. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. "Real-time adaptive coupling between neuronal populations in a hybrid bio-electronic interface using memristors". Paper presented in Nature Conference- Technologies for Neuroengineering, 2021.
  23. Aroso, Miguel; Silva, SC; Aguiar, Paulo. "Enlightening the Neuron-Astrocytes Interaction in the Electrophysiological Domain: Astrocytic Calcium Waves in Response to Electrical Stimuli". Paper presented in 8th i3S Annual Meeting, 2019.
  24. Silva, SC; Aguiar, Paulo; Aroso, Miguel. "Assessing Functional Activity of Astrocytes by Calcium Imaging: Astrocytic Calcium Signals and the Electrophysiological Environment". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  25. Conceição, Francisco; Daniela M. Sousa; Alves, Cecília J; I. S. Alencastre; Aguiar, Paulo; Lamghari, Meriem. "The Deficiency of Y1 Receptor Signalling Leads to Defective Osteoclast Bone-Resorbing Activity". Paper presented in GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network (GLISTEN) Symposium, 2017.
  26. Conceição, Francisco; Daniela M. Sousa; Aguiar, Paulo; Lamghari, Meriem. "A Computational Tool for Bone Resorption Analysis". Paper presented in 4th International Symposium in applied Bioimaging, 2015.
  27. Luz, Liliana Laracho; Pinho, Raquel; Aguiar, Paulo; Antal, Zsófia; Todd, Andrew J.; Safronov, Boris V.; Szucs, Peter. "Morphological analysis of lamina I local-circuit neurons in the lumbar spinal cord of the rat". Paper presented in Champalimaud Neuroscience Symposium, 2011.
  28. Cardoso-Cruz, Helder; Aguiar, Paulo; Lima, Deolinda; Galhardo, Vasco. "Thalamocortical global dynamics of behavioral transitions in a rat model of persistent peripheral neuropathic pain". Paper presented in X Reunião Annual da Sociedade Portuguesa de Neurociências. 2007, 24-26 Maio, Ofir, PORTUGAL., 2007.
Journal article
  1. José Mateus; Pedro Melo; Miguel Aroso; B Charlot; Paulo Aguiar. "Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits". Biofabrication (2025): https://doi.org/10.1088/1758-5090/adb2e5.
    10.1088/1758-5090/adb2e5
  2. Andreia M. Oliveira; Eduardo Carvalho; Beatriz Barros; Carolina Soares; Manuel J. Ferreira-Pinto; Rui Vaz; Paulo Aguiar. "DBScope as a versatile computational toolbox for the visualization and analysis of sensing data from deep brain stimulation". npj Parkinson's Disease (2024): https://doi.org/10.1038/s41531-024-00740-z.
    10.1038/s41531-024-00740-z
  3. J. C. Mateus; M. M. Sousa; J. Burrone; P. Aguiar; MATEUS, JOSÉ C; Sousa, Monica M; Burrone, Juan; et al. Corresponding author: Aguiar, Paulo. "Beyond a Transmission Cable—New Technologies to Reveal the Richness in Axonal Electrophysiology". The Journal of Neuroscience (2024): https://doi.org/10.1523/JNEUROSCI.1446-23.2023.
    In press • 10.1523/JNEUROSCI.1446-23.2023
  4. Domingos L Castro; Miguel Aroso; A Pedro Aguiar; David B Grayden; Paulo Aguiar. "Disrupting abnormal neuronal oscillations with adaptive delayed feedback control". eLife (2024): https://doi.org/10.7554/eLife.89151.
    10.7554/eLife.89151
  5. Andreia M. Oliveira; Luis Coelho; Eduardo Carvalho; Manuel J. Ferreira-Pinto; Rui Vaz; Paulo Aguiar. "Machine learning for adaptive deep brain stimulation in Parkinson’s disease: closing the loop". Journal of Neurology (2023): https://doi.org/10.1007/s00415-023-11873-1.
    10.1007/s00415-023-11873-1
  6. Francisca Diniz; Sofia Lamas; Hugo Osório; Paulo Aguiar; Daniela Freitas; Fátima Gärtner; Bruno Sarmento; Celso A. Reis; Joana Gomes. "Nanoparticles targeting Sialyl-Tn for efficient tyrosine kinase inhibitor delivery in gastric cancer". Acta Biomaterialia (2023): https://doi.org/10.1016/j.actbio.2023.08.014.
    10.1016/j.actbio.2023.08.014
  7. Manubens-Gil, L.; Zhou, Z.; Chen, H.; Ramanathan, A.; Liu, X.; Liu, Y.; Bria, A.; et al. "BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets". Nature Methods 20 6 (2023): 824-835. http://www.scopus.com/inward/record.url?eid=2-s2.0-85153062588&partnerID=MN8TOARS.
    10.1038/s41592-023-01848-5
  8. Margarida Dantas; Andreia Oliveira; Paulo Aguiar; Helder Maiato; Jorge G. Ferreira. "Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation". Journal of Cell Biology (2022): https://doi.org/10.1083/jcb.202205051.
    10.1083/jcb.202205051
  9. Eduardo Conde-Sousa; João Vale; Ming Feng; KELE XU; Yin Wang; Della Mea V; David La Barbera; et al. "HEROHE Challenge: Predicting HER2 Status in Breast Cancer from Hematoxylin–Eosin Whole-Slide Imaging". Journal of Imaging (2022): https://www.mdpi.com/2313-433X/8/8/213.
    10.3390/jimaging8080213
  10. Ana C. Almeida; Joana Soares-de-Oliveira; Danica Drpic; Liam P. Cheeseman; Joana Damas; Harris A. Lewin; Denis M. Larkin; et al. "Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals". Cell Reports (2022): https://doi.org/10.1016/j.celrep.2022.110610.
    10.1016/j.celrep.2022.110610
  11. Urša Blenkuš; Ana Filipa Gerós; Cristiana Carpinteiro; Paulo de Castro Aguiar; I. Anna S. Olsson; Nuno Henrique Franco. "Non-Invasive Assessment of Mild Stress-Induced Hyperthermia by Infrared Thermography in Laboratory Mice". Animals (2022): https://doi.org/10.3390/ani12020177.
    10.3390/ani12020177
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  73. Castro, L.; Aguiar, P.. "Phase precession through acceleration of local theta rhythm: A biophysical model for the interaction between place cells and local inhibitory neurons". Journal of Computational Neuroscience 33 1 (2012): 141-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861878587&partnerID=MN8TOARS.
    10.1007/s10827-011-0378-0
  74. Pinto, S.; Krishna, R.; Dias, C.; Pimentel, G.; Oliveira, G.N.P.; Teixeira, J.M.; Aguiar, P.; et al. "Resistive switching and activity-dependent modifications in Ni-doped graphene oxide thin films". Applied Physics Letters 101 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865141673&partnerID=MN8TOARS.
    10.1063/1.4742912
  75. Pais-Vieira, M.; Aguiar, P.; Lima, D.; Galhardo, V.. "Inflammatory pain disrupts the orbitofrontal neuronal activity and risk-assessment performance in a rodent decision-making task". Pain 153 8 (2012): 1625-1635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863720383&partnerID=MN8TOARS.
    10.1016/j.pain.2012.04.011
  76. Aguiar, P.; Sousa, M.; Lima, D.. "NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons". Journal of Neurophysiology 104 2 (2010): 1155-1166. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955972258&partnerID=MN8TOARS.
    10.1152/jn.00834.2009
  77. Vourvouhaki, E.; Carvalho, C.; Aguiar, P.. "Model for Osteosarcoma-9 as a potent factor in cell survival and resistance to apoptosis". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 76 1 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547619785&partnerID=MN8TOARS.
    10.1103/PhysRevE.76.011926
  78. Aguiar, P.; Mendonça, L.; Galhardo, V.. "OpenControl: A free opensource software for video tracking and automated control of behavioral mazes". Journal of Neuroscience Methods 166 1 (2007): 66-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548491369&partnerID=MN8TOARS.
    10.1016/j.jneumeth.2007.06.020
  79. Aguiar, P.; Willshaw, D.. "Hippocampal mossy fibre boutons as dynamical synapses". Neurocomputing 58-60 (2004): 699-703. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542481831&partnerID=MN8TOARS.
    10.1016/j.neucom.2004.01.116
Preprint
  1. Miguel Aroso; Domingos Castro; Sara Costa Silva; Paulo Aguiar. "Bringing astrocytes into the spotlight of electrical brain stimulation". 2024. https://doi.org/10.1101/2024.02.28.582466.
    10.1101/2024.02.28.582466
  2. João Serra; José C. Mateus; Susana Cardoso; João Ventura; Paulo Aguiar; Diana C. Leitao. "Stress-actuated Flexible Microelectrode Arrays for Activity Recording in 3D Neuronal Cultures". 2024. https://doi.org/10.1101/2024.12.12.628189.
    10.1101/2024.12.12.628189
  3. Andreia M. Oliveira; Eduardo Carvalho; Beatriz Barros; Carolina Soares; Manuel Ferreira-Pinto; Rui Vaz; Paulo Aguiar. "DBScope: a versatile computational toolbox for the visualization and analysis of sensing data from Deep Brain Stimulation". 2023. https://doi.org/10.1101/2023.07.23.23292136.
    10.1101/2023.07.23.23292136
  4. Domingos Leite de Castro; Miguel Aroso; A. Pedro Aguiar; David B. Grayden; Paulo Aguiar. "Adaptive delayed feedback control disrupts unwanted neuronal oscillations and adjusts to network synchronization dynamics". 2022. https://doi.org/10.1101/2022.07.05.498735.
    10.1101/2022.07.05.498735
  5. Ana Gerós; Ricardo Cruz; Fabrice de Chaumont; Jaime S. Cardoso; Paulo Aguiar. "Deep learning-based system for real-time behavior recognition and closed-loop control of behavioral mazes using depth sensing". 2022. https://doi.org/10.1101/2022.02.22.481410.
    10.1101/2022.02.22.481410
  6. Margarida Dantas; Andreia Oliveira; Paulo Aguiar; Helder Maiato; Jorge G. Ferreira. "Mechanosensitive control of mitotic entry". 2021. https://doi.org/10.1101/2021.09.23.461473.
    10.1101/2021.09.23.461473

Other

Dataset
  1. BACH Dataset : Grand Challenge on Breast Cancer Histology images.
    10.5281/zenodo.3632035
  2. RGB-D Rat Behavioral Dataset.
    10.5281/zenodo.3636136
  3. MATEUS, JOSÉ C; Aguiar, Paulo. Sample raw data for publication "Bidirectional flow of action potentials in axons drives activity dynamics in neuronal cultures".
    10.5281/zenodo.5745979
  4. MATEUS, JOSÉ C; Aguiar, Paulo. Data for publication "Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits". https://zenodo.org/records/14525182. 2024.
    10.5281/zenodo.14525181
Other output
  1. Nanoparticles Targeting Sialyl-Tn for Tyrosine Kinase Inhibitor Efficient Delivery in Gastric Cancer. 2023. Diniz, F.; Lamas, S.; Osório, H.; Aguiar, P.; Freitas, D.; Gartner, F.; Sarmento, B.; Reis, C.A.; Gomes, J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85147570161&partnerID=MN8TOARS.
    10.2139/ssrn.4347869
  2. A memristor-based neuromodulation device for real-time monitoring and adaptive control of in vitro neuronal populations. 2021. Catarina Dias; Domingos Castro; Miguel Aroso; João Ventura; Paulo Aguiar. https://doi.org/10.1101/2021.05.20.444941.
    10.1101/2021.05.20.444941
  3. In vitro neuronal networks show bidirectional axonal conduction with antidromic action potentials effectively depolarizing the soma. 2021. Mateus, J.C.; Lopes, C.D.F.; Aroso, M.; Costa, A.R.; Gerós, A.; Pereira, A.; Meneses, J.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105400648&partnerID=MN8TOARS.
    10.1101/2021.03.07.434278
  4. Kinetochore-mediated microtubule assembly and Augmin-dependent amplification drive k-fiber maturation in mammals. 2021. Almeida, A.C.; Oliveira, J.; Drpic, D.; Cheeseman, L.P.; Damas, J.; Lewin, H.A.; Larkin, D.M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118903356&partnerID=MN8TOARS.
    10.1101/2021.08.18.456780
  5. HEROHE Challenge: Assessing HER2 status in breast cancer without immunohistochemistry or in situ hybridization. 2021. Conde-Sousa, E.; Vale, J.; Feng, M.; Xu, K.; Wang, Y.; Mea, V.D.; Barbera, D.L.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85169487309&partnerID=MN8TOARS.
    10.48550/arxiv.2111.04738
  6. Mechanosensitive nuclear asymmetries define a bipolar spindle scaffold to ensure mitotic fidelity. 2019. Nunes, V.; Dantas, M.; Castro, D.; Vitiello, E.; Wang, I.; Carpi, N.; Balland, M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095641297&partnerID=MN8TOARS.
    10.2139/ssrn.3434727
  7. Sensory neurons sprouting is dependent on osteoclast-derived extracellular vesicles involving the activation of epidermal growth factor receptors. 2018. Estrela Neto; Luís Leitão; José Mateus; Daniela M. Sousa; Francisco Conceição; Cecília J. Alves; Richard O. C. Oreffo; et al. https://doi.org/10.1101/259218.
    10.1101/259218
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017 - Current Workshop on Neuroengineering (2017)
Workshop (President of the Organising Committee)
2018 - 2019 Future of Computing (2018 - 2019)
Workshop (Co-organisor)
2014 - 2016 International Symposium in Applied Bioimaging (2014 - 2016)
Symposium (Co-organisor)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019 Transcutaneous spinal direct current stimulation: modelling the spinal electric field distribution and clinical relevance
(Thesis) Arguer
 Sofia Rita Fernandes (PhD)
Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal
2016 LocoMouse: a novel system for studying the role of cerebellum in gait coordination
(Thesis) Arguer
 Ana Sofia Rodrigues Machado (PhD)
2014 Multi-bump solutions in dynamic neural fields: Analysis and Applications
(Thesis) Main arguer
 Flora Ferreira (PhD)
2014 Efficient storage and retrieval of memories in neural networks
(Thesis) Main arguer
 João Sacramento (PhD)
Instituto Superior Técnico Departamento de Física, Portugal
2009 Numerical modelling in Transcranial Magnetic Stimulation
(Thesis) Main arguer
 Ricardo Salvador (PhD)

Association member

Society Organization name Role
2006 - Current Sociedade Portuguesa de Neurociências
1999 - 2000 NFIST Astronomy Group Director

Committee member

Activity description
Role 		Institution / Organization
2019 - Current Vice-Coordinator of the Neurobiology and Neurologic Disorders (NDD) Integrative Program at i3S
Coordinator
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2000 - 2001 IST Physics Degree Committee (only non-Professor member)
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Introduction to Python and Fundamental Concepts in Machine Learning (Outros) Universidade do Porto, Portugal
2017 - Current Neuroengineering (Mestrado integrado) Universidade do Porto Faculdade de Engenharia, Portugal
2010 - 2020 Introduction to Scientific Programming with MATLAB (Outros)
2016 - 2018 NEUBIAS - International school on bioimage analysis
2014 - 2018 Medical Biophysics (Mestrado integrado)
2016 - 2017 CAJAL Course in Computational Neuroscience Programa Champalimaud de Neurociências, Portugal
2008 - 2017 Computational Neuroscience (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2012 Mathematics in Biology; Computational Biology (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2002 - 2004 Teaching Assistant (in M.Sc. courses): 1) "Neural Computation"; 2) "Learning from Data"; 3) "Maths Refresher" (Master) The University of Edinburgh Institute for Adaptive and Neural Computation, United Kingdom
1998 - 2000 Teaching Assistant (in B.Sc. courses): 1) "Physics II"; 2) "Computational Physics" (Bacharelato)