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Angel Luis Alvarez Rodriguez. Completed the Doctor of Philosophy (PhD) Programme in Molecular Biology in 2015/12/17 by Universidad de Oviedo; Master in Microbiology and Virology in 2007/07/31 and Licence in Microbiology in 2005/07/31 by Universidad de la Habana. He is an assistant professor of Biochemistry at the Department of Biochemistry and Molecular Biology, University of Oviedo (Spain). Previous positions include an Instructor appointment at the University of Havana (2005-2009) and a post-doctoral fellowship at the Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School (Boston, USA) (2016-2019). He is a member of the American Society for Microbiology (ASM), American Society for Virology (ASV), World Society for Virology (WSV) and the Spanish Society for Virology (SEV). His current research concerns the molecular biology of virus replication, virus-host interactions, and virus reverse genetics, with a focus in the search for novel antiviral strategies.
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Identification

Personal identification

Full name
Angel Luis Alvarez Rodriguez
Gender
Male

Citation names

  • Álvarez, AL

Author identifiers

Ciência ID
F415-6379-78FB
ORCID iD
0000-0001-9388-8595
Google Scholar ID
https://scholar.google.es/citations?user=PP5kc2kAAAAJ&hl=en
Researcher Id
B-2004-2015
Scopus Author Id
35069014500

Email addresses

  • alvarezrangel@uniovi.es (Professional)

Telephones

Telephone
  • (+34) 985103569 (Professional)

Addresses

  • Departamento de Bioquímica y Biología Molecular. C/ Fernando Bongera sn, Edificio Santiago Gascón, Campus El Cristo, 33006, Asturias, Oviedo, Spain (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2010/01/01 - 2015/12/17
Concluded
 PhD Programme in Molecular Biology (Doctor of Philosophy)
Universidad de Oviedo Departamento de Bioquímica y Biología Molecular, Spain
"Expression vectors based on genome-length Rabbit vesivirus (RaV) cDNAs and analysis of their functionality as infectious clones" (THESIS/DISSERTATION)
2005/09/01 - 2007/07/31
Concluded
 Master in Microbiology and Virology (Master)
Universidad de la Habana Facultad de Biologia, Cuba
2000/09/01 - 2005/07/31
Concluded
 Microbiology (Licence)
Universidad de la Habana Facultad de Biologia, Cuba
Affiliation

Science

Category
Host institution 		Employer
2017/02/17 - 2019/11/18 Postdoc (Research) Brigham and Women's Hospital Channing Division of Network Medicine, United States
Harvard Medical School Department of Medicine, United States

Teaching in Higher Education

Category
Host institution 		Employer
2019/11/20 - Current Assistant Professor (University Teacher) Universidad de Oviedo Departamento de Bioquímica y Biología Molecular, Spain
Projects

Grant

Designation Funders
2021/11/29 - 2023/12/31 Virología y Parasitologia Molecular (VYPMOL)
AYUD/2021/51288
Principal investigator
Universidad de Oviedo Departamento de Bioquímica y Biología Molecular, Spain
 Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología
Ongoing
Outputs

Publications

Journal article
  1. Ángel L. Álvarez; Kevin P. Dalton; Inés Nicieza; Fabio A. Abade Dos Santos; Pilar de la Peña; Pedro Domínguez; José M. Martin-Alonso; Francisco Parra; Daniela S. Rajao. "Virucidal Properties of Photocatalytic Coating on Glass against a Model Human Coronavirus". Microbiology Spectrum (2022): https://doi.org/10.1128/spectrum.00269-22.
    10.1128/spectrum.00269-22
  2. Min Tan; Shijun Li; Franceline Juillard; Rute Chitas; Tânia F Custódio; Han Xue; Agnieszka Szymula; et al. "MLL1 is regulated by KSHV LANA and is important for virus latency". Nucleic Acids Research (2021): https://doi.org/10.1093/nar/gkab1094.
    10.1093/nar/gkab1094
  3. "Truncated Precursor of Feline calicivirus Major Capsid Protein: A Product Relevant for Replication, or an Aberrant Translation Artifact?". Intervirology 64 2 (2021): 108-110. https://doi.org/10.1159/000513965.
    10.1159/000513965
  4. "Reverse Genetics System for Rabbit vesivirus". Frontiers in Microbiology 11 (2020): http://dx.doi.org/10.3389/fmicb.2020.596245.
    10.3389/fmicb.2020.596245
  5. Franceline Juillard; Marta Pires de Miranda; Shijun Li; Aura Franco; André F. Seixas; Bing Liu; Ángel L. Álvarez; et al. "KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence". Proceedings of the National Academy of Sciences 117 36 (2020): 22443-22451. https://doi.org/10.1073/pnas.2004809117.
    10.1073/pnas.2004809117
  6. Beatriz Novoa; Alejandro Romero; Ángel L. Álvarez; Rebeca Moreira; Patricia Pereiro; María M. Costa; Sonia Dios; et al. "Antiviral activity of myticin C peptide from mussel: an ancient defence against herpesviruses". J. Virol. (2016): JVI.00591-16. http://dx.doi.org/10.1128/jvi.00591-16.
    10.1128/jvi.00591-16
  7. Álvarez, Ángel L.; Habtemariam, Solomon; Parra, Francisco. "Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication". Natural Product Research (2015): 1-6.
    10.1080/14786419.2015.1007456
  8. Dalton, K.P.; Abrantes, J.; Lopes, A.M.; Nicieza, I.; Álvarez, Á.L.; Esteves, P.J.; Parra, F.. "Complete genome sequence of two rabbit hemorrhagic disease virus variant b isolates detected on the Iberian Peninsula". Archives of Virology 160 3 (2015): 877-881. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923297559&partnerID=MN8TOARS.
    10.1007/s00705-014-2329-3
  9. Álvarez, Á.L.; Habtemariam, S.; Abdel Moneim, A.E.; Melón, S.; Dalton, K.P.; Parra, F.. "A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in vero cells". Antiviral Research 119 (2015): 8-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928477949&partnerID=MN8TOARS.
    10.1016/j.antiviral.2015.04.004
  10. Álvarez, Ángel L.; Melón, Santiago; Dalton, Kevin P.; Nicieza, Inés; Roque, Annele; Suárez, Belén; Parra, Francisco. "Apple Pomace, a By-Product from the Asturian Cider Industry, Inhibits Herpes Simplex Virus Types 1 and 2 In Vitro Replication: Study of Its Mechanisms of Action". (2012):
    10.1089/jmf.2011.0308
  11. Dalton, Kevin P.; Nicieza, Inés; Balseiro, Ana; Muguerza, María A.; Rosell, Joan M.; Casais, Rosa; Álvarez, Ángel L.; Parra, Francisco. "Variant rabbit hemorrhagic disease virus in young rabbits, Spain". Emerging infectious diseases 18 12 (2012): 2009-2009.
    10.3201/eid1812.120341
  12. "Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds". Phytotherapy Research 26 10 (2012): 1513-1520. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867329781&partnerID=MN8TOARS.
    10.1002/ptr.4608
  13. Barrio, Gloria del; Spengler, Iraida; García, Trina; Roque, Annele; Álvarez, Ángel L.; Calderón, José S.; Parra, Francisco. "Antiviral activity of Ageratina havanensis and major chemical compounds from the most active fraction". Revista Brasileira de Farmacognosia 21 5 (2011): 915-920.
    10.1590/S0102-695X2011005000159
  14. Álvarez, A.L.; Habtemariam, S.; Juan-Badaturuge, M.; Jackson, C.; Parra, F.. "In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action". Phytotherapy Research 25 2 (2011): 296-301. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551670175&partnerID=MN8TOARS.
    10.1002/ptr.3382
  15. Suárez, Belén; Álvarez, Ángel L.; García, Yolanda Diñeiro; del Barrio, Gloria; Lobo, Anna Picinelli; Parra, Francisco. "Phenolic profiles, antioxidant activity and in vitro antiviral properties of apple pomace". Food chemistry 120 1 (2010): 339-342.
    10.1016/j.foodchem.2009.09.073
  16. Álvarez, Ángel L.; del Barrio, Gloria; Kourí, Vivian; Martínez, Pedro A.; Suárez, Belén; Parra, Francisco. "In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis". Phytomedicine 16 10 (2009): 960-966.
    10.1016/j.phymed.2009.03.023
  17. Alonso, G.D.B.; Rodríguez, Á.L.A.; García, S.M.V.; Fernández, F.P.. "Methodology for the preclinical screening of anti-herpesvirus activity starting from natural products,Metodología de pesquisa preclínica de actividad antiherpesvirus a partir de productos naturales". Revista Cubana de Farmacia 42 2 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-52249083253&partnerID=MN8TOARS.
  18. Álvarez Rodríguez, Á.L.; Alonso, G.D.B.. "Antiviral properties of plants of the genus Phyllanthus,Propiedades antivirales de plantas del género Phyllanthus". Revista Cubana de Farmacia 42 1 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-47349125364&partnerID=MN8TOARS.