I have a Licenciatura (2002) and MsC (2006) in Informatics Engineering from Instituto Superior Tecnico, and PhD in Bioinformatics (Aix-Marseille University, 2009), supervised by Patrick Lemaire, on the analysis of gene expression and transcriptional regulation in development, resulting in 2 first author publications (111 citations according to Web of Science in November 2023). I did postdoctoral work at the European Bioinformatics Institute, under supervision of Ian Dunham, designing and implementing pipelines to analyze hundreds of human and mouse epigenomic datasets from large projects such as ENCODE. I contributed to 2 major publications (with a combined total of 12004 citations), resulting in the revelation that around 80% of the genome has a potential regulatory function. I helped integrate these results in ENSEMBL, a widely used resource in the life sciences (4 publications, 2114 citations). In 2012 I became a postdoc at Instituto Gulbenkian de Ciência (IGC), and in 2014-2019 head of the Bioinformatics Facility, leading a team of 4-6 persons providing bioinformatics support. I collaborated in several projects at IGC (13 publications, with 269 citations). In 2019 I moved to UCIBIO FCT-NOVA in 2019 to develop my scientific independence and focus on projects related to cancer biology. I contributed to writing the successful application Onco-HIT (250.000¿), where I worked to uncover possible molecular origins of intratumor heterogeneity. I nurtured collaborations producing several results, regarding tumor immune evasion (Fior et al. 2021, 32 citations); the role of glycosylation in human health (Sobral et. al, 2022, publication as first author) and disease tolerance (Singh et al. 2021a, 2021b, 17 citations) and the interplay between genetic and microenvironment heterogeneity in CRC progression (Sobral et al. 2022, publication as first author). In 2022 I moved to INSA Ricardo Jorge in Lisbon, under the supervision of João Paulo Gomes, within the bioinformatics group of the Department of Infectious Diseases, to contribute to viral and microbial pathogen surveillance. I contributed to the effort facing the beginning of the Monkeypox outbreak in Portugal, originating 2 high impact publications (Isidro et al., 2022, 309 citations; Borges et al., 2023). During my scientific career in Biology and Bioinformatics I contributed to 29 publications (13500 citations, 16 h-index), one receiving PLOS Genetics Research Prize 2015, and participated in 9 national and international projects. I lectured 13 courses at MsC and PhD level. I was responsible for the Research in Bioinformatics course of the MsC in Bioinformatics (FCUL). I contributed to the conception of a new Bioinformatics Masters at FCT-NOVA. I organized and taught 10 practical courses in bioinformatics within the GTPB programme at IGC,. I wrote and won grants to organize 2 EMBO practical courses. I supervised and mentored 9 MSc students, 1 PhD student, and examined 2 PhD and 6 MSc thesis. I was a member of the Elixir european bioinformatics infrastructure, and contributed to the genesis of BioData.pt, the portuguese node of Elixir. I was also the MC substitute from Portugal in the COST action CA15205.