I have a “Licenciatura” (2002) and MsC (2006) in Information Systems and Computer Engineering from Instituto Superior Tecnico, and a PhD in Bioinformatics (Aix-Marseille University, 2009) under supervision of Patrick Lemaire. My doctoral work focused on the analysis of gene expression and transcriptional gene regulation during development, resulting in 2 first author publications (totalling 95 citations according to Web of Science in February 2020). After my PhD, I did postdoctoral work at the European Bioinformatics Institute, under supervision of Ian Dunham. During this period I designed and implemented pipelines for the analysis of hundreds of human and mouse epigenomic datasets from large projects such as ENCODE, where I contributed to 2 major publications (with a combined total of 8278 citations), resulting in the surprising revelation that around 80% of the genome has a potential regulatory function. I then helped integrate these results in ENSEMBL, one of the most widely used resources in the scientific community (4 publications, 1966 citations). In 2012-2014 I was a postdoctoral fellow at Instituto Gulbenkian de Ciência (IGC), and starting in 2014 I became Head of the Bioinformatics Facility, leading a team of 4-6 persons providing bioinformatics support to the research community. In that role, I collaborated in several projects (resulting in 7 publications with 113 citations), including: Isabel Gordo, studying the evolution of bacterial populations during colonization of the mouse gut; Lars Jensen, studying how can epigenetic marks be used as phenotypic memory during cellular progression; Jocelyne Demengeot, investigating the connection between the epigenetic state of the genome and genomic recombination characteristic of immune cells. In 2019, I moved to UCIBIO FCT-NOVA to focus on projects related to cellular diversity in health and disease, towards more translatable biomedical research. Particularly, I’ve been working within the FCT funded project Onco-Hit, performing a pan-cancer assessment of tumor heterogeneity. At UCIBIO I started novel collaborations, namely with Paula Videira, assessing the role of glycosylation in tumorigenesis and immunoreactive potential for targeted therapies. During my scientific career in Bioinformatics I published 21 papers (10452 citations, 11 h-index), one receiving PLOS Genetics Research Prize 2015, and participated in 7 projects, national and international. Since 2012 I lectured in 13 courses at MsC and PhD level, and in 2018 I was responsible for the Research in Bioinformatics course of the MsC in Bioinformatics and Computational Biology (FCUL). I organized and taught 10 courses in the Gulbenkian Training Program in Bioinformatics, and 2 EMBO practical courses. I supervised and mentored 6 MSc students, 1 PhD student, and examined 1 PhD and 5 MSc thesis. I am a member of the Elixir european bioinformatics infrastructure, and I contributed to the genesis of BioData.pt, the portuguese node of Elixir. I am also the MC substitute from Portugal in the COST action CA15205, on gene regulation. Within these networks, I am sharing best practices and expertise, namely by organizing workshops in Bioinformatics.