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Stefanie Lopes dos Santos. Completed the Mestrado in Laboratorial and Clinical Biology in 2014 by Universidade de Trás-os-Montes e Alto Douro, Licenciatura in Biochemistry in 2012 by Universidade de Trás-os-Montes e Alto Douro and Doktor (PhD) in Pharmaceutical Sciences in 2020 by Universität Basel. Is Researcher in Universidade de Trás-os-Montes e Alto Douro. Published 7 articles in journals. Has received 1 awards and/or honors. Participates and/or participated as Research Fellow in 1 project(s) and Researcher in 1 project(s).
Identification

Personal identification

Full name
Stefanie Lopes dos Santos

Citation names

  • Santos, Stefanie

Author identifiers

Ciência ID
0A1F-1BA1-8CF3
ORCID iD
0000-0002-2020-6538

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2016 - 2020
Concluded
 Pharmaceutical Sciences (Doktor (PhD))
Universität Basel, Switzerland
"Pharmaceutical Research on Bryophyllum pinnatum" (THESIS/DISSERTATION)
 05/06
2011 - 2014
Concluded
 Laboratorial and Clinical Biology (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Apoptotic Potencial of copper: in vitro study. Expression of caspases 3, 8 and 9, AIF and protein p53" (THESIS/DISSERTATION)
 19/20
2005 - 2012
Concluded
 Biochemistry (Bachelor)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Evaluation of the expression of adherent molecules during lung development. Mechanisms involved in the respiratory syndrome of premature infants" (THESIS/DISSERTATION)
 19/20
Affiliation

Science

Category
Host institution 		Employer
2024/09/01 - Current Researcher (Research) Universidade de Trás-os-Montes e Alto Douro, Portugal
Universidade de Trás-os-Montes e Alto Douro, Portugal
2016/06/01 - 2016/08/31 Research Trainee (Research) UniversitätsSpital Zürich, Switzerland

Others

Category
Host institution 		Employer
2024/05/15 - 2024/08/31 Research Fellow (Project BE@T com a Referência nº BI/UTAD/21/2024) Universidade de Trás-os-Montes e Alto Douro, Portugal
Universidade de Trás-os-Montes e Alto Douro, Portugal
2023/10/01 - 2023/12/15 Laboratory Technician Cosmetek, Portugal
Projects

Contract

Designation Funders
2024/09/01 - 2025/08/31 ANSWER - SustAiNable Safe WinERies: Identification and mapping of microorganisms and their susceptibility to UVC radiation - new approach to develop robots for winery disinfection
C644866286-00000011
Researcher
I&D Vine&Wine Portugal Driving Sustainable Growth Through Smart Innovation, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2024/07/15 - 2024/08/31 BE@T – Bioeconomy for Textiles and Clothing to Reinforce the National Bioeconomy, Textile and Clothing Sector
BI/UTAD/21/2024
Research Fellow
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. Santos, Stefanie; Simões-Wust, Ana Paula. "Bryophyllum pinnatum attenuates oxytocin-induced pro-inflammatory signalling pathways in human myometrial cells". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), 2023.
  2. Santos, Stefanie; Simões-Wust, Ana Paula. "Bryphyllum pinnatum prevents Prostaglandin F2¿-induced contractility of human myometrium in vitro". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), 2022.
  3. Santos, Stefanie; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit oxytocin-induced signalling pathways in human myometrial cells". Paper presented in Tetranacional Congress: Phytotherapy, 2022.
  4. Santos, Stefanie; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit oxytocin-induced signalling pathways in human myometrial cells". Paper presented in 69º International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, 2021.
  5. Santos, Stefanie; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in 67º International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, 2019.
  6. Santos, Stefanie; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit the oxytocin-induced rise of intracellular calcium concentration in human myometrial cells". Paper presented in 67º International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, 2019.
  7. Santos, Stefanie; Simões-Wust, Ana Paula. "Bryophyllum pinnatum compounds inhibit the oxytocin-induced rise of intracellular calcium concentration in human myometrial cells". Paper presented in 12º Swiss Pharma Science Day, 2019.
  8. Santos, Stefanie; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), 2019.
  9. Santos, Stefanie; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in 11º Swiss Pharma Science Day, 2018.
  10. Santos, Stefanie; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in 22º International Congress Phytopharm, 2018.
  11. Santos, Stefanie; Simões-Wust, Ana Paula. "A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), 2018.
  12. Santos, Stefanie; Simões-Wust, Ana Paula. "In vitro effect on myometrium contractility of a combination of Bryophyllum pinnatum press juice and atosiban". Paper presented in 65º International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - GA, 2017.
  13. Santos, Stefanie; Simões-Wust, Ana Paula. "In vitro effect on myometrium contractility of a combination of Bryophyllum pinnatum press juice and atosiban". Paper presented in 10º Swiss Pharma Science Day, 2017.
  14. Santos, Stefanie; Simões-Wust, Ana Paula. "In vitro effect on myometrium contractility of a combination of Bryophyllum pinnatum press juice and nifedipine". Paper presented in 10º Swiss Pharma Science Day, 2017.
  15. Santos, Stefanie; Simões-Wust, Ana Paula. "In vitro effect of Bryophyllum pinnatum press juice combined with atosiban on myometrium contractility". Paper presented in SGGG (Swiss Society of Gynaecology and Obstetrics), 2017.
  16. Santos, Stefanie; Sandra Mariza Monteiro; Álvaro, Ana Rita. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: expression of Caspases 3, 8 and 9, AIF and p53". Paper presented in • SEB’s (Society for Experimental Biology), 2014.
Journal article
  1. Zurfluh, Leonie; Santos, Stefanie; Ruppen, Annina; Mosbacher, Johannes; Haslinger, Christian; Ochsenbein-Kölble, Nicole; Potterat, Olivier; Simões-Wüst, Ana Paula. "Bryophyllum pinnatum modulation of signaling pathways relevant for preterm labor in human myometrial cells". Biomedicine & Pharmacotherapy 184 (2025): 117919. https://doi.org/10.1016/j.biopha.2025.117919.
    Published • 10.1016/j.biopha.2025.117919
  2. Santos, Stefanie; Zurfluh, L.; Mennet, M.; Potterat, O.; von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Corrigendum: Bryophyllum pinnatum compounds inhibit oxytocin-induced signaling pathways in human myometrial cells (Front. Pharmacol., (2021), 12, 632986, 10.3389/fphar.2021.632986)". Frontiers in Pharmacology 14 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85148603150&partnerID=MN8TOARS.
    10.3389/fphar.2023.1141346
  3. Santos, S.; Zurfluh, L.; Mennet, M.; Potterat, O.; von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Bryophyllum pinnatum Compounds Inhibit Oxytocin-Induced Signaling Pathways in Human Myometrial Cells". Frontiers in Pharmacology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102148393&partnerID=MN8TOARS.
    10.3389/fphar.2021.632986
  4. Santos, S.; Haslinger, C.; Klaic, K.; Faleschini, M.T.; Mennet, M.; Potterat, O.; Von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility in Vitro". Planta Medica 85 5 (2019): 385-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062947790&partnerID=MN8TOARS.
    10.1055/a-0810-7704
  5. Santos, S.; Haslinger, C.; Mennet, M.; Von Mandach, U.; Hamburger, M.; Simões-Wüst, A.P.. "Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: An in vitro study". BMC Complementary and Alternative Medicine 19 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074545700&partnerID=MN8TOARS.
    10.1186/s12906-019-2711-5
  6. Füeg, F.; Santos, S.; Haslinger, C.; Stoiber, B.; Schäffer, L.; Grünblatt, E.; Zimmermann, R.; Simões-Wüst, A.P.. "Influence of oxytocin receptor single nucleotide sequence variants on contractility of human myometrium: An in vitro functional study". BMC Medical Genetics 20 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075044407&partnerID=MN8TOARS.
    10.1186/s12881-019-0894-8
  7. Santos, S.; Silva, A.M.; Matos, M.; Monteiro, S.M.; Álvaro, A.R.. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53". Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 185-186 (2016): 138-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963665511&partnerID=MN8TOARS.
    10.1016/j.cbpc.2016.03.010
  8. Santos, S; Carvalho, R; Pinto, M; Coelho, A C; Gonçalves, C; Bairos, V. "Expression of E-Cadherin and Beta-Catenin in the Developing Lung after Prenatal Administration of Vitamin A". Pediatric Research 70 (2011): 544-544. https://doi.org/10.1038/pr.2011.769.
    10.1038/pr.2011.769
Thesis / Dissertation
  1. "Pharmaceutical Research on Bryophyllum pinnatum". PhD, Universität Basel Philosophisch-Naturwissenschaftliche Fakultät, 2020. http://efaidnbmnnnibpcajpcglclefindmkaj/https://edoc.unibas.ch/78878/1/Dissertation_Santos.pdf.
  2. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53". Master, Universidade de Trás-os-Montes e Alto Douro, 2014. https://catalogo.biblioteca.utad.pt/cgi-bin/koha/opac-detail.pl?biblionumber=69042.
  3. "Avaliation of the aderent molecules expression during pulmonar development. Mecanisms involved in the respiratory síndrome of premature babies". Degree, Universidade de Trás-os-Montes e Alto Douro, 2011. https://catalogo.biblioteca.utad.pt/cgi-bin/koha/opac-detail.pl?biblionumber=64327.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07 Bryophyllum pinnatum compounds inhibit the oxytocin-induced rise of intracellular calcium concentration in human myometrial cells Natural Products in Drug Discovery and Human Health Conference
(Lisboa, Portugal)
2019/04 A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro 18º Day of Clinical Research
(Zurique, Switzerland)
2018/06 A bufadienolide-enriched fraction of Bryophyllum pinnatum inhibits human myometrial contractility in vitro 22º International Congress Phytopharm
(Horgen, Switzerland)
2017/06 In vitro effect of Bryophyllum pinnatum press juice combined with atosiban on myometrium contractility SGGG (Swiss Society of Gynaecology and Obstetrics)
(Lausanne, Switzerland)
2014/07 Copper induced apoptosis in Caco-2 and Hep-G2 cells: expression of Caspases 3, 8 and 9, AIF and p53 SEB’s (Society for Experimental Biology) Annual Main Meeting
(Manchester, United Kingdom)

Mentoring / Tutoring

Topic Student name
2025/01 - 2025/06 Pharmacological research using microorganisms Tomé Cá Júnior
2024/10 - 2025/01 Identification of Bacteria and Yeast Gertrudes Marisa Chissuquila
2019/01 - 2019/06 Effects of Bryophyllum pinnatum on in vitro cell viability Kristian Klaic
2019/01 - 2019/01 Effect of Bryophyllum pinnatum on oxytocin-induced signalling pathways in human myometrium Leonie Zurfluh
2018/01 - 2018/08 Influence of oxytocin receptor polymorphisms on the in vitro contractility of human myomentrium strips Fabienne Fueg
2013/01 - 2013/06 Apoptotic potencial of copper: in vitro study in Hep-G2 cells Ana João Rocha Fernandes
2013/01 - 2013/06 Effect of copper toxicity in apoptose induction in the human epitelial intestinal cell line Caco-2 Tânia Monteiro Marques
Distinctions

Award

2018 Award of Best Poster in Pharmaceutical Biology at the 11º Swiss Pharma Science Day