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Rosa Sancho is Director of Discoveries at MIA-Portugal (Multidisciplinary Institute on Ageing), Universidade de Coimbra, where she has been part of the senior leadership team since 2023. She supports delivery of the institute's science strategy during a critical growth phase, with responsibility for external funding, ethics governance, training and development, and human resources, and has implemented core administrative and operational systems to strengthen MIA-Portugal's competitiveness in national and European funding frameworks. Rosa's career spans bench science and research strategy leadership. She holds a PhD in Neuroscience from University College London and completed postdoctoral research at King's College London, working on ER-mitochondria interactions in motor neurone disease and BDNF signalling in Alzheimer's disease. She then spent over a decade at funding agency Alzheimer's Research UK as Head of Research, where she oversaw an annual research portfolio of approximately £30 million, managed several funding schemes across discovery, translational and clinical research, and led strategic funding initiatives including the Drug Discovery Alliance and Dementia Consortium. She subsequently served as Head of Translation Operations at the Francis Crick Institute, coordinating cross-functional teams to accelerate translational research.
Identificação

Identificação pessoal

Nome completo
Rosa Maria Moreira Sancho

Nomes de citação

  • Sancho, Rosa M

Identificadores de autor

Ciência ID
F711-54CF-C0ED

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Formação
Grau Classificação
2009/07/30
Concluído
PhD in Pharmacology (Doctor of Philosophy)
University of London, Reino Unido
"Mechanistic pathways underlying familial Parkinson’s disease caused by leucine-rich repeat kinase 2 mutations" (TESE/DISSERTAÇÃO)
2005/07/30
Concluído
BSc Hon Genetics (Bachelor)
Newcastle University, Reino Unido
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2023/10/01 - Atual Gestão de Ciência e Tecnologia Universidade de Coimbra, Portugal
2023/06/21 - 2023/12/20 Gestão de Ciência e Tecnologia The Francis Crick Institute, Reino Unido
2012/07/01 - 2023/06/21 Gestão de Ciência e Tecnologia Alzheimer's Research UK, Reino Unido
2009/10/01 - 2012/06/30 Pós-doutorado (Investigação) King's College London, Reino Unido
Projetos

Bolsa

Designação Financiadores
2009/10/01 - 2012/06/30 MITOTARGET (Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics)
Investigador Pós-doutorado

Projeto

Designação Financiadores
2023/09/01 - 2027/12/31 Multidisciplinary Institute of Ageing - Portugal
857524
Bolseiro de Gestão de Ciência e Tecnologia
Universidade de Coimbra, Portugal
European Commission
Em curso
2005/10/01 - 2009/09/30 Physiological and pathological role of the Parkinson’s disease protein LRRK2
Unknown
Bolseiro de Doutoramento
Produções

Publicações

Artigo em revista
  1. Andreou, Melina; Choi, Narshil; Magenti, Jorge Gómez; Kohlhaas, Susan; Sancho, Rosa. "The dementia research career pipeline: Gender disparities in publication authorships and grant funding outcomes at different career stages". Health Open Research 4 (2022): 18. http://dx.doi.org/10.12688/amrcopenres.13072.1.
    10.12688/amrcopenres.13072.1
  2. Meyers, Emily A.; Amouyel, Philippe; Bovenkamp, Diane E.; Carrillo, Maria C.; De Buchy, Geraldine Drexel; Dumont, Magali; Fillit, Howard; et al. "Commentary: Global Alzheimer's disease and Alzheimer's disease related dementia research funding organizations support and engage the research community throughout the COVID-19 pandemic". Alzheimer's & Dementia 18 5 (2021): 1067-1070. http://dx.doi.org/10.1002/alz.12472.
    10.1002/alz.12472
  3. Snyder, Heather M.; Shineman, Diana W.; Friedman, Lauren G.; Hendrix, James A.; Khachaturian, Ara; Le Guillou, Ian; Pickett, James; et al. "Guidelines to improve animal study design and reproducibility for Alzheimer's disease and related dementias: For funders and researchers". Alzheimer's & Dementia 12 11 (2016): 1177-1185. http://dx.doi.org/10.1016/j.jalz.2016.07.001.
    10.1016/j.jalz.2016.07.001
  4. Mitchell, S.; Ridley, S.H.; Sancho, R.M.; Norton, M.. "The future of dementia risk reduction research: barriers and solutions". Journal of Public Health (2016): http://dx.doi.org/10.1093/pubmed/fdw103.
    10.1093/pubmed/fdw103
  5. Sancho, Rosa M.; Cox, Carla J.; Phipps, Laura E.; Ridley, Simon H.. "Alzheimer’s Research UK 2016 Conference report". Alzheimer's Research & Therapy 8 1 (2016): http://dx.doi.org/10.1186/s13195-016-0203-0.
    10.1186/s13195-016-0203-0
  6. Stoica, Radu; Paillusson, Sébastien; Gomez-Suaga, Patricia; Mitchell, Jacqueline C; Lau, Dawn HW; Gray, Emma H; Sancho, Rosa M; et al. "<scp>ALS</scp> / <scp>FTD</scp> -associated <scp>FUS</scp> activates <scp>GSK</scp> -3ß to disrupt the <scp>VAPB</scp> – <scp>PTPIP</scp> 51 interaction and <scp>ER</scp> –mitochondria associations". EMBO reports 17 9 (2016): 1326-1342. http://dx.doi.org/10.15252/embr.201541726.
    10.15252/embr.201541726
  7. Sancho, Rosa M.; Cox, Carla J.; Ridley, Simon H.; Phipps, Laura E.; Karran, Eric. "Report from the Alzheimer’s Research UK Conference 2015". Alzheimer's Research &amp; Therapy 7 1 (2015): http://dx.doi.org/10.1186/s13195-015-0138-x.
    10.1186/s13195-015-0138-x
  8. Godena, Vinay K.; Brookes-Hocking, Nicholas; Moller, Annekathrin; Shaw, Gary; Oswald, Matthew; Sancho, Rosa M.; Miller, Christopher C. J.; Whitworth, Alexander J.; De Vos, Kurt J.. "Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms6245.
    10.1038/ncomms6245
  9. Stoica, Radu; De Vos, Kurt J.; Paillusson, Sébastien; Mueller, Sarah; Sancho, Rosa M.; Lau, Kwok-Fai; Vizcay-Barrena, Gema; et al. "ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms4996.
    10.1038/ncomms4996
  10. Law, Bernard M.H.; Spain, Victoria A.; Leinster, Veronica H.L.; Chia, Ruth; Beilina, Alexandra; Cho, Hyun J.; Taymans, Jean-Marc; et al. "A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific ß-Tubulin Isoforms Regulates Tubulin Acetylation". Journal of Biological Chemistry 289 2 (2014): 895-908. http://dx.doi.org/10.1074/jbc.m113.507913.
    10.1074/jbc.m113.507913
  11. Sancho, Rosa M.; Law, Bernard M.H.; Harvey, Kirsten. "Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways". Human Molecular Genetics 18 20 (2009): 3955-3968. http://dx.doi.org/10.1093/hmg/ddp337.
    10.1093/hmg/ddp337
Atividades

Arbitragem científica em conferência

Nome da conferência Local da conferência
2015 - 2023 Alzheimer's Research UK Conference

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2023 Regular dementia research expert in UK press from 2015 to 2023

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2023/01/01 - 2023/06/30 UK Ageing Research Funders Forum
Membro
2021 - 2023 AMRC Equality, Diversity and Inclusion working group
Membro
2021/01/01 - 2022/12/31 UK Government’s Bureaucracy Review Funders Panel
Membro
2020 - 2022 AMRC Open Research Advisory Board
Membro
2017 - 2022 NIHR Impact Advisory Board
Membro
2016 - 2018 International Alzheimer’s Disease Research Funders Consortium
Coordenador
2014 - 2017 Dementia Research Funders Forum
Membro