???global.info.a_carregar???
Yvonne Azasi completed the PhD in Immunology and Infection Research in 2016/11/29 by The University of Edinburgh College of Science and Engineering and Bachelor in Biochemistry in 2010/05/15 by University of Ghana. She is an Assistant Researcher at Fundação GIMM - Gulbenkian Institute for Molecular Medicine, formerly iMM, where she coordinates 2 projects. She has published 5 articles in journals (4 as first/co-first author) and 2 book chapters. She was awarded an FCT Exploratory grant in 2022, a Stimulus to Individual Scientific Employment (CEEC) in 2024 and an FCT RESTART grant in 2025. She has organized 2 events and participated in 3 events. She has supervised 2 MSc dissertations and is currently supervising another MSc thesis. She has also co-supervised 2 works of course completion of BSc. She has received 9 awards and/or honors. She works in the areas of Medical and Health Sciences, and Natural sciences with emphasis on Parasitology, Biochemistry, Cell Biology and Molecular Biology.
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Yvonne Azasi

Nomes de citação

  • Azasi, Yvonne
  • Azasi, Y

Identificadores de autor

Ciência ID
DB19-4FBF-A3E9
ORCID iD
0000-0002-4993-8046

Endereços de correio eletrónico

  • yvonne.azasi@medicina.ulisboa.pt (Profissional)

Telefones

Telefone
  • 217999411 Ext.: 47343 (Profissional)

Moradas

  • Av. Professor Egas Moniz, Edifício Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde - Parasitologia
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Akan (Idioma materno)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Português Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A2)
Formação
Grau Classificação
2012/09/01 - 2016/11/29
Concluído
 Evolutionary Biology, Immunology and Infection Research (Doctor of Philosophy)
Especialização em Immunology And Infection Research
The University of Edinburgh College of Science and Engineering, Reino Unido
"Plasmodium falciparum binding interactions with human brain endothelial cells" (TESE/DISSERTAÇÃO)
2005/08/08 - 2010/05/15
Concluído
 Biochemistry (Bachelor)
Especialização em Biochemistry
University of Ghana, Gana
"Antioxidant activity of Piper guineense" (TESE/DISSERTAÇÃO)
 First Class Honours
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/07/01 - Atual Investigador Auxiliar (carreira) (Investigação) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2020/09/01 - 2024 Pós-doutorado (Investigação) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2017/01/02 - 2020/05/31 Pós-doutorado (Investigação) National Institute of Allergy and Infectious Diseases Laboratory of Malaria and Vector Research, Estados Unidos
National Institutes of Health, Estados Unidos
2011/11/01 - 2012/08/31 Assistente de Investigação (carreira) (Investigação) University of Ghana Noguchi Memorial Institute for Medical Research, Gana
University of Ghana Noguchi Memorial Institute for Medical Research, Gana

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/09/09 - 2016/12/16 Assistente (Docente Universitário) The University of Edinburgh - Biology Teaching Organization, Reino Unido
The University of Edinburgh School of Biological Sciences, Reino Unido
2010/08/01 - 2011/08/31 Assistente (Docente Universitário) University of Ghana, Gana
University of Ghana Department of Biochemistry, Cell and Molecular Biology, Gana

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/11/30 - 2016/03/31 Laboratory technician The University of Edinburgh - Biology Teaching Organization, Reino Unido
The University of Edinburgh School of Biological Sciences, Reino Unido
Projetos

Bolsa

Designação Financiadores
2022/05/05 - 2024 Parasite exploitation of host immune complement system during malaria infection
EXPL/SAU-PAR/1426/2021
Investigador responsável
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Instituto de Medicina Molecular João Lobo Antunes
LA/P/0082/2020
10.54499/LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/09/01 - 2022/05/16 Plasmodium cross-stage interplay modulates Severe Malaria pathology
PTDC/MED-IMU/28664/2017
Investigador Pós-doutorado
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. McLean, Florence E.; Azasi, Yvonne; Sutherland, Cameron; Toboh, Emmanuel; Ansong, Daniel; Agbenyega, Tsiri; Awandare, Gordon; Rowe, J. Alexandra. "Detection of naturally acquired, strain-transcending antibodies against rosetting Plasmodium falciparum strains in humans". Infection and Immunity 92 7 (2024): https://doi.org/10.1128/iai.00015-24.
    10.1128/iai.00015-24
  2. Azasi, Yvonne; Low, Leanne M.; Just, Ashley N.; Raghavan, Sai S. R.; Wang, Christian W.; Valenzuela-Leon, Paola; Rowe, J. Alexandra; et al. "Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence". Proceedings of the National Academy of Sciences 118 22 (2021): http://dx.doi.org/10.1073/pnas.2104166118.
    Acesso aberto • 10.1073/pnas.2104166118
  3. Azasi, Yvonne; Gallagher, Shannon K.; Diouf, Ababacar; Dabbs, Rebecca A.; Jin, Jing; Mian, Syed Yusuf; Narum, David L.; et al. "Bliss' and Loewe's additive and synergistic effects in Plasmodium falciparum growth inhibition by AMA1-RON2L, RH5, RIPR and CyRPA antibody combinations". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-67877-8.
    Acesso aberto • Publicado • 10.1038/s41598-020-67877-8
  4. Low, Leanne M.; Azasi, Yvonne; Sherling, Emma S.; Garten, Matthias; Zimmerberg, Joshua; Tsuboi, Takafumi; Brzostowski, Joseph; et al. "Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake". mBio 10 4 (2019): http://dx.doi.org/10.1128/mbio.01460-19.
    Acesso aberto • Publicado • 10.1128/mbio.01460-19
  5. Azasi, Yvonne; Lindergard, Gabriella; Ghumra, Ashfaq; Mu, Jianbing; Miller, Louis H.; Rowe, J. Alexandra. "Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function". Proceedings of the National Academy of Sciences 115 5 (2018): 1063-1068. http://dx.doi.org/10.1073/pnas.1712879115.
    Acesso aberto • Publicado • 10.1073/pnas.1712879115
Capítulo de livro
  1. Azasi, Yvonne. "Assay of Static Adhesion of Plasmodium falciparum-Infected Erythrocytes to Cells, Including Inhibition of the Adhesion". In Malaria Immunology; targeting the surface of infected erythrocytes, 515-525. Springer Nature, 2022.
    Publicado • 10.1007/978-1-0716-2189-9_39
  2. Azasi, Yvonne; Rowe, J. Alexandra. "Selecting Plasmodium falciparum Infected Erythrocytes for Adhesion to Cell Lines". In Malaria Immunology; targeting the surface of infected erythrocytes, 91-100. Springer Nature, 2022.
    Publicado • 10.1007/978-1-0716-2189-9_9
Poster em conferência
  1. Azasi, Yvonne; Maria Manuel Mota. Autor correspondente: Maria Manuel Mota. "Transcription factors as key regulators of Plasmodium nutrient sensing and virulence". Trabalho apresentado em Gordon Research Conference on Malaria, 2023.
  2. Azasi, Yvonne; Mota, Maria M.; Rowe, J. Alexandra. Autor correspondente: Azasi, Yvonne. "Parasite exploitation of host immune complement C1s during malaria infection". Trabalho apresentado em Gordon Research Seminar on Malaria, 2023.
  3. Azasi, Yvonne; Draper, Simon J.; Miura, Kazutoyo; Miller, Louis H.. "Evaluating the efficacy of AMA1-RON2, RH5, RIPR and CyRPA antibody combinations in inhibiting growth of P. falciparum". Trabalho apresentado em The American Society of Tropical Medicine and Hygiene 67th Annual Meeting, 2018.
  4. Azasi, Yvonne; Rowe, J. Alexandra. "Lack of evidence to support EPCR as a major cytoadherence receptor". Trabalho apresentado em Gordon Research Conference on Malaria, 2015.
  5. Azasi, Yvonne; Rowe, J. Alexandra. "Adhesion properties of P. falciparum infected erythrocytes that bind human brain endothelial cells and the role of EPCR". Trabalho apresentado em 10th Annual BioMalPar-EVIMalaR Conference, 2014.

Outros

Outra produção
  1. Detection of naturally acquired, strain-transcending antibodies against rosetting Plasmodium falciparum strains in humans. 2024. McLean, F.E.; Azasi, Y.; Sutherland, C.; Toboh, E.; Ansong, D.; Agbenyega, T.; Awandare, G.; Rowe, J.A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85186091186&partnerID=MN8TOARS.
    10.1101/2024.01.11.575252
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/07/23 Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence WACCBIP Research Conference
West African Centre for Cell Biology of Infectious Pathogens Research (WACCBIP) (Legon, Gana)
2016/04/13 The role of DC8 and 13 PfEMP1 domains in cytoadhesion of Plasmodium falciparum to human brain endothelial cells From Science to Solutions: optimising control of parasitic diseases
British Society For Parasitology (London, Reino Unido)
2015/07/26 Lack of evidence to support EPCR as a major cytoadherence receptor Translating Malaria Research to the Field
Malaria Gordon Research Seminar (Girona, Espanha)
2015/05/06 Plasmodium falciparum binding interactions with human brain endothelial cells Institute of Immunology and Infection Research Postgraduate Symposium
Institute of Immunology and Infection Research (Edinburgh, Reino Unido)
2015/04/16 Lack of evidence to support EPCR as a major cytoadherence receptor Malaria, Neglected Tropical Diseases (NTDs) and their Vectors
British Society For Parasitology (Liverpool, Reino Unido)
2014/04/07 Adhesion properties of P. falciparum infected erythrocytes that bind human brain endothelial cells British Society for Parasitology Annual Spring meeting
British Society For Parasitology (Cambridge, Reino Unido)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/09/02 - Atual Transcriptional regulation of Plasmodium sensing of amino-acids
Orientador
 MESTRADO EM MICROBIOLOGIA APLICADA (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/01 - 2024/02 Measuring activated complement component 1s (C1s) levels in plasma samples and the effect of temperature and time on activated C1s during storage
Orientador
 Masters in Biomedical Sciences (Mestrado)
Rijksuniversiteit Groningen, Países Baixos
2022/03 - 2022/04 Transcription factors as regulators of nutrient sensing in Plasmodium
Orientador
 Mestrado Integrado em Medicina (Mestrado)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2015 - 2015 Plasmodium falciparum interactions with human brain endothelial cells in cerebral malaria
Coorientador
 Biological Sciences (Licenciatura/Bacharelato)
The University of Edinburgh, Reino Unido
2014 - 2014 Spontaneous rosette formation in uncomplicated and severe malaria infections in Ghana
Coorientador
 Biochemistry, Cell and Molecular Biology (Licenciatura/Bacharelato)
University of Ghana Department of Biochemistry, Cell and Molecular Biology, Gana

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2016/11 - 2016/12/08 Facilitator for A Question of Taste: PCR workshop for senior secondary school pupils (2016/11/10 - 2016/12/08)
Oficina (workshop) (Outra)
 The University of Edinburgh, Reino Unido
2016/03/31 - 2016/04/01 Volunteer at Immunology and Microscopy Stand at the Edinburgh International Science Festival. Assisted the public in games and microscope viewing of samples to learn about immunology. (2016/03/31 - 2016/04/01)
Festival (Outra)
 The University of Edinburgh School of Biological Sciences, Reino Unido

National Museum of Scotland, Reino Unido
2013/01/28 - 2013/03/31 SCI-FUN Roadshow : Hands-on Science, Technology, Engineering, and Mathematics (STEM) activities to S1/S2 pupils (2013/01/28 - 2013/03/31)
Exposição (Outra)
 The University of Edinburgh, Reino Unido

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/04/05 - 2022/04/07 Leadership and Management Skills Course for Postdocs
Oficina (workshop)
hfp consulting, Alemanha
2013/06/11 - 2013/06/13 Cell based assays for screening: 3 day practical workshop
Oficina (workshop)
 Cell based assays for screening
European ScreeningPort, Alemanha

European Pharmaceutical Review, Reino Unido

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2014/09/01 - 2016/11/30 The Dynamic Cell 2 Tutorials and Laboratory Practicals The Dynamic Cell 2 (Bachelor) The University of Edinburgh - Biology Teaching Organization, Reino Unido
2013/09/09 - 2016/11/30 Origin and Diversity of Life 1 Laboratory Practicals Origin and Diversity of Life 1 (Bachelor) The University of Edinburgh - Biology Teaching Organization, Reino Unido
2014/01/06 - 2016/03/31 Molecules, Genes and Cells 1 Laboratory Practicals Molecules, Genes and Cells 1 The University of Edinburgh - Biology Teaching Organization, Reino Unido
2015/10/15 - 2015/11/26 Parasite Biology 3 Laboratory Practicals Parasite Biology 3 (Bachelor) The University of Edinburgh - Biology Teaching Organization, Reino Unido

Expedição científica

Descrição da atividade Instituição / Organização
2014/05/01 - 2014/07/31 I collaborated with Prof. Gordon Awandare at the University of Ghana to organize a field project to collect and characterize blood samples from children diagnosed with uncomplicated and severe malaria in three hospitals in Ghana. I successfully collected approximately 120 samples in 3 months. These samples have been useful in on-going studies in the Rowe lab (University of Edinburgh) and in my C1s in Malaria project. University of Ghana Department of Biochemistry, Cell and Molecular Biology, Gana

University of Ghana Noguchi Memorial Institute for Medical Research, Gana

Membro de associação

Nome da associação Tipo de participação
2012/03/21 - Atual American Society for Microbiology Postdoctoral Membership
2017/07/01 - 2019/06/30 American Society of Tropical Medicine and Hygiene Postdoctoral Membership
2014/01/24 - 2017/01/07 British Society for Parasitology

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2019 - Atual Journal of Tropical Medicine Hindawi
2018/03/09 - Atual Malaria Journal (1475-2875) BioMed Central

Tutoria

Tópico Nome do aluno
2022/11/08 - 2022/12/23 Transcription factors involved in methionine sensing in Plasmodium spp Ana Marta Ferreira Baião
2022/05/09 - 2022/06/03 AP2 as the link between nutrient sensing and replicative fitness in Plasmodium blood-stage infection Rodrigo G. Q. Fernandes
Distinções

Prémio

2016 Meeting Travel Award
The British Society for Parasitology, Reino Unido
2015 Conference and Advanced Course Grant
The Darwin Trust of Edinburgh, Reino Unido
2015 James Rennie Bequest Travel Prize
The University of Edinburgh School of Biological Sciences, Reino Unido
2015 Meeting Travel Award
The British Society for Parasitology, Reino Unido
2015 Travel Award
Gordon Research Conferences, Estados Unidos
2014 James Rennie Bequest Travel Prize
The University of Edinburgh School of Biological Sciences, Reino Unido
2014 Meeting Travel Award
The British Society for Parasitology, Reino Unido
2012 The Darwin Trust of Edinburgh Postgraduate Scholarship
The Darwin Trust of Edinburgh, Reino Unido

Outra distinção

2024 Concurso Estímulo ao Emprego Científico Individual (CEEC) 5th Edition - Assistant Researcher
Fundação para a Ciência e a Tecnologia, Portugal