???global.info.a_carregar???
Rodrigo Cunha is a Full Professor at the Faculty of Medicine where he heads the Institute of Biochemistry and he is a Principal Investigator at the Institute for Clinical and Biomedical Research (iCBR). He is part of the Steering Committee of the European Neuroscience Campus, the National representative of the Network of European Neuroscience Institutes and a scientific consultant of the Association for Scientific Information on Coffee (ASIC). He heads the group ‘Purines at UC’, focusing on caffeine neuroprotection and purinergic modulation; his group is constituted by 5 resident PhD researchers, 3 post-docs and 4 PhD students. He has published over 300 papers with an h factor of 87. He has trained over 40 PhD students and 20 post-doctoral fellows and attracted funds from American and European agencies and private companies.
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Rodrigo Antunes Cunha

Nomes de citação

  • Cunha, Rodrigo A.

Identificadores de autor

Ciência ID
CF1A-8BED-B840
ORCID iD
0000-0003-2550-6422
Researcher Id
E-7475-2015
Scopus Author Id
7102879525

Moradas

  • iCBR - Instituto de Investigação Clínica e Biomédica, Campus das Ciências da Saúde, Polo III, Faculdade de Medicina, Universidade de Coimbra, 3004-548, Coimbra, Coimbra, Portugal (Profissional)
  • FMUC, Instituto de Bioquímica, Unidade Central, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B2) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B2) Utilizador independente (B1)
Italiano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
2008/12 - 2008/12
Concluído
 Biomedicina (Especialização pós-licenciatura)
Especialização em Fisiologia do Envelhecimento
Universidade de Coimbra Faculdade de Medicina, Portugal
 aprovado por unanimidade
1995/01 - 1996/09
Concluído
 Neurosciences (Pós-doutoramento)
Especialização em Neuropharmacology
Karolinska Institutet, Suécia
1994/03 - 1994/12
Concluído
 Clinical Research Associate (Licence)
Rhône-Poulenc Rorer, França
 aprovado
1990/01 - 1994/07
Concluído
 Bioquímica (Doutoramento)
Especialização em Farmacologia
Universidade de Lisboa Faculdade de Ciências, Portugal
"Origem e Função Neuromoduladora da Adenosina no Sistema Nervoso" (TESE/DISSERTAÇÃO)
 distinção e louvor
1984/10 - 1989/06
Concluído
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Caracterização do catabolismo extracelular de nucleótidos de adenina na junção neuromuscular de rã" (TESE/DISSERTAÇÃO)
 17 / 20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento		 Empregador
1995/03 - 1996/09 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
1991/01 - 1993/12 Estagiário de Investigação (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Gulbenkian de Ciência, Portugal
1989/09 - 1990/12 Estagiário de Investigação (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento		 Empregador
2019/09 - Atual Professor Catedrático (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2004/03 - 2019/08 Professor Associado (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2001/03 - 2004/03 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
1996/10 - 2001/02 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento		 Empregador
1994/04 - 1995/02 Clinical Research Associate Rhône-Poulenc Rorer, França
Rhône-Poulenc Rorer, França
Projetos

Bolsa

Designação Financiadores
2018/01 - 2019/12 Manipulação dos receptores A2A da adenosina para controlar os sintomas do síndrome de Angelman
2017
 Fundação Amélia de Mello
2014/03 - 2015/09 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
Provided by PTCRIS: 135805
 Fundação para a Ciência e a Tecnologia, I.P.
2012/04 - 2014/09 Role of accumbens and amygdala in the control of chronic stress neuropathology
Provided by PTCRIS: 122254
 Fundação para a Ciência e a Tecnologia, I.P.
2012/05 - 2014/08 Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection
Provided by PTCRIS: 122005
 Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/09 Role of ATP and its P2Y1 receptors in neuroprotection
Provided by PTCRIS: 100423
 Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/02 Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage
Provided by PTCRIS: 108668
 Fundação para a Ciência e a Tecnologia, I.P.
2007/05 - 2010/04 Interaction between nicotine and caffeine in the striatum. Relevance for Parkinson´s disease
Provided by PTCRIS: 81064
 Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2009/10 EFFECT OF PURINES IN THE DEVELOPING HIPPOCAMPUS: CONSEQUENCES FOR THE ESTABLISHMENT OF CIRCUITS RELATED TO LEARNING AND MEMORY
Provided by PTCRIS: 74318
 Fundação para a Ciência e a Tecnologia, I.P.
2007/06 - 2009/08 Role of extracellular ATP and characterization of purinergic receptors in the resistance of Candida albicans to macrophage attack
Provided by PTCRIS: 81436
 Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2008/01 Relation between metabolic alterations in the hippocampus and memory deficits induced by diabetes
Provided by PTCRIS: 56098
 Fundação para a Ciência e a Tecnologia, I.P.
2005/10 - 2007/12 Modification by chronic caffeine consumption of adenosine neuromodulation in the hippocampus - possible relevance for learning and memory
Provided by PTCRIS: 59601
 Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 Characterization of purinergic receptors in hippocampal mossy fibers - role in epilepsy
Provided by PTCRIS: 59135
 Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 Control by adenosine of neuro-inflammation
Provided by PTCRIS: 59980
 Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 NEUROPROTECTION BY ADENOSINE RECEPTORS: COUPLING ENHANCED ADENOSINE FORMATION WITH A2A RECEPTOR BLOCKADE
Provided by PTCRIS: 59215
 Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2025/05/01 - 2028/04/30 Exploiting the adenosine modulation system to control memory performance and Alzheimer’s disease
COMPETE2030-FEDER-0067630
Investigador responsável
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2026/02/01 - 2027/07/01 A new nutraceutical formulation to prevent stress-induced cognitive deterioration
CENTRO2030-2024-59
Investigador responsável
Universidade de Coimbra, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Em curso
2025/01/03 - 2026/02/28 VNUT: a new target and biomarker for Alzheimer’s disease
2023.13319.PEX
Investigador Pós-doutorado
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/05/01 - 2024/12/31 Strategies for healthy aging
CENTRO-01-0246-FEDER-000010
Investigador responsável
Universidade de Coimbra, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluído
2019/12 - 2022/12 Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress
LCF/PR/HP17/52190001
Investigador responsável
Universidade de Coimbra, Portugal
 Caixabank SA
Em curso
2020/01 - 2022/09 Adenosine A2A receptor antagonism affords integrated benefits for neurological symptoms of neurofibromatosis type I
W81XWH-18-1-0532NF170062
Investigador responsável
Universidade de Coimbra, Portugal
 Congressionally Directed Medical Research Programs
Em curso
2018/05 - 2022/06 Strategies for healthy aging
CENTRO-01-0246-FEDER-000010
Universidade de Coimbra, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Em curso
2020/01/01 - 2022/04/01 MIA-Portugal Multidisciplinary Institute of Ageing
857524
Investigador responsável
Universidade de Coimbra, Portugal
Em curso
2018/07/01 - 2021/06/30 Recetores A2A da adenosina como desencadeadores de disfunção mnemónica na doença de Alzheimer: mecanismos e possibilidade terapêutica
PTDC/MED-NEU/31274/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07 - 2021/06 Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer’s disease: mechanisms and therapeutic propects
POCI-01-0145-FEDER-031274
Investigador responsável
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/05 - 2019/06 Role of astrocytes in the control of memory – focus on adenosine A2A receptors
PTDC/NEU-NMC/4154/2014
 Fundação para a Ciência e a Tecnologia
2014/10 - 2018/03 Role des récepteurs de l'adénosine dans la stabilisation des synapses
ANR-14-CE13-0032
 Agence nationale de la recherche
2016/03 - 2017/08 Adenosine A2A receptors controls non-motor (mood and cognitive) symptoms in Parkinson’s disease
CAPES-FCT 8543/2014-03
 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
2013/09 - 2017/05 Role of adenosine A2A receptors in the control of synaptic plasticity in the prefrontal cortex – relevance for attention deficit and hyperactivity disorders
159302-1-2009-1-NL-ERA MUNDUS-EMJD
 European Commission
2014/10 - 2016/06 ROLE OF ADENOSINE A2A RECEPTORS IN THE ACCUMBENS AND AMYGDALA IN THE CONTROL OF CHRONIC STRESS NEUROPATHOLOGY
NARSAD Independent Investigator Grant
Investigador responsável
Universidade de Coimbra, Portugal
 Brain and Behavior Research Foundation
Concluído
2014/03/01 - 2015/09/30 Ageing@Coimbra: Um Centro de Co-localização na Rede Europeia de Conhecimento e Inovação para o Envelhecimento Saudável e Ativo
EIT-KIC/IVE/0043/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/04/01 - 2014/09/30 Papel do accumbens e amigdala no controlo da neuropatologia causada por stress crónico
PTDC/SAU-NSC/122254/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/05/01 - 2014/08/31 Papel fisio-patológico da ecto-5`-nucleotidase - um novo alvo para neuroprotecção
PTDC/SAU-TOX/122005/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/03/18 - 2012/09/17 Papel do ATP e dos seus receptores P2Y1 na neuroprotecção
PTDC/SAU-FCF/100423/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em jornal
  1. Wu Zheng; Lanxin Hu; Yuwen Yang; Xuhang Li; Jia Wu; Wangchao Chen; Yiwei Jiang; et al. "Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus", 2025
    10.1038/s41467-025-66776-8
  2. Lopes, Cátia R.; Cunha, Rodrigo A.. "Impact of coffee intake on human aging: Epidemiology and cellular mechanisms", The conception of coffee consumption has undergone a profound modification, evolving from a noxious habit into a safe lifestyle actually preserving human health. The last 20 years also provided strikingly consistent epidemiological evidence showing that the regular consumption of moderate doses of coffee attenuates all-cause mortality, an effect observed in over 50 studies in different geographic , 2024
    10.1016/j.arr.2024.102581
  3. Köfalvi, Attila; Sánchez-Fernández, Nuria; Gómez Acero, Laura; Castañé, Anna; Adell, Albert; Campa, Leticia; Bonaventura, Jordi; et al. "A combination of ¿9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer's disease", A combination of ¿9-tetrahydrocannabinol (¿9-THC) and cannabidiol (CBD) at non-psychoactive doses was previously demonstrated to reduce cognitive decline in APP/PS1 mice, an animal model of Alzheimer's disease (AD). However, the neurobiological substrates underlying these therapeutic properties of ¿9-THC and CBD are not fully understood. Considering that dysregulation of glutamatergic activity con, 2024
    10.1016/j.neurot.2024.e00439
  4. Xiaoting Sun; Liliana Dias; Chenlei Peng; Ziyi Zhang; Haoting Ge; Zejun Wang; Jiayi Jin; et al. "40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice", <jats:title>Abstract</jats:title> <jats:p> The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain parenchyma and eliminates metabolic waste. Animal and human studies have uncovered several important physiological factors regulating the glymphatic, 2024
    10.1038/s41421-024-00701-z
  5. Jorge Lindo; Célia Nogueira; Rui Soares; Nuno Cunha; Maria Rosário Almeida; Lisa Rodrigues; Patrícia Coelho; et al. "Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection", <jats:p>SARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic and ge, 2024
    10.3390/ijms25116135
  6. Ana Cristina de Bem Alves; Naiara de Souza Santos; Ana Paula Tavares Santos; Gabriela da Panatta; Ana Elisa Speck; Rodrigo A. Cunha; Aderbal S. Aguiar. "Adenosine A2A and dopamine D2 receptor interaction controls fatigue resistance", <jats:p><jats:bold>Introduction:</jats:bold> Caffeine and the selective A<jats:sub>2A</jats:sub> receptor antagonist SCH58261 both have ergogenic properties, effectively reducing fatigue and enhancing exercise capacity. This study investigates in male Swiss mice the interaction between adenosine A<jats:sub>2A</jats:sub> receptors and dopamine D<jats:sub>2</jats:sub> receptors controlling central f, 2024
    10.3389/fphar.2024.1390187
Artigo em revista
  1. Sofia C. Valladão; Cátia R. Lopes; João Pedro Lopes; Madalena Piteira; Pablo Pandolfo; Alexandre Santos-Rodrigues; Paula Agostinho; et al. "Similar adenosine neuromodulation in male and female hippocampal and prefrontocortical synapses of young and aged mice". Neuroscience Letters (2025): https://doi.org/10.1016/j.neulet.2025.138306.
    10.1016/j.neulet.2025.138306
  2. Tyciane de Souza Nascimento; Alfaete Vieira Oliveira; Mônica de Oliveira Bélem; Jéssica Rabelo Bezerra; Marta Regina Santos do Carmo; Mateus Edson da Silva; Rodrigo A. Cunha; et al. "The Rotenone-Induced Sporadic Parkinsonism Model: Timeline of Motor and Non-Motor Features". European Journal of Neuroscience (2025): https://doi.org/10.1111/ejn.16669.
    10.1111/ejn.16669
  3. Samira G. Ferreira; Rafael M. Bitencourt; Pedro Garção; Rodrigo A. Cunha; Attila Köfalvi. "Comparing adenosine A2A receptor modulation of cannabinoid CB1 receptor-mediated inhibition of GABA and glutamate release in rodent striatal nerve terminals". European Journal of Neuroscience (2025): https://doi.org/10.1111/ejn.16642.
    10.1111/ejn.16642
  4. Liliana Dias; Ana Margarida Nabais; Vladimir P. P. Borges-Martins; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Impact of Glucocorticoid-Associated Stress-Like Conditions on Aquaporin-4 in Cultured Astrocytes and Its Modulation by Adenosine A2A Receptors". Journal of Neurochemistry (2025): https://doi.org/10.1111/jnc.16299.
    10.1111/jnc.16299
  5. Nuno J. Machado; Ana Paula Ardais; Ana Nunes; Eszter C. Szabó; Vasco Silveirinha; Henrique B. Silva; Manuella P. Kaster; Rodrigo A. Cunha. "Impact of Coffee Intake on Measures of Wellbeing in Mice". Nutrients (2024): https://doi.org/10.3390/nu16172920.
    10.3390/nu16172920
  6. Diogo M. da Fonseca; Lisa Rodrigues; José Sousa-Baptista; Félix Marcos-Tejedor; Marta Mota; Rodrigo A. Cunha; Chantal Fernandes; Teresa Gonçalves. "Caffeine Protects Keratinocytes from Trichophyton mentagrophytes Infection and Behaves as an Antidermatophytic Agent". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25158303.
    10.3390/ijms25158303
  7. Rodrigo A. Cunha; Francieli Rohden; Diogo O. Souza. "Instituto de pesquisa café e saúde: Prevenção de doenças e melhora da qualidade de vida". Research, Society and Development (2024): https://doi.org/10.33448/rsd-v13i5.45666.
    10.33448/rsd-v13i5.45666
  8. Ana Carla L. Nunes; Marta Carmo; Andrea Behrenswerth; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha. "Adenosine A2A Receptor Blockade Provides More Effective Benefits at the Onset Rather than after Overt Neurodegeneration in a Rat Model of Parkinson’s Disease". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25094903.
    10.3390/ijms25094903
  9. Zhou, Xuzhao; He, Yan; Xu, Tao; Wu, Zhaofa; Guo, Wei; Xu, Xi; Liu, Yuntao; et al. "40 Hz light flickering promotes sleep through cortical adenosine signaling". Cell Research (2024): http://dx.doi.org/10.1038/s41422-023-00920-1.
    Aceite para publicação • 10.1038/s41422-023-00920-1
  10. Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al. "The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". Molecular Psychiatry (2024): http://dx.doi.org/10.1038/s41380-024-02412-z.
    Aceite para publicação • 10.1038/s41380-024-02412-z
  11. Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata; Ana Paula Tavares; et al. "The striatum drives the ergogenic effects of caffeine". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-023-09922-5.
    10.1007/s11302-023-09922-5
  12. Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors". Cellular and Molecular Life Sciences (2023): https://doi.org/10.1007/s00018-023-04983-6.
    10.1007/s00018-023-04983-6
  13. Simões, Ana P.; Portes, Marina A. M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride L.; et al. "Adenosine A2A receptors control generalization of contextual fear in rats". Translational Psychiatry 13 1 (2023): http://dx.doi.org/10.1038/s41398-023-02613-0.
    Publicado • 10.1038/s41398-023-02613-0
  14. Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice". Glia (2023): https://doi.org/10.1002/glia.24384.
    10.1002/glia.24384
  15. Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease". Biomolecules (2023): https://doi.org/10.3390/biom13081173.
    10.3390/biom13081173
  16. Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda; et al. "Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest". Frontiers in Behavioral Neuroscience 17 (2023): http://dx.doi.org/10.3389/fnbeh.2023.1176382.
    Publicado • 10.3389/fnbeh.2023.1176382
  17. Pedro Valada; Sonja Hinz; Christin Vielmuth; Cátia R. Lopes; Rodrigo A. Cunha; Christa E. Müller; João Pedro Lopes. "The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-022-09899-7.
    10.1007/s11302-022-09899-7
  18. Fernandes, Mara Yone D.; Lopes, João Pedro; Silva, Henrique B.; Andrade, Geanne M.; Cunha, Rodrigo A.; Tomé, Angelo R.. "Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices". Neuroscience Letters 808 (2023): 137292. http://dx.doi.org/10.1016/j.neulet.2023.137292.
    Publicado • 10.1016/j.neulet.2023.137292
  19. Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation". Biomolecules (2023): https://doi.org/10.3390/biom13040715.
    10.3390/biom13040715
  20. Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences 24 8 (2023): 6968. http://dx.doi.org/10.3390/ijms24086968.
    Publicado • 10.3390/ijms24086968
  21. Wang, Muran; Li, Peijun; Li, Zewen; da Silva, Beatriz S.; Zheng, Wu; Xiang, Zhenghua; He, Yan; et al. "Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37601-x.
    Publicado • 10.1038/s41467-023-37601-x
  22. Gonçalves, Francisco Q.; Valada, Pedro; Matos, Marco; Cunha, Rodrigo A.; Tomé, Angelo R.. "Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals". Purinergic Signalling (2023): http://dx.doi.org/10.1007/s11302-023-09937-y.
    Aceite para publicação • 10.1007/s11302-023-09937-y
  23. Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; et al. "Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress". ACS Chemical Neuroscience 14 7 (2023): 1299-1309. http://dx.doi.org/10.1021/acschemneuro.2c00810.
    Publicado • 10.1021/acschemneuro.2c00810
  24. Jiang-Fan Chen; Doo-Sup Choi; Rodrigo A. Cunha. "Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility". Neuropharmacology (2023): https://doi.org/10.1016/j.neuropharm.2023.109421.
    10.1016/j.neuropharm.2023.109421
  25. Cátia R. Lopes; Andreia Oliveira; Ingride Luzio Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas". Biomolecules (2023): https://www.mdpi.com/2218-273X/13/1/106.
    10.3390/biom13010106
  26. Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-Pierre; et al. "Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease". Molecular Neurobiology 60 3 (2022): 1659-1674. http://dx.doi.org/10.1007/s12035-022-03162-1.
    Aceite para publicação • 10.1007/s12035-022-03162-1
  27. Dewaeles, Edmone; Carvalho, Ke´vin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan; et al. "Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects". Journal of Clinical Investigation 132 22 (2022): http://dx.doi.org/10.1172/jci152924.
    Publicado • 10.1172/jci152924
  28. Bruno Gonçalves Pinheiro; Diandra Araújo Luz; Sabrina de Carvalho Cartágenes; Luanna de Melo Pereira Fernandes; Sarah Viana Farias; Natália Harumi Correa Kobayashi; Enéas Andrade Fontes-Júnior; et al. "The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine". Pharmaceuticals (2022): https://doi.org/10.3390/ph15111323.
    10.3390/ph15111323
  29. Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Rodrigo A. Cunha. "CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232112826.
    10.3390/ijms232112826
  30. Pedro Valada; Sofia Alçada-Morais; Rodrigo A. Cunha; João Pedro Lopes. "Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231810510.
    10.3390/ijms231810510
  31. Xu, Xinli; Beleza, Rui O.; Gonçalves, Francisco Q.; Valbuena, Sergio; Alçada-Morais, Sofia; Gonçalves, Nélio; Magalhães, Joana; et al. "Adenosine A2A receptors control synaptic remodeling in the adult brain". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18884-4.
    Publicado • 10.1038/s41598-022-18884-4
  32. Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho. "Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04492-y.
    10.1007/s00018-022-04492-y
  33. Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; et al. "Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription". Journal of Clinical Investigation 132 12 (2022): http://dx.doi.org/10.1172/jci149371.
    Publicado • 10.1172/jci149371
  34. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas. "Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes". Purinergic Signalling (2022): https://doi.org/10.1007/s11302-022-09864-4.
    10.1007/s11302-022-09864-4
  35. Carvalho da Silva, António M.; Lemos, Cristina; Silva, Henrique B.; Ferreira, Ildete L.; Tomé, Angelo R.; Rego, A. Cristina; Cunha, Rodrigo A.. "Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.835885.
    Publicado • 10.3389/fnagi.2022.835885
  36. IJzerman, Adriaan P.; Jacobson, Kenneth A.; Müller, Christa E.; Cronstein, Bruce N.; Cunha, Rodrigo A.. "International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update". Pharmacological Reviews 74 2 (2022): 340-372. http://dx.doi.org/10.1124/pharmrev.121.000445.
    Publicado • 10.1124/pharmrev.121.000445
  37. Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré. "Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome". Molecules (2022): https://doi.org/10.3390/molecules27051489.
    10.3390/molecules27051489
  38. Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure". Journal of Neurochemistry (2022): https://doi.org/10.1111/jnc.15575.
    10.1111/jnc.15575
  39. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho. "Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-021-02538-z.
    10.1007/s12035-021-02538-z
  40. Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al. "Convergence of adenosine and GABA signaling for synapse stabilization during development". Science 374 6568 (2021): http://dx.doi.org/10.1126/science.abk2055.
    10.1126/science.abk2055
  41. Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, Marco; et al. "Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction". Neurobiology of Disease 157 (2021): 105441. http://dx.doi.org/10.1016/j.nbd.2021.105441.
    Publicado • 10.1016/j.nbd.2021.105441
  42. Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al. "l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory". The FASEB Journal 35 8 (2021): https://doi.org/10.1096/fj.202100336R.
    10.1096/fj.202100336R
  43. Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A.. "Adenosine A2A Receptors as Biomarkers of Brain Diseases". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.702581.
    10.3389/fnins.2021.702581
  44. Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto; Gonçalves, Teresa; Rodrigues, Lisa. "Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps Escape". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.678568.
    10.3389/fcimb.2021.678568
  45. Aguiar, Aderbal S.; Speck, Ana Elisa; Canas, Paula M.; Cunha, Rodrigo A.. "Deletion of CD73 increases exercise power in mice". Purinergic Signalling 17 3 (2021): 393-397. http://dx.doi.org/10.1007/s11302-021-09797-4.
    Publicado • 10.1007/s11302-021-09797-4
  46. Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães, Joana; et al. "Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation". Cerebral Cortex 31 12 (2021): 5652-5663. http://dx.doi.org/10.1093/cercor/bhab188.
    Publicado • 10.1093/cercor/bhab188
  47. Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A. A.; Porciúncula, Lisiane O.; et al. "Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-89964-0.
    10.1038/s41598-021-89964-0
  48. Lopes, Cátia R.; Cunha, Rodrigo A.; Agostinho, Paula. "Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.666710.
    10.3389/fnins.2021.666710
  49. Lopes, Cátia R.; Lourenço, Vanessa S.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula M.. "Use of knockout mice to explore CNS effects of adenosine". Biochemical Pharmacology 187 (2021): 114367. http://dx.doi.org/10.1016/j.bcp.2020.114367.
    Publicado • 10.1016/j.bcp.2020.114367
  50. Figueiredo, Amanda Braga; Oliveira e Castro, Renata Alves; Nogueira-Paiva, Nívia Carolina; Moreira, Filipa; Gonçalves, Francisco Queiroz; Soares, Rodrigo Pedro; Castro-Borges, William; et al. "Clustering of adenosine A<sub>2B</sub>receptors with ectonucleotidases in caveolin-rich lipid rafts underlies immunomodulation by<i>Leishmania amazonensis</i>". The FASEB Journal 35 5 (2021): http://dx.doi.org/10.1096/fj.202002396rr.
    Publicado • 10.1096/fj.202002396rr
  51. Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Ângelo R.; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D.. "Exercise decreases aberrant corticostriatal plasticity in an animal model of <scp>l</scp>-DOPA-induced dyskinesia". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320 4 (2021): R541-R546. http://dx.doi.org/10.1152/ajpregu.00295.2020.
    Publicado • 10.1152/ajpregu.00295.2020
  52. Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A.. "Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress". Frontiers in Cellular Neuroscience 15 (2021): http://dx.doi.org/10.3389/fncel.2021.639322.
    Publicado • 10.3389/fncel.2021.639322
  53. Cristiane do Socorro Ferraz Maia; Letícia Yoshitome Queiroz; Igor Gonçalves Oliveira; Carla Cristiane Soares Silva; Rodrigo A. Cunha; Deiweson Souza-Monteiro; Maria Karolina Martins Ferreira; et al. "Binge-Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood". Alcoholism: Clinical and Experimental Research 45 1 (2021): 56-63. https://doi.org/10.1111/acer.14501.
    10.1111/acer.14501
  54. Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02275-9.
    10.1007/s12035-020-02275-9
  55. Cunha, Rodrigo. "Control of glutamate release by complexes of adenosine and cannabinoid receptors". BMC Biology (2020): http://dx.doi.org/10.1186/s12915-020-0739-0.
    10.1186/s12915-020-0739-0
  56. Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome". Neurobiology of Disease 146 (2020): 105137-105137. https://doi.org/10.1016/j.nbd.2020.105137.
    10.1016/j.nbd.2020.105137
  57. Agostinho, Paula; Madeira, Daniela; Dias, Liliana; Simões, Ana Patrícia; Cunha, Rodrigo A.; Canas, Paula M.. "Purinergic signaling orchestrating neuron-glia communication". Pharmacological Research 162 (2020): 105253. http://dx.doi.org/10.1016/j.phrs.2020.105253.
    Publicado • 10.1016/j.phrs.2020.105253
  58. "Neuronal adenosine A2A receptors signal ergogenic effects of caffeine". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-69660-1.
    10.1038/s41598-020-69660-1
  59. de Santana Souza, Lisiane; de Siqueira, Priscila Albuquerque; Fernandes, Arlete; Silva Martins, Robertta; Cussa Kubrusly, Regina Célia; Paes-de-Carvalho, Roberto; Cunha, Rodrigo A.; dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo. "Role of Neuropeptide S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder". Neuroscience 448 (2020): 140-148. http://dx.doi.org/10.1016/j.neuroscience.2020.09.030.
    Publicado • 10.1016/j.neuroscience.2020.09.030
  60. Nehlig, Astrid; Cunha, Rodrigo. "The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation". Nutrients 12 10 (2020): 3141. http://dx.doi.org/10.3390/nu12103141.
    Publicado • 10.3390/nu12103141
  61. "Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats". Biomedicine & Pharmacotherapy 130 (2020): 110608-110608. http://dx.doi.org/10.1016/j.biopha.2020.110608.
    10.1016/j.biopha.2020.110608
  62. Matilde S. Rodrigues; Cláudia Ferreira; Cândida Dias; Anna Pliássova; Lisiane Souza; Ana Ledo; João Laranjinha; Rodrigo A. Cunha; Attila Köfalvi. "An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease". European Journal of Neuroscience (2020): https://doi.org/10.1111/ejn.14944.
    10.1111/ejn.14944
  63. Mack, Josiel Mileno; de Menezes Moura, Tainara; Bobinski, Franciane; Martins, Daniel Fernandes; Cunha, Rodrigo A.; Walz, Roger; Fernandes, Pedro Augusto; et al. "Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice". NeuroToxicology 80 (2020): 144-154. http://dx.doi.org/10.1016/j.neuro.2020.07.008.
    10.1016/j.neuro.2020.07.008
  64. Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo A.; Andrade, Geanne M.. "ATP Signaling Controlling Dyskinesia Through P2X7 Receptors". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.00111.
    Publicado • 10.3389/fnmol.2020.00111
  65. Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al. "Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes". Brain Research Bulletin 161 (2020): 106-115. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004.
    Publicado • 10.1016/j.brainresbull.2020.05.004
  66. França, Angela Patricia; Schamne, Marissa Giovanna; de Souza, Bruna Soares; da Luz Scheffer, Débora; Bernardelli, Angelica Karina; Corrêa, Thiago; de Souza Izídio, Geison; et al. "Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder". Molecular Neurobiology 57 9 (2020): 3902-3919. http://dx.doi.org/10.1007/s12035-020-02002-4.
    Publicado • 10.1007/s12035-020-02002-4
  67. Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Angelo R. Tomé; Cunha, Rodrigo A.; Ana M. Sebastião; Boison, Detlev. "Role of Adenosine in Epilepsy and Seizures". Journal of Caffeine and Adenosine Research 10 2 (2020): 45-60. http://dx.doi.org/10.1089/caff.2019.0022.
    10.1089/caff.2019.0022
  68. Pliássova, Anna; Henriques, Margarida; Silva, Henrique B.; Agostinho, Paula; Cunha, Rodrigo A.; Ferreira, Samira G.. "Control of NMDA Receptor-Mediated Currents by Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors Within the Basolateral Amygdala". Journal of Caffeine and Adenosine Research 10 2 (2020): 61-70. http://dx.doi.org/10.1089/caff.2019.0024.
    Publicado • 10.1089/caff.2019.0024
  69. Cunha, Rodrigo. "The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease". Purinergic Signalling (2020): http://dx.doi.org/10.1007/s11302-020-09694-2.
    10.1007/s11302-020-09694-2
  70. Cunha, Rodrigo. "Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: Brain region and sex specificities". European Journal of Neuroscience (2020): http://dx.doi.org/10.1111/ejn.14561.
    10.1111/ejn.14561
  71. Cunha, Rodrigo. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine". Neurobiology of Disease (2019): http://dx.doi.org/10.1016/j.nbd.2019.104570.
    10.1016/j.nbd.2019.104570
  72. Rodrigo A Cunha. "Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration". Brain (2019): https://doi.org/10.1093/brain/awz335.
    10.1093/brain/awz335
  73. Cunha, Rodrigo. "Purinergic signalling and brain development". Seminars in Cell & Developmental Biology (2019): http://dx.doi.org/10.1016/j.semcdb.2018.12.001.
    10.1016/j.semcdb.2018.12.001
  74. Sara L. Reis; Henrique B. Silva; Margarida Almeida; Rodrigo A. Cunha; Ana P. Simões; Paula M. Canas. "Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14816.
    10.1111/jnc.14816
  75. Cunha, Rodrigo. "Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A 2A receptor over-activation in a rat model of Parkinson's disease". British Journal of Pharmacology (2019): http://dx.doi.org/10.1111/bph.14771.
    10.1111/bph.14771
  76. Cunha, Rodrigo. "Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve". Molecules (2019): http://dx.doi.org/10.3390/molecules24162863.
    10.3390/molecules24162863
  77. João P. Lopes; Anna Pliássova; Rodrigo A. Cunha. "The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors". Biochemical Pharmacology 166 (2019): 313-321. https://doi.org/10.1016/j.bcp.2019.06.008.
    10.1016/j.bcp.2019.06.008
  78. Cunha, Rodrigo. "Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit and hyperactivity disorder". European Journal of Neuroscience (2019): http://dx.doi.org/10.1111/ejn.14348.
    10.1111/ejn.14348
  79. João Pedro Lopes; Rodrigo A. Cunha. "What is the extracellular calcium concentration within brain synapses?". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14696.
    10.1111/jnc.14696
  80. Cunha, Rodrigo. "Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors". Molecular Neurobiology (2019): http://dx.doi.org/10.1007/s12035-018-1296-1.
    10.1007/s12035-018-1296-1
  81. Rodrigo A. Cunha. "Signaling by adenosine receptors—Homeostatic or allostatic control?". PLOS Biology 17 4 (2019): e3000213-e3000213. https://doi.org/10.1371/journal.pbio.3000213.
    10.1371/journal.pbio.3000213
  82. Cunha, Rodrigo. "Treadmill Exercise Attenuates l-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice". Molecular Neurobiology (2019): http://dx.doi.org/10.1007/s12035-018-1278-3.
    10.1007/s12035-018-1278-3
  83. Xavier Morató; Francisco Q. Gonçalves; João P. Lopes; Olga Jauregui; Concepció Soler; Víctor Fernández-Dueñas; Rodrigo A. Cunha; Francisco Ciruela. "Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice". Journal of Neurochemistry 148 6 (2019): 796-809. https://doi.org/10.1111/jnc.14653.
    10.1111/jnc.14653
  84. Cunha, Rodrigo. "Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus". Frontiers in Neuroscience (2019): http://dx.doi.org/10.3389/fnins.2018.01015.
    10.3389/fnins.2018.01015
  85. Cunha, Rodrigo. "Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats". Glia (2019): http://dx.doi.org/10.1002/glia.23476.
    10.1002/glia.23476
  86. Cunha, Rodrigo. "G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum". Neural Regeneration Research (2019): http://dx.doi.org/10.4103/1673-5374.259610.
    10.4103/1673-5374.259610
  87. Cunha, Rodrigo. "Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making". Frontiers in Molecular Neuroscience (2018): http://dx.doi.org/10.3389/fnmol.2018.00475.
    10.3389/fnmol.2018.00475
  88. Aderbal S. Aguiar, Jr; Ana Elisa Speck; Inês M. Amaral; Paula M. Canas; Rodrigo A. Cunha. "The exercise sex gap and the impact of the estrous cycle on exercise performance in mice". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-29050-0.
    10.1038/s41598-018-29050-0
  89. Cunha, Rodrigo. "Promises of Caffeine in Attention-Deficit/Hyperactivity Disorder: From Animal Models to Clinical Practice". Journal of Caffeine and Adenosine Research (2018): http://dx.doi.org/10.1089/caff.2018.0016.
    10.1089/caff.2018.0016
  90. Cunha, Rodrigo. "Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions". eneuro (2018): http://dx.doi.org/10.1523/eneuro.0385-18.2018.
    10.1523/eneuro.0385-18.2018
  91. Cunha, Rodrigo. "Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation". Human Molecular Genetics (2018): http://dx.doi.org/10.1093/hmg/ddy264.
    10.1093/hmg/ddy264
  92. Cunha, Rodrigo. "Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats". Frontiers in Neuroscience (2018): http://dx.doi.org/10.3389/fnins.2018.00653.
    10.3389/fnins.2018.00653
  93. António C. Silva; Cristina Lemos; Francisco Q. Gonçalves; Anna V. Pliássova; Nuno J. Machado; Henrique B. Silva; Paula M. Canas; et al. "Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease". Neurobiology of Disease 117 (2018): 72-81. https://doi.org/10.1016/j.nbd.2018.05.024.
    10.1016/j.nbd.2018.05.024
  94. Cunha, Rodrigo. "Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats". Behavioural Brain Research (2018): http://dx.doi.org/10.1016/j.bbr.2018.05.007.
    10.1016/j.bbr.2018.05.007
  95. Cunha, Rodrigo. "Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors". Molecular Psychiatry (2018): http://dx.doi.org/10.1038/s41380-018-0110-9.
    10.1038/s41380-018-0110-9
  96. Cunha, Rodrigo. "Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex". European Journal of Neuroscience (2018): http://dx.doi.org/10.1111/ejn.13912.
    10.1111/ejn.13912
  97. Cunha, Rodrigo. "Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex". Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2018.00133.
    10.3389/fphar.2018.00133
  98. Cunha, Rodrigo. "Chronic coffee consumption and respiratory disease: A systematic review". The Clinical Respiratory Journal (2018): http://dx.doi.org/10.1111/crj.12662.
    10.1111/crj.12662
  99. Cunha, Rodrigo. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell Death & Disease (2018): http://dx.doi.org/10.1038/s41419-018-0351-1.
    10.1038/s41419-018-0351-1
  100. Cunha, Rodrigo. "Elevated Pressure Changes the Purinergic System of Microglial Cells". Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2018.00016.
    10.3389/fphar.2018.00016
  101. Cunha, Rodrigo. "Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex". Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2017.00899.
    10.3389/fphar.2017.00899
  102. Cunha, Rodrigo. "Distinct sensitivity to caffeine-induced insomnia related to age". Journal of Psychopharmacology (2018): http://dx.doi.org/10.1177/0269881117722997.
    10.1177/0269881117722997
  103. Cunha, Rodrigo. "The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo". Scientific Reports (2017): http://dx.doi.org/10.1038/s41598-017-10147-x.
    10.1038/s41598-017-10147-x
  104. Cunha, Rodrigo. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage". Cell Death & Disease (2017): http://dx.doi.org/10.1038/cddis.2017.451.
    10.1038/cddis.2017.451
  105. Cunha, Rodrigo. "Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer’s Disease". Journal of Alzheimer's Disease (2017): http://doi.org/10.3233/JAD-170356.
    10.3233/JAD-170356
  106. Cunha, Rodrigo. "Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential". Journal of Controlled Release (2017): http://dx.doi.org/10.1016/j.jconrel.2017.07.007.
    10.1016/j.jconrel.2017.07.007
  107. Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro. "Adenosine A 2A receptors are up-regulated and control the activation of human alveolar macrophages". Pulmonary Pharmacology & Therapeutics 45 (2017): 90-94. https://doi.org/10.1016/j.pupt.2017.04.009.
    10.1016/j.pupt.2017.04.009
  108. L Caetano; H Pinheiro; P Patrício; A Mateus-Pinheiro; N D Alves; B Coimbra; F I Baptista; et al. "Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety". Molecular Psychiatry 22 7 (2017): 1035-1043. https://doi.org/10.1038/mp.2016.173.
    10.1038/mp.2016.173
  109. Cunha, Rodrigo. "Brain Membrane Fractionation: An <em>Ex Vivo </em>Approach to Assess Subsynaptic Protein Localization". Journal of Visualized Experiments (2017): http://dx.doi.org/10.3791/55661.
    10.3791/55661
  110. Santos VV; Stark R; Rial D; Silva HB; Bayliss JA; Lemus MB; Davies JS; et al. "Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid beta (Aß1-40) administration in mice.". (2017): http://europepmc.org/abstract/med/28380673.
    10.1111/jne.12476
  111. Machado NJ; Simões AP; Silva HB; Ardais AP; Kaster MP; Garção P; Rodrigues DI; et al. "Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.". (2017): http://europepmc.org/abstract/med/26860412.
    10.1007/s12035-016-9774-9
  112. Gonçalves N; Simões AT; Prediger RD; Hirai H; Cunha RA; Pereira de Almeida L. "Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.". (2017): http://europepmc.org/abstract/med/28032667.
    10.1002/ana.24867
  113. Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al. "Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.". (2017): http://europepmc.org/abstract/med/27762079.
    10.1111/cns.12649
  114. Rial D; Morató X; Real JI; Gonçalves FQ; Stagljar I; Pereira FC; Fernández-Dueñas V; Cunha RA; Ciruela F. "Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.". (2017): http://europepmc.org/abstract/med/28007645.
    10.1016/j.neulet.2016.12.040
  115. Ferreira DG; Batalha VL; Vicente Miranda H; Coelho JE; Gomes R; Gonçalves FQ; Real JI; et al. "Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity.". (2017): http://europepmc.org/abstract/med/26534909.
    10.1093/cercor/bhv268
  116. Rodrigo A. Cunha. "How does adenosine control neuronal dysfunction and neurodegeneration?". Journal of Neurochemistry (2016): http://dx.doi.org/10.1111/jnc.13724.
    10.1111/jnc.13724
  117. Ana Patrícia Simões; Nuno J Machado; Nélio Gonçalves; Manuella P Kaster; Ana T Simões; Ana Nunes; Luís Pereira de Almeida; et al. "Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory". Neuropsychopharmacology 41 12 (2016): 2862-2871. https://doi.org/10.1038/npp.2016.98.
    10.1038/npp.2016.98
  118. Köfalvi A; Lemos C; Martín-Moreno AM; Pinheiro BS; García-García L; Pozo MA; Valério-Fernandes Â; et al. "Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.". (2016): http://europepmc.org/abstract/med/26976670.
    10.1016/j.neuropharm.2016.03.015
  119. Duarte FV; Amorim JA; Varela AT; Teodoro JS; Gomes AP; Cunha RA; Palmeira CM; Rolo AP. "Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.". (2016): http://europepmc.org/abstract/med/27848069.
  120. Harmatz ES; Stone L; Lim SH; Lee G; McGrath A; Gisabella B; Peng X; et al. "Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.". (2016): http://europepmc.org/abstract/med/28010876.
    10.1016/j.biopsych.2016.11.009
  121. Rodrigues L; Miranda IM; Andrade GM; Mota M; Cortes L; Rodrigues AG; Cunha RA; Gonçalves T. "Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.". (2016): http://europepmc.org/abstract/med/27590517.
    10.18632/oncotarget.11760
  122. Matheus FC; Rial D; Real JI; Lemos C; Takahashi RN; Bertoglio LJ; Cunha RA; Prediger RD. "Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.". (2016): http://europepmc.org/abstract/med/26164273.
    10.1007/s12035-015-9330-z
  123. Pinheiro BS; Lemos C; Neutzling Kaufmann F; Marques JM; da Silva-Santos CS; Carvalho E; Mackie K; et al. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.". (2016): http://europepmc.org/abstract/med/27208730.
    10.1016/j.brainresbull.2016.05.009
  124. Rodrigues RJ; Almeida T; Díaz-Hernández M; Marques JM; Franco R; Solsona C; Miras-Portugal MT; Ciruela F; Cunha RA. "Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.". (2016): http://europepmc.org/abstract/med/26801076.
    10.1016/j.neuropharm.2016.01.022
  125. Moidunny S; Matos M; Wesseling E; Banerjee S; Volsky DJ; Cunha RA; Agostinho P; Boddeke HW; Roy S. "Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.". (2016): http://europepmc.org/abstract/med/27287400.
    10.1186/s12974-016-0613-8
  126. George J; Cunha RA; Mulle C; Amédée T. "Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.". (2016): http://europepmc.org/abstract/med/27199162.
    10.1111/ejn.13191
  127. Pliássova A; Canas PM; Xavier AC; da Silva BS; Cunha RA; Agostinho P. "Age-Related Changes in the Synaptic Density of Amyloid-ß Protein Precursor and Secretases in the Human Cerebral Cortex.". (2016): http://europepmc.org/abstract/med/27104908.
    10.3233/jad-160213
  128. Ardais AP; Rocha AS; Borges MF; Fioreze GT; Sallaberry C; Mioranzza S; Nunes F; et al. "Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life.". (2016): http://europepmc.org/abstract/med/26774980.
    10.1016/j.bbr.2016.01.026
  129. João M. N. Duarte; Rodrigo A. Cunha; Rui A. Carvalho. "Adenosine A1 receptors control the metabolic recovery after hypoxia in rat hippocampal slices". Journal of Neurochemistry 136 5 (2016): 947-957. https://doi.org/10.1111%2Fjnc.13512.
    10.1111/jnc.13512
  130. Rodrigues L; Russo-Abrahão T; Cunha RA; Gonçalves T; Meyer-Fernandes JR. "Characterization of extracellular nucleotide metabolism in Candida albicans.". (2016): http://europepmc.org/abstract/med/26538575.
    10.1093/femsle/fnv212
  131. Viana da Silva S; Haberl MG; Zhang P; Bethge P; Lemos C; Gonçalves N; Gorlewicz A; et al. "Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.". (2016): http://europepmc.org/abstract/med/27312972.
    10.1038/ncomms11915
  132. Ardais, Ana Paula; Rocha, Andreia S.; Borges, Mauricio Felisberto; Fioreze, Gabriela T.; Sallaberry, Cassia; Mioranzza, Sabrina; Nunes, Fernanda; et al. "Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life". Behavioural Brain Research 303 (2016): 76-84. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372688900010&KeyUID=CCC:000372688900010.
  133. Matheus, Filipe C.; Rial, Daniel; Real, Joana I.; Lemos, Cristina; Ben, Juliana; Guaita, Gisele O.; Pita, Ines R.; et al. "Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats". Behavioural Brain Research 301 (2016): 43-54. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370108600006&KeyUID=WOS:000370108600006.
    10.1016/j.bbr.2015.12.011
  134. Rial, Daniel; Lemos, Cristina; Pinheiro, Helena; Duarte, Joana M.; Goncalves, Francisco Q.; Real, Joana I.; Prediger, Rui D.; et al. "Depression as a Glial-Based Synaptic Dysfunction". Frontiers in Cellular Neuroscience 9 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368534000001&KeyUID=WOS:000368534000001.
    10.3389/fncel.2015.00521
  135. Lemos, C.; Rial, D.; Goncalves, F. Q.; Pires, J.; Silva, H. B.; Matheus, F. C.; Da Silva, A. C.; et al. "HIGH SUCROSE CONSUMPTION INDUCES MEMORY IMPAIRMENT IN RATS ASSOCIATED WITH ELECTROPHYSIOLOGICAL MODIFICATIONS BUT NOT WITH METABOLIC CHANGES IN THE HIPPOCAMPUS". Neuroscience 315 (2016): 196-205. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368312700015&KeyUID=WOS:000368312700015.
    10.1016/j.neuroscience.2015.12.018
  136. Madeira, Maria H.; Boia, Raquel; Elvas, Filipe; Martins, Tiago; Cunha, Rodrigo A.; Ambrosio, Antonio Francisco; Santiago, Ana Raquel. "Selective A(2A) receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury". Translational Research 169 (2016): 112-128. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370392700010&KeyUID=WOS:000370392700010.
    10.1016/j.trsl.2015.11.005
  137. Li P; Rial D; Canas PM; Yoo JH; Li W; Zhou X; Wang Y; et al. "Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.". (2015): http://europepmc.org/abstract/med/25802981.
    10.1038/mp.2015.43
  138. Rodrigues, Ricardo J.; Tome, AngeloR; Cunha, Rodrigo A.. "ATP as a multi-target danger signal in the brain". Frontiers in Neuroscience 9 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353649000001&KeyUID=WOS:000353649000001.
    10.3389/fnins.2015.00148
  139. Kaster, Manuella P.; Machado, Nuno J.; Silva, Henrique B.; Nunes, Ana; Ardais, Ana Paula; Santana, Magda; Baqi, Younis; et al. "Caffeine acts through neuronal adenosine A(2A) receptors to prevent mood and memory dysfunction triggered by chronic stress". Proceedings of the National Academy of Sciences of the United States of America 112 25 (2015): 7833-7838. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356731300082&KeyUID=WOS:000356731300082.
    10.1073/pnas.1423088112
  140. Lopes, P. O.; Alfaro, T. M.; Lopes, P.; Cunha, R. A.; Robalo Cordeiro, C.. "Caffeine consumption and exacerbations of chronic obstructive pulmonary disease: Retrospective study". Revista Portuguesa De Pneumologia 21 5 (2015): 271-275. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360705800009&KeyUID=WOS:000360705800009.
    10.1016/j.rppnen.2015.05.001
  141. Matos, Marco; Shen, Hai-Ying; Augusto, Elisabete; Wang, Yumei; Wei, Catherine J.; Wang, Yu Tian; Agostinho, Paula; et al. "Deletion of Adenosine A(2A) Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia". Biological Psychiatry 78 11 (2015): 763-774. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365046200008&KeyUID=WOS:000365046200008.
    10.1016/j.biopsych.2015.02.026
  142. George, Jimmy; Goncalves, Francisco Q.; Cristovao, Goncalo; Rodrigues, Lisa; Meyer Fernandes, Jose Roberto; Goncalves, Teresa; Cunha, Rodrigo A.; Gomes, Catarina A.. "Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism". Glia 63 9 (2015): 1636-1645. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357958100011&KeyUID=WOS:000357958100011.
    10.1002/glia.22833
  143. Travassos, Maria; Santana, Isabel; Baldeiras, Ines; Tsolaki, Magda; Gkatzima, Olymbia; Genc, Sermin; Yener, Gorsev G.; et al. "Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-beta Levels in Patients with Alzheimer's Disease?". Journal of Alzheimers Disease 47 4 (2015): 1069-1078. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360931300024&KeyUID=WOS:000360931300024.
    10.3233/jad-150374
  144. Tyebji, Shiraz; Saavedra, Ana; Canas, Paula M.; Pliassova, Anna; Delgado-Garcia, Jose M.; Alberch, Jordi; Cunha, Rodrigo A.; Gruart, Agnes; Perez-Navarro, Esther. "Hyperactivation of D1 and A(2A) receptors contributes to cognitive dysfunction in Huntington's disease". Neurobiology of Disease 74 (2015): 41-57. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349655900005&KeyUID=WOS:000349655900005.
    10.1016/j.nbd.2014.11.004
  145. Pagnussat, N.; Almeida, A. S.; Marques, D. M.; Nunes, F.; Chenet, G. C.; Botton, P. H. S.; Mioranzza, S.; et al. "Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice". British Journal of Pharmacology 172 15 (2015): 3831-3845. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357952500011&KeyUID=WOS:000357952500011.
    10.1111/bph.13180
  146. Madeira, Maria H.; Elvas, Filipe; Boia, Raquel; Goncalves, Francisco Q.; Cunha, Rodrigo A.; Ambrosio, Antonio Francisco; Santiago, Ana Raquel. "Adenosine A(2A)R blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure". Journal of Neuroinflammation 12 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356056700001&KeyUID=WOS:000356056700001.
    10.1186/s12974-015-0333-5
  147. Lemos, Cristina; Pinheiro, Barbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Koefalvi, Attila. "Adenosine A(2B) receptor activation stimulates glucose uptake in the mouse forebrain". Purinergic Signalling 11 4 (2015): 561-569. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365171800013&KeyUID=WOS:000365171800013.
    10.1007/s11302-015-9474-3
  148. Li, Wei; Silva, Henrique B.; Real, Joana; Wang, Yu-Mei; Rial, Daniel; Li, Ping; Payen, Marie-Pierce; et al. "Inactivation of adenosine A(2A) receptors reverses working memory deficits at early stages of Huntington's disease models". Neurobiology of Disease 79 (2015): 70-80. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356110700007&KeyUID=WOS:000356110700007.
    10.1016/j.nbd.2015.03.030
  149. Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G.. "Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices". Nmr in Biomedicine 28 9 (2015): 1111-1116. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006.
    10.1002/nbm.3355
  150. Bitencourt, Rafael M.; Alpar, Alan; Cinquina, Valentina; Ferreira, Samira G.; Pinheiro, Barbara S.; Lemos, Cristina; Ledent, Catherine; et al. "Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents". Neurochemistry International 90 (2015): 72-84. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365366600009&KeyUID=WOS:000365366600009.
    10.1016/j.neuint.2015.07.014
  151. Agostinho, Paula; Pliassova, Anna; Oliveira, Catarina R.; Cunha, Rodrigo A.. "Localization and Trafficking of Amyloid-beta Protein Precursor and Secretases: Impact on Alzheimer's Disease". Journal of Alzheimers Disease 45 2 (2015): 329-347. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351583900002&KeyUID=WOS:000351583900002.
    10.3233/jad-142730
  152. Li, P.; Rial, D.; Canas, P. M.; Yoo, J. H.; Li, W.; Zhou, X.; Wang, Y.; et al. "Optogenetic activation of intracellular adenosine A(2A) receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory". Molecular Psychiatry 20 11 (2015): 1339-1349. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363465300009&KeyUID=WOS:000363465300009.
    10.1038/mp.2014.182
  153. Ferreira, S. G.; Goncalves, F. Q.; Marques, J. M.; Tome, A. R.; Rodrigues, R. J.; Nunes-Correia, I.; Ledent, C.; et al. "Presynaptic adenosine A(2A) receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission". British Journal of Pharmacology 172 4 (2015): 1074-1086. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348507700009&KeyUID=WOS:000348507700009.
    10.1111/bph.12970
  154. Ribeiro, Patricia O.; Antunes, Luis M.; Nunes, Catarina S.; Silva, Henrique B.; Cunha, Rodrigo A.; Tome, Angelo R.. "The Effects of Different Concentrations of the alpha(2)-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice". Anesthesia and Analgesia 120 5 (2015): 1130-1137. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353342800031&KeyUID=WOS:000353342800031.
    10.1213/ane.0000000000000636
  155. Lopes, Joao P.; Morato, Xavier; Souza, Carolina; Pinhal, Cindy; Machado, Nuno J.; Canas, Paula M.; Silva, Henrique B.; et al. "The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system". Journal of Neurochemistry 134 1 (2015): 135-146. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356368800014&KeyUID=WOS:000356368800014.
    10.1111/jnc.13109
  156. Goncalves, Francisco Q.; Pires, Johny; Pliassova, Anna; Beleza, Rui; Lemos, Cristina; Marques, Joana M.; Rodrigues, Ricardo J.; et al. "Adenosine A(2b) receptors control A(1) receptor-mediated inhibition of synaptic transmission in the mouse hippocampus". European Journal of Neuroscience 41 7 (2015): 876-886. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352540800002&KeyUID=WOS:000352540800002.
    10.1111/ejn.12851
  157. Ribeiro PO; Silva HB; Tomé AR; Cunha RA; Antunes LM. "Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia.". (2014): http://europepmc.org/abstract/med/25238524.
    10.1038/laban.571
  158. Cunha, Rodrigo. "The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis". Neuropharmacology (2014):
    10.1016/j.neuropharm.2014.01.045
  159. Carmo MR; Simões AP; Fonteles AA; Souza CM; Cunha RA; Andrade GM. "ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice.". (2014): http://europepmc.org/abstract/med/24304101.
    10.1111/ejn.12435
  160. Cristovão G; Pinto MJ; Cunha RA; Almeida RD; Gomes CA. "Activation of microglia bolsters synapse formation.". (2014): http://europepmc.org/abstract/med/24917790.
    10.3389/fncel.2014.00153
  161. Coelho JE; Alves P; Canas PM; Valadas JS; Shmidt T; Batalha VL; Ferreira DG; et al. "Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.". (2014): http://europepmc.org/abstract/med/24982640.
    10.3389/fpsyt.2014.00067
  162. Canas, P.M.; Simões, A.P.; Rodrigues, R.J.; Cunha, R.A.. "Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease". Neuropharmacology 76 PART A (2014): 51-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886592954&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2013.08.026
  163. Ribeiro, Patricia O.; Silva, Henrique B.; Tome, Angelo R.; Cunha, Rodrigo A.; Antunes, Luis M.. "Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia". Lab Animal 43 10 (2014): 343-347. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000342719300019&KeyUID=WOS:000342719300019.
  164. Zappettini, Stefania; Grilli, Massimo; Olivero, Guendalina; Chen, Jiayang; Padolecchia, Cristina; Pittaluga, Anna; Tome, Angelo R.; Cunha, Rodrigo A.; Marchi, Mario. "Nicotinic alpha 7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens". Frontiers in Cellular Neuroscience 8 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000344535000001&KeyUID=WOS:000344535000001.
    10.3389/fncel.2014.00332
  165. Salamone, Alessia; Zappettini, Stefania; Grilli, Massimo; Olivero, Guendalina; Agostinho, Paula; Tome, Angelo R.; Chen, Jiayang; et al. "Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens". Neuropharmacology 79 (2014): 488-497. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333774200050&KeyUID=WOS:000333774200050.
    10.1016/j.neuropharm.2013.12.014
  166. Santiago, Ana R.; Baptista, Filipa I.; Santos, Paulo F.; Cristovao, Goncalo; Ambrosio, Antonio F.; Cunha, Rodrigo A.; Gomes, Catarina A.. "Role of Microglia Adenosine A(2A) Receptors in Retinal and Brain Neurodegenerative Diseases". Mediators of Inflammation (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339788100001&KeyUID=WOS:000339788100001.
    10.1155/2014/465694
  167. Garcao, Pedro; Oliveira, Catarina R.; Cunha, Rodrigo A.; Agostinho, Paula. "Subsynaptic localization of nicotinic acetylcholine receptor subunits: A comparative study in the mouse and rat striatum". Neuroscience Letters 566 (2014): 106-110. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335613800022&KeyUID=WOS:000335613800022.
    10.1016/j.neulet.2014.02.018
  168. Rodrigues, Diana I.; Gutierres, Jessie; Pliassova, Anna; Oliveira, Catarina R.; Cunha, Rodrigo A.; Agostinho, Paula. "Synaptic and Sub-Synaptic Localization of Amyloid-beta Protein Precursor in the Rat Hippocampus". Journal of Alzheimers Disease 40 4 (2014): 981-992. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336262000016&KeyUID=WOS:000336262000016.
    10.3233/jad-132030
  169. Cristovao, Goncalo; Pinto, Maria J.; Cunha, Rodrigo A.; Almeida, Ramiro D.; Gomes, Catarina A.. "Activation of microglia bolsters synapse formation". Frontiers in Cellular Neuroscience 8 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336831500002&KeyUID=WOS:000336831500002.
    10.3389/fnce1.2014.00153
  170. Carmo, Marta R. S.; Simoes, Ana Patricia; Fonteles, Analu A.; Souza, Carolina M.; Cunha, Rodrigo A.; Andrade, Geanne M.. "ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice". European Journal of Neuroscience 39 4 (2014): 614-622. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000331338500009&KeyUID=WOS:000331338500009.
  171. Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garcao, Pedro; Goncalves, Francisco Q.; Silva, Henrique B.; Tome, Angelo R.; et al. "Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease". Plos One 9 12 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346907600046&KeyUID=WOS:000346907600046.
    10.1371/journal.pone.0114216
  172. Ardais, A. P.; Borges, M. F.; Rocha, A. S.; Sallaberry, C.; Cunha, R. A.; Porciuncula, L. O.. "CAFFEINE TRIGGERS BEHAVIORAL AND NEUROCHEMICAL ALTERATIONS IN ADOLESCENT RATS". Neuroscience 270 (2014): 27-39. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336624000004&KeyUID=WOS:000336624000004.
    10.1016/j.neuroscience.2014.04.003
  173. Rial, Daniel; Pandolfo, Pablo; Bitencourt, Rafael M.; Pamplona, Fabricio A.; Moreira, Karin M.; Hipolide, Debora; Dombrowski, Patricia A.; et al. "Cellular prion protein (PrPC) modulates ethanol-induced behavioral adaptive changes in mice". Behavioural Brain Research 271 (2014): 325-332. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340323000043&KeyUID=WOS:000340323000043.
    10.1016/j.bbr.2014.05.067
  174. Rial, Daniel; Pamplona, Fabricio A.; Moreira, Eduardo L. G.; Moreira, Karin M.; Hipolide, Debora; Rodrigues, Diana I.; Dombrowski, Patricia A.; et al. "Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system". European Journal of Neuroscience 40 3 (2014): 2479-2486. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340502500002&KeyUID=WOS:000340502500002.
    10.1111/ejn.12600
  175. Ribeiro, Patricia O.; Tome, Angelo R.; Silva, Henrique B.; Cunha, Rodrigo A.; Antunes, Luis M.. "Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices". Brain Research 1560 (2014): 10-17. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335874700002&KeyUID=WOS:000335874700002.
    10.1016/j.brainres.2014.03.004
  176. Matos M; Augusto E; Agostinho P; Cunha RA; Chen JF. "Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-a2 controlling glutamate uptake in astrocytes.". (2013): http://europepmc.org/abstract/med/24259572.
    10.1523/jneurosci.1828-13.2013
  177. Silva CD; Neves AF; Dias AI; Freitas HJ; Mendes SM; Pita I; Viana SD; et al. "A Single Neurotoxic Dose of Methamphetamine Induces a Long-Lasting Depressive-Like Behaviour in Mice.". (2013): http://europepmc.org/abstract/med/24072398.
    10.1007/s12640-013-9423-2
  178. Pandolfo P; Machado NJ; Köfalvi A; Takahashi RN; Cunha RA. "Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder.". (2013): http://europepmc.org/abstract/med/22561003.
    10.1016/j.euroneuro.2012.04.011
  179. Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al. "Spatial memory impairments in a prediabetic rat model". Neuroscience 250 (2013): 565-577. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2013.07.055
  180. Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A.. "Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum". British Journal of Pharmacology 169 7 (2013): 1600-1611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS.
    10.1111/bph.12234
  181. Silva, C.G.; Métin, C.; Fazeli, W.; Machado, N.J.; Darmopil, S.; Launay, P.-S.; Ghestem, A.; et al. "Adenosine receptor antagonists including caffeine alter fetal brain development in mice". Science Translational Medicine 5 197 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883887587&partnerID=MN8TOARS.
    10.1126/scitranslmed.3006258
  182. Aguiar, A.S.; Moreira, E.L.G.; Hoeller, A.A.; Oliveira, P.A.; Córdova, F.M.; Glaser, V.; Walz, R.; et al. "Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice". Neuroscience 243 (2013): 46-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877328176&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2013.03.039
  183. Augusto, E.; Matos, M.; Sévigny, J.; El-Tayeb, A.; Bynoe, M.S.; Müller, C.E.; Cunha, R.A.; Chen, J.-F.. "Ecto-5'- nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions". Journal of Neuroscience 33 28 (2013): 11390-11399. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880426005&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.5817-12.2013
  184. Gonçalves, N.; Simões, A.T.; Cunha, R.A.; De Almeida, L.P.. "Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease". Annals of Neurology 73 5 (2013): 655-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS.
    10.1002/ana.23866
  185. Wei, C.J.; Augusto, E.; Gomes, C.A.; Singer, P.; Wang, Y.; Boison, D.; Cunha, R.A.; Yee, B.K.; Chen, J.-F.. "Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain". Biological Psychiatry (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879384311&partnerID=MN8TOARS.
    10.1016/j.biopsych.2013.05.003
  186. Gomes, C.; Ferreira, R.; George, J.; Sanches, R.; Rodrigues, D.I.; Gonçalves, N.; Cunha, R.A.. "Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia". Journal of Neuroinflammation 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873021276&partnerID=MN8TOARS.
    10.1186/1742-2094-10-16
  187. Espinosa, J.; Rocha, A.; Nunes, F.; Costa, M.S.; Schein, V.; Kazlauckas, V.; Kalinine, E.; et al. "Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia". Journal of Alzheimer's Disease 34 2 (2013): 509-518. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874311332&partnerID=MN8TOARS.
    10.3233/JAD-111982
  188. Shen, Hai-Ying; Canas, Paula M.; Garcia-Sanz, Patricia; Lan, Jing-Quan; Boison, Detlev; Moratalla, Rosario; Cunha, Rodrigo A.; Chen, Jiang-Fan. "Adenosine A(2A) Receptors in Striatal Glutamatergic Terminals and GABAergic Neurons Oppositely Modulate Psychostimulant Action and DARPP-32 Phosphorylation". Plos One 8 11 (2013): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327657900015&KeyUID=WOS:000327657900015.
    10.1371/journal.pone.0080902
  189. Simões, A.P.; Duarte, J.A.; Agasse, F.; Canas, P.M.; Tomé, A.R.; Agostinho, P.; Cunha, R.A.. "Blockade of adenosine A 2A receptors prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway". Journal of Neuroinflammation 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865050131&partnerID=MN8TOARS.
    10.1186/1742-2094-9-204
  190. Matos, M.; Augusto, E.; MacHado, N.J.; Dos Santos-Rodrigues, A.; Cunha, R.A.; Agostinho, P.. "Astrocytic adenosine A 2A receptors control the amyloid-ß peptide-induced decrease of glutamate uptake". Journal of Alzheimer's Disease 31 3 (2012): 555-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865592766&partnerID=MN8TOARS.
    10.3233/JAD-2012-120469
  191. Duarte, J.M.N.; Agostinho, P.M.; Carvalho, R.A.; Cunha, R.A.. "Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of nonczno10/ltj mice". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859733227&partnerID=MN8TOARS.
    10.1371/journal.pone.0021899
  192. Matos, M.; Augusto, E.; Santos-Rodrigues, A.D.; Schwarzschild, M.A.; Chen, J.-F.; Cunha, R.A.; Agostinho, P.. "Adenosine A 2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes". GLIA 60 5 (2012): 702-716. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862776724&partnerID=MN8TOARS.
    10.1002/glia.22290
  193. Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A.. "CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus". Neurochemistry International 60 1 (2012): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.10.019
  194. Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, R.J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al. "Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing". European Journal of Neuroscience 34 1 (2011): 12-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2011.07719.x
  195. Gomes, C.V.; Kaster, M.P.; Tomé, A.R.; Agostinho, P.M.; Cunha, R.A.. "Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration". Biochimica et Biophysica Acta - Biomembranes 1808 5 (2011): 1380-1399. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953220421&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.12.001
  196. Musante, V.; Summa, M.; Cunha, R.A.; Raiteri, M.; Pittaluga, A.. "Pre-synaptic glycine GlyT1 transporter - NMDA receptor interaction: Relevance to NMDA autoreceptor activation in the presence of Mg 2+ ions". Journal of Neurochemistry 117 3 (2011): 516-527. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953877316&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07223.x
  197. Pandolfo, P.; Silveirinha, V.; Santos-Rodrigues, A.D.; Venance, L.; Ledent, C.; Takahashi, R.N.; Cunha, R.A.; Köfalvi, A.. "Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum". European Journal of Pharmacology 655 1-3 (2011): 38-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952535110&partnerID=MN8TOARS.
    10.1016/j.ejphar.2011.01.013
  198. Rebola, N.; Simões, A.P.; Canas, P.M.; Tomé, A.R.; Andrade, G.M.; Barry, C.E.; Agostinho, P.M.; Lynch, M.A.; Cunha, R.A.. "Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction". Journal of Neurochemistry 117 1 (2011): 100-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952548073&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07178.x
  199. Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P.. "Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission". Journal of Neurochemistry 116 2 (2011): 273-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2010.07101.x
  200. Agostinho, P.; Cunha, R.A.; Oliveira, C.. "Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease". Current Pharmaceutical Design 16 25 (2010): 2766-2778. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957970155&partnerID=MN8TOARS.
  201. Cunha, R.A.; Agostinho, P.M.. "Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline". Journal of Alzheimer's Disease 20 SUPPL.1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954537925&partnerID=MN8TOARS.
    10.3233/JAD-2010-1408
  202. Mendonça, A.; Cunha, R.A.. "Therapeutic opportunities for caffeine in Alzheimer's disease and other neurodegenerative disorders". Journal of Alzheimer's Disease 20 SUPPL.1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956222935&partnerID=MN8TOARS.
    10.3233/JAD-2010-01420
  203. de Mendonça, A.; Cunha, R.A.. "Putative neuroprotective effects of caffeine in clinical trials. Concluding remarks.". Journal of Alzheimer's disease : JAD 20 Suppl 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956212740&partnerID=MN8TOARS.
  204. Costenla, A.R.; Cunha, R.A.; De Mendonça, A.. "Caffeine, adenosine receptors, and synaptic plasticity". Journal of Alzheimer's Disease 20 SUPPL.1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956219897&partnerID=MN8TOARS.
    10.3233/JAD-2010-091384
  205. Cognato, G.P.; Agostinho, P.M.; Hockemeyer, J.; Müller, C.E.; Souza, D.O.; Cunha, R.A.. "Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life". Journal of Neurochemistry 112 2 (2010): 453-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-72849150168&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2009.06465.x
  206. Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F.. "Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals". Neuroscience 169 4 (2010): 1589-1600. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955414626&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2010.06.021
  207. Canas, P.M.; Porciúncula, L.O.; Cunha, G.M.A.; Silva, C.G.; Machado, N.J.; Oliveira, J.M.A.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by ß-amyloid peptides via p38 mitogen-activated protein kinase pathway". Journal of Neuroscience 29 47 (2009): 14741-14751. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449208698&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3728-09.2009
  208. Velloso, N.A.; Dalmolin, G.D.; Gomes, G.M.; Rubin, M.A.; Canas, P.M.; Cunha, R.A.; Mello, C.F.. "Spermine improves recognition memory deficit in a rodent model of Huntington's disease". Neurobiology of Learning and Memory 92 4 (2009): 574-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949090346&partnerID=MN8TOARS.
    10.1016/j.nlm.2009.07.006
  209. Quiroz, C.; Luján, R.; Uchigashima, M.; Simoes, A.P.; Lerner, T.N.; Borycz, J.; Kachroo, A.; et al. "Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway". TheScientificWorldJournal 9 (2009): 1321-1344. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949159248&partnerID=MN8TOARS.
    10.1100/tsw.2009.143
  210. Duarte, J.M.N.; Carvalho, R.A.; Cunha, R.A.; Gruetter, R.. "Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats". Journal of Neurochemistry 111 2 (2009): 368-379. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349338971&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2009.06349.x
  211. Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A.. "Modification upon aging of the density of presynaptic modulation systems in the hippocampus". Neurobiology of Aging 30 11 (2009): 1877-1884. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2008.01.003
  212. Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A.. "N-acyldopamines control striatal input terminals via novel ligand-gated cation channels". Neuropharmacology 56 3 (2009): 676-683. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2008.12.001
  213. Gomes, C.A.R.V.; Simões, P.F.; Canas, P.M.; Quiroz, C.; Sebastião, A.M.; Ferré, S.; Cunha, R.A.; Ribeiro, J.A.. "GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors". Journal of Neurochemistry 108 5 (2009): 1208-1219. http://www.scopus.com/inward/record.url?eid=2-s2.0-59449098460&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2009.05876.x
  214. Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A.. "GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx". Cell Calcium 44 6 (2008): 521-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS.
    10.1016/j.ceca.2008.03.006
  215. Cunha, R.A.. "Caffeine, adenosine receptors, memory and Alzheimer's disease | Cafeína, receptores de adenosina, memoria y enfermedad de Alzheimer". Medicina Clinica 131 20 (2008): 790-795. http://www.scopus.com/inward/record.url?eid=2-s2.0-63549108150&partnerID=MN8TOARS.
    10.1016/S0025-7753(08)75506-4
  216. Cunha, R.A.; Ferré, S.; Vaugeois, J.-M.; Chen, J.-F.. "Potential therapeutic interest of adenosine A2A receptors in Psychiatric disorders". Current Pharmaceutical Design 14 15 (2008): 1512-1524. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349125085&partnerID=MN8TOARS.
    10.2174/138161208784480090
  217. Rodrigues, R.J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A.. "Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats". Neurobiology of Aging 29 10 (2008): 1597-1601. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2007.03.025
  218. Cunha, G.M.A.; Canas, P.M.; Melo, C.S.; Hockemeyer, J.; Müller, C.E.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A2A receptor blockade prevents memory dysfunction caused by ß-amyloid peptides but not by scopolamine or MK-801". Experimental Neurology 210 2 (2008): 776-781. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136710&partnerID=MN8TOARS.
    10.1016/j.expneurol.2007.11.013
  219. Ferré, S.; Quiroz, C.; Woods, A.S.; Cunha, R.; Popoli, P.; Ciruela, F.; Lluis, C.; et al. "An update on adenosine A2A-dopamine D2 receptor interactions: Implications for the function of G protein-coupled receptors". Current Pharmaceutical Design 14 15 (2008): 1468-1474. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349126631&partnerID=MN8TOARS.
    10.2174/138161208784480108
  220. Shen, H.-Y.; Coelho, J.E.; Ohtsuka, N.; Canas, P.M.; Day, Y.-J.; Huang, Q.-Y.; Rebola, N.; et al. "A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs". Journal of Neuroscience 28 12 (2008): 2970-2975. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136068&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.5255-07.2008
  221. Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M.. "Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells". Pancreas 36 3 (2008): 279-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS.
    10.1097/MPA.0b013e31815a8473
  222. Rebola, N.; Lujan, R.; Cunha, R.A.; Mulle, C.. "Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses". Neuron 57 1 (2008): 121-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549021899&partnerID=MN8TOARS.
    10.1016/j.neuron.2007.11.023
  223. Yu, L.; Shen, H.-Y.; Coelho, J.E.; Araújo, I.M.; Huang, Q.-Y.; Day, Y.-J.; Rebola, N.; et al. "Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms". Annals of Neurology 63 3 (2008): 338-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849085227&partnerID=MN8TOARS.
    10.1002/ana.21313
  224. Cunha, R.A.. "Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity". Neurochemistry International 52 1 (2008): 65-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849073199&partnerID=MN8TOARS.
    10.1016/j.neuint.2007.06.026
  225. Schiffmann, S.N.; Fisone, G.; Moresco, R.; Cunha, R.A.; Ferré, S.. "Adenosine A2A receptors and basal ganglia physiology". Progress in Neurobiology 83 5 (2007): 277-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-36148983766&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2007.05.001
  226. Duarte, J.M.N.; Oses, J.P.; Rodrigues, R.J.; Cunha, R.A.. "Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats". Neuroscience 149 2 (2007): 382-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2007.08.005
  227. Ferré, S.; Ciruela, F.; Quiroz, C.; Luján, R.; Popoli, P.; Cunha, R.A.; Agnati, L.F.; et al. "Adenosine receptor heteromers and their integrative role in striatal function". TheScientificWorldJournal 7 SUPPL. 2 (2007): 74-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249058539&partnerID=MN8TOARS.
    10.1100/tsw.2007.211
  228. Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A.. "Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus". British Journal of Pharmacology 151 4 (2007): 551-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS.
    10.1038/sj.bjp.0707252
  229. Silva, C.G.; Porciúncula, L.O.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A.. "Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons". Neurobiology of Disease 27 2 (2007): 182-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447634291&partnerID=MN8TOARS.
    10.1016/j.nbd.2007.04.018
  230. Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al. "Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments". Journal of Neurochemistry 101 2 (2007): 355-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.04386.x
  231. Rebola, N.; Sachidhanandam, S.; Perrais, D.; Cunha, R.A.; Mulle, C.. "Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses". Journal of Neuroscience 27 15 (2007): 3987-3993. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247146060&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.5182-06.2007
  232. Duarte, J.M.N.; Cunha, R.A.; Carvalho, R.A.. "Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy". Neuroscience 144 4 (2007): 1305-1313. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846274201&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2006.11.027
  233. Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A.. "Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats". Experimental Neurology 204 1 (2007): 479-484. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS.
    10.1016/j.expneurol.2006.11.013
  234. Dall'Igna, O.P.; Fett, P.; Gomes, M.W.; Souza, D.O.; Cunha, R.A.; Lara, D.R.. "Caffeine and adenosine A2a receptor antagonists prevent ß-amyloid (25-35)-induced cognitive deficits in mice". Experimental Neurology 203 1 (2007): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751427701&partnerID=MN8TOARS.
    10.1016/j.expneurol.2006.08.008
  235. Köfalvi, A.; Oliveira, C.R.; Cunha, R.A.. "Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals". Neuroscience Letters 403 1-2 (2006): 151-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS.
    10.1016/j.neulet.2006.04.030
  236. Cunha, G.M.A.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A.. "Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress". Neuroscience 141 4 (2006): 1775-1781. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747160404&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2006.05.024
  237. Coelho, J.E.; Rebola, N.; Fragata, I.; Ribeiro, J.A.; De Mendonça, A.; Cunha, R.A.. "Hypoxia-induced desensitization and internalization of adenosine A 1 receptors in the rat hippocampus". Neuroscience 138 4 (2006): 1195-1203. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644838682&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2005.12.012
  238. Pereira, D.B.; Rebola, N.; Rodrigues, R.J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B.. "TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus". Journal of Neuroscience Research 83 5 (2006): 832-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS.
    10.1002/jnr.20784
  239. Duarte, J.M.N.; Oliveira, C.R.; Ambrósio, A.F.; Cunha, R.A.. "Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats". Neurochemistry International 48 2 (2006): 144-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244450466&partnerID=MN8TOARS.
    10.1016/j.neuint.2005.08.008
  240. Ciruela, F.; Casadó, V.; Rodrigues, R.J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al. "Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers". Journal of Neuroscience 26 7 (2006): 2080-2087. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3574-05.2006
  241. Ciruela, F.; Ferré, S.; Casadó, V.; Cortés, A.; Cunha, R.A.; Lluis, C.; Franco, R.. "Heterodimeric adenosine receptors: A device to regulate neurotransmitter release". Cellular and Molecular Life Sciences 63 21 (2006): 2427-2431. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750882222&partnerID=MN8TOARS.
    10.1007/s00018-006-6216-2
  242. Rodrigues, R.J.; Almeida, T.; De Mendonça, A.; Cunha, R.A.. "Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus". Journal of Molecular Neuroscience 30 1-2 (2006): 173-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS.
    10.1385/JMN:30:1:173
  243. Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G.. "CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action". Molecular Pharmacology 70 4 (2006): 1236-1245. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS.
    10.1124/mol.106.024661
  244. Ferré S; Borycz J; Goldberg SR; Hope BT; Morales M; Lluis C; Franco R; Ciruela F; Cunha R. "Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses.". (2005): http://europepmc.org/abstract/med/16385640.
    10.1142/S0219635205000987
  245. Rebola N; Rodrigues RJ; Oliveira CR; Cunha RA. "Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons.". (2005): http://europepmc.org/abstract/med/16011860.
    10.1016/j.neuint.2005.05.009
  246. Rodrigues RJ; Almeida T; Richardson PJ; Oliveira CR; Cunha RA. "Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.". (2005): http://europepmc.org/abstract/med/16000618.
    10.1523/JNEUROSCI.0628-05.2005
  247. Cunha RA. "Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.". (2005): http://europepmc.org/abstract/med/18404497.
    10.1007/s11302-005-0649-1
  248. Pinto-Duarte A; Coelho JE; Cunha RA; Ribeiro JA; Sebastião AM. "Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus.". (2005): http://europepmc.org/abstract/med/15836618.
    10.1111/j.1471-4159.2005.03071.x
  249. Köfalvi A; Rodrigues RJ; Ledent C; Mackie K; Vizi ES; Cunha RA; Sperlágh B. "Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.". (2005): http://europepmc.org/abstract/med/15772347.
    10.1523/JNEUROSCI.4232-04.2005
  250. Rodrigues RJ; Alfaro TM; Rebola N; Oliveira CR; Cunha RA. "Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.". (2005): http://europepmc.org/abstract/med/15659214.
    10.1111/j.1471-4159.2004.02887.x
  251. Fredholm BB; Chen JF; Cunha RA; Svenningsson P; Vaugeois JM. "Adenosine and brain function.". (2005): http://europepmc.org/abstract/med/15797469.
    10.1016/S0074-7742(05)63007-3
  252. Rebola N; Porciúncula LO; Lopes LV; Oliveira CR; Soares-da-Silva P; Cunha RA. "Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.". (2005): http://europepmc.org/abstract/med/15987272.
    10.1111/j.1528-1167.2005.01026.x
  253. Rebola, N.; Porciúncula, L.O.; Lopes, L.V.; Oliveira, C.R.; Soares-Da-Silva, P.; Cunha, R.A.. "Long-term effect of convulsive behavior on the density of adenosine A 1 and A 2A receptors in the rat cerebral cortex". Epilepsia 46 SUPPL. 5 (2005): 159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844450198&partnerID=MN8TOARS.
  254. Rebola, N.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A.. "Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat". Neuroscience 132 4 (2005): 893-903. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344362097&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2005.01.014
  255. Rebola, N.; Rodrigues, R.J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus". Neuroscience 133 1 (2005): 79-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2005.01.054
  256. Alfaro, T.M.; Vigia, E.; Oliveira, C.R.; Cunha, R.A.. "Effect of free radicals on adenosine A2A and dopamine D 2 receptors in the striatum of young adult and aged rats". Neurochemistry International 45 5 (2004): 733-738. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042601106&partnerID=MN8TOARS.
    10.1016/j.neuint.2004.02.003
  257. Cunha, R.A.; Ribeiro, J.A.; Malva, J.O.. "Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid". Neurochemistry International 44 5 (2004): 371-379. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345304227&partnerID=MN8TOARS.
    10.1016/S0197-0186(03)00167-0
  258. Halldner, L.; Lopes, L.V.; Daré, E.; Lindström, K.; Johansson, B.; Ledent, C.; Cunha, R.A.; Fredholm, B.B.. "Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: Evidence that CGS 21680 binds to A1 receptors in hippocampus". Naunyn-Schmiedeberg's Archives of Pharmacology 370 4 (2004): 270-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244262300&partnerID=MN8TOARS.
    10.1007/s00210-004-0970-1
  259. Lopes, L.V.; Halldner, L.; Rebola, N.; Johansson, B.; Ledent, C.; Chen, J.F.; Fredholm, B.B.; Cunha, R.A.. "Binding of the prototypical adenosine A 2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A 1 and A 2A receptor knockout mice". British Journal of Pharmacology 141 6 (2004): 1006-1014. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942472484&partnerID=MN8TOARS.
    10.1038/sj.bjp.0705692
  260. Almeida, T.; Rodrigues, R.J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A.. "Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices". Neuroscience 122 1 (2003): 111-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS.
    10.1016/S0306-4522(03)00523-2
  261. Malva, J.O.; Silva, A.P.; Cunha, R.A.. "Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role of kainate, adenosine and neuropeptide Y receptors". Neurochemical Research 28 10 (2003): 1501-1515. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141593557&partnerID=MN8TOARS.
    10.1023/A:1025618324593
  262. Rebola, N.; Pinheiro, P.C.; Oliveira, C.R.; Malva, J.O.; Cunha, R.A.. "Subcellular localization of adenosine A1 receptors in nerve terminals and synapses of the rat hippocampus". Brain Research 987 1 (2003): 49-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142106470&partnerID=MN8TOARS.
    10.1016/S0006-8993(03)03247-5
  263. Rebola, N.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; Oliveira, C.R.; Soares-da-Silva, P.; De Mendonça, A.; Cunha, R.A.. "Decrease of adenosine A1 receptor density and of adenosine neuromodulation the hippocampus of kindled rats". European Journal of Neuroscience 18 4 (2003): 820-828. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042819806&partnerID=MN8TOARS.
    10.1046/j.1460-9568.2003.02815.x
  264. Lopes, L.V.; Rebola, N.; Pinheiro, P.C.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A3 receptors are located in neurons of the rat hippocampus". NeuroReport 14 12 (2003): 1645-1648. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141645291&partnerID=MN8TOARS.
    10.1097/00001756-200308260-00021
  265. Fredholm, B.B.; Cunha, R.A.; Svenningsson, P.. "Pharmacology of adenosine A2A receptors and therapeutic applications.". Current topics in medicinal chemistry 3 4 (2003): 413-426. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038143146&partnerID=MN8TOARS.
  266. Rebola, N.; Sebastião, A.M.; De Mendonca, A.; Oliveira, C.R.; Ribeiro, J.A.; Cunha, R.A.. "Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats". Journal of Neurophysiology 90 2 (2003): 1295-1303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042817860&partnerID=MN8TOARS.
    10.1152/jn.00896.2002
  267. Magalhães-Cardoso, M.T.; Pereira, M.F.; Oliveira, L.; Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sá, P.. "Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings". Journal of Physiology 549 2 (2003): 399-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038511040&partnerID=MN8TOARS.
  268. Cunha, R.A.. "Heteroexchange of purines in the hippocampus: Mixing-up or messing-up ATP and adenosine". British Journal of Pharmacology 139 3 (2003): 473-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038002126&partnerID=MN8TOARS.
  269. Lopes, L.V.; Rebola, N.; Costenla, A.R.; Halldner, L.; Jacobson, M.A.; Oliveira, C.R.; Richardson, P.J.; et al. "Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors". Drug Development Research 58 4 (2003): 428-438. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038388748&partnerID=MN8TOARS.
    10.1002/ddr.10188
  270. Dall'lgna, O.P.; Porciúncula, L.O.; Souza, D.O.; Cunha, R.A.; Lara, D.R.. "Neuroprotection by caffeine and adenosine A 2A receptor blockade of ß-amyloid neurotoxicity". British Journal of Pharmacology 138 7 (2003): 1207-1209. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038415954&partnerID=MN8TOARS.
    10.1038/sj.bjp.0705185
  271. Santos, D.A.; Salgado, A.I.; Cunha, R.A.. "ATP is released from nerve terminals and from activated muscle fibres on stimulation of the rat phrenic nerve". Neuroscience Letters 338 3 (2003): 225-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037422297&partnerID=MN8TOARS.
    10.1016/S0304-3940(02)01419-2
  272. Almeida, C.G.; De Mendonça, A.; Cunha, R.A.; Ribeiro, J.A.. "Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices". Neuroscience Letters 339 2 (2003): 127-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457352&partnerID=MN8TOARS.
    10.1016/S0304-3940(02)01478-7
  273. Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O.. "Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus". Neuroscience Letters 336 2 (2003): 97-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS.
    10.1016/S0304-3940(02)01217-X
  274. Rebola, N.; Oliveira, C.R.; Cunha, R.A.. "Transducing system operated by adenosine A2A receptors to facilitate acetylcholine release in the rat hippocampus". European Journal of Pharmacology 454 1 (2002): 31-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036843638&partnerID=MN8TOARS.
    10.1016/S0014-2999(02)02475-5
  275. Cunha, R.A.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; De Mendonça, A.; Sebastião, A.M.; Ribeiro, J.A.. "Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices". Pharmacology and Toxicology 90 4 (2002): 208-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036251881&partnerID=MN8TOARS.
    10.1034/j.1600-0773.2002.900407.x
  276. Lopes, L.V.; Cunha, R.A.; Kull, B.; Fredholm, B.B.; Ribeiro, J.A.. "Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition". Neuroscience 112 2 (2002): 319-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037129938&partnerID=MN8TOARS.
    10.1016/S0306-4522(02)00080-5
  277. Villa de Brito, M.T.; Canto, A.; Duarte Correia, J.H.; Cunha, R.A.; Marques, M.C.. "Adenosine A 2A receptors in portal hypertension: Their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits". British Journal of Pharmacology 135 5 (2002): 1324-1330. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036196797&partnerID=MN8TOARS.
  278. Díaz-Hernández, M.; Fátima Pereira, M.; Pintor, J.; Cunha, R.A.; Ribeiro, J.A.; Miras-Portugal, M.T.. "Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation". Journal of Pharmacology and Experimental Therapeutics 301 2 (2002): 441-450. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036232217&partnerID=MN8TOARS.
    10.1124/jpet.301.2.441
  279. Cunha, R.A.; Dolores Constantino, M.; Fonseca, E.; Ribeiro, J.A.. "Age-dependent decrease in adenosine A 1 receptor binding sites in the rat brain: Effect of cis unsaturated free fatty acids". European Journal of Biochemistry 268 10 (2001): 2939-2947. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034830959&partnerID=MN8TOARS.
    10.1046/j.1432-1327.2001.02183.x
  280. Cunha, R.A.. "Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals". Neurochemical Research 26 8-9 (2001): 979-991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034753234&partnerID=MN8TOARS.
    10.1023/A:1012392719601
  281. Bonifácio, M.J.; Sheridan, R.D.; Parada, A.; Cunha, R.A.; Patmore, L.; Soares-Da-Silva, P.. "Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: Comparison with carbamazepine". Epilepsia 42 5 (2001): 600-608. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035013202&partnerID=MN8TOARS.
    10.1046/j.1528-1157.2001.43600.x
  282. Cunha, R.A.. "Bringing the brain into the test tube: An experiment illustrating the effect of ethanol on nerve terminal viability". Biochemistry and Molecular Biology Education 29 3 (2001): 105-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899059&partnerID=MN8TOARS.
    10.1016/S1470-8175(01)00035-2
  283. Cunha, R.A.; Almeida, T.; Ribeiro, J.A.. "Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats". Journal of Neurochemistry 76 2 (2001): 372-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035140223&partnerID=MN8TOARS.
    10.1046/j.1471-4159.2001.00095.x
  284. Ribeiro, J.A.; Cunha-Reis, D.; Lopes, L.V.; Coelho, J.E.; Costenla, A.R.; Correia-de-Sá, P.; Cunha, R.A.; De Mendonça, A.; Sebastiao, A.M.. "Adenosine receptor interactions in the hippocampus". Drug Development Research 52 1-2 (2001): 337-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035028567&partnerID=MN8TOARS.
    10.1002/ddr.1132
  285. Cunha, R.A.. "Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors". Neurochemistry International 38 2 (2001): 107-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035255227&partnerID=MN8TOARS.
    10.1016/S0197-0186(00)00034-6
  286. Cunha, R.A.; Ribeiro, J.A.. "ATP as a presynaptic modulator". Life Sciences 68 2 (2000): 119-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034554789&partnerID=MN8TOARS.
  287. Sebastião, A.M.; Cunha, R.A.; De Mendonça, A.; Ribeiro, J.A.. "Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats". British Journal of Pharmacology 131 8 (2000): 1629-1634. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034531574&partnerID=MN8TOARS.
  288. Cunha, R.A.; Almeida, T.; Ribeiro, J.A.. "Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus". Journal of Biological Chemistry 275 48 (2000): 37572-37581. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535956&partnerID=MN8TOARS.
    10.1074/jbc.M003011200
  289. Pereira, M.F.; Hernández, M.D.; Pintor, J.; Miras-Portugal, M.T.; Cunha, R.A.; Ribeiro, J.A.. "Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals". Brain Research 879 1-2 (2000): 50-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342472159&partnerID=MN8TOARS.
    10.1016/S0006-8993(00)02726-8
  290. Cunha, R.A.; Cyrne, L.; Castanho, M.; Freire, A.P.. "Meeting Report - Biochemical Education at the University Level, Lisbon, Portugal, October 30-31, 1999". Biochemistry and Molecular Biology Education 28 4 (2000): 234-237. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033744526&partnerID=MN8TOARS.
    10.1016/S1470-8175(00)00008-4
  291. Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R.. "Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells". Experimental Eye Research 70 5 (2000): 577-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS.
    10.1006/exer.1999.0815
  292. Salgado, A.I.; Cunha, R.A.; Ribeiro, J.A.. "Facilitation by P2 receptor activation of acetylcholine release from rat motor nerve terminals: Interaction with presynaptic nicotinic receptors". Brain Research 877 2 (2000): 245-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034703241&partnerID=MN8TOARS.
    10.1016/S0006-8993(00)02679-2
  293. Pereira, M.F.; Cunha, R.A.; Ribeiro, J.A.. "Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats". Neurochemistry International 36 7 (2000): 563-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034214262&partnerID=MN8TOARS.
    10.1016/S0197-0186(99)00164-3
  294. Cunha, R.A.; Ribeiro, J.A.. "Adenosine A(2A) receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation". Neuroscience Letters 289 2 (2000): 127-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033624133&partnerID=MN8TOARS.
    10.1016/S0304-3940(00)01295-7
  295. A. Cunha, R.; Malva, J.O.; Ribeiro, J.A.. "Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release". FEBS Letters 469 2-3 (2000): 159-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034629239&partnerID=MN8TOARS.
    10.1016/S0014-5793(00)01272-2
  296. Cunha, R.A.; Ribeiro, J.A.. "Purinergic modulation of [3H]GABA release from rat hippocampal nerve terminals". Neuropharmacology 39 7 (2000): 1156-1167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034064253&partnerID=MN8TOARS.
    10.1016/S0028-3908(99)00237-3
  297. Cunha, R.A.; Brendel, P.; Zimmermann, H.; Ribeiro, J.A.. "Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus". Journal of Neurochemistry 74 1 (2000): 334-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033970847&partnerID=MN8TOARS.
    10.1046/j.1471-4159.2000.0740334.x
  298. Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R.. "Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress". Neurochemistry International 36 3 (2000): 255-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS.
    10.1016/S0197-0186(99)00113-8
  299. Benes, J.; Parada, A.; Figueiredo, A.A.; Alves, P.C.; Freitas, A.P.; Learmonth, D.A.; Cunha, R.A.; Garrett, J.; Soares-Da-Silva, P.. "Anticonvulsant and sodium channel-blocking properties of novel 10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives". Journal of Medicinal Chemistry 42 14 (1999): 2582-2587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566070&partnerID=MN8TOARS.
    10.1021/jm980627g
  300. Cunha, R.A.; Malva, J.O.; Ribeiro, J.A.. "Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus". Molecular Pharmacology 56 2 (1999): 429-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032793961&partnerID=MN8TOARS.
  301. Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A(2A) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 359 4 (1999): 295-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032947295&partnerID=MN8TOARS.
    10.1007/PL00005355
  302. Cunha, R.A.; Ribeiro, J.A.. "Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes". European Journal of Neuroscience 11 6 (1999): 2171-2174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033047188&partnerID=MN8TOARS.
    10.1046/j.1460-9568.1999.00661.x
  303. Almeida, T.; Cunha, R.A.; Ribeiro, J.A.. "Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus". Brain Research 826 1 (1999): 104-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033599818&partnerID=MN8TOARS.
    10.1016/S0006-8993(99)01267-6
  304. Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A1 receptor responses". European Journal of Pharmacology 383 3 (1999): 395-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779092&partnerID=MN8TOARS.
    10.1016/S0014-2999(99)00659-7
  305. Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "Cross talk between A1 and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats". Journal of Neurophysiology 82 6 (1999): 3196-3203. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033390941&partnerID=MN8TOARS.
  306. Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A(2A) receptors in the limbic cortex, but not striatum, of aged rats". Journal of Neurochemistry 73 4 (1999): 1733-1738. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032863555&partnerID=MN8TOARS.
    10.1046/j.1471-4159.1999.731733.x
  307. Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A.. "Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases". Progress in Brain Research 120 (1999): 183-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS.
  308. Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors". Journal of Neuroscience 18 6 (1998): 1987-1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032521330&partnerID=MN8TOARS.
  309. Cunha, R.A.; Foster, T.C.; Norris, C.M.; Verkhratsky, A.; Toescu, E.C.. "On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology (multiple letters)". Trends in Neurosciences 21 7 (1998): 286-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798434&partnerID=MN8TOARS.
  310. Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "ZM241385 is an antagonist of the facilitatory responses produced by the A(2A) adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus". British Journal of Pharmacology 122 7 (1997): 1279-1284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030734490&partnerID=MN8TOARS.
  311. Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "Inhibition of [3H]¿-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes". European Journal of Pharmacology 323 2-3 (1997): 167-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030610655&partnerID=MN8TOARS.
    10.1016/S0014-2999(97)00043-5
  312. Gonçalves, M.L.; Cunha, R.A.; Ribeiro, J.A.. "Adenosine A(2A) receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes". Neuroscience Letters 238 1-2 (1997): 73-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031283080&partnerID=MN8TOARS.
    10.1016/S0304-3940(97)00803-3
  313. Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sa, P.; Sebastiao, A.M.. "Purinergic regulation of acetylcholine release". Progress in Brain Research 109 (1996): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030474316&partnerID=MN8TOARS.
  314. Cunha, R.A.; Johansson, B.; Constantino, M.D.; Sebastião, A.M.; Fredholm, B.B.. "Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 353 3 (1996): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670460&partnerID=MN8TOARS.
  315. Cunha, R.A.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices". Journal of Neurochemistry 67 5 (1996): 2180-2187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029819083&partnerID=MN8TOARS.
  316. Ribeiro, J.A.; De Mendonça, A.; Correia-de-Sá, P.; Cunha, R.A.; Sebastião, A.M.. "Purinoceptors and synaptic plasticity". Drug Development Research 39 3-4 (1996): 353-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030435849&partnerID=MN8TOARS.
  317. Cunha, R.A.; Correia-de-Sá, P.; Sebastião, A.M.; Ribeiro, J.A.. "Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides". British Journal of Pharmacology 119 2 (1996): 253-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029844019&partnerID=MN8TOARS.
  318. Cunha, R.A.; Johansson, B.; Fredholm, B.B.; Alexandre Ribeiro, J.; Sebastião, A.M.. "Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus". Neuroscience Letters 196 1-2 (1995): 41-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028984662&partnerID=MN8TOARS.
  319. Cunha, R.A.; Constantino, M.D.; Sebastiao, A.M.; Ribeiro, J.A.. "Modification of A1 and A(2a) adenosine receptor binding in aged striatum, hippocampus and cortex of the rat". NeuroReport 6 11 (1995): 1583-1588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028983106&partnerID=MN8TOARS.
  320. Malva, J.O.; Ambrósio, A.F.; Cunha, R.A.; Ribeiro, J.A.; Carvalho, A.P.; Carvalho, C.M.. "A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion". Neuroscience Letters 185 2 (1995): 83-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912732&partnerID=MN8TOARS.
    10.1016/0304-3940(94)11230-G
  321. Cunha, R.A.; Johansson, B.; van der Ploeg, I.; Sebastião, A.M.; Alexandre Ribeiro, J.; Fredholm, B.B.. "Evidence for functionally important adenosine A2a receptors in the rat hippocampus". Brain Research 649 1-2 (1994): 208-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028342730&partnerID=MN8TOARS.
  322. Cunha, R.A.; Milusheva, E.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus". Journal of Neurochemistry 63 1 (1994): 207-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028241057&partnerID=MN8TOARS.
  323. Cunha, R.A.; Ribeiro, J.A.; Sebastiao, A.M.. "Purinergic modulation of the evoked release of [3H]Acetylcholine from the hippocampus and cerebral cortex of the rat: Role of the ectonucleotidases". European Journal of Neuroscience 6 1 (1994): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028031731&partnerID=MN8TOARS.
    10.1111/j.1460-9568.1994.tb00245.x
  324. Cunha, R.A.; Sebastiao, A.M.. "Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog". Pflugers Archiv European Journal of Physiology 424 5-6 (1993): 503-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027250345&partnerID=MN8TOARS.
  325. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat". Journal of Neurochemistry 59 2 (1992): 657-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026660013&partnerID=MN8TOARS.
    10.1111/j.1471-4159.1992.tb09420.x
  326. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Relative contribution of nerve endings to the release of adenine nucleotides in the innervated frog sartorius muscle". Nucleosides and Nucleotides 10 5 (1991): 1189-1190. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026070005&partnerID=MN8TOARS.
  327. Cunha, R.A.; Sebastiao, A.M.. "Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog". European Journal of Pharmacology 197 1 (1991): 83-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025829211&partnerID=MN8TOARS.
  328. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Blockade of AMP degradation allows the quantification of adenine nucleotides released by nerve stimulation in the innervated frog sartorius muscle". European Journal of Pharmacology 183 5 (1990): 1684-1685. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025106547&partnerID=MN8TOARS.
    10.1016/0014-2999(90)91979-L
  329. Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography". Chromatographia 28 11-12 (1989): 610-612. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001249211&partnerID=MN8TOARS.
    10.1007/BF02260687
Capítulo de livro
  1. Canas, Paula M.; Cunha, Rodrigo A.. "Subsynaptic Membrane Fractionation". In Receptor and Ion Channel Detection in the Brain, 31-38. Springer US, 2021.
    Publicado • 10.1007/978-1-0716-1522-5_3
  2. Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Adenosine Receptors in Alzheimer’s Disease". In The Adenosine Receptors, 259-280. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-90808-3_11
  3. Prediger, Rui Daniel; Matheus, Filipe Carvalho; de Oliveira, Paulo Alexandre; Rial, Daniel; Moretti, Morgana; de Souza, Ana Cristina Guerra; Aguiar, Aderbal Silva; Cunha, Rodrigo A.. "Adenosine A2A Receptor-Mediated Control of Non-Motor Functions in Parkinson’s Disease". In Current Topics in Neurotoxicity, 183-205. Springer International Publishing, 2015.
    Publicado • 10.1007/978-3-319-20273-0_10
  4. Prediger, Rui Daniel; Matheus, Filipe Carvalho; de Oliveira, Paulo Alexandre; Rial, Daniel; Moretti, Morgana; de Souza, Ana Cristina Guerra; Aguiar, Aderbal Silva; Cunha, Rodrigo A.. "Adenosine A2A Receptor-Mediated Control of Non-Motor Functions in Parkinson’s Disease". In Current Topics in Neurotoxicity, 183-205. Springer International Publishing, 2015.
    Publicado • 10.1007/978-3-319-20273-0_10
  5. Gomes, Catarina; George, Jimmy; Chen, Jiang-Fan; Cunha, Rodrigo A.. "Role of Adenosine A2A Receptors in the Control of Neuroinflammation—Relevance for Parkinson’s Disease". In Current Topics in Neurotoxicity, 81-99. Springer International Publishing, 2015.
    Publicado • 10.1007/978-3-319-20273-0_5
  6. Rial, Daniel; Lara, Diogo R.; Cunha, Rodrigo A.. "The Adenosine Neuromodulation System in Schizophrenia". editado por Mori, A., 395-449. 2014.
    10.1016/b978-0-12-801022-8.00016-7
  7. Santana, Magda M.; Rosmaninho-Salgado, Joana; Kaster, Manuella; Cortez, Vera; Cunha, Rodrigo A.; Cavadas, Cláudia. "Catecholamine Release Modulation by Adenosine Through A2a Receptors in Mouse Chromaffin Cells in Culture". In Catecholamine Research in the 21st Century, 244-245. Elsevier, 2014.
    10.1016/b978-0-12-800044-1.00215-4
  8. Cunha, R. A.. "Adenosine Neuromodulation and Neuroprotection". In Handbook of Neurochemistry and Molecular Neurobiology, 255-273. Springer US, 2008.
    Publicado • 10.1007/978-0-387-30382-6_11
  9. Cunha, Rodrigo A.; Chen, Jiang-Fan; Sitkovsky, Michail V.. "Opposite Modulation of Peripheral Inflammation and Neuroinflammation by Adenosine A2A Receptors". In Interaction Between Neurons and Glia in Aging and Disease, 53-79. Springer US, 2007.
    Publicado • 10.1007/978-0-387-70830-0_3
Edição de livro
  1. Malva, João; Cunha, Rodrigo; Oliveira, Catarina R., ed. Interaction Between Neurons and Glia in Aging and Disease. Springer US. 2007.
    Publicado • 10.1007/978-0-387-70830-0

Outros

Outra produção
  1. Neuronal adenosine A2A receptors signal ergogenic effects of caffeine. 2020. Aderbal S Aguiar, Jr; Ana Elisa Speck; Paula M. Canas; Rodrigo A. Cunha. https://doi.org/10.1101/2020.04.02.021923.
    10.1101/2020.04.02.021923
Atividades

Orientação

Título / Tema
Papel desempenhado		 Curso (Tipo)
Instituição / Organização
2023/07/01 - Atual Avaliação do efeito neuroprotetor do corante Brilliant Blue G sobre camundongos submetidos ao modelo animal de Alzheimer induzido por estreptozotocina
Coorientador
Universidade Federal de Santa Catarina, Brasil
2022/01/01 - 2025/11/28 Role of adenosine A2A receptors controlling synaptic senescence in ageing and Alzheimer´s disease
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/02/01 - 2024/06/30 O papel dos recetores purinérgicos do tipo P2X7 na deposição de proteínas aberrantes e desregulação de vias autofágicas no parkinsonismo experimental
Coorientador
Faculdade de Medicina da Universidade Federal do Ceara, Brasil
2020/09 - 2023/12 Papel dos recetores de adenosina A2A astrocíticos no ontrolo da aquaporina 4 sob condições de stress crónico
Coorientador
 Programa de Doutoramento em Ciências da Saúde (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/09/01 - 2022/09/01 Crosstalk entre recetores de adenosina A2A e conexina43 na doença de Alzheimer
Coorientador
Universidade de Coimbra, Portugal
2021/05 - 2022/09 Receptores CB1 e CB2 modulam o transporte de GABA em retinas embrionárias de galinha expostas à cafeína
Coorientador
Universidade Federal Fluminense, Brasil
2016/01/01 - 2020/12/31 Pathophysiological role of adenosinergic modulation within the basolateral complex of the amygdala
Orientador
 Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas (Doutoramento)
Universidade de Coimbra, Portugal
2016/01/01 - 2019/12/31 The Role of Adenosine A2A Receptor in the Migration of Cortical Principal Neurons
Coorientador
Universidade de Coimbra, Portugal
2016/01 - 2019/01 The role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons
Coorientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/02 - 2018/10 O exercício físico reduz as discinesias induzidas por L-DOPA: investigação da neuroproteção e das modificações na metaplasticidade estriatal
Coorientador
Universidade Federal de Santa Catarina, Brasil
2015/01 - 2018/06 Caffeine, adenosine and acetylcholine and neuronal function in the cortex
Coorientador
Vrije Universiteit Amsterdam, Países Baixos
2015/01 - 2018/05 Physio-patological role of ecto-5’-nucleotidase – a new target for neuroprotection
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/03 - 2018/01 Adenosine receptors in inflammatory lung diseases
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/01 - 2017/04 Neurobiology of the Circadian Clock: Metabolism Control and Implications for Alzheimer´s disease
Coorientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014/01 - 2017/04 Role of the adenosinergic system in animal models of chronic stress and depression
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 - 2016/12 Avaliação do efeito neuroprotetor da guanosina em ratos submetidos a trauma crânio encefálico: envolvimento do sistema glutamatérgico e adenosinérgico
Coorientador
Universidade Federal de Santa Maria, Brasil
2013/07 - 2016/07 Metabolic modifications associated with memory deficits
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/06 - 2016/03 Recrutamento do receptor de adenosina A2B e ativação da via de AMPc-PI3K-ERK1/2 inibem a resposta de células dendríticas infectadas por Leishmania amazonensis
Coorientador
Universidade Federal de Ouro Preto, Brasil
2013/03 - 2016/01 Purines control neuron-glia interaction during neuroinflammation
Orientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/01 - 2016/01 Candida-host interaction: role of purines and adenosine A2A receptors
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/06 - 2015/09 Estudo do efeito neuroprotetor da berberina sobre o dano neuronal, comportamento motor e memória de ratos com degeneração nidro-estriatal por 6-OHDA
Coorientador
Faculdade de Medicina da Universidade Federal do Ceara, Brasil
2012/03 - 2015/07 Dissociando anedonia de outros sintomas da depressão na doença de Parkinson em um modelo experimental em ratos : papel do estriado dorsolateral e do córtex pré-frontal
Coorientador
Universidade Federal de Santa Catarina, Brasil
2012/01 - 2015/03 Efeito neuroprotetor do antagonismo dos receptores P2X7 no parkinsonismo experimental induzido por 6-OHDA
Coorientador
Faculdade de Medicina da Universidade Federal do Ceara, Brasil
2011/02 - 2014/12 Pathophysiology of hippocampal CA3 neurons in the APP/PS1 mouse model of Alzheimer's disease
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/01 - 2014/10 Characterization of ecto-5’-nucleotidase (CD73) in the brain – role in adenosine A2A receptor activation
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/07 - 2013/12 Interação funcional entre receptores nicotínicos e de adenosina pré-sinápticos no controlo da libertação de dopamina no estriado
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03 - 2013/10 Gene transfer approach for the study of the adenosine A2A receptors role in Machado Joseph Disease
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/01 - 2013/07 Role of adenosine A2A receptors in astrocytes - implications for glutamatergic activity
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/01 - 2013/03 Estudo da interação do sistema purinérgico, colinérgico e funções cognitivas na demência esporádica do tipo Alzheimer:os efeitos das antocianinas
Coorientador
Universidade Federal de Santa Maria, Brasil
2009/10 - 2013/02 Estratégias de neuroproteção em modelos animais da doença de Parkinson: avaliação bioquímica e comportamental
Coorientador
Universidade Federal de Santa Catarina, Brasil
2009/07 - 2012/12 Regulation of mitochondrial function in ischemia/reperfusion: looking for therapeutic strategies in fatty livers
Coorientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/07 - 2012/12 Presynaptic A2A adenosine receptors control CB1 cannabinoid receptor-mediated effects at the corticostriatal nerve terminals
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/01 - 2012/12 Adenosina na vida e na morte das células ganglionares da retina, estudo da modulação e potencial efeito protetor
Coorientador
Universidade de Coimbra, Portugal
2009/06 - 2012/11 Proteína prion celular (PrPC) altera a suscetibilidade ao etanol através da modulação do sistema dopaminérgico
Coorientador
Universidade Federal de Santa Catarina, Brasil
2009/01 - 2012/04 Purinergic control of neuroinflammation and neuroprotection afforded by the blockade of P2 receptors under excitotoxic conditions in the hippocampus
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/06 - 2011/12 Effect of purines in the developing hippocampus: consequences for the establishment of circuits related to learning and memory
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/02 - 2011/02 Estudo do sistema purinérgico glial: Modulação da MAP cinase e do transporte de adenosina em culturas de glia da retina e astrócitos cerebrais
Coorientador
Universidade Federal Fluminense, Brasil
2007/03 - 2010/08 A cafeína como estratégia de prevenção do declínio cognitivo em modelos animais
Coorientador
Universidade Federal de Santa Catarina, Brasil
2001/01 - 2010/07 Depression of synaptic transmission during hypoxia - mechanisms and relevance for neuroprotection
Coorientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2006/07 - 2009/11 Neuroprotection by adenosine receptors in aged rats – role of neuroinflammation
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2006/02 - 2009/05 Avaliação do sistema purinérgico de ratos jovens e adultos após indução de epilépsia e sua interacção com parâmetros comportamentais
Coorientador
Universidade Federal do Rio Grande do Sul, Brasil
2006/01 - 2009/02 Relation between metabolic alterations in the hippocampus and memory deficits induced by diabetes
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004/10 - 2008/09 Beneficial effects of caffeine consumption on diabetes-induced alterations in the hippocampus
Orientador
Universidade de Coimbra, Portugal
2005/01 - 2008/08 Efeito dos receptores A1 e A2A de adenosina sobre alterações comportamentais, bioquímicas e morfológicas induzidas pelo estresse crónico imprevisível em camundongos
Coorientador
Universidade Federal de Santa Catarina, Brasil
2005/01 - 2008/03 Ecto-nucleotidases e indicadores de injúria cerebral: correlações com epilépsia e convulsões
Coorientador
Universidade Fderal do Rio Grande do Sul, Brasil
2003/01 - 2008/01 Neuroprotection by adenosine A2A receptors: Functional and biochemical mechanisms
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003/01 - 2007/09 Role of ATP (P2) receptors in the control of neuronal function
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005/09 - 2006/11 Envolvimento do Sistema Purinérgico, Lactato e Glicose em Insultos do Sistema Nervoso Central
Orientador
Universidade Federal do Rio Grande do Sul Instituto de Biociências, Brasil
2002/01 - 2006/03 Interaction between purinergic and nicotinic receptors
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2000/01 - 2003/10 Adenosine receptors crosstalk in the rat hippocampus
Orientador de Luísa Maria Vaqueiro Lopes
Universidade de Lisboa Faculdade de Ciências, Portugal

Tutoria

Tópico Nome do aluno
2019/05 - 2021/05 post-doc: Spatiotemporal control of hippocampal synaptic plasticity by adenosine A2A receptors Francisco Manuel Queiroz Gonçalves
2017/02 - 2018/10 post-doc: Role of A2A receptors in the ergogenic effects of caffeine Aderbal Silva Aguiar Junior
2015/07 - 2018/07 post-doc: Hybrid ionotropic receptors: a new receptor concept Joana Medeiros Vieira Marques
2013/01 - 2018/01 post-doc: Role of adenosine receptors in the prefrontal cortex in an animal model of attention deficit and hyperactivity disorders Samira Cardoso Lopes Ferreira
2014/01 - 2017/07 post-doc: Adenosine A2A receptors controlling prefrontal cortical plasticity - impact on mood and memory Joana Isabel Estudante Batista Real
2014/01 - 2017/02 post-doc: Adenosine A2A receptors in the ventral brain circuits mediate behavioral inhibition promoting depressive-like conditions Nélio da Mota Gonçalves
2012/10 - 2017/02 post-doc: Adenosine A2A receptors in the dorsomedial striatum bolster behavioral inhibition promoting depressive-like mood disorders Paula Margarida Gomes Canas
2013/01 - 2017/01 post-doc: Tinkering with adenosine metabolism to manipulate adenosine neuromodulation and bolster neuroprotection in brain disorders João Pedro Oliveira da Silva Paulino Lopes
2012/11 - 2016/11 post-doc: Role of adenosine receptors in the pathophysiology of the amygdaloid complex: implications for fear conditioning and post-traumatic stress disorder Ana Patrícia Figueiredo Rocha Simões
2010/01 - 2016/04 post-doc: Neuromodulation by adenosine of synaptic plasticity Henrique Bernardo da Silva
2009/01 - 2015/08 post-doc: Interaction between adenosine A2A receptors and growth factors in the control of neurodegeneration and brain repair Catarina Alexandra Reis Vale Gomes
2013/02 - 2015/05 post-doc: Role of adenosine A2A receptors in the control of synaptic plasticity at striatal glutamatergic synapses in health and disease Daniel Rial
2012/07 - 2014/12 post-doc: Role of adenosine A2A receptors in different brain regions in the control of chronic stress neuropathology Carolina Melo de Sousa
2011/08 - 2013/05 post-doc: Presynaptic NMDA receptors - interaction with adenosine receptors Stefania Zappettini
2010/05 - 2013/04 post-doc: Role of ATP as danger signal and therapeutic potential of P2 receptors in brain disorders Daniela Pochmann
2009/07 - 2012/12 post-doc: Role of adenosine A2A receptors in glutamatergic neurons and in microglia in the control of synaptic plasticity and brain damage Ana Margarida Quaresma Fernandes Nunes
2008/10 - 2012/07 post-doc: Opposite control by caffeine and adenosine receptors of neuronal plasticity in the hippocampus and amygdala complex after stress Manuella Pinto Kaster
2011/03 - 2012/04 post-doc: Impacto do bloqueio genético ou farmacológico de receptores A2A para a adenosina num modelo de doença de Parkinson baseado na administração intra-nasal de uma toxina (MPTP) Rui Daniel Schroder Prediger
2007/04 - 2008/05 post-doc: Functional properties of co-expressed CB1 and adenosine A2A receptors in HEK293 cells Gabriele Ghisolfi
2003/01 - 2007/06 post-doc: Role of P2 receptors in the control of hippocampal and striatal function Attila Kofalvi
2003/07 - 2005/07 post-doc: Modificação de sistemas de modulação purinérgicos em modelos experimentais de epilepsia Lisiane de Oliveira Porciúncula
2004/01 - 2004/12 post-doc: Efeito da estimulação neurotóxica com cainato e LPS sobre o sistema modulatório da adenosina e o efeito neuroprotetor pelos receptores A2A Geanne Matos da Cunha
1998/09 - 1999/09 post-doc: Role of ATP in the control of neuromuscular transmission at the rat innervated hemidiaphragm Audrey Ivanenko Salgado
Distinções

Prémio

2016 João José Freitas Sarkis Award
Clube Brasileiro de Purinas, Brasil
2011 Award of Teaching Excellence
MIT-Portugal, Portugal
2004 Neurodegenerative Diseases’ Award
Sociedade Portuguesa de Neurociências, Portugal
2002 Pfizer Award nomination
Laboratórios Pfizer Ltda, Brasil
2002 Young Investigator Award
Biologie Servier, França
1997 Award of Pharmacology
UCB Pharma Produtos Farmacêuticos LDA, Portugal
1995 Stimulus to Investigation Award
Fundação Calouste Gulbenkian, Portugal
1994 ‘Boa Esperança’ Award nomination
Fundação para a Ciência e a Tecnologia, Portugal

Título

2019 Honorary member
Clube Brasileiro de Purinas, Brasil