| Artigo em revista |
- Sofia C. Valladão; Cátia R. Lopes; João Pedro Lopes; Madalena Piteira; Pablo Pandolfo; Alexandre Santos-Rodrigues; Paula Agostinho;
et al. "Similar adenosine neuromodulation in male and female hippocampal and prefrontocortical synapses of young and aged
mice". Neuroscience Letters (2025): https://doi.org/10.1016/j.neulet.2025.138306.
10.1016/j.neulet.2025.138306
- Tyciane de Souza Nascimento; Alfaete Vieira Oliveira; Mônica de Oliveira Bélem; Jéssica Rabelo Bezerra; Marta Regina Santos
do Carmo; Mateus Edson da Silva; Rodrigo A. Cunha; et al. "The Rotenone-Induced Sporadic Parkinsonism Model: Timeline of Motor
and Non-Motor Features". European Journal of Neuroscience (2025): https://doi.org/10.1111/ejn.16669.
10.1111/ejn.16669
- Samira G. Ferreira; Rafael M. Bitencourt; Pedro Garção; Rodrigo A. Cunha; Attila Köfalvi. "Comparing adenosine A2A receptor
modulation of cannabinoid CB1 receptor-mediated inhibition of GABA and glutamate release in rodent striatal nerve terminals".
European Journal of Neuroscience (2025): https://doi.org/10.1111/ejn.16642.
10.1111/ejn.16642
- Liliana Dias; Ana Margarida Nabais; Vladimir P. P. Borges-Martins; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Impact
of Glucocorticoid-Associated Stress-Like Conditions on Aquaporin-4 in Cultured Astrocytes and Its Modulation by Adenosine
A2A Receptors". Journal of Neurochemistry (2025): https://doi.org/10.1111/jnc.16299.
10.1111/jnc.16299
- Nuno J. Machado; Ana Paula Ardais; Ana Nunes; Eszter C. Szabó; Vasco Silveirinha; Henrique B. Silva; Manuella P. Kaster; Rodrigo
A. Cunha. "Impact of Coffee Intake on Measures of Wellbeing in Mice". Nutrients (2024): https://doi.org/10.3390/nu16172920.
10.3390/nu16172920
- Diogo M. da Fonseca; Lisa Rodrigues; José Sousa-Baptista; Félix Marcos-Tejedor; Marta Mota; Rodrigo A. Cunha; Chantal Fernandes;
Teresa Gonçalves. "Caffeine Protects Keratinocytes from Trichophyton mentagrophytes Infection and Behaves as an Antidermatophytic
Agent". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25158303.
10.3390/ijms25158303
- Rodrigo A. Cunha; Francieli Rohden; Diogo O. Souza. "Instituto de pesquisa café e saúde: Prevenção de doenças e melhora da
qualidade de vida". Research, Society and Development (2024): https://doi.org/10.33448/rsd-v13i5.45666.
10.33448/rsd-v13i5.45666
- Ana Carla L. Nunes; Marta Carmo; Andrea Behrenswerth; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha. "Adenosine A2A Receptor
Blockade Provides More Effective Benefits at the Onset Rather than after Overt Neurodegeneration in a Rat Model of Parkinson’s
Disease". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25094903.
10.3390/ijms25094903
- Zhou, Xuzhao; He, Yan; Xu, Tao; Wu, Zhaofa; Guo, Wei; Xu, Xi; Liu, Yuntao; et al. "40 Hz light flickering promotes sleep through
cortical adenosine signaling". Cell Research (2024): http://dx.doi.org/10.1038/s41422-023-00920-1.
Aceite para publicação • 10.1038/s41422-023-00920-1
- Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira,
Samira G.; et al. "The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic
plasticity". Molecular Psychiatry (2024): http://dx.doi.org/10.1038/s41380-024-02412-z.
Aceite para publicação • 10.1038/s41380-024-02412-z
- Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata;
Ana Paula Tavares; et al. "The striatum drives the ergogenic effects of caffeine". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-023-09922-5.
10.1007/s11302-023-09922-5
- Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Modification of astrocytic
Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors". Cellular and Molecular Life Sciences
(2023): https://doi.org/10.1007/s00018-023-04983-6.
10.1007/s00018-023-04983-6
- Simões, Ana P.; Portes, Marina A. M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride
L.; et al. "Adenosine A2A receptors control generalization of contextual fear in rats". Translational Psychiatry 13
1 (2023): http://dx.doi.org/10.1038/s41398-023-02613-0.
Publicado • 10.1038/s41398-023-02613-0
- Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Astrocytic A2A receptors
silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice". Glia (2023): https://doi.org/10.1002/glia.24384.
10.1002/glia.24384
- Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes.
"Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to
Model Early Alzheimer’s Disease". Biomolecules (2023): https://doi.org/10.3390/biom13081173.
10.3390/biom13081173
- Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda;
et al. "Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest". Frontiers in
Behavioral Neuroscience 17 (2023): http://dx.doi.org/10.3389/fnbeh.2023.1176382.
Publicado • 10.3389/fnbeh.2023.1176382
- Pedro Valada; Sonja Hinz; Christin Vielmuth; Cátia R. Lopes; Rodrigo A. Cunha; Christa E. Müller; João Pedro Lopes. "The impact
of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside
transporters rather than the direct activation of adenosine receptors". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-022-09899-7.
10.1007/s11302-022-09899-7
- Fernandes, Mara Yone D.; Lopes, João Pedro; Silva, Henrique B.; Andrade, Geanne M.; Cunha, Rodrigo A.; Tomé, Angelo R.. "Caffeic
acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity
in mouse hippocampal slices". Neuroscience Letters 808 (2023): 137292. http://dx.doi.org/10.1016/j.neulet.2023.137292.
Publicado • 10.1016/j.neulet.2023.137292
- Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptors
Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation".
Biomolecules (2023): https://doi.org/10.3390/biom13040715.
10.3390/biom13040715
- Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá,
Ana; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex
of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences 24 8 (2023):
6968. http://dx.doi.org/10.3390/ijms24086968.
Publicado • 10.3390/ijms24086968
- Wang, Muran; Li, Peijun; Li, Zewen; da Silva, Beatriz S.; Zheng, Wu; Xiang, Zhenghua; He, Yan; et al. "Lateral septum adenosine
A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula". Nature
Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37601-x.
Publicado • 10.1038/s41467-023-37601-x
- Gonçalves, Francisco Q.; Valada, Pedro; Matos, Marco; Cunha, Rodrigo A.; Tomé, Angelo R.. "Feedback facilitation by adenosine
A2A receptors of ATP release from mouse hippocampal nerve terminals". Purinergic Signalling (2023): http://dx.doi.org/10.1007/s11302-023-09937-y.
Aceite para publicação • 10.1007/s11302-023-09937-y
- Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel;
et al. "Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral
and Electrophysiological Modifications Caused by Chronic Stress". ACS Chemical Neuroscience 14 7 (2023): 1299-1309.
http://dx.doi.org/10.1021/acschemneuro.2c00810.
Publicado • 10.1021/acschemneuro.2c00810
- Jiang-Fan Chen; Doo-Sup Choi; Rodrigo A. Cunha. "Striatopallidal adenosine A2A receptor modulation of goal-directed behavior:
Homeostatic control with cognitive flexibility". Neuropharmacology (2023): https://doi.org/10.1016/j.neuropharm.2023.109421.
10.1016/j.neuropharm.2023.109421
- Cátia R. Lopes; Andreia Oliveira; Ingride Luzio Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva;
et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain
Areas". Biomolecules (2023): https://www.mdpi.com/2218-273X/13/1/106.
10.3390/biom13010106
- Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses,
Jean-Pierre; et al. "Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a
Rat Model of Presymptomatic Parkinson’s Disease". Molecular Neurobiology 60 3 (2022): 1659-1674. http://dx.doi.org/10.1007/s12035-022-03162-1.
Aceite para publicação • 10.1007/s12035-022-03162-1
- Dewaeles, Edmone; Carvalho, Ke´vin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan;
et al. "Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin
antitumor effects". Journal of Clinical Investigation 132 22 (2022): http://dx.doi.org/10.1172/jci152924.
Publicado • 10.1172/jci152924
- Bruno Gonçalves Pinheiro; Diandra Araújo Luz; Sabrina de Carvalho Cartágenes; Luanna de Melo Pereira Fernandes; Sarah Viana
Farias; Natália Harumi Correa Kobayashi; Enéas Andrade Fontes-Júnior; et al. "The Role of the Adenosine System on Emotional
and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine".
Pharmaceuticals (2022): https://doi.org/10.3390/ph15111323.
10.3390/ph15111323
- Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Rodrigo A.
Cunha. "CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear
Memory and Amygdala Plasticity". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232112826.
10.3390/ijms232112826
- Pedro Valada; Sofia Alçada-Morais; Rodrigo A. Cunha; João Pedro Lopes. "Thebromine Targets Adenosine Receptors to Control
Hippocampal Neuronal Function and Damage". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231810510.
10.3390/ijms231810510
- Xu, Xinli; Beleza, Rui O.; Gonçalves, Francisco Q.; Valbuena, Sergio; Alçada-Morais, Sofia; Gonçalves, Nélio; Magalhães, Joana;
et al. "Adenosine A2A receptors control synaptic remodeling in the adult brain". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18884-4.
Publicado • 10.1038/s41598-022-18884-4
- Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho. "Aß1-42 peptides blunt the
adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes".
Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04492-y.
10.1007/s00018-022-04492-y
- Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie;
et al. "Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription". Journal
of Clinical Investigation 132 12 (2022): http://dx.doi.org/10.1172/jci149371.
Publicado • 10.1172/jci149371
- Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas. "Adenosine A2A receptors
blockade attenuates dexamethasone-induced alterations in cultured astrocytes". Purinergic Signalling (2022): https://doi.org/10.1007/s11302-022-09864-4.
10.1007/s11302-022-09864-4
- Carvalho da Silva, António M.; Lemos, Cristina; Silva, Henrique B.; Ferreira, Ildete L.; Tomé, Angelo R.; Rego, A. Cristina;
Cunha, Rodrigo A.. "Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism
in a Triple Transgenic Mouse Model of Alzheimer’s Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.835885.
Publicado • 10.3389/fnagi.2022.835885
- IJzerman, Adriaan P.; Jacobson, Kenneth A.; Müller, Christa E.; Cronstein, Bruce N.; Cunha, Rodrigo A.. "International Union
of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update". Pharmacological Reviews 74 2 (2022):
340-372. http://dx.doi.org/10.1124/pharmrev.121.000445.
Publicado • 10.1124/pharmrev.121.000445
- Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha;
Francisco Ciruela; Attila Köfalvi; Sergi Ferré. "Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes
in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome". Molecules (2022): https://doi.org/10.3390/molecules27051489.
10.3390/molecules27051489
- Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula
Agostinho. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's
disease based on amyloid-ß peptide exposure". Journal of Neurochemistry (2022): https://doi.org/10.1111/jnc.15575.
10.1111/jnc.15575
- Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho. "Association Between Adenosine
A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides".
Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-021-02538-z.
10.1007/s12035-021-02538-z
- Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo,
Marta; et al. "Convergence of adenosine and GABA signaling for synapse stabilization during development". Science 374
6568 (2021): http://dx.doi.org/10.1126/science.abk2055.
10.1126/science.abk2055
- Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos,
Marco; et al. "Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal
damage and hippocampal dysfunction". Neurobiology of Disease 157 (2021): 105441. http://dx.doi.org/10.1016/j.nbd.2021.105441.
Publicado • 10.1016/j.nbd.2021.105441
- Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves;
et al. "l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory".
The FASEB Journal 35 8 (2021): https://doi.org/10.1096/fj.202100336R.
10.1096/fj.202100336R
- Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A.. "Adenosine A2A Receptors as Biomarkers of Brain
Diseases". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.702581.
10.3389/fnins.2021.702581
- Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto;
Gonçalves, Teresa; Rodrigues, Lisa. "Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps
Escape". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.678568.
10.3389/fcimb.2021.678568
- Aguiar, Aderbal S.; Speck, Ana Elisa; Canas, Paula M.; Cunha, Rodrigo A.. "Deletion of CD73 increases exercise power in mice".
Purinergic Signalling 17 3 (2021): 393-397. http://dx.doi.org/10.1007/s11302-021-09797-4.
Publicado • 10.1007/s11302-021-09797-4
- Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães,
Joana; et al. "Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation
of Neuronal Polarization and Axon Formation". Cerebral Cortex 31 12 (2021): 5652-5663. http://dx.doi.org/10.1093/cercor/bhab188.
Publicado • 10.1093/cercor/bhab188
- Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix
A. A.; Porciúncula, Lisiane O.; et al. "Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses
of mouse hippocampal slices". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-89964-0.
10.1038/s41598-021-89964-0
- Lopes, Cátia R.; Cunha, Rodrigo A.; Agostinho, Paula. "Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s
Disease". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.666710.
10.3389/fnins.2021.666710
- Lopes, Cátia R.; Lourenço, Vanessa S.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula M.. "Use of knockout mice to explore
CNS effects of adenosine". Biochemical Pharmacology 187 (2021): 114367. http://dx.doi.org/10.1016/j.bcp.2020.114367.
Publicado • 10.1016/j.bcp.2020.114367
- Figueiredo, Amanda Braga; Oliveira e Castro, Renata Alves; Nogueira-Paiva, Nívia Carolina; Moreira, Filipa; Gonçalves, Francisco
Queiroz; Soares, Rodrigo Pedro; Castro-Borges, William; et al. "Clustering of adenosine A2Breceptors with ectonucleotidases
in caveolin-rich lipid rafts underlies immunomodulation byLeishmania amazonensis". The FASEB Journal 35 5 (2021):
http://dx.doi.org/10.1096/fj.202002396rr.
Publicado • 10.1096/fj.202002396rr
- Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Ângelo R.; Agostinho, Paula; Cunha, Rodrigo
A.; Prediger, Rui D.. "Exercise decreases aberrant corticostriatal plasticity in an animal model of l-DOPA-induced
dyskinesia". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320 4 (2021): R541-R546.
http://dx.doi.org/10.1152/ajpregu.00295.2020.
Publicado • 10.1152/ajpregu.00295.2020
- Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.;
Agostinho, Paula; Cunha, Rodrigo A.. "Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation
in Rats Subject to Repeated Restraint Stress". Frontiers in Cellular Neuroscience 15 (2021): http://dx.doi.org/10.3389/fncel.2021.639322.
Publicado • 10.3389/fncel.2021.639322
- Cristiane do Socorro Ferraz Maia; Letícia Yoshitome Queiroz; Igor Gonçalves Oliveira; Carla Cristiane Soares Silva; Rodrigo
A. Cunha; Deiweson Souza-Monteiro; Maria Karolina Martins Ferreira; et al. "Binge-Like Exposure During Adolescence Induces
Detrimental Effects in Alveolar Bone that Persist in Adulthood". Alcoholism: Clinical and Experimental Research 45
1 (2021): 56-63. https://doi.org/10.1111/acer.14501.
10.1111/acer.14501
- Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas.
"Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated
by Adenosine A2A Receptor Blockade". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02275-9.
10.1007/s12035-020-02275-9
- Cunha, Rodrigo. "Control of glutamate release by complexes of adenosine and cannabinoid receptors". BMC Biology (2020):
http://dx.doi.org/10.1186/s12915-020-0739-0.
10.1186/s12915-020-0739-0
- Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas.
"Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome". Neurobiology
of Disease 146 (2020): 105137-105137. https://doi.org/10.1016/j.nbd.2020.105137.
10.1016/j.nbd.2020.105137
- Agostinho, Paula; Madeira, Daniela; Dias, Liliana; Simões, Ana Patrícia; Cunha, Rodrigo A.; Canas, Paula M.. "Purinergic signaling
orchestrating neuron-glia communication". Pharmacological Research 162 (2020): 105253. http://dx.doi.org/10.1016/j.phrs.2020.105253.
Publicado • 10.1016/j.phrs.2020.105253
- "Neuronal adenosine A2A receptors signal ergogenic effects of caffeine". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-69660-1.
10.1038/s41598-020-69660-1
- de Santana Souza, Lisiane; de Siqueira, Priscila Albuquerque; Fernandes, Arlete; Silva Martins, Robertta; Cussa Kubrusly,
Regina Célia; Paes-de-Carvalho, Roberto; Cunha, Rodrigo A.; dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo. "Role of Neuropeptide
S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder". Neuroscience
448 (2020): 140-148. http://dx.doi.org/10.1016/j.neuroscience.2020.09.030.
Publicado • 10.1016/j.neuroscience.2020.09.030
- Nehlig, Astrid; Cunha, Rodrigo. "The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific
Compound in a Complex Mixture Should Not Be Evaluated in Isolation". Nutrients 12 10 (2020): 3141. http://dx.doi.org/10.3390/nu12103141.
Publicado • 10.3390/nu12103141
- "Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats".
Biomedicine & Pharmacotherapy 130 (2020): 110608-110608. http://dx.doi.org/10.1016/j.biopha.2020.110608.
10.1016/j.biopha.2020.110608
- Matilde S. Rodrigues; Cláudia Ferreira; Cândida Dias; Anna Pliássova; Lisiane Souza; Ana Ledo; João Laranjinha; Rodrigo A.
Cunha; Attila Köfalvi. "An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl
glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease". European Journal of Neuroscience (2020):
https://doi.org/10.1111/ejn.14944.
10.1111/ejn.14944
- Mack, Josiel Mileno; de Menezes Moura, Tainara; Bobinski, Franciane; Martins, Daniel Fernandes; Cunha, Rodrigo A.; Walz, Roger;
Fernandes, Pedro Augusto; et al. "Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium
dimethyldithiocarbamate administration in mice". NeuroToxicology 80 (2020): 144-154. http://dx.doi.org/10.1016/j.neuro.2020.07.008.
10.1016/j.neuro.2020.07.008
- Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo
A.; Andrade, Geanne M.. "ATP Signaling Controlling Dyskinesia Through P2X7 Receptors". Frontiers in Molecular Neuroscience
13 (2020): http://dx.doi.org/10.3389/fnmol.2020.00111.
Publicado • 10.3389/fnmol.2020.00111
- Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara
S.; Lemos, Cristina; et al. "Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose
consumption in a rat model of Type-1 diabetes". Brain Research Bulletin 161 (2020): 106-115. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004.
Publicado • 10.1016/j.brainresbull.2020.05.004
- França, Angela Patricia; Schamne, Marissa Giovanna; de Souza, Bruna Soares; da Luz Scheffer, Débora; Bernardelli, Angelica
Karina; Corrêa, Thiago; de Souza Izídio, Geison; et al. "Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments
and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity
Disorder". Molecular Neurobiology 57 9 (2020): 3902-3919. http://dx.doi.org/10.1007/s12035-020-02002-4.
Publicado • 10.1007/s12035-020-02002-4
- Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Angelo R. Tomé; Cunha,
Rodrigo A.; Ana M. Sebastião; Boison, Detlev. "Role of Adenosine in Epilepsy and Seizures". Journal of Caffeine and Adenosine
Research 10 2 (2020): 45-60. http://dx.doi.org/10.1089/caff.2019.0022.
10.1089/caff.2019.0022
- Pliássova, Anna; Henriques, Margarida; Silva, Henrique B.; Agostinho, Paula; Cunha, Rodrigo A.; Ferreira, Samira G.. "Control
of NMDA Receptor-Mediated Currents by Adenosine A1 and A2A Receptors Within the Basolateral Amygdala".
Journal of Caffeine and Adenosine Research 10 2 (2020): 61-70. http://dx.doi.org/10.1089/caff.2019.0024.
Publicado • 10.1089/caff.2019.0024
- Cunha, Rodrigo. "The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s
disease". Purinergic Signalling (2020): http://dx.doi.org/10.1007/s11302-020-09694-2.
10.1007/s11302-020-09694-2
- Cunha, Rodrigo. "Microglia cytoarchitecture in the brain of adenosine A
2A
receptor knockout mice: Brain region and sex specificities". European Journal of Neuroscience (2020): http://dx.doi.org/10.1111/ejn.14561.
10.1111/ejn.14561
- Cunha, Rodrigo. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation
of ATP-derived extracellular adenosine". Neurobiology of Disease (2019): http://dx.doi.org/10.1016/j.nbd.2019.104570.
10.1016/j.nbd.2019.104570
- Rodrigo A Cunha. "Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration". Brain (2019): https://doi.org/10.1093/brain/awz335.
10.1093/brain/awz335
- Cunha, Rodrigo. "Purinergic signalling and brain development". Seminars in Cell & Developmental Biology (2019): http://dx.doi.org/10.1016/j.semcdb.2018.12.001.
10.1016/j.semcdb.2018.12.001
- Sara L. Reis; Henrique B. Silva; Margarida Almeida; Rodrigo A. Cunha; Ana P. Simões; Paula M. Canas. "Adenosine A 1 and A
2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus". Journal of Neurochemistry
(2019): https://doi.org/10.1111/jnc.14816.
10.1111/jnc.14816
- Cunha, Rodrigo. "Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A
2A
receptor over-activation in a rat model of Parkinson's disease". British Journal of Pharmacology (2019): http://dx.doi.org/10.1111/bph.14771.
10.1111/bph.14771
- Cunha, Rodrigo. "Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix
Calibration Curve". Molecules (2019): http://dx.doi.org/10.3390/molecules24162863.
10.3390/molecules24162863
- João P. Lopes; Anna Pliássova; Rodrigo A. Cunha. "The physiological effects of caffeine on synaptic transmission and plasticity
in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors". Biochemical Pharmacology 166 (2019):
313-321. https://doi.org/10.1016/j.bcp.2019.06.008.
10.1016/j.bcp.2019.06.008
- Cunha, Rodrigo. "Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit
and hyperactivity disorder". European Journal of Neuroscience (2019): http://dx.doi.org/10.1111/ejn.14348.
10.1111/ejn.14348
- João Pedro Lopes; Rodrigo A. Cunha. "What is the extracellular calcium concentration within brain synapses?". Journal of
Neurochemistry (2019): https://doi.org/10.1111/jnc.14696.
10.1111/jnc.14696
- Cunha, Rodrigo. "Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors".
Molecular Neurobiology (2019): http://dx.doi.org/10.1007/s12035-018-1296-1.
10.1007/s12035-018-1296-1
- Rodrigo A. Cunha. "Signaling by adenosine receptors—Homeostatic or allostatic control?". PLOS Biology 17 4 (2019):
e3000213-e3000213. https://doi.org/10.1371/journal.pbio.3000213.
10.1371/journal.pbio.3000213
- Cunha, Rodrigo. "Treadmill Exercise Attenuates l-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived
Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice". Molecular Neurobiology (2019): http://dx.doi.org/10.1007/s12035-018-1278-3.
10.1007/s12035-018-1278-3
- Xavier Morató; Francisco Q. Gonçalves; João P. Lopes; Olga Jauregui; Concepció Soler; Víctor Fernández-Dueñas; Rodrigo A.
Cunha; Francisco Ciruela. "Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal
LTD IN GPR37-deficient mice". Journal of Neurochemistry 148 6 (2019): 796-809. https://doi.org/10.1111/jnc.14653.
10.1111/jnc.14653
- Cunha, Rodrigo. "Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations
in the Hippocampus". Frontiers in Neuroscience (2019): http://dx.doi.org/10.3389/fnins.2018.01015.
10.3389/fnins.2018.01015
- Cunha, Rodrigo. "Region-specific control of microglia by adenosine A2A
receptors: uncoupling anxiety and associated cognitive deficits in female rats". Glia (2019): http://dx.doi.org/10.1002/glia.23476.
10.1002/glia.23476
- Cunha, Rodrigo. "G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in
the striatum". Neural Regeneration Research (2019): http://dx.doi.org/10.4103/1673-5374.259610.
10.4103/1673-5374.259610
- Cunha, Rodrigo. "Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision
Making". Frontiers in Molecular Neuroscience (2018): http://dx.doi.org/10.3389/fnmol.2018.00475.
10.3389/fnmol.2018.00475
- Aderbal S. Aguiar, Jr; Ana Elisa Speck; Inês M. Amaral; Paula M. Canas; Rodrigo A. Cunha. "The exercise sex gap and the impact
of the estrous cycle on exercise performance in mice". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-29050-0.
10.1038/s41598-018-29050-0
- Cunha, Rodrigo. "Promises of Caffeine in Attention-Deficit/Hyperactivity Disorder: From Animal Models to Clinical Practice".
Journal of Caffeine and Adenosine Research (2018): http://dx.doi.org/10.1089/caff.2018.0016.
10.1089/caff.2018.0016
- Cunha, Rodrigo. "Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions". eneuro
(2018): http://dx.doi.org/10.1523/eneuro.0385-18.2018.
10.1523/eneuro.0385-18.2018
- Cunha, Rodrigo. "Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation".
Human Molecular Genetics (2018): http://dx.doi.org/10.1093/hmg/ddy264.
10.1093/hmg/ddy264
- Cunha, Rodrigo. "Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats". Frontiers
in Neuroscience (2018): http://dx.doi.org/10.3389/fnins.2018.00653.
10.3389/fnins.2018.00653
- António C. Silva; Cristina Lemos; Francisco Q. Gonçalves; Anna V. Pliássova; Nuno J. Machado; Henrique B. Silva; Paula M.
Canas; et al. "Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic
mouse model of Alzheimer's disease". Neurobiology of Disease 117 (2018): 72-81. https://doi.org/10.1016/j.nbd.2018.05.024.
10.1016/j.nbd.2018.05.024
- Cunha, Rodrigo. "Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal
dysfunction in adolescent female rats". Behavioural Brain Research (2018): http://dx.doi.org/10.1016/j.bbr.2018.05.007.
10.1016/j.bbr.2018.05.007
- Cunha, Rodrigo. "Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA
receptors". Molecular Psychiatry (2018): http://dx.doi.org/10.1038/s41380-018-0110-9.
10.1038/s41380-018-0110-9
- Cunha, Rodrigo. "Adenosine A2A
receptors modulate the dopamine D2
receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex". European Journal of Neuroscience
(2018): http://dx.doi.org/10.1111/ejn.13912.
10.1111/ejn.13912
- Cunha, Rodrigo. "Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal
Cortex". Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2018.00133.
10.3389/fphar.2018.00133
- Cunha, Rodrigo. "Chronic coffee consumption and respiratory disease: A systematic review". The Clinical Respiratory Journal
(2018): http://dx.doi.org/10.1111/crj.12662.
10.1111/crj.12662
- Cunha, Rodrigo. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell
Death & Disease (2018): http://dx.doi.org/10.1038/s41419-018-0351-1.
10.1038/s41419-018-0351-1
- Cunha, Rodrigo. "Elevated Pressure Changes the Purinergic System of Microglial Cells". Frontiers in Pharmacology (2018):
http://dx.doi.org/10.3389/fphar.2018.00016.
10.3389/fphar.2018.00016
- Cunha, Rodrigo. "Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex".
Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2017.00899.
10.3389/fphar.2017.00899
- Cunha, Rodrigo. "Distinct sensitivity to caffeine-induced insomnia related to age". Journal of Psychopharmacology (2018):
http://dx.doi.org/10.1177/0269881117722997.
10.1177/0269881117722997
- Cunha, Rodrigo. "The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling
its cell surface expression and function in vivo". Scientific Reports (2017): http://dx.doi.org/10.1038/s41598-017-10147-x.
10.1038/s41598-017-10147-x
- Cunha, Rodrigo. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect
retina against transient ischemic damage". Cell Death & Disease (2017): http://dx.doi.org/10.1038/cddis.2017.451.
10.1038/cddis.2017.451
- Cunha, Rodrigo. "Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling
Alzheimer’s Disease". Journal of Alzheimer's Disease (2017): http://doi.org/10.3233/JAD-170356.
10.3233/JAD-170356
- Cunha, Rodrigo. "Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential". Journal
of Controlled Release (2017): http://dx.doi.org/10.1016/j.jconrel.2017.07.007.
10.1016/j.jconrel.2017.07.007
- Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro. "Adenosine A 2A receptors are
up-regulated and control the activation of human alveolar macrophages". Pulmonary Pharmacology & Therapeutics 45 (2017):
90-94. https://doi.org/10.1016/j.pupt.2017.04.009.
10.1016/j.pupt.2017.04.009
- L Caetano; H Pinheiro; P Patrício; A Mateus-Pinheiro; N D Alves; B Coimbra; F I Baptista; et al. "Adenosine A2A receptor regulation
of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety". Molecular Psychiatry
22 7 (2017): 1035-1043. https://doi.org/10.1038/mp.2016.173.
10.1038/mp.2016.173
- Cunha, Rodrigo. "Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization". Journal
of Visualized Experiments (2017): http://dx.doi.org/10.3791/55661.
10.3791/55661
- Santos VV; Stark R; Rial D; Silva HB; Bayliss JA; Lemus MB; Davies JS; et al. "Acyl ghrelin improves cognition, synaptic plasticity
deficits and neuroinflammation following amyloid beta (Aß1-40) administration in mice.". (2017): http://europepmc.org/abstract/med/28380673.
10.1111/jne.12476
- Machado NJ; Simões AP; Silva HB; Ardais AP; Kaster MP; Garção P; Rodrigues DI; et al. "Caffeine Reverts Memory But Not Mood
Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.".
(2017): http://europepmc.org/abstract/med/26860412.
10.1007/s12035-016-9774-9
- Gonçalves N; Simões AT; Prediger RD; Hirai H; Cunha RA; Pereira de Almeida L. "Caffeine alleviates progressive motor deficits
in a transgenic mouse model of spinocerebellar ataxia.". (2017): http://europepmc.org/abstract/med/28032667.
10.1002/ana.24867
- Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al. "Methamphetamine Induces Anhedonic-Like
Behavior and Impairs Frontal Cortical Energetics in Mice.". (2017): http://europepmc.org/abstract/med/27762079.
10.1111/cns.12649
- Rial D; Morató X; Real JI; Gonçalves FQ; Stagljar I; Pereira FC; Fernández-Dueñas V; Cunha RA; Ciruela F. "Parkinson's disease-associated
GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.". (2017): http://europepmc.org/abstract/med/28007645.
10.1016/j.neulet.2016.12.040
- Ferreira DG; Batalha VL; Vicente Miranda H; Coelho JE; Gomes R; Gonçalves FQ; Real JI; et al. "Adenosine A2A Receptors Modulate
a-Synuclein Aggregation and Toxicity.". (2017): http://europepmc.org/abstract/med/26534909.
10.1093/cercor/bhv268
- Rodrigo A. Cunha. "How does adenosine control neuronal dysfunction and neurodegeneration?". Journal of Neurochemistry
(2016): http://dx.doi.org/10.1111/jnc.13724.
10.1111/jnc.13724
- Ana Patrícia Simões; Nuno J Machado; Nélio Gonçalves; Manuella P Kaster; Ana T Simões; Ana Nunes; Luís Pereira de Almeida;
et al. "Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory". Neuropsychopharmacology
41 12 (2016): 2862-2871. https://doi.org/10.1038/npp.2016.98.
10.1038/npp.2016.98
- Köfalvi A; Lemos C; Martín-Moreno AM; Pinheiro BS; García-García L; Pozo MA; Valério-Fernandes Â; et al. "Stimulation of brain
glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.". (2016): http://europepmc.org/abstract/med/26976670.
10.1016/j.neuropharm.2016.03.015
- Duarte FV; Amorim JA; Varela AT; Teodoro JS; Gomes AP; Cunha RA; Palmeira CM; Rolo AP. "Adenosine receptors: regulatory players
in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.". (2016): http://europepmc.org/abstract/med/27848069.
- Harmatz ES; Stone L; Lim SH; Lee G; McGrath A; Gisabella B; Peng X; et al. "Central Ghrelin Resistance Permits the Overconsolidation
of Fear Memory.". (2016): http://europepmc.org/abstract/med/28010876.
10.1016/j.biopsych.2016.11.009
- Rodrigues L; Miranda IM; Andrade GM; Mota M; Cortes L; Rodrigues AG; Cunha RA; Gonçalves T. "Blunted dynamics of adenosine
A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.". (2016): http://europepmc.org/abstract/med/27590517.
10.18632/oncotarget.11760
- Matheus FC; Rial D; Real JI; Lemos C; Takahashi RN; Bertoglio LJ; Cunha RA; Prediger RD. "Temporal Dissociation of Striatum
and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.". (2016):
http://europepmc.org/abstract/med/26164273.
10.1007/s12035-015-9330-z
- Pinheiro BS; Lemos C; Neutzling Kaufmann F; Marques JM; da Silva-Santos CS; Carvalho E; Mackie K; et al. "Hierarchical glucocorticoid-endocannabinoid
interplay regulates the activation of the nucleus accumbens by insulin.". (2016): http://europepmc.org/abstract/med/27208730.
10.1016/j.brainresbull.2016.05.009
- Rodrigues RJ; Almeida T; Díaz-Hernández M; Marques JM; Franco R; Solsona C; Miras-Portugal MT; Ciruela F; Cunha RA. "Presynaptic
P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.".
(2016): http://europepmc.org/abstract/med/26801076.
10.1016/j.neuropharm.2016.01.022
- Moidunny S; Matos M; Wesseling E; Banerjee S; Volsky DJ; Cunha RA; Agostinho P; Boddeke HW; Roy S. "Oncostatin M promotes
excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.". (2016): http://europepmc.org/abstract/med/27287400.
10.1186/s12974-016-0613-8
- George J; Cunha RA; Mulle C; Amédée T. "Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity
through P2X4 and A1 receptors.". (2016): http://europepmc.org/abstract/med/27199162.
10.1111/ejn.13191
- Pliássova A; Canas PM; Xavier AC; da Silva BS; Cunha RA; Agostinho P. "Age-Related Changes in the Synaptic Density of Amyloid-ß
Protein Precursor and Secretases in the Human Cerebral Cortex.". (2016): http://europepmc.org/abstract/med/27104908.
10.3233/jad-160213
- Ardais AP; Rocha AS; Borges MF; Fioreze GT; Sallaberry C; Mioranzza S; Nunes F; et al. "Caffeine exposure during rat brain
development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life.". (2016):
http://europepmc.org/abstract/med/26774980.
10.1016/j.bbr.2016.01.026
- João M. N. Duarte; Rodrigo A. Cunha; Rui A. Carvalho. "Adenosine A1 receptors control the metabolic recovery after hypoxia
in rat hippocampal slices". Journal of Neurochemistry 136 5 (2016): 947-957. https://doi.org/10.1111%2Fjnc.13512.
10.1111/jnc.13512
- Rodrigues L; Russo-Abrahão T; Cunha RA; Gonçalves T; Meyer-Fernandes JR. "Characterization of extracellular nucleotide metabolism
in Candida albicans.". (2016): http://europepmc.org/abstract/med/26538575.
10.1093/femsle/fnv212
- Viana da Silva S; Haberl MG; Zhang P; Bethge P; Lemos C; Gonçalves N; Gorlewicz A; et al. "Early synaptic deficits in the
APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.". (2016): http://europepmc.org/abstract/med/27312972.
10.1038/ncomms11915
- Ardais, Ana Paula; Rocha, Andreia S.; Borges, Mauricio Felisberto; Fioreze, Gabriela T.; Sallaberry, Cassia; Mioranzza, Sabrina;
Nunes, Fernanda; et al. "Caffeine exposure during rat brain development causes memory impairment in a sex selective manner
that is offset by caffeine consumption throughout life". Behavioural Brain Research 303 (2016): 76-84. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372688900010&KeyUID=CCC:000372688900010.
- Matheus, Filipe C.; Rial, Daniel; Real, Joana I.; Lemos, Cristina; Ben, Juliana; Guaita, Gisele O.; Pita, Ines R.; et al.
"Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats".
Behavioural Brain Research 301 (2016): 43-54. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370108600006&KeyUID=WOS:000370108600006.
10.1016/j.bbr.2015.12.011
- Rial, Daniel; Lemos, Cristina; Pinheiro, Helena; Duarte, Joana M.; Goncalves, Francisco Q.; Real, Joana I.; Prediger, Rui
D.; et al. "Depression as a Glial-Based Synaptic Dysfunction". Frontiers in Cellular Neuroscience 9 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368534000001&KeyUID=WOS:000368534000001.
10.3389/fncel.2015.00521
- Lemos, C.; Rial, D.; Goncalves, F. Q.; Pires, J.; Silva, H. B.; Matheus, F. C.; Da Silva, A. C.; et al. "HIGH SUCROSE CONSUMPTION
INDUCES MEMORY IMPAIRMENT IN RATS ASSOCIATED WITH ELECTROPHYSIOLOGICAL MODIFICATIONS BUT NOT WITH METABOLIC CHANGES IN THE
HIPPOCAMPUS". Neuroscience 315 (2016): 196-205. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368312700015&KeyUID=WOS:000368312700015.
10.1016/j.neuroscience.2015.12.018
- Madeira, Maria H.; Boia, Raquel; Elvas, Filipe; Martins, Tiago; Cunha, Rodrigo A.; Ambrosio, Antonio Francisco; Santiago,
Ana Raquel. "Selective A(2A) receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion
cells from high intraocular pressure-induced transient ischemic injury". Translational Research 169 (2016): 112-128.
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370392700010&KeyUID=WOS:000370392700010.
10.1016/j.trsl.2015.11.005
- Li P; Rial D; Canas PM; Yoo JH; Li W; Zhou X; Wang Y; et al. "Optogenetic activation of intracellular adenosine A2A receptor
signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.". (2015): http://europepmc.org/abstract/med/25802981.
10.1038/mp.2015.43
- Rodrigues, Ricardo J.; Tome, AngeloR; Cunha, Rodrigo A.. "ATP as a multi-target danger signal in the brain". Frontiers
in Neuroscience 9 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353649000001&KeyUID=WOS:000353649000001.
10.3389/fnins.2015.00148
- Kaster, Manuella P.; Machado, Nuno J.; Silva, Henrique B.; Nunes, Ana; Ardais, Ana Paula; Santana, Magda; Baqi, Younis; et
al. "Caffeine acts through neuronal adenosine A(2A) receptors to prevent mood and memory dysfunction triggered by chronic
stress". Proceedings of the National Academy of Sciences of the United States of America 112 25 (2015): 7833-7838.
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356731300082&KeyUID=WOS:000356731300082.
10.1073/pnas.1423088112
- Lopes, P. O.; Alfaro, T. M.; Lopes, P.; Cunha, R. A.; Robalo Cordeiro, C.. "Caffeine consumption and exacerbations of chronic
obstructive pulmonary disease: Retrospective study". Revista Portuguesa De Pneumologia 21 5 (2015): 271-275. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360705800009&KeyUID=WOS:000360705800009.
10.1016/j.rppnen.2015.05.001
- Matos, Marco; Shen, Hai-Ying; Augusto, Elisabete; Wang, Yumei; Wei, Catherine J.; Wang, Yu Tian; Agostinho, Paula; et al.
"Deletion of Adenosine A(2A) Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive
Impairment: Relevance to Schizophrenia". Biological Psychiatry 78 11 (2015): 763-774. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365046200008&KeyUID=WOS:000365046200008.
10.1016/j.biopsych.2015.02.026
- George, Jimmy; Goncalves, Francisco Q.; Cristovao, Goncalo; Rodrigues, Lisa; Meyer Fernandes, Jose Roberto; Goncalves, Teresa;
Cunha, Rodrigo A.; Gomes, Catarina A.. "Different danger signals differently impact on microglial proliferation through alterations
of ATP release and extracellular metabolism". Glia 63 9 (2015): 1636-1645. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357958100011&KeyUID=WOS:000357958100011.
10.1002/glia.22833
- Travassos, Maria; Santana, Isabel; Baldeiras, Ines; Tsolaki, Magda; Gkatzima, Olymbia; Genc, Sermin; Yener, Gorsev G.; et
al. "Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-beta Levels in Patients with Alzheimer's Disease?". Journal
of Alzheimers Disease 47 4 (2015): 1069-1078. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360931300024&KeyUID=WOS:000360931300024.
10.3233/jad-150374
- Tyebji, Shiraz; Saavedra, Ana; Canas, Paula M.; Pliassova, Anna; Delgado-Garcia, Jose M.; Alberch, Jordi; Cunha, Rodrigo A.;
Gruart, Agnes; Perez-Navarro, Esther. "Hyperactivation of D1 and A(2A) receptors contributes to cognitive dysfunction in Huntington's
disease". Neurobiology of Disease 74 (2015): 41-57. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349655900005&KeyUID=WOS:000349655900005.
10.1016/j.nbd.2014.11.004
- Pagnussat, N.; Almeida, A. S.; Marques, D. M.; Nunes, F.; Chenet, G. C.; Botton, P. H. S.; Mioranzza, S.; et al. "Adenosine
A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice". British Journal of Pharmacology
172 15 (2015): 3831-3845. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357952500011&KeyUID=WOS:000357952500011.
10.1111/bph.13180
- Madeira, Maria H.; Elvas, Filipe; Boia, Raquel; Goncalves, Francisco Q.; Cunha, Rodrigo A.; Ambrosio, Antonio Francisco; Santiago,
Ana Raquel. "Adenosine A(2A)R blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated
pressure". Journal of Neuroinflammation 12 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356056700001&KeyUID=WOS:000356056700001.
10.1186/s12974-015-0333-5
- Lemos, Cristina; Pinheiro, Barbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial,
Daniel; Koefalvi, Attila. "Adenosine A(2B) receptor activation stimulates glucose uptake in the mouse forebrain". Purinergic
Signalling 11 4 (2015): 561-569. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365171800013&KeyUID=WOS:000365171800013.
10.1007/s11302-015-9474-3
- Li, Wei; Silva, Henrique B.; Real, Joana; Wang, Yu-Mei; Rial, Daniel; Li, Ping; Payen, Marie-Pierce; et al. "Inactivation
of adenosine A(2A) receptors reverses working memory deficits at early stages of Huntington's disease models". Neurobiology
of Disease 79 (2015): 70-80. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356110700007&KeyUID=WOS:000356110700007.
10.1016/j.nbd.2015.03.030
- Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G.. "Ketone bodies effectively compete
with glucose for neuronal acetyl-CoA generation in rat hippocampal slices". Nmr in Biomedicine 28 9 (2015): 1111-1116.
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006.
10.1002/nbm.3355
- Bitencourt, Rafael M.; Alpar, Alan; Cinquina, Valentina; Ferreira, Samira G.; Pinheiro, Barbara S.; Lemos, Cristina; Ledent,
Catherine; et al. "Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic
terminals in the frontal cortex of laboratory rodents". Neurochemistry International 90 (2015): 72-84. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365366600009&KeyUID=WOS:000365366600009.
10.1016/j.neuint.2015.07.014
- Agostinho, Paula; Pliassova, Anna; Oliveira, Catarina R.; Cunha, Rodrigo A.. "Localization and Trafficking of Amyloid-beta
Protein Precursor and Secretases: Impact on Alzheimer's Disease". Journal of Alzheimers Disease 45 2 (2015): 329-347.
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351583900002&KeyUID=WOS:000351583900002.
10.3233/jad-142730
- Li, P.; Rial, D.; Canas, P. M.; Yoo, J. H.; Li, W.; Zhou, X.; Wang, Y.; et al. "Optogenetic activation of intracellular adenosine
A(2A) receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory". Molecular
Psychiatry 20 11 (2015): 1339-1349. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363465300009&KeyUID=WOS:000363465300009.
10.1038/mp.2014.182
- Ferreira, S. G.; Goncalves, F. Q.; Marques, J. M.; Tome, A. R.; Rodrigues, R. J.; Nunes-Correia, I.; Ledent, C.; et al. "Presynaptic
adenosine A(2A) receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission".
British Journal of Pharmacology 172 4 (2015): 1074-1086. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348507700009&KeyUID=WOS:000348507700009.
10.1111/bph.12970
- Ribeiro, Patricia O.; Antunes, Luis M.; Nunes, Catarina S.; Silva, Henrique B.; Cunha, Rodrigo A.; Tome, Angelo R.. "The Effects
of Different Concentrations of the alpha(2)-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and
Synaptic Plasticity in Hippocampal Slices of Adult Mice". Anesthesia and Analgesia 120 5 (2015): 1130-1137. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353342800031&KeyUID=WOS:000353342800031.
10.1213/ane.0000000000000636
- Lopes, Joao P.; Morato, Xavier; Souza, Carolina; Pinhal, Cindy; Machado, Nuno J.; Canas, Paula M.; Silva, Henrique B.; et
al. "The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic
system". Journal of Neurochemistry 134 1 (2015): 135-146. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356368800014&KeyUID=WOS:000356368800014.
10.1111/jnc.13109
- Goncalves, Francisco Q.; Pires, Johny; Pliassova, Anna; Beleza, Rui; Lemos, Cristina; Marques, Joana M.; Rodrigues, Ricardo
J.; et al. "Adenosine A(2b) receptors control A(1) receptor-mediated inhibition of synaptic transmission in the mouse hippocampus".
European Journal of Neuroscience 41 7 (2015): 876-886. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352540800002&KeyUID=WOS:000352540800002.
10.1111/ejn.12851
- Ribeiro PO; Silva HB; Tomé AR; Cunha RA; Antunes LM. "Hippocampal long-term potentiation in adult mice after recovery from
ketamine anesthesia.". (2014): http://europepmc.org/abstract/med/25238524.
10.1038/laban.571
- Cunha, Rodrigo. "The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism
through a combined control of synaptotoxicity, neurotoxicity and gliosis". Neuropharmacology (2014):
10.1016/j.neuropharm.2014.01.045
- Carmo MR; Simões AP; Fonteles AA; Souza CM; Cunha RA; Andrade GM. "ATP P2Y1 receptors control cognitive deficits and neurotoxicity
but not glial modifications induced by brain ischemia in mice.". (2014): http://europepmc.org/abstract/med/24304101.
10.1111/ejn.12435
- Cristovão G; Pinto MJ; Cunha RA; Almeida RD; Gomes CA. "Activation of microglia bolsters synapse formation.". (2014): http://europepmc.org/abstract/med/24917790.
10.3389/fncel.2014.00153
- Coelho JE; Alves P; Canas PM; Valadas JS; Shmidt T; Batalha VL; Ferreira DG; et al. "Overexpression of Adenosine A2A Receptors
in Rats: Effects on Depression, Locomotion, and Anxiety.". (2014): http://europepmc.org/abstract/med/24982640.
10.3389/fpsyt.2014.00067
- Canas, P.M.; Simões, A.P.; Rodrigues, R.J.; Cunha, R.A.. "Predominant loss of glutamatergic terminal markers in a ß-amyloid
peptide model of Alzheimer's disease". Neuropharmacology 76 PART A (2014): 51-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886592954&partnerID=MN8TOARS.
10.1016/j.neuropharm.2013.08.026
- Ribeiro, Patricia O.; Silva, Henrique B.; Tome, Angelo R.; Cunha, Rodrigo A.; Antunes, Luis M.. "Hippocampal long-term potentiation
in adult mice after recovery from ketamine anesthesia". Lab Animal 43 10 (2014): 343-347. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000342719300019&KeyUID=WOS:000342719300019.
- Zappettini, Stefania; Grilli, Massimo; Olivero, Guendalina; Chen, Jiayang; Padolecchia, Cristina; Pittaluga, Anna; Tome, Angelo
R.; Cunha, Rodrigo A.; Marchi, Mario. "Nicotinic alpha 7 receptor activation selectively potentiates the function of NMDA
receptors in glutamatergic terminals of the nucleus accumbens". Frontiers in Cellular Neuroscience 8 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000344535000001&KeyUID=WOS:000344535000001.
10.3389/fncel.2014.00332
- Salamone, Alessia; Zappettini, Stefania; Grilli, Massimo; Olivero, Guendalina; Agostinho, Paula; Tome, Angelo R.; Chen, Jiayang;
et al. "Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus
accumbens". Neuropharmacology 79 (2014): 488-497. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333774200050&KeyUID=WOS:000333774200050.
10.1016/j.neuropharm.2013.12.014
- Santiago, Ana R.; Baptista, Filipa I.; Santos, Paulo F.; Cristovao, Goncalo; Ambrosio, Antonio F.; Cunha, Rodrigo A.; Gomes,
Catarina A.. "Role of Microglia Adenosine A(2A) Receptors in Retinal and Brain Neurodegenerative Diseases". Mediators of
Inflammation (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339788100001&KeyUID=WOS:000339788100001.
10.1155/2014/465694
- Garcao, Pedro; Oliveira, Catarina R.; Cunha, Rodrigo A.; Agostinho, Paula. "Subsynaptic localization of nicotinic acetylcholine
receptor subunits: A comparative study in the mouse and rat striatum". Neuroscience Letters 566 (2014): 106-110. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335613800022&KeyUID=WOS:000335613800022.
10.1016/j.neulet.2014.02.018
- Rodrigues, Diana I.; Gutierres, Jessie; Pliassova, Anna; Oliveira, Catarina R.; Cunha, Rodrigo A.; Agostinho, Paula. "Synaptic
and Sub-Synaptic Localization of Amyloid-beta Protein Precursor in the Rat Hippocampus". Journal of Alzheimers Disease
40 4 (2014): 981-992. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336262000016&KeyUID=WOS:000336262000016.
10.3233/jad-132030
- Cristovao, Goncalo; Pinto, Maria J.; Cunha, Rodrigo A.; Almeida, Ramiro D.; Gomes, Catarina A.. "Activation of microglia bolsters
synapse formation". Frontiers in Cellular Neuroscience 8 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336831500002&KeyUID=WOS:000336831500002.
10.3389/fnce1.2014.00153
- Carmo, Marta R. S.; Simoes, Ana Patricia; Fonteles, Analu A.; Souza, Carolina M.; Cunha, Rodrigo A.; Andrade, Geanne M.. "ATP
P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice".
European Journal of Neuroscience 39 4 (2014): 614-622. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000331338500009&KeyUID=WOS:000331338500009.
- Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garcao, Pedro; Goncalves, Francisco Q.; Silva, Henrique B.; Tome, Angelo
R.; et al. "Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease".
Plos One 9 12 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346907600046&KeyUID=WOS:000346907600046.
10.1371/journal.pone.0114216
- Ardais, A. P.; Borges, M. F.; Rocha, A. S.; Sallaberry, C.; Cunha, R. A.; Porciuncula, L. O.. "CAFFEINE TRIGGERS BEHAVIORAL
AND NEUROCHEMICAL ALTERATIONS IN ADOLESCENT RATS". Neuroscience 270 (2014): 27-39. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336624000004&KeyUID=WOS:000336624000004.
10.1016/j.neuroscience.2014.04.003
- Rial, Daniel; Pandolfo, Pablo; Bitencourt, Rafael M.; Pamplona, Fabricio A.; Moreira, Karin M.; Hipolide, Debora; Dombrowski,
Patricia A.; et al. "Cellular prion protein (PrPC) modulates ethanol-induced behavioral adaptive changes in mice". Behavioural
Brain Research 271 (2014): 325-332. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340323000043&KeyUID=WOS:000340323000043.
10.1016/j.bbr.2014.05.067
- Rial, Daniel; Pamplona, Fabricio A.; Moreira, Eduardo L. G.; Moreira, Karin M.; Hipolide, Debora; Rodrigues, Diana I.; Dombrowski,
Patricia A.; et al. "Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system". European
Journal of Neuroscience 40 3 (2014): 2479-2486. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340502500002&KeyUID=WOS:000340502500002.
10.1111/ejn.12600
- Ribeiro, Patricia O.; Tome, Angelo R.; Silva, Henrique B.; Cunha, Rodrigo A.; Antunes, Luis M.. "Clinically relevant concentrations
of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse
facilitation in mouse hippocampal slices". Brain Research 1560 (2014): 10-17. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335874700002&KeyUID=WOS:000335874700002.
10.1016/j.brainres.2014.03.004
- Matos M; Augusto E; Agostinho P; Cunha RA; Chen JF. "Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-a2
controlling glutamate uptake in astrocytes.". (2013): http://europepmc.org/abstract/med/24259572.
10.1523/jneurosci.1828-13.2013
- Silva CD; Neves AF; Dias AI; Freitas HJ; Mendes SM; Pita I; Viana SD; et al. "A Single Neurotoxic Dose of Methamphetamine
Induces a Long-Lasting Depressive-Like Behaviour in Mice.". (2013): http://europepmc.org/abstract/med/24072398.
10.1007/s12640-013-9423-2
- Pandolfo P; Machado NJ; Köfalvi A; Takahashi RN; Cunha RA. "Caffeine regulates frontocorticostriatal dopamine transporter
density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder.". (2013):
http://europepmc.org/abstract/med/22561003.
10.1016/j.euroneuro.2012.04.011
- Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al. "Spatial memory impairments
in a prediabetic rat model". Neuroscience 250 (2013): 565-577. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS.
10.1016/j.neuroscience.2013.07.055
- Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A..
"Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine
release in the rat striatum". British Journal of Pharmacology 169 7 (2013): 1600-1611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS.
10.1111/bph.12234
- Silva, C.G.; Métin, C.; Fazeli, W.; Machado, N.J.; Darmopil, S.; Launay, P.-S.; Ghestem, A.; et al. "Adenosine receptor antagonists
including caffeine alter fetal brain development in mice". Science Translational Medicine 5 197 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883887587&partnerID=MN8TOARS.
10.1126/scitranslmed.3006258
- Aguiar, A.S.; Moreira, E.L.G.; Hoeller, A.A.; Oliveira, P.A.; Córdova, F.M.; Glaser, V.; Walz, R.; et al. "Exercise attenuates
levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice". Neuroscience 243 (2013): 46-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877328176&partnerID=MN8TOARS.
10.1016/j.neuroscience.2013.03.039
- Augusto, E.; Matos, M.; Sévigny, J.; El-Tayeb, A.; Bynoe, M.S.; Müller, C.E.; Cunha, R.A.; Chen, J.-F.. "Ecto-5'- nucleotidase
(CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions". Journal of Neuroscience
33 28 (2013): 11390-11399. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880426005&partnerID=MN8TOARS.
10.1523/JNEUROSCI.5817-12.2013
- Gonçalves, N.; Simões, A.T.; Cunha, R.A.; De Almeida, L.P.. "Caffeine and adenosine A2A receptor inactivation decrease striatal
neuropathology in a lentiviral-based model of Machado-Joseph disease". Annals of Neurology 73 5 (2013): 655-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS.
10.1002/ana.23866
- Wei, C.J.; Augusto, E.; Gomes, C.A.; Singer, P.; Wang, Y.; Boison, D.; Cunha, R.A.; Yee, B.K.; Chen, J.-F.. "Regulation of
Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain". Biological Psychiatry (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879384311&partnerID=MN8TOARS.
10.1016/j.biopsych.2013.05.003
- Gomes, C.; Ferreira, R.; George, J.; Sanches, R.; Rodrigues, D.I.; Gonçalves, N.; Cunha, R.A.. "Activation of microglial cells
triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent
manner: A2A receptor blockade prevents BDNF release and proliferation of microglia". Journal of Neuroinflammation 10
(2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873021276&partnerID=MN8TOARS.
10.1186/1742-2094-10-16
- Espinosa, J.; Rocha, A.; Nunes, F.; Costa, M.S.; Schein, V.; Kazlauckas, V.; Kalinine, E.; et al. "Caffeine consumption prevents
memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic
dementia". Journal of Alzheimer's Disease 34 2 (2013): 509-518. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874311332&partnerID=MN8TOARS.
10.3233/JAD-111982
- Shen, Hai-Ying; Canas, Paula M.; Garcia-Sanz, Patricia; Lan, Jing-Quan; Boison, Detlev; Moratalla, Rosario; Cunha, Rodrigo
A.; Chen, Jiang-Fan. "Adenosine A(2A) Receptors in Striatal Glutamatergic Terminals and GABAergic Neurons Oppositely Modulate
Psychostimulant Action and DARPP-32 Phosphorylation". Plos One 8 11 (2013): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327657900015&KeyUID=WOS:000327657900015.
10.1371/journal.pone.0080902
- Simões, A.P.; Duarte, J.A.; Agasse, F.; Canas, P.M.; Tomé, A.R.; Agostinho, P.; Cunha, R.A.. "Blockade of adenosine A 2A receptors
prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway".
Journal of Neuroinflammation 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865050131&partnerID=MN8TOARS.
10.1186/1742-2094-9-204
- Matos, M.; Augusto, E.; MacHado, N.J.; Dos Santos-Rodrigues, A.; Cunha, R.A.; Agostinho, P.. "Astrocytic adenosine A 2A receptors
control the amyloid-ß peptide-induced decrease of glutamate uptake". Journal of Alzheimer's Disease 31 3 (2012): 555-567.
http://www.scopus.com/inward/record.url?eid=2-s2.0-84865592766&partnerID=MN8TOARS.
10.3233/JAD-2012-120469
- Duarte, J.M.N.; Agostinho, P.M.; Carvalho, R.A.; Cunha, R.A.. "Caffeine consumption prevents diabetes-induced memory impairment
and synaptotoxicity in the hippocampus of nonczno10/ltj mice". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859733227&partnerID=MN8TOARS.
10.1371/journal.pone.0021899
- Matos, M.; Augusto, E.; Santos-Rodrigues, A.D.; Schwarzschild, M.A.; Chen, J.-F.; Cunha, R.A.; Agostinho, P.. "Adenosine A
2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes". GLIA 60 5 (2012): 702-716. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862776724&partnerID=MN8TOARS.
10.1002/glia.22290
- Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A.. "CB 1 receptor activation inhibits neuronal and
astrocytic intermediary metabolism in the rat hippocampus". Neurochemistry International 60 1 (2012): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS.
10.1016/j.neuint.2011.10.019
- Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, R.J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al. "Enhanced
role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing". European Journal of Neuroscience
34 1 (2011): 12-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS.
10.1111/j.1460-9568.2011.07719.x
- Gomes, C.V.; Kaster, M.P.; Tomé, A.R.; Agostinho, P.M.; Cunha, R.A.. "Adenosine receptors and brain diseases: Neuroprotection
and neurodegeneration". Biochimica et Biophysica Acta - Biomembranes 1808 5 (2011): 1380-1399. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953220421&partnerID=MN8TOARS.
10.1016/j.bbamem.2010.12.001
- Musante, V.; Summa, M.; Cunha, R.A.; Raiteri, M.; Pittaluga, A.. "Pre-synaptic glycine GlyT1 transporter - NMDA receptor interaction:
Relevance to NMDA autoreceptor activation in the presence of Mg 2+ ions". Journal of Neurochemistry 117 3 (2011): 516-527.
http://www.scopus.com/inward/record.url?eid=2-s2.0-79953877316&partnerID=MN8TOARS.
10.1111/j.1471-4159.2011.07223.x
- Pandolfo, P.; Silveirinha, V.; Santos-Rodrigues, A.D.; Venance, L.; Ledent, C.; Takahashi, R.N.; Cunha, R.A.; Köfalvi, A..
"Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum". European Journal of
Pharmacology 655 1-3 (2011): 38-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952535110&partnerID=MN8TOARS.
10.1016/j.ejphar.2011.01.013
- Rebola, N.; Simões, A.P.; Canas, P.M.; Tomé, A.R.; Andrade, G.M.; Barry, C.E.; Agostinho, P.M.; Lynch, M.A.; Cunha, R.A..
"Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction". Journal of Neurochemistry
117 1 (2011): 100-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952548073&partnerID=MN8TOARS.
10.1111/j.1471-4159.2011.07178.x
- Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P.. "Pre-synaptic adenosine A2A receptors
control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission". Journal of Neurochemistry
116 2 (2011): 273-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS.
10.1111/j.1471-4159.2010.07101.x
- Agostinho, P.; Cunha, R.A.; Oliveira, C.. "Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease".
Current Pharmaceutical Design 16 25 (2010): 2766-2778. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957970155&partnerID=MN8TOARS.
- Cunha, R.A.; Agostinho, P.M.. "Chronic caffeine consumption prevents memory disturbance in different animal models of memory
decline". Journal of Alzheimer's Disease 20 SUPPL.1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954537925&partnerID=MN8TOARS.
10.3233/JAD-2010-1408
- Mendonça, A.; Cunha, R.A.. "Therapeutic opportunities for caffeine in Alzheimer's disease and other neurodegenerative disorders".
Journal of Alzheimer's Disease 20 SUPPL.1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956222935&partnerID=MN8TOARS.
10.3233/JAD-2010-01420
- de Mendonça, A.; Cunha, R.A.. "Putative neuroprotective effects of caffeine in clinical trials. Concluding remarks.". Journal
of Alzheimer's disease : JAD 20 Suppl 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956212740&partnerID=MN8TOARS.
- Costenla, A.R.; Cunha, R.A.; De Mendonça, A.. "Caffeine, adenosine receptors, and synaptic plasticity". Journal of Alzheimer's
Disease 20 SUPPL.1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956219897&partnerID=MN8TOARS.
10.3233/JAD-2010-091384
- Cognato, G.P.; Agostinho, P.M.; Hockemeyer, J.; Müller, C.E.; Souza, D.O.; Cunha, R.A.. "Caffeine and an adenosine A2A receptor
antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life". Journal
of Neurochemistry 112 2 (2010): 453-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-72849150168&partnerID=MN8TOARS.
10.1111/j.1471-4159.2009.06465.x
- Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F.. "Diabetes differentially affects the
content of exocytotic proteins in hippocampal and retinal nerve terminals". Neuroscience 169 4 (2010): 1589-1600. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955414626&partnerID=MN8TOARS.
10.1016/j.neuroscience.2010.06.021
- Canas, P.M.; Porciúncula, L.O.; Cunha, G.M.A.; Silva, C.G.; Machado, N.J.; Oliveira, J.M.A.; Oliveira, C.R.; Cunha, R.A..
"Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by ß-amyloid peptides via p38 mitogen-activated
protein kinase pathway". Journal of Neuroscience 29 47 (2009): 14741-14751. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449208698&partnerID=MN8TOARS.
10.1523/JNEUROSCI.3728-09.2009
- Velloso, N.A.; Dalmolin, G.D.; Gomes, G.M.; Rubin, M.A.; Canas, P.M.; Cunha, R.A.; Mello, C.F.. "Spermine improves recognition
memory deficit in a rodent model of Huntington's disease". Neurobiology of Learning and Memory 92 4 (2009): 574-580.
http://www.scopus.com/inward/record.url?eid=2-s2.0-69949090346&partnerID=MN8TOARS.
10.1016/j.nlm.2009.07.006
- Quiroz, C.; Luján, R.; Uchigashima, M.; Simoes, A.P.; Lerner, T.N.; Borycz, J.; Kachroo, A.; et al. "Key modulatory role of
presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway". TheScientificWorldJournal
9 (2009): 1321-1344. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949159248&partnerID=MN8TOARS.
10.1100/tsw.2009.143
- Duarte, J.M.N.; Carvalho, R.A.; Cunha, R.A.; Gruetter, R.. "Caffeine consumption attenuates neurochemical modifications in
the hippocampus of streptozotocin-induced diabetic rats". Journal of Neurochemistry 111 2 (2009): 368-379. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349338971&partnerID=MN8TOARS.
10.1111/j.1471-4159.2009.06349.x
- Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A.. "Modification upon aging of the density of presynaptic
modulation systems in the hippocampus". Neurobiology of Aging 30 11 (2009): 1877-1884. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS.
10.1016/j.neurobiolaging.2008.01.003
- Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A.. "N-acyldopamines control striatal
input terminals via novel ligand-gated cation channels". Neuropharmacology 56 3 (2009): 676-683. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS.
10.1016/j.neuropharm.2008.12.001
- Gomes, C.A.R.V.; Simões, P.F.; Canas, P.M.; Quiroz, C.; Sebastião, A.M.; Ferré, S.; Cunha, R.A.; Ribeiro, J.A.. "GDNF control
of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors". Journal of Neurochemistry
108 5 (2009): 1208-1219. http://www.scopus.com/inward/record.url?eid=2-s2.0-59449098460&partnerID=MN8TOARS.
10.1111/j.1471-4159.2009.05876.x
- Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A..
"GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic
receptors, modulating Ca2+ influx". Cell Calcium 44 6 (2008): 521-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS.
10.1016/j.ceca.2008.03.006
- Cunha, R.A.. "Caffeine, adenosine receptors, memory and Alzheimer's disease | Cafeína, receptores de adenosina, memoria y
enfermedad de Alzheimer". Medicina Clinica 131 20 (2008): 790-795. http://www.scopus.com/inward/record.url?eid=2-s2.0-63549108150&partnerID=MN8TOARS.
10.1016/S0025-7753(08)75506-4
- Cunha, R.A.; Ferré, S.; Vaugeois, J.-M.; Chen, J.-F.. "Potential therapeutic interest of adenosine A2A receptors in Psychiatric
disorders". Current Pharmaceutical Design 14 15 (2008): 1512-1524. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349125085&partnerID=MN8TOARS.
10.2174/138161208784480090
- Rodrigues, R.J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A.. "Modification of adenosine modulation of acetylcholine
release in the hippocampus of aged rats". Neurobiology of Aging 29 10 (2008): 1597-1601. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS.
10.1016/j.neurobiolaging.2007.03.025
- Cunha, G.M.A.; Canas, P.M.; Melo, C.S.; Hockemeyer, J.; Müller, C.E.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A2A receptor
blockade prevents memory dysfunction caused by ß-amyloid peptides but not by scopolamine or MK-801". Experimental Neurology
210 2 (2008): 776-781. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136710&partnerID=MN8TOARS.
10.1016/j.expneurol.2007.11.013
- Ferré, S.; Quiroz, C.; Woods, A.S.; Cunha, R.; Popoli, P.; Ciruela, F.; Lluis, C.; et al. "An update on adenosine A2A-dopamine
D2 receptor interactions: Implications for the function of G protein-coupled receptors". Current Pharmaceutical Design
14 15 (2008): 1468-1474. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349126631&partnerID=MN8TOARS.
10.2174/138161208784480108
- Shen, H.-Y.; Coelho, J.E.; Ohtsuka, N.; Canas, P.M.; Day, Y.-J.; Huang, Q.-Y.; Rebola, N.; et al. "A critical role of the
adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum
and forebrain A2A receptor knock-outs". Journal of Neuroscience 28 12 (2008): 2970-2975. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136068&partnerID=MN8TOARS.
10.1523/JNEUROSCI.5255-07.2008
- Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M.. "Electrophysiological and
immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells". Pancreas 36 3 (2008): 279-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS.
10.1097/MPA.0b013e31815a8473
- Rebola, N.; Lujan, R.; Cunha, R.A.; Mulle, C.. "Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs
at Hippocampal Mossy Fiber Synapses". Neuron 57 1 (2008): 121-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549021899&partnerID=MN8TOARS.
10.1016/j.neuron.2007.11.023
- Yu, L.; Shen, H.-Y.; Coelho, J.E.; Araújo, I.M.; Huang, Q.-Y.; Day, Y.-J.; Rebola, N.; et al. "Adenosine A2A receptor antagonists
exert motor and neuroprotective effects by distinct cellular mechanisms". Annals of Neurology 63 3 (2008): 338-346.
http://www.scopus.com/inward/record.url?eid=2-s2.0-41849085227&partnerID=MN8TOARS.
10.1002/ana.21313
- Cunha, R.A.. "Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven
volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity". Neurochemistry International
52 1 (2008): 65-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849073199&partnerID=MN8TOARS.
10.1016/j.neuint.2007.06.026
- Schiffmann, S.N.; Fisone, G.; Moresco, R.; Cunha, R.A.; Ferré, S.. "Adenosine A2A receptors and basal ganglia physiology".
Progress in Neurobiology 83 5 (2007): 277-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-36148983766&partnerID=MN8TOARS.
10.1016/j.pneurobio.2007.05.001
- Duarte, J.M.N.; Oses, J.P.; Rodrigues, R.J.; Cunha, R.A.. "Modification of purinergic signaling in the hippocampus of streptozotocin-induced
diabetic rats". Neuroscience 149 2 (2007): 382-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS.
10.1016/j.neuroscience.2007.08.005
- Ferré, S.; Ciruela, F.; Quiroz, C.; Luján, R.; Popoli, P.; Cunha, R.A.; Agnati, L.F.; et al. "Adenosine receptor heteromers
and their integrative role in striatal function". TheScientificWorldJournal 7 SUPPL. 2 (2007): 74-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249058539&partnerID=MN8TOARS.
10.1100/tsw.2007.211
- Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A.. "Anandamide and NADA bi-directionally
modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus". British Journal of Pharmacology 151
4 (2007): 551-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS.
10.1038/sj.bjp.0707252
- Silva, C.G.; Porciúncula, L.O.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A.. "Blockade of adenosine A2A receptors prevents staurosporine-induced
apoptosis of rat hippocampal neurons". Neurobiology of Disease 27 2 (2007): 182-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447634291&partnerID=MN8TOARS.
10.1016/j.nbd.2007.04.018
- Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al. "Differential glutamate-dependent
and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments".
Journal of Neurochemistry 101 2 (2007): 355-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS.
10.1111/j.1471-4159.2006.04386.x
- Rebola, N.; Sachidhanandam, S.; Perrais, D.; Cunha, R.A.; Mulle, C.. "Short-term plasticity of kainate receptor-mediated EPSCs
induced by NMDA receptors at hippocampal mossy fiber synapses". Journal of Neuroscience 27 15 (2007): 3987-3993. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247146060&partnerID=MN8TOARS.
10.1523/JNEUROSCI.5182-06.2007
- Duarte, J.M.N.; Cunha, R.A.; Carvalho, R.A.. "Different metabolism of glutamatergic and GABAergic compartments in superfused
hippocampal slices characterized by nuclear magnetic resonance spectroscopy". Neuroscience 144 4 (2007): 1305-1313.
http://www.scopus.com/inward/record.url?eid=2-s2.0-33846274201&partnerID=MN8TOARS.
10.1016/j.neuroscience.2006.11.027
- Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A.. "Increase of cannabinoid CB1 receptor
density in the hippocampus of streptozotocin-induced diabetic rats". Experimental Neurology 204 1 (2007): 479-484.
http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS.
10.1016/j.expneurol.2006.11.013
- Dall'Igna, O.P.; Fett, P.; Gomes, M.W.; Souza, D.O.; Cunha, R.A.; Lara, D.R.. "Caffeine and adenosine A2a receptor antagonists
prevent ß-amyloid (25-35)-induced cognitive deficits in mice". Experimental Neurology 203 1 (2007): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751427701&partnerID=MN8TOARS.
10.1016/j.expneurol.2006.08.008
- Köfalvi, A.; Oliveira, C.R.; Cunha, R.A.. "Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve
terminals". Neuroscience Letters 403 1-2 (2006): 151-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS.
10.1016/j.neulet.2006.04.030
- Cunha, G.M.A.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A.. "Increased density and synapto-protective effect of adenosine A2A
receptors upon sub-chronic restraint stress". Neuroscience 141 4 (2006): 1775-1781. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747160404&partnerID=MN8TOARS.
10.1016/j.neuroscience.2006.05.024
- Coelho, J.E.; Rebola, N.; Fragata, I.; Ribeiro, J.A.; De Mendonça, A.; Cunha, R.A.. "Hypoxia-induced desensitization and internalization
of adenosine A 1 receptors in the rat hippocampus". Neuroscience 138 4 (2006): 1195-1203. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644838682&partnerID=MN8TOARS.
10.1016/j.neuroscience.2005.12.012
- Pereira, D.B.; Rebola, N.; Rodrigues, R.J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B.. "TrkB receptors modulation of glutamate
release is limited to a subset of nerve terminals in the adult rat hippocampus". Journal of Neuroscience Research 83
5 (2006): 832-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS.
10.1002/jnr.20784
- Duarte, J.M.N.; Oliveira, C.R.; Ambrósio, A.F.; Cunha, R.A.. "Modification of adenosine A1 and A2A receptor density in the
hippocampus of streptozotocin-induced diabetic rats". Neurochemistry International 48 2 (2006): 144-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244450466&partnerID=MN8TOARS.
10.1016/j.neuint.2005.08.008
- Ciruela, F.; Casadó, V.; Rodrigues, R.J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al. "Presynaptic control of
striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers". Journal of Neuroscience 26 7 (2006):
2080-2087. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS.
10.1523/JNEUROSCI.3574-05.2006
- Ciruela, F.; Ferré, S.; Casadó, V.; Cortés, A.; Cunha, R.A.; Lluis, C.; Franco, R.. "Heterodimeric adenosine receptors: A
device to regulate neurotransmitter release". Cellular and Molecular Life Sciences 63 21 (2006): 2427-2431. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750882222&partnerID=MN8TOARS.
10.1007/s00018-006-6216-2
- Rodrigues, R.J.; Almeida, T.; De Mendonça, A.; Cunha, R.A.. "Interaction between P2X and nicotinic acetylcholine receptors
in glutamate nerve terminals of the rat hippocampus". Journal of Molecular Neuroscience 30 1-2 (2006): 173-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS.
10.1385/JMN:30:1:173
- Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G.. "CB1 receptor
antagonism increases hippocampal acetylcholine release: Site and mechanism of action". Molecular Pharmacology 70 4
(2006): 1236-1245. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS.
10.1124/mol.106.024661
- Ferré S; Borycz J; Goldberg SR; Hope BT; Morales M; Lluis C; Franco R; Ciruela F; Cunha R. "Role of adenosine in the control
of homosynaptic plasticity in striatal excitatory synapses.". (2005): http://europepmc.org/abstract/med/16385640.
10.1142/S0219635205000987
- Rebola N; Rodrigues RJ; Oliveira CR; Cunha RA. "Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced
toxicity in cortical cultured neurons.". (2005): http://europepmc.org/abstract/med/16011860.
10.1016/j.neuint.2005.05.009
- Rodrigues RJ; Almeida T; Richardson PJ; Oliveira CR; Cunha RA. "Dual presynaptic control by ATP of glutamate release via facilitatory
P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.". (2005): http://europepmc.org/abstract/med/16000618.
10.1523/JNEUROSCI.0628-05.2005
- Cunha RA. "Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.". (2005):
http://europepmc.org/abstract/med/18404497.
10.1007/s11302-005-0649-1
- Pinto-Duarte A; Coelho JE; Cunha RA; Ribeiro JA; Sebastião AM. "Adenosine A2A receptors control the extracellular levels of
adenosine through modulation of nucleoside transporters activity in the rat hippocampus.". (2005): http://europepmc.org/abstract/med/15836618.
10.1111/j.1471-4159.2005.03071.x
- Köfalvi A; Rodrigues RJ; Ledent C; Mackie K; Vizi ES; Cunha RA; Sperlágh B. "Involvement of cannabinoid receptors in the regulation
of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.". (2005): http://europepmc.org/abstract/med/15772347.
10.1523/JNEUROSCI.4232-04.2005
- Rodrigues RJ; Alfaro TM; Rebola N; Oliveira CR; Cunha RA. "Co-localization and functional interaction between adenosine A(2A)
and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.". (2005): http://europepmc.org/abstract/med/15659214.
10.1111/j.1471-4159.2004.02887.x
- Fredholm BB; Chen JF; Cunha RA; Svenningsson P; Vaugeois JM. "Adenosine and brain function.". (2005): http://europepmc.org/abstract/med/15797469.
10.1016/S0074-7742(05)63007-3
- Rebola N; Porciúncula LO; Lopes LV; Oliveira CR; Soares-da-Silva P; Cunha RA. "Long-term effect of convulsive behavior on
the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.". (2005): http://europepmc.org/abstract/med/15987272.
10.1111/j.1528-1167.2005.01026.x
- Rebola, N.; Porciúncula, L.O.; Lopes, L.V.; Oliveira, C.R.; Soares-Da-Silva, P.; Cunha, R.A.. "Long-term effect of convulsive
behavior on the density of adenosine A 1 and A 2A receptors in the rat cerebral cortex". Epilepsia 46 SUPPL. 5 (2005):
159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844450198&partnerID=MN8TOARS.
- Rebola, N.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A.. "Different synaptic and subsynaptic localization of adenosine A2A receptors
in the hippocampus and striatum of the rat". Neuroscience 132 4 (2005): 893-903. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344362097&partnerID=MN8TOARS.
10.1016/j.neuroscience.2005.01.014
- Rebola, N.; Rodrigues, R.J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A1 and A2A receptors are
co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus". Neuroscience
133 1 (2005): 79-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS.
10.1016/j.neuroscience.2005.01.054
- Alfaro, T.M.; Vigia, E.; Oliveira, C.R.; Cunha, R.A.. "Effect of free radicals on adenosine A2A and dopamine D 2 receptors
in the striatum of young adult and aged rats". Neurochemistry International 45 5 (2004): 733-738. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042601106&partnerID=MN8TOARS.
10.1016/j.neuint.2004.02.003
- Cunha, R.A.; Ribeiro, J.A.; Malva, J.O.. "Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus
are inhibited by arachidonic acid". Neurochemistry International 44 5 (2004): 371-379. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345304227&partnerID=MN8TOARS.
10.1016/S0197-0186(03)00167-0
- Halldner, L.; Lopes, L.V.; Daré, E.; Lindström, K.; Johansson, B.; Ledent, C.; Cunha, R.A.; Fredholm, B.B.. "Binding of adenosine
receptor ligands to brain of adenosine receptor knock-out mice: Evidence that CGS 21680 binds to A1 receptors in hippocampus".
Naunyn-Schmiedeberg's Archives of Pharmacology 370 4 (2004): 270-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244262300&partnerID=MN8TOARS.
10.1007/s00210-004-0970-1
- Lopes, L.V.; Halldner, L.; Rebola, N.; Johansson, B.; Ledent, C.; Chen, J.F.; Fredholm, B.B.; Cunha, R.A.. "Binding of the
prototypical adenosine A 2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A 1 and A 2A receptor knockout
mice". British Journal of Pharmacology 141 6 (2004): 1006-1014. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942472484&partnerID=MN8TOARS.
10.1038/sj.bjp.0705692
- Almeida, T.; Rodrigues, R.J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A.. "Purinergic P2 receptors trigger adenosine release
leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices". Neuroscience
122 1 (2003): 111-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS.
10.1016/S0306-4522(03)00523-2
- Malva, J.O.; Silva, A.P.; Cunha, R.A.. "Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role
of kainate, adenosine and neuropeptide Y receptors". Neurochemical Research 28 10 (2003): 1501-1515. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141593557&partnerID=MN8TOARS.
10.1023/A:1025618324593
- Rebola, N.; Pinheiro, P.C.; Oliveira, C.R.; Malva, J.O.; Cunha, R.A.. "Subcellular localization of adenosine A1 receptors
in nerve terminals and synapses of the rat hippocampus". Brain Research 987 1 (2003): 49-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142106470&partnerID=MN8TOARS.
10.1016/S0006-8993(03)03247-5
- Rebola, N.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; Oliveira, C.R.; Soares-da-Silva, P.; De Mendonça, A.; Cunha,
R.A.. "Decrease of adenosine A1 receptor density and of adenosine neuromodulation the hippocampus of kindled rats". European
Journal of Neuroscience 18 4 (2003): 820-828. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042819806&partnerID=MN8TOARS.
10.1046/j.1460-9568.2003.02815.x
- Lopes, L.V.; Rebola, N.; Pinheiro, P.C.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A3 receptors are located
in neurons of the rat hippocampus". NeuroReport 14 12 (2003): 1645-1648. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141645291&partnerID=MN8TOARS.
10.1097/00001756-200308260-00021
- Fredholm, B.B.; Cunha, R.A.; Svenningsson, P.. "Pharmacology of adenosine A2A receptors and therapeutic applications.". Current
topics in medicinal chemistry 3 4 (2003): 413-426. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038143146&partnerID=MN8TOARS.
- Rebola, N.; Sebastião, A.M.; De Mendonca, A.; Oliveira, C.R.; Ribeiro, J.A.; Cunha, R.A.. "Enhanced adenosine A2A receptor
facilitation of synaptic transmission in the hippocampus of aged rats". Journal of Neurophysiology 90 2 (2003): 1295-1303.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0042817860&partnerID=MN8TOARS.
10.1152/jn.00896.2002
- Magalhães-Cardoso, M.T.; Pereira, M.F.; Oliveira, L.; Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sá, P.. "Ecto-AMP deaminase blunts
the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings". Journal of Physiology
549 2 (2003): 399-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038511040&partnerID=MN8TOARS.
- Cunha, R.A.. "Heteroexchange of purines in the hippocampus: Mixing-up or messing-up ATP and adenosine". British Journal
of Pharmacology 139 3 (2003): 473-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038002126&partnerID=MN8TOARS.
- Lopes, L.V.; Rebola, N.; Costenla, A.R.; Halldner, L.; Jacobson, M.A.; Oliveira, C.R.; Richardson, P.J.; et al. "Adenosine
A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors". Drug Development Research 58 4 (2003):
428-438. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038388748&partnerID=MN8TOARS.
10.1002/ddr.10188
- Dall'lgna, O.P.; Porciúncula, L.O.; Souza, D.O.; Cunha, R.A.; Lara, D.R.. "Neuroprotection by caffeine and adenosine A 2A
receptor blockade of ß-amyloid neurotoxicity". British Journal of Pharmacology 138 7 (2003): 1207-1209. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038415954&partnerID=MN8TOARS.
10.1038/sj.bjp.0705185
- Santos, D.A.; Salgado, A.I.; Cunha, R.A.. "ATP is released from nerve terminals and from activated muscle fibres on stimulation
of the rat phrenic nerve". Neuroscience Letters 338 3 (2003): 225-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037422297&partnerID=MN8TOARS.
10.1016/S0304-3940(02)01419-2
- Almeida, C.G.; De Mendonça, A.; Cunha, R.A.; Ribeiro, J.A.. "Adenosine promotes neuronal recovery from reactive oxygen species
induced lesion in rat hippocampal slices". Neuroscience Letters 339 2 (2003): 127-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457352&partnerID=MN8TOARS.
10.1016/S0304-3940(02)01478-7
- Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O.. "Solubilization and immunological
identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus". Neuroscience
Letters 336 2 (2003): 97-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS.
10.1016/S0304-3940(02)01217-X
- Rebola, N.; Oliveira, C.R.; Cunha, R.A.. "Transducing system operated by adenosine A2A receptors to facilitate acetylcholine
release in the rat hippocampus". European Journal of Pharmacology 454 1 (2002): 31-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036843638&partnerID=MN8TOARS.
10.1016/S0014-2999(02)02475-5
- Cunha, R.A.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; De Mendonça, A.; Sebastião, A.M.; Ribeiro, J.A.. "Effects
of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal
slices". Pharmacology and Toxicology 90 4 (2002): 208-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036251881&partnerID=MN8TOARS.
10.1034/j.1600-0773.2002.900407.x
- Lopes, L.V.; Cunha, R.A.; Kull, B.; Fredholm, B.B.; Ribeiro, J.A.. "Adenosine A2A receptor facilitation of hippocampal synaptic
transmission is dependent on tonic A1 receptor inhibition". Neuroscience 112 2 (2002): 319-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037129938&partnerID=MN8TOARS.
10.1016/S0306-4522(02)00080-5
- Villa de Brito, M.T.; Canto, A.; Duarte Correia, J.H.; Cunha, R.A.; Marques, M.C.. "Adenosine A 2A receptors in portal hypertension:
Their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits". British Journal of Pharmacology
135 5 (2002): 1324-1330. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036196797&partnerID=MN8TOARS.
- Díaz-Hernández, M.; Fátima Pereira, M.; Pintor, J.; Cunha, R.A.; Ribeiro, J.A.; Miras-Portugal, M.T.. "Modulation of the rat
hippocampal dinucleotide receptor by adenosine receptor activation". Journal of Pharmacology and Experimental Therapeutics
301 2 (2002): 441-450. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036232217&partnerID=MN8TOARS.
10.1124/jpet.301.2.441
- Cunha, R.A.; Dolores Constantino, M.; Fonseca, E.; Ribeiro, J.A.. "Age-dependent decrease in adenosine A 1 receptor binding
sites in the rat brain: Effect of cis unsaturated free fatty acids". European Journal of Biochemistry 268 10 (2001):
2939-2947. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034830959&partnerID=MN8TOARS.
10.1046/j.1432-1327.2001.02183.x
- Cunha, R.A.. "Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals". Neurochemical Research
26 8-9 (2001): 979-991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034753234&partnerID=MN8TOARS.
10.1023/A:1012392719601
- Bonifácio, M.J.; Sheridan, R.D.; Parada, A.; Cunha, R.A.; Patmore, L.; Soares-Da-Silva, P.. "Interaction of the novel anticonvulsant,
BIA 2-093, with voltage-gated sodium channels: Comparison with carbamazepine". Epilepsia 42 5 (2001): 600-608. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035013202&partnerID=MN8TOARS.
10.1046/j.1528-1157.2001.43600.x
- Cunha, R.A.. "Bringing the brain into the test tube: An experiment illustrating the effect of ethanol on nerve terminal viability".
Biochemistry and Molecular Biology Education 29 3 (2001): 105-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899059&partnerID=MN8TOARS.
10.1016/S1470-8175(01)00035-2
- Cunha, R.A.; Almeida, T.; Ribeiro, J.A.. "Parallel modification of adenosine extracellular metabolism and modulatory action
in the hippocampus of aged rats". Journal of Neurochemistry 76 2 (2001): 372-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035140223&partnerID=MN8TOARS.
10.1046/j.1471-4159.2001.00095.x
- Ribeiro, J.A.; Cunha-Reis, D.; Lopes, L.V.; Coelho, J.E.; Costenla, A.R.; Correia-de-Sá, P.; Cunha, R.A.; De Mendonça, A.;
Sebastiao, A.M.. "Adenosine receptor interactions in the hippocampus". Drug Development Research 52 1-2 (2001): 337-345.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035028567&partnerID=MN8TOARS.
10.1002/ddr.1132
- Cunha, R.A.. "Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different
sources and different receptors". Neurochemistry International 38 2 (2001): 107-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035255227&partnerID=MN8TOARS.
10.1016/S0197-0186(00)00034-6
- Cunha, R.A.; Ribeiro, J.A.. "ATP as a presynaptic modulator". Life Sciences 68 2 (2000): 119-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034554789&partnerID=MN8TOARS.
- Sebastião, A.M.; Cunha, R.A.; De Mendonça, A.; Ribeiro, J.A.. "Modification of adenosine modulation of synaptic transmission
in the hippocampus of aged rats". British Journal of Pharmacology 131 8 (2000): 1629-1634. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034531574&partnerID=MN8TOARS.
- Cunha, R.A.; Almeida, T.; Ribeiro, J.A.. "Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory
action in the rat hippocampus". Journal of Biological Chemistry 275 48 (2000): 37572-37581. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535956&partnerID=MN8TOARS.
10.1074/jbc.M003011200
- Pereira, M.F.; Hernández, M.D.; Pintor, J.; Miras-Portugal, M.T.; Cunha, R.A.; Ribeiro, J.A.. "Diadenosine polyphosphates
facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals". Brain Research 879 1-2 (2000):
50-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342472159&partnerID=MN8TOARS.
10.1016/S0006-8993(00)02726-8
- Cunha, R.A.; Cyrne, L.; Castanho, M.; Freire, A.P.. "Meeting Report - Biochemical Education at the University Level, Lisbon,
Portugal, October 30-31, 1999". Biochemistry and Molecular Biology Education 28 4 (2000): 234-237. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033744526&partnerID=MN8TOARS.
10.1016/S1470-8175(00)00008-4
- Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R.. "Adenosine A(2A) receptors regulate the extracellular accumulation
of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells". Experimental Eye Research 70
5 (2000): 577-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS.
10.1006/exer.1999.0815
- Salgado, A.I.; Cunha, R.A.; Ribeiro, J.A.. "Facilitation by P2 receptor activation of acetylcholine release from rat motor
nerve terminals: Interaction with presynaptic nicotinic receptors". Brain Research 877 2 (2000): 245-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034703241&partnerID=MN8TOARS.
10.1016/S0006-8993(00)02679-2
- Pereira, M.F.; Cunha, R.A.; Ribeiro, J.A.. "Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats".
Neurochemistry International 36 7 (2000): 563-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034214262&partnerID=MN8TOARS.
10.1016/S0197-0186(99)00164-3
- Cunha, R.A.; Ribeiro, J.A.. "Adenosine A(2A) receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus
requires protein kinase C but not protein kinase A activation". Neuroscience Letters 289 2 (2000): 127-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033624133&partnerID=MN8TOARS.
10.1016/S0304-3940(00)01295-7
- A. Cunha, R.; Malva, J.O.; Ribeiro, J.A.. "Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal
[3H]GABA release". FEBS Letters 469 2-3 (2000): 159-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034629239&partnerID=MN8TOARS.
10.1016/S0014-5793(00)01272-2
- Cunha, R.A.; Ribeiro, J.A.. "Purinergic modulation of [3H]GABA release from rat hippocampal nerve terminals". Neuropharmacology
39 7 (2000): 1156-1167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034064253&partnerID=MN8TOARS.
10.1016/S0028-3908(99)00237-3
- Cunha, R.A.; Brendel, P.; Zimmermann, H.; Ribeiro, J.A.. "Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve
terminals of different areas of the rat hippocampus". Journal of Neurochemistry 74 1 (2000): 334-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033970847&partnerID=MN8TOARS.
10.1046/j.1471-4159.2000.0740334.x
- Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R.. "Adenosine modulation of D-[3H]aspartate
release in cultured retina cells exposed to oxidative stress". Neurochemistry International 36 3 (2000): 255-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS.
10.1016/S0197-0186(99)00113-8
- Benes, J.; Parada, A.; Figueiredo, A.A.; Alves, P.C.; Freitas, A.P.; Learmonth, D.A.; Cunha, R.A.; Garrett, J.; Soares-Da-Silva,
P.. "Anticonvulsant and sodium channel-blocking properties of novel 10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives".
Journal of Medicinal Chemistry 42 14 (1999): 2582-2587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566070&partnerID=MN8TOARS.
10.1021/jm980627g
- Cunha, R.A.; Malva, J.O.; Ribeiro, J.A.. "Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus". Molecular
Pharmacology 56 2 (1999): 429-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032793961&partnerID=MN8TOARS.
- Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex
is different from that of adenosine A1 and striatal A(2A) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology
359 4 (1999): 295-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032947295&partnerID=MN8TOARS.
10.1007/PL00005355
- Cunha, R.A.; Ribeiro, J.A.. "Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes". European
Journal of Neuroscience 11 6 (1999): 2171-2174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033047188&partnerID=MN8TOARS.
10.1046/j.1460-9568.1999.00661.x
- Almeida, T.; Cunha, R.A.; Ribeiro, J.A.. "Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus".
Brain Research 826 1 (1999): 104-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033599818&partnerID=MN8TOARS.
10.1016/S0006-8993(99)01267-6
- Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A1 receptor
responses". European Journal of Pharmacology 383 3 (1999): 395-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779092&partnerID=MN8TOARS.
10.1016/S0014-2999(99)00659-7
- Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "Cross talk between A1 and A(2A) adenosine receptors in the hippocampus and cortex
of young adult and old rats". Journal of Neurophysiology 82 6 (1999): 3196-3203. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033390941&partnerID=MN8TOARS.
- Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "Increase in the number, G protein coupling, and efficiency of facilitatory adenosine
A(2A) receptors in the limbic cortex, but not striatum, of aged rats". Journal of Neurochemistry 73 4 (1999): 1733-1738.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032863555&partnerID=MN8TOARS.
10.1046/j.1471-4159.1999.731733.x
- Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A.. "Adenine nucleotides as inhibitors of synaptic transmission:
Role of localised ectonucleotidases". Progress in Brain Research 120 (1999): 183-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS.
- Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular
catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors". Journal of Neuroscience
18 6 (1998): 1987-1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032521330&partnerID=MN8TOARS.
- Cunha, R.A.; Foster, T.C.; Norris, C.M.; Verkhratsky, A.; Toescu, E.C.. "On slices, synaptosomes and dissociated neurones
to study in vitro ageing physiology (multiple letters)". Trends in Neurosciences 21 7 (1998): 286-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798434&partnerID=MN8TOARS.
- Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "ZM241385 is an antagonist of the facilitatory responses produced by the A(2A)
adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus". British Journal of Pharmacology 122 7 (1997):
1279-1284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030734490&partnerID=MN8TOARS.
- Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "Inhibition of [3H]¿-aminobutyric acid release by kainate receptor activation
in rat hippocampal synaptosomes". European Journal of Pharmacology 323 2-3 (1997): 167-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030610655&partnerID=MN8TOARS.
10.1016/S0014-2999(97)00043-5
- Gonçalves, M.L.; Cunha, R.A.; Ribeiro, J.A.. "Adenosine A(2A) receptors facilitate 45Ca2+ uptake through class A calcium channels
in rat hippocampal CA3 but not CA1 synaptosomes". Neuroscience Letters 238 1-2 (1997): 73-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031283080&partnerID=MN8TOARS.
10.1016/S0304-3940(97)00803-3
- Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sa, P.; Sebastiao, A.M.. "Purinergic regulation of acetylcholine release". Progress
in Brain Research 109 (1996): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030474316&partnerID=MN8TOARS.
- Cunha, R.A.; Johansson, B.; Constantino, M.D.; Sebastião, A.M.; Fredholm, B.B.. "Evidence for high-affinity binding sites
for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal
A2A receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 353 3 (1996): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670460&partnerID=MN8TOARS.
- Cunha, R.A.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Preferential release of ATP and its extracellular catabolism as
a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices". Journal of Neurochemistry
67 5 (1996): 2180-2187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029819083&partnerID=MN8TOARS.
- Ribeiro, J.A.; De Mendonça, A.; Correia-de-Sá, P.; Cunha, R.A.; Sebastião, A.M.. "Purinoceptors and synaptic plasticity".
Drug Development Research 39 3-4 (1996): 353-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030435849&partnerID=MN8TOARS.
- Cunha, R.A.; Correia-de-Sá, P.; Sebastião, A.M.; Ribeiro, J.A.. "Preferential activation of excitatory adenosine receptors
at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides". British Journal of
Pharmacology 119 2 (1996): 253-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029844019&partnerID=MN8TOARS.
- Cunha, R.A.; Johansson, B.; Fredholm, B.B.; Alexandre Ribeiro, J.; Sebastião, A.M.. "Adenosine A2A receptors stimulate acetylcholine
release from nerve terminals of the rat hippocampus". Neuroscience Letters 196 1-2 (1995): 41-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028984662&partnerID=MN8TOARS.
- Cunha, R.A.; Constantino, M.D.; Sebastiao, A.M.; Ribeiro, J.A.. "Modification of A1 and A(2a) adenosine receptor binding in
aged striatum, hippocampus and cortex of the rat". NeuroReport 6 11 (1995): 1583-1588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028983106&partnerID=MN8TOARS.
- Malva, J.O.; Ambrósio, A.F.; Cunha, R.A.; Ribeiro, J.A.; Carvalho, A.P.; Carvalho, C.M.. "A functionally active presynaptic
high-affinity kainate receptor in the rat hippocampal CA3 subregion". Neuroscience Letters 185 2 (1995): 83-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912732&partnerID=MN8TOARS.
10.1016/0304-3940(94)11230-G
- Cunha, R.A.; Johansson, B.; van der Ploeg, I.; Sebastião, A.M.; Alexandre Ribeiro, J.; Fredholm, B.B.. "Evidence for functionally
important adenosine A2a receptors in the rat hippocampus". Brain Research 649 1-2 (1994): 208-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028342730&partnerID=MN8TOARS.
- Cunha, R.A.; Milusheva, E.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Excitatory and inhibitory effects of A1 and A2A adenosine
receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus". Journal
of Neurochemistry 63 1 (1994): 207-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028241057&partnerID=MN8TOARS.
- Cunha, R.A.; Ribeiro, J.A.; Sebastiao, A.M.. "Purinergic modulation of the evoked release of [3H]Acetylcholine from the hippocampus
and cerebral cortex of the rat: Role of the ectonucleotidases". European Journal of Neuroscience 6 1 (1994): 33-42.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028031731&partnerID=MN8TOARS.
10.1111/j.1460-9568.1994.tb00245.x
- Cunha, R.A.; Sebastiao, A.M.. "Adenosine and adenine nucleotides are independently released from both the nerve terminals
and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog". Pflugers Archiv European
Journal of Physiology 424 5-6 (1993): 503-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027250345&partnerID=MN8TOARS.
- Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus
but not in the cerebral cortex of the rat". Journal of Neurochemistry 59 2 (1992): 657-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026660013&partnerID=MN8TOARS.
10.1111/j.1471-4159.1992.tb09420.x
- Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Relative contribution of nerve endings to the release of adenine nucleotides
in the innervated frog sartorius muscle". Nucleosides and Nucleotides 10 5 (1991): 1189-1190. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026070005&partnerID=MN8TOARS.
- Cunha, R.A.; Sebastiao, A.M.. "Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle
of the frog". European Journal of Pharmacology 197 1 (1991): 83-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025829211&partnerID=MN8TOARS.
- Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Blockade of AMP degradation allows the quantification of adenine nucleotides
released by nerve stimulation in the innervated frog sartorius muscle". European Journal of Pharmacology 183 5 (1990):
1684-1685. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025106547&partnerID=MN8TOARS.
10.1016/0014-2999(90)91979-L
- Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Separation of adenosine triphosphate and its degradation products in innervated
muscle of the frog by reverse phase high-performance liquid chromatography". Chromatographia 28 11-12 (1989): 610-612.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0001249211&partnerID=MN8TOARS.
10.1007/BF02260687
|
