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Rodrigo Antunes Cunha. Concluiu o(a) Doutoramento em Bioquímica em 1994/07 pelo(a) Universidade de Lisboa Faculdade de Ciências, Licenciatura em Bioquímica em 1989/06 pelo(a) Universidade de Lisboa Faculdade de Ciências e Licence em Clinical Research Associate em 1994/12 pelo(a) Rhône-Poulenc Rorer. É Professor Catedrático no(a) Universidade de Coimbra Faculdade de Medicina. Publicou 262 artigos em revistas especializadas. Possui 1 capítulo(s) de livros. Orientou 12 tese(s) de doutoramento e coorientou 25. Recebeu 9 prémio(s) e/ou homenagens. Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Neurociências. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: envelhecimento plasticidade; Alzheimer; memória; plasticidade sináptica; receptores; adenosina; .
Identificação

Identificação pessoal

Nome completo
Rodrigo Antunes Cunha

Nomes de citação

  • Cunha, Rodrigo A.

Identificadores de autor

Ciência ID
CF1A-8BED-B840
ORCID iD
0000-0003-2550-6422
Researcher Id
E-7475-2015
Scopus Author Id
7102879525

Endereços de correio eletrónico

  • rcunha@fmed.uc.pt (Profissional)

Moradas

  • CNC-Centro de Neurociências e Biologia Celular, Edifício da Faculdade de Medicina, Piso 1, Polo I, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Profissional)
  • FMUC, Instituto de Bioquímica, Unidade Central, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B2) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B2) Utilizador independente (B1)
Italiano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
2008/12 - 2008/12
Concluído
Biomedicina (Especialização pós-licenciatura)
Especialização em Fisiologia do Envelhecimento
Universidade de Coimbra Faculdade de Medicina, Portugal
aprovado por unanimidade
1995/01 - 1996/09
Concluído
Neurosciences (Pós-doutoramento)
Especialização em Neuropharmacology
Karolinska Institutet, Suécia
1994/03 - 1994/12
Concluído
Clinical Research Associate (Licence)
Rhône-Poulenc Rorer, França
aprovado
1990/01 - 1994/07
Concluído
Bioquímica (Doutoramento)
Especialização em Farmacologia
Universidade de Lisboa Faculdade de Ciências, Portugal
"Origem e Função Neuromoduladora da Adenosina no Sistema Nervoso" (TESE/DISSERTAÇÃO)
distinção e louvor
1984/10 - 1989/06
Concluído
Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Caracterização do catabolismo extracelular de nucleótidos de adenina na junção neuromuscular de rã" (TESE/DISSERTAÇÃO)
17 / 20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
1995/03 - 1996/09 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
1991/01 - 1993/12 Estagiário de Investigação (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Gulbenkian de Ciência, Portugal
1989/09 - 1990/12 Estagiário de Investigação (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2019/09 - Atual Professor Catedrático (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2004/03 - 2019/08 Professor Associado (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2001/03 - 2004/03 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
1996/10 - 2001/02 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
1994/04 - 1995/02 Clinical Research Associate Rhône-Poulenc Rorer, França
Rhône-Poulenc Rorer, França
Projetos

Bolsa

Designação Financiadores
2018/01 - 2019/12 Manipulação dos receptores A2A da adenosina para controlar os sintomas do síndrome de Angelman Fundação Amélia de Mello
2014/03 - 2015/09 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing Fundação para a Ciência e a Tecnologia, I.P.
2012/04 - 2014/09 Role of accumbens and amygdala in the control of chronic stress neuropathology Fundação para a Ciência e a Tecnologia, I.P.
2012/05 - 2014/08 Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/09 Role of ATP and its P2Y1 receptors in neuroprotection Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/02 Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage Fundação para a Ciência e a Tecnologia, I.P.
2007/05 - 2010/04 Interaction between nicotine and caffeine in the striatum. Relevance for Parkinson´s disease Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2009/10 EFFECT OF PURINES IN THE DEVELOPING HIPPOCAMPUS: CONSEQUENCES FOR THE ESTABLISHMENT OF CIRCUITS RELATED TO LEARNING AND MEMORY Fundação para a Ciência e a Tecnologia, I.P.
2007/06 - 2009/08 Role of extracellular ATP and characterization of purinergic receptors in the resistance of Candida albicans to macrophage attack Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2008/01 Relation between metabolic alterations in the hippocampus and memory deficits induced by diabetes Fundação para a Ciência e a Tecnologia, I.P.
2005/10 - 2007/12 Modification by chronic caffeine consumption of adenosine neuromodulation in the hippocampus - possible relevance for learning and memory Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 Characterization of purinergic receptors in hippocampal mossy fibers - role in epilepsy Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 Control by adenosine of neuro-inflammation Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 NEUROPROTECTION BY ADENOSINE RECEPTORS: COUPLING ENHANCED ADENOSINE FORMATION WITH A2A RECEPTOR BLOCKADE Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2019/12 - 2022/12 Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress
LCF/PR/HP17/52190001
Investigador responsável
Universidade de Coimbra, Portugal
Caixabank SA
Em curso
2020/01 - 2022/09 Adenosine A2A receptor antagonism affords integrated benefits for neurological symptoms of neurofibromatosis type I
W81XWH-18-1-0532NF170062
Investigador responsável
Universidade de Coimbra, Portugal
Congressionally Directed Medical Research Programs
Em curso
2018/05 - 2022/06 Strategies for healthy aging
CENTRO-01-0246-FEDER-000010
Universidade de Coimbra, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
Em curso
2020/01/01 - 2022/04/01 MIA-Portugal Multidisciplinary Institute of Ageing
Investigador responsável
Universidade de Coimbra, Portugal
Em curso
2018/07/01 - 2021/06/30 Recetores A2A da adenosina como desencadeadores de disfunção mnemónica na doença de Alzheimer: mecanismos e possibilidade terapêutica
PTDC/MED-NEU/31274/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07 - 2021/06 Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer’s disease: mechanisms and therapeutic propects
POCI-01-0145-FEDER-031274
Investigador responsável
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05 - 2019/06 Role of astrocytes in the control of memory – focus on adenosine A2A receptors
PTDC/NEU-NMC/4154/2014
Fundação para a Ciência e a Tecnologia
2014/10 - 2018/03 Role des récepteurs de l'adénosine dans la stabilisation des synapses Agence nationale de la recherche
2016/03 - 2017/08 Adenosine A2A receptors controls non-motor (mood and cognitive) symptoms in Parkinson’s disease
CAPES-FCT 8543/2014-03
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
2013/09 - 2017/05 Role of adenosine A2A receptors in the control of synaptic plasticity in the prefrontal cortex – relevance for attention deficit and hyperactivity disorders
159302-1-2009-1-NL-ERA MUNDUS-EMJD
European Commission
2014/10 - 2016/06 ROLE OF ADENOSINE A2A RECEPTORS IN THE ACCUMBENS AND AMYGDALA IN THE CONTROL OF CHRONIC STRESS NEUROPATHOLOGY
NARSAD Independent Investigator Grant
Investigador responsável
Universidade de Coimbra, Portugal
Brain and Behavior Research Foundation
Concluído
2014/03/01 - 2015/09/30 Ageing@Coimbra: Um Centro de Co-localização na Rede Europeia de Conhecimento e Inovação para o Envelhecimento Saudável e Ativo
EIT-KIC/IVE/0043/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/04/01 - 2014/09/30 Papel do accumbens e amigdala no controlo da neuropatologia causada por stress crónico
PTDC/SAU-NSC/122254/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/05/01 - 2014/08/31 Papel fisio-patológico da ecto-5`-nucleotidase - um novo alvo para neuroprotecção
PTDC/SAU-TOX/122005/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03/18 - 2012/09/17 Papel do ATP e dos seus receptores P2Y1 na neuroprotecção
PTDC/SAU-FCF/100423/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Zhou, Xuzhao; He, Yan; Xu, Tao; Wu, Zhaofa; Guo, Wei; Xu, Xi; Liu, Yuntao; et al. "40 Hz light flickering promotes sleep through cortical adenosine signaling". Cell Research (2024): http://dx.doi.org/10.1038/s41422-023-00920-1.
    Aceite para publicação • 10.1038/s41422-023-00920-1
  2. Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al. "The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". Molecular Psychiatry (2024): http://dx.doi.org/10.1038/s41380-024-02412-z.
    Aceite para publicação • 10.1038/s41380-024-02412-z
  3. Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata; Ana Paula Tavares; et al. "The striatum drives the ergogenic effects of caffeine". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-023-09922-5.
    10.1007/s11302-023-09922-5
  4. Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors". Cellular and Molecular Life Sciences (2023): https://doi.org/10.1007/s00018-023-04983-6.
    10.1007/s00018-023-04983-6
  5. Simões, Ana P.; Portes, Marina A. M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride L.; et al. "Adenosine A2A receptors control generalization of contextual fear in rats". Translational Psychiatry 13 1 (2023): http://dx.doi.org/10.1038/s41398-023-02613-0.
    Publicado • 10.1038/s41398-023-02613-0
  6. Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice". Glia (2023): https://doi.org/10.1002/glia.24384.
    10.1002/glia.24384
  7. Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease". Biomolecules (2023): https://doi.org/10.3390/biom13081173.
    10.3390/biom13081173
  8. Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda; et al. "Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest". Frontiers in Behavioral Neuroscience 17 (2023): http://dx.doi.org/10.3389/fnbeh.2023.1176382.
    Publicado • 10.3389/fnbeh.2023.1176382
  9. Pedro Valada; Sonja Hinz; Christin Vielmuth; Cátia R. Lopes; Rodrigo A. Cunha; Christa E. Müller; João Pedro Lopes. "The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-022-09899-7.
    10.1007/s11302-022-09899-7
  10. Fernandes, Mara Yone D.; Lopes, João Pedro; Silva, Henrique B.; Andrade, Geanne M.; Cunha, Rodrigo A.; Tomé, Angelo R.. "Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices". Neuroscience Letters 808 (2023): 137292. http://dx.doi.org/10.1016/j.neulet.2023.137292.
    Publicado • 10.1016/j.neulet.2023.137292
  11. Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation". Biomolecules (2023): https://doi.org/10.3390/biom13040715.
    10.3390/biom13040715
  12. Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences 24 8 (2023): 6968. http://dx.doi.org/10.3390/ijms24086968.
    Publicado • 10.3390/ijms24086968
  13. Wang, Muran; Li, Peijun; Li, Zewen; da Silva, Beatriz S.; Zheng, Wu; Xiang, Zhenghua; He, Yan; et al. "Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37601-x.
    Publicado • 10.1038/s41467-023-37601-x
  14. Gonçalves, Francisco Q.; Valada, Pedro; Matos, Marco; Cunha, Rodrigo A.; Tomé, Angelo R.. "Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals". Purinergic Signalling (2023): http://dx.doi.org/10.1007/s11302-023-09937-y.
    Aceite para publicação • 10.1007/s11302-023-09937-y
  15. Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; et al. "Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress". ACS Chemical Neuroscience 14 7 (2023): 1299-1309. http://dx.doi.org/10.1021/acschemneuro.2c00810.
    Publicado • 10.1021/acschemneuro.2c00810
  16. Jiang-Fan Chen; Doo-Sup Choi; Rodrigo A. Cunha. "Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility". Neuropharmacology (2023): https://doi.org/10.1016/j.neuropharm.2023.109421.
    10.1016/j.neuropharm.2023.109421
  17. Cátia R. Lopes; Andreia Oliveira; Ingride Luzio Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas". Biomolecules (2023): https://www.mdpi.com/2218-273X/13/1/106.
    10.3390/biom13010106
  18. Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-Pierre; et al. "Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease". Molecular Neurobiology 60 3 (2022): 1659-1674. http://dx.doi.org/10.1007/s12035-022-03162-1.
    Aceite para publicação • 10.1007/s12035-022-03162-1
  19. Dewaeles, Edmone; Carvalho, Ke´vin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan; et al. "Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects". Journal of Clinical Investigation 132 22 (2022): http://dx.doi.org/10.1172/jci152924.
    Publicado • 10.1172/jci152924
  20. Bruno Gonçalves Pinheiro; Diandra Araújo Luz; Sabrina de Carvalho Cartágenes; Luanna de Melo Pereira Fernandes; Sarah Viana Farias; Natália Harumi Correa Kobayashi; Enéas Andrade Fontes-Júnior; et al. "The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine". Pharmaceuticals (2022): https://doi.org/10.3390/ph15111323.
    10.3390/ph15111323
  21. Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Rodrigo A. Cunha. "CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232112826.
    10.3390/ijms232112826
  22. Pedro Valada; Sofia Alçada-Morais; Rodrigo A. Cunha; João Pedro Lopes. "Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231810510.
    10.3390/ijms231810510
  23. Xu, Xinli; Beleza, Rui O.; Gonçalves, Francisco Q.; Valbuena, Sergio; Alçada-Morais, Sofia; Gonçalves, Nélio; Magalhães, Joana; et al. "Adenosine A2A receptors control synaptic remodeling in the adult brain". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18884-4.
    Publicado • 10.1038/s41598-022-18884-4
  24. Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho. "Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04492-y.
    10.1007/s00018-022-04492-y
  25. Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; et al. "Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription". Journal of Clinical Investigation 132 12 (2022): http://dx.doi.org/10.1172/jci149371.
    Publicado • 10.1172/jci149371
  26. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas. "Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes". Purinergic Signalling (2022): https://doi.org/10.1007/s11302-022-09864-4.
    10.1007/s11302-022-09864-4
  27. Carvalho da Silva, António M.; Lemos, Cristina; Silva, Henrique B.; Ferreira, Ildete L.; Tomé, Angelo R.; Rego, A. Cristina; Cunha, Rodrigo A.. "Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.835885.
    Publicado • 10.3389/fnagi.2022.835885
  28. IJzerman, Adriaan P.; Jacobson, Kenneth A.; Müller, Christa E.; Cronstein, Bruce N.; Cunha, Rodrigo A.. "International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update". Pharmacological Reviews 74 2 (2022): 340-372. http://dx.doi.org/10.1124/pharmrev.121.000445.
    Publicado • 10.1124/pharmrev.121.000445
  29. Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré. "Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome". Molecules (2022): https://doi.org/10.3390/molecules27051489.
    10.3390/molecules27051489
  30. Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure". Journal of Neurochemistry (2022): https://doi.org/10.1111/jnc.15575.
    10.1111/jnc.15575
  31. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho. "Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-021-02538-z.
    10.1007/s12035-021-02538-z
  32. Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al. "Convergence of adenosine and GABA signaling for synapse stabilization during development". Science 374 6568 (2021): http://dx.doi.org/10.1126/science.abk2055.
    10.1126/science.abk2055
  33. Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, Marco; et al. "Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction". Neurobiology of Disease 157 (2021): 105441. http://dx.doi.org/10.1016/j.nbd.2021.105441.
    Publicado • 10.1016/j.nbd.2021.105441
  34. Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al. "l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory". The FASEB Journal 35 8 (2021): https://doi.org/10.1096/fj.202100336R.
    10.1096/fj.202100336R
  35. Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A.. "Adenosine A2A Receptors as Biomarkers of Brain Diseases". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.702581.
    10.3389/fnins.2021.702581
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  299. Cunha, R.A.; Foster, T.C.; Norris, C.M.; Verkhratsky, A.; Toescu, E.C.. "On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology (multiple letters)". Trends in Neurosciences 21 7 (1998): 286-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798434&partnerID=MN8TOARS.
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  304. Cunha, R.A.; Johansson, B.; Constantino, M.D.; Sebastião, A.M.; Fredholm, B.B.. "Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 353 3 (1996): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670460&partnerID=MN8TOARS.
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Capítulo de livro
  1. Canas, Paula M.; Cunha, Rodrigo A.. "Subsynaptic Membrane Fractionation". In Receptor and Ion Channel Detection in the Brain, 31-38. Springer US, 2021.
    Publicado • 10.1007/978-1-0716-1522-5_3
  2. Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Adenosine Receptors in Alzheimer’s Disease". In The Adenosine Receptors, 259-280. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-90808-3_11
  3. Prediger, Rui Daniel; Matheus, Filipe Carvalho; de Oliveira, Paulo Alexandre; Rial, Daniel; Moretti, Morgana; de Souza, Ana Cristina Guerra; Aguiar, Aderbal Silva; Cunha, Rodrigo A.. "Adenosine A2A Receptor-Mediated Control of Non-Motor Functions in Parkinson’s Disease". In Current Topics in Neurotoxicity, 183-205. Springer International Publishing, 2015.
    Publicado • 10.1007/978-3-319-20273-0_10
  4. Prediger, Rui Daniel; Matheus, Filipe Carvalho; de Oliveira, Paulo Alexandre; Rial, Daniel; Moretti, Morgana; de Souza, Ana Cristina Guerra; Aguiar, Aderbal Silva; Cunha, Rodrigo A.. "Adenosine A2A Receptor-Mediated Control of Non-Motor Functions in Parkinson’s Disease". In Current Topics in Neurotoxicity, 183-205. Springer International Publishing, 2015.
    Publicado • 10.1007/978-3-319-20273-0_10
  5. Gomes, Catarina; George, Jimmy; Chen, Jiang-Fan; Cunha, Rodrigo A.. "Role of Adenosine A2A Receptors in the Control of Neuroinflammation—Relevance for Parkinson’s Disease". In Current Topics in Neurotoxicity, 81-99. Springer International Publishing, 2015.
    Publicado • 10.1007/978-3-319-20273-0_5
  6. Rial, Daniel; Lara, Diogo R.; Cunha, Rodrigo A.. "The Adenosine Neuromodulation System in Schizophrenia". editado por Mori, A., 395-449. 2014.
    10.1016/b978-0-12-801022-8.00016-7
  7. Cunha, R. A.. "Adenosine Neuromodulation and Neuroprotection". In Handbook of Neurochemistry and Molecular Neurobiology, 255-273. Springer US, 2008.
    Publicado • 10.1007/978-0-387-30382-6_11
  8. Cunha, Rodrigo A.; Chen, Jiang-Fan; Sitkovsky, Michail V.. "Opposite Modulation of Peripheral Inflammation and Neuroinflammation by Adenosine A2A Receptors". In Interaction Between Neurons and Glia in Aging and Disease, 53-79. Springer US, 2007.
    Publicado • 10.1007/978-0-387-70830-0_3
Edição de livro
  1. Malva, João; Cunha, Rodrigo; Oliveira, Catarina R.. Interaction Between Neurons and Glia in Aging and Disease. Springer US. 2007.
    Publicado • 10.1007/978-0-387-70830-0

Outros

Outra produção
  1. Neuronal adenosine A2A receptors signal ergogenic effects of caffeine. 2020. Aderbal S Aguiar, Jr; Ana Elisa Speck; Paula M. Canas; Rodrigo A. Cunha. https://doi.org/10.1101/2020.04.02.021923.
    10.1101/2020.04.02.021923
Atividades

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Título / Tema
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2023/07/01 - Atual Avaliação do efeito neuroprotetor do corante Brilliant Blue G sobre camundongos submetidos ao modelo animal de Alzheimer induzido por estreptozotocina
Coorientador
Universidade Federal de Santa Catarina, Brasil
2022/02/01 - Atual O papel dos recetores purinérgicos do tipo P2X7 na deposição de proteínas aberrantes e desregulação de vias autofágicas no parkinsonismo experimental
Coorientador
Faculdade de Medicina da Universidade Federal do Ceara, Brasil
2022/01/01 - Atual Role of adenosine A2A receptors controlling synaptic senescence in ageing and Alzheimer´s disease
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/09 - 2023/12 Papel dos recetores de adenosina A2A astrocíticos no ontrolo da aquaporina 4 sob condições de stress crónico
Coorientador
Programa de Doutoramento em Ciências da Saúde (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/09/01 - 2022/09/01 Crosstalk entre recetores de adenosina A2A e conexina43 na doença de Alzheimer
Coorientador
Universidade de Coimbra, Portugal
2021/05 - 2022/09 Receptores CB1 e CB2 modulam o transporte de GABA em retinas embrionárias de galinha expostas à cafeína
Coorientador
Universidade Federal Fluminense, Brasil
2016/01/01 - 2020/12/31 Pathophysiological role of adenosinergic modulation within the basolateral complex of the amygdala
Orientador
Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas (Doutoramento)
Universidade de Coimbra, Portugal
2016/01/01 - 2019/12/31 The Role of Adenosine A2A Receptor in the Migration of Cortical Principal Neurons
Coorientador
Universidade de Coimbra, Portugal
2016/01 - 2019/01 The role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons
Coorientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/02 - 2018/10 O exercício físico reduz as discinesias induzidas por L-DOPA: investigação da neuroproteção e das modificações na metaplasticidade estriatal
Coorientador
Universidade Federal de Santa Catarina, Brasil
2015/01 - 2018/06 Caffeine, adenosine and acetylcholine and neuronal function in the cortex
Coorientador
Vrije Universiteit Amsterdam, Países Baixos
2015/01 - 2018/05 Physio-patological role of ecto-5’-nucleotidase – a new target for neuroprotection
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/03 - 2018/01 Adenosine receptors in inflammatory lung diseases
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/01 - 2017/04 Neurobiology of the Circadian Clock: Metabolism Control and Implications for Alzheimer´s disease
Coorientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014/01 - 2017/04 Role of the adenosinergic system in animal models of chronic stress and depression
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 - 2016/12 Avaliação do efeito neuroprotetor da guanosina em ratos submetidos a trauma crânio encefálico: envolvimento do sistema glutamatérgico e adenosinérgico
Coorientador
Universidade Federal de Santa Maria, Brasil
2013/07 - 2016/07 Metabolic modifications associated with memory deficits
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/06 - 2016/03 Recrutamento do receptor de adenosina A2B e ativação da via de AMPc-PI3K-ERK1/2 inibem a resposta de células dendríticas infectadas por Leishmania amazonensis
Coorientador
Universidade Federal de Ouro Preto, Brasil
2013/03 - 2016/01 Purines control neuron-glia interaction during neuroinflammation
Orientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/01 - 2016/01 Candida-host interaction: role of purines and adenosine A2A receptors
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/06 - 2015/09 Estudo do efeito neuroprotetor da berberina sobre o dano neuronal, comportamento motor e memória de ratos com degeneração nidro-estriatal por 6-OHDA
Coorientador
Faculdade de Medicina da Universidade Federal do Ceara, Brasil
2012/03 - 2015/07 Dissociando anedonia de outros sintomas da depressão na doença de Parkinson em um modelo experimental em ratos : papel do estriado dorsolateral e do córtex pré-frontal
Coorientador
Universidade Federal de Santa Catarina, Brasil
2012/01 - 2015/03 Efeito neuroprotetor do antagonismo dos receptores P2X7 no parkinsonismo experimental induzido por 6-OHDA
Coorientador
Faculdade de Medicina da Universidade Federal do Ceara, Brasil
2011/02 - 2014/12 Pathophysiology of hippocampal CA3 neurons in the APP/PS1 mouse model of Alzheimer's disease
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/01 - 2014/10 Characterization of ecto-5’-nucleotidase (CD73) in the brain – role in adenosine A2A receptor activation
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/07 - 2013/12 Interação funcional entre receptores nicotínicos e de adenosina pré-sinápticos no controlo da libertação de dopamina no estriado
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03 - 2013/10 Gene transfer approach for the study of the adenosine A2A receptors role in Machado Joseph Disease
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/01 - 2013/07 Role of adenosine A2A receptors in astrocytes - implications for glutamatergic activity
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/01 - 2013/03 Estudo da interação do sistema purinérgico, colinérgico e funções cognitivas na demência esporádica do tipo Alzheimer:os efeitos das antocianinas
Coorientador
Universidade Federal de Santa Maria, Brasil
2009/10 - 2013/02 Estratégias de neuroproteção em modelos animais da doença de Parkinson: avaliação bioquímica e comportamental
Coorientador
Universidade Federal de Santa Catarina, Brasil
2009/07 - 2012/12 Regulation of mitochondrial function in ischemia/reperfusion: looking for therapeutic strategies in fatty livers
Coorientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/07 - 2012/12 Presynaptic A2A adenosine receptors control CB1 cannabinoid receptor-mediated effects at the corticostriatal nerve terminals
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/01 - 2012/12 Adenosina na vida e na morte das células ganglionares da retina, estudo da modulação e potencial efeito protetor
Coorientador
Universidade de Coimbra, Portugal
2009/06 - 2012/11 Proteína prion celular (PrPC) altera a suscetibilidade ao etanol através da modulação do sistema dopaminérgico
Coorientador
Universidade Federal de Santa Catarina, Brasil
2009/01 - 2012/04 Purinergic control of neuroinflammation and neuroprotection afforded by the blockade of P2 receptors under excitotoxic conditions in the hippocampus
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/06 - 2011/12 Effect of purines in the developing hippocampus: consequences for the establishment of circuits related to learning and memory
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/02 - 2011/02 Estudo do sistema purinérgico glial: Modulação da MAP cinase e do transporte de adenosina em culturas de glia da retina e astrócitos cerebrais
Coorientador
Universidade Federal Fluminense, Brasil
2007/03 - 2010/08 A cafeína como estratégia de prevenção do declínio cognitivo em modelos animais
Coorientador
Universidade Federal de Santa Catarina, Brasil
2001/01 - 2010/07 Depression of synaptic transmission during hypoxia - mechanisms and relevance for neuroprotection
Coorientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2006/07 - 2009/11 Neuroprotection by adenosine receptors in aged rats – role of neuroinflammation
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2006/02 - 2009/05 Avaliação do sistema purinérgico de ratos jovens e adultos após indução de epilépsia e sua interacção com parâmetros comportamentais
Coorientador
Universidade Federal do Rio Grande do Sul, Brasil
2006/01 - 2009/02 Relation between metabolic alterations in the hippocampus and memory deficits induced by diabetes
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004/10 - 2008/09 Beneficial effects of caffeine consumption on diabetes-induced alterations in the hippocampus
Orientador
Universidade de Coimbra, Portugal
2005/01 - 2008/08 Efeito dos receptores A1 e A2A de adenosina sobre alterações comportamentais, bioquímicas e morfológicas induzidas pelo estresse crónico imprevisível em camundongos
Coorientador
Universidade Federal de Santa Catarina, Brasil
2005/01 - 2008/03 Ecto-nucleotidases e indicadores de injúria cerebral: correlações com epilépsia e convulsões
Coorientador
Universidade Fderal do Rio Grande do Sul, Brasil
2003/01 - 2008/01 Neuroprotection by adenosine A2A receptors: Functional and biochemical mechanisms
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003/01 - 2007/09 Role of ATP (P2) receptors in the control of neuronal function
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005/09 - 2006/11 Envolvimento do Sistema Purinérgico, Lactato e Glicose em Insultos do Sistema Nervoso Central
Orientador
Universidade Federal do Rio Grande do Sul Instituto de Biociências, Brasil
2002/01 - 2006/03 Interaction between purinergic and nicotinic receptors
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2000/01 - 2003/10 Adenosine receptors crosstalk in the rat hippocampus
Orientador de Luísa Maria Vaqueiro Lopes
Universidade de Lisboa Faculdade de Ciências, Portugal

Tutoria

Tópico Nome do aluno
2019/05 - 2021/05 post-doc: Spatiotemporal control of hippocampal synaptic plasticity by adenosine A2A receptors Francisco Manuel Queiroz Gonçalves
2017/02 - 2018/10 post-doc: Role of A2A receptors in the ergogenic effects of caffeine Aderbal Silva Aguiar Junior
2015/07 - 2018/07 post-doc: Hybrid ionotropic receptors: a new receptor concept Joana Medeiros Vieira Marques
2013/01 - 2018/01 post-doc: Role of adenosine receptors in the prefrontal cortex in an animal model of attention deficit and hyperactivity disorders Samira Cardoso Lopes Ferreira
2014/01 - 2017/07 post-doc: Adenosine A2A receptors controlling prefrontal cortical plasticity - impact on mood and memory Joana Isabel Estudante Batista Real
2014/01 - 2017/02 post-doc: Adenosine A2A receptors in the ventral brain circuits mediate behavioral inhibition promoting depressive-like conditions Nélio da Mota Gonçalves
2012/10 - 2017/02 post-doc: Adenosine A2A receptors in the dorsomedial striatum bolster behavioral inhibition promoting depressive-like mood disorders Paula Margarida Gomes Canas
2013/01 - 2017/01 post-doc: Tinkering with adenosine metabolism to manipulate adenosine neuromodulation and bolster neuroprotection in brain disorders João Pedro Oliveira da Silva Paulino Lopes
2012/11 - 2016/11 post-doc: Role of adenosine receptors in the pathophysiology of the amygdaloid complex: implications for fear conditioning and post-traumatic stress disorder Ana Patrícia Figueiredo Rocha Simões
2010/01 - 2016/04 post-doc: Neuromodulation by adenosine of synaptic plasticity Henrique Bernardo da Silva
2009/01 - 2015/08 post-doc: Interaction between adenosine A2A receptors and growth factors in the control of neurodegeneration and brain repair Catarina Alexandra Reis Vale Gomes
2013/02 - 2015/05 post-doc: Role of adenosine A2A receptors in the control of synaptic plasticity at striatal glutamatergic synapses in health and disease Daniel Rial
2012/07 - 2014/12 post-doc: Role of adenosine A2A receptors in different brain regions in the control of chronic stress neuropathology Carolina Melo de Sousa
2011/08 - 2013/05 post-doc: Presynaptic NMDA receptors - interaction with adenosine receptors Stefania Zappettini
2010/05 - 2013/04 post-doc: Role of ATP as danger signal and therapeutic potential of P2 receptors in brain disorders Daniela Pochmann
2009/07 - 2012/12 post-doc: Role of adenosine A2A receptors in glutamatergic neurons and in microglia in the control of synaptic plasticity and brain damage Ana Margarida Quaresma Fernandes Nunes
2008/10 - 2012/07 post-doc: Opposite control by caffeine and adenosine receptors of neuronal plasticity in the hippocampus and amygdala complex after stress Manuella Pinto Kaster
2011/03 - 2012/04 post-doc: Impacto do bloqueio genético ou farmacológico de receptores A2A para a adenosina num modelo de doença de Parkinson baseado na administração intra-nasal de uma toxina (MPTP) Rui Daniel Schroder Prediger
2007/04 - 2008/05 post-doc: Functional properties of co-expressed CB1 and adenosine A2A receptors in HEK293 cells Gabriele Ghisolfi
2003/01 - 2007/06 post-doc: Role of P2 receptors in the control of hippocampal and striatal function Attila Kofalvi
2003/07 - 2005/07 post-doc: Modificação de sistemas de modulação purinérgicos em modelos experimentais de epilepsia Lisiane de Oliveira Porciúncula
2004/01 - 2004/12 post-doc: Efeito da estimulação neurotóxica com cainato e LPS sobre o sistema modulatório da adenosina e o efeito neuroprotetor pelos receptores A2A Geanne Matos da Cunha
1998/09 - 1999/09 post-doc: Role of ATP in the control of neuromuscular transmission at the rat innervated hemidiaphragm Audrey Ivanenko Salgado
Distinções

Prémio

2016 João José Freitas Sarkis Award
Clube Brasileiro de Purinas, Brasil
2011 Award of Teaching Excellence
MIT-Portugal, Portugal
2004 Neurodegenerative Diseases’ Award
Sociedade Portuguesa de Neurociências, Portugal
2002 Pfizer Award nomination
Laboratórios Pfizer Ltda, Brasil
2002 Young Investigator Award
Biologie Servier, França
1997 Award of Pharmacology
UCB Pharma Produtos Farmacêuticos LDA, Portugal
1995 Stimulus to Investigation Award
Fundação Calouste Gulbenkian, Portugal
1994 ‘Boa Esperança’ Award nomination
Fundação para a Ciência e a Tecnologia, Portugal

Título

2019 Honorary member
Clube Brasileiro de Purinas, Brasil