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Rodrigo Antunes Cunha. Concluiu o(a) Doutoramento em Bioquímica em 1994/07 pelo(a) Universidade de Lisboa Faculdade de Ciências, Licenciatura em Bioquímica em 1989/06 pelo(a) Universidade de Lisboa Faculdade de Ciências e Licence em Clinical Research Associate em 1994/12 pelo(a) Rhône-Poulenc Rorer. É Professor Catedrático no(a) Universidade de Coimbra Faculdade de Medicina. Publicou 262 artigos em revistas especializadas. Possui 1 capítulo(s) de livros. Orientou 12 tese(s) de doutoramento e coorientou 25. Recebeu 9 prémio(s) e/ou homenagens. Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Neurociências. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: envelhecimento plasticidade; Alzheimer; memória; plasticidade sináptica; receptores; adenosina; .
Identification

Personal identification

Full name
Rodrigo Antunes Cunha

Citation names

  • Cunha, Rodrigo A.

Author identifiers

Ciência ID
CF1A-8BED-B840
ORCID iD
0000-0003-2550-6422
Researcher Id
E-7475-2015
Scopus Author Id
7102879525

Email addresses

  • rcunha@fmed.uc.pt (Professional)

Addresses

  • CNC-Centro de Neurociências e Biologia Celular, Edifício da Faculdade de Medicina, Piso 1, Polo I, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Professional)
  • FMUC, Instituto de Bioquímica, Unidade Central, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Proficiency (C2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Intermediate (B1)
Italian Beginner (A1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2008/12 - 2008/12
Concluded
Biomedicina (Especialização pós-licenciatura)
Major in Fisiologia do Envelhecimento
Universidade de Coimbra Faculdade de Medicina, Portugal
aprovado por unanimidade
1995/01 - 1996/09
Concluded
Neurosciences (Pós-doutoramento)
Major in Neuropharmacology
Karolinska Institutet, Sweden
1994/03 - 1994/12
Concluded
Clinical Research Associate (Licence)
Rhône-Poulenc Rorer, France
aprovado
1990/01 - 1994/07
Concluded
Bioquímica (Doutoramento)
Major in Farmacologia
Universidade de Lisboa Faculdade de Ciências, Portugal
"Origem e Função Neuromoduladora da Adenosina no Sistema Nervoso" (THESIS/DISSERTATION)
distinção e louvor
1984/10 - 1989/06
Concluded
Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Caracterização do catabolismo extracelular de nucleótidos de adenina na junção neuromuscular de rã" (THESIS/DISSERTATION)
17 / 20
Affiliation

Science

Category
Host institution
Employer
1995/03 - 1996/09 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
1991/01 - 1993/12 Research Trainee (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Gulbenkian de Ciência, Portugal
1989/09 - 1990/12 Research Trainee (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2019/09 - Current Full Professor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2004/03 - 2019/08 Associate Professor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2001/03 - 2004/03 Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
1996/10 - 2001/02 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal

Others

Category
Host institution
Employer
1994/04 - 1995/02 Clinical Research Associate Rhône-Poulenc Rorer, France
Rhône-Poulenc Rorer, France
Projects

Grant

Designation Funders
2018/01 - 2019/12 Manipulação dos receptores A2A da adenosina para controlar os sintomas do síndrome de Angelman Fundação Amélia de Mello
2014/03 - 2015/09 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing Fundação para a Ciência e a Tecnologia, I.P.
2012/04 - 2014/09 Role of accumbens and amygdala in the control of chronic stress neuropathology Fundação para a Ciência e a Tecnologia, I.P.
2012/05 - 2014/08 Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/09 Role of ATP and its P2Y1 receptors in neuroprotection Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/02 Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage Fundação para a Ciência e a Tecnologia, I.P.
2007/05 - 2010/04 Interaction between nicotine and caffeine in the striatum. Relevance for Parkinson´s disease Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2009/10 EFFECT OF PURINES IN THE DEVELOPING HIPPOCAMPUS: CONSEQUENCES FOR THE ESTABLISHMENT OF CIRCUITS RELATED TO LEARNING AND MEMORY Fundação para a Ciência e a Tecnologia, I.P.
2007/06 - 2009/08 Role of extracellular ATP and characterization of purinergic receptors in the resistance of Candida albicans to macrophage attack Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2008/01 Relation between metabolic alterations in the hippocampus and memory deficits induced by diabetes Fundação para a Ciência e a Tecnologia, I.P.
2005/10 - 2007/12 Modification by chronic caffeine consumption of adenosine neuromodulation in the hippocampus - possible relevance for learning and memory Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 Characterization of purinergic receptors in hippocampal mossy fibers - role in epilepsy Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 Control by adenosine of neuro-inflammation Fundação para a Ciência e a Tecnologia, I.P.
2005/01 - 2007/02 NEUROPROTECTION BY ADENOSINE RECEPTORS: COUPLING ENHANCED ADENOSINE FORMATION WITH A2A RECEPTOR BLOCKADE Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2019/12 - 2022/12 Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress
LCF/PR/HP17/52190001
Principal investigator
Universidade de Coimbra, Portugal
Caixabank SA
Ongoing
2020/01 - 2022/09 Adenosine A2A receptor antagonism affords integrated benefits for neurological symptoms of neurofibromatosis type I
W81XWH-18-1-0532NF170062
Principal investigator
Universidade de Coimbra, Portugal
Congressionally Directed Medical Research Programs
Ongoing
2018/05 - 2022/06 Strategies for healthy aging
CENTRO-01-0246-FEDER-000010
Universidade de Coimbra, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2020/01/01 - 2022/04/01 MIA-Portugal Multidisciplinary Institute of Ageing
Principal investigator
Universidade de Coimbra, Portugal
Ongoing
2018/07/01 - 2021/06/30 Recetores A2A da adenosina como desencadeadores de disfunção mnemónica na doença de Alzheimer: mecanismos e possibilidade terapêutica
PTDC/MED-NEU/31274/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2021/06 Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer’s disease: mechanisms and therapeutic propects
POCI-01-0145-FEDER-031274
Principal investigator
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05 - 2019/06 Role of astrocytes in the control of memory – focus on adenosine A2A receptors
PTDC/NEU-NMC/4154/2014
Fundação para a Ciência e a Tecnologia
2014/10 - 2018/03 Role des récepteurs de l'adénosine dans la stabilisation des synapses Agence nationale de la recherche
2016/03 - 2017/08 Adenosine A2A receptors controls non-motor (mood and cognitive) symptoms in Parkinson’s disease
CAPES-FCT 8543/2014-03
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
2013/09 - 2017/05 Role of adenosine A2A receptors in the control of synaptic plasticity in the prefrontal cortex – relevance for attention deficit and hyperactivity disorders
159302-1-2009-1-NL-ERA MUNDUS-EMJD
European Commission
2014/10 - 2016/06 ROLE OF ADENOSINE A2A RECEPTORS IN THE ACCUMBENS AND AMYGDALA IN THE CONTROL OF CHRONIC STRESS NEUROPATHOLOGY
NARSAD Independent Investigator Grant
Principal investigator
Universidade de Coimbra, Portugal
Brain and Behavior Research Foundation
Concluded
2014/03/01 - 2015/09/30 Ageing@Coimbra: Um Centro de Co-localização na Rede Europeia de Conhecimento e Inovação para o Envelhecimento Saudável e Ativo
EIT-KIC/IVE/0043/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/04/01 - 2014/09/30 Papel do accumbens e amigdala no controlo da neuropatologia causada por stress crónico
PTDC/SAU-NSC/122254/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/05/01 - 2014/08/31 Papel fisio-patológico da ecto-5`-nucleotidase - um novo alvo para neuroprotecção
PTDC/SAU-TOX/122005/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/03/18 - 2012/09/17 Papel do ATP e dos seus receptores P2Y1 na neuroprotecção
PTDC/SAU-FCF/100423/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Canas, Paula M.; Cunha, Rodrigo A.. "Subsynaptic Membrane Fractionation". In Receptor and Ion Channel Detection in the Brain, 31-38. Springer US, 2021.
    Published • 10.1007/978-1-0716-1522-5_3
  2. Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Adenosine Receptors in Alzheimer’s Disease". In The Adenosine Receptors, 259-280. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-90808-3_11
  3. Prediger, Rui Daniel; Matheus, Filipe Carvalho; de Oliveira, Paulo Alexandre; Rial, Daniel; Moretti, Morgana; de Souza, Ana Cristina Guerra; Aguiar, Aderbal Silva; Cunha, Rodrigo A.. "Adenosine A2A Receptor-Mediated Control of Non-Motor Functions in Parkinson’s Disease". In Current Topics in Neurotoxicity, 183-205. Springer International Publishing, 2015.
    Published • 10.1007/978-3-319-20273-0_10
  4. Prediger, Rui Daniel; Matheus, Filipe Carvalho; de Oliveira, Paulo Alexandre; Rial, Daniel; Moretti, Morgana; de Souza, Ana Cristina Guerra; Aguiar, Aderbal Silva; Cunha, Rodrigo A.. "Adenosine A2A Receptor-Mediated Control of Non-Motor Functions in Parkinson’s Disease". In Current Topics in Neurotoxicity, 183-205. Springer International Publishing, 2015.
    Published • 10.1007/978-3-319-20273-0_10
  5. Gomes, Catarina; George, Jimmy; Chen, Jiang-Fan; Cunha, Rodrigo A.. "Role of Adenosine A2A Receptors in the Control of Neuroinflammation—Relevance for Parkinson’s Disease". In Current Topics in Neurotoxicity, 81-99. Springer International Publishing, 2015.
    Published • 10.1007/978-3-319-20273-0_5
  6. Rial, Daniel; Lara, Diogo R.; Cunha, Rodrigo A.. "The Adenosine Neuromodulation System in Schizophrenia". edited by Mori, A., 395-449. 2014.
    10.1016/b978-0-12-801022-8.00016-7
  7. Cunha, R. A.. "Adenosine Neuromodulation and Neuroprotection". In Handbook of Neurochemistry and Molecular Neurobiology, 255-273. Springer US, 2008.
    Published • 10.1007/978-0-387-30382-6_11
  8. Cunha, Rodrigo A.; Chen, Jiang-Fan; Sitkovsky, Michail V.. "Opposite Modulation of Peripheral Inflammation and Neuroinflammation by Adenosine A2A Receptors". In Interaction Between Neurons and Glia in Aging and Disease, 53-79. Springer US, 2007.
    Published • 10.1007/978-0-387-70830-0_3
Edited book
  1. Malva, João; Cunha, Rodrigo; Oliveira, Catarina R.. Interaction Between Neurons and Glia in Aging and Disease. Springer US. 2007.
    Published • 10.1007/978-0-387-70830-0
Journal article
  1. Zhou, Xuzhao; He, Yan; Xu, Tao; Wu, Zhaofa; Guo, Wei; Xu, Xi; Liu, Yuntao; et al. "40 Hz light flickering promotes sleep through cortical adenosine signaling". Cell Research (2024): http://dx.doi.org/10.1038/s41422-023-00920-1.
    Accepted • 10.1038/s41422-023-00920-1
  2. Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al. "The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". Molecular Psychiatry (2024): http://dx.doi.org/10.1038/s41380-024-02412-z.
    Accepted • 10.1038/s41380-024-02412-z
  3. Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata; Ana Paula Tavares; et al. "The striatum drives the ergogenic effects of caffeine". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-023-09922-5.
    10.1007/s11302-023-09922-5
  4. Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors". Cellular and Molecular Life Sciences (2023): https://doi.org/10.1007/s00018-023-04983-6.
    10.1007/s00018-023-04983-6
  5. Simões, Ana P.; Portes, Marina A. M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride L.; et al. "Adenosine A2A receptors control generalization of contextual fear in rats". Translational Psychiatry 13 1 (2023): http://dx.doi.org/10.1038/s41398-023-02613-0.
    Published • 10.1038/s41398-023-02613-0
  6. Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice". Glia (2023): https://doi.org/10.1002/glia.24384.
    10.1002/glia.24384
  7. Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease". Biomolecules (2023): https://doi.org/10.3390/biom13081173.
    10.3390/biom13081173
  8. Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda; et al. "Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest". Frontiers in Behavioral Neuroscience 17 (2023): http://dx.doi.org/10.3389/fnbeh.2023.1176382.
    Published • 10.3389/fnbeh.2023.1176382
  9. Pedro Valada; Sonja Hinz; Christin Vielmuth; Cátia R. Lopes; Rodrigo A. Cunha; Christa E. Müller; João Pedro Lopes. "The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-022-09899-7.
    10.1007/s11302-022-09899-7
  10. Fernandes, Mara Yone D.; Lopes, João Pedro; Silva, Henrique B.; Andrade, Geanne M.; Cunha, Rodrigo A.; Tomé, Angelo R.. "Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices". Neuroscience Letters 808 (2023): 137292. http://dx.doi.org/10.1016/j.neulet.2023.137292.
    Published • 10.1016/j.neulet.2023.137292
  11. Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation". Biomolecules (2023): https://doi.org/10.3390/biom13040715.
    10.3390/biom13040715
  12. Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences 24 8 (2023): 6968. http://dx.doi.org/10.3390/ijms24086968.
    Published • 10.3390/ijms24086968
  13. Wang, Muran; Li, Peijun; Li, Zewen; da Silva, Beatriz S.; Zheng, Wu; Xiang, Zhenghua; He, Yan; et al. "Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37601-x.
    Published • 10.1038/s41467-023-37601-x
  14. Gonçalves, Francisco Q.; Valada, Pedro; Matos, Marco; Cunha, Rodrigo A.; Tomé, Angelo R.. "Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals". Purinergic Signalling (2023): http://dx.doi.org/10.1007/s11302-023-09937-y.
    Accepted • 10.1007/s11302-023-09937-y
  15. Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; et al. "Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress". ACS Chemical Neuroscience 14 7 (2023): 1299-1309. http://dx.doi.org/10.1021/acschemneuro.2c00810.
    Published • 10.1021/acschemneuro.2c00810
  16. Jiang-Fan Chen; Doo-Sup Choi; Rodrigo A. Cunha. "Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility". Neuropharmacology (2023): https://doi.org/10.1016/j.neuropharm.2023.109421.
    10.1016/j.neuropharm.2023.109421
  17. Cátia R. Lopes; Andreia Oliveira; Ingride Luzio Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas". Biomolecules (2023): https://www.mdpi.com/2218-273X/13/1/106.
    10.3390/biom13010106
  18. Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-Pierre; et al. "Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease". Molecular Neurobiology 60 3 (2022): 1659-1674. http://dx.doi.org/10.1007/s12035-022-03162-1.
    Accepted • 10.1007/s12035-022-03162-1
  19. Dewaeles, Edmone; Carvalho, Ke´vin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan; et al. "Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects". Journal of Clinical Investigation 132 22 (2022): http://dx.doi.org/10.1172/jci152924.
    Published • 10.1172/jci152924
  20. Bruno Gonçalves Pinheiro; Diandra Araújo Luz; Sabrina de Carvalho Cartágenes; Luanna de Melo Pereira Fernandes; Sarah Viana Farias; Natália Harumi Correa Kobayashi; Enéas Andrade Fontes-Júnior; et al. "The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine". Pharmaceuticals (2022): https://doi.org/10.3390/ph15111323.
    10.3390/ph15111323
  21. Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Rodrigo A. Cunha. "CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232112826.
    10.3390/ijms232112826
  22. Pedro Valada; Sofia Alçada-Morais; Rodrigo A. Cunha; João Pedro Lopes. "Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231810510.
    10.3390/ijms231810510
  23. Xu, Xinli; Beleza, Rui O.; Gonçalves, Francisco Q.; Valbuena, Sergio; Alçada-Morais, Sofia; Gonçalves, Nélio; Magalhães, Joana; et al. "Adenosine A2A receptors control synaptic remodeling in the adult brain". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18884-4.
    Published • 10.1038/s41598-022-18884-4
  24. Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho. "Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04492-y.
    10.1007/s00018-022-04492-y
  25. Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; et al. "Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription". Journal of Clinical Investigation 132 12 (2022): http://dx.doi.org/10.1172/jci149371.
    Published • 10.1172/jci149371
  26. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas. "Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes". Purinergic Signalling (2022): https://doi.org/10.1007/s11302-022-09864-4.
    10.1007/s11302-022-09864-4
  27. Carvalho da Silva, António M.; Lemos, Cristina; Silva, Henrique B.; Ferreira, Ildete L.; Tomé, Angelo R.; Rego, A. Cristina; Cunha, Rodrigo A.. "Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.835885.
    Published • 10.3389/fnagi.2022.835885
  28. IJzerman, Adriaan P.; Jacobson, Kenneth A.; Müller, Christa E.; Cronstein, Bruce N.; Cunha, Rodrigo A.. "International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update". Pharmacological Reviews 74 2 (2022): 340-372. http://dx.doi.org/10.1124/pharmrev.121.000445.
    Published • 10.1124/pharmrev.121.000445
  29. Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré. "Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome". Molecules (2022): https://doi.org/10.3390/molecules27051489.
    10.3390/molecules27051489
  30. Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure". Journal of Neurochemistry (2022): https://doi.org/10.1111/jnc.15575.
    10.1111/jnc.15575
  31. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho. "Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-021-02538-z.
    10.1007/s12035-021-02538-z
  32. Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al. "Convergence of adenosine and GABA signaling for synapse stabilization during development". Science 374 6568 (2021): http://dx.doi.org/10.1126/science.abk2055.
    10.1126/science.abk2055
  33. Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, Marco; et al. "Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction". Neurobiology of Disease 157 (2021): 105441. http://dx.doi.org/10.1016/j.nbd.2021.105441.
    Published • 10.1016/j.nbd.2021.105441
  34. Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al. "l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory". The FASEB Journal 35 8 (2021): https://doi.org/10.1096/fj.202100336R.
    10.1096/fj.202100336R
  35. Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A.. "Adenosine A2A Receptors as Biomarkers of Brain Diseases". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.702581.
    10.3389/fnins.2021.702581
  36. Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto; Gonçalves, Teresa; Rodrigues, Lisa. "Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps Escape". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.678568.
    10.3389/fcimb.2021.678568
  37. Aguiar, Aderbal S.; Speck, Ana Elisa; Canas, Paula M.; Cunha, Rodrigo A.. "Deletion of CD73 increases exercise power in mice". Purinergic Signalling 17 3 (2021): 393-397. http://dx.doi.org/10.1007/s11302-021-09797-4.
    Published • 10.1007/s11302-021-09797-4
  38. Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães, Joana; et al. "Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation". Cerebral Cortex 31 12 (2021): 5652-5663. http://dx.doi.org/10.1093/cercor/bhab188.
    Published • 10.1093/cercor/bhab188
  39. Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A. A.; Porciúncula, Lisiane O.; et al. "Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-89964-0.
    10.1038/s41598-021-89964-0
  40. Lopes, Cátia R.; Cunha, Rodrigo A.; Agostinho, Paula. "Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.666710.
    10.3389/fnins.2021.666710
  41. Lopes, Cátia R.; Lourenço, Vanessa S.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula M.. "Use of knockout mice to explore CNS effects of adenosine". Biochemical Pharmacology 187 (2021): 114367. http://dx.doi.org/10.1016/j.bcp.2020.114367.
    Published • 10.1016/j.bcp.2020.114367
  42. Figueiredo, Amanda Braga; Oliveira e Castro, Renata Alves; Nogueira-Paiva, Nívia Carolina; Moreira, Filipa; Gonçalves, Francisco Queiroz; Soares, Rodrigo Pedro; Castro-Borges, William; et al. "Clustering of adenosine A2Breceptors with ectonucleotidases in caveolin-rich lipid rafts underlies immunomodulation byLeishmania amazonensis". The FASEB Journal 35 5 (2021): http://dx.doi.org/10.1096/fj.202002396rr.
    Published • 10.1096/fj.202002396rr
  43. Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Ângelo R.; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D.. "Exercise decreases aberrant corticostriatal plasticity in an animal model of l-DOPA-induced dyskinesia". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320 4 (2021): R541-R546. http://dx.doi.org/10.1152/ajpregu.00295.2020.
    Published • 10.1152/ajpregu.00295.2020
  44. Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A.. "Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress". Frontiers in Cellular Neuroscience 15 (2021): http://dx.doi.org/10.3389/fncel.2021.639322.
    Published • 10.3389/fncel.2021.639322
  45. Cristiane do Socorro Ferraz Maia; Letícia Yoshitome Queiroz; Igor Gonçalves Oliveira; Carla Cristiane Soares Silva; Rodrigo A. Cunha; Deiweson Souza-Monteiro; Maria Karolina Martins Ferreira; et al. "Binge-Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood". Alcoholism: Clinical and Experimental Research 45 1 (2021): 56-63. https://doi.org/10.1111/acer.14501.
    10.1111/acer.14501
  46. Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02275-9.
    10.1007/s12035-020-02275-9
  47. Cunha, Rodrigo. "Control of glutamate release by complexes of adenosine and cannabinoid receptors". BMC Biology (2020): http://dx.doi.org/10.1186/s12915-020-0739-0.
    10.1186/s12915-020-0739-0
  48. Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome". Neurobiology of Disease 146 (2020): 105137-105137. https://doi.org/10.1016/j.nbd.2020.105137.
    10.1016/j.nbd.2020.105137
  49. Agostinho, Paula; Madeira, Daniela; Dias, Liliana; Simões, Ana Patrícia; Cunha, Rodrigo A.; Canas, Paula M.. "Purinergic signaling orchestrating neuron-glia communication". Pharmacological Research 162 (2020): 105253. http://dx.doi.org/10.1016/j.phrs.2020.105253.
    Published • 10.1016/j.phrs.2020.105253
  50. de Santana Souza, Lisiane; de Siqueira, Priscila Albuquerque; Fernandes, Arlete; Silva Martins, Robertta; Cussa Kubrusly, Regina Célia; Paes-de-Carvalho, Roberto; Cunha, Rodrigo A.; dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo. "Role of Neuropeptide S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder". Neuroscience 448 (2020): 140-148. http://dx.doi.org/10.1016/j.neuroscience.2020.09.030.
    Published • 10.1016/j.neuroscience.2020.09.030
  51. Nehlig, Astrid; Cunha, Rodrigo. "The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation". Nutrients 12 10 (2020): 3141. http://dx.doi.org/10.3390/nu12103141.
    Published • 10.3390/nu12103141
  52. Matilde S. Rodrigues; Cláudia Ferreira; Cândida Dias; Anna Pliássova; Lisiane Souza; Ana Ledo; João Laranjinha; Rodrigo A. Cunha; Attila Köfalvi. "An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease". European Journal of Neuroscience (2020): https://doi.org/10.1111/ejn.14944.
    10.1111/ejn.14944
  53. Mack, Josiel Mileno; de Menezes Moura, Tainara; Bobinski, Franciane; Martins, Daniel Fernandes; Cunha, Rodrigo A.; Walz, Roger; Fernandes, Pedro Augusto; et al. "Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice". NeuroToxicology 80 (2020): 144-154. http://dx.doi.org/10.1016/j.neuro.2020.07.008.
    10.1016/j.neuro.2020.07.008
  54. Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo A.; Andrade, Geanne M.. "ATP Signaling Controlling Dyskinesia Through P2X7 Receptors". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.00111.
    Published • 10.3389/fnmol.2020.00111
  55. Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al. "Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes". Brain Research Bulletin 161 (2020): 106-115. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004.
    Published • 10.1016/j.brainresbull.2020.05.004
  56. França, Angela Patricia; Schamne, Marissa Giovanna; de Souza, Bruna Soares; da Luz Scheffer, Débora; Bernardelli, Angelica Karina; Corrêa, Thiago; de Souza Izídio, Geison; et al. "Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder". Molecular Neurobiology 57 9 (2020): 3902-3919. http://dx.doi.org/10.1007/s12035-020-02002-4.
    Published • 10.1007/s12035-020-02002-4
  57. Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Angelo R. Tomé; Cunha, Rodrigo A.; Ana M. Sebastião; Boison, Detlev. "Role of Adenosine in Epilepsy and Seizures". Journal of Caffeine and Adenosine Research 10 2 (2020): 45-60. http://dx.doi.org/10.1089/caff.2019.0022.
    10.1089/caff.2019.0022
  58. Pliássova, Anna; Henriques, Margarida; Silva, Henrique B.; Agostinho, Paula; Cunha, Rodrigo A.; Ferreira, Samira G.. "Control of NMDA Receptor-Mediated Currents by Adenosine A1 and A2A Receptors Within the Basolateral Amygdala". Journal of Caffeine and Adenosine Research 10 2 (2020): 61-70. http://dx.doi.org/10.1089/caff.2019.0024.
    Published • 10.1089/caff.2019.0024
  59. Cunha, Rodrigo. "The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease". Purinergic Signalling (2020): http://dx.doi.org/10.1007/s11302-020-09694-2.
    10.1007/s11302-020-09694-2
  60. Cunha, Rodrigo. "Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: Brain region and sex specificities". European Journal of Neuroscience (2020): http://dx.doi.org/10.1111/ejn.14561.
    10.1111/ejn.14561
  61. Cunha, Rodrigo. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine". Neurobiology of Disease (2019): http://dx.doi.org/10.1016/j.nbd.2019.104570.
    10.1016/j.nbd.2019.104570
  62. Rodrigo A Cunha. "Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration". Brain (2019): https://doi.org/10.1093/brain/awz335.
    10.1093/brain/awz335
  63. Cunha, Rodrigo. "Purinergic signalling and brain development". Seminars in Cell & Developmental Biology (2019): http://dx.doi.org/10.1016/j.semcdb.2018.12.001.
    10.1016/j.semcdb.2018.12.001
  64. Sara L. Reis; Henrique B. Silva; Margarida Almeida; Rodrigo A. Cunha; Ana P. Simões; Paula M. Canas. "Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14816.
    10.1111/jnc.14816
  65. Cunha, Rodrigo. "Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A 2A receptor over-activation in a rat model of Parkinson's disease". British Journal of Pharmacology (2019): http://dx.doi.org/10.1111/bph.14771.
    10.1111/bph.14771
  66. Cunha, Rodrigo. "Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve". Molecules (2019): http://dx.doi.org/10.3390/molecules24162863.
    10.3390/molecules24162863
  67. João P. Lopes; Anna Pliássova; Rodrigo A. Cunha. "The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors". Biochemical Pharmacology 166 (2019): 313-321. https://doi.org/10.1016/j.bcp.2019.06.008.
    10.1016/j.bcp.2019.06.008
  68. Cunha, Rodrigo. "Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit and hyperactivity disorder". European Journal of Neuroscience (2019): http://dx.doi.org/10.1111/ejn.14348.
    10.1111/ejn.14348
  69. João Pedro Lopes; Rodrigo A. Cunha. "What is the extracellular calcium concentration within brain synapses?". Journal of Neurochemistry (2019): https://doi.org/10.1111/jnc.14696.
    10.1111/jnc.14696
  70. Cunha, Rodrigo. "Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors". Molecular Neurobiology (2019): http://dx.doi.org/10.1007/s12035-018-1296-1.
    10.1007/s12035-018-1296-1
  71. Rodrigo A. Cunha. "Signaling by adenosine receptors—Homeostatic or allostatic control?". PLOS Biology 17 4 (2019): e3000213-e3000213. https://doi.org/10.1371/journal.pbio.3000213.
    10.1371/journal.pbio.3000213
  72. Cunha, Rodrigo. "Treadmill Exercise Attenuates l-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice". Molecular Neurobiology (2019): http://dx.doi.org/10.1007/s12035-018-1278-3.
    10.1007/s12035-018-1278-3
  73. Xavier Morató; Francisco Q. Gonçalves; João P. Lopes; Olga Jauregui; Concepció Soler; Víctor Fernández-Dueñas; Rodrigo A. Cunha; Francisco Ciruela. "Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice". Journal of Neurochemistry 148 6 (2019): 796-809. https://doi.org/10.1111/jnc.14653.
    10.1111/jnc.14653
  74. Cunha, Rodrigo. "Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus". Frontiers in Neuroscience (2019): http://dx.doi.org/10.3389/fnins.2018.01015.
    10.3389/fnins.2018.01015
  75. Cunha, Rodrigo. "Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats". Glia (2019): http://dx.doi.org/10.1002/glia.23476.
    10.1002/glia.23476
  76. Cunha, Rodrigo. "G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum". Neural Regeneration Research (2019): http://dx.doi.org/10.4103/1673-5374.259610.
    10.4103/1673-5374.259610
  77. Cunha, Rodrigo. "Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making". Frontiers in Molecular Neuroscience (2018): http://dx.doi.org/10.3389/fnmol.2018.00475.
    10.3389/fnmol.2018.00475
  78. Aderbal S. Aguiar, Jr; Ana Elisa Speck; Inês M. Amaral; Paula M. Canas; Rodrigo A. Cunha. "The exercise sex gap and the impact of the estrous cycle on exercise performance in mice". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-29050-0.
    10.1038/s41598-018-29050-0
  79. Cunha, Rodrigo. "Promises of Caffeine in Attention-Deficit/Hyperactivity Disorder: From Animal Models to Clinical Practice". Journal of Caffeine and Adenosine Research (2018): http://dx.doi.org/10.1089/caff.2018.0016.
    10.1089/caff.2018.0016
  80. Cunha, Rodrigo. "Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions". eneuro (2018): http://dx.doi.org/10.1523/eneuro.0385-18.2018.
    10.1523/eneuro.0385-18.2018
  81. Cunha, Rodrigo. "Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation". Human Molecular Genetics (2018): http://dx.doi.org/10.1093/hmg/ddy264.
    10.1093/hmg/ddy264
  82. Cunha, Rodrigo. "Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats". Frontiers in Neuroscience (2018): http://dx.doi.org/10.3389/fnins.2018.00653.
    10.3389/fnins.2018.00653
  83. António C. Silva; Cristina Lemos; Francisco Q. Gonçalves; Anna V. Pliássova; Nuno J. Machado; Henrique B. Silva; Paula M. Canas; et al. "Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease". Neurobiology of Disease 117 (2018): 72-81. https://doi.org/10.1016/j.nbd.2018.05.024.
    10.1016/j.nbd.2018.05.024
  84. Cunha, Rodrigo. "Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats". Behavioural Brain Research (2018): http://dx.doi.org/10.1016/j.bbr.2018.05.007.
    10.1016/j.bbr.2018.05.007
  85. Cunha, Rodrigo. "Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors". Molecular Psychiatry (2018): http://dx.doi.org/10.1038/s41380-018-0110-9.
    10.1038/s41380-018-0110-9
  86. Cunha, Rodrigo. "Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex". European Journal of Neuroscience (2018): http://dx.doi.org/10.1111/ejn.13912.
    10.1111/ejn.13912
  87. Cunha, Rodrigo. "Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex". Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2018.00133.
    10.3389/fphar.2018.00133
  88. Cunha, Rodrigo. "Chronic coffee consumption and respiratory disease: A systematic review". The Clinical Respiratory Journal (2018): http://dx.doi.org/10.1111/crj.12662.
    10.1111/crj.12662
  89. Cunha, Rodrigo. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell Death & Disease (2018): http://dx.doi.org/10.1038/s41419-018-0351-1.
    10.1038/s41419-018-0351-1
  90. Cunha, Rodrigo. "Elevated Pressure Changes the Purinergic System of Microglial Cells". Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2018.00016.
    10.3389/fphar.2018.00016
  91. Cunha, Rodrigo. "Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex". Frontiers in Pharmacology (2018): http://dx.doi.org/10.3389/fphar.2017.00899.
    10.3389/fphar.2017.00899
  92. Cunha, Rodrigo. "Distinct sensitivity to caffeine-induced insomnia related to age". Journal of Psychopharmacology (2018): http://dx.doi.org/10.1177/0269881117722997.
    10.1177/0269881117722997
  93. Cunha, Rodrigo. "The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo". Scientific Reports (2017): http://dx.doi.org/10.1038/s41598-017-10147-x.
    10.1038/s41598-017-10147-x
  94. Cunha, Rodrigo. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage". Cell Death & Disease (2017): http://dx.doi.org/10.1038/cddis.2017.451.
    10.1038/cddis.2017.451
  95. Cunha, Rodrigo. "Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer’s Disease". Journal of Alzheimer's Disease (2017): http://doi.org/10.3233/JAD-170356.
    10.3233/JAD-170356
  96. Cunha, Rodrigo. "Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential". Journal of Controlled Release (2017): http://dx.doi.org/10.1016/j.jconrel.2017.07.007.
    10.1016/j.jconrel.2017.07.007
  97. Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro. "Adenosine A 2A receptors are up-regulated and control the activation of human alveolar macrophages". Pulmonary Pharmacology & Therapeutics 45 (2017): 90-94. https://doi.org/10.1016/j.pupt.2017.04.009.
    10.1016/j.pupt.2017.04.009
  98. L Caetano; H Pinheiro; P Patrício; A Mateus-Pinheiro; N D Alves; B Coimbra; F I Baptista; et al. "Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety". Molecular Psychiatry 22 7 (2017): 1035-1043. https://doi.org/10.1038/mp.2016.173.
    10.1038/mp.2016.173
  99. Cunha, Rodrigo. "Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization". Journal of Visualized Experiments (2017): http://dx.doi.org/10.3791/55661.
    10.3791/55661
  100. Santos VV; Stark R; Rial D; Silva HB; Bayliss JA; Lemus MB; Davies JS; et al. "Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid beta (Aß1-40) administration in mice.". (2017): http://europepmc.org/abstract/med/28380673.
    10.1111/jne.12476
  101. Machado NJ; Simões AP; Silva HB; Ardais AP; Kaster MP; Garção P; Rodrigues DI; et al. "Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.". (2017): http://europepmc.org/abstract/med/26860412.
    10.1007/s12035-016-9774-9
  102. Gonçalves N; Simões AT; Prediger RD; Hirai H; Cunha RA; Pereira de Almeida L. "Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.". (2017): http://europepmc.org/abstract/med/28032667.
    10.1002/ana.24867
  103. Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al. "Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.". (2017): http://europepmc.org/abstract/med/27762079.
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  104. Rial D; Morató X; Real JI; Gonçalves FQ; Stagljar I; Pereira FC; Fernández-Dueñas V; Cunha RA; Ciruela F. "Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.". (2017): http://europepmc.org/abstract/med/28007645.
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  105. Ferreira DG; Batalha VL; Vicente Miranda H; Coelho JE; Gomes R; Gonçalves FQ; Real JI; et al. "Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity.". (2017): http://europepmc.org/abstract/med/26534909.
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  106. Rodrigo A. Cunha. "How does adenosine control neuronal dysfunction and neurodegeneration?". Journal of Neurochemistry (2016): http://dx.doi.org/10.1111/jnc.13724.
    10.1111/jnc.13724
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  278. Cunha, R.A.; Almeida, T.; Ribeiro, J.A.. "Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus". Journal of Biological Chemistry 275 48 (2000): 37572-37581. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535956&partnerID=MN8TOARS.
    10.1074/jbc.M003011200
  279. Pereira, M.F.; Hernández, M.D.; Pintor, J.; Miras-Portugal, M.T.; Cunha, R.A.; Ribeiro, J.A.. "Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals". Brain Research 879 1-2 (2000): 50-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342472159&partnerID=MN8TOARS.
    10.1016/S0006-8993(00)02726-8
  280. Cunha, R.A.; Cyrne, L.; Castanho, M.; Freire, A.P.. "Meeting Report - Biochemical Education at the University Level, Lisbon, Portugal, October 30-31, 1999". Biochemistry and Molecular Biology Education 28 4 (2000): 234-237. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033744526&partnerID=MN8TOARS.
    10.1016/S1470-8175(00)00008-4
  281. Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R.. "Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells". Experimental Eye Research 70 5 (2000): 577-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS.
    10.1006/exer.1999.0815
  282. Salgado, A.I.; Cunha, R.A.; Ribeiro, J.A.. "Facilitation by P2 receptor activation of acetylcholine release from rat motor nerve terminals: Interaction with presynaptic nicotinic receptors". Brain Research 877 2 (2000): 245-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034703241&partnerID=MN8TOARS.
    10.1016/S0006-8993(00)02679-2
  283. Pereira, M.F.; Cunha, R.A.; Ribeiro, J.A.. "Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats". Neurochemistry International 36 7 (2000): 563-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034214262&partnerID=MN8TOARS.
    10.1016/S0197-0186(99)00164-3
  284. Cunha, R.A.; Ribeiro, J.A.. "Adenosine A(2A) receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation". Neuroscience Letters 289 2 (2000): 127-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033624133&partnerID=MN8TOARS.
    10.1016/S0304-3940(00)01295-7
  285. A. Cunha, R.; Malva, J.O.; Ribeiro, J.A.. "Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release". FEBS Letters 469 2-3 (2000): 159-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034629239&partnerID=MN8TOARS.
    10.1016/S0014-5793(00)01272-2
  286. Cunha, R.A.; Ribeiro, J.A.. "Purinergic modulation of [3H]GABA release from rat hippocampal nerve terminals". Neuropharmacology 39 7 (2000): 1156-1167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034064253&partnerID=MN8TOARS.
    10.1016/S0028-3908(99)00237-3
  287. Cunha, R.A.; Brendel, P.; Zimmermann, H.; Ribeiro, J.A.. "Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus". Journal of Neurochemistry 74 1 (2000): 334-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033970847&partnerID=MN8TOARS.
    10.1046/j.1471-4159.2000.0740334.x
  288. Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R.. "Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress". Neurochemistry International 36 3 (2000): 255-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS.
    10.1016/S0197-0186(99)00113-8
  289. Benes, J.; Parada, A.; Figueiredo, A.A.; Alves, P.C.; Freitas, A.P.; Learmonth, D.A.; Cunha, R.A.; Garrett, J.; Soares-Da-Silva, P.. "Anticonvulsant and sodium channel-blocking properties of novel 10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives". Journal of Medicinal Chemistry 42 14 (1999): 2582-2587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566070&partnerID=MN8TOARS.
    10.1021/jm980627g
  290. Cunha, R.A.; Malva, J.O.; Ribeiro, J.A.. "Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus". Molecular Pharmacology 56 2 (1999): 429-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032793961&partnerID=MN8TOARS.
  291. Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A(2A) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 359 4 (1999): 295-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032947295&partnerID=MN8TOARS.
    10.1007/PL00005355
  292. Cunha, R.A.; Ribeiro, J.A.. "Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes". European Journal of Neuroscience 11 6 (1999): 2171-2174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033047188&partnerID=MN8TOARS.
    10.1046/j.1460-9568.1999.00661.x
  293. Almeida, T.; Cunha, R.A.; Ribeiro, J.A.. "Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus". Brain Research 826 1 (1999): 104-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033599818&partnerID=MN8TOARS.
    10.1016/S0006-8993(99)01267-6
  294. Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A1 receptor responses". European Journal of Pharmacology 383 3 (1999): 395-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779092&partnerID=MN8TOARS.
    10.1016/S0014-2999(99)00659-7
  295. Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "Cross talk between A1 and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats". Journal of Neurophysiology 82 6 (1999): 3196-3203. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033390941&partnerID=MN8TOARS.
  296. Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A.. "Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A(2A) receptors in the limbic cortex, but not striatum, of aged rats". Journal of Neurochemistry 73 4 (1999): 1733-1738. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032863555&partnerID=MN8TOARS.
    10.1046/j.1471-4159.1999.731733.x
  297. Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A.. "Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases". Progress in Brain Research 120 (1999): 183-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS.
  298. Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors". Journal of Neuroscience 18 6 (1998): 1987-1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032521330&partnerID=MN8TOARS.
  299. Cunha, R.A.; Foster, T.C.; Norris, C.M.; Verkhratsky, A.; Toescu, E.C.. "On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology (multiple letters)". Trends in Neurosciences 21 7 (1998): 286-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798434&partnerID=MN8TOARS.
  300. Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "ZM241385 is an antagonist of the facilitatory responses produced by the A(2A) adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus". British Journal of Pharmacology 122 7 (1997): 1279-1284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030734490&partnerID=MN8TOARS.
  301. Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A.. "Inhibition of [3H]¿-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes". European Journal of Pharmacology 323 2-3 (1997): 167-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030610655&partnerID=MN8TOARS.
    10.1016/S0014-2999(97)00043-5
  302. Gonçalves, M.L.; Cunha, R.A.; Ribeiro, J.A.. "Adenosine A(2A) receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes". Neuroscience Letters 238 1-2 (1997): 73-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031283080&partnerID=MN8TOARS.
    10.1016/S0304-3940(97)00803-3
  303. Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sa, P.; Sebastiao, A.M.. "Purinergic regulation of acetylcholine release". Progress in Brain Research 109 (1996): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030474316&partnerID=MN8TOARS.
  304. Cunha, R.A.; Johansson, B.; Constantino, M.D.; Sebastião, A.M.; Fredholm, B.B.. "Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 353 3 (1996): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670460&partnerID=MN8TOARS.
  305. Cunha, R.A.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices". Journal of Neurochemistry 67 5 (1996): 2180-2187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029819083&partnerID=MN8TOARS.
  306. Ribeiro, J.A.; De Mendonça, A.; Correia-de-Sá, P.; Cunha, R.A.; Sebastião, A.M.. "Purinoceptors and synaptic plasticity". Drug Development Research 39 3-4 (1996): 353-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030435849&partnerID=MN8TOARS.
  307. Cunha, R.A.; Correia-de-Sá, P.; Sebastião, A.M.; Ribeiro, J.A.. "Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides". British Journal of Pharmacology 119 2 (1996): 253-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029844019&partnerID=MN8TOARS.
  308. Cunha, R.A.; Johansson, B.; Fredholm, B.B.; Alexandre Ribeiro, J.; Sebastião, A.M.. "Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus". Neuroscience Letters 196 1-2 (1995): 41-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028984662&partnerID=MN8TOARS.
  309. Cunha, R.A.; Constantino, M.D.; Sebastiao, A.M.; Ribeiro, J.A.. "Modification of A1 and A(2a) adenosine receptor binding in aged striatum, hippocampus and cortex of the rat". NeuroReport 6 11 (1995): 1583-1588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028983106&partnerID=MN8TOARS.
  310. Malva, J.O.; Ambrósio, A.F.; Cunha, R.A.; Ribeiro, J.A.; Carvalho, A.P.; Carvalho, C.M.. "A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion". Neuroscience Letters 185 2 (1995): 83-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912732&partnerID=MN8TOARS.
    10.1016/0304-3940(94)11230-G
  311. Cunha, R.A.; Johansson, B.; van der Ploeg, I.; Sebastião, A.M.; Alexandre Ribeiro, J.; Fredholm, B.B.. "Evidence for functionally important adenosine A2a receptors in the rat hippocampus". Brain Research 649 1-2 (1994): 208-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028342730&partnerID=MN8TOARS.
  312. Cunha, R.A.; Milusheva, E.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M.. "Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus". Journal of Neurochemistry 63 1 (1994): 207-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028241057&partnerID=MN8TOARS.
  313. Cunha, R.A.; Ribeiro, J.A.; Sebastiao, A.M.. "Purinergic modulation of the evoked release of [3H]Acetylcholine from the hippocampus and cerebral cortex of the rat: Role of the ectonucleotidases". European Journal of Neuroscience 6 1 (1994): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028031731&partnerID=MN8TOARS.
    10.1111/j.1460-9568.1994.tb00245.x
  314. Cunha, R.A.; Sebastiao, A.M.. "Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog". Pflugers Archiv European Journal of Physiology 424 5-6 (1993): 503-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027250345&partnerID=MN8TOARS.
  315. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat". Journal of Neurochemistry 59 2 (1992): 657-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026660013&partnerID=MN8TOARS.
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  316. Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A.. "Relative contribution of nerve endings to the release of adenine nucleotides in the innervated frog sartorius muscle". Nucleosides and Nucleotides 10 5 (1991): 1189-1190. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026070005&partnerID=MN8TOARS.
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    10.1016/0014-2999(90)91979-L
  319. Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A.. "Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography". Chromatographia 28 11-12 (1989): 610-612. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001249211&partnerID=MN8TOARS.
    10.1007/BF02260687

Other

Other output
  1. Neuronal adenosine A2A receptors signal ergogenic effects of caffeine. 2020. Aderbal S Aguiar, Jr; Ana Elisa Speck; Paula M. Canas; Rodrigo A. Cunha. https://doi.org/10.1101/2020.04.02.021923.
    10.1101/2020.04.02.021923
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/07/01 - Current Avaliação do efeito neuroprotetor do corante Brilliant Blue G sobre camundongos submetidos ao modelo animal de Alzheimer induzido por estreptozotocina
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2022/02/01 - Current O papel dos recetores purinérgicos do tipo P2X7 na deposição de proteínas aberrantes e desregulação de vias autofágicas no parkinsonismo experimental
Co-supervisor
Faculdade de Medicina da Universidade Federal do Ceara, Brazil
2022/01/01 - Current Role of adenosine A2A receptors controlling synaptic senescence in ageing and Alzheimer´s disease
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/09 - 2023/12 Papel dos recetores de adenosina A2A astrocíticos no ontrolo da aquaporina 4 sob condições de stress crónico
Co-supervisor
Programa de Doutoramento em Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/09/01 - 2022/09/01 Crosstalk entre recetores de adenosina A2A e conexina43 na doença de Alzheimer
Co-supervisor
Universidade de Coimbra, Portugal
2021/05 - 2022/09 Receptores CB1 e CB2 modulam o transporte de GABA em retinas embrionárias de galinha expostas à cafeína
Co-supervisor
Universidade Federal Fluminense, Brazil
2016/01/01 - 2020/12/31 Pathophysiological role of adenosinergic modulation within the basolateral complex of the amygdala
Supervisor
Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas (PhD)
Universidade de Coimbra, Portugal
2016/01/01 - 2019/12/31 The Role of Adenosine A2A Receptor in the Migration of Cortical Principal Neurons
Co-supervisor
Universidade de Coimbra, Portugal
2016/01 - 2019/01 The role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons
Co-supervisor
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/02 - 2018/10 O exercício físico reduz as discinesias induzidas por L-DOPA: investigação da neuroproteção e das modificações na metaplasticidade estriatal
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2015/01 - 2018/06 Caffeine, adenosine and acetylcholine and neuronal function in the cortex
Co-supervisor
Vrije Universiteit Amsterdam, Netherlands
2015/01 - 2018/05 Physio-patological role of ecto-5’-nucleotidase – a new target for neuroprotection
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/03 - 2018/01 Adenosine receptors in inflammatory lung diseases
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/01 - 2017/04 Neurobiology of the Circadian Clock: Metabolism Control and Implications for Alzheimer´s disease
Co-supervisor
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014/01 - 2017/04 Role of the adenosinergic system in animal models of chronic stress and depression
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/09 - 2016/12 Avaliação do efeito neuroprotetor da guanosina em ratos submetidos a trauma crânio encefálico: envolvimento do sistema glutamatérgico e adenosinérgico
Co-supervisor
Universidade Federal de Santa Maria, Brazil
2013/07 - 2016/07 Metabolic modifications associated with memory deficits
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/06 - 2016/03 Recrutamento do receptor de adenosina A2B e ativação da via de AMPc-PI3K-ERK1/2 inibem a resposta de células dendríticas infectadas por Leishmania amazonensis
Co-supervisor
Universidade Federal de Ouro Preto, Brazil
2013/03 - 2016/01 Purines control neuron-glia interaction during neuroinflammation
Supervisor
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/01 - 2016/01 Candida-host interaction: role of purines and adenosine A2A receptors
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/06 - 2015/09 Estudo do efeito neuroprotetor da berberina sobre o dano neuronal, comportamento motor e memória de ratos com degeneração nidro-estriatal por 6-OHDA
Co-supervisor
Faculdade de Medicina da Universidade Federal do Ceara, Brazil
2012/03 - 2015/07 Dissociando anedonia de outros sintomas da depressão na doença de Parkinson em um modelo experimental em ratos : papel do estriado dorsolateral e do córtex pré-frontal
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2012/01 - 2015/03 Efeito neuroprotetor do antagonismo dos receptores P2X7 no parkinsonismo experimental induzido por 6-OHDA
Co-supervisor
Faculdade de Medicina da Universidade Federal do Ceara, Brazil
2011/02 - 2014/12 Pathophysiology of hippocampal CA3 neurons in the APP/PS1 mouse model of Alzheimer's disease
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/01 - 2014/10 Characterization of ecto-5’-nucleotidase (CD73) in the brain – role in adenosine A2A receptor activation
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/07 - 2013/12 Interação funcional entre receptores nicotínicos e de adenosina pré-sinápticos no controlo da libertação de dopamina no estriado
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/03 - 2013/10 Gene transfer approach for the study of the adenosine A2A receptors role in Machado Joseph Disease
Co-supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/01 - 2013/07 Role of adenosine A2A receptors in astrocytes - implications for glutamatergic activity
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/01 - 2013/03 Estudo da interação do sistema purinérgico, colinérgico e funções cognitivas na demência esporádica do tipo Alzheimer:os efeitos das antocianinas
Co-supervisor
Universidade Federal de Santa Maria, Brazil
2009/10 - 2013/02 Estratégias de neuroproteção em modelos animais da doença de Parkinson: avaliação bioquímica e comportamental
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2009/07 - 2012/12 Regulation of mitochondrial function in ischemia/reperfusion: looking for therapeutic strategies in fatty livers
Co-supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/07 - 2012/12 Presynaptic A2A adenosine receptors control CB1 cannabinoid receptor-mediated effects at the corticostriatal nerve terminals
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/01 - 2012/12 Adenosina na vida e na morte das células ganglionares da retina, estudo da modulação e potencial efeito protetor
Co-supervisor
Universidade de Coimbra, Portugal
2009/06 - 2012/11 Proteína prion celular (PrPC) altera a suscetibilidade ao etanol através da modulação do sistema dopaminérgico
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2009/01 - 2012/04 Purinergic control of neuroinflammation and neuroprotection afforded by the blockade of P2 receptors under excitotoxic conditions in the hippocampus
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/06 - 2011/12 Effect of purines in the developing hippocampus: consequences for the establishment of circuits related to learning and memory
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/02 - 2011/02 Estudo do sistema purinérgico glial: Modulação da MAP cinase e do transporte de adenosina em culturas de glia da retina e astrócitos cerebrais
Co-supervisor
Universidade Federal Fluminense, Brazil
2007/03 - 2010/08 A cafeína como estratégia de prevenção do declínio cognitivo em modelos animais
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2001/01 - 2010/07 Depression of synaptic transmission during hypoxia - mechanisms and relevance for neuroprotection
Co-supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2006/07 - 2009/11 Neuroprotection by adenosine receptors in aged rats – role of neuroinflammation
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2006/02 - 2009/05 Avaliação do sistema purinérgico de ratos jovens e adultos após indução de epilépsia e sua interacção com parâmetros comportamentais
Co-supervisor
Universidade Federal do Rio Grande do Sul, Brazil
2006/01 - 2009/02 Relation between metabolic alterations in the hippocampus and memory deficits induced by diabetes
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004/10 - 2008/09 Beneficial effects of caffeine consumption on diabetes-induced alterations in the hippocampus
Supervisor
Universidade de Coimbra, Portugal
2005/01 - 2008/08 Efeito dos receptores A1 e A2A de adenosina sobre alterações comportamentais, bioquímicas e morfológicas induzidas pelo estresse crónico imprevisível em camundongos
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2005/01 - 2008/03 Ecto-nucleotidases e indicadores de injúria cerebral: correlações com epilépsia e convulsões
Co-supervisor
Universidade Fderal do Rio Grande do Sul, Brazil
2003/01 - 2008/01 Neuroprotection by adenosine A2A receptors: Functional and biochemical mechanisms
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003/01 - 2007/09 Role of ATP (P2) receptors in the control of neuronal function
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005/09 - 2006/11 Envolvimento do Sistema Purinérgico, Lactato e Glicose em Insultos do Sistema Nervoso Central
Supervisor
Universidade Federal do Rio Grande do Sul Instituto de Biociências, Brazil
2002/01 - 2006/03 Interaction between purinergic and nicotinic receptors
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2000/01 - 2003/10 Adenosine receptors crosstalk in the rat hippocampus
Supervisor of Luísa Maria Vaqueiro Lopes
Universidade de Lisboa Faculdade de Ciências, Portugal

Mentoring / Tutoring

Topic Student name
2019/05 - 2021/05 post-doc: Spatiotemporal control of hippocampal synaptic plasticity by adenosine A2A receptors Francisco Manuel Queiroz Gonçalves
2017/02 - 2018/10 post-doc: Role of A2A receptors in the ergogenic effects of caffeine Aderbal Silva Aguiar Junior
2015/07 - 2018/07 post-doc: Hybrid ionotropic receptors: a new receptor concept Joana Medeiros Vieira Marques
2013/01 - 2018/01 post-doc: Role of adenosine receptors in the prefrontal cortex in an animal model of attention deficit and hyperactivity disorders Samira Cardoso Lopes Ferreira
2014/01 - 2017/07 post-doc: Adenosine A2A receptors controlling prefrontal cortical plasticity - impact on mood and memory Joana Isabel Estudante Batista Real
2014/01 - 2017/02 post-doc: Adenosine A2A receptors in the ventral brain circuits mediate behavioral inhibition promoting depressive-like conditions Nélio da Mota Gonçalves
2012/10 - 2017/02 post-doc: Adenosine A2A receptors in the dorsomedial striatum bolster behavioral inhibition promoting depressive-like mood disorders Paula Margarida Gomes Canas
2013/01 - 2017/01 post-doc: Tinkering with adenosine metabolism to manipulate adenosine neuromodulation and bolster neuroprotection in brain disorders João Pedro Oliveira da Silva Paulino Lopes
2012/11 - 2016/11 post-doc: Role of adenosine receptors in the pathophysiology of the amygdaloid complex: implications for fear conditioning and post-traumatic stress disorder Ana Patrícia Figueiredo Rocha Simões
2010/01 - 2016/04 post-doc: Neuromodulation by adenosine of synaptic plasticity Henrique Bernardo da Silva
2009/01 - 2015/08 post-doc: Interaction between adenosine A2A receptors and growth factors in the control of neurodegeneration and brain repair Catarina Alexandra Reis Vale Gomes
2013/02 - 2015/05 post-doc: Role of adenosine A2A receptors in the control of synaptic plasticity at striatal glutamatergic synapses in health and disease Daniel Rial
2012/07 - 2014/12 post-doc: Role of adenosine A2A receptors in different brain regions in the control of chronic stress neuropathology Carolina Melo de Sousa
2011/08 - 2013/05 post-doc: Presynaptic NMDA receptors - interaction with adenosine receptors Stefania Zappettini
2010/05 - 2013/04 post-doc: Role of ATP as danger signal and therapeutic potential of P2 receptors in brain disorders Daniela Pochmann
2009/07 - 2012/12 post-doc: Role of adenosine A2A receptors in glutamatergic neurons and in microglia in the control of synaptic plasticity and brain damage Ana Margarida Quaresma Fernandes Nunes
2008/10 - 2012/07 post-doc: Opposite control by caffeine and adenosine receptors of neuronal plasticity in the hippocampus and amygdala complex after stress Manuella Pinto Kaster
2011/03 - 2012/04 post-doc: Impacto do bloqueio genético ou farmacológico de receptores A2A para a adenosina num modelo de doença de Parkinson baseado na administração intra-nasal de uma toxina (MPTP) Rui Daniel Schroder Prediger
2007/04 - 2008/05 post-doc: Functional properties of co-expressed CB1 and adenosine A2A receptors in HEK293 cells Gabriele Ghisolfi
2003/01 - 2007/06 post-doc: Role of P2 receptors in the control of hippocampal and striatal function Attila Kofalvi
2003/07 - 2005/07 post-doc: Modificação de sistemas de modulação purinérgicos em modelos experimentais de epilepsia Lisiane de Oliveira Porciúncula
2004/01 - 2004/12 post-doc: Efeito da estimulação neurotóxica com cainato e LPS sobre o sistema modulatório da adenosina e o efeito neuroprotetor pelos receptores A2A Geanne Matos da Cunha
1998/09 - 1999/09 post-doc: Role of ATP in the control of neuromuscular transmission at the rat innervated hemidiaphragm Audrey Ivanenko Salgado
Distinctions

Award

2016 João José Freitas Sarkis Award
Clube Brasileiro de Purinas, Brazil
2011 Award of Teaching Excellence
MIT-Portugal, Portugal
2004 Neurodegenerative Diseases’ Award
Sociedade Portuguesa de Neurociências, Portugal
2002 Pfizer Award nomination
Laboratórios Pfizer Ltda, Brazil
2002 Young Investigator Award
Biologie Servier, France
1997 Award of Pharmacology
UCB Pharma Produtos Farmacêuticos LDA, Portugal
1995 Stimulus to Investigation Award
Fundação Calouste Gulbenkian, Portugal
1994 ‘Boa Esperança’ Award nomination
Fundação para a Ciência e a Tecnologia, Portugal

Title

2019 Honorary member
Clube Brasileiro de Purinas, Brazil