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Helena Florindo was awarded the Habilitation title in Pharmaceutical Sciences in 2018 by the University of Lisbon. She graduated in Pharmaceutical Sciences in 2003 and concluded her PhD degree in 2008 in Pharmaceutical Sciences by the University of Lisbon, in collaboration with the University of London. Currently, she is an Associate Professor with tenure and habilitation in the department of Pharmaceutics and Pharmaceutical Technology at the Faculty of Pharmacy, University of Lisbon. Since 2015, she is the head of the BioNanoSciences ¿ Drug Delivery & Immunoengineering Research Group, at the Research Institute for Medicines (iMed.ULisboa), University of Lisbon. She has been actively involved in the training of a multidisciplinary team of 17 researchers, including 4 PostDoctoral fellows, 7 PhD students, 3 master students and two traineed, with a background in Nanotechnology, Immunology, Biotechnology, Biochemistry, Polymer Sciences, Cancer Biology and Chemical Biology. Both nanotechnology and immune-oncology fields have motivated her research, which has been focused on the rational development of novel chemically defined functionalized nanobiomaterials as novel immunotherapies for cancer treatment. These nano-immunotherapies are designed to overcome multiple tumor immunosuppressive properties by attaining specific immune cell targeting in pharmacological active sites, namely tumor microenvironment (TME) and metastasis. It includes the study of the transport mechanisms and effect at the molecular level of those novel nanomedicines on dendritic cell maturation and T cell activation, the characterization of their biodistribution profiles and the evaluation of the in vivo efficacy and underlying impact on immune cell function, as adjuvants to improve the induction of an effector and specific anti-tumor immune response. Her major topics of research are: 1) Regulation of immunity by targeting dendritic cells (DCs) using nanotechnology-based tools to combine the antigen carry capacity of nanoparticles (NP) and the specific targeting and maturation of DC receptors in vivo. It aims to i) enhance antigen delivery to DC; ii) modulate antigen intracellular processing and presentation pathways; iii) block signaling pathways related to tumor evasion mechanisms; 2) Size-based targeting of lymph node-resident immune cells by nanoparticles to overcome major barriers for vaccine components and immunotherapies. 3) Characterization of bio-responsive materials impact on germinal center response to generally improve vaccine efficacy. 4) Dissecting tumor stromal and immune cell interplay to guide the design of multi-targeting nano-conjugates as innovative immunotherapeutic treatments against metastatic cancer diseases.
Identificação

Identificação pessoal

Nome completo
Helena Isabel Fialho Florindo Roque Ferreira
Data de nascimento
1979/08/17
Género
Feminino

Nomes de citação

  • Ferreira, Helena
  • Helena F Florindo
  • Helena Florindo

Identificadores de autor

Ciência ID
C512-A1B0-BE82
ORCID iD
0000-0002-4006-5840
Google Scholar ID
https://scholar.google.com/citations?user=3FL_2sQAAAAJ&hl=en
Researcher Id
E-7913-2012
Scopus Author Id
24402599300

Endereços de correio eletrónico

  • hflorindo@ff.ulisboa.pt (Profissional)
  • hflorindo@ff.ul.pt (Profissional)
  • helena.florindo@gmail.com (Pessoal)

Moradas

  • Faculdade de Farmácia Universidade de Lisboa, Instituto de Investigação do Medicamento (iMed.ULisboa) . Faculdade de Farmácia Universidade de Lisboa, Av Prof Gama Pinto, Edifício E , 1649-003, Lisboa, Lisboa, Portugal (Profissional)

Websites

  • https://imed.ulisboa.pt/labs/helena-florindo-lab/ (Profissional)

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2018
Concluído
NA (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"NA" (TESE/DISSERTAÇÃO)
Approved
2008
Concluído
Pharmaceutical Sciences (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Development of alternative micro and nanoparticulate polymeric systems for mucosal delivery of Streptococcus equi antigens" (TESE/DISSERTAÇÃO)
Pass with Distinction and Honors
2008
Concluído
Farmácia (Doutoramento)
Especialização em Especialidade: Tecnologia Farmacêutica
Universidade de Lisboa, Portugal
"Development of Alternative Micro and Nanoparticulate Polymeric Systems for Mucosal Delivery of Streptococcus Equi Antigens" (TESE/DISSERTAÇÃO)
2003
Concluído
Pharmaceutical Sciences (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"na" (TESE/DISSERTAÇÃO)
16/20 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2007/07/01 - Atual Investigador (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2020/09/10 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/11/27 - 2018/02/01 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
2008/11/26 - 2013/11/26 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2013 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008/07/26 - 2008/11/25 Assistente (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2005/09/19 - 2008/09/26 Assistente Estagiário (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2022/01/29 - Atual Presidente Spanish-Portuguese Local Chapter - Controlled Release Society, Portugal
2021/08/01 - Atual Co-Chair Controlled Release Society - Nanomedicine and Nanoscale Delivery Focus Group , Estados Unidos
2020/09/05 - Atual Associate Professor with Habilitation Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/02/01 - Atual Dirigente de laboratório, instituto, museu, centro ou observatório Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/12/01 - Atual Member of the Portuguese Medicines Evaluation Board (CAM) Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2014/01/02 - Atual Board Member of the Non-teaching staff Evaluation Board (SIADAP) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/22 - 2022/01/21 Board Member - Vice-secretary Spanish-Portuguese Local Chapter - Controlled Release Society, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/02/02 - 2020/09/30 Assistant Professor with Habilitation Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/07/28 - 2020/07/27 Secretary Treasurer Controlled Release Society - Nanomedicine and Nanoscale Delivery Focus Group , Estados Unidos
Universidade de Lisboa Faculdade de Farmácia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2015/01/01 - Atual <b>Group leader</b> of the BioNanoSciences ¿ Drug Delivery & Immunoengineering research group Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2008/11/26 - 2018/01/31 <b>Assistant Professor of Pharmaceutics</b> <b>Coordinator of Pharmaceutical Technology III in Pharmaceutical Sciences Master </b>(since 2013/2014); <b>Maternity leave</b> (5 months, December 2009/M Universidade de Lisboa Faculdade de Farmácia, Portugal
2003/10/01 - 2007/10/01 <b>PhD student </b>awarded with a FCT grant PhD fellowship POCI 2010 SFRH/BD/14370/2003 Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2022 - Atual Multifunctional nano-immunotherapy for melanoma brain metastases treatment
PTDC/BTM-SAL/4350/2021
Investigador responsável
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2022 - Atual Next-generation nanomaterials to sensitize breast cancer to immunotherapy
Referência do projeto Project reference UTAP-EXPL/NPN/0041/2021
Investigador responsável
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2020 - Atual Development of a translational COVID-19 Vaccine
LCF/TR/CD20/52700005
Investigador responsável
Universidade de Lisboa Faculdade de Farmácia, Portugal
“La Caixa” Banking Foundation
Em curso
2020 - 2021/09/30 Nanomaterials to design new vaccine adjuvants
UTA-EXPL/NPN/0082/2019
Co-Principal Investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2015 - 2018/06 Multidisciplinary strategy to develop novel multicomponent nanoscale systems for immune modulation
UTAP-ICDT/DTP-FTO/0016/2014
Ministério da Ciência, Tecnologia e Inovação
2012 - 2015/03 TherMelVac- dendritic cell-targeted peptide vaccine against melanoma by ligand-modified nanoparticles Fundação para a Ciência e a Tecnologia, I.P.
2012 - 2015/02 siRNA incorporation in a lipid/micelle-based nanocarrier as a strategy to restore E-cadherin expression and eradicate advanced breast cancer metastatic phenotype Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2014/06 Pre-clinical assays of a GAPDH-based vaccine against Group B Streptococcus infection Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2012/12 Targeting combined therapy to cancer stem cells Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2012/03 Integrated methodologies for the development of bi and three-valent DNA-vaccines against Helycobacter pylori Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2008/04 New approach on the development of an efficient vaccine against streptococcal infection by modulating the conditions of expression, production, purification and formulation Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2019 - 2022/10/31 Sensitizing pancreatic cancer to immunotherapy with multimodal precision nanomedicines
LCF/PR/HR19/52160021
Investigador responsável
Universidade de Lisboa Faculdade de Farmácia, Portugal
“La Caixa” Banking Foundation
Em curso
2017 - 2020/09/30 Modulation of melanoma-stroma interactions using a rationally-designed nanomedicine combining BRAFi-, MEKi- and immune-therapies
ENMed/0051/2016
Investigador responsável
Universidade de Lisboa Faculdade de Farmácia, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Em curso
2017 - 2019/12 MultiNano@MBM: Modulation of melanoma-stroma interactions using a rationally-designed nanomedicine combining BRAFi-, MEKi- and immune-therapies
ENMed/0051/2016
Secretaria de Estado de Ciência Tecnologia e Ensino Superior
Produções

Publicações

Artigo em revista
  1. Pozzi S; Scomparin A; Ben-Shushan D; Yeini E; Ofek P; Nahmad AD; Soffer S; et al. "MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression.". JCI insight (2022): http://europepmc.org/abstract/med/35980743.
    10.1172/jci.insight.154804
  2. Acúrcio RC; Pozzi S; Carreira B; Pojo M; Gómez-Cebrián N; Casimiro S; Fernandes A; et al. "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment.". Journal for immunotherapy of cancer (2022): http://europepmc.org/abstract/med/35863821.
    10.1136/jitc-2022-004695
  3. Satchi-Fainaro, Ronit; Florindo, Helena F.; Vicent, María J.. "Clinically-relevant and predictive cancer models for nanomedicine evaluation". Advanced Drug Delivery Reviews 183 (2022): 114140. http://dx.doi.org/10.1016/j.addr.2022.114140.
    10.1016/j.addr.2022.114140
  4. Rodolfo, Carlos; Eusébio, Dalinda; Ventura, Cathy; Nunes, Renato; Florindo, Helena F.; Costa, Diana; Sousa, Ângela. "Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System". Pharmaceutics 13 9 (2021): 1369. http://dx.doi.org/10.3390/pharmaceutics13091369.
    10.3390/pharmaceutics13091369
  5. Ðordevic, Snežana; Gonzalez, María Medel; Conejos-Sánchez, Inmaculada; Carreira, Barbara; Pozzi, Sabina; Acúrcio, Rita C.; Satchi-Fainaro, Ronit; Florindo, Helena F.; Vicent, María J.. "Current hurdles to the translation of nanomedicines from bench to the clinic". Drug Delivery and Translational Research 12 3 (2021): 500-525. http://dx.doi.org/10.1007/s13346-021-01024-2.
    10.1007/s13346-021-01024-2
  6. Ferro, Cláudio; Florindo, Helena F.; Santos, Hélder A.. "Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics". Advanced Healthcare Materials 10 16 (2021): 2100598. http://dx.doi.org/10.1002/adhm.202100598.
    10.1002/adhm.202100598
  7. Peres, Carina; Matos, Ana I.; Moura, Liane I.F.; Acúrcio, Rita C.; Carreira, Barbara; Pozzi, Sabina; Vaskovich-Koubi, Daniella; et al. "Preclinical models and technologies to advance nanovaccine development". Advanced Drug Delivery Reviews (2021): http://dx.doi.org/10.1016/j.addr.2021.03.001.
    10.1016/j.addr.2021.03.001
  8. Barbara Carreira; Rita C. Acúrcio; Ana I. Matos; Carina Peres; Sabina Pozzi; Daniella Vaskovich-Koubi; Ron Kleiner; et al. "Nanomedicines as Multifunctional Modulators of Melanoma Immune Microenvironment". Advanced Therapeutics (2021): https://doi.org/10.1002/adtp.202000147.
    10.1002/adtp.202000147
  9. Blanco-Prieto, M.J.; Florindo, H.F.. "Special Issue “A perspective of drug delivery and translational research in Europe”". Drug Delivery and Translational Research 11 2 (2021): 343-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102040462&partnerID=MN8TOARS.
    10.1007/s13346-021-00950-5
  10. Helena F. Florindo; Ron Kleiner; Daniella Vaskovich-Koubi; Rita C. Acúrcio; Barbara Carreira; Eilam Yeini; Galia Tiram; Yulia Liubomirski; Ronit Satchi-Fainaro. "Immune-mediated approaches against COVID-19". Nature Nanotechnology (2020): https://doi.org/10.1038/s41565-020-0732-3.
    10.1038/s41565-020-0732-3
  11. Martins, J.P.; das Neves, J.; de la Fuente, M.; Celia, C.; Florindo, H.; Günday-Türeli, N.; Popat, A.; et al. "The solid progress of nanomedicine". Drug Delivery and Translational Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85081606697&partnerID=MN8TOARS.
    10.1007/s13346-020-00743-2
  12. Kolesnikov M; Curato C; Zupancic E; Florindo H; Shakhar G; Jung S. "Intravital visualization of interactions of murine Peyer's Patch-resident dendritic cells with M cells.". European journal of immunology (2019): http://europepmc.org/abstract/med/31856298.
    10.1002/eji.201948332
  13. Ferreira, Helena. "Computer-aided drug design in new druggable targets for the next generation of immune-oncology therapies". (2019): http://dx.doi.org/10.1002/wcms.1397.
    10.1002/wcms.1397
  14. Ferreira, Helena. "DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node". (2019): http://dx.doi.org/10.3389/fimmu.2019.00863.
    10.3389/fimmu.2019.00863
  15. Ferreira, Helena. "Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity". (2019): http://dx.doi.org/10.3389/fphys.2018.01898.
    10.3389/fphys.2018.01898
  16. Florindo, H.F.; Madi, A.; Satchi-Fainaro, R.. "Challenges in the implementation of MIRIBEL criteria on nanobiomed manuscripts". Nature nanotechnology 14 7 (2019): 627-628. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069269890&partnerID=MN8TOARS.
    10.1038/s41565-019-0498-7
  17. Matos, A.I.; Carreira, B.; Peres, C.; Moura, L.I.F.; Conniot, J.; Fourniols, T.; Scomparin, A.; et al. "Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer". Journal of Controlled Release 307 (2019): 108-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067847585&partnerID=MN8TOARS.
    10.1016/j.jconrel.2019.06.017
  18. Conniot, J.; Scomparin, A.; Peres, C.; Yeini, E.; Pozzi, S.; Matos, A.I.; Kleiner, R.; et al. "Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators". Nature Nanotechnology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070231410&partnerID=MN8TOARS.
    10.1038/s41565-019-0512-0
  19. Acúrcio, R.C.; Leonardo-Sousa, C.; García-Sosa, A.T.; Salvador, J.A.; Florindo, H.F.; Guedes, R.C.. "Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition". MedChemComm 10 10 (2019): 1810-1818. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073807956&partnerID=MN8TOARS.
    10.1039/c9md00326f
  20. Liane I. F. Moura; Alessio Malfanti; Carina Peres; Ana I. Matos; Elise Guegain; Vanessa Sainz; Mire Zloh; et al. "Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders". Materials Horizons 6 10 (2019): 1956-1973. https://doi.org/10.1039/C9MH00628A.
    10.1039/C9MH00628A
  21. Rita C. Acúrcio; Anna Scomparin; João Conniot; Jorge A. R. Salvador; Ronit Satchi-Fainaro; Helena F. Florindo; Rita C. Guedes. "Structure–Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy". Journal of Medicinal Chemistry (2018): https://doi.org/10.1021/acs.jmedchem.8b00541.
    10.1021/acs.jmedchem.8b00541
  22. Diana Rafael; Fernanda Andrade; Sara Montero; Petra Gener; Joaquin Seras-Franzoso; Francesc Martínez; Patricia González; et al. "Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets". Precision Nanomedicine 1 2 (2018): 86-105. https://doi.org/10.29016/180629.1.
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  23. Rafael, D.; Gener, P.; Andrade, F.; Seras-Franzoso, J.; Montero, S.; Fernández, Y.; Hidalgo, M.; et al. "AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells". Drug delivery 25 1 (2018): 961-972. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053736225&partnerID=MN8TOARS.
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  24. Sainz, V.; Moura, L.I.F.; Peres, C.; Matos, A.I.; Viana, A.S.; Wagner, A.M.; Vela Ramirez, J.E.; et al. "a-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma". Acta Biomaterialia (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049319801&partnerID=MN8TOARS.
    10.1016/j.actbio.2018.06.029
  25. Zupancic, E.; Curato, C.; Kim, J.-S.; Yeini, E.; Porat, Z.; Viana, A.S.; Globerson-Levin, A.; et al. "Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer". Nanomedicine: Nanotechnology, Biology, and Medicine 14 3 (2018): 835-847. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041908606&partnerID=MN8TOARS.
    10.1016/j.nano.2017.12.011
  26. Santos, F.M.F.; Domínguez, Z.; Alcaide, M.M.; Matos, A.I.; Florindo, H.F.; Candeias, N.R.; Gois, P.M.P.; Pischel, U.. "Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes". ChemPhotoChem 2 12 (2018): 1038-1045. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068349478&partnerID=MN8TOARS.
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  27. Ferreira, Helena; Moura, L.I.F.; Martinho, N.; Silva, L.C.; Barata, T.S.; Brocchini, S.; Florindo, H.F.; Zloh, M.. "Poly-glutamic dendrimer-based conjugates for cancer vaccination - a computational design for targeted delivery of antigens.". Journal of drug targeting 25 9-10 (2017): 873-880. http://europepmc.org/abstract/med/28795601.
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  28. Zupancic, E.; Curato, C.; Paisana, M.; Rodrigues, C.; Porat, Z.; Viana, A.S.; Afonso, C.A.M.; et al. "Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming". Journal of Controlled Release 258 (2017): 182-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019758479&partnerID=MN8TOARS.
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  29. Scomparin, A.; Florindo, H.F.; Tiram, G.; Ferguson, E.L.; Satchi-Fainaro, R.. "Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives". Advanced Drug Delivery Reviews 118 (2017): 52-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029653788&partnerID=MN8TOARS.
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  30. Figueiredo, P.; Ferro, C.; Kemell, M.; Liu, Z.; Kiriazis, A.; Lintinen, K.; Florindo, H.F.; et al. "Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs". Nanomedicine 12 21 (2017): 2581-2596. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032441481&partnerID=MN8TOARS.
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    10.1002/chem.201504857
  37. Moura, L.; Martinho, N.; Barata, T.; Florindo, H.; Zloh, M.. "Computational design of a novel poly-glutamic dendrimer-based platform as an anticancer therapeutic approach". Febs Journal 283 (2016): 231-232. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000383616901326&KeyUID=WOS:000383616901326.
  38. Peres, C.; Matos, A. I.; Viana, A. S.; Graca, L.; Preat, V.; Florindo, H. F.. "Nanoparticle-based cancer vaccine to target dendritic cells and the tumor microenvironment". Febs Journal 283 (2016): 36-37. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000383616900112&KeyUID=WOS:000383616900112.
  39. Sainz, V.; Peres, C.; Ciman, T.; Rodrigues, C.; Viana, A. S.; Afonso, C. A. M.; Barata, T.; et al. "Optimization of protein loaded PLGA nanoparticle manufacturing parameters following a quality-by-design approach". Rsc Advances 6 106 (2016): 104502-104512. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000388111900076&KeyUID=WOS:000388111900076.
    10.1039/c6ra19092h
  40. Mograo, J.; Da Costa, C.A.; Gaspar, R.; Florindo, H.F.. "Modulation of dendritic cells by nanotechnology-based immunotherapeutic strategies". Journal of Biomedical Nanotechnology 12 3 (2016): 405-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959324169&partnerID=MN8TOARS.
    10.1166/jbn.2016.2157
  41. Zupancic, E.; Peres, C.; Matos, A.I.; Lopes, J.; Moreira, J.N.; Gaspar, R.S.; Florindo, H.F.; et al. "Translational peptide-associated nanosystems: Promising role as cancer vaccines". Current Topics in Medicinal Chemistry 16 3 (2016): 291-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974644157&partnerID=MN8TOARS.
    10.2174/1568026615666150701115508
  42. Rafael D; Doktorovová S; Florindo HF; Gener P; Abasolo I; Schwartz S; Videira MA. "EMT Blockage Strategies: Targeting Akt Dependent Mechanisms for Breast Cancer Metastatic Behaviour Modulation.". (2015): http://europepmc.org/abstract/med/25619882.
  43. Sainz, V.; Conniot, J.; Matos, A.I.; Peres, C.; Zupancic, E.; Moura, L.; Silva, L.C.; Florindo, H.F.; Gaspar, R.S.. "Regulatory aspects on nanomedicines". Biochemical and Biophysical Research Communications 468 3 (2015): 504-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951569805&partnerID=MN8TOARS.
    10.1016/j.bbrc.2015.08.023
  44. Silva, J.M.; Zupancic, E.; Vandermeulen, G.; Oliveira, V.G.; Salgado, A.; Videira, M.; Gaspar, M.; et al. "In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model". Journal of Controlled Release 198 (2015): 91-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918557500&partnerID=MN8TOARS.
    10.1016/j.jconrel.2014.11.033
  45. Rafael, D.; Doktorovová, S.; Florindo, H.F.; Gener, P.; Abasolo, I.; Schwartz, S.; Videira, M.A.. "EMT blockage strategies: Targeting Akt dependent mechanisms for breast cancer metastatic behaviour modulation". Current Gene Therapy 15 3 (2015): 300-312. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928941602&partnerID=MN8TOARS.
  46. Couto, A.S.; Vieira, J.; Florindo, H.F.; Videira, M.A.; Cabral-Marques, H.M.. "Characterisation of DM-ß-cyclodextrin: Prednisolone complexes and their formulation as eye drops". Journal of Inclusion Phenomena and Macrocyclic Chemistry 80 1-2 (2014): 155-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922418658&partnerID=MN8TOARS.
    10.1007/s10847-014-0420-8
  47. Martinho N; Florindo H; Silva L; Brocchini S; Zloh M; Barata T. "Molecular Modeling to Study Dendrimers for Biomedical Applications.". (2014): http://europepmc.org/abstract/med/25493631.
  48. Silva, J.M.; Vandermeulen, G.; Oliveira, V.G.; Pinto, S.N.; Rodrigues, C.; Salgado, A.; Afonso, C.A.; et al. "Development of functionalized nanoparticles for vaccine delivery to dendritic cells: A mechanistic approach". Nanomedicine 9 17 (2014): 2639-2656. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919788438&partnerID=MN8TOARS.
    10.2217/nnm.14.135
  49. Martinho, N.; Florindo, H.; Silva, L.; Brocchini, S.; Zloh, M.; Barata, T.. "Molecular modeling to study dendrimers for biomedical applications". Molecules 19 12 (2014): 20424-20467. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919742776&partnerID=MN8TOARS.
    10.3390/molecules191220424
  50. Conniot J; Silva JM; Fernandes JG; Silva LC; Gaspar R; Brocchini S; Florindo HF; Barata TS. "Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking.". (2014): http://europepmc.org/abstract/med/25505783.
    10.3389/fchem.2014.00105
  51. Silva, J.M.; Videira, M.; Gaspar, R.; Préat, V.; Florindo, H.F.. "Immune system targeting by biodegradable nanoparticles for cancer vaccines". Journal of Controlled Release 168 2 (2013): 179-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877945468&partnerID=MN8TOARS.
    10.1016/j.jconrel.2013.03.010
  52. Rodrigues, M.A.; Figueiredo, L.; Padrela, L.; Cadete, A.; Tiago, J.; Matos, H.A.; Azevedo, E.G.D.; et al. "Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model". European Journal of Pharmaceutics and Biopharmaceutics 82 2 (2012): 392-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867877552&partnerID=MN8TOARS.
    10.1016/j.ejpb.2012.07.005
  53. Bettencourt, A.; Florindo, H.F.; Ferreira, I.F.S.; Matos, A.; Monteiro, J.; Neves, C.; Lopes, P.; et al. "Incorporation of tocopherol acetate-containing particles in acrylic bone cement". Journal of Microencapsulation 27 6 (2010): 533-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955433425&partnerID=MN8TOARS.
    10.3109/02652048.2010.484106
  54. Florindo, H.F.; Pandit, S.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "Surface modified polymeric nanoparticles for immunisation against equine strangles". International Journal of Pharmaceutics 390 1 (2010): 25-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951255224&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2009.10.009
  55. Florindo, H.F.; Pandit, S.; Lacerda, L.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "The enhancement of the immune response against S. equi antigens through the intranasal administration of poly-e-caprolactone-based nanoparticles". Biomaterials 30 5 (2009): 879-891. http://www.scopus.com/inward/record.url?eid=2-s2.0-57549114032&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2008.10.035
  56. Florindo, H.F.; Pandit, S.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "New approach on the development of a mucosal vaccine against strangles: Systemic and mucosal immune responses in a mouse model". Vaccine 27 8 (2009): 1230-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749108436&partnerID=MN8TOARS.
    10.1016/j.vaccine.2008.12.004
  57. Florindo, H.F.; Pandit, S.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "Streptococcus equi antigens adsorbed onto surface modified poly-e-caprolactone microspheres induce humoral and cellular specific immune responses". Vaccine 26 33 (2008): 4168-4177. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149110539&partnerID=MN8TOARS.
    10.1016/j.vaccine.2008.05.074
Capítulo de livro
  1. Marques, J.M.; Nunes, R.; Florindo, H.; Ferreira, D.; Sarmento, B.. "A demanding path from iPSCs toward pancreatic ß- and a-cells". 227-256. 2021.
  2. Lambricht, L.; Peres, C.; Florindo, H.; Préat, V.; Vandermeulen, G.. "Polymer-Based Nanoparticles as Modern Vaccine Delivery Systems". In Micro and Nanotechnology in Vaccine Development, 185-203. Elsevier, 2017.
    10.1016/b978-0-323-39981-4.00010-5
  3. Gaspar, Diana; Peres, Carina; Florindo, Helena; Almeida, António. "Mucosal Immunization Using Polyester-Based Particulate Systems". In Handbook of Polyester Drug Delivery Systems, 521-561. Pan Stanford, 2016.
    10.1201/b20045-17
  4. Helena F Florindo; Ana Ester Ventura; Tânia Santos; Ana Carreira; Nuno Martinho; João Conniot; Ana Raquel Varela; et al. "Drugs, delivery systems and membrane organization in model and cell membranes". In Membrane organization and lipid rafts in the cell and artificial membranes. New York, Estados Unidos: Nova Science Publishers Inc, 2016.
  5. Helena F Florindo; Joana Silva; Véronique Préat. "Role of the aliphatic polyesters as particulate vaccine delivery systems.". In Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. CRC Press, 2015.
  6. Ferreira, Helena. "Regulatory aspects of oncologicals". 2014.
    10.1007/978-3-319-08084-0_15
  7. Helena F Florindo; Joana Silva; Eva Zupancic; Carina Peres; Rogério Gaspar; Véronique Préat. "Immunomodulation against microbial pathogens through dendritic cells". In Microbial pathogens and strategies for combating them: science, technology and education. Formatex Research Center, 2013.
  8. Ferreira, Helena. "Nanostructures overcoming the nasal barrier: Physiological considerations and mechanistic issues.". Reino Unido, 2012.
    10.1039/9781849735292-00117
  9. Almeida*, António J.; Florindo, Helena F.. "Chapter 3.1. Nanocarriers Overcoming the Nasal Barriers: Physiological Considerations and Mechanistic Issues". In Nanostructured Biomaterials for Overcoming Biological Barriers, 117-132. Royal Society of Chemistry, 2012.
    10.1039/9781849735292-00117
Livro
  1. Silva, A.L.; Moura, L.I.F.; Carreira, B.; Conniot, J.; Matos, A.I.; Peres, C.; Sainz, V.; et al. Functional Moieties for Intracellular Traffic of Nanomaterials. Elsevier. 2018.
    10.1016/b978-0-323-50878-0.00014-8
  2. Florindo, H.F.; Lopes, J.; Silva, L.C.; Corvo, M.L.; Martins, M.B.; Gaspar, R.. Regulatory Development of Nanotechnology-Based Vaccines. Elsevier. 2017.
    10.1016/b978-0-323-39981-4.00021-x
  3. Gaspar, D.; Peres, C.; Florindo, H.; Almeida, A.J.. Mucosal immunization using polyester-based particulate systems. 2016.
    10.4032/9789814669665
Pré-impressão
  1. Kumar S; Basto AP; Ribeiro F; Almeida SCP; Campos P; Peres C; Al-Khalidi S; et al. "Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue". Pré-impressão. 2022. http://europepmc.org/abstract/PPR/PPR525995.
    10.1101/2022.07.28.501817
Tese / Dissertação
  1. Florindo, Helena Isabel Fialho, 1979-. "Development of alternative micro and nanoparticulate polymeric systems for mucosal delivery of Streptococcus equi antigens". Doutoramento, 2008. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000542728.

Propriedade Intelectual

Pedido provisório de patente
  1. 2019. "Polymeric Nanovaccines and used thereof".
    Protegido

Outros

Outra produção
  1. Antibody and cytokine-associated immune responses to S. equi antigens entrapped in PLA nanospheres. Strangles is an infectious disease caused by Streptococcus equi subspecies equi that affects the upper respiratory tract of the Equidae. The control of this disease seems to be dependent on its earlier detection and prevention, but prolonged animal protection without development of strong and severe side effects has not yet been achieved. Convalescent horses exhibit a protective immune response, m. 2009. Florindo, Helena F.; Pandit, Sreenivas; Goncalves, Lidia M. D.; Videira, Mafalda; Alpar, Oya; Almeida, Antonio J.; Florindo, H.F.; et al. http://hdl.handle.net/10451/20980.
    http://dx.doi.org/10.1016/j.biomaterials.2009.05.045
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020/02/01 - Atual Viral Envelopes Coating HPMA-Selenium Nanoparticles for Cancer Targeting Therapy
Orientador de Cláudio Ferro
PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/12 - Atual Alteração da estratégia de controlo de qualidade de medicamentos para real-time release
Orientador de Tânia Freire
M.Sc. in Pharmaceutical Engineering (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/01 - Atual Using co-creation to identify technology-based solutions to improve medication adherence against breast cancer
Coorientador de Catarina Bernardo
PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Atual Small molecules for cancer immunotherapy: A melanoma approach
Orientador de Lara Serronha
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Atual Combination immunotherapy against Pancreatic Cancer
Orientador de Inês Vilar
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Atual Nano-delivery approach for targeting type 1 collagen in breast cancer microenvironment
Orientador de Mafalda Verdial
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Atual Nano-vaccine combined with nano-based delivery of siRNA targeting GLUT-1 and miRNA-143 for the treatment of colorectal cancer
Orientador de Raquel Coelho
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/12/01 - Atual Modulation of tumor microenvironment using nanovaccine
Orientador de Madalena Alves
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2020/04/30 COMBI_CRC: Combinatorial multivalent nanoplatform for colorectal cancer treatment
Orientador de Ana Isabel Neves de Matos
Engenharia Biomédica (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/09/01 - 2019/12/12 Multifunctional nano-vaccines against melanoma
Orientador de Ana Filipa Gonçalves
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/01 - 2019/12/01 Impact of the Modulation of Tumor Vasculature on Cancer Vaccine Efficacy
Orientador de Sandra Pena
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/01 - 2019/12/01 Combinational vaccines against colorectal cancer
Orientador de Mariana Mateus
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2019/12 Discovery and Development of Novel Small-Molecule Immune System Modulators
Coorientador de Ana Rita de Carvalho Acúrcio
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2019 Multistage pancreas biomimetic construct based on synergism of functionalized nanomedicines and cell differentiation
Coorientador de Joana Beatriz Antunes Moreira Carvalho Marques
Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/09/01 - 2016/01/05 Biomembranes as barrier for therapeutic entities
Coorientador de Melissa Sirage
M.Sc. in Biomedical Engineering (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2015 Multicomponent Particulates for Immune Modulation
Orientador de João Miguel de Oliveira Conniot
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09/01 - 2014/12/01 Development of nanosystems for HIV vaccine delivery
Coorientador de Ana Isabel Matos
M.Sc. in Biochemistry (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2014 Development of a Melanoma Therapeutic Vaccine Candidate by the Coencapsulation of Melanoma Antigen Peptides and Toll-like Receptor Ligands as Adjuvants into Polymeric Nanoparticles
Orientador de Joana Catarina Mendão Azeitão da Silva
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Intracellularly-targeted nanoplatform to target dendritic cells and for immunomodulation
Orientador de Carina Sofia Gonçalves Peres
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Anti-tumor immunity induced by a novel nanoparticulate vaccine: a mechanism approach
Orientador de Eva Zupancic
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Hybrid lipid-polymeric nanoplatform as cancer immunotherapeutics
Orientador de Vanessa Gameiro Sainz
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 AKT2 siRNA-nanoparticulate system as a new tool to restoration of E-cadherin and eradicate tumour metastic phenotype
Coorientador de Diana Fernandes de Sousa Rafael
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2021/10/15 - 2021/10/15 Cutaneous Melanoma: from where to where? Liga Portuguesa COntra o Cancro

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2016/12/01 - Atual Clinical Expert (Pharmacokinetics and Biodistribution) involved in the evalauation of Common Technical Documents related to the approval of Medicines
Avaliador
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2021/02/03 Interview regarding the developmento fo a COVID-19 vaccine Público newspaper
2020/09/21 Interview to Jornal Observador related to the COVID-19 project awarded by La CAixa FOundation
2019/08/06 News regarding the publication of the Nature Nanotechnology paper on the development of our cancer nano-vaccine against melanoma
2019/08/06 On the RTP journal news on the development of our cancer nano-vaccine, following the publication of our results on Nature Nanotechnology paper RTP News national journal (afternoon and night emission)
2019/08/06 Several news published worldwide regarding our nano-vaccine against melanoma Several news in several countries: israel, USA etc..

Entrevista / Programa (rádio / tv)

Programa Tema
2021/02/24 - Atual The Old Friends - Antena 1 COVID-19
2020/04/28 - Atual Programa Sociedade Civil -RTP2 Cancer nanovaccine research to fight melanoma
2019/08/06 - Atual News emission on TVI national agency - News on the development of our cancer nano-vaccine, following the publication of our results on Nature Nanotechnology paper Cancer Vaccine against melanoma
2019/08/05 - Atual RTP 3 Nanovaccine against melanoma
2019/08/05 - Atual News on the development of our cancer nano-vaccine, following the publication of our results on Nature Nanotechnology paper RTP

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2020/02/01 - Atual Executive Board Member
Membro
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2020/02/01 - Atual Executive Board Member
Vogal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Distinções

Prémio

2020 Young Investigator Immunology
Controlled Release Society - Nanomedicine and Nanoscale Delivery Focus Group , Estados Unidos
2015 Gene therapy for HIV cure: two complementary strategies delivered by self-amplifying RNA vectors
2014 COMBI-VIH: multivalent nanoplatform for immunomodulation to control HIV infection.
Gilead Program Award , Portugal

Outra distinção

2019 Scientific achievements featured in the national and international press
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Young Scientist Award for the best oral communication award
2015 Best Poster award
2013 Best poster award
2013 Best oral communication
2013 Best poster award
2011 Best Oral commmunication award
2009 Grant awarded to participate in the “2nd ESF/UB European Summer School on Nanomedicine”, Lisboa, Portugal (2009).
2007 Research activity mentioned in the international press: McCluskey, M (2007). New vaccine technology. Equus Magazine, 352 (January): 10.
2006 Best Oral commmunication award
2005 Nomination for Controlled Release Society's Outstanding Veterinary Paper Award