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Helena Florindo was awarded the Habilitation title in Pharmaceutical Sciences in 2018 by the University of Lisbon. She graduated in Pharmaceutical Sciences in 2003 and concluded her Ph.D. degree in 2008 in Pharmaceutical Sciences by the University of Lisbon, in collaboration with the University of London. Currently, she is a Full Professor in the Department of Pharmaceutics and Pharmaceutical Technology at the Faculty of Pharmacy, University of Lisbon. Since 2015, she has been the head of the BioNanoSciences ¿ Drug Delivery & Immunoengineering Research Group, at the Research Institute for Medicines (iMed.ULisboa), University of Lisbon. She has been actively involved in the training of a multidisciplinary team of 17 researchers, including 4 PostDoctoral fellows, 10 Ph.D. students, 4 master students, and two trainees, with a background in Nanotechnology, Immunology, Biotechnology, Biochemistry, Polymer Sciences, Cancer Biology and Chemical Biology. Both nanotechnology and immune-oncology fields have motivated her research, which has been focused on the rational development of novel chemically defined functionalized nanobiomaterials as novel immunotherapies for cancer treatment. These nano-immunotherapies are designed to overcome multiple tumor immunosuppressive properties by attaining specific immune cell targeting in pharmacological active sites, namely tumor microenvironment (TME) and metastasis. It includes the study of the transport mechanisms and effect at the molecular level of those novel nanomedicines on dendritic cell maturation and T cell activation, the characterization of their biodistribution profiles, and the evaluation of the in vivo efficacy and underlying impact on immune cell function, as adjuvants to improve the induction of an effector and specific anti-tumor immune response. Her major topics of research are: 1) Regulation of immunity by targeting dendritic cells (DCs) using nanotechnology-based tools to combine the antigen carry capacity of nanoparticles (NP) and the specific targeting and maturation of DC receptors in vivo. It aims to i) enhance antigen delivery to DC; ii) modulate antigen intracellular processing and presentation pathways; iii) block signaling pathways related to tumor evasion mechanisms; 2) Size-based targeting of lymph node-resident immune cells by nanoparticles to overcome major barriers for vaccine components and immunotherapies. 3) Characterization of bio-responsive materials impact on germinal center response to generally improve vaccine efficacy. 4) Dissecting tumor stromal and immune cell interplay to guide the design of multi-targeting nano-conjugates as innovative immunotherapeutic treatments against metastatic cancer diseases.
Identification

Personal identification

Full name
Helena Isabel Fialho Florindo Roque Ferreira
Date of birth
1979/08/17
Gender
Female

Citation names

  • Ferreira, Helena
  • Helena F Florindo
  • Helena Florindo

Author identifiers

Ciência ID
C512-A1B0-BE82
ORCID iD
0000-0002-4006-5840
Google Scholar ID
https://scholar.google.com/citations?user=3FL_2sQAAAAJ&hl=en
Researcher Id
E-7913-2012
Scopus Author Id
24402599300

Email addresses

  • hflorindo@ff.ulisboa.pt (Professional)
  • hflorindo@ff.ul.pt (Professional)
  • helena.florindo@gmail.com (Personal)

Addresses

  • Faculdade de Farmácia Universidade de Lisboa, Instituto de Investigação do Medicamento (iMed.ULisboa) . Faculdade de Farmácia Universidade de Lisboa, Av Prof Gama Pinto, Edifício E , 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Nano-technology
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2018
Concluded
NA (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"NA" (THESIS/DISSERTATION)
Approved
2008
Concluded
Pharmaceutical Sciences (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Development of alternative micro and nanoparticulate polymeric systems for mucosal delivery of Streptococcus equi antigens" (THESIS/DISSERTATION)
Pass with Distinction and Honors
2008
Concluded
Farmácia (Doutoramento)
Major in Especialidade: Tecnologia Farmacêutica
Universidade de Lisboa, Portugal
"Development of Alternative Micro and Nanoparticulate Polymeric Systems for Mucosal Delivery of Streptococcus Equi Antigens" (THESIS/DISSERTATION)
2003
Concluded
Pharmaceutical Sciences (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"na" (THESIS/DISSERTATION)
16/20 valores
Affiliation

Science

Category
Host institution
Employer
2007/07/01 - Current Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2023/08/28 - Current Full Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/10 - 2023/08/27 Associate Professor (University Teacher) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/11/27 - 2018/02/01 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
2008/11/26 - 2013/11/26 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2013 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008/07/26 - 2008/11/25 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2005/09/19 - 2008/09/26 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Positions / Appointments

Category
Host institution
Employer
2023/07/01 - Current Chair Controlled Release Society - Nanomedicine and Nanoscale Delivery Focus Group , United States
2022/01/29 - Current President Spanish-Portuguese Local Chapter - Controlled Release Society, Portugal
2020/02/01 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/12/01 - Current Member of the Portuguese Medicines Evaluation Board (CAM) Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2014/01/02 - Current Board Member of the Non-teaching staff Evaluation Board (SIADAP) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/05 - 2023/08/27 Associate Professor with Habilitation Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/08/01 - 2023/06/30 Co-Chair Controlled Release Society - Nanomedicine and Nanoscale Delivery Focus Group , United States
2020/01/22 - 2022/01/21 Board Member - Vice-secretary Spanish-Portuguese Local Chapter - Controlled Release Society, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/02/02 - 2020/09/30 Assistant Professor with Habilitation Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/07/28 - 2020/07/27 Secretary Treasurer Controlled Release Society - Nanomedicine and Nanoscale Delivery Focus Group , United States
Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution
Employer
2015/01/01 - Current <b>Group leader</b> of the BioNanoSciences ¿ Drug Delivery & Immunoengineering research group Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2008/11/26 - 2018/01/31 <b>Assistant Professor of Pharmaceutics</b> <b>Coordinator of Pharmaceutical Technology III in Pharmaceutical Sciences Master </b>(since 2013/2014); <b>Maternity leave</b> (5 months, December 2009/M Universidade de Lisboa Faculdade de Farmácia, Portugal
2003/10/01 - 2007/10/01 <b>PhD student </b>awarded with a FCT grant PhD fellowship POCI 2010 SFRH/BD/14370/2003 Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2022/12/01 - Current Multifunctional nano-immunotherapy against breast brain metastases
LCF/PR/HR22/52420016
Principal investigator
“La Caixa” Banking Foundation, Spain
“La Caixa” Banking Foundation
Ongoing
2022/01/17 - Current Multifunctional nano-immunotherapy for melanoma brain metastases treatment
PTDC/BTM-SAL/4350/2021
Principal investigator
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2020/08/10 - Current Development of a translational COVID-19 Vaccine
LCF/TR/CD20/52700005
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
“La Caixa” Banking Foundation
Ongoing
2022/01/01 - 2023/07/05 Next-generation nanomaterials to sensitize breast cancer to immunotherapy
UTAP-EXPL/NPN/0041/2021
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2020/10/01 - 2021/09/30 Nanomaterials to design new vaccine adjuvants
UTA-EXPL/NPN/0082/2019
Co-Principal Investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2015/06 - 2018/06 Multidisciplinary strategy to develop novel multicomponent nanoscale systems for immune modulation
UTAP-ICDT/DTP-FTO/0016/2014
Ministério da Ciência, Tecnologia e Inovação
2012/03 - 2015/03 TherMelVac- dendritic cell-targeted peptide vaccine against melanoma by ligand-modified nanoparticles Fundação para a Ciência e a Tecnologia, I.P.
2012/02 - 2015/02 siRNA incorporation in a lipid/micelle-based nanocarrier as a strategy to restore E-cadherin expression and eradicate advanced breast cancer metastatic phenotype Fundação para a Ciência e a Tecnologia, I.P.
2011/01 - 2014/06 Pre-clinical assays of a GAPDH-based vaccine against Group B Streptococcus infection Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2012/12 Targeting combined therapy to cancer stem cells Fundação para a Ciência e a Tecnologia, I.P.
2007/09 - 2012/03 Integrated methodologies for the development of bi and three-valent DNA-vaccines against Helycobacter pylori Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2008/04 New approach on the development of an efficient vaccine against streptococcal infection by modulating the conditions of expression, production, purification and formulation Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2019/11/01 - 2022/10/31 Sensitizing pancreatic cancer to immunotherapy with multimodal precision nanomedicines
LCF/PR/HR19/52160021
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
“La Caixa” Banking Foundation
Ongoing
2017/01 - 2019/12 MultiNano@MBM: Modulation of melanoma-stroma interactions using a rationally-designed nanomedicine combining BRAFi-, MEKi- and immune-therapies
ENMed/0051/2016
Secretaria de Estado de Ciência Tecnologia e Ensino Superior
Outputs

Publications

Book
  1. Silva, A.L.; Moura, L.I.F.; Carreira, B.; Conniot, J.; Matos, A.I.; Peres, C.; Sainz, V.; et al. Functional Moieties for Intracellular Traffic of Nanomaterials. Elsevier. 2018.
    10.1016/b978-0-323-50878-0.00014-8
  2. Florindo, H.F.; Lopes, J.; Silva, L.C.; Corvo, M.L.; Martins, M.B.; Gaspar, R.. Regulatory Development of Nanotechnology-Based Vaccines. Elsevier. 2017.
    10.1016/b978-0-323-39981-4.00021-x
  3. Gaspar, D.; Peres, C.; Florindo, H.; Almeida, A.J.. Mucosal immunization using polyester-based particulate systems. 2016.
    10.4032/9789814669665
Book chapter
  1. Marques, J.M.; Nunes, R.; Florindo, H.; Ferreira, D.; Sarmento, B.. "A demanding path from iPSCs toward pancreatic ß- and a-cells". 227-256. 2021.
  2. Lambricht, L.; Peres, C.; Florindo, H.; Préat, V.; Vandermeulen, G.. "Polymer-Based Nanoparticles as Modern Vaccine Delivery Systems". In Micro and Nanotechnology in Vaccine Development, 185-203. Elsevier, 2017.
    10.1016/b978-0-323-39981-4.00010-5
  3. Gaspar, Diana; Peres, Carina; Florindo, Helena; Almeida, António. "Mucosal Immunization Using Polyester-Based Particulate Systems". In Handbook of Polyester Drug Delivery Systems, 521-561. Pan Stanford, 2016.
    10.1201/b20045-17
  4. Helena F Florindo; Ana Ester Ventura; Tânia Santos; Ana Carreira; Nuno Martinho; João Conniot; Ana Raquel Varela; et al. "Drugs, delivery systems and membrane organization in model and cell membranes". In Membrane organization and lipid rafts in the cell and artificial membranes. New York, United States: Nova Science Publishers Inc, 2016.
  5. Helena F Florindo; Joana Silva; Véronique Préat. "Role of the aliphatic polyesters as particulate vaccine delivery systems.". In Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. CRC Press, 2015.
  6. Ferreira, Helena. "Regulatory aspects of oncologicals". 2014.
    10.1007/978-3-319-08084-0_15
  7. Helena F Florindo; Joana Silva; Eva Zupancic; Carina Peres; Rogério Gaspar; Véronique Préat. "Immunomodulation against microbial pathogens through dendritic cells". In Microbial pathogens and strategies for combating them: science, technology and education. Formatex Research Center, 2013.
  8. Ferreira, Helena. "Nanostructures overcoming the nasal barrier: Physiological considerations and mechanistic issues.". United Kingdom, 2012.
    10.1039/9781849735292-00117
  9. Almeida*, António J.; Florindo, Helena F.. "Chapter 3.1. Nanocarriers Overcoming the Nasal Barriers: Physiological Considerations and Mechanistic Issues". In Nanostructured Biomaterials for Overcoming Biological Barriers, 117-132. Royal Society of Chemistry, 2012.
    10.1039/9781849735292-00117
Journal article
  1. Matos, Ana I.; Peres, Carina; Carreira, Barbara; Moura, Liane I. F.; Acúrcio, Rita C.; Vogel, Theresa; Wegener, Erik; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): http://dx.doi.org/10.1002/advs.202300299.
    10.1002/advs.202300299
  2. Pires, David; Mandal, Manoj; Matos, Ana I.; Peres, Carina; Catalão, Maria João; Azevedo-Pereira, José Miguel; Satchi-Fainaro, Ronit; Florindo, Helena F.; Anes, Elsa. "Development of Chitosan Particles Loaded with siRNA for Cystatin C to Control Intracellular Drug-Resistant Mycobacterium tuberculosis". Antibiotics 12 4 (2023): 729. http://dx.doi.org/10.3390/antibiotics12040729.
    10.3390/antibiotics12040729
  3. Carreira, Barbara; Acúrcio, Rita A.; Pozzi, Sabina; Kleiner, Ron; Moura, Liane I.; Matos, Ana I.; vaskovich, Daniela; et al. "Abstract 835: Translational nanotechnology-based cancer vaccine to re-educate host immune response against metastatic cancers". Cancer Research 83 7_Suppleme (2023): 835-835. http://dx.doi.org/10.1158/1538-7445.am2023-835.
    10.1158/1538-7445.am2023-835
  4. Yeini, Eilam; Vaskovich-Koubi, Daniella; Kleiner, Ron; Florindo, Helena F.; Satchi-Fainaro, Ronit. "Abstract 3243: Modulating the brain immune system to fight cancer in 3 dimensions". Cancer Research 83 7_Suppleme (2023): 3243-3243. http://dx.doi.org/10.1158/1538-7445.am2023-3243.
    10.1158/1538-7445.am2023-3243
  5. Marques, J.; Nunes, R.; Carvalho, M.; Neves, J.; Florindo, H.; Ferreira, D.; Sarmento, B.. "IDF2022-1023 Development of GLP-1 loaded nanoparticles in a bioartificial pancreas to treat type I Diabetes". Diabetes Research and Clinical Practice 197 (2023): 110285. http://dx.doi.org/10.1016/j.diabres.2023.110285.
    10.1016/j.diabres.2023.110285
  6. Pozzi S; Scomparin A; Ben-Shushan D; Yeini E; Ofek P; Nahmad AD; Soffer S; et al. "MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression.". JCI insight (2022): http://europepmc.org/abstract/med/35980743.
    10.1172/jci.insight.154804
  7. Acúrcio RC; Pozzi S; Carreira B; Pojo M; Gómez-Cebrián N; Casimiro S; Fernandes A; et al. "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment.". Journal for immunotherapy of cancer (2022): http://europepmc.org/abstract/med/35863821.
    10.1136/jitc-2022-004695
  8. Satchi-Fainaro, Ronit; Florindo, Helena F.; Vicent, María J.. "Clinically-relevant and predictive cancer models for nanomedicine evaluation". Advanced Drug Delivery Reviews 183 (2022): 114140. http://dx.doi.org/10.1016/j.addr.2022.114140.
    10.1016/j.addr.2022.114140
  9. Rodolfo, Carlos; Eusébio, Dalinda; Ventura, Cathy; Nunes, Renato; Florindo, Helena F.; Costa, Diana; Sousa, Ângela. "Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System". Pharmaceutics 13 9 (2021): 1369. http://dx.doi.org/10.3390/pharmaceutics13091369.
    10.3390/pharmaceutics13091369
  10. Ðordevic, Snežana; Gonzalez, María Medel; Conejos-Sánchez, Inmaculada; Carreira, Barbara; Pozzi, Sabina; Acúrcio, Rita C.; Satchi-Fainaro, Ronit; Florindo, Helena F.; Vicent, María J.. "Current hurdles to the translation of nanomedicines from bench to the clinic". Drug Delivery and Translational Research 12 3 (2021): 500-525. http://dx.doi.org/10.1007/s13346-021-01024-2.
    10.1007/s13346-021-01024-2
  11. Ferro, Cláudio; Florindo, Helena F.; Santos, Hélder A.. "Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics". Advanced Healthcare Materials 10 16 (2021): 2100598. http://dx.doi.org/10.1002/adhm.202100598.
    10.1002/adhm.202100598
  12. Peres, Carina; Matos, Ana I.; Moura, Liane I.F.; Acúrcio, Rita C.; Carreira, Barbara; Pozzi, Sabina; Vaskovich-Koubi, Daniella; et al. "Preclinical models and technologies to advance nanovaccine development". Advanced Drug Delivery Reviews (2021): http://dx.doi.org/10.1016/j.addr.2021.03.001.
    10.1016/j.addr.2021.03.001
  13. Barbara Carreira; Rita C. Acúrcio; Ana I. Matos; Carina Peres; Sabina Pozzi; Daniella Vaskovich-Koubi; Ron Kleiner; et al. "Nanomedicines as Multifunctional Modulators of Melanoma Immune Microenvironment". Advanced Therapeutics (2021): https://doi.org/10.1002/adtp.202000147.
    10.1002/adtp.202000147
  14. Blanco-Prieto, M.J.; Florindo, H.F.. "Special Issue “A perspective of drug delivery and translational research in Europe”". Drug Delivery and Translational Research 11 2 (2021): 343-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102040462&partnerID=MN8TOARS.
    10.1007/s13346-021-00950-5
  15. Helena F. Florindo; Ron Kleiner; Daniella Vaskovich-Koubi; Rita C. Acúrcio; Barbara Carreira; Eilam Yeini; Galia Tiram; Yulia Liubomirski; Ronit Satchi-Fainaro. "Immune-mediated approaches against COVID-19". Nature Nanotechnology (2020): https://doi.org/10.1038/s41565-020-0732-3.
    10.1038/s41565-020-0732-3
  16. Martins, J.P.; das Neves, J.; de la Fuente, M.; Celia, C.; Florindo, H.; Günday-Türeli, N.; Popat, A.; et al. "The solid progress of nanomedicine". Drug Delivery and Translational Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85081606697&partnerID=MN8TOARS.
    10.1007/s13346-020-00743-2
  17. Kolesnikov M; Curato C; Zupancic E; Florindo H; Shakhar G; Jung S. "Intravital visualization of interactions of murine Peyer's Patch-resident dendritic cells with M cells.". European journal of immunology (2019): http://europepmc.org/abstract/med/31856298.
    10.1002/eji.201948332
  18. Ferreira, Helena. "Computer-aided drug design in new druggable targets for the next generation of immune-oncology therapies". (2019): http://dx.doi.org/10.1002/wcms.1397.
    10.1002/wcms.1397
  19. Ferreira, Helena. "DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node". (2019): http://dx.doi.org/10.3389/fimmu.2019.00863.
    10.3389/fimmu.2019.00863
  20. Ferreira, Helena. "Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity". (2019): http://dx.doi.org/10.3389/fphys.2018.01898.
    10.3389/fphys.2018.01898
  21. Florindo, H.F.; Madi, A.; Satchi-Fainaro, R.. "Challenges in the implementation of MIRIBEL criteria on nanobiomed manuscripts". Nature nanotechnology 14 7 (2019): 627-628. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069269890&partnerID=MN8TOARS.
    10.1038/s41565-019-0498-7
  22. Matos, A.I.; Carreira, B.; Peres, C.; Moura, L.I.F.; Conniot, J.; Fourniols, T.; Scomparin, A.; et al. "Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer". Journal of Controlled Release 307 (2019): 108-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067847585&partnerID=MN8TOARS.
    10.1016/j.jconrel.2019.06.017
  23. Conniot, J.; Scomparin, A.; Peres, C.; Yeini, E.; Pozzi, S.; Matos, A.I.; Kleiner, R.; et al. "Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators". Nature Nanotechnology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070231410&partnerID=MN8TOARS.
    10.1038/s41565-019-0512-0
  24. Acúrcio, R.C.; Leonardo-Sousa, C.; García-Sosa, A.T.; Salvador, J.A.; Florindo, H.F.; Guedes, R.C.. "Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition". MedChemComm 10 10 (2019): 1810-1818. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073807956&partnerID=MN8TOARS.
    10.1039/c9md00326f
  25. Liane I. F. Moura; Alessio Malfanti; Carina Peres; Ana I. Matos; Elise Guegain; Vanessa Sainz; Mire Zloh; et al. "Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders". Materials Horizons 6 10 (2019): 1956-1973. https://doi.org/10.1039/C9MH00628A.
    10.1039/C9MH00628A
  26. Rita C. Acúrcio; Anna Scomparin; João Conniot; Jorge A. R. Salvador; Ronit Satchi-Fainaro; Helena F. Florindo; Rita C. Guedes. "Structure–Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy". Journal of Medicinal Chemistry (2018): https://doi.org/10.1021/acs.jmedchem.8b00541.
    10.1021/acs.jmedchem.8b00541
  27. Diana Rafael; Fernanda Andrade; Sara Montero; Petra Gener; Joaquin Seras-Franzoso; Francesc Martínez; Patricia González; et al. "Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets". Precision Nanomedicine 1 2 (2018): 86-105. https://doi.org/10.29016/180629.1.
    10.29016/180629.1
  28. Rafael, D.; Gener, P.; Andrade, F.; Seras-Franzoso, J.; Montero, S.; Fernández, Y.; Hidalgo, M.; et al. "AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells". Drug delivery 25 1 (2018): 961-972. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053736225&partnerID=MN8TOARS.
    10.1080/10717544.2018.1461276
  29. Sainz, V.; Moura, L.I.F.; Peres, C.; Matos, A.I.; Viana, A.S.; Wagner, A.M.; Vela Ramirez, J.E.; et al. "a-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma". Acta Biomaterialia (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049319801&partnerID=MN8TOARS.
    10.1016/j.actbio.2018.06.029
  30. Zupancic, E.; Curato, C.; Kim, J.-S.; Yeini, E.; Porat, Z.; Viana, A.S.; Globerson-Levin, A.; et al. "Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer". Nanomedicine: Nanotechnology, Biology, and Medicine 14 3 (2018): 835-847. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041908606&partnerID=MN8TOARS.
    10.1016/j.nano.2017.12.011
  31. Santos, F.M.F.; Domínguez, Z.; Alcaide, M.M.; Matos, A.I.; Florindo, H.F.; Candeias, N.R.; Gois, P.M.P.; Pischel, U.. "Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes". ChemPhotoChem 2 12 (2018): 1038-1045. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068349478&partnerID=MN8TOARS.
    10.1002/cptc.201800150
  32. Ferreira, Helena; Moura, L.I.F.; Martinho, N.; Silva, L.C.; Barata, T.S.; Brocchini, S.; Florindo, H.F.; Zloh, M.. "Poly-glutamic dendrimer-based conjugates for cancer vaccination - a computational design for targeted delivery of antigens.". Journal of drug targeting 25 9-10 (2017): 873-880. http://europepmc.org/abstract/med/28795601.
    10.1080/1061186x.2017.1363213
  33. Zupancic, E.; Curato, C.; Paisana, M.; Rodrigues, C.; Porat, Z.; Viana, A.S.; Afonso, C.A.M.; et al. "Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming". Journal of Controlled Release 258 (2017): 182-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019758479&partnerID=MN8TOARS.
    10.1016/j.jconrel.2017.05.014
  34. Scomparin, A.; Florindo, H.F.; Tiram, G.; Ferguson, E.L.; Satchi-Fainaro, R.. "Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives". Advanced Drug Delivery Reviews 118 (2017): 52-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029653788&partnerID=MN8TOARS.
    10.1016/j.addr.2017.09.011
  35. Figueiredo, P.; Ferro, C.; Kemell, M.; Liu, Z.; Kiriazis, A.; Lintinen, K.; Florindo, H.F.; et al. "Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs". Nanomedicine 12 21 (2017): 2581-2596. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032441481&partnerID=MN8TOARS.
    10.2217/nnm-2017-0219
  36. Santos, F.M.F.; Matos, A.I.; Ventura, A.E.; Gonçalves, J.; Veiros, L.F.; Florindo, H.F.; Gois, P.M.P.. "Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates". Angewandte Chemie - International Edition 56 32 (2017): 9346-9350. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022198030&partnerID=MN8TOARS.
    10.1002/anie.201703492
  37. Peres, C.; Matos, A.I.; Conniot, J.; Sainz, V.; Zupancic, E.; Silva, J.M.; Graça, L.; et al. "Poly(lactic acid)-based particulate systems are promising tools for immune modulation". Acta Biomaterialia 48 (2017): 41-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006324780&partnerID=MN8TOARS.
    10.1016/j.actbio.2016.11.012
  38. Martinho, N.; Silva, L.C.; Florindo, H.F.; Brocchini, S.; Barata, T.; Zloh, M.. "Practical computational toolkits for dendrimers and dendrons structure design". Journal of Computer-Aided Molecular Design 31 9 (2017): 817-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029512089&partnerID=MN8TOARS.
    10.1007/s10822-017-0041-6
  39. Silva, A.L.; Peres, C.; Conniot, J.; Matos, A.I.; Moura, L.; Carreira, B.; Sainz, V.; et al. "Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation". Seminars in Immunology 34 (2017): 3-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029574170&partnerID=MN8TOARS.
    10.1016/j.smim.2017.09.003
  40. Martinho, N.; Silva, L.C.; Florindo, H.F.; Brocchini, S.; Zloh, M.; Barata, T.S.. "Rational design of novel, fluorescent, tagged glutamic acid dendrimers with different terminal groups and in silico analysis of their properties". International Journal of Nanomedicine 12 (2017): 7053-7073. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030233633&partnerID=MN8TOARS.
    10.2147/IJN.S135475
  41. Santos, F.M.F.; Rosa, J.N.; Candeias, N.R.; Carvalho, C.P.; Matos, A.I.; Ventura, A.E.; Florindo, H.F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 44 (2016): 1631-1637. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950262633&partnerID=MN8TOARS.
    10.1002/chem.201504857
  42. Moura, L.; Martinho, N.; Barata, T.; Florindo, H.; Zloh, M.. "Computational design of a novel poly-glutamic dendrimer-based platform as an anticancer therapeutic approach". Febs Journal 283 (2016): 231-232. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000383616901326&KeyUID=WOS:000383616901326.
  43. Peres, C.; Matos, A. I.; Viana, A. S.; Graca, L.; Preat, V.; Florindo, H. F.. "Nanoparticle-based cancer vaccine to target dendritic cells and the tumor microenvironment". Febs Journal 283 (2016): 36-37. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000383616900112&KeyUID=WOS:000383616900112.
  44. Sainz, V.; Peres, C.; Ciman, T.; Rodrigues, C.; Viana, A. S.; Afonso, C. A. M.; Barata, T.; et al. "Optimization of protein loaded PLGA nanoparticle manufacturing parameters following a quality-by-design approach". Rsc Advances 6 106 (2016): 104502-104512. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000388111900076&KeyUID=WOS:000388111900076.
    10.1039/c6ra19092h
  45. Mograo, J.; Da Costa, C.A.; Gaspar, R.; Florindo, H.F.. "Modulation of dendritic cells by nanotechnology-based immunotherapeutic strategies". Journal of Biomedical Nanotechnology 12 3 (2016): 405-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959324169&partnerID=MN8TOARS.
    10.1166/jbn.2016.2157
  46. Zupancic, E.; Peres, C.; Matos, A.I.; Lopes, J.; Moreira, J.N.; Gaspar, R.S.; Florindo, H.F.; et al. "Translational peptide-associated nanosystems: Promising role as cancer vaccines". Current Topics in Medicinal Chemistry 16 3 (2016): 291-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974644157&partnerID=MN8TOARS.
    10.2174/1568026615666150701115508
  47. Rafael D; Doktorovová S; Florindo HF; Gener P; Abasolo I; Schwartz S; Videira MA. "EMT Blockage Strategies: Targeting Akt Dependent Mechanisms for Breast Cancer Metastatic Behaviour Modulation.". (2015): http://europepmc.org/abstract/med/25619882.
  48. Sainz, V.; Conniot, J.; Matos, A.I.; Peres, C.; Zupancic, E.; Moura, L.; Silva, L.C.; Florindo, H.F.; Gaspar, R.S.. "Regulatory aspects on nanomedicines". Biochemical and Biophysical Research Communications 468 3 (2015): 504-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951569805&partnerID=MN8TOARS.
    10.1016/j.bbrc.2015.08.023
  49. Silva, J.M.; Zupancic, E.; Vandermeulen, G.; Oliveira, V.G.; Salgado, A.; Videira, M.; Gaspar, M.; et al. "In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model". Journal of Controlled Release 198 (2015): 91-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918557500&partnerID=MN8TOARS.
    10.1016/j.jconrel.2014.11.033
  50. Rafael, D.; Doktorovová, S.; Florindo, H.F.; Gener, P.; Abasolo, I.; Schwartz, S.; Videira, M.A.. "EMT blockage strategies: Targeting Akt dependent mechanisms for breast cancer metastatic behaviour modulation". Current Gene Therapy 15 3 (2015): 300-312. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928941602&partnerID=MN8TOARS.
  51. Couto, A.S.; Vieira, J.; Florindo, H.F.; Videira, M.A.; Cabral-Marques, H.M.. "Characterisation of DM-ß-cyclodextrin: Prednisolone complexes and their formulation as eye drops". Journal of Inclusion Phenomena and Macrocyclic Chemistry 80 1-2 (2014): 155-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922418658&partnerID=MN8TOARS.
    10.1007/s10847-014-0420-8
  52. Martinho N; Florindo H; Silva L; Brocchini S; Zloh M; Barata T. "Molecular Modeling to Study Dendrimers for Biomedical Applications.". (2014): http://europepmc.org/abstract/med/25493631.
  53. Silva, J.M.; Vandermeulen, G.; Oliveira, V.G.; Pinto, S.N.; Rodrigues, C.; Salgado, A.; Afonso, C.A.; et al. "Development of functionalized nanoparticles for vaccine delivery to dendritic cells: A mechanistic approach". Nanomedicine 9 17 (2014): 2639-2656. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919788438&partnerID=MN8TOARS.
    10.2217/nnm.14.135
  54. Martinho, N.; Florindo, H.; Silva, L.; Brocchini, S.; Zloh, M.; Barata, T.. "Molecular modeling to study dendrimers for biomedical applications". Molecules 19 12 (2014): 20424-20467. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919742776&partnerID=MN8TOARS.
    10.3390/molecules191220424
  55. Conniot J; Silva JM; Fernandes JG; Silva LC; Gaspar R; Brocchini S; Florindo HF; Barata TS. "Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking.". (2014): http://europepmc.org/abstract/med/25505783.
    10.3389/fchem.2014.00105
  56. Silva, J.M.; Videira, M.; Gaspar, R.; Préat, V.; Florindo, H.F.. "Immune system targeting by biodegradable nanoparticles for cancer vaccines". Journal of Controlled Release 168 2 (2013): 179-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877945468&partnerID=MN8TOARS.
    10.1016/j.jconrel.2013.03.010
  57. Rodrigues, M.A.; Figueiredo, L.; Padrela, L.; Cadete, A.; Tiago, J.; Matos, H.A.; Azevedo, E.G.D.; et al. "Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model". European Journal of Pharmaceutics and Biopharmaceutics 82 2 (2012): 392-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867877552&partnerID=MN8TOARS.
    10.1016/j.ejpb.2012.07.005
  58. Bettencourt, A.; Florindo, H.F.; Ferreira, I.F.S.; Matos, A.; Monteiro, J.; Neves, C.; Lopes, P.; et al. "Incorporation of tocopherol acetate-containing particles in acrylic bone cement". Journal of Microencapsulation 27 6 (2010): 533-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955433425&partnerID=MN8TOARS.
    10.3109/02652048.2010.484106
  59. Florindo, H.F.; Pandit, S.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "Surface modified polymeric nanoparticles for immunisation against equine strangles". International Journal of Pharmaceutics 390 1 (2010): 25-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951255224&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2009.10.009
  60. Florindo, H.F.; Pandit, S.; Lacerda, L.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "The enhancement of the immune response against S. equi antigens through the intranasal administration of poly-e-caprolactone-based nanoparticles". Biomaterials 30 5 (2009): 879-891. http://www.scopus.com/inward/record.url?eid=2-s2.0-57549114032&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2008.10.035
  61. Florindo, H.F.; Pandit, S.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "New approach on the development of a mucosal vaccine against strangles: Systemic and mucosal immune responses in a mouse model". Vaccine 27 8 (2009): 1230-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749108436&partnerID=MN8TOARS.
    10.1016/j.vaccine.2008.12.004
  62. Florindo, H.F.; Pandit, S.; Gonçalves, L.M.D.; Alpar, H.O.; Almeida, A.J.. "Streptococcus equi antigens adsorbed onto surface modified poly-e-caprolactone microspheres induce humoral and cellular specific immune responses". Vaccine 26 33 (2008): 4168-4177. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149110539&partnerID=MN8TOARS.
    10.1016/j.vaccine.2008.05.074
Preprint
  1. Kumar S; Basto AP; Ribeiro F; Almeida SCP; Campos P; Peres C; Al-Khalidi S; et al. "Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue". 2022. http://europepmc.org/abstract/PPR/PPR525995.
    10.1101/2022.07.28.501817
Thesis / Dissertation
  1. Florindo, Helena Isabel Fialho, 1979-. "Development of alternative micro and nanoparticulate polymeric systems for mucosal delivery of Streptococcus equi antigens". PhD, 2008. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000542728.

Intellectual property

Provisional application for patent
  1. 2019. "Polymeric Nanovaccines and used thereof".
    Protected

Other

Other output
  1. Antibody and cytokine-associated immune responses to S. equi antigens entrapped in PLA nanospheres. Strangles is an infectious disease caused by Streptococcus equi subspecies equi that affects the upper respiratory tract of the Equidae. The control of this disease seems to be dependent on its earlier detection and prevention, but prolonged animal protection without development of strong and severe side effects has not yet been achieved. Convalescent horses exhibit a protective immune response, m. 2009. Florindo, Helena F.; Pandit, Sreenivas; Goncalves, Lidia M. D.; Videira, Mafalda; Alpar, Oya; Almeida, Antonio J.; Florindo, H.F.; et al. http://hdl.handle.net/10451/20980.
    http://dx.doi.org/10.1016/j.biomaterials.2009.05.045
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2020/02/01 - Current Viral Envelopes Coating HPMA-Selenium Nanoparticles for Cancer Targeting Therapy
Supervisor of Cláudio Ferro
PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/12 - Current Alteração da estratégia de controlo de qualidade de medicamentos para real-time release
Supervisor of Tânia Freire
M.Sc. in Pharmaceutical Engineering (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/01 - Current Using co-creation to identify technology-based solutions to improve medication adherence against breast cancer
Co-supervisor of Catarina Bernardo
PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Current Small molecules for cancer immunotherapy: A melanoma approach
Supervisor of Lara Serronha
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Current Combination immunotherapy against Pancreatic Cancer
Supervisor of Inês Vilar
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Current Nano-delivery approach for targeting type 1 collagen in breast cancer microenvironment
Supervisor of Mafalda Verdial
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - Current Nano-vaccine combined with nano-based delivery of siRNA targeting GLUT-1 and miRNA-143 for the treatment of colorectal cancer
Supervisor of Raquel Coelho
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/12/01 - Current Modulation of tumor microenvironment using nanovaccine
Supervisor of Madalena Alves
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2020/04/30 COMBI_CRC: Combinatorial multivalent nanoplatform for colorectal cancer treatment
Supervisor of Ana Isabel Neves de Matos
Engenharia Biomédica (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/09/01 - 2019/12/12 Multifunctional nano-vaccines against melanoma
Supervisor of Ana Filipa Gonçalves
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/01 - 2019/12/01 Impact of the Modulation of Tumor Vasculature on Cancer Vaccine Efficacy
Supervisor of Sandra Pena
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/01 - 2019/12/01 Combinational vaccines against colorectal cancer
Supervisor of Mariana Mateus
M.Sc. in BioPharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2019/12 Discovery and Development of Novel Small-Molecule Immune System Modulators
Co-supervisor of Ana Rita de Carvalho Acúrcio
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2019 Multistage pancreas biomimetic construct based on synergism of functionalized nanomedicines and cell differentiation
Co-supervisor of Joana Beatriz Antunes Moreira Carvalho Marques
Ciências Farmacêuticas (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/09/01 - 2016/01/05 Biomembranes as barrier for therapeutic entities
Co-supervisor of Melissa Sirage
M.Sc. in Biomedical Engineering (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2015 Multicomponent Particulates for Immune Modulation
Supervisor of João Miguel de Oliveira Conniot
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09/01 - 2014/12/01 Development of nanosystems for HIV vaccine delivery
Co-supervisor of Ana Isabel Matos
M.Sc. in Biochemistry (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2014 Development of a Melanoma Therapeutic Vaccine Candidate by the Coencapsulation of Melanoma Antigen Peptides and Toll-like Receptor Ligands as Adjuvants into Polymeric Nanoparticles
Supervisor of Joana Catarina Mendão Azeitão da Silva
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Intracellularly-targeted nanoplatform to target dendritic cells and for immunomodulation
Supervisor of Carina Sofia Gonçalves Peres
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Anti-tumor immunity induced by a novel nanoparticulate vaccine: a mechanism approach
Supervisor of Eva Zupancic
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Hybrid lipid-polymeric nanoplatform as cancer immunotherapeutics
Supervisor of Vanessa Gameiro Sainz
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 AKT2 siRNA-nanoparticulate system as a new tool to restoration of E-cadherin and eradicate tumour metastic phenotype
Co-supervisor of Diana Fernandes de Sousa Rafael
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Committee member

Activity description
Role
Institution / Organization
2023/08/28 - Current Scientific council member
Member
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/02/01 - Current Executive Board Member
Member
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2020/02/01 - Current Executive Board Member
Member
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Conference scientific committee

Conference name Conference host
2021/10/15 - 2021/10/15 Cutaneous Melanoma: from where to where? Liga Portuguesa COntra o Cancro

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2016/12/01 - Current Clinical Expert (Pharmacokinetics and Biodistribution) involved in the evalauation of Common Technical Documents related to the approval of Medicines
Evaluator
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/02/03 Interview regarding the developmento fo a COVID-19 vaccine Público newspaper
2020/09/21 Interview to Jornal Observador related to the COVID-19 project awarded by La CAixa FOundation
2019/08/06 News regarding the publication of the Nature Nanotechnology paper on the development of our cancer nano-vaccine against melanoma
2019/08/06 On the RTP journal news on the development of our cancer nano-vaccine, following the publication of our results on Nature Nanotechnology paper RTP News national journal (afternoon and night emission)
2019/08/06 Several news published worldwide regarding our nano-vaccine against melanoma Several news in several countries: israel, USA etc..

Interview (tv / radio show)

Program Topic
2021/02/24 - Current The Old Friends - Antena 1 COVID-19
2020/04/28 - Current Programa Sociedade Civil -RTP2 Cancer nanovaccine research to fight melanoma
2019/08/06 - Current News emission on TVI national agency - News on the development of our cancer nano-vaccine, following the publication of our results on Nature Nanotechnology paper Cancer Vaccine against melanoma
2019/08/05 - Current RTP 3 Nanovaccine against melanoma
2019/08/05 - Current News on the development of our cancer nano-vaccine, following the publication of our results on Nature Nanotechnology paper RTP
Distinctions

Award

2020 Young Investigator Immunology
Controlled Release Society - Nanomedicine and Nanoscale Delivery Focus Group , United States
2015 Gene therapy for HIV cure: two complementary strategies delivered by self-amplifying RNA vectors
2014 COMBI-VIH: multivalent nanoplatform for immunomodulation to control HIV infection.
Gilead Program Award , Portugal

Other distinction

2019 Scientific achievements featured in the national and international press
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Young Scientist Award for the best oral communication award
2015 Best Poster award
2013 Best poster award
2013 Best oral communication
2013 Best poster award
2011 Best Oral commmunication award
2009 Grant awarded to participate in the “2nd ESF/UB European Summer School on Nanomedicine”, Lisboa, Portugal (2009).
2007 Research activity mentioned in the international press: McCluskey, M (2007). New vaccine technology. Equus Magazine, 352 (January): 10.
2006 Best Oral commmunication award
2005 Nomination for Controlled Release Society's Outstanding Veterinary Paper Award