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- Maria C. Pedroso de Lima (h-factor 48, Scopus) received her Ph.D. degree in Chemistry from Imperial College of Science and Technology at the University of London and her Habilitation (Agregação) degree in Biochemistry from the University of Coimbra. - She is Full Professor and Leader of the Group "Therapies Targeting Brain Diseases: Genomic and Lipidomic Approaches" at the Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. - Her research activity has been centred on the development of novel functionalized nanosystems for targeted delivery of different types of therapeutic molecules (including drugs, plasmid DNA, antisense oligonucleotides, siRNAs and miRNAs) into specific tissues /cells and of innovative molecular therapeutic strategies, which have been evaluated both in cell and animal models of cancer and neurodegenerative disorders, towards their clinical application. Investigation of the mechanisms underlying the process of drug/nucleic acid delivery and the molecular/cellular events associated with the therapeutic response constitutes an important focus of her research activity. She is currently working on a project addressing the role of cancer stem-like cells (CSCs) in glioblastoma (GBM) progression and recurrence, and identification of new molecular targets involved in the renewal and differentiation of GSCs. The primary aim is to fight GBM through modulation of the activity of key miRNAs that control GBM molecular pathogenesis, particularly dysregulated miRNAs that are implicated in the mechanisms of GSCs-associated drug resistance, as a therapeutic strategy to be combined with new-generation chemotherapy. - She published over 180 full papers in international peer-reviewed journals and 33 international scientific book chapters, with more than 7250 citations (Scopus). - She has authored over 300 communications presented in scientific meetings. - She holds 5 patents on non-viral drug/gene delivery and gene therapy, 4 of which approved in USA. - She has edited/co-edited 2 books, one (Editor) published by Springer-Verlag and the other (Co-Editor) published by Translational Research Network. - She is a reviewer for over 25 international scientific journals. - She was Chair and member of the Scientific Committee of national and international conferences in the fields of membrane fusion and gene therapy and was the Director of a NATO Advanced Study Institute on the trafficking of intracellular membranes and membrane fusion. - She has successfully supervised 4 post-doctoral researchers, 24 PhD students and over 20 Master students. - She received the international 2013 Exiqon award for a grant proposal on the development and application of a targeted nanosystem for systemic delivery in a miRNA-based therapy towards glioblastoma. - She has served as evaluator of research proposals, both for the European Union and national governments (England, Israel, Poland and Portugal). - She has been responsible for national and international research projects funded by the NATO Scientific Affairs Division, European Union, CRUP and the Portuguese Foundation for Science and Technology (FCT).
Identificação

Identificação pessoal

Nome completo
Maria da Conceição Monteiro Pedroso de Lima

Nomes de citação

  • Lima, Maria
  • Maria C. Pedroso de Lima
  • Maria Pedroso de Lima

Identificadores de autor

Ciência ID
A11E-4930-EEEA
ORCID iD
0000-0003-1844-5027
Scopus Author Id
7004364781

Endereços de correio eletrónico

  • mdelima@ci.uc.pt (Profissional)
  • mdelima@cnc.uc.pt (Profissional)

Telefones

Telefone
  • 239820190 (Profissional)

Moradas

  • Universidade de Coimbra . Centro de Neurociências e Biologia Celular, Largo Marquês de Pombal, Universidade de Coimbra. Coimbra, 3004-517, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • http://www.cnbc.pt/research/department_show.asp?iddep=1221 (Profissional)
  • http://www.cnbc.pt/research/departments.asp (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
1997
Concluído
Biochemistry (Título de Agregado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A hemaglutinina do vírus Influenza: Uma proteína modelo no estudo dos mecanismos de fusão membranar " (TESE/DISSERTAÇÃO)
Aprovação por unanimidade
1977/03
Concluído
Chemistry (Doctor of Philosophy)
Especialização em Chemistry
Imperial College of Science and Technology, University of London , Reino Unido
"Transference number studies by the direct moving boundary method" (TESE/DISSERTAÇÃO)
Approved with greatest honors
1972
Concluído
Química (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"." (TESE/DISSERTAÇÃO)
Distinção
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2003 - Atual Investigador principal (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
1998 - Atual Professor Catedrático (Docente Universitário) Universidade de Coimbra, Faculdade de Ciências , Portugal
1981 - 1998 Professor Associado (Docente Universitário) Universidade de Coimbra, Faculdade de Ciências , Portugal
1988 - 1990 Professor Visitante (Docente Universitário) University of California San Francisco Medical Center at Parnassus, Estados Unidos
University of California San Francisco Medical Center at Parnassus, Estados Unidos
1983 - 1984 Professor Visitante (Docente Universitário) University of California Berkeley Department of Chemistry, Estados Unidos
University of California Berkeley, Estados Unidos
1977 - 1981 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Faculdade de Ciências , Portugal
1973 - 1977 Assistente (Docente Universitário) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2006 - 2008 Presidente de Unidade Orgânica Department of Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal
Department of Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal
1997 - 1999 Presidente de Unidade Orgânica Department of Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal
Department of Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2017 - 2021 Tackling Cancer Stem Cells: A Challenge and an Opportunity to Advance in Anti-Cancer Therapy
FCT-POCI-01-0145-FEDER-016390
Investigador
Fundação para a Ciência e a Tecnologia
2018 - 2020 Thioredoxin Arrest to Reduce Glioblastoma: Ethylmercury and Thimerosal to target CANCER
C490709752-00081714
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2017 - 2020 BrainHealth2020- Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders
CENTRO-01-0145-FEDER-000008
Investigador
Comissão de Coordenação e Desenvolvimento Regional do Centro
2016 - 2018/12 A Lipidomic and MiRNA-Based Strategy for GlioblastomaTtreatment
A03/2016
Investigador responsável
CRUP/DAAD
2013 - 2015/08 Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
Provided by PTCRIS: 125208
Investigador
Fundação para a Ciência e a Tecnologia
2013 - 2015/03 Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
Provided by PTCRIS: 124488
124488
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2012/02 Suicide gene therapy in cancer stem cells from solid tumors: towards a new antitumoral strategy
No reference code Proc 441.00
Investigador responsável
Fundação para a Ciência e a Tecnologia
2009 - 2011/12 Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)
109361
Provided by PTCRIS: 109361
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2009 - 2011 Interaction of Lipoplexes with Cellular Membranes: a Biophysical Approach to Gene Delivery
PTDC/QUI-BIQ/103001/2008
Investigador
Fundação para a Ciência e a Tecnologia
2007 - 2010/12 Silencing Machado-Joseph disease: lentiviral-mediated RNA interference to ataxin-3
Provided by PTCRIS: 70384
Investigador
Fundação para a Ciência e a Tecnologia
2007 - 2010/12 Development of novel approaches for anti-tumor therapy based on the S4(13)-PV cell penetrating peptide to improve the intracellular delivery of therapeutic nucleic acids and proteins
Provided by PTCRIS: 65627
65627
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2008/08 Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs
Provided by PTCRIS: 56055
Investigador
Fundação para a Ciência e a Tecnologia
2005 - 2008/02 Targeted drug delivery to tumor vasculature: a new therapy against human breast cancer.
Provided by PTCRIS: 57831
Investigador
Fundação para a Ciência e a Tecnologia
2004 - 2007/11 Mechanisms of nucleo-cytoplasmic trafficking of ASFV genome and design of anti-NLS/NES backbone cyclic peptides to block viral infection
Provided by PTCRIS: 44854
44854
Investigador responsável
Fundação para a Ciência e a Tecnologia
2003 - 2006 Targeted antisense therapy: a novel approach for the treatment of human small cell lung cancer
POCTI/FCB/48487/2002
Investigador
Fundação para a Ciência e a Tecnologia
2003 - 2006 Targeted Contrast Agents for Magnetic Resonance Imaging (MRI) and Nuclear Scintigraphy
(TARCAS) POCTI/QUI/47005/2002
Investigador
Fundação para a Ciência e a Tecnologia
2003 - 2005/12 Mechanisms of nucleo-cytoplasmic trafficking of ASFV genome and design of anti-NLS/NES backbone cyclic peptides to prevent viral infection
Provided by PTCRIS: 42700
42700
Investigador responsável
Fundação para a Ciência e a Tecnologia
2001 - 2004 Targeting of genes and antisense oligonucleotides by novel liposome formulations: evaluation of their therapeutic efficacy in human leukaemia.
FCT/BIO/36202/99
Investigador
Fundação para a Ciência e a Tecnologia
2000 - 2002 Strategies to Enhance Gene Delivery: Overcoming the Nuclear Barrier
No reference code
Investigador responsável
NATO Scientific Affairs Division
1997 - 2000/09 Non-Viral Gene Transfer Vectors.
EC BIO4-CT97-2191
Investigador responsável
European Commission
1997 - 2000 Transport and delivery of genes and oligonucleotides mediated by liposomes: Mechanisms of internalization and design of novel formulations
PRAXIS/ PCNA/P/BIO/45/ 96
Investigador responsável
Fundação para a Ciência e a Tecnologia
1993 - 1998 Mechanisms of genetic variability and immunoresistance to African Swine Fever Virus
PBIC/P/AGR/1824/93
Investigador responsável
Fundação para a Ciência e a Tecnologia
1993 - 1996 Mechanisms of fusion and uncoating of African Swine Fever virus: Initial stages of viral infection
STRDA/C/AGR/191/92
Investigador responsável
Fundação para a Ciência e a Tecnologia
1990 - 1994 Fusion Activity of lipid enveloped viruses
CRG.900333
Investigador responsável
NATO Scientific Affairs Division
1990 - 1993/09/01 Membrane fusion : Mechanisms of viral infection and intracelular membrane fusion
PMCT/C/BIO/214/90
Investigador responsável
Center for Cell Biology , University of Coimbra , Portugal
1986 - 1987/09 Calorimetric and Thermodynamic Study of the Interaction of Calcium Channel Blockers and of Dopamine Agonists and Antagonists with Liposomes and Biological Membranes
no reference
Investigador responsável

Outro

Designação Financiadores
1986 - 1987/09 Determination of Thermodynamic Parameters in Biomembranes
no reference code
Investigador responsável
Fundação Calouste Gulbenkian
Produções

Publicações

Artigo em boletim informativo
  1. Maria C. Pedroso de Lima. "Peptide Therapeutics in Portugal", The European Peptide Society , 2018
Artigo em conferência
  1. Maria C. Pedroso de Lima. "Insights into the mechanisms involved in the cellular uptake of the S413-PV karyophilic cell penetrating peptide". Trabalho apresentado em 3rd International and 28th European Peptide Symposium, 2005.
    Publicado • 10.1109/nebc.2010.5458127
  2. Sharkovsky, A.N.; Berezovsky, S.A.. "Thermodynamics of phase transitions in some organic polyols.". Trabalho apresentado em 4th International Conference on Chemical Engineering, 1985.
    10.1109/coc.2000.873496
  3. de Lima, M.C.P.; Maycock, C.D.. "LOW TEMPERATURE THERMAL ENERGY STORAGE USING SOLID-STATE PHASE CHANGE MATERIALS.". Trabalho apresentado em Energy Economics and Management in Industry, Oxford, 1984.
    Publicado
Artigo em revista
  1. Cardoso, Ana M; Morais, Catarina M; Sousa, Madalena; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S. "MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance". Human Molecular Genetics (2021): http://dx.doi.org/10.1093/hmg/ddab193.
    10.1093/hmg/ddab193
  2. Ana Cardoso, Catarina M Morais, Frederico Pena, Tânia Marante, Pedro Cunha, Amália S Jurado, Maria C Pedroso de Lima. "Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib". Human Molecular Genetics 30 (2021): 160-171.
    Acesso aberto • doi: 10.1093/hmg/ddab011.
  3. Cardoso, Ana M; Morais, Catarina M; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S. "Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through an miR-302a-dependent mechanism". Human Molecular Genetics 30 1 (2021): 46-64. http://dx.doi.org/10.1093/hmg/ddab009.
    10.1093/hmg/ddab009
  4. Pereira, S.P.; Santos, S.M.A.; Fernandes, M.A.S.; Deus, C.M.; Martins, J.D.; Pedroso de Lima, M.C.; Vicente, J.A.F.; Videira, R.A.; Jurado, A.S.. "Improving pollutants environmental risk assessment using a multi model toxicity determination with in vitro, bacterial, animal and plant model systems: The case of the herbicide alachlor". Environmental Pollution 286 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105603093&partnerID=MN8TOARS.
    10.1016/j.envpol.2021.117239
  5. Faria, Rúben; Albuquerque, Tânia; Neves, Ana R.; Bhatt, Himanshu; Biswas, Swati; Cardoso, Ana M.; Pedroso de Lima, Maria C.; Jurado, Amália S.; Costa, Diana. "Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes". Journal of Molecular Liquids 316 (2020): 113873. http://dx.doi.org/10.1016/j.molliq.2020.113873.
    10.1016/j.molliq.2020.113873
  6. Morais, Catarina M.; Cardoso, Ana M.; Aguiar, Luísa; Vale, Nuno; Nóbrega, Clévio; Zuzarte, Mónica; Gomes, Paula; Pedroso de Lima, Maria C.; Jurado, Amália S.. "Lauroylated Histidine-Enriched S413-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells". Pharmaceutical Research 37 10 (2020): 188. http://dx.doi.org/10.1007/s11095-020-02904-x.
    10.1007/s11095-020-02904-x
  7. Coutinho, Maria Francisca; Santos, Juliana Inês; S. Mendonça, Liliana; Matos, Liliana; Prata, Maria João; S. Jurado, Amália; Pedroso de Lima, Maria C.; Alves, Sandra. "Lysosomal Storage Disease-Associated Neuropathy: Targeting Stable Nucleic Acid Lipid Particle (SNALP)-Formulated siRNAs to the Brain as a Therapeutic Approach". International Journal of Molecular Sciences 21 16 (2020): 5732. http://dx.doi.org/10.3390/ijms21165732.
    10.3390/ijms21165732
  8. Morais, C.M.; Cunha, P.P.; Melo, T.; Cardoso, A.M.; Domingues, P.; Domingues, M.R.; Pedroso de Lima, M.C.; Jurado, A.S.. "Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma". Human Molecular Genetics 28 21 (2019): 3664-3679. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077223998&partnerID=MN8TOARS.
    10.1093/hmg/ddz152
  9. Cabral Filho, P.E.; Cabrera, M.P.; Cardoso, A.L.C.; Santana, O.A.; Geraldes, C.F.G.C.; Santos, B.S.; Pedroso de Lima, M.C.; Pereira, G.A.L.; Fontes, A.. "Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells". Biochimica et Biophysica Acta - General Subjects 1862 12 (2018): 2788-2796. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052949793&partnerID=MN8TOARS.
    10.1016/j.bbagen.2018.08.014
  10. Lebre, F.; Pedroso de Lima, M.C.; Lavelle, E.C.; Borges, O.. "Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles". International Journal of Pharmaceutics 552 1-2 (2018): 7-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053833190&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2018.09.044
  11. Morais, C.M.; Cardoso, A.M.; Cunha, P.P.; Aguiar, L.; Vale, N.; Lage, E.; Pinheiro, M.; et al. "Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions". Biochimica et Biophysica Acta - Biomembranes 1860 12 (2018): 2619-2634. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054439165&partnerID=MN8TOARS.
    10.1016/j.bbamem.2018.10.002
  12. Pedro P Cunha; Pedro M Costa; Catarina M Morais; Inês R Lopes; Ana M Cardoso; Ana L Cardoso; Miguel Mano; Amália S Jurado; Maria C Pedroso de Lima. "High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors". Human Molecular Genetics 26 22 (2017): 4375-4387. https://doi.org/10.1093/hmg/ddx323.
    10.1093/hmg/ddx323
  13. Marco Craveiro; Gaspard Cretenet; Cédric Mongellaz; Maria I. Matias; Olivier Caron; Maria C. Pedroso de Lima; Valérie S. Zimmermann; et al. "Resveratrol stimulates the metabolic reprogramming of human CD4+T cells to enhance effector function". Science Signaling 10 501 (2017): eaal3024-eaal3024. https://doi.org/10.1126/scisignal.aal3024.
    10.1126/scisignal.aal3024
  14. Lebre, F.; Bento, D.; Ribeiro, J.; Colaço, M.; Borchard, G.; Pedroso De Lima, M.C.P.; Borges, O.. "Association of chitosan and aluminium as a new adjuvant strategy for improved vaccination". International Journal of Pharmaceutics 527 1-2 (2017): 103-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019758926&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2017.05.028
  15. Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype". Biomaterials 82 (2016): 124-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956644943&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2015.12.021
  16. Cabral Filho, P.E.; Cardoso, A.L.C.; Pereira, M.I.A.; Ramos, A.P.M.; Hallwas, F.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; et al. "CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells". Biochimica et Biophysica Acta - General Subjects 1860 1 (2016): 28-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946430431&partnerID=MN8TOARS.
    10.1016/j.bbagen.2015.09.021
  17. Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief 6 (2016): 700-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS.
    10.1016/j.dib.2016.01.017
  18. Lebre, F.; Borchard, G.; Faneca, H.; Pedroso De Lima, M.C.; Borges, O.. "Intranasal Administration of Novel Chitosan Nanoparticle/DNA Complexes Induces Antibody Response to Hepatitis B Surface Antigen in Mice". Molecular Pharmaceutics 13 2 (2016): 472-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957308940&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.5b00707
  19. Cardoso, A.L.; Guedes, J.R.; De Lima, M.C.P.. "Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions". Current Opinion in Pharmacology 26 (2016): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942921906&partnerID=MN8TOARS.
    10.1016/j.coph.2015.09.001
  20. Cruz, R.Q.; Morais, C.M.; Cardoso, A.M.; Silva, S.G.; Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes". European Journal of Pharmaceutics and Biopharmaceutics 104 (2016): 7-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964330230&partnerID=MN8TOARS.
    10.1016/j.ejpb.2016.04.014
  21. Guedes, J.R.; Santana, I.; Cunha, C.; Duro, D.; Almeida, M.R.; Cardoso, A.M.; de Lima, M.C.P.; Cardoso, A.L.. "MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease". Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 3 (2016): 7-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956620147&partnerID=MN8TOARS.
    10.1016/j.dadm.2015.11.004
  22. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S.. "New serine-derived gemini surfactants as gene delivery systems". European Journal of Pharmaceutics and Biopharmaceutics 89 (2015): 347-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920830778&partnerID=MN8TOARS.
    10.1016/j.ejpb.2014.12.013
  23. Costa, P.M.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P.. "MicroRNAs in glioblastoma: Role in pathogenesis and opportunities for targeted therapies". CNS and Neurological Disorders - Drug Targets 14 2 (2015): 222-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930907378&partnerID=MN8TOARS.
    10.2174/1871527314666150116123610
  24. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression". Molecular Pharmaceutics 12 3 (2015): 716-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS.
    10.1021/mp5005349
  25. Costa, P.M.; Cardoso, A.L.; Custódia, C.; Cunha, P.; Pereira De Almeida, L.; Pedroso De Lima, M.C.. "MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma". Journal of Controlled Release 207 (2015): 31-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926665383&partnerID=MN8TOARS.
    10.1016/j.jconrel.2015.04.002
  26. Maria C. Pedroso de Lima. "Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model.". Human Molecular Genetics (2014): http://www.ncbi.nlm.nih.gov/pubmed/24990149.
    10.1093/hmg/ddu348
  27. Henrique Faneca; Marta Passadouro; Maria Pedroso de Lima. "MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer". International Journal of Nanomedicine (2014): 3203-3203. https://doi.org/10.2147%2Fijn.s64456.
    10.2147/ijn.s64456
  28. Kjøniksen, A.-L.; Calejo, M.T.; Zhu, K.; Cardoso, A.M.S.; De Lima, M.C.P.; Jurado, A.S.; Nyström, B.; Sande, S.A.. "Sustained release of naltrexone from Poly(N-Isopropylacrylamide) microgels". Journal of Pharmaceutical Sciences 103 1 (2014): 227-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890551451&partnerID=MN8TOARS.
    10.1002/jps.23780
  29. Cardoso, A.M.; Morais, C.M.; Silva, S.G.; Marques, E.F.; De Lima, M.C.P.; Jurado, M.A.S.. "Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions". International Journal of Pharmaceutics 474 1-2 (2014): 57-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906267891&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.08.011
  30. Magalhães, M.; Farinha, D.; de Lima, M.C.P.; Faneca, H.. "Increased gene delivery efficiency and specificity of a lipid-based nanosystem incorporating a glycolipid". International Journal of Nanomedicine 9 (2014): 4979-4989. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930260157&partnerID=MN8TOARS.
    10.2147/IJN.S69822
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  91. Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C.. "siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing". Journal of Gene Medicine 9 3 (2007): 170-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047102911&partnerID=MN8TOARS.
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  93. Bertin, S.; Neves, S.; Gavelli, A.; Baqué, P.; Brossette, N.; Simões, S.; Pedroso De Lima, M.C.; Pierrefite-Carle, V.. "Cellular and molecular events associated with the antitumor response induced by the cytosine deaminase/5-fluorocytosine suicide gene therapy system in a rat liver metastasis model". Cancer Gene Therapy 14 10 (2007): 858-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548606960&partnerID=MN8TOARS.
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  95. Mano, M.; Henriques, A.; Paiva, A.; Prieto, M.; Gavilanes, F.; Simões, S.; Pedroso de Lima, M.C.. "Cellular uptake of S413-PV peptide occurs upon conformational changes induced by peptide-membrane interactions". Biochimica et Biophysica Acta - Biomembranes 1758 3 (2006): 336-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646534241&partnerID=MN8TOARS.
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  101. Fonseca, C.; Moreira, J.N.; Ciudad, C.J.; Pedroso De Lima, M.C.; Simões, S.. "Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells". European Journal of Pharmaceutics and Biopharmaceutics 59 2 (2005): 359-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344294490&partnerID=MN8TOARS.
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  102. Girão da Cruz, M.T.; Cardoso, A.L.C.; de Almeida, L.P.; Simões, S.; Pedroso de Lima, M.C.. "Tf-lipoplex-mediated NGF gene transfer to the CNS: Neuronal protection and recovery in an excitotoxic model of brain injury". Gene Therapy 12 16 (2005): 1242-1252. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944465946&partnerID=MN8TOARS.
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  103. Teixeira, L.J.; Seabra, M.; Reis, E.; Da Cruz, M.T.G.; De Lima, M.C.P.; Pereira, E.; Miranda, M.A.; Marques, M.P.M.. "Cytotoxic activity of metal complexes of biogenic polyamines: Polynuclear platinum(II) chelates". Journal of Medicinal Chemistry 47 11 (2004): 2917-2925. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542477134&partnerID=MN8TOARS.
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  105. Piedade, J.A.P.; Mano, M.; Pedroso De Lima, M.C.; Oretskaya, T.S.; Oliveira-Brett, A.M.. "Electrochemical sensing of the behaviour of oligonucleotide lipoplexes at charged interfaces". Biosensors and Bioelectronics 20 5 (2004): 975-984. http://www.scopus.com/inward/record.url?eid=2-s2.0-7644240649&partnerID=MN8TOARS.
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  109. Piedade, J.A.P.; Mano, M.; Pedroso de Lima, M.C.; Oretskaya, T.S.; Oliveira-Brett, A.M.. "Voltammetric behaviour of oligonucleotide lipoplexes adsorbed onto glassy carbon electrodes". Journal of Electroanalytical Chemistry 564 1-2 (2004): 25-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342285697&partnerID=MN8TOARS.
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  147. Da Silva, C.P.; De Oliveira, C.R.; De Lima, M.D.C.P.. "Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes". Biochemical Pharmacology 51 10 (1996): 1331-1340. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029947269&partnerID=MN8TOARS.
    10.1016/0006-2952(96)00041-X
  148. Ramalho-Santos, J.; De Pedroso Lima, M.C.; Nir, S.. "Partial fusion activity of influenza virus toward liposomes and erythrocyte ghosts is distinct from viral inactivation". Journal of Biological Chemistry 271 39 (1996): 23902-23906. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029842067&partnerID=MN8TOARS.
    10.1074/jbc.271.39.23902
  149. Alpoim, M.C.; Geraldes, C.F.; Oliveira, C.R.; Lima, M.C.. "Molecular mechanisms of chromium toxicity oxidation of hemoglobin". Biochemical Society Transactions 23 2 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029010431&partnerID=MN8TOARS.
  150. Zachariah, C.; Defreitas, D.M.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; Lima, M.C.P.; Oliveira, C.R.. "The Use of Microcarrier Beads in Ion Transport NMR Studies of Perfused Cells". Journal of Magnetic Resonance, Series B 108 1 (1995): 81-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029336712&partnerID=MN8TOARS.
    10.1006/jmrb.1995.1106
  151. Bernardes, C.; Valdeira, M.L.; Ramalho-Santos, J.; De Lima, M.C.P.. "Fusion activity of African swine fever virus towards target membranes: Lipid dependence and effect of dehydrating agents". Biochemistry and Molecular Biology International 37 3 (1995): 481-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029555561&partnerID=MN8TOARS.
  152. Pedroso de Lima, M.C.; Ramalho-Santos, J.; Flasher, D.; Slepushkin, V.A.; Nir, S.; Düzgunes, N.. "Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus". BBA - Biomembranes 1236 2 (1995): 323-330. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029026187&partnerID=MN8TOARS.
    10.1016/0005-2736(95)00067-D
  153. Aureliano, M.; Pedroso, M.C.; De Lima; Carvalho, A.P.; Pires, E.M.V.. "Effect of myosin phosphorylation on actomyosin ATPase activity: a flow microcalorimetric study". Thermochimica Acta 258 C (1995): 59-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243321608&partnerID=MN8TOARS.
    10.1016/0040-6031(94)02192-Q
  154. Ramalho-Santos, J.; Negrao, R.; Da Conceicao Pedroso de Lima, M.. "Fusion of Sendai virus with model membranes as affected by dehydrating agents and pH: Correlation between viral envelope hydrophobicity and fusion activity". Biochemistry and Molecular Biology International 32 6 (1994): 1121-1127. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028352917&partnerID=MN8TOARS.
  155. Ramalho-Santos, J.; Negrão, R.; Lima, M.d.C.P.d.. "Role of hydrophobic interactions in the fusion activity of influenza and sendai viruses towards model membranes". Bioscience Reports 14 1 (1994): 15-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028243606&partnerID=MN8TOARS.
    10.1007/BF01901634
  156. da Silva, C.P.; de Oliveira, C.R.; de Lima, M.d.C.P.. "In vitro assay of the effects of anticancer drugs on leukemic T-cells by flow microcalorimetry". International Journal of Pharmaceutics 111 1 (1994): 25-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028067072&partnerID=MN8TOARS.
    10.1016/0378-5173(94)90398-0
  157. Almeida, M.T.; Ramalho-Santos, J.; Oliveira, C.R.; Pedroso de Lima, M.C.. "Parameters affecting fusion between liposomes and synaptosomes. Role of proteins, lipid peroxidation, pH and temperature". The Journal of Membrane Biology 142 2 (1994): 217-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027993101&partnerID=MN8TOARS.
    10.1007/BF00234943
  158. Ramalho-Santos, J.; Nir, S.; Düzgünes, N.; De Carvalho, A.P.; De Lima, M.D.C.P.. "A common mechanism for influenza virus fusion activity and inactivation". Biochemistry 32 11 (1993): 2771-2779. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027417786&partnerID=MN8TOARS.
  159. SARMENTO, A.B.; DE LIMA, M.C.P.; OLIVEJRA, C.R.. "Partition of Dopamine Antagonists into Synthetic Lipid Bilayers: the Effect of Membrane Structure and Composition". Journal of Pharmacy and Pharmacology 45 7 (1993): 601-605. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027313440&partnerID=MN8TOARS.
    10.1111/j.2042-7158.1993.tb05660.x
  160. PEDROSO DE LIMA, M.d.C.; RAMALHO-SANTOS, J.; MARTINS, M.d.F.; PATO DE CARVALHO, A.; BAIROS, V.; NIR, S.. "Kinetic modeling of Sendai virus fusion with PC-12 cells: Effect of pH and temperature on fusion and viral inactivation". European Journal of Biochemistry 205 1 (1992): 181-186. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026611884&partnerID=MN8TOARS.
    10.1111/j.1432-1033.1992.tb16766.x
  161. Brandao, F.O.; Silva, C.P.; De Lima, M.C.P.; Oliveira, C.R.. "Prediction of the cytotoxic effects of methotrexate on human T-lymphoblastic leukemia cells". Journal of Experimental and Clinical Cancer Research 11 1 (1992): 51-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026778561&partnerID=MN8TOARS.
  162. Pereira da Silva, C.M.; Pedroso de Lima, M.C.. "Application of flow microcalorimetry to the study of dehydrofolate reductase activities in crude tissue homogenates". Journal of Thermal Analysis 38 4 (1992): 821-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249838370&partnerID=MN8TOARS.
    10.1007/BF01979414
  163. Duzgunes, N.; Pedroso de Lima, M.C.; Stamatatos, L.; Flasher, D.; Alford, D.; Friend, D.S.; Nir, S.. "Fusion activity and inactivation of influenza virus: Kinetics of low pH-induced fusion with cultured cells". Journal of General Virology 73 1 (1992): 27-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026504652&partnerID=MN8TOARS.
  164. Seppen, J.; Ramalho-Santos, J.; de Carvalho, A.P.; ter Beest, M.; Kok, J.W.; Pedroso de Lima, M.C.; Hoekstra, D.. "Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration". BBA - Biomembranes 1106 1 (1992): 209-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026587918&partnerID=MN8TOARS.
    10.1016/0005-2736(92)90240-M
  165. Pedroso de Lima, M.C.; Nir, S.; Flasher, D.; Klappe, K.; Hoekstra, D.; Düzgünes, N.. "Fusion of Sendai virus with human HL-60 and CEM cells: different kinetics of fusion for two isolates". BBA - Biomembranes 1070 2 (1991): 446-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025933996&partnerID=MN8TOARS.
    10.1016/0005-2736(91)90085-M
  166. Silva, C.M.P.; De Lima, M.C.P.; Oliveira, C.R.; Carvlho, A.P.. "A flow microcalorimetric study of the inhibition of acetylcholinesterase by catecholamine derivatives". Thermochimica Acta 179 C (1991): 221-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347785235&partnerID=MN8TOARS.
    10.1016/0040-6031(91)80351-I
  167. Shlomo Nir; Nejat Düzgünes; Maria C. Pedroso De Lima; Dick Hoekstra. "Fusion of enveloped viruses with cells and liposomes". Cell Biophysics 17 2 (1990): 181-201. https://doi.org/10.1007%2Fbf02990496.
    10.1007/bf02990496
  168. Nir, S.; Düzgünes, N.; Pedroso De Lima, M.C.; Hoekstra, D.. "Fusion of enveloped viruses with cells and liposomes - Activity and inactivation". Cell Biophysics 17 2 (1990): 181-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025641298&partnerID=MN8TOARS.
    10.1007/BF02990496
  169. Pedroso de Lima, M.C.; Chiche, B.H.; Debs, R.J.; Düzgünes, N.. "Interaction of antimycobacterial and anti-pneumocystis drugs with phospholipid membranes". Chemistry and Physics of Lipids 53 4 (1990): 361-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025266029&partnerID=MN8TOARS.
    10.1016/0009-3084(90)90034-O
  170. Oliveira, C.R.; Lima, M.C.P.; Carvalho, C.A.M.; Leysen, J.E.; Carvalho, A.P.. "Partition coefficients of dopamine antagonists in brain membranes and liposomes". Biochemical Pharmacology 38 13 (1989): 2113-2120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024340655&partnerID=MN8TOARS.
    10.1016/0006-2952(89)90065-8
  171. Carvalho, C.M.; Oliveira, C.R.; Lima, M.P.; Leysen, J.E.; Carvalho, A.P.. "Partition of ca2+ antagonists in brain plasma membranes". Biochemical Pharmacology 38 13 (1989): 2121-2127. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024475173&partnerID=MN8TOARS.
    10.1016/0006-2952(89)90066-X
  172. Shavnin, S.A.; Pedroso de Lima, M.C.; Fedor, J.; Wood, P.; Bentz, J.; Düzgünes, N.. "Cholesterol affects divalent cation-induced fusion and isothermal phase transitions of phospholipid membranes". BBA - Biomembranes 946 2 (1988): 405-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024262811&partnerID=MN8TOARS.
    10.1016/0005-2736(88)90416-6
  173. Beezer, A.E.; Gooch, C.A.; Hunter, W.H.; Lima, M.C.P.; Smith, B.V.. "Quantitative structure-activity relationships: a group additivity scheme for biological response of E. coli to the action of o-, m- and p-alkoxyphenol". International Journal of Pharmaceutics 38 1-3 (1987): 251-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023628827&partnerID=MN8TOARS.
    10.1016/0378-5173(87)90122-0
  174. Beezer, A.E.; Lima, M.C.P.; Fox, G.G.; Hunter, W.H.; Smith, B.V.. "Solution thermodynamics for o-alkoxyphenols in water and in water-alcohol systems". Thermochimica Acta 116 C (1987): 329-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-39349096788&partnerID=MN8TOARS.
    10.1016/0040-6031(87)88193-5
  175. Beezer, A.E.; Lima, M.C.P.; Fox, G.G.; Arriaga, P.; Hunter, W.H.; Smith, B.V.. "Microcalorimetric measurement of the enthalpies of transfer of a series of ortho- and para-alkoxyphenols from water to octan-1-ol and from isotonic solution to Escherichia coli cells". Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases 83 9 (1987): 2705-2707. http://www.scopus.com/inward/record.url?eid=2-s2.0-0040404893&partnerID=MN8TOARS.
    10.1039/F19878302705
  176. Schreiber, D.R.; De Lima, M.C.P.; Pitzer, K.S.. "Electrical conductivity, viscosity, and density of a two-component ionic system at its critical point". Journal of Physical Chemistry 91 15 (1987): 4087-4091. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001151523&partnerID=MN8TOARS.
  177. Beezer, A.E.; Volpe, P.L.O.; Lima, M.C.P.; Hunter, W.H.. "Solution thermodynamics for alkoxy phenols in alcohol and in water-alcohol systems". Journal of Solution Chemistry 15 4 (1986): 341-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250123191&partnerID=MN8TOARS.
    10.1007/BF00648888
  178. Pitzer, K.S.; De Lima, M.C.P.; Schreiber, D.R.. "Critical point and phase separation for an ionic system". Journal of Physical Chemistry 89 10 (1985): 1854-1855. http://www.scopus.com/inward/record.url?eid=2-s2.0-0039672088&partnerID=MN8TOARS.
  179. de Lima, M.C.P.; Pitzer, K.S.. "Thermodynamics of saturated electrolyte mixtures of NaCl with Na2SO4 and with MgCl2". Journal of Solution Chemistry 12 3 (1983): 187-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847144669&partnerID=MN8TOARS.
    10.1007/BF00648056
  180. de Lima, M.C.P.; Pitzer, K.S.. "Thermodynamics of saturated aqueous solutions including mixtures of NaCl, KCl, and CsCl". Journal of Solution Chemistry 12 3 (1983): 171-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001071681&partnerID=MN8TOARS.
    10.1007/BF00648055
  181. Freund, P.L.; Conceiçâo, M.; Lima, P.; Spiro, M.. "An investigation of non-faradaic electrocatalysis". Journal of Electroanalytical Chemistry 133 2 (1982): 241-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-49049131731&partnerID=MN8TOARS.
    10.1016/0368-1874(82)85141-1
  182. Traca, A.; Lima, M.C.P.. "A high-voltage constant-current generator". Journal of Physics E: Scientific Instruments 13 4 (1980): 387-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019008887&partnerID=MN8TOARS.
    10.1088/0022-3735/13/4/006
  183. Lima, M.C.P.; Kumarasinghe, S.; Spiro, M.. "Transference numbers of a 2:2 electrolyte: Magnesium sulphate in water at 25°C". Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases 74 (1978): 1036-1044. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049106705&partnerID=MN8TOARS.
    10.1039/F19787401036
  184. Conceição, M.; Lima, P.; Spiro, M.. "Analysis of organic amines and acids for water". Analytica Chimica Acta 81 2 (1976): 429-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-49549135217&partnerID=MN8TOARS.
    10.1016/S0003-2670(01)82042-0
Capítulo de livro
  1. Faneca, H.; Düzgünes, N.; Pedroso de Lima, M.C.. "Suicide gene therapy for oral squamous cell carcinoma". In Methods in Molecular Biology: Suicide Gene Therapy, 43-55. Albânia: Springer, 2019.
    10.1007/978-1-4939-8922-5_4
  2. Cardoso, Ana M.; Cardoso, Ana L; Pedroso de Lima, Maria C; Jurado, Amália S. "Non-viral therapeutic approaches for modul. "Non-viral therapeutic approaches for modulation of gene expression: nanotechnological strategies to overcome biological challenges". In Nanoparticles in the Life Sciences and Biomedicine, 409-432. Pan Stanford Publishing, 2018.
    Publicado
  3. De Lima, M.C.P.; Hoekstra, D.. "Liposomes, viruses, and membrane fusion". 2017.
  4. Cardoso, A.M.S.; Silva, S.G.; Luísa Do Vale, M.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Gene Delivery Mediated by Gemini Surfactants: Structure-Activity Relationships". In International Review of Neurobiology. 2016.
    10.1016/B978-0-323-41532-3.00007-5
  5. Cardoso, A.M.; Guedes, J.R.; Cardoso, A.L.; Morais, C.; Cunha, P.; Viegas, A.T.; Costa, R.; Jurado, A.; Pedroso de Lima, M.C.. "Recent Trends in Nanotechnology Toward CNS Diseases". In International Review of Neurobiology, 1-40. Elsevier, 2016.
    10.1016/bs.irn.2016.05.002
  6. Gliedes, J.; Viegas, A.T.; Pedroso de Lima, M.C.; Cardoso, A.L.. "Microglia: A double-edged sword for Alzheimer's disease". In International Review of Neurobiology. 2015.
  7. Cardoso, A.L.; Trabulo, S.M.; Duarte, S.P.; Costa, P.M.; Almeida, L.P.; de Lima, M.C.P.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In International Review of Neurobiology. 2013.
  8. Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Düzgünes, N.; Jurado, A.S.; De Lima, M.C.P.. "Cell-penetrating peptide-based systems for nucleic acid delivery: A biological and biophysical approach". In International Review of Neurobiology. 2012.
    10.1016/B978-0-12-391858-1.00014-9
  9. Maria C. Pedroso de Lima. "Interaction of nucleic acids with biological membranes: activation of inflammatory mechanisms". In A Toxicological/Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level, 203-227. Kerala, Índia: Research Signpost, 2012.
    Publicado
  10. Maria C. Pedroso de Lima. "The role of membrane lipids in a toxicological context: Lessons from microorganism adaptive responses". In A Toxicological/Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level, editado por Jurado, A.S., Maria C.Pedroso de Lima and Leonor Almeida, 1-26. Kerala, Índia: Research Signpost, 2012.
    Publicado
  11. Maria C. Pedroso de Lima. "Cationic liposome-based systems for nucleic acid delivery: from the formulation development to therapeutic applications". In Drug delivery systems: Advanced technologies potentially applicable in personalized treatments, editado por J. Coelho, 153. Springer, 2012.
    Publicado
  12. Moura, V.; da Silva, L.C.G.; Fonseca, N.A.; de Lima, M.C.P.; Simões, S.; Moreira, J.N.. "Emerging targets and novel nanotechnology-based strategies: Changing the treatment paradigm in oncology". In International Review of Neurobiology. 2011.
  13. Faneca, Henrique; Düzgünes, Nejat; Lima, Maria C. Pedroso. "Fluorescence Methods for Evaluating Lipoplex-Mediated Gene Delivery". In Methods in Molecular Biology, 425-437. Humana Press, 2010.
    Publicado • 10.1007/978-1-60761-447-0_29
  14. Cardoso, Ana; Trabulo, Sara; Moreira, João Nuno; Düzgünes, Nejat; de Lima, Maria C. Pedroso. "Targeted Lipoplexes for siRNA Delivery". In Methods in Enzymology, 267-287. Elsevier, 2009.
    10.1016/s0076-6879(09)65014-x
  15. Besse, Benjamin; Soria, Jean-Charles. "Gene silencing therapy in small cell lung cancer – which agents, targets and delivery systems?". In Small-Cell Carcinomas: Causes, Diagnosis, and Treatment, editado por Jonathon G. Maldonado and Mikayla K. Cervantes onathon, 1-51. Nova Science Publishers, 2009.
    10.1007/978-1-60761-524-8_12
  16. Düzgünes, N.; Simões, S.; Lopez-Mesas, M.; de Lima, M.C.P.. "Intracellular delivery of therapeutic oligonucleotides in pH-sensitive and cationic liposomes". In Methods in Molecular Biology, 253-275. New York, Estados Unidos: Marcel Dekker, Inc., 2006.
    Publicado
  17. Maria C. Pedroso de Lima. "pH responsive liposomes: State of the art from biophysics to therapy". In MML series, editado por R. Arshady and K. Kono, 217-250. London, Reino Unido: Kentus Books, 2006.
    Publicado
  18. Düzgünes, N.; Simões, S.; Slepushkin, V.; Pretzer, E.; Flasher, D.; Salem, I.I.; Steffan, G.; Konopka, K.; Pedroso De Lima, M.C.. "Delivery of antiviral agents in liposomes". In Methods in Molecular Biology. 2005.
    10.1016/S0076-6879(05)91020-3
  19. Maria C. Pedroso de Lima. "Sterically stabilized pH-sensitive liposomes". In Methods in Enzymology, editado por J.N. Abelsun and M. I. Simon, 134-147. New York, Estados Unidos: Academic press, 2004.
    Publicado
  20. Simões, S.; Pires, P.; Da Cruz, M.T.G.; Düzgünes, N.; De Lima, M.C.P.. "Gene delivery by cationic liposome-DNA complexes containing transferrin or serum albumin". In Methods in Molecular Biology. 2003.
    10.1016/S0076-6879(03)73024-9
  21. Nejat Düzgünes¸; Sérgio Simöes; Pedro Pires; Maria Pedroso de Lima. "Biophysical characterization of cationic liposome-DNA complexes and their interaction with cells". In Methods in Molecular Biology, 369-383. New York, Estados Unidos: Academic Press, 2003.
    Publicado • 10.1201/9780203904671.ch35
  22. Maria C. Pedroso de Lima. "7Li NMR study of lithium ion transport in perfused human neuroblastoma cells.". In Lithium: Biochemical and Clinical Advances, 211-230. 1996.
    Publicado
  23. Maria C. Pedroso de Lima; João Ramalho-Santos; Nejat Düzgünes; Diana Flasher; Shlomo Nir. "Entry of Enveloped Viruses Into Host Cells: Fusion Activity of the Influenza Virus Hemagglutinin". 1995.
    10.1007/978-3-642-79547-3_8
  24. Catarina R. Oliveira; M. Teresa Almeida; Maria C. Pedroso de Lima. "Membrane Fusion in the Exocytotic Release of Neurotransmitters". 1995.
    10.1007/978-3-642-79547-3_20
  25. Shlomo Nir; Nejat Düzgünes; Dick Hoekstra; João Ramalho-Santos; Maria C. Pedroso de Lima. "Mass action model of virus fusion". 1995.
    10.1007/978-3-642-79547-3_9
  26. Maria C. Pedroso de Lima. "Liposomes, viruses and membrane fusion". In Liposomes as Tools in Basic Research and Industry. New York, Estados Unidos: CRC Press, 1995.
    Publicado
  27. João Ramalho-Santos; Maria da Conceição Pedroso de Lima. "Fusion activity of influenza virus towards target membranes. pH requirements and effect of dehydrating agents". In Biological Membranes: Structure, Biogenesis and Dynamics of Biological Membranes, 313-320. Springer-Verlag, 1994.
    Publicado • 10.1007/978-3-642-78846-8_31
  28. Maria C. Pedroso de Lima. "Kinetics and extent of virus-cell aggregation and fusion". In Viral Fusion Mechanisms, editado por J. Bentz, 437--452. Boca Raton, Estados Unidos: CRC Press, 1993.
    Publicado
  29. Düzgünes, Nejat; Pedroso de Lima, Maria C.; Larsen, Charles E.; Stamatatos, Leonidas; Flasher, Diana; Alford, Dennis R.; Friend, Daniel S.; Nir, Shlomo. "Fusion of Influenza, Sendai and Simian Immunodeficiency Viruses with Cell Membranes and Liposomes". In Cell and Model Membrane Interactions, 179-197. New York, Estados Unidos: Plenum Press, 1991.
    Publicado • 10.1007/978-1-4615-3854-7_11
  30. Maria C. Pedroso de Lima. "Molecular mechanisms of enveloped viruses entry into host cells. Protein dynamics and membrane fusion". In Advances in Membrane Fluidity, 71-97. New York, Estados Unidos: Academic Press, 1991.
    Publicado
  31. Maria C. Pedroso de Lima. "Low temperature thermal energy storage using solid-state phase change materials". In Energy Economics and Management in Industry, 151-155. Oxford, Reino Unido: Pergamon Press, 1984.
    Publicado
Livro
  1. Maria C. Pedroso de Lima. A Toxicological/Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level. Índia: Research Signpost. 2012.
    Publicado
  2. Maria C. Pedroso De Lima; Nejat Düzgünes; Dick Hoekstra. Trafficking of intracellular membranes: From Molecular Sorting to Membrane Fusion. Springer-Verlag. 1995.
    Publicado • 10.1007/978-3-642-79547-3

Propriedade Intelectual

Patente
  1. J.N. Moreira, V. Moura, M.C. Pedroso de Lima and S. Simões. 2018. "pH-sensitive liposome binding to nucleolin". Portugal.
    Concedida/Emitida
  2. J.N. Moreira, V. Moura, M.C. Pedroso de Lima and S. Simões. 2014. "Targeted drug delivery to human diseases and disorders". Estados Unidos.
    Concedida/Emitida
  3. J.N. Moreira, V. Moura, M.C. Pedroso de Lima and S. Simões. 2013. "Targeted delivery to human diseases and disorders". Estados Unidos.
    Concedida/Emitida
  4. J.N. Moreira, V. Moura, M.C. Pedroso de Lima and S. Simões. 2012. "Targeted drug delivery to human diseases and disorders". Estados Unidos.
    Concedida/Emitida
  5. N. Düzgünes, S. Simões, V. Slepushkin and M.C. Pedroso de Lima. 2001. "Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles". Estados Unidos.
    Concedida/Emitida
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2012 - Atual Membrane Lipid Composition and Structure Remodeling by Cell Penetrating Peptide-based Drug Carriers. A Membrane Lipid Therapeutic Strategy for Cancer Diseases
Coorientador de Catarina Mendes Morais
Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2017 Development of chitosan-based nanoparticles for nasal immunization against hepatitis B
Coorientador de Filipa Lebre
Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Non-viral silencing of Machado-Joseph disease through the systemic route
Coorientador de Mariana Oliveira Conceição
Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2015 Inflammation in Alzheimer's disease: Deregulation and modulation of miRNA expression in the mononuclear phagocytic system
Coorientador de Joana Ribeiro Guedes
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2009/04 - 2014/12 MicroRNA modulation in combination with chemotherapeutic drugs as a novel therapeutic strategy for pancreatic cancer
Coorientador de Marta Daniela Passadouro Caetano
Biociências-especialização em Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2014 Nucleic acid delivery systems: from biophysics to biological activity
Coorientador de Ana Maria Sequeira Cardoso
Biociências-especialização em Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2013 MicroRNAs as molecular targets for non-viral gene therapy of glioblastoma: development of a lipid-based nanosystem for nucleic acid delivery to brain tumor cells
Orientador de Pedro Miguel Coutinho da Costa
Bioquímica-Tecnologia Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2012 On the development of antitumoural therapeutic strategies: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination
Orientador de Sónia Patrícia Duarte
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2011 Development of a Novel Approach for Anti-Tumor Therapy Based on the S413-PV Cell Penetrating Peptide to Improve the Intracellular Delivery of Therapeutic Proteins and Nucleic Acids
Orientador de Sara Maria Trabulo
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2010 Targeting of therapeutic genes by new liposome formulations: Evaluation of their efficacy in tumor models
Coorientador de Liliana Simões Mendonça
Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2004 - 2010 Suicide gene therapy for cancer: Anti-tumoral activity mediated by lipoplexes and cellular and molecular mechanisms
Orientador de Sílvia Sousa Neves
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2010 Development of new cationic liposome-based systems to promote gene delivery: Physicochemical characterization and evaluation of biological activity
Orientador de Nuno Miguel Penacho Pereira
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005 - 2008 Gene silencing as a promising strategy for neuroprotection: On the development of a lipid-based system for the delivery of siRNAs to the central nervous system
Orientador de Ana Luísa Colaço Cardoso
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2008 Gene Therapy for Vascular Diseases: Development of Vectors Intracelular Administration of Genes for Angiogenic Factors
Coorientador de Ana Filipe
Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2003 - 2007 Interaction of Lipid-Enveloped Viruses with Cultured Cells: From Early Phases to Nuclear Translocation
Orientador de Isabel Nunes Correia
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003 - 2006 Development of New Liposomal Formulations to Mediate Delivery of Antisense Oligonucleotides for Treatment of Human Leukemia
Coorientador de Cristina Isabel Fonseca
Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2002 - 2006 Cell penetrating Peptides as Promising Systems for Nucleic Acid Delivery and Biological Activity of the S4(13)PV Peptide
Orientador de Miguel Luís Mano
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2006 Nucleo-Cytoplasmic Transport of Structural proteins of African swine Fever Virus: Mechanisms and Virologic Relevance of the Protein p37
Orientador de Ana Sofia Bregieiro Eulálio
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2001 - 2005 New Lipid-Based Systems for Aplication in Antitumor Gene Therapy
Orientador de Henrique Manuel dos Santos faneca
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2001 - 2005 Optimization of Cationic Liposome /DNA Complexes for Transfection of Neuronal Cells
Orientador de Maria Teresa Girão da Cruz
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2000 - 2004 Cationic Liposome/DNA Complexes for Application in Gene Therapy: Mechanisms of Internalization Intracellular Delivery of Genetic Material
Orientador de Pedro de Pina Catarino Pires
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1995 - 1999 The Use of Fusogenic Liposomes in Gene Therapy
Coorientador de Sérgio Paulo de Magalhães Simões
Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
1994 - 1997 Fusion Activity of Lipid-Enveloped Viruses: Membrane Fusion promoted by Influenza and Sendai Viruses
Orientador de João Ramalho de Sousa Santos
Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1993 - 1997 In vitro Studies of Infection and Fusion Mechanisms of African Swine Fever Virus
Coorientador de Catarina Bernardes
Ciências Farmacêuticas (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992 - 1995 Biochemical Effects of Anticancer Drugs in Human Leukemia Cells: Study in Limphoblastic Cultured Cells
Orientador de Cristina Isabel Pereira da Silva
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2021/02 - Atual Evaluator of research grant proposals - National Science Centre, Poland
Avaliador
Narodowe Centrum Nauki , Polónia
2016 - Atual Evaluator of research grant proposals - The Teresa Rosenbaum Golden Charitable Trust
Avaliador
Rosetrees Trust, Reino Unido
2016 - Atual Evaluator of research grant proposals - China Israel Cooperative Scientific Research on Brain Sciences
Avaliador
Ministry of Science Technology and Space, Israel
2012 - Atual Evaluator of research proposals - Acordos Bilaterais
Avaliador
Fundação para a Ciência e a Tecnologia, Portugal

Membro de associação

Nome da associação Tipo de participação
2020 - Atual European Peptide Society Portuguese Network of EVs (Portuguese Network for Studies of Extracellular Vesicles (EVs).
Distinções

Prémio

2013 2013 | International Exiqon award
Exiqon - Grant Programme: Copenhagen, DK 2013 , Dinamarca