Paula Isabel da Silva Moreira (9C16-2F47-6D91)

Curriculum Vitae

Paula Isabel da Silva Moreira

Paula I. Moreira received her PhD in Biomedical Sciences from University of Coimbra, Portugal, in 2007. Currently, she is Assistant Professor at the Faculty of Medicine and Principal Investigator at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. Moreira's group is interested in elucidating the role of energy metabolism, with an emphasis on mitochondria (energy, homeostasis and signals) and metabolic hormones-mediated signaling pathways in brain changes occurring in metabolic disorders (e.g. diabetes and obesity) and neurodegenerative diseases, particularly Alzheimer disease. We are also interested in clarifying the role of hypoxia and sex/gender in the neurodegenerative events that characterize these pathologies. Additionally, we are exploring the therapeutic potential of anti-diabetic drugs, metabolic hormones and mitochondrial modulators. To achieve our goals we use several experimental models such as isolated mitochondria, in vitro and in vivo models of disease and human samples. Moreira has published more than 200 scientific peer-reviewed articles. She is deputy editor of Journal of Alzheimer's Disease, associate editor of Journal of Alzheimer's Disease Reports and Frontiers of Aging Neuroscience, section editor of BBA-Molecular Basis of Disease and belongs to the editorial board of Antioxidants and Redox Signaling and Aging Brain. Paula Moreira won the Stimulus to Research prize, in 2003, supported by the Calouste Gulbenkian Foundation and, in 2008, the L¿Oréal for Women in Science Award supported by L'Oreal Portugal/UNESCO/ FCT.

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Identificação

Identificação pessoal

Nome completo: Paula Isabel da Silva Moreira

Nomes de citação

Moreira, Paula
Paula I. Moreira
Moreira, PI
Moreira, Paula Isabel

Identificadores de autor

Ciência ID: 9C16-2F47-6D91
ORCID iD: 0000-0001-5177-6747
AuthenticusID: R-000-E6F
Google Scholar ID: https://scholar.google.pt/citations?user=5JO6pzkAAAAJ&hl=pt-PT
Researcher Id: B-3608-2009
Scopus Author Id: 56038291200

Endereços de correio eletrónico

pismoreira@gmail.com (Profissional)
pimoreira@fmed.uc.pt (Profissional)
venta@ci.uc.pt (Profissional)

Moradas

Pólo III, Pólo das Ciências da Saúde, 3000-548, Azinhaga de Santa Comba, Celas, Coimbra, Portugal (Profissional)
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

https://www.cnc.uc.pt/pt/people/p-moreira (Profissional)
https://www.researchgate.net/profile/Paula_Moreira3 (Profissional)
https://publons.com/researcher/999744/paula-i-moreira/ (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)

Formação

	Grau	Classificação
2007/07/16 Concluído	Ciências Biomédicas (Doutoramento) Especialização em Neurociências Universidade de Coimbra - Faculdade de Medicina, Portugal "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties" (TESE/DISSERTAÇÃO)	Aprovado com Distinção e Louvor, por unanimidade
2002/05/23 Concluído	Biologia Celular (Mestrado) Especialização em Não Aplicável Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Effect of Aß25-35 in the mitochondrial permeability transition pore: a comparative study " (TESE/DISSERTAÇÃO)
1998/07/09 Concluído	Biologia (Licenciatura) Especialização em Ramo Científico Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2007 - Atual	Investigador (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2016 - Atual	Professor Auxiliar (Docente Universitário)	Universidade de Coimbra - Faculdade de Medicina, Portugal
	Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015	Professor Auxiliar Convidado (Docente Universitário)	University of Texas at San Antonio, Estados Unidos
	University of Texas at San Antonio College of Sciences, Estados Unidos
2011 - 2015	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Coimbra - Faculdade de Medicina, Portugal
	Universidade de Coimbra - Faculdade de Medicina, Portugal
2005 - 2011	Assistente (Docente Universitário)	Universidade de Coimbra - Faculdade de Medicina, Portugal
	Universidade de Coimbra - Faculdade de Medicina, Portugal

Projetos

Bolsa

	Designação	Financiadores
2022 - Atual	Zfra 1-31: an early intervention in T2D-associated neurodegeneration EXPL/MED-FSL/0033/2021 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Em curso
2020/02 - Atual	Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism SFRH/BD/148801/2019 Orientador Universidade de Coimbra - Faculdade de Medicina, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Em curso
2019/04/01 - Atual	Rational Drug Design of novel potent multifunctional agents for Alzheimer’s Disease treatment SFRH/BD/138460/2018 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Em curso
2023 - 2024	Exploring the therapeutic potential of mitochondrial uncouplers in the context of Alzheimer's disease ERG2023 Orientador Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	European Society for Clinical Investigation Em curso
2022 - 2023	An exploratory study of the gender-specific response to hypoxia in Alzheimer's disease ERG2022 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Society for Clinical Investigation Em curso
2022 - 2023	MitoBOOST v2.0 - Prova de Conceito para o Uso de Polifenóis Dirigidos à Mitocôndria para Tratar a Doença do Fígado Gordo Não-Alcoólico MitoBOOST v2.0 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Em curso
2021 - 2022	Zfra 1-31 peptide as a new candidate to fight type 2 diabetes-associated brain damage: a pilot study ERG 2021 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Society for Clinical Investigation Em curso
2016/03/01 - 2019/03/31	Exploring the crosstalk of neuronal WWOX and mitochondria in type 2 diabetes-associated neurodegeneration SFRH/BPD/107741/2015 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2016/07/01 - 2019/01/31	Unveiling the potential of HIF-1a as a biomarker and therapeutic target in Alzheimer’s disease SFRH/BPD/109822/2015 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2017 - 2019	Unravelling the neuroprotective role of peripheral co-administration of liraglutide and ghrelin on brain and cognitive function in Huntington disease SFRH/BPD/84473/2012 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2015 - 2018	Does habitual physical activity mitigates chemotherapy-induced cardiac and brain dysfunction in a mouse model of prostate cancer? Role of mitochondrial-mediated mechanisms SFRH/BPD/108322/2015 Orientador Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal	Concluído
2015 - 2018	HDAC3 neurophysiology and drug targeting in neurodegeneration SFRH/BPD/102259/2014 Orientador Universidade do Porto Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2014/05/01 - 2017	Mild mitochondrial uncoupling: exploring its protective effects against brain damage associated to insulin-induced hypoglycemic events in type 1 diabetes SFRH/BPD/95770/2013 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Fundação para a Ciência e a Tecnologia, I.P. Concluído
2013/03/01 - 2016/06/30	Mitochondrial trafficking in Alzheimer’s disease and hypoxic preconditioning: unveiling the role of the hypoxia up-regulated mitochondrial movement regulator SFRH/BPD/84163/2012 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2013 - 2016	IMPACT OF PERIPHERAL EXENDIN-4 THERAPY ON THE MOLECULAR MECHANISMS UNDERLYING DIFFERENTIAL GENDER-RELATED BRAIN FUNCTION IN LONG-TERM TYPE 2 DIABETES SFRH/BPD/84473/2012 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2009/03 - 2013/02	Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria SFRH/BD/43965/2008 Orientador Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2009/01/01 - 2012/12/31	DECIPHERING THE ROLE OF MITOCHONDRIA AND UNCOUPLING PROTEINS IN HYPOGLYCEMIA- AND/OR HYPERGLYCEMIA-INDUCED BRAIN INJURY SFRH/BD/43968/2008 Orientador Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2008/03/01 - 2012/02/29	ROLE OF MITOCHONDRIA IN THE REGULATION OF THE TRANSCRIPTION FACTOR HYPOXIA-INDUCIBLE FACTOR-1 IN BRAIN ENDOTHELIUM: POTENTIAL PROTECTION AGAINST DIABETIC COMPLICATIONS SFRH/BD/40702/2007 Orientador Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2007 - 2010	Impact of aging and gender in diabetic brain metabolism, oxidative stress and inflammation: Is there a (protective) role for insulin therapy? SFRH/BPD/26872/2006 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2002 - 2006	Mitocôndria e sua relação com o envelhecimento, a doença de Alzheimer e a diabetes: papel da proteína b-amilóide SFRH/BD/5320/2001 Bolseiro de Doutoramento Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2000 - 2002	Efeito do peptídeo beta-amilóide no poro de permeabilidade transitória da mitocôndria PRAXIS XXI/BM/20952/1999 Bolseiro de Mestrado Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído

Projeto

	Designação	Financiadores
2020/01/01 - 2026/12/31	Multidisciplinary Institute of Ageing (MIA) - Portugal info:eu-repo/grantAgreement/EC/H2020/857524/EU Investigador	European Commission Em curso
2019/07 - 2021/07	A Saúde no Saber 45-2019/478 Investigador Ciência Viva, Portugal	Em curso
2018 - 2021	The ups and downs of cellular stress: the MAMs hypothesis for Bipolar disorder pathophysiology CENTRO-01-0145-FEDER-028214 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Em curso
2017/01 - 2020	HealthyAging2020 HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323 Investigador	Comissão de Coordenação e Desenvolvimento Regional do Centro
2016/04/01 - 2019/12/31	Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos SII&DT 3269 Drugs2CAD Investigador Universidade de Coimbra, Portugal	Agência Nacional de Inovação, S.A. Concluído
2018 - 2019	Brain protection by Evolocumab in individuals at high risk for cardiovascular disease: from bench to bedside PEPITA2018 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade de Coimbra - Faculdade de Medicina Concluído
2016 - 2018	Targeting huntingtin proteostasis and mitochondria to prevent neuronal dysfunction in Huntington's disease PTDC/NEU-NMC/0412/2014 Investigador	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2018	The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression? Prémio Mantero Belard 2015 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2014/03 - 2015/02	Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing Provided by PTCRIS: 135805 135805 Investigador	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2014 - 2015	Selenate and Reduction of Neurofibrillary Tangle Formation: Role of Selenoproteins U54MD008149 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	National Institute on Minority Health and Health Disparities Concluído
2013 - 2015	Mitochondrial Trafficking In Alzheimer Disease: Revealing the Role of HUMMR NIRG-13-282387 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Alzheimer's Association
2013 - 2015	New Strategies to Manage Brain Diseases CENTRO-07-ST24-FEDER-002002 Investigador	Programa Operacional Regional do Centro - Projecto Mais Centro Concluído
2013 - 2014	Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role? MOREIRA06JAN13 Investigador responsável	Faculty of Medicine, University of Coimbra
2010/04 - 2013/09	Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem. 108326 Provided by PTCRIS: 108326 Investigador	Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2013/08	Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease 110990 Provided by PTCRIS: 110990 Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P.
2010/04 - 2013/03	The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins 103325 Provided by PTCRIS: 103325 Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P.
2008/11 - 2012/03	A new route for endothelial dysfunction on diabetes: From phenotypes to molecules 67498 Provided by PTCRIS: 67498 Investigador	Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2012	Influence of gender on the molecular mechanisms underlying aging-related changes in diabetic brain: the impact of insulin therapy PMADSC Investigador responsável	Faculty of Medicine, University of Coimbra
2008 - 2010	Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs III-45 Investigador responsável Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Institute for Interdisciplinary Research, University of Coimbra Concluído
2008 - 2009	Da diabetes à demência: Explorando as vias de sinalização mediadas pela mitocôndria e suas proteínas desacopladoras ---- Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2007 - 2009	Exploring the crosstalk between mitochondrial reactive oxygen species and the transcriptional factor hypoxia factor-1 in brain and retinal endothelium ------ Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Foundation for the Study of Diabetes Concluído

Produções

Publicações

Artigo em revista	Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease". Frontiers in Aging Neuroscience 15 (2023): http://dx.doi.org/10.3389/fnagi.2023.1161847. 10.3389/fnagi.2023.1161847 Cristina Carvalho; Paula I. Moreira. "Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria". Current Opinion in Neurobiology (2023): https://doi.org/10.1016/j.conb.2023.102694. 10.1016/j.conb.2023.102694 Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases". Biology (2023): https://doi.org/10.3390/biology12030414. 10.3390/biology12030414 Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A.. "Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice". Free Radical Biology and Medicine 198 (2023): S5-S6. http://dx.doi.org/10.1016/j.freeradbiomed.2022.12.030. 10.1016/j.freeradbiomed.2022.12.030 Bernardes, Rui; Ghalati, Maryam; Ferreira, Hugo; Martins, João; Guimarães, Pedro; Moreira, Paula; Ambrósio, António; Castelo-Branco, Miguel; Serranho, Pedro. "Longitudinal OCT texture analysis to assess the retinal changes in the triple-transgenic mouse model of Alzheimer's disease". Acta Ophthalmologica 100 S275 (2022): http://dx.doi.org/10.1111/j.1755-3768.2022.0173. 10.1111/j.1755-3768.2022.0173 Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira. "WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04508-7. 10.1007/s00018-022-04508-7 Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Stage-independent biomarkers for Alzheimer’s disease from the living retina: an animal study". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18113-y. 10.1038/s41598-022-18113-y Antónia Diniz; Marco G. Alves; Emanuel Candeias; Ana I. Duarte; Paula I. Moreira; Branca M. Silva; Pedro F. Oliveira; Luís Rato. "Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23168912. 10.3390/ijms23168912 Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.832195. 10.3389/fnagi.2022.832195 Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". Cellular and Molecular Life Sciences 79 4 (2022): http://dx.doi.org/10.1007/s00018-022-04211-7. 10.1007/s00018-022-04211-7 Correia, Sónia C.; Alves, Marco G.; Oliveira, Pedro F.; Casadesus, Gemma; LaManna, Joseph; Perry, George; Moreira, Paula I.. "Hypoxic preconditioning averts sporadic Alzheimer’s disease-like phenotype in rats: a focus on mitochondria". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2019.8007. 10.1089/ars.2019.8007 Susana Cardoso; Paula I. Moreira. "Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222413470. 10.3390/ijms222413470 Sónia C. Correia; Paula I. Moreira. "Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!". Cellular and Molecular Neurobiology (2021): https://doi.org/10.1007/s10571-021-01148-6. 10.1007/s10571-021-01148-6 Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease". Biomedicines 9 8 (2021): 881-881. https://doi.org/10.3390/biomedicines9080881. 10.3390/biomedicines9080881 Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease". Aging (2021): http://dx.doi.org/10.18632/aging.202916. 10.18632/aging.202916 Carvalho, Cristina; Moreira, Paula I.. "WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration". Metabolism 116 (2021): 154616. http://dx.doi.org/10.1016/j.metabol.2020.154616. 10.1016/j.metabol.2020.154616 Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira. "IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis". Biomedicines 9 2 (2021): 158-158. https://doi.org/10.3390/biomedicines9020158. 10.3390/biomedicines9020158 Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira. "Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease". International Journal of Molecular Sciences 22 1 (2021): 461-461. https://doi.org/10.3390/ijms22010461. 10.3390/ijms22010461 Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280. 10.1080/15548627.2020.1797280 Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique. "PINK1/PARKIN signalling in neurodegeneration and neuroinflammation". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-01062-w. Publicado • 10.1186/s40478-020-01062-w Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al. "Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort". International Journal of Environmental Research and Public Health (2020): https://doi.org/10.3390/ijerph17176051. 10.3390/ijerph17176051 Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al. "Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing". Nature Reviews Drug Discovery (2020): http://dx.doi.org/10.1038/s41573-020-0072-x. 10.1038/s41573-020-0072-x Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al. "Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 6 (2020): 165752. http://dx.doi.org/10.1016/j.bbadis.2020.165752. 10.1016/j.bbadis.2020.165752 Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui. "Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer's disease". Health and Technology (2020): 1816-1821. http://dx.doi.org/10.1007/s12553-020-00413-w. 10.1007/s12553-020-00413-w Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535. 10.3390/biom10040535 Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al. "Liraglutide Protects Against Brain Amyloid-ß1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21051746. 10.3390/ijms21051746 Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A.. "The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice". Free Radical Biology and Medicine 146 (2020): 372-382. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021. 10.1016/j.freeradbiomed.2019.11.021 Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR. "An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease". Future Medicinal Chemistry 11 24 (2019): 3179-3194. http://dx.doi.org/10.4155/fmc-2019-0163. 10.4155/fmc-2019-0163 Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa. "Is Alzheimer's disease an inflammasomopathy?". Ageing Research Reviews 56 (2019): 100966. http://dx.doi.org/10.1016/j.arr.2019.100966. 10.1016/j.arr.2019.100966 Bernardes, Rui; Ferreira, Hugo; Martins, João; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro. "Retinal thickness of the triple-transgenic mice model of Alzheimer's disease at the age of one month". Acta Ophthalmologica 97 S263 (2019): http://dx.doi.org/10.1111/j.1755-3768.2019.5467. 10.1111/j.1755-3768.2019.5467 Cabral Pinto, Marina M. S.; Marinho-Reis, Paula; Almeida, Agostinho; Pinto, Edgar; Neves, Orquídia; Inácio, Manuela; Gerardo, Bianca; et al. "Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area". International Journal of Environmental Research and Public Health 16 22 (2019): 4560. http://dx.doi.org/10.3390/ijerph16224560. 10.3390/ijerph16224560 Chiquita, Samuel; Campos, Elisa J.; Castelhano, João; Ribeiro, Mário; Sereno, José; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco. "Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study". Alzheimer's Research & Therapy 11 1 (2019): http://dx.doi.org/10.1186/s13195-019-0542-8. 10.1186/s13195-019-0542-8 Correia, Sónia C.; Carvalho, Cristina; Cardoso, Susana; Moreira, Paula I.. "Post-translational modifications in brain health and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865 8 (2019): 1947-1948. http://dx.doi.org/10.1016/j.bbadis.2019.05.006. 10.1016/j.bbadis.2019.05.006 Pinho, Tiffany S.; Correia, Sónia C.; Perry, George; Ambrósio, António Francisco; Moreira, Paula I.. "Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865 8 (2019): 2048-2059. http://dx.doi.org/10.1016/j.bbadis.2018.10.037. 10.1016/j.bbadis.2018.10.037 Susana Cardoso; Paula I. Moreira. "Diabesity and brain disturbances: A metabolic perspective". Molecular Aspects of Medicine 66 (2019): 71-79. https://doi.org/10.1016/j.mam.2018.10.002. 10.1016/j.mam.2018.10.002 Chiquita, Samuel; Ribeiro, Mário; Castelhano, João; Oliveira, Francisco; Sereno, José; Batista, Marta; Abrunhosa, Antero; et al. "A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss". Human Molecular Genetics 28 13 (2019): 2174-2188. http://dx.doi.org/10.1093/hmg/ddz045. 10.1093/hmg/ddz045 Chiquita, Samuel; Rodrigues-Neves, Ana C.; Baptista, Filipa I.; Carecho, Rafael; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.. "The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel". Molecular Neurobiology 56 8 (2019): 5416-5435. http://dx.doi.org/10.1007/s12035-018-1461-6. 10.1007/s12035-018-1461-6 Moreira, PI. "Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease.". Advances in experimental medicine and biology (2019): https://doi.org/10.1007/978-981-13-3540-2_9. 10.1007/978-981-13-3540-2_9 Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Baptista, Filipa; Moreira, Paula; Ambrósio, António. "Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer's disease?". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00020. 10.3389/conf.fncel.2019.01.00020 Ana I. Duarte; Marie Sjögren; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira; Maria Björkqvist. "Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-27121-w. 10.1038/s41598-018-27121-w Tiffany S. Pinho; Diogo M. Verde; Sónia C. Correia; Susana M. Cardoso; Paula I. Moreira. "O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease". Ageing Research Reviews 46 (2018): 32-41. https://doi.org/10.1016/j.arr.2018.05.003. 10.1016/j.arr.2018.05.003 Cabral Pinto, Marina M. S.; Marinho-Reis, A. Paula; Almeida, Agostinho; Freitas, Sandra; Simões, Mário R.; Diniz, M. Luísa; Pinto, Edgar; et al. "Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing". Exposure and Health 11 3 (2018): 181-194. http://dx.doi.org/10.1007/s12403-018-0274-1. 10.1007/s12403-018-0274-1 Mendes, D.; Oliveira, M.M.; Moreira, P.I.; Coutinho, J.; Nunes, F.M.; Pereira, D.M.; Valentão, P.; Andrade, P.B.; Videira, R.A.. "Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology". Journal of Nutritional Biochemistry 55 (2018): 165-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043298266&partnerID=MN8TOARS. 10.1016/j.jnutbio.2018.02.001 Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease". Neuropharmacology (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044268663&partnerID=MN8TOARS. 10.1016/j.neuropharm.2018.01.044 Marques-Aleixo, I.; Santos-Alves, E.; Oliveira, P.J.; Moreira, P.I.; Magalhães, J.; Ascensão, A.. "The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy". Biochimica et Biophysica Acta - Reviews on Cancer 1869 2 (2018): 189-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041805508&partnerID=MN8TOARS. 10.1016/j.bbcan.2018.01.002 Moreira, P.I.. "Sweet Mitochondria: A Shortcut to Alzheimer's Disease". Journal of Alzheimer's Disease 62 3 (2018): 1391-1401. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044360897&partnerID=MN8TOARS. 10.3233/JAD-170931 Candeias, Emanuel; Sebastião, Inês; Cardoso, Susana; Carvalho, Cristina; Santos, Maria Sancha; Oliveira, Catarina Resende; Moreira, Paula I.; Duarte, Ana I.. "Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats". Molecular Neurobiology (2017): http://dx.doi.org/10.1007/s12035-017-0622-3. 10.1007/s12035-017-0622-3 Ana I. Plácido; Cláudia M. F. Pereira; Sónia C. Correira; Cristina Carvalho; Catarina R. Oliveira; Paula I. Moreira. "Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells". Molecular Neurobiology (2017): http://dx.doi.org/10.1007/s12035-015-9640-1. 10.1007/s12035-015-9640-1 Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R.. "Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid". Critical Reviews in Clinical Laboratory Sciences 54 3 (2017): 185-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS. 10.1080/10408363.2017.1299682 Rueli, R.H.L.H.; Torres, D.J.; Dewing, A.S.T.; Kiyohara, A.C.; Barayuga, S.M.; Bellinger, M.T.; Uyehara-Lock, J.H.; et al. "Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology". Journal of Alzheimer's Disease 55 2 (2017): 749-762. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999116043&partnerID=MN8TOARS. 10.3233/JAD-151208 Cardoso, S.; Seiça, R.M.; Moreira, P.I.. "Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease". Expert Review of Neurotherapeutics 17 1 (2017): 77-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003782022&partnerID=MN8TOARS. 10.1080/14737175.2016.1205488 Cabral Pinto, M.M.S.; Marinho-Reis, A.P.; Almeida, A.; Ordens, C.M.; Silva, M.M.V.G.; Freitas, S.; Simões, M.R.; et al. "Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements". Environmental Geochemistry and Health (2017): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014615707&partnerID=MN8TOARS. 10.1007/s10653-017-9928-3 Cardoso, S.; Seiça, R.M.; Moreira, P.I.. "Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects". Neurotoxicity Research (2017): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028984223&partnerID=MN8TOARS. 10.1007/s12640-017-9805-y Marques-Aleixo, I.; Santos-Alves, E.; Balça, M.M.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling". Mitochondrion 26 (2016): 43-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949871382&partnerID=MN8TOARS. 10.1016/j.mito.2015.12.002 Candeias, E.; Duarte, A.I.; Sebastião, I.; Fernandes, M.A.; Plácido, A.I.; Carvalho, C.; Correia, S.; et al. "Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology". Molecular Neurobiology (2016): 1-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991075553&partnerID=MN8TOARS. 10.1007/s12035-016-0155-1 Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356". Autophagy 12 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84975859238&partnerID=MN8TOARS. 10.1080/15548627.2016.1147886 Correia, S.C.; Perry, G.; Moreira, P.I.. "Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks". Biochimica et Biophysica Acta - Molecular Basis of Disease 1862 10 (2016): 1909-1917. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979699672&partnerID=MN8TOARS. 10.1016/j.bbadis.2016.07.010 Cardoso, S.; Carvalho, C.; Correia, S.C.; Seiça, R.M.; Moreira, P.I.. "Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine". Brain Pathology 26 5 (2016): 632-647. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988642816&partnerID=MN8TOARS. 10.1111/bpa.12402 Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013763791&partnerID=MN8TOARS. 10.1080/15548627.2015.1100356 Carvalho, C.; Correia, S.C.; Perry, G.; Castellani, R.J.; Moreira, P.I.. "Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview". Journal of Neural Transmission (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84922386380&partnerID=MN8TOARS. 10.1007/s00702-015-1367-7 Monteiro-Cardoso, V.F.; Castro, M.; Oliveira, M.M.; Moreira, P.I.; Peixoto, F.; Videira, R.A.. "Age-dependent biochemical dysfunction in skeletal muscle of triple-transgenic mouse model of Alzheimer's disease". Current Alzheimer Research 12 2 (2015): 100-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924862255&partnerID=MN8TOARS. Sena, C.M.; Pereira, A.M.; Carvalho, C.; Fernandes, R.; Seiça, R.M.; Oliveira, C.R.; Moreira, P.I.. "Type 2 diabetes aggravates alzheimer's disease-associated vascular alterations of the aorta in mice". Journal of Alzheimer's Disease 45 1 (2015): 127-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924181831&partnerID=MN8TOARS. 10.3233/JAD-141008 Nunes, A.R.; Alves, M.G.; Tomás, G.D.; Conde, V.R.; Cristóvão, A.C.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats". British Journal of Nutrition 113 5 (2015): 832-842. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926409736&partnerID=MN8TOARS. 10.1017/S0007114514004395 Correia, S.C.; Resende, R.; Moreira, P.I.; Pereira, C.M.. "Alzheimer's disease-related misfolded proteins and dysfunctional organelles on autophagy menu". DNA and Cell Biology 34 4 (2015): 261-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926636149&partnerID=MN8TOARS. 10.1089/dna.2014.2757 Carvalho, C.; Correia, S.C.; Cardoso, S.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I.. "The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases". Expert Review of Neurotherapeutics 15 8 (2015): 867-884. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937838385&partnerID=MN8TOARS. 10.1586/14737175.2015.1058160 González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P.. "Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions". Pharmaceutical Biology (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84945231706&partnerID=MN8TOARS. 10.3109/13880209.2015.1072829 Marques-Aleixo, I.; Santos-Alves, E.; Balça, M.M.; Rizo-Roca, D.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers". Neuroscience 301 (2015): 480-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947795323&partnerID=MN8TOARS. 10.1016/j.neuroscience.2015.06.027 Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 8 (2015): 1665-1675. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929430489&partnerID=MN8TOARS. 10.1016/j.bbadis.2015.05.001 Rato, L.; Alves, M.G.; Duarte, A.I.; Santos, M.S.; Moreira, P.I.; Cavaco, J.E.; Oliveira, P.F.. "Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells". International Journal of Biochemistry and Cell Biology 66 (2015): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936877372&partnerID=MN8TOARS. 10.1016/j.biocel.2015.07.001 Alves, M.G.; Martins, A.D.; Moreira, P.I.; Carvalho, R.A.; Sousa, M.; Barros, A.; Silva, J.; et al. "Metabolic fingerprints in testicular biopsies from type 1 diabetic patients". Cell and Tissue Research (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930607586&partnerID=MN8TOARS. 10.1007/s00441-015-2217-5 Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Oliveira, C.R.; Moreira, P.I.. "Modulation of endoplasmic reticulum stress: An opportunity to prevent neurodegeneration?". CNS and Neurological Disorders - Drug Targets 14 4 (2015): 518-533. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929628537&partnerID=MN8TOARS. Moreira, PI; Moreira, P.I.. "Metformin in the diabetic brain: friend or foe?". Annals of Translational Medicine 2 6 (2014): 54-56. http://dx.doi.org/10.3978/j.issn.2305-5839.2014.06.10. Acesso aberto • Publicado • 10.3978/j.issn.2305-5839.2014.06.10 Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Duarte, A.I.; Santos, M.S.; Moreira, P.I.. "Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 7 (2014): 1154-1166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899789863&partnerID=MN8TOARS. 10.1016/j.bbadis.2014.04.011 Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al. "The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 9 (2014): 1444-1453. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS. 10.1016/j.bbadis.2014.05.003 Cardoso, S.; Carvalho, C.; Marinho, R.; Simões, A.; Sena, C.M.; Matafome, P.; Santos, M.S.; Seiça, R.M.; Moreira, P.I.. "Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status". Journal of Bioenergetics and Biomembranes (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901509164&partnerID=MN8TOARS. 10.1007/s10863-014-9551-2 Rato, L.; Duarte, A.I.; Tomás, G.D.; Santos, M.S.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Alves, M.G.; Oliveira, P.F.. "Pre-diabetes alters testicular PGC1-a/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress". Biochimica et Biophysica Acta - Bioenergetics 1837 3 (2014): 335-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892411578&partnerID=MN8TOARS. 10.1016/j.bbabio.2013.12.008 Alves, M.G.; Martins, A.D.; Vaz, C.V.; Correia, S.; Moreira, P.I.; Oliveira, P.F.; Socorro, S.. "Metformin and male reproduction: Effects on Sertoli cell metabolism". British Journal of Pharmacology 171 4 (2014): 1033-1042. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893042451&partnerID=MN8TOARS. 10.1111/bph.12522 Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F.. "Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells". Molecular Neurobiology (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS. 10.1007/s12035-014-8740-7 Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Seiça, R.; Santos, M.S.; Moreira, P.I.. "Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes". Molecular and Cellular Biochemistry (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901561690&partnerID=MN8TOARS. 10.1007/s11010-014-2076-5 Carvalho, C.; Katz, P.S.; Dutta, S.; Katakam, P.V.G.; Moreira, P.I.; Busija, D.W.. "Increased susceptibility to amyloid-ß toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions". Journal of Alzheimer's Disease 38 1 (2014): 75-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887249119&partnerID=MN8TOARS. 10.3233/JAD-130464 Sebastião, I.; Candeias, E.; Santos, M.S.; de Oliveira, C.R.; Moreira, P.I.; Duarte, A.I.. "Insulin as a bridge between type 2 diabetes and alzheimer disease - how anti-diabetics could be a solution for dementia". Frontiers in Endocrinology 5 JUL (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84905437740&partnerID=MN8TOARS. 10.3389/fendo.2014.00110 Cardoso, S.; Correia, S.; Carvalho, C.; Candeias, E.; Plácido, A.I.; Duarte, A.I.; Seiça, R.M.; Moreira, P.I.. "Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection". Journal of Bioenergetics and Biomembranes 47 1-2 (2014): 119-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922536968&partnerID=MN8TOARS. 10.1007/s10863-014-9580-x Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Can tea consumption be a safe and effective therapy against diabetes mellitus-induced neurodegeneration?". Current Neuropharmacology 12 6 (2014): 475-489. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924963252&partnerID=MN8TOARS. Monteiro-Cardoso, V.F.; Oliveira, M.M.; Melo, T.; Domingues, M.R.M.; Moreira, P.I.; Ferreiro, E.; Peixoto, F.; Videira, R.A.. "Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease". Journal of Alzheimer's Disease 43 4 (2014): 1375-1392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919926803&partnerID=MN8TOARS. 10.3233/JAD-141002 Carvalho, C.; Correia, S.C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I.. "Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes". Current Neurovascular Research 11 4 (2014): 330-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925786114&partnerID=MN8TOARS. Plácido, A.I.; Oliveira, C.R.; Moreira, P.I.; Pereira, C.M.F.. "Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells". Molecular Neurobiology (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84905883677&partnerID=MN8TOARS. 10.1007/s12035-014-8819-1 Martins, A.D.; Alves, M.G.; Simões, V.L.; Dias, T.R.; Rato, L.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Oliveira, P.F.. "Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes". Cell and Tissue Research 354 3 (2013): 861-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890482473&partnerID=MN8TOARS. 10.1007/s00441-013-1722-7 Mondragón-Rodríguez, S.; Perry, G.; Zhu, X.; Moreira, P.I.; Acevedo-Aquino, M.C.; Williams, S.. "Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: Implications for Alzheimer's disease". Oxidative Medicine and Cellular Longevity (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880863640&partnerID=MN8TOARS. 10.1155/2013/940603 Correia, S.C.; Perry, G.; Castellani, R.; Moreira, P.I.. "Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?". Journal of Neurochemistry 127 1 (2013): 4-6. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884846458&partnerID=MN8TOARS. 10.1111/jnc.12406 Moreira, P.I.. "High-sugar diets, type 2 diabetes and Alzheimer's disease". Current Opinion in Clinical Nutrition and Metabolic Care 16 4 (2013): 440-445. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880326722&partnerID=MN8TOARS. 10.1097/MCO.0b013e328361c7d1 Alves, M.G.; Neuhaus-Oliveira, A.; Moreira, P.I.; Socorro, S.; Oliveira, P.F.. "Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells". Reproductive Toxicology 38 (2013): 81-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876339594&partnerID=MN8TOARS. 10.1016/j.reprotox.2013.03.005 Carvalho, C.; Machado, N.; Mota, P.C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies". Journal of Alzheimer's Disease 35 3 (2013): 623-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880196052&partnerID=MN8TOARS. 10.3233/JAD-130005 Cardoso, S.; Santos, M.S.; Moreno, A.; Moreira, P.I.. "UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats". Journal of Bioenergetics and Biomembranes 45 4 (2013): 397-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881311117&partnerID=MN8TOARS. 10.1007/s10863-013-9503-2 Alves, M.G.; Rato, L.; Carvalho, R.A.; Moreira, P.I.; Socorro, S.; Oliveira, P.F.. "Hormonal control of Sertoli cell metabolism regulates spermatogenesis". Cellular and Molecular Life Sciences 70 5 (2013): 777-793. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873719667&partnerID=MN8TOARS. 10.1007/s00018-012-1079-1 Moreno, A.J.M.; Moreira, P.I.; Custódio, J.B.A.; Santos, M.S.. "Mechanism of inhibition of mitochondrial ATP synthase by 17ß-Estradiol". Journal of Bioenergetics and Biomembranes 45 3 (2013): 261-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878642515&partnerID=MN8TOARS. 10.1007/s10863-012-9497-1 Correia, S.C.; Santos, R.X.; Santos, M.S.; Casadesus, G.; LaManna, J.C.; Perry, G.; Smith, M.A.; Moreira, P.I.. "Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease". Current Alzheimer Research 10 4 (2013): 406-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878623135&partnerID=MN8TOARS. 10.2174/1567205011310040006 Santos, R.X.; Correia, S.C.; Zhu, X.; Smith, M.A.; Moreira, P.I.; Castellani, R.J.; Nunomura, A.; Perry, G.. "Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease". Antioxidants and Redox Signaling 18 18 (2013): 2444-2457. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878619863&partnerID=MN8TOARS. 10.1089/ars.2012.5039 Perry, E.A.; Castellani, R.J.; Moreira, P.I.; Nunomura, A.; Lui, Q.; Harris, P.L.R.; Sayre, L.M.; et al. "Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links". Free Radical Research 47 6-7 (2013): 507-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878875361&partnerID=MN8TOARS. 10.3109/10715762.2013.794265 Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.; et al. "Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 4 (2013): 527-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873306844&partnerID=MN8TOARS. 10.1016/j.bbadis.2013.01.008 Cardoso, S.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I.. "Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins". Current Molecular Medicine 13 4 (2013): 586-601. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876735551&partnerID=MN8TOARS. 10.2174/1566524011313040010 Alves, M.G.; Martins, A.D.; Rato, L.; Moreira, P.I.; Socorro, S.; Oliveira, P.F.. "Molecular mechanisms beyond glucose transport in diabetes-related male infertility". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 5 (2013): 626-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874414576&partnerID=MN8TOARS. 10.1016/j.bbadis.2013.01.011 González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P.. "Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp. in response to the deleterious changes induced by H 2O2". Journal of Natural Products 76 5 (2013): 933-938. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878260967&partnerID=MN8TOARS. 10.1021/np400118d Cardoso, S.; Santos, R.X.; Correia, S.C.; Carvalho, C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Moreira, P.I.. "Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance". Neurobiology of Disease 49 1 (2013): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866491588&partnerID=MN8TOARS. 10.1016/j.nbd.2012.08.008 Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I.. "Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an Iffy question!". Current Pharmaceutical Design 19 38 (2013): 6809-6822. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884829985&partnerID=MN8TOARS. Candeias, E.; Duarte, A.I.; Carvalho, C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Perry, G.; Moreira, P.I.. "The impairment of insulin signaling in Alzheimer's disease". IUBMB Life 64 12 (2012): 951-957. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870197271&partnerID=MN8TOARS. 10.1002/iub.1098 Alves, M.G.; Oliveira, P.F.; Socorro, S.; Moreira, P.I.. "Impact of diabetes in blood-testis and blood-brain barriers: Resemblances and differences". Current Diabetes Reviews 8 6 (2012): 401-412. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870183874&partnerID=MN8TOARS. 10.2174/157339912803529896 Vaz, C.V.; Alves, M.G.; Marques, R.; Moreira, P.I.; Oliveira, P.F.; Maia, C.J.; Socorro, S.. "Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile". International Journal of Biochemistry and Cell Biology 44 11 (2012): 2077-2084. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865554409&partnerID=MN8TOARS. 10.1016/j.biocel.2012.08.013 Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I.. "Alzheimer disease as a vascular disorder: Where do mitochondria fit?". Experimental Gerontology 47 11 (2012): 878-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867725518&partnerID=MN8TOARS. 10.1016/j.exger.2012.07.006 Marques-Aleixo, I.; Oliveira, P.J.; Moreira, P.I.; Magalhães, J.; Ascensão, A.. "Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms". Progress in Neurobiology 99 2 (2012): 149-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867896217&partnerID=MN8TOARS. 10.1016/j.pneurobio.2012.08.002 Duarte, A.I.; Moreira, P.I.; Oliveira, C.R.. "Insulin in central nervous system: More than just a peripheral hormone". Journal of Aging Research 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868282388&partnerID=MN8TOARS. 10.1155/2012/384017 Carvalho, C.; Cardoso, S.; Correia, S.C.; Santos, R.X.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Moreira, P.I.. "Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities". Diabetes 61 5 (2012): 1234-1242. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860599622&partnerID=MN8TOARS. 10.2337/db11-1186 Moreira, P.I.. "Alzheimer's disease and diabetes: An integrative view of the role of mitochondria, oxidative stress, and insulin". Journal of Alzheimer's Disease 30 SUPPL.2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863002103&partnerID=MN8TOARS. 10.3233/JAD-2011-111127 Mondragón-Rodríguez, S.; Perry, G.; Zhu, X.; Moreira, P.I.; Williams, S.. "Glycogen synthase kinase 3: A point of integration in alzheimer's disease and a therapeutic target?". International Journal of Alzheimer's Disease (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863697825&partnerID=MN8TOARS. 10.1155/2012/276803 Nunomura, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G.. "Oxidative damage to RNA in aging and neurodegenerative disorders". Neurotoxicity Research 22 3 (2012): 231-248. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865407887&partnerID=MN8TOARS. 10.1007/s12640-012-9331-x Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Candeias, E.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation". Brain Research 1441 (2012): 64-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857788978&partnerID=MN8TOARS. 10.1016/j.brainres.2011.12.063 Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy". Autophagy 8 4 (2012): 445-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS. 10.4161/auto.19496 Santos, R.X.; Correia, S.C.; Zhu, X.; Lee, H.-G.; Petersen, R.B.; Nunomura, A.; Smith, M.A.; Perry, G.; Moreira, P.I.. "Nuclear and mitochondrial DNA oxidation in Alzheimer's disease". Free Radical Research 46 4 (2012): 565-576. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863229887&partnerID=MN8TOARS. 10.3109/10715762.2011.648188 Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A.. "Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases". Advances in Experimental Medicine and Biology 724 (2012): 205-221. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859514171&partnerID=MN8TOARS. 10.1007/978-1-4614-0653-2_16 Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a". Neurobiology of Disease 45 1 (2012): 206-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS. 10.1016/j.nbd.2011.08.005 Zhu, X.; Castellani, R.J.; Moreira, P.I.; Aliev, G.; Shenk, J.C.; Siedlak, S.L.; Harris, P.L.R.; et al. "Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover". Free Radical Biology and Medicine 52 3 (2012): 699-704. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856283539&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2011.11.004 Castellani, R.J.; Moreira, P.I.; Perry, G.; Zhu, X.. "The role of iron as a mediator of oxidative stress in Alzheimer disease". BioFactors 38 2 (2012): 133-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862817976&partnerID=MN8TOARS. 10.1002/biof.1010 Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al. "SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization". Cancer Cell 19 3 (2011): 416-428. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS. 10.1016/j.ccr.2011.02.014 Moreira, P.I.; Oliveira, C.R.. "Mitochondria as potential targets in antidiabetic therapy". Handbook of Experimental Pharmacology 203 (2011): 331-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955615960&partnerID=MN8TOARS. 10.1007/978-3-642-17214-4-14 Cardoso, S.; Carvalho, C.; Santos, R.; Correia, S.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I.. "Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters". Synapse 65 6 (2011): 457-466. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953276927&partnerID=MN8TOARS. 10.1002/syn.20863 Santos, R.X.; Correia, S.C.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I.. "Effects of rapamycin and TOR on aging and memory: Implications for Alzheimer's disease". Journal of Neurochemistry 117 6 (2011): 927-936. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957971392&partnerID=MN8TOARS. 10.1111/j.1471-4159.2011.07262.x Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Oliveira, P.J.; Moreno, A.; Seia, R.; Oliveira, C.R.; Santos, M.S.. "Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen". Journal of Steroid Biochemistry and Molecular Biology 123 1-2 (2011): 8-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650578395&partnerID=MN8TOARS. 10.1016/j.jsbmb.2010.09.004 Perry, G.; Smith, M.A.; Casadesus, G.; Lee, H.-G.; Moreira, P.I.; Castellani, R.J.; Zhu, X.. "Using biology to untie the Gordian knot of Alzheimer's disease". Journal of Alzheimer's Disease 23 SUPPL. 1 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952176838&partnerID=MN8TOARS. 10.3233/JAD-2011-001433 Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Association of mitochondrial signaling in Alzheimer's disease and hypoxia". Molecular Aspects of Neurodegeneration and Neuroprotection (2011): 50-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884443449&partnerID=MN8TOARS. 10.2174/978160805092511101010050 Santos, R.X.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Mitophagy in neurodegeneration: An opportunity for therapy?". Current Drug Targets 12 6 (2011): 790-799. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955585040&partnerID=MN8TOARS. 10.2174/138945011795528813 Collins, G.H.; Mondragón-Rodríguez, S.; Nunomura, A.; Zhu, X.; Moreira, P.I.; Smith, M.A.. "Oxidative Stress and Balance in Neurodegenerative Diseases". Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition (2011): 10-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886036204&partnerID=MN8TOARS. 10.1002/9781444341256.ch3 Liu, Q.; Xie, F.; Alvarado-Diaz, A.; Smith, M.A.; Moreira, P.I.; Zhu, X.; Perry, G.. "Neurofilamentopathy in neurodegenerative diseases". Open Neurology Journal 5 1 (2011): 58-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053515856&partnerID=MN8TOARS. 10.2174/1874205X01105010058 Correia, S.C.; Cardoso, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Perry, G.; Smith, M.A.; Moreira, P.I.. "New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection". Current Pharmaceutical Design 17 31 (2011): 3381-3389. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055089996&partnerID=MN8TOARS. 10.2174/138161211798072490 Moreira, P.I.. "Mitochondrial dysfunction and oxidative stress in Alzheimer's disease". European Neurological Review 5 1 (2010): 17-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858166678&partnerID=MN8TOARS. Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.; Castellani, R.J.. "Alzheimer's Disease: An Overview". Encyclopedia of Neuroscience (2010): 259-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882903387&partnerID=MN8TOARS. 10.1016/B978-008045046-9.00544-1 Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X.. "A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease". Journal of Alzheimer's Disease 20 SUPPL.2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956199031&partnerID=MN8TOARS. 10.3233/JAD-2010-100666 Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A.. "Mitochondria: The missing link between preconditioning and neuroprotection". Journal of Alzheimer's Disease 20 SUPPL.2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956220265&partnerID=MN8TOARS. 10.3233/JAD-2010-100669 Carvalho, C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I.. "Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes". Current Neurovascular Research 7 4 (2010): 288-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650657043&partnerID=MN8TOARS. Cardoso, S.; Santos, M.S.; Seiça, R.; Moreira, P.I.. "Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia". Biochimica et Biophysica Acta - Molecular Basis of Disease 1802 11 (2010): 942-951. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956710094&partnerID=MN8TOARS. 10.1016/j.bbadis.2010.07.001 Santos, R.X.; Cardoso, S.; Correia, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I.. "Targeting autophagy in the brain: A promising approach?". Central Nervous System Agents in Medicinal Chemistry 10 2 (2010): 158-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953681716&partnerID=MN8TOARS. Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Effects of estrogen in the brain: Is it a neuroprotective agent in alzheimer's disease?". Current Aging Science 3 2 (2010): 113-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953736213&partnerID=MN8TOARS. 10.2174/1874609811003020113 Moreira, P.I.; Santos, R.X.; Zhu, X.; Lee, H.-G.; Smith, M.A.; Casadesus, G.; Perry, G.. "Autophagy in Alzheimers disease". Expert Review of Neurotherapeutics 10 7 (2010): 1209-1218. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954196784&partnerID=MN8TOARS. 10.1586/ern.10.84 Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X.. "Alzheimer's disease: Diverse aspects of mitochondrial malfunctioning". International Journal of Clinical and Experimental Pathology 3 6 (2010): 570-581. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956026971&partnerID=MN8TOARS. Moreira, P.I.; Zhu, X.; Wang, X.; Lee, H.-g.; Nunomura, A.; Petersen, R.B.; Perry, G.; Smith, M.A.. "Mitochondria: A therapeutic target in neurodegeneration". Biochimica et Biophysica Acta - Molecular Basis of Disease 1802 1 (2010): 212-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-71849088759&partnerID=MN8TOARS. 10.1016/j.bbadis.2009.10.007 Correia, S.C.; Moreira, P.I.. "Hypoxia-inducible factor 1: A new hope to counteract neurodegeneration?". Journal of Neurochemistry 112 1 (2010): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649085107&partnerID=MN8TOARS. 10.1111/j.1471-4159.2009.06443.x Moreira, P.I.; Sayre, L.M.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G.. "Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.". Methods in molecular biology (Clifton, N.J.) 610 (2010): 419-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-77449159407&partnerID=MN8TOARS. Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R.. "Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease". Experimental Neurology 223 2 (2010): 294-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS. 10.1016/j.expneurol.2009.06.008 Moreira, P.I.; Carvalho, C.; Zhu, X.; Smith, M.A.; Perry, G.. "Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology". Biochimica et Biophysica Acta - Molecular Basis of Disease 1802 1 (2010): 2-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749121998&partnerID=MN8TOARS. 10.1016/j.bbadis.2009.10.006 Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al. "Mitochondrial preconditioning: A potential neuroprotective strategy". Frontiers in Aging Neuroscience 2 AUG (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955962818&partnerID=MN8TOARS. 10.3389/fnagi.2010.00138 Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R.. "Mitochondria as a therapeutic target in Alzheimer's disease and diabetes". CNS and Neurological Disorders - Drug Targets 8 6 (2009): 492-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS. 10.2174/187152709789824651 Cardoso, S.; Correia, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al. "Insulin is a two-edged knife on the brain". Journal of Alzheimer's Disease 18 3 (2009): 483-507. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249106915&partnerID=MN8TOARS. Perry, G.; Moreira, P.I.; Siedlak, S.L.; Nunomura, A.; Zhu, X.; Smith, M.A.. "Natural oxidant balance in Parkinson disease". Archives of Neurology 66 12 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-73549092919&partnerID=MN8TOARS. 10.1001/archneurol.2009.261 Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Rego, A.C.; Oliveira, C.R.. "An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease". Journal of Alzheimer's Disease 16 4 (2009): 741-761. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649687039&partnerID=MN8TOARS. 10.3233/JAD-2009-0972 Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.; Oliveira, P.J.; Santos, M.S.; Moreira, P.I.. "Doxorubicin: The good, the bad and the ugly effect". Current Medicinal Chemistry 16 25 (2009): 3267-3285. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS. 10.2174/092986709788803312 Marlatt, M.W.; Moreira, P.I.; Lee, H.-g.; Casadesus, G.; Castellani, R.J.; Takeda, A.; Nunomura, A.; et al. "Therapeutic opportunities in Alzheimer disease: Current concepts". Frontiers in Medicinal Chemistry 4 1 (2009): 767-788. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880176698&partnerID=MN8TOARS. Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al. "Food deprivation promotes oxidative imbalance in rat brain". Journal of Food Science 74 1 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS. 10.1111/j.1750-3841.2008.00982.x Nunomura, A.; Hofer, T.; Moreira, P.I.; Castellani, R.J.; Smith, M.A.; Perry, G.. "RNA oxidation in Alzheimer disease and related neurodegenerative disorders". Acta Neuropathologica 118 1 (2009): 151-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349251839&partnerID=MN8TOARS. 10.1007/s00401-009-0508-1 Perry, G.; Xiongvei, Z.; Moreira, P.I.; Smith, M.A.. "Altered redox balance in disease: Can we change the new equilibria?". Annals of Neurology 65 2 (2009): 121-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549117802&partnerID=MN8TOARS. 10.1002/ana.21608 Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Clark, T.A.; Zhu, X.; Smith, M.A.; Perry, G.. "Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia". Journal of Bioenergetics and Biomembranes 41 5 (2009): 433-440. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449397210&partnerID=MN8TOARS. 10.1007/s10863-009-9247-1 Wang, X.; Su, B.; Siedlak, S.L.; Moreira, P.I.; Fujioka, H.; Wang, Y.; Casadesus, G.; Zhu, X.. "Amyloid-ß overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins". Proceedings of the National Academy of Sciences of the United States of America 105 49 (2008): 19318-19323. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049218922&partnerID=MN8TOARS. 10.1073/pnas.0804871105 Aliev, G.; Obrenovich, M.E.; Reddy, V.P.; Shenk, J.C.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G.. "Antioxidant therapy in Alzheimer's disease: theory and practice.". Mini reviews in medicinal chemistry 8 13 (2008): 1395-1406. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149374037&partnerID=MN8TOARS. 10.2174/138955708786369582 Correia, S.; Carvalho, C.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I.. "Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.". Mini reviews in medicinal chemistry 8 13 (2008): 1343-1354. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149377770&partnerID=MN8TOARS. 10.2174/138955708786369546 Cardoso, S.; Santos, R.X.; Carvalho, C.; Correia, S.; Pereira, G.C.; Pereira, S.S.; Oliveira, P.J.; et al. "Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage". Free Radical Biology and Medicine 45 10 (2008): 1395-1402. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349099428&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2008.08.008 Su, B.; Wang, X.; Nunomura, A.; Moreira, P.I.; Lee, H.-G.; Perry, G.; Smith, M.A.; Zhu, X.. "Oxidative stress signaling in Alzheimer's disease". Current Alzheimer Research 5 6 (2008): 525-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049202374&partnerID=MN8TOARS. 10.2174/156720508786898451 Moreira, P.I.; Nunomura, A.; Nakamura, M.; Takeda, A.; Shenk, J.C.; Aliev, G.; Smith, M.A.; Perry, G.. "Nucleic acid oxidation in Alzheimer disease". Free Radical Biology and Medicine 44 8 (2008): 1493-1505. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149166082&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2008.01.002 Castellani, R.J.; Nunomura, A.; Rolston, R.K.; Moreira, P.I.; Takeda, A.; Perry, G.; Smith, M.A.. "Sublethal RNA oxidation as a mechanism for neurodegenerative disease". International Journal of Molecular Sciences 9 5 (2008): 789-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649138016&partnerID=MN8TOARS. 10.3390/ijms9050789 Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R.. "Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease". Free Radical Biology and Medicine 44 12 (2008): 2051-2057. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2008.03.012 Correia, S.; Carvalho, C.; Santos, M.S.; Proença, T.; Nunes, E.; Duarte, A.I.; Monteiro, P.; et al. "Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes". Medicinal Chemistry 4 4 (2008): 358-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049125341&partnerID=MN8TOARS. 10.2174/157340608784872299 Carvalho, C.; Correia, S.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I.. "Metformin promotes isolated rat liver mitochondria impairment". Molecular and Cellular Biochemistry 308 1-2 (2008): 75-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-38649115973&partnerID=MN8TOARS. 10.1007/s11010-007-9614-3 Moreira, P.I.; Santos, M.S.; Oliveira, C.R.; Shenk, J.C.; Nunomura, A.; Smith, M.A.; Zhu, X.; Perry, G.. "Alzheimer disease and the role of free radicals in the pathogenesis of the disease". CNS and Neurological Disorders - Drug Targets 7 1 (2008): 3-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049116923&partnerID=MN8TOARS. 10.2174/187152708783885156 Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes". Autophagy 4 2 (2008): 151-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949108670&partnerID=MN8TOARS. Moreira, P.I.; Nunomura, A.; Honda, K.; Aliev, G.; Casadesus, G.; Zhu, X.; Smith, M.A.; Perry, G.. "The key role of oxidative stress in alzheimer's disease". Oxidative Stress and Neurodegenerative Disorders (2007): 267-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882487316&partnerID=MN8TOARS. 10.1016/B978-044452809-4/50153-8 Moreira, P.I.; Harris, P.L.R.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Smith, M.A.; Perry, G.. "Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts". Journal of Alzheimer's Disease 12 2 (2007): 195-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848890388&partnerID=MN8TOARS. Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al. "Erratum: Increased autophagic degradation of mitochondria in Alzheimer disease (Autophagy)". Autophagy 3 6 (2007): 614-615. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848931249&partnerID=MN8TOARS. Nunomura, A.; Moreira, P.I.; Takeda, A.; Smith, M.A.; Perry, G.. "Oxidative RNA damage and neurodegeneration". Current Medicinal Chemistry 14 28 (2007): 2968-2975. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849076772&partnerID=MN8TOARS. 10.2174/092986707782794078 Nunomura, A.; Moreira, P.I.; Lee, H.G.; Zhu, X.; Castellani, R.J.; Smith, M.A.; Perry, G.. "Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases". CNS and Neurological Disorders - Drug Targets 6 6 (2007): 411-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-41749088686&partnerID=MN8TOARS. 10.2174/187152707783399201 Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al. "Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532))". Journal of Neuropathology and Experimental Neurology 66 7 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34447321588&partnerID=MN8TOARS. 10.1097/01.jnen.0000263876.99435.cb Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.M.; Santos, M.S.; Matafome, P.; Moreira, P.I.; Seiça, R.. "Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets". Acta Diabetologica 44 3 (2007): 121-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548177719&partnerID=MN8TOARS. 10.1007/s00592-007-0252-8 Castellani, R.J.; Moreira, P.I.; Liu, G.; Dobson, J.; Perry, G.; Smith, M.A.; Zhu, X.. "Iron: The redox-active center of oxidative stress in Alzheimer disease". Neurochemical Research 32 10 (2007): 1640-1645. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548744723&partnerID=MN8TOARS. 10.1007/s11064-007-9360-7 Moreira, P.I.; Santos, M.S.; Oliveira, C.R.. "Alzheimer's disease: A lesson from mitochondrial dysfunction". Antioxidants and Redox Signaling 9 10 (2007): 1621-1630. http://www.scopus.com/inward/record.url?eid=2-s2.0-34648831384&partnerID=MN8TOARS. 10.1089/ars.2007.1703 Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Moreno, A.; Seiça, R.; Oliveira, C.R.; Santos, M.S.. "Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats". Toxicology and Applied Pharmacology 221 1 (2007): 102-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247869542&partnerID=MN8TOARS. 10.1016/j.taap.2007.02.006 Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al. "Autophagocytosis of mitochondria is prominent in Alzheimer disease". Journal of Neuropathology and Experimental Neurology 66 6 (2007): 525-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249881080&partnerID=MN8TOARS. 10.1097/01.jnen.0000240476.73532.b0 Moreira, P.I.; Santos, M.S.; Seiça, R.; Oliveira, C.R.. "Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes". Journal of the Neurological Sciences 257 1-2 (2007): 206-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249821079&partnerID=MN8TOARS. 10.1016/j.jns.2007.01.017 Zhu, X.; Smith, M.A.; Honda, K.; Aliev, G.; Moreira, P.I.; Nunomura, A.; Casadesus, G.; et al. "Vascular oxidative stress in Alzheimer disease". Journal of the Neurological Sciences 257 1-2 (2007): 240-246. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249776958&partnerID=MN8TOARS. 10.1016/j.jns.2007.01.039 Liu, Q.; Xie, F.; Rolston, R.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G.. "Prevention and treatment of Alzheimer disease and aging: Antioxidants". Mini-Reviews in Medicinal Chemistry 7 2 (2007): 171-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847776693&partnerID=MN8TOARS. 10.2174/138955707779802552 Casadesus, G.; Moreira, P.I.; Nunomura, A.; Siedlak, S.L.; Bligh-Glover, W.; Balraj, E.; Petot, G.; Smith, M.A.; Perry, G.. "Indices of metabolic dysfunction and oxidative stress". Neurochemical Research 32 4-5 (2007): 717-722. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947593456&partnerID=MN8TOARS. 10.1007/s11064-007-9296-y Castellani, R.J.; Zhu, X.; Lee, H.-G.; Moreira, P.I.; Perry, G.; Smith, M.A.. "Neuropathology and treatment of Alzheimer disease: Did we lose the forest for the trees?". Expert Review of Neurotherapeutics 7 5 (2007): 473-485. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248326079&partnerID=MN8TOARS. 10.1586/14737175.7.5.473 Nunomura, A.; Castellani, R.J.; Lee, H.G.; Moreira, P.I.; Zhu, X.; Perry, G.; Smith, M.A.. "Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.". Science of aging knowledge environment : SAGE KE 2006 8 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33744531637&partnerID=MN8TOARS. 10.1126/sageke.2006.8.pe10 Moreira, P.I.; Zhu, X.; Lee, H.-G.; Honda, K.; Smith, M.A.; Perry, G.. "The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease". Mechanisms of Ageing and Development 127 6 (2006): 501-506. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646160622&partnerID=MN8TOARS. 10.1016/j.mad.2006.01.024 Nunomura, A.; Castellani, R.J.; Zhu, X.; Moreira, P.I.; Perry, G.; Smith, M.A.. "Involvement of oxidative stress in Alzheimer disease". Journal of Neuropathology and Experimental Neurology 65 7 (2006): 631-641. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747861696&partnerID=MN8TOARS. 10.1097/01.jnen.0000228136.58062.bf Franco, S.; Blasco, M.A.; Siedlak, S.L.; Harris, P.L.R.; Moreira, P.I.; Perry, G.; Smith, M.A.. "Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?". Alzheimer's and Dementia 2 3 (2006): 164-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744931650&partnerID=MN8TOARS. 10.1016/j.jalz.2006.03.001 Moreira, P.I.; Honda, K.; Zhu, X.; Nunomura, A.; Casadesus, G.; Smith, M.A.; Perry, G.. "Brain and brawn: Parallels in oxidative strength". Neurology 66 2 SUPPL. 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33644850568&partnerID=MN8TOARS. Zhu, X.; Lee, H.-G.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Presenilin mutation: A deadly first hit in Alzheimer disease - A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"". Free Radical Biology and Medicine 40 5 (2006): 737-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644659794&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2005.12.028 Moreira, P.I.; Custódio, J.; Moreno, A.; Oliveira, C.R.; Santos, M.S.. "Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure". Journal of Biological Chemistry 281 15 (2006): 10143-10152. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744518169&partnerID=MN8TOARS. 10.1074/jbc.M510249200 Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S.. "Insulin attenuates diabetes-related mitochondrial alterations: A comparative study". Medicinal Chemistry 2 3 (2006): 299-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS. 10.2174/157340606776930754 Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.. "The key role of mitochondria in Alzheimer's disease". Journal of Alzheimer's Disease 9 2 (2006): 101-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS. Moreira, P.I.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G.. "Therapeutic options in Alzheimer's disease". Expert Review of Neurotherapeutics 6 6 (2006): 897-910. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745486884&partnerID=MN8TOARS. 10.1586/14737175.6.6.897 Zhu, X.; Perry, G.; Moreira, P.I.; Aliev, G.; Cash, A.D.; Hirai, K.; Smith, M.A.. "Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease". Journal of Alzheimer's Disease 9 2 (2006): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746089859&partnerID=MN8TOARS. Moreira, P.I.; Oliveira, C.. "Foreword: Mitochondria in Alzheimer disease". Journal of Alzheimer's Disease 9 2 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33746065622&partnerID=MN8TOARS. Moreira, P.I.; Zhu, X.; Liu, Q.; Honda, K.; Siedlak, S.L.; Harris, P.L.; Smith, M.A.; Perry, G.. "Compensatory responses induced by oxidative stress in Alzheimer disease". Biological Research 39 1 (2006): 7-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745840777&partnerID=MN8TOARS. Honda, K.; Moreira, P.I.; Liu, Q.; Siedlak, S.L.; Zhu, X.; Smith, M.A.; Perry, G.. "Redox active iron at the center of oxidative stress in Alzheimer disease". Letters in Drug Design and Discovery 2 6 (2005): 479-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744432930&partnerID=MN8TOARS. 10.2174/1570180054771545 Moreira, P.I.; Honda, K.; Liu, Q.; Santos, M.S.; Oliveira, C.R.; Aliev, G.; Nunomura, A.; et al. "Oxidative stress: The old enemy in Alzheimer's disease pathophysiology". Current Alzheimer Research 2 4 (2005): 403-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-24644443839&partnerID=MN8TOARS. 10.2174/156720505774330537 Moreira, P.I.; Santos, M.S.; Sena, C.; Nunes, E.; Seiça, R.; Oliveira, C.R.. "CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats". Experimental Neurology 196 1 (2005): 112-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244447857&partnerID=MN8TOARS. 10.1016/j.expneurol.2005.07.012 Sayre, L.M.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Metal ions and oxidative protein modification in neurological disease". Annali dell'Istituto Superiore di Sanita 41 2 (2005): 143-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-31644435822&partnerID=MN8TOARS. Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.. "Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 383-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS. 10.2174/1568007054546117 Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Castellani, R.J.; Perry, G.. "Oxidative stress and neurodegeneration". Annals of the New York Academy of Sciences 1043 (2005): 545-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744439419&partnerID=MN8TOARS. 10.1196/annals.1333.062 Petersen, R.B.; Siedlak, S.L.; Lee, H.-G.; Kim, Y.-S.; Nunomura, A.; Tagliavini, F.; Ghetti, B.; et al. "Redox metals and oxidative abnormalities in human prion diseases". Acta Neuropathologica 110 3 (2005): 232-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444549058&partnerID=MN8TOARS. 10.1007/s00401-005-1034-4 Zhu, X.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Alzheimer's disease: An intracellular movement disorder?". Trends in Molecular Medicine 11 9 (2005): 391-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344483065&partnerID=MN8TOARS. 10.1016/j.molmed.2005.07.002 Marlatt, M.W.; Webber, K.M.; Moreira, P.I.; Lee, H.-G.; Casadesus, G.; Honda, K.; Zhu, X.; Perry, G.; Smith, M.A.. "Therapeutic opportunities in Alzheimer Disease: One for all or all for one?". Current Medicinal Chemistry 12 10 (2005): 1137-1147. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544380930&partnerID=MN8TOARS. 10.2174/0929867053764644 Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G.. "Oxidative stress mechanisms and potential therapeutics in Alzheimer disease". Journal of Neural Transmission 112 7 (2005): 921-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS. 10.1007/s00702-004-0242-8 Honda, K.; Smithi, M.A.; Zhu, X.; Baus, D.; Merrick, W.C.; Tartakoff, A.M.; Hattier, T.; et al. "Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron". Journal of Biological Chemistry 280 22 (2005): 20978-20986. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444383489&partnerID=MN8TOARS. 10.1074/jbc.M500526200 Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.. "Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS. 10.2174/1568007054546072 Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A.. "Tau phosphorylation in Alzheimer's disease: Pathogen or protector?". Trends in Molecular Medicine 11 4 (2005): 164-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS. 10.1016/j.molmed.2005.02.008 Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R.. "Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats". Neurobiology of Disease 18 3 (2005): 628-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS. 10.1016/j.nbd.2004.10.017 Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G.. "A second look into the oxidant mechanisms in Alzheimer's disease". Current Neurovascular Research 2 2 (2005): 179-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS. 10.2174/1567202053586758 Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G.. "Chronological primacy of oxidative stress in Alzheimer disease". Neurobiology of Aging 26 5 (2005): 579-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2004.09.021 Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X.. "Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease". Journal of Neuroscience Research 79 4 (2005): 554-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS. 10.1002/jnr.20380 Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen". Neuropharmacology 48 3 (2005): 435-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844275276&partnerID=MN8TOARS. 10.1016/j.neuropharm.2004.10.012 Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G.. "Alzheimer's disease and oxidative stress: The old problem remains unsolved". Current Medicinal Chemistry - Central Nervous System Agents 5 1 (2005): 51-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS. Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al. "Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations". Free Radical Biology and Medicine 38 6 (2005): 746-754. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2004.11.005 Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G.. "Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?". Drug News and Perspectives 18 1 (2005): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS. 10.1358/dnp.2005.18.1.877165 Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Staying connected: Synapses in alzheimer disease". American Journal of Pathology 165 5 (2004): 1461-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS. Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G.. "Therapeutic potential of oxidant mechanisms in Alzheimer's disease". Expert Review of Neurotherapeutics 4 6 (2004): 995-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS. 10.1586/14737175.4.6.995 Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G.. "Neurofilament proteins in neurodegenerative diseases". Cellular and Molecular Life Sciences 61 24 (2004): 3057-3075. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS. 10.1007/s00018-004-4268-8 Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R.. "Effect of streptozotocin-induced diabetes on rat brain mitochondria". Journal of Neuroendocrinology 16 1 (2004): 32-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS. 10.1111/j.1365-2826.2004.01107.x Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Hydroxytamoxifen protects against oxidative stress in brain mitochondria". Biochemical Pharmacology 68 1 (2004): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS. 10.1016/j.bcp.2004.03.019 Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R.. "Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure". Diabetes 52 6 (2003): 1449-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS. 10.2337/diabetes.52.6.1449 Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models \| Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS. Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C.. "Effect of amyloid ß-peptide on permeability transition pore: A comparative study". Journal of Neuroscience Research 69 2 (2002): 257-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS. 10.1002/jnr.10282 Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C.. "Amyloid ß-peptide promotes permeability transition pore in brain mitochondria". Bioscience Reports 21 6 (2001): 789-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS. 10.1023/A:1015536808304 Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R.. "Synaptosomal response to oxidative stress: Effect of vinpocetine". Free Radical Research 32 1 (2000): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS. Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS. Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS. 10.1006/exnr.1999.7270
Capítulo de livro	Carvalho, Cristina; Pires, Joana F.; Moreira, Paula I.; Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging, 359-384. Elsevier, 2023. 10.1016/b978-0-12-823761-8.00016-1 Cardoso, Susana; Moreira, Paula I.. Autor correspondente: Moreira, Paula I.. "Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update". In Redox Signaling and Biomarkers in Ageing, 147-183. Springer International Publishing, 2022. Publicado • 10.1007/978-3-030-84965-8_8 Moreira, PI; Sónia C. Correia. "Unraveling the Role of Mitochondria in Alzheimer's Disease". In Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach, 407. Oxford, Estados Unidos: Oxford University Press, USA, 2020. Publicado Cardoso, Susana; Moreira, Paula I.. "Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones". In Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases, 37-64. Elsevier, 2020. Publicado • 10.1016/bs.irn.2020.02.010 Carvalho, Cristina; Moreira, Paula I.. "Cognitive Impairment in Obesity and Diabetes". In Obesity and Diabetes, 399-414. Springer International Publishing, 2020. 10.1007/978-3-030-53370-0_29 Correia, S.C.; Moreira, P.I.. "Role of mitochondria in neurodegenerative diseases: The dark side of the "Energy factory"". 2018. Cardoso, S.M.; Correia, S.C.; Carvalho, C.; Moreira, P.I.. "Mitochondria in Alzheimer’s disease and diabetes-associated neurodegeneration: License to heal!". 2017. 10.1007/164_2017_3 Cardoso, S.; Seiça, R.; Moreira, P.I.. "Diabesity and brain energy metabolism: The case of alzheimer’s disease". 2017. 10.1007/978-3-319-63260-5_5 Castellani, R.J.; Correia, S.C.; Moreira, P.I.; Perry, G.. "Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria". 2016. 10.1016/B978-0-12-802173-6.00018-6 Correia, S.C.; Moreira, P.I.; Perry, G.. "Autophagy in alzheimer’s disease: A cleaning service out-of-order?". 2015. 10.1007/978-3-319-13939-5_7 Marques-Aleixo, I.; Santos-Alves, E.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Exercise-Induced Protection Against Aging and Neurodegenerative Diseases: Role of Redox- and Mitochondrial-Based Alterations". 2015. 10.1002/9781118840634.ch26 Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Impact of green tea (Camellia Sinensis L.) consumption in diabetes mellitus-induced neurodegeneration". 2015. Castellani, R.J.; Moreira, P.I.; Zhu, X.; Perry, G.. "Alzheimer's Disease: Pathology and Pathogenesis". 2014. 10.1016/B978-0-12-801238-3.00160-4 Santos, R.X.; Moreira, P.I.. "Mtor is a potential therapeutic target for alzheimer's disease". 2014. Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.C.; Moreira, P.I.. "Chronic hypoxia, type 2 diabetes and Alzheimer's disease: A dangerous triad". 2013. Duarte, A.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.I.; et al. "The Janus Face of Insulin in Brain". 2013. 10.1002/9781118395318.ch5 Cardoso, S.; Carvalho, C.; Correia, S.; Santos, R.X.; Santos, M.S.; Moreira, P.I.. "Mitochondrial uncoupling proteins - therapeutic targets in neurodegeneration?". 2011. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Diabetes, mitochondria and brain endothelium dysfunction: A dangerous triad for neurodegeneration?". 2011. Nunomura, A.; Takeda, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G.. "Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease". 2009. 10.1007/978-0-387-87995-6_9 Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Perry, G.. "The potential application of antioxidant agents in Alzheimer disease therapeutics". In Ageing research reviews. 2007. 10.1007/978-0-387-71522-3_12
Edição de número de revista	Moreira, PI; George Perry; Jesus Avila; Aaron Serensen; Massimo Tabaton. "Preface: Alzheimer's Disease: New Beginnings". Journal of Alzheimer s Disease 64 1 (2018): https://content.iospress.com/journals/journal-of-alzheimers-disease/64/s1. Publicado • 10.1111/nyas.1982.396.issue-1 Moreira, P.I.. "Mini-Symposium: Energy Demand and Energy Supply in Alzheimer’s Disease - Introduction". Brain Pathology 26 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988637950&partnerID=MN8TOARS. 10.1111/bpa.12398
Livro	Moreira, PI. Alzheimer's Disease: New Beginnings. Países Baixos: IOS Press BV. 2018. Publicado • Editor
Poster em conferência	Moreira, PI. "Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer's disease: a longitudinal in vivo multimodal study". Trabalho apresentado em ARVO Annual Meeting, 2019.
Resumo em conferência	C Carvalho, SC Correia, S Cardoso, PI Moreira. Untangling the protective role of Zfra 1-31 peptide against type 2 diabet. "Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Bari, 2022. Publicado Moreira, PI; Carvalho, Cristina. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Trabalho apresentado em 57th Annual Meeting of the European Association for the Study of Diabetes 2021 - EASD2021, 2021. Publicado Cardoso, Susana; Diano, Sabrina; Moreira, PI. "UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults.". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado T Fernandes; R Resende; MR Domingues; Moreira, PI; C Pereira. "Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado D Mena; IN Alves; DF Silva; E Candeias; CR Oliveira,; R Seiça; PF Monteiro; Moreira, PI; AI Duarte. "The Neuroprotection by GLP-1 Receptor Agonists in High Cardiovascular risk and Neurodegenerative Diseases". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado S Correia; M Alves; P Oliveira; G Casadesus; G Perry; Moreira, PI. "Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: A" breath of fresh air" towards effective treatment?". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado Moreira, PI; C Carvalho. "WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado C Carvalho; C Martin; Moreira, PI. "N epsilon-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado D Franco da Silva; MI Alves; D Mena; D Vaz; PF Monteiro; Moreira, PI; AI Duarte. "The neuroprotective effects of peripheral treatment with Evolocumab in middle-aged rat at high cardiovascular risk". Trabalho apresentado em European Society for Clinical Investigation (ESCI) 2020: Utrecht, NL, Utrecht, 2020. Publicado D Mena; MI Alves; DF Silva; D Vaz; E Candeias; CR Oliveira; PF Monteiro; Moreira, PI; AI Duarte. "Diet-induced high cardiovascular risk compromises brain hippocampal metabolism and long-term spatial memory in middle-aged male rats". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020. Publicado D Mena; MI Alves; M Sjogren; DF Silva; CR Oliveira; Moreira, PI; M Bjorkqvist; AI Duarte. "Co-administration of liraglutide and ghrelin ameliorates brain mitochondrial energy metabolism in the R6/2 mouse model for Huntington's disease". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020. Publicado MI Alves; D Mena; DF Silva; R Seica; CR Oliveira; AI Duarte; Moreira, PI. "Type 2 diabetes mitigates brain cortical energy metabolism in middle-aged female rats". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020. Publicado
Tese / Dissertação	Moreira, PI. "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties". Doutoramento, Universidade de Coimbra Faculdade de Medicina, 2007. http://hdl.handle.net/10316/7501. Moreira, PI. "Effect of the amyloid beta peptide on the permeability transition pore: a comparative study". Mestrado, Universidade de Coimbra - Faculdade de Ciências e Tecnologia, 2002.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/03/17	O inibidor da WWOX Zfra1-31 melhora a função cognitiva e a disfunção das mitocôndrias de cérebros de ratinhos com diabetes tipo 2	19th Meeting of Portuguese Society for Diabetes Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2023/01/25	WWOX: a new therapeutic target in Type 2 diabetes-associated neurodegeneration	DCV - Talks Universidade de Coimbra, Faculdade de Ciências e Tecnologia (Coimbra, Portugal)
2022/11/12	WWOX inhibition by Zfra1-31 ameliorates brain mitochondrial dysfunction and oxidative stress in a mouse model of type 2 diabetes	2nd International Meeting of the Portuguese Society of Physiology Sociedade Portuguesa de Fisiologia (Coimbra, Portugal)
2022/07/18	Metabolic Defects in Alzheimer's Disease	International Research Conference on Neurodegenerative Diseases Global Association for the Study of Neurodegenerative Diseases (Omaha, Estados Unidos)
2022/06/08	Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study	56th Annual Scientific Meeting European Society for Clinical Investigation European Society for Clinical Investigation (Bari, Itália)
2022/05/25	Diabetes and Alzheimer's disease crosstalk	Nova Medical School Seminars Faculdade de Ciências Médicas, Universidade Nova de Lisboa (Lisboa, Portugal)
2022/04/22	Impaired insulin and IGF-1 signaling affects brain mitochondria and redox homeostasis	Spanish Symposium on IGFs and Insulin 2022: Implications in Physiology and Disease (Logroño, Espanha)
2022/03/10	A inibição da proteína WWOX protege a mitocôndria e previne a morte de neurónios expostos a níveis elevados de glicose	18th Meeting of Portuguese Society for Diabetes Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2021/11/18	Structural and functional alterations in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease	2º Retiro do Grupo de Metabolismo, Envelhecimento e Doença (MAD) do Centro de Inovação em Biomedicina e Biotecnologia (CIBB) (Coimbra, Portugal)
2021/09/11	N-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells	55th Annual Scientific Meeting - ESCI Virtual 2021 European Society for Clinical Investigation
2021/07/27	Neuroprotective effect of Zfra 1-31 peptide against high glucose-induced mitochondrial dynamics and autophagy alterations	57th EASD Annual Meeting European Society for the study of diabetes 2021 European Association for the Study of Diabetes
2021/07/19	Zfra 1-31 prevents high glucose-induced neuronal death through improvement of mitochondrial and autophagy defects	International Conference on Diabetes and Endocrinology. Coalesce Research Group (Online)
2021/07/02	Alzheimer disease beyond amyloid: a preclinical perspective	35ª REUNIÃO ANUAL DO GEECD - Inovação em Doença de Alzheimer GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Coimbra, Portugal)
2021/06/10	Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: a "breath of fresh air"	55th Annual Scientific Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Online)
2021/06/09	Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model	55ª Reunião científica anual da Sociedade Europeia para a Investigação Clínica (ESCI) European Society for Clinical Investigation (Webinar)
2021/06/06	UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults	55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021 European Society for Clinical Investigation (On line)
2021/06/06	WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death	55th Annual Scientific Meeting - ESCI Virtual 2021 European Society for Clinical Investigation
2021/06/03	Loss of HUMMR as a potential 'roadblock' for mitochondrial movement in Alzheimer's disease	35th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar)
2021/04/26	Mitochondrial dysfunction and oxidative stress in Alzheimer's disease	Redox Webinar Series - Crosstalk between oxidative stress and metabolic defects: implications for Alzheimer's disease Faculty of Pharmacy and Medicine, Sapienza University of Rome (Rome, Itália)
2020/09/26	Hypoxic precoditioning averts sporadic Alzheimer's disease-like phenotype in rats: the role of mitochondrial remodeling	34th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Portugal)
2020/09/26	Structural and functional alterations in endoplasmic reticulum-mitochondria contacts in Alzheimer's disease in vitro models	34ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD) GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar, Portugal)
2020/02/06	Changes in the Protein Composition of Mitochondrial-Associated Membranes (MAMs) in Alzheimer's Disease	50ª Reunião da Sociedade Portuguesa de Farmacologia Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/05	Hypoxic preconditioning: a strategy to fight Alzheimer’s disease?	European Society of Clinical Investigation (Coimbra, Portugal)
2018/03	Mitochondrial dysfunction and energy failure in Alzheimer’s disease	Focused Symposium “Bioenergetics and neurodegenerative disorders: moving from pathogenesis to therapeutics”; Advances in Neuroscience for Medical Advance Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier (França)
2016/06/04	Alzheimer's disease: mechanistic insights and biomarkers discovery	30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (Lisboa, Portugal)
2016	Alzheimer's disease: focus on mitochondria	Seminars_IBILI (Coimbra, Portugal)
2015/10	The efficacy of the antidiabetic drug liraglutide in Alzheimer’s disease-like pathology	6th Annual Alliance for Healthy Ageing: Interventions to Slow Down Aging (Newcastle, Reino Unido)
2015/03	Insulin signaling as a bridge between diabetes and Alzheimer’s disease	Gordon Research Conference - IGF & Insulin System in Physiology & Disease (California, Estados Unidos)
2014/07	Mitochondria take center stage in Alzheimer’s disease	18th European BioEnergetics Conference – EBEC 2104 (Lisboa, Portugal)
2014/04	Etiologia e fisiopatologia das doenças neurodegenerativas	Ciclo de Palestras em Atividade Física e Saúde “Exercício, Saúde e Sociedade CIAFEL - Universidade do Porto (Porto, Portugal)
2014	A diabetes tipo 2 e a doença de Alzheimer	Jornadas de Análises Clínicas e Saúde Pública – Reunião Anual 2014 Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2013	Mitochondrial crossroad in Alzheimer’s disease	47th Annual Scientific Meeting of the European Society for Clinical Investigation (Albufeira, Portugal)
2011	Mitochondria and the Vasculature	7th International Congress on Vascular Dementia (Riga, Letónia)
2010/11/22	Alzheimer’s disease: research tools and therapeutic perspectives	Palestras do Núcleo de Estudantes de Bioquímica Núcleo de Estudantes de Bioquímica (Coimbra, Portugal)
2010/05/03	Mitochondria, diabetes and Alzheimer’s disease	Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration Universidade do Porto (Porto, Portugal)
2009/07	A disfunção mitocondrial na doença de Alzheimer	II Jornadas de Bioquímica da UTAD Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2008/07	A mitocôndria, um catalizador do envelhecimento cerebral e da demência	Ciência 2008 – Encontro com a Ciência em Portugal Promovido pelos Laboratórios Associados Fundação Calouste Gulbenkian (Lisboa, Portugal)
2007/11/08	Diabetes is a risk factor for Alzheimer disease: the role of mitochondria	5th International Congress on Vascular Dementia (Budapeste, Hungria)
2007/11	O papel da mitocôndria na doença de Alzheimer	1º Congresso Científico de Saúde: Doenças Neurodegenerativas Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2007/04/28	Liver mitochondria isolated from ovariectomized and tamoxifen-treated ovariectomized rat females are affected by estradiol	1st Iberic Meeting on Medicinal Chemistry: Anticancer Agents – 1IMMC (Régua, Portugal)
2006/12/08	Tamoxifen and estradiol: a deadly combination for cancer cells	XV National Congress of Biochemistry Sociedade Portuguesa de Bioquímica (Aveiro, Portugal)
2006/07	Mitochondrial autophagocytosis in Alzheimer disease	10th International Conference on Alzheimer´s Disease and Related Disorders (Madrid, Espanha)
2006/03	Tamoxifen and estradiol lead to mitochondrial complex I failure	International Courses on Toxicology “Smart Toxicology: Subcellular Targets of Anti-Cancer Therapy” Universidade de Coimbra, Centro de Neurociencias e Biologia Celular
2006	Oxidative Stress in Alzheimer disease: role of antioxidants	4th International Congress on the Improvement of the Quality of Life in Dementia, Epilepsy, MS and Peripheral Neuropathies (Odessa, Ucrânia)
2005/10	Brain mitochondria as a link between Alzheimer’s disease and diabetes	4th International Congress on Vascular Dementia (Porto, Portugal)
2005/07/03	Brain mitochondrial dysfunction is a common feature in both diabetes and Alzheimer’s disease	19ª Reunião do grupo de estudos do envelhecimento cerebral e demência (Tomar, Portugal)
2005/04	Effect of amyloid beta-peptide on brain mitochondria isolated from diabetic rats	Mitochondria: Between Life and Death – International Courses on Toxicology (Coimbra, Portugal)
2003/12/15	Diabetes and Alzheimer’s Disease: Are Brain Mitochondria a Link Between Both Pathologies?	1º Workshop de Bioquímica Clínica (Porto, Portugal)
2003/12	Role of Insulin in Brain Mitochondria Status of Type 1 Diabetic Rats. Does Amyloid beta-Peptide Interferes with Mitochondrial Function?	16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine
2002/07/14	Bioenergética mitocondrial e o envelhecimento	16ª Reunião-Grupo de Estudos – Envelhecimento Cerebral e Demência
2001	Mitochondria: a target for beta-amyloid peptide	XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica (Coimbra, Portugal)
2000/07/02	Mitocôndria e o envelhecimento: efeito do peptídeo Abeta25-35	14ª Reunião - Grupo de Estudos: Envelhecimento Cerebral e Demência

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023/04/03 - 2023/04/13	ONE HEALTH: A Metabolic Approach from the Cell to Society Advanced Course - PHD Programme in Experimental Biology and Biomedicine (2023) Outro (Coorganizador)	Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal
2022/04/04 - 2022/04/08	Advanced Course "Metabolic and inflammatory drivers in age-related neurodegenerative diseases" (2022/04/04) Outro (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/23 - 2019/05/24	Symposium - Neurobiology of Aging; 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019 - 2019) Simpósio	European Society for Clinical Investigation, Países Baixos
2019/04/08 - 2019/04/12	Advanced Course - Neurodegenerative Disorders PhD Programme in Experimental Biology and Biomedicine (2019 - 2019) Outro (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/02/25 - 2013/03/01	Advanced Course - Neurobiology and Disease Doctoral Programme in Health Sciences (2013 - 2013) Outro (Coorganizador)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2012/12/10 - 2012/12/14	Advanced Course - Biology of Proteolysis in Pathology; PhD Programme in Experimental Biology and Biomedicine (2012 - 2012) Outro (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2022/07/18 - 2022/07/18	Session chair - International Research Conference on Neurodegenerative Diseases Conferência	International Research Conference on Neurodegenerative Diseases

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2022/07/01 - 2022/07/02	36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2020/05 - Atual	Antioxidants & Redox Signaling (1557-7716)	Mary Ann Liebert
2018 - Atual	Journal of Alzheimer's Disease Reports	IOS Press
2018 - Atual	Diabetologia (1432-0428)	Springer-Verlag
2018 - Atual	Brain Behavior and Immunity (1090-2139)	Elsevier
2018 - Atual	Scientific Reports (2045-2322)	Springer Science and Business Media LLC
2018 - Atual	Cellular and Molecular Life Sciences (1420-9071)	Springer-Verlag
2018 - Atual	EClinicalMedicine (2589-5370)	Elsevier
2018 - Atual	Nature Reviews Neurology (1759-4766)	Springer Science and Business Media LLC
2018 - Atual	Neurotherapeutics (1878-7479)	Springer-Verlag
2017 - Atual	Progress in Neurobiology (0301-0082)	Elsevier
2017 - Atual	Alzheimers Disease & Dementia (2578-6490)	sPage.direcT
2017 - Atual	American Journal of Alzheimer s Disease (1082-5207)	SAGE Publications
2017 - Atual	Molecular Biology Reports (1573-4978)	Springer-Verlag
2016 - Atual	Rejuvenation Research (1557-8577)	Mary Ann Liebert
2016 - Atual	Diabetes Obesity and Metabolism (1463-1326)	Wiley (Blackwell Publishing)
2016 - Atual	Nature Reviews Endocrinology (1759-5037)	Springer Science and Business Media LLC
2016 - Atual	The Lancet Diabetes & Endocrinology (2213-8587)	Elsevier
2015 - Atual	PeerJ (2167-8359)	PeerJ
2015 - Atual	BioMed Research International (2314-6141)	Hindawi Limited
2015 - Atual	Current Alzheimer Research (1567-2050)	Bentham Science
2015 - Atual	Journal of Clinical Investigation (1558-8238)	American Society for Clinical Investigation
2015 - Atual	Medicinal Research Reviews (1098-1128)	Wiley (John Wiley & Sons)
2015 - Atual	Neuropathology and Applied Neurobiology (1365-2990)	Wiley (Blackwell Publishing)
2015 - Atual	Expert Opinion on Drug Discovery (1746-045X)	Informa UK (Taylor & Francis)
2015 - Atual	Molecular Neurobiology (0893-7648)	Springer-Verlag
2015 - Atual	Trends in Neurosciences (0166-2236)	Elsevier
2014 - Atual	Therapeutic Advances in Chronic Disease (2040-6231)	SAGE Publications
2014 - Atual	Neuropharmacology (0028-3908)	Elsevier
2014 - Atual	Aging Cell (1474-9728)	Wiley (Blackwell Publishing)
2014 - Atual	Trends in Biotechnology (0167-7799)	Elsevier
2013 - Atual	Expert Reviews in Molecular Medicine (1462-3994)	Cambridge University Press
2012 - Atual	Frontiers in Aging Neuroscience (1663-4365)	Frontiers Media SA
2012 - Atual	Diabetes
2012 - Atual	Neurobiology of Disease (1095-953X)	Elsevier
2012 - Atual	Neurobiology of Disease (1095-953X)	Elsevier
2012 - Atual	Free Radical Biology and Medicine (0891-5849)	Elsevier
2012 - Atual	Neuroendocrinology (1423-0194)	S. Karger AG
2012 - Atual	Biochemical Pharmacology (0006-2952)	Elsevier
2012 - Atual	Journal of Neurochemistry (1471-4159)	Wiley (Blackwell Publishing)
2010 - Atual	Journal of Alzheimer s Disease (1875-8908)	IOS Press
2010 - Atual	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439)	Elsevier
2010 - Atual	European Journal of Pharmacology (0014-2999)	Elsevier
2009 - Atual	Antioxidants & Redox Signaling (1557-7716)	Mary Ann Liebert
2009 - Atual	European Journal of Clinical Investigation (1365-2362)	Wiley (Blackwell Publishing)
2009 - Atual	Neurosciences (1658-3183)	Neurosciences
2008 - Atual	The FASEB Journal (1530-6860)	Federation of American Society for Experimental Biology
2005 - Atual	Experimental Neurology (1090-2430)	Elsevier
2004 - Atual	Expert Review of Neurotherapeutics (1744-8360)	Informa UK (Taylor & Francis)
2013 - 2019	British Journal of Pharmacology (1476-5381)	Wiley (Blackwell Publishing)

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2016 - Atual	Evaluator for European Science Foundation Avaliador	European Science Foundation, França
2021 - 2021	Evaluator of the reports submitted by Doctorate Researchers (Decreto-Lei n.º 57/2016) Avaliador	Faculty of Medicine, University of Coimbra, Portugal
2016 - 2021	Evaluator of the Marie Sklodowska-Curie Individual Fellowships (Life Sciences Panel) Avaliador	European Commission, Bélgica	European Commission
2016 - 2021	Evaluator of applications - Alzheimer's Association Research Grant Program Avaliador	Alzheimer's Association, Estados Unidos	Alzheimer's Association
2019/12 - 2020/12	Committee Member on Novo Nordisk Foundation Challenge Programme 2020 - Biomedicine and Health Sciences Avaliador	Novo Nordisk Fonden, Dinamarca	Novo Nordisk Fonden
2018 - 2018	Evaluator of applications within the call "What causes Brain Disease?" Avaliador	Lundbeckfonden, Dinamarca	Lundbeckfonden
2016 - 2018	Evaluator of applications submitted to ANR	Agence nationale de la recherche, França	Agence nationale de la recherche
2014 - 2015	Evaluator Post-Doctoral Fellowships (Experimental Biology and Biochemistry Panel) Avaliador	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal), Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020/05 - Atual	Fisiologia II	(Master Universitario)	Universidade de Cabo Verde, Cabo Verde
2012 - Atual	Fundamentos de Fisiologia II	Licenciatura em Química Medicinal (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/02 - Atual	Fisiologia Humana Geral	Mestrado Integrado em Medicina Dentária (Mestrado integrado)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2011 - Atual	Fundamentos de Fisiologia I	Licenciatura em Química Medicinal (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Atual	Fundamentos de Fisiologia II	Mestrado Integrado em Engenharia Biomédica (Mestrado integrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Atual	Fundamentos de Fisiologia I	Mestrado Integrado em Engenharia Biomédica (Mestrado integrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006/02 - Atual	Fisiologia II	(Mestrado integrado)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2005/12/01 - Atual	Fisiologia I	Mestrado Integrado em Medicina (Mestrado integrado)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2023/04/03 - 2023/04/13	PHD Programme in Experimental Biology and Biomedicine - PDBEB	ONE HEALTH: A Metabolic Approach from the Cell to Society (Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2007 - Atual	Portuguese Society of Diabetology	Membro
2007 - Atual	European Association for the Study of Diabetes	Membro
2006 - Atual	Portuguese Society for Neuroscience	Membro

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2022/07/18 - 2022/07/19	IRCND 2022 Long Range Planning Committee Membro
2019/05/22 - 2019/05/24	Scientific committee - 53rd Annual Meeting of the European Society for Clinical Investigation (ESCI) Membro	European Society for Clinical Investigation, Países Baixos
2018/07/13 - 2018/07/13	Scientific Committee - International Symposium; MitoPorto – Mitochondrial evolution, metabolism and disease Outro
2013/05/30 - 2013/06/01	Organizing committee - XIII Reunião da Sociedade Portuguesa de Neurociências Membro

Distinções

Prémio

2023	Rosalind Franklin Society Special Award in Science Rosalind Franklin Society , Estados Unidos Mary Ann Liebert Inc., Estados Unidos
2023	Honorable Mention Pedro Eurico Lisboa / SPD Sociedade Portuguesa de Diabetologia, Portugal
2017	Orlando Leitão Prize Sociedade Portuguesa de Neurologia, Portugal
2015	Mantero Belard Prize Santa Casa da Misericórdia de Lisboa, Portugal
2014	2nd prize for research project Sociedade Portuguesa de Diabetologia, Portugal
2013	Best Research Paper - Basic Science Universidade de Coimbra - Faculdade de Medicina, Portugal
2010	ASN Neuro Poster Prize American Society of Neurochemistry, Estados Unidos
2008	L'Oreal for Women in Science award L’Oreal Portugal , Portugal Comissão Nacional da UNESCO , Portugal Fundação para a Ciência e a Tecnologia, Portugal
2003	Stimulus to Research Prize Fundação Calouste Gulbenkian, Portugal
2003	Best Poster Prize Physiological Society, Reino Unido

Título

2022	Member of Global Association for the Study of Neurodegenerative Diseases
2021	Member of the Selection Committee Top 25 Outstanding Women Listeners 2021
2021	Member of Neurodegeneration Precision Medicine Initiative
2018	Member of the Dana Alliance for Brain Initiatives Dana Foundation, Estados Unidos
2018	Member of European Science Foundation (ESF) College of Expert Reviewers European Science Foundation, França

Outra distinção

2022	World's Top 2% Scientists 2022
2021	Expertscape World Expert in Mitochondria
2021	World's Top 2% Scientists 2021