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Paula I. Moreira received her PhD in Biomedical Sciences from University of Coimbra, Portugal, in 2007. Currently, she is Assistant Professor at the Faculty of Medicine and Principal Investigator at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. Moreira's group is interested in elucidating the role of energy metabolism, with an emphasis on mitochondria (energy, homeostasis and signals) and metabolic hormones-mediated signaling pathways in brain changes occurring in metabolic disorders (e.g. diabetes and obesity) and neurodegenerative diseases, particularly Alzheimer disease. We are also interested in clarifying the role of hypoxia and sex/gender in the neurodegenerative events that characterize these pathologies. Additionally, we are exploring the therapeutic potential of anti-diabetic drugs, metabolic hormones and mitochondrial modulators. To achieve our goals we use several experimental models such as isolated mitochondria, in vitro and in vivo models of disease and human samples. Moreira has published more than 225 scientific peer-reviewed scientific articles. She is deputy editor of Journal of Alzheimer's Disease, associate editor of Journal of Alzheimer's Disease Reports and Frontiers of Aging Neuroscience, section editor of BBA-Molecular Basis of Disease and belongs to the editorial board of Antioxidants and Redox Signaling and Aging Brain, among others.
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Identificação

Identificação pessoal

Nome completo
PAULA ISABEL DA SILVA MOREIRA

Nomes de citação

  • Moreira, Paula
  • Paula I. Moreira
  • Moreira, PI
  • Moreira, Paula Isabel

Identificadores de autor

Ciência ID
9C16-2F47-6D91
ORCID iD
0000-0001-5177-6747
AuthenticusID
R-000-E6F
Google Scholar ID
https://scholar.google.pt/citations?user=5JO6pzkAAAAJ&hl=pt-PT
Researcher Id
B-3608-2009

Endereços de correio eletrónico

  • pismoreira@gmail.com (Profissional)
  • pimoreira@fmed.uc.pt (Profissional)
  • venta@ci.uc.pt (Profissional)

Moradas

  • Pólo III, Pólo das Ciências da Saúde, 3000-548, Azinhaga de Santa Comba, Celas, Coimbra, Portugal (Profissional)
  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2007/07/16
Concluído
 Ciências Biomédicas (Doutoramento)
Especialização em Neurociências
Universidade de Coimbra - Faculdade de Medicina, Portugal
"Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties" (TESE/DISSERTAÇÃO)
 Aprovado com Distinção e Louvor, por unanimidade
2002/05/23
Concluído
 Biologia Celular (Mestrado)
Especialização em Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effect of Aß25-35 in the mitochondrial permeability transition pore: a comparative study " (TESE/DISSERTAÇÃO)
1998/07/09
Concluído
 Biologia (Licenciatura)
Especialização em Ramo Científico
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2007 - Atual Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2016 - Atual Professor Auxiliar (Docente Universitário) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015 Professor Auxiliar Convidado (Docente Universitário) University of Texas at San Antonio, Estados Unidos
University of Texas at San Antonio College of Sciences, Estados Unidos
2011 - 2015 Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
2005 - 2011 Assistente (Docente Universitário) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2022 - Atual Zfra 1-31: an early intervention in T2D-associated neurodegeneration
EXPL/MED-FSL/0033/2021
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Em curso
2020/02 - Atual Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism
SFRH/BD/148801/2019
Orientador
Universidade de Coimbra - Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Em curso
2023 - 2024 Exploring the therapeutic potential of mitochondrial uncouplers in the context of Alzheimer's disease
ERG2023
Mentor
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 European Society for Clinical Investigation
Em curso
2022 - 2023 An exploratory study of the gender-specific response to hypoxia in Alzheimer's disease
ERG2022
Mentor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Society for Clinical Investigation
Em curso
2022 - 2023 MitoBOOST v2.0 - Prova de Conceito para o Uso de Polifenóis Dirigidos à Mitocôndria para Tratar a Doença do Fígado Gordo Não-Alcoólico
MitoBOOST v2.0
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Em curso
2021 - 2022 Zfra 1-31 peptide as a new candidate to fight type 2 diabetes-associated brain damage: a pilot study
ERG 2021
Mentor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Society for Clinical Investigation
Em curso
2019/04/01 - 2022 Rational Drug Design of novel potent multifunctional agents for Alzheimer's Disease treatment
SFRH/BD/138460/2018
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído
2016/03/01 - 2019/03/31 Exploring the crosstalk of neuronal WWOX and mitochondria in type 2 diabetes-associated neurodegeneration
SFRH/BPD/107741/2015
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído
2016/07/01 - 2019/01/31 Unveiling the potential of HIF-1a as a biomarker and therapeutic target in Alzheimer’s disease
SFRH/BPD/109822/2015
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído
2017 - 2019 Unravelling the neuroprotective role of peripheral co-administration of liraglutide and ghrelin on brain and cognitive function in Huntington disease
SFRH/BPD/84473/2012
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2015 - 2018 Does habitual physical activity mitigates chemotherapy-induced cardiac and brain dysfunction in a mouse model of prostate cancer? Role of mitochondrial-mediated mechanisms
SFRH/BPD/108322/2015
Orientador
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal
Concluído
2015 - 2018 HDAC3 neurophysiology and drug targeting in neurodegeneration
SFRH/BPD/102259/2014
Orientador
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2014/05/01 - 2017 Mild mitochondrial uncoupling: exploring its protective effects against brain damage associated to insulin-induced hypoglycemic events in type 1 diabetes
SFRH/BPD/95770/2013
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2013/03/01 - 2016/06/30 Mitochondrial trafficking in Alzheimer’s disease and hypoxic preconditioning: unveiling the role of the hypoxia up-regulated mitochondrial movement regulator
SFRH/BPD/84163/2012
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído
2013 - 2016 IMPACT OF PERIPHERAL EXENDIN-4 THERAPY ON THE MOLECULAR MECHANISMS UNDERLYING DIFFERENTIAL GENDER-RELATED BRAIN FUNCTION IN LONG-TERM TYPE 2 DIABETES
SFRH/BPD/84473/2012
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído
2009/03 - 2013/02 Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria
SFRH/BD/43965/2008
Orientador
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído
2009/01/01 - 2012/12/31 DECIPHERING THE ROLE OF MITOCHONDRIA AND UNCOUPLING PROTEINS IN HYPOGLYCEMIA- AND/OR HYPERGLYCEMIA-INDUCED BRAIN INJURY
SFRH/BD/43968/2008
Orientador
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído
2008/03/01 - 2012/02/29 ROLE OF MITOCHONDRIA IN THE REGULATION OF THE TRANSCRIPTION FACTOR HYPOXIA-INDUCIBLE FACTOR-1 IN BRAIN ENDOTHELIUM: POTENTIAL PROTECTION AGAINST DIABETIC COMPLICATIONS
SFRH/BD/40702/2007
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2007 - 2010 Impact of aging and gender in diabetic brain metabolism, oxidative stress and inflammation: Is there a (protective) role for insulin therapy?
SFRH/BPD/26872/2006
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2002 - 2006 Mitocôndria e sua relação com o envelhecimento, a doença de Alzheimer e a diabetes: papel da proteína b-amilóide
SFRH/BD/5320/2001
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
2000 - 2002 Efeito do peptídeo beta-amilóide no poro de permeabilidade transitória da mitocôndria
PRAXIS XXI/BM/20952/1999
Bolseiro de Mestrado
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluído

Projeto

Designação Financiadores
2018 - 2022 The ups and downs of cellular stress: the MAMs hypothesis for Bipolar disorder pathophysiology
CENTRO-01-0145-FEDER-028214
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2019/07 - 2021/07 A Saúde no Saber
45-2019/478
Investigador
Ciência Viva, Portugal
Em curso
2017/01 - 2020 HealthyAging2020
HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323
Investigador
Comissão de Coordenação e Desenvolvimento Regional do Centro
2016/04/01 - 2019/12/31 Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos
SII&DT 3269 Drugs2CAD
Investigador
Universidade de Coimbra, Portugal
 Agência Nacional de Inovação, S.A.
Concluído
2018 - 2019 Brain protection by Evolocumab in individuals at high risk for cardiovascular disease: from bench to bedside
PEPITA2018
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra - Faculdade de Medicina
Concluído
2016 - 2018 Targeting huntingtin proteostasis and mitochondria to prevent neuronal dysfunction in Huntington's disease
PTDC/NEU-NMC/0412/2014
Investigador
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2018 The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression?
Prémio Mantero Belard 2015
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2014/03 - 2015/02 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
Provided by PTCRIS: 135805
135805
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2014 - 2015 Selenate and Reduction of Neurofibrillary Tangle Formation: Role of Selenoproteins
U54MD008149
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Institute on Minority Health and Health Disparities
Concluído
2013 - 2015 Mitochondrial Trafficking In Alzheimer Disease: Revealing the Role of HUMMR
NIRG-13-282387
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Alzheimer's Association
2013 - 2015 New Strategies to Manage Brain Diseases
CENTRO-07-ST24-FEDER-002002
Investigador
Programa Operacional Regional do Centro - Projecto Mais Centro
Concluído
2013 - 2014 Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role?
MOREIRA06JAN13
Investigador responsável
Faculty of Medicine, University of Coimbra
2010/04 - 2013/09 Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem.
108326
Provided by PTCRIS: 108326
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2013/08 Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease
110990
Provided by PTCRIS: 110990
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2010/04 - 2013/03 The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins
103325
Provided by PTCRIS: 103325
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2008/11 - 2012/03 A new route for endothelial dysfunction on diabetes: From phenotypes to molecules
67498
Provided by PTCRIS: 67498
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2012 Influence of gender on the molecular mechanisms underlying aging-related changes in diabetic brain: the impact of insulin therapy
PMADSC
Investigador responsável
Faculty of Medicine, University of Coimbra
2008 - 2010 Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs
III-45
Investigador responsável
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
 Institute for Interdisciplinary Research, University of Coimbra
Concluído
2008 - 2009 Da diabetes à demência: Explorando as vias de sinalização mediadas pela mitocôndria e suas proteínas desacopladoras
----
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2007 - 2009 Exploring the crosstalk between mitochondrial reactive oxygen species and the transcriptional factor hypoxia factor-1 in brain and retinal endothelium
------
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Foundation for the Study of Diabetes
Concluído
Produções

Publicações

Artigo em revista
  1. Tiago Sousa; Paula I. Moreira; Susana Cardoso. "Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease". Biomedicines (2023): https://doi.org/10.3390/biomedicines11092331.
    10.3390/biomedicines11092331
  2. Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R.. "Therapeutic potential of glutaminyl cyclases: Current status and emerging trends". Drug Discovery Today (2023): 103644. http://dx.doi.org/10.1016/j.drudis.2023.103644.
    10.1016/j.drudis.2023.103644
  3. Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease". Frontiers in Aging Neuroscience 15 (2023): http://dx.doi.org/10.3389/fnagi.2023.1161847.
    10.3389/fnagi.2023.1161847
  4. Batista, Ana; Guimarães, Pedro; Serranho, Pedro; Nunes, Ana; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; et al. "Retinal imaging in animal models: Searching for biomarkers of neurodegeneration". Frontiers in Ophthalmology 3 (2023): http://dx.doi.org/10.3389/fopht.2023.1156605.
    10.3389/fopht.2023.1156605
  5. Cristina Carvalho; Paula I. Moreira. "Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria". Current Opinion in Neurobiology (2023): https://doi.org/10.1016/j.conb.2023.102694.
    10.1016/j.conb.2023.102694
  6. Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases". Biology (2023): https://doi.org/10.3390/biology12030414.
    10.3390/biology12030414
  7. Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A.. "Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice". Free Radical Biology and Medicine 198 (2023): S5-S6. http://dx.doi.org/10.1016/j.freeradbiomed.2022.12.030.
    10.1016/j.freeradbiomed.2022.12.030
  8. Bernardes, Rui; Ghalati, Maryam; Ferreira, Hugo; Martins, João; Guimarães, Pedro; Moreira, Paula; Ambrósio, António; Castelo-Branco, Miguel; Serranho, Pedro. "Longitudinal OCT texture analysis to assess the retinal changes in the triple-transgenic mouse model of Alzheimer's disease". Acta Ophthalmologica 100 S275 (2022): http://dx.doi.org/10.1111/j.1755-3768.2022.0173.
    10.1111/j.1755-3768.2022.0173
  9. Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira. "WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04508-7.
    10.1007/s00018-022-04508-7
  10. Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Stage-independent biomarkers for Alzheimer’s disease from the living retina: an animal study". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18113-y.
    10.1038/s41598-022-18113-y
  11. Antónia Diniz; Marco G. Alves; Emanuel Candeias; Ana I. Duarte; Paula I. Moreira; Branca M. Silva; Pedro F. Oliveira; Luís Rato. "Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23168912.
    10.3390/ijms23168912
  12. Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.832195.
    10.3389/fnagi.2022.832195
  13. Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". Cellular and Molecular Life Sciences 79 4 (2022): http://dx.doi.org/10.1007/s00018-022-04211-7.
    10.1007/s00018-022-04211-7
  14. Correia, Sónia C.; Alves, Marco G.; Oliveira, Pedro F.; Casadesus, Gemma; LaManna, Joseph; Perry, George; Moreira, Paula I.. "Hypoxic preconditioning averts sporadic Alzheimer’s disease-like phenotype in rats: a focus on mitochondria". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2019.8007.
    10.1089/ars.2019.8007
  15. Susana Cardoso; Paula I. Moreira. "Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222413470.
    10.3390/ijms222413470
  16. Sónia C. Correia; Paula I. Moreira. "Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!". Cellular and Molecular Neurobiology (2021): https://doi.org/10.1007/s10571-021-01148-6.
    10.1007/s10571-021-01148-6
  17. Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease". Biomedicines 9 8 (2021): 881-881. https://doi.org/10.3390/biomedicines9080881.
    10.3390/biomedicines9080881
  18. Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease". Aging (2021): http://dx.doi.org/10.18632/aging.202916.
    10.18632/aging.202916
  19. Carvalho, Cristina; Moreira, Paula I.. "WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration". Metabolism 116 (2021): 154616. http://dx.doi.org/10.1016/j.metabol.2020.154616.
    10.1016/j.metabol.2020.154616
  20. Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira. "IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis". Biomedicines 9 2 (2021): 158-158. https://doi.org/10.3390/biomedicines9020158.
    10.3390/biomedicines9020158
  21. Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira. "Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease". International Journal of Molecular Sciences 22 1 (2021): 461-461. https://doi.org/10.3390/ijms22010461.
    10.3390/ijms22010461
  22. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  23. Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique. "PINK1/PARKIN signalling in neurodegeneration and neuroinflammation". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-01062-w.
    Publicado • 10.1186/s40478-020-01062-w
  24. Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al. "Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort". International Journal of Environmental Research and Public Health (2020): https://doi.org/10.3390/ijerph17176051.
    10.3390/ijerph17176051
  25. Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al. "Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing". Nature Reviews Drug Discovery (2020): http://dx.doi.org/10.1038/s41573-020-0072-x.
    10.1038/s41573-020-0072-x
  26. Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al. "Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 6 (2020): 165752. http://dx.doi.org/10.1016/j.bbadis.2020.165752.
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  205. Moreira, P.I.; Santos, M.S.; Sena, C.; Nunes, E.; Seiça, R.; Oliveira, C.R.. "CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats". Experimental Neurology 196 1 (2005): 112-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244447857&partnerID=MN8TOARS.
    10.1016/j.expneurol.2005.07.012
  206. Sayre, L.M.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Metal ions and oxidative protein modification in neurological disease". Annali dell'Istituto Superiore di Sanita 41 2 (2005): 143-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-31644435822&partnerID=MN8TOARS.
  207. Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.. "Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 383-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS.
    10.2174/1568007054546117
  208. Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Castellani, R.J.; Perry, G.. "Oxidative stress and neurodegeneration". Annals of the New York Academy of Sciences 1043 (2005): 545-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744439419&partnerID=MN8TOARS.
    10.1196/annals.1333.062
  209. Petersen, R.B.; Siedlak, S.L.; Lee, H.-G.; Kim, Y.-S.; Nunomura, A.; Tagliavini, F.; Ghetti, B.; et al. "Redox metals and oxidative abnormalities in human prion diseases". Acta Neuropathologica 110 3 (2005): 232-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444549058&partnerID=MN8TOARS.
    10.1007/s00401-005-1034-4
  210. Zhu, X.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Alzheimer's disease: An intracellular movement disorder?". Trends in Molecular Medicine 11 9 (2005): 391-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344483065&partnerID=MN8TOARS.
    10.1016/j.molmed.2005.07.002
  211. Marlatt, M.W.; Webber, K.M.; Moreira, P.I.; Lee, H.-G.; Casadesus, G.; Honda, K.; Zhu, X.; Perry, G.; Smith, M.A.. "Therapeutic opportunities in Alzheimer Disease: One for all or all for one?". Current Medicinal Chemistry 12 10 (2005): 1137-1147. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544380930&partnerID=MN8TOARS.
    10.2174/0929867053764644
  212. Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G.. "Oxidative stress mechanisms and potential therapeutics in Alzheimer disease". Journal of Neural Transmission 112 7 (2005): 921-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS.
    10.1007/s00702-004-0242-8
  213. Honda, K.; Smithi, M.A.; Zhu, X.; Baus, D.; Merrick, W.C.; Tartakoff, A.M.; Hattier, T.; et al. "Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron". Journal of Biological Chemistry 280 22 (2005): 20978-20986. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444383489&partnerID=MN8TOARS.
    10.1074/jbc.M500526200
  214. Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.. "Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS.
    10.2174/1568007054546072
  215. Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A.. "Tau phosphorylation in Alzheimer's disease: Pathogen or protector?". Trends in Molecular Medicine 11 4 (2005): 164-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS.
    10.1016/j.molmed.2005.02.008
  216. Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R.. "Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats". Neurobiology of Disease 18 3 (2005): 628-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS.
    10.1016/j.nbd.2004.10.017
  217. Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G.. "A second look into the oxidant mechanisms in Alzheimer's disease". Current Neurovascular Research 2 2 (2005): 179-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS.
    10.2174/1567202053586758
  218. Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G.. "Chronological primacy of oxidative stress in Alzheimer disease". Neurobiology of Aging 26 5 (2005): 579-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2004.09.021
  219. Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X.. "Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease". Journal of Neuroscience Research 79 4 (2005): 554-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS.
    10.1002/jnr.20380
  220. Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen". Neuropharmacology 48 3 (2005): 435-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844275276&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2004.10.012
  221. Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G.. "Alzheimer's disease and oxidative stress: The old problem remains unsolved". Current Medicinal Chemistry - Central Nervous System Agents 5 1 (2005): 51-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS.
  222. Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al. "Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations". Free Radical Biology and Medicine 38 6 (2005): 746-754. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2004.11.005
  223. Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G.. "Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?". Drug News and Perspectives 18 1 (2005): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS.
    10.1358/dnp.2005.18.1.877165
  224. Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Staying connected: Synapses in alzheimer disease". American Journal of Pathology 165 5 (2004): 1461-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS.
  225. Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G.. "Therapeutic potential of oxidant mechanisms in Alzheimer's disease". Expert Review of Neurotherapeutics 4 6 (2004): 995-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS.
    10.1586/14737175.4.6.995
  226. Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G.. "Neurofilament proteins in neurodegenerative diseases". Cellular and Molecular Life Sciences 61 24 (2004): 3057-3075. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS.
    10.1007/s00018-004-4268-8
  227. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R.. "Effect of streptozotocin-induced diabetes on rat brain mitochondria". Journal of Neuroendocrinology 16 1 (2004): 32-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS.
    10.1111/j.1365-2826.2004.01107.x
  228. Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Hydroxytamoxifen protects against oxidative stress in brain mitochondria". Biochemical Pharmacology 68 1 (2004): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS.
    10.1016/j.bcp.2004.03.019
  229. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R.. "Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure". Diabetes 52 6 (2003): 1449-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS.
    10.2337/diabetes.52.6.1449
  230. Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS.
  231. Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C.. "Effect of amyloid ß-peptide on permeability transition pore: A comparative study". Journal of Neuroscience Research 69 2 (2002): 257-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS.
    10.1002/jnr.10282
  232. Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C.. "Amyloid ß-peptide promotes permeability transition pore in brain mitochondria". Bioscience Reports 21 6 (2001): 789-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS.
    10.1023/A:1015536808304
  233. Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R.. "Synaptosomal response to oxidative stress: Effect of vinpocetine". Free Radical Research 32 1 (2000): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS.
  234. Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS.
  235. Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS.
    10.1006/exnr.1999.7270
Capítulo de livro
  1. Cardoso, Susana; Moreira, Paula I.. "Neuro-glia communication and glycolysis". In Glycolysis, 27-50. Elsevier, 2024.
    10.1016/b978-0-323-91704-9.00006-9
  2. Carvalho, Cristina; Pires, Joana F.; Moreira, Paula I.; Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging, 359-384. Elsevier, 2023.
    10.1016/b978-0-12-823761-8.00016-1
  3. Cardoso, Susana; Moreira, Paula I.. Autor correspondente: Moreira, Paula I.. "Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update". In Redox Signaling and Biomarkers in Ageing, 147-183. Springer International Publishing, 2022.
    Publicado • 10.1007/978-3-030-84965-8_8
  4. Moreira, PI; Sónia C. Correia. "Unraveling the Role of Mitochondria in Alzheimer's Disease". In Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach, 407. Oxford, Estados Unidos: Oxford University Press, USA, 2020.
    Publicado
  5. Cardoso, Susana; Moreira, Paula I.. "Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones". In Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases, 37-64. Elsevier, 2020.
    Publicado • 10.1016/bs.irn.2020.02.010
  6. Carvalho, Cristina; Moreira, Paula I.. "Cognitive Impairment in Obesity and Diabetes". In Obesity and Diabetes, 399-414. Springer International Publishing, 2020.
    10.1007/978-3-030-53370-0_29
  7. Correia, S.C.; Moreira, P.I.. "Role of mitochondria in neurodegenerative diseases: The dark side of the "Energy factory"". 2018.
  8. Cardoso, S.M.; Correia, S.C.; Carvalho, C.; Moreira, P.I.. "Mitochondria in Alzheimer’s disease and diabetes-associated neurodegeneration: License to heal!". 2017.
    10.1007/164_2017_3
  9. Cardoso, S.; Seiça, R.; Moreira, P.I.. "Diabesity and brain energy metabolism: The case of alzheimer’s disease". 2017.
    10.1007/978-3-319-63260-5_5
  10. Castellani, R.J.; Correia, S.C.; Moreira, P.I.; Perry, G.. "Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria". 2016.
    10.1016/B978-0-12-802173-6.00018-6
  11. Correia, S.C.; Moreira, P.I.; Perry, G.. "Autophagy in alzheimer’s disease: A cleaning service out-of-order?". 2015.
    10.1007/978-3-319-13939-5_7
  12. Marques-Aleixo, I.; Santos-Alves, E.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Exercise-Induced Protection Against Aging and Neurodegenerative Diseases: Role of Redox- and Mitochondrial-Based Alterations". 2015.
    10.1002/9781118840634.ch26
  13. Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Impact of green tea (Camellia Sinensis L.) consumption in diabetes mellitus-induced neurodegeneration". 2015.
  14. Castellani, R.J.; Moreira, P.I.; Zhu, X.; Perry, G.. "Alzheimer's Disease: Pathology and Pathogenesis". 2014.
    10.1016/B978-0-12-801238-3.00160-4
  15. Santos, R.X.; Moreira, P.I.. "Mtor is a potential therapeutic target for alzheimer's disease". 2014.
  16. Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.C.; Moreira, P.I.. "Chronic hypoxia, type 2 diabetes and Alzheimer's disease: A dangerous triad". 2013.
  17. Duarte, A.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.I.; et al. "The Janus Face of Insulin in Brain". 2013.
    10.1002/9781118395318.ch5
  18. Cardoso, S.; Carvalho, C.; Correia, S.; Santos, R.X.; Santos, M.S.; Moreira, P.I.. "Mitochondrial uncoupling proteins - therapeutic targets in neurodegeneration?". 2011.
  19. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Diabetes, mitochondria and brain endothelium dysfunction: A dangerous triad for neurodegeneration?". 2011.
  20. Nunomura, A.; Takeda, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G.. "Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease". 2009.
    10.1007/978-0-387-87995-6_9
  21. Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Perry, G.. "The potential application of antioxidant agents in Alzheimer disease therapeutics". In Ageing research reviews. 2007.
    10.1007/978-0-387-71522-3_12
Edição de número de revista
  1. Moreira, PI; George Perry; Jesus Avila; Aaron Serensen; Massimo Tabaton. "Preface: Alzheimer's Disease: New Beginnings". Journal of Alzheimer s Disease 64 1 (2018): https://content.iospress.com/journals/journal-of-alzheimers-disease/64/s1.
    Publicado • 10.1111/nyas.1982.396.issue-1
  2. Moreira, P.I.. "Mini-Symposium: Energy Demand and Energy Supply in Alzheimer’s Disease - Introduction". Brain Pathology 26 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988637950&partnerID=MN8TOARS.
    10.1111/bpa.12398
Livro
  1. Several. Alzheimer's Disease: New Beginnings. Países Baixos: IOS Press BV. 2018.
    Publicado • Editor
Poster em conferência
  1. Moreira, PI. "Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer's disease: a longitudinal in vivo multimodal study". Trabalho apresentado em ARVO Annual Meeting, 2019.
Resumo em conferência
  1. C Carvalho, SC Correia, S Cardoso, PI Moreira. Untangling the protective role of Zfra 1-31 peptide against type 2 diabet. "Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Bari, 2022.
    Publicado
  2. Moreira, PI; Carvalho, Cristina. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Trabalho apresentado em 57th Annual Meeting of the European Association for the Study of Diabetes 2021 - EASD2021, 2021.
    Publicado
  3. Cardoso, Susana; Diano, Sabrina; Moreira, PI. "UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults.". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Publicado
  4. T Fernandes; R Resende; MR Domingues; Moreira, PI; C Pereira. "Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Publicado
  5. D Mena; IN Alves; DF Silva; E Candeias; CR Oliveira,; R Seiça; PF Monteiro; Moreira, PI; AI Duarte. "The Neuroprotection by GLP-1 Receptor Agonists in High Cardiovascular risk and Neurodegenerative Diseases". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Publicado
  6. S Correia; M Alves; P Oliveira; G Casadesus; G Perry; Moreira, PI. "Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: A" breath of fresh air" towards effective treatment?". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Publicado
  7. Moreira, PI; C Carvalho. "WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Publicado
  8. C Carvalho; C Martin; Moreira, PI. "N epsilon-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Publicado
  9. D Franco da Silva; MI Alves; D Mena; D Vaz; PF Monteiro; Moreira, PI; AI Duarte. "The neuroprotective effects of peripheral treatment with Evolocumab in middle-aged rat at high cardiovascular risk". Trabalho apresentado em European Society for Clinical Investigation (ESCI) 2020: Utrecht, NL, Utrecht, 2020.
    Publicado
  10. D Mena; MI Alves; DF Silva; D Vaz; E Candeias; CR Oliveira; PF Monteiro; Moreira, PI; AI Duarte. "Diet-induced high cardiovascular risk compromises brain hippocampal metabolism and long-term spatial memory in middle-aged male rats". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Publicado
  11. D Mena; MI Alves; M Sjogren; DF Silva; CR Oliveira; Moreira, PI; M Bjorkqvist; AI Duarte. "Co-administration of liraglutide and ghrelin ameliorates brain mitochondrial energy metabolism in the R6/2 mouse model for Huntington's disease". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Publicado
  12. MI Alves; D Mena; DF Silva; R Seica; CR Oliveira; AI Duarte; Moreira, PI. "Type 2 diabetes mitigates brain cortical energy metabolism in middle-aged female rats". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Publicado
Tese / Dissertação
  1. Moreira, PI. "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties". Doutoramento, Universidade de Coimbra Faculdade de Medicina, 2007. http://hdl.handle.net/10316/7501.
  2. Moreira, PI. "Effect of the amyloid beta peptide on the permeability transition pore: a comparative study". Mestrado, Universidade de Coimbra - Faculdade de Ciências e Tecnologia, 2002.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/03/17 O inibidor da WWOX Zfra1-31 melhora a função cognitiva e a disfunção das mitocôndrias de cérebros de ratinhos com diabetes tipo 2 19th Meeting of Portuguese Society for Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2023/01/25 WWOX: a new therapeutic target in Type 2 diabetes-associated neurodegeneration DCV - Talks
Universidade de Coimbra, Faculdade de Ciências e Tecnologia (Coimbra, Portugal)
2022/11/12 WWOX inhibition by Zfra1-31 ameliorates brain mitochondrial dysfunction and oxidative stress in a mouse model of type 2 diabetes 2nd International Meeting of the Portuguese Society of Physiology
Sociedade Portuguesa de Fisiologia (Coimbra, Portugal)
2022/07/18 Metabolic Defects in Alzheimer's Disease International Research Conference on Neurodegenerative Diseases
Global Association for the Study of Neurodegenerative Diseases (Omaha, Estados Unidos)
2022/06/08 Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study 56th Annual Scientific Meeting European Society for Clinical Investigation
European Society for Clinical Investigation (Bari, Itália)
2022/05/25 Diabetes and Alzheimer's disease crosstalk Nova Medical School Seminars
Faculdade de Ciências Médicas, Universidade Nova de Lisboa (Lisboa, Portugal)
2022/04/22 Impaired insulin and IGF-1 signaling affects brain mitochondria and redox homeostasis Spanish Symposium on IGFs and Insulin 2022: Implications in Physiology and Disease
(Logroño, Espanha)
2022/03/10 A inibição da proteína WWOX protege a mitocôndria e previne a morte de neurónios expostos a níveis elevados de glicose 18th Meeting of Portuguese Society for Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2021/11/18 Structural and functional alterations in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease 2º Retiro do Grupo de Metabolismo, Envelhecimento e Doença (MAD) do Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
(Coimbra, Portugal)
2021/09/11 N-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells 55th Annual Scientific Meeting - ESCI Virtual 2021
European Society for Clinical Investigation
2021/07/27 Neuroprotective effect of Zfra 1-31 peptide against high glucose-induced mitochondrial dynamics and autophagy alterations 57th EASD Annual Meeting European Society for the study of diabetes 2021
European Association for the Study of Diabetes
2021/07/19 Zfra 1-31 prevents high glucose-induced neuronal death through improvement of mitochondrial and autophagy defects International Conference on Diabetes and Endocrinology. Coalesce Research Group
(Online)
2021/07/02 Alzheimer disease beyond amyloid: a preclinical perspective 35ª REUNIÃO ANUAL DO GEECD - Inovação em Doença de Alzheimer
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Coimbra, Portugal)
2021/06/10 Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: a "breath of fresh air" 55th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Online)
2021/06/09 Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model 55ª Reunião científica anual da Sociedade Europeia para a Investigação Clínica (ESCI)
European Society for Clinical Investigation (Webinar)
2021/06/06 UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021
European Society for Clinical Investigation (On line)
2021/06/06 WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death 55th Annual Scientific Meeting - ESCI Virtual 2021
European Society for Clinical Investigation
2021/06/03 Loss of HUMMR as a potential 'roadblock' for mitochondrial movement in Alzheimer's disease 35th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar)
2021/04/26 Mitochondrial dysfunction and oxidative stress in Alzheimer's disease Redox Webinar Series - Crosstalk between oxidative stress and metabolic defects: implications for Alzheimer's disease
Faculty of Pharmacy and Medicine, Sapienza University of Rome (Rome, Itália)
2020/09/26 Hypoxic precoditioning averts sporadic Alzheimer's disease-like phenotype in rats: the role of mitochondrial remodeling 34th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Portugal)
2020/09/26 Structural and functional alterations in endoplasmic reticulum-mitochondria contacts in Alzheimer's disease in vitro models 34ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar, Portugal)
2020/02/06 Changes in the Protein Composition of Mitochondrial-Associated Membranes (MAMs) in Alzheimer's Disease 50ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/05 Hypoxic preconditioning: a strategy to fight Alzheimer’s disease?
European Society of Clinical Investigation (Coimbra, Portugal)
2018/03 Mitochondrial dysfunction and energy failure in Alzheimer’s disease Focused Symposium “Bioenergetics and neurodegenerative disorders: moving from pathogenesis to therapeutics”; Advances in Neuroscience for Medical Advance
Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier (França)
2016/06/04 Alzheimer's disease: mechanistic insights and biomarkers discovery 30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2016 Alzheimer's disease: focus on mitochondria Seminars_IBILI
(Coimbra, Portugal)
2015/10 The efficacy of the antidiabetic drug liraglutide in Alzheimer’s disease-like pathology 6th Annual Alliance for Healthy Ageing: Interventions to Slow Down Aging
(Newcastle, Reino Unido)
2015/03 Insulin signaling as a bridge between diabetes and Alzheimer’s disease Gordon Research Conference - IGF & Insulin System in Physiology & Disease
(California, Estados Unidos)
2014/07 Mitochondria take center stage in Alzheimer’s disease 18th European BioEnergetics Conference – EBEC 2104
(Lisboa, Portugal)
2014/04 Etiologia e fisiopatologia das doenças neurodegenerativas Ciclo de Palestras em Atividade Física e Saúde “Exercício, Saúde e Sociedade
CIAFEL - Universidade do Porto (Porto, Portugal)
2014 A diabetes tipo 2 e a doença de Alzheimer Jornadas de Análises Clínicas e Saúde Pública – Reunião Anual 2014
Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2013 Mitochondrial crossroad in Alzheimer’s disease 47th Annual Scientific Meeting of the European Society for Clinical Investigation
(Albufeira, Portugal)
2011 Mitochondria and the Vasculature 7th International Congress on Vascular Dementia
(Riga, Letónia)
2010/11/22 Alzheimer’s disease: research tools and therapeutic perspectives Palestras do Núcleo de Estudantes de Bioquímica
Núcleo de Estudantes de Bioquímica (Coimbra, Portugal)
2010/05/03 Mitochondria, diabetes and Alzheimer’s disease Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration
Universidade do Porto (Porto, Portugal)
2009/07 A disfunção mitocondrial na doença de Alzheimer II Jornadas de Bioquímica da UTAD
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2008/07 A mitocôndria, um catalizador do envelhecimento cerebral e da demência Ciência 2008 – Encontro com a Ciência em Portugal Promovido pelos Laboratórios Associados
Fundação Calouste Gulbenkian (Lisboa, Portugal)
2007/11/08 Diabetes is a risk factor for Alzheimer disease: the role of mitochondria 5th International Congress on Vascular Dementia
(Budapeste, Hungria)
2007/11 O papel da mitocôndria na doença de Alzheimer 1º Congresso Científico de Saúde: Doenças Neurodegenerativas
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2007/04/28 Liver mitochondria isolated from ovariectomized and tamoxifen-treated ovariectomized rat females are affected by estradiol 1st Iberic Meeting on Medicinal Chemistry: Anticancer Agents – 1IMMC
(Régua, Portugal)
2006/12/08 Tamoxifen and estradiol: a deadly combination for cancer cells XV National Congress of Biochemistry
Sociedade Portuguesa de Bioquímica (Aveiro, Portugal)
2006/07 Mitochondrial autophagocytosis in Alzheimer disease 10th International Conference on Alzheimer´s Disease and Related Disorders
(Madrid, Espanha)
2006/03 Tamoxifen and estradiol lead to mitochondrial complex I failure International Courses on Toxicology “Smart Toxicology: Subcellular Targets of Anti-Cancer Therapy”
Universidade de Coimbra, Centro de Neurociencias e Biologia Celular
2006 Oxidative Stress in Alzheimer disease: role of antioxidants 4th International Congress on the Improvement of the Quality of Life in Dementia, Epilepsy, MS and Peripheral Neuropathies
(Odessa, Ucrânia)
2005/10 Brain mitochondria as a link between Alzheimer’s disease and diabetes 4th International Congress on Vascular Dementia
(Porto, Portugal)
2005/07/03 Brain mitochondrial dysfunction is a common feature in both diabetes and Alzheimer’s disease 19ª Reunião do grupo de estudos do envelhecimento cerebral e demência
(Tomar, Portugal)
2005/04 Effect of amyloid beta-peptide on brain mitochondria isolated from diabetic rats Mitochondria: Between Life and Death – International Courses on Toxicology
(Coimbra, Portugal)
2003/12/15 Diabetes and Alzheimer’s Disease: Are Brain Mitochondria a Link Between Both Pathologies? 1º Workshop de Bioquímica Clínica
(Porto, Portugal)
2003/12 Role of Insulin in Brain Mitochondria Status of Type 1 Diabetic Rats. Does Amyloid beta-Peptide Interferes with Mitochondrial Function? 16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine
2002/07/14 Bioenergética mitocondrial e o envelhecimento 16ª Reunião-Grupo de Estudos – Envelhecimento Cerebral e Demência
2001 Mitochondria: a target for beta-amyloid peptide XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica
(Coimbra, Portugal)
2000/07/02 Mitocôndria e o envelhecimento: efeito do peptídeo Abeta25-35 14ª Reunião - Grupo de Estudos: Envelhecimento Cerebral e Demência

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/04/03 - 2023/04/13 ONE HEALTH: A Metabolic Approach from the Cell to Society Advanced Course - PHD Programme in Experimental Biology and Biomedicine (2023)
Outro (Coorganizador)
 Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal
2022/04/04 - 2022/04/08 Advanced Course "Metabolic and inflammatory drivers in age-related neurodegenerative diseases" (2022/04/04)
Outro (Coorganizador)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/23 - 2019/05/24 Symposium - Neurobiology of Aging; 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019 - 2019)
Simpósio
 European Society for Clinical Investigation, Países Baixos
2019/04/08 - 2019/04/12 Advanced Course - Neurodegenerative Disorders PhD Programme in Experimental Biology and Biomedicine (2019 - 2019)
Outro (Coorganizador)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/02/25 - 2013/03/01 Advanced Course - Neurobiology and Disease Doctoral Programme in Health Sciences (2013 - 2013)
Outro (Coorganizador)
 Universidade de Coimbra - Faculdade de Medicina, Portugal
2012/12/10 - 2012/12/14 Advanced Course - Biology of Proteolysis in Pathology; PhD Programme in Experimental Biology and Biomedicine (2012 - 2012)
Outro (Coorganizador)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/07/18 - 2022/07/18 Session chair - International Research Conference on Neurodegenerative Diseases
Conferência
 International Research Conference on Neurodegenerative Diseases

Arbitragem científica em conferência

Nome da conferência Local da conferência
2022/07/01 - 2022/07/02 36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/05 - Atual Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2018 - Atual Journal of Alzheimer's Disease Reports IOS Press
2018 - Atual Diabetologia (1432-0428) Springer-Verlag
2018 - Atual Brain Behavior and Immunity (1090-2139) Elsevier
2018 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2018 - Atual Cellular and Molecular Life Sciences (1420-9071) Springer-Verlag
2018 - Atual EClinicalMedicine (2589-5370) Elsevier
2018 - Atual Nature Reviews Neurology (1759-4766) Springer Science and Business Media LLC
2018 - Atual Neurotherapeutics (1878-7479) Springer-Verlag
2017 - Atual Progress in Neurobiology (0301-0082) Elsevier
2017 - Atual Alzheimers Disease & Dementia (2578-6490) sPage.direcT
2017 - Atual American Journal of Alzheimer s Disease (1082-5207) SAGE Publications
2017 - Atual Molecular Biology Reports (1573-4978) Springer-Verlag
2016 - Atual Rejuvenation Research (1557-8577) Mary Ann Liebert
2016 - Atual Diabetes Obesity and Metabolism (1463-1326) Wiley (Blackwell Publishing)
2016 - Atual Nature Reviews Endocrinology (1759-5037) Springer Science and Business Media LLC
2016 - Atual The Lancet Diabetes & Endocrinology (2213-8587) Elsevier
2015 - Atual PeerJ (2167-8359) PeerJ
2015 - Atual BioMed Research International (2314-6141) Hindawi Limited
2015 - Atual Current Alzheimer Research (1567-2050) Bentham Science
2015 - Atual Journal of Clinical Investigation (1558-8238) American Society for Clinical Investigation
2015 - Atual Medicinal Research Reviews (1098-1128) Wiley (John Wiley & Sons)
2015 - Atual Neuropathology and Applied Neurobiology (1365-2990) Wiley (Blackwell Publishing)
2015 - Atual Expert Opinion on Drug Discovery (1746-045X) Informa UK (Taylor & Francis)
2015 - Atual Molecular Neurobiology (0893-7648) Springer-Verlag
2015 - Atual Trends in Neurosciences (0166-2236) Elsevier
2014 - Atual Therapeutic Advances in Chronic Disease (2040-6231) SAGE Publications
2014 - Atual Neuropharmacology (0028-3908) Elsevier
2014 - Atual Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2014 - Atual Trends in Biotechnology (0167-7799) Elsevier
2013 - Atual Expert Reviews in Molecular Medicine (1462-3994) Cambridge University Press
2012 - Atual Frontiers in Aging Neuroscience (1663-4365) Frontiers Media SA
2012 - Atual Diabetes
2012 - Atual Neurobiology of Disease (1095-953X) Elsevier
2012 - Atual Neurobiology of Disease (1095-953X) Elsevier
2012 - Atual Free Radical Biology and Medicine (0891-5849) Elsevier
2012 - Atual Neuroendocrinology (1423-0194) S. Karger AG
2012 - Atual Biochemical Pharmacology (0006-2952) Elsevier
2012 - Atual Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2010 - Atual Journal of Alzheimer s Disease (1875-8908) IOS Press
2010 - Atual Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2010 - Atual European Journal of Pharmacology (0014-2999) Elsevier
2009 - Atual Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2009 - Atual European Journal of Clinical Investigation (1365-2362) Wiley (Blackwell Publishing)
2009 - Atual Neurosciences (1658-3183) Neurosciences
2008 - Atual The FASEB Journal (1530-6860) Federation of American Society for Experimental Biology
2005 - Atual Experimental Neurology (1090-2430) Elsevier
2004 - Atual Expert Review of Neurotherapeutics (1744-8360) Informa UK (Taylor & Francis)
2013 - 2019 British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2016 - Atual Evaluator for European Science Foundation
Avaliador
 European Science Foundation, França
2021 - 2021 Evaluator of the reports submitted by Doctorate Researchers (Decreto-Lei n.º 57/2016)
Avaliador
 Faculty of Medicine, University of Coimbra, Portugal
2016 - 2021 Evaluator of the Marie Sklodowska-Curie Individual Fellowships (Life Sciences Panel)
Avaliador
 European Commission, Bélgica European Commission
2016 - 2021 Evaluator of applications - Alzheimer's Association Research Grant Program
Avaliador
 Alzheimer's Association, Estados Unidos Alzheimer's Association
2019/12 - 2020/12 Committee Member on Novo Nordisk Foundation Challenge Programme 2020 - Biomedicine and Health Sciences
Avaliador
 Novo Nordisk Fonden, Dinamarca Novo Nordisk Fonden
2018 - 2018 Evaluator of applications within the call "What causes Brain Disease?"
Avaliador
 Lundbeckfonden, Dinamarca Lundbeckfonden
2016 - 2018 Evaluator of applications submitted to ANR Agence nationale de la recherche, França Agence nationale de la recherche
2014 - 2015 Evaluator Post-Doctoral Fellowships (Experimental Biology and Biochemistry Panel)
Avaliador
 Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal), Portugal Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/05 - Atual Fisiologia II (Master Universitario) Universidade de Cabo Verde, Cabo Verde
2012 - Atual Fundamentos de Fisiologia II Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/02 - Atual Fisiologia Humana Geral Mestrado Integrado em Medicina Dentária (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2011 - Atual Fundamentos de Fisiologia I Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Atual Fundamentos de Fisiologia II Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Atual Fundamentos de Fisiologia I Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006/02 - Atual Fisiologia II (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2005/12/01 - Atual Fisiologia I Mestrado Integrado em Medicina (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2023/04/03 - 2023/04/13 PHD Programme in Experimental Biology and Biomedicine - PDBEB ONE HEALTH: A Metabolic Approach from the Cell to Society (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal

Membro de associação

Nome da associação Tipo de participação
2022 - Atual Portuguese Physiological Society Member
2007 - Atual Portuguese Society of Diabetology Membro
2007 - Atual European Association for the Study of Diabetes Membro
2006 - Atual Portuguese Society for Neuroscience Membro

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2022/07/18 - 2022/07/19 IRCND 2022 Long Range Planning Committee
Membro
2019/05/22 - 2019/05/24 Scientific committee - 53rd Annual Meeting of the European Society for Clinical Investigation (ESCI)
Membro
 European Society for Clinical Investigation, Países Baixos
2018/07/13 - 2018/07/13 Scientific Committee - International Symposium; MitoPorto – Mitochondrial evolution, metabolism and disease
Outro
2013/05/30 - 2013/06/01 Organizing committee - XIII Reunião da Sociedade Portuguesa de Neurociências
Membro
Distinções

Prémio

2023 Rosalind Franklin Society Special Award in Science 2022
Rosalind Franklin Society , Estados Unidos

Mary Ann Liebert Inc., Estados Unidos
2023 Honorable Mention Pedro Eurico Lisboa / SPD
Sociedade Portuguesa de Diabetologia, Portugal
2017 Orlando Leitão Prize
Sociedade Portuguesa de Neurologia, Portugal
2015 Mantero Belard Prize
Santa Casa da Misericórdia de Lisboa, Portugal
2014 2nd prize for research project
Sociedade Portuguesa de Diabetologia, Portugal
2013 Best Research Paper - Basic Science
Universidade de Coimbra - Faculdade de Medicina, Portugal
2010 ASN Neuro Poster Prize
American Society of Neurochemistry, Estados Unidos
2008 L'Oreal for Women in Science award
L’Oreal Portugal , Portugal

Comissão Nacional da UNESCO , Portugal

Fundação para a Ciência e a Tecnologia, Portugal
2003 Stimulus to Research Prize
Fundação Calouste Gulbenkian, Portugal
2003 Best Poster Prize
Physiological Society, Reino Unido

Título

2022 Member of Global Association for the Study of Neurodegenerative Diseases
2021 Member of the Selection Committee Top 25 Outstanding Women Listeners 2021
2021 Member of Neurodegeneration Precision Medicine Initiative
2018 Member of the Dana Alliance for Brain Initiatives
Dana Foundation, Estados Unidos
2018 Member of European Science Foundation (ESF) College of Expert Reviewers
European Science Foundation, França

Outra distinção

2023 Research.com_ranked #4 in Portugal among Best Scientists in Biology and Biochemistry
2023 Research.com_ranked #9 in Portugal among Best Scientists in Medicine
2022 World's Top 2% Scientists 2022
2021 Expertscape World Expert in Mitochondria
2021 World's Top 2% Scientists 2021