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Paula I. Moreira received her PhD in Biomedical Sciences from University of Coimbra, Portugal, in 2007. Currently, she is Assistant Professor at the Faculty of Medicine and Principal Investigator at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. Moreira's group is interested in elucidating the role of energy metabolism, with an emphasis on mitochondria (energy, homeostasis and signals) and metabolic hormones-mediated signaling pathways in brain changes occurring in metabolic disorders (e.g. diabetes and obesity) and neurodegenerative diseases, particularly Alzheimer disease. We are also interested in clarifying the role of hypoxia and sex/gender in the neurodegenerative events that characterize these pathologies. Additionally, we are exploring the therapeutic potential of anti-diabetic drugs, metabolic hormones and mitochondrial modulators. To achieve our goals we use several experimental models such as isolated mitochondria, in vitro and in vivo models of disease and human samples. Moreira has published more than 200 scientific peer-reviewed articles. She is deputy editor of Journal of Alzheimer's Disease, associate editor of Journal of Alzheimer's Disease Reports and Frontiers of Aging Neuroscience, section editor of BBA-Molecular Basis of Disease and belongs to the editorial board of Antioxidants and Redox Signaling and Aging Brain. Paula Moreira won the Stimulus to Research prize, in 2003, supported by the Calouste Gulbenkian Foundation and, in 2008, the L¿Oréal for Women in Science Award supported by L'Oreal Portugal/UNESCO/ FCT.
Identificação

Identificação pessoal

Nome completo
Paula Isabel da Silva Moreira

Nomes de citação

  • Moreira, Paula
  • Paula I. Moreira
  • Moreira, PI
  • Moreira, Paula Isabel

Identificadores de autor

Ciência ID
9C16-2F47-6D91
ORCID iD
0000-0001-5177-6747
Google Scholar ID
https://scholar.google.pt/citations?user=5JO6pzkAAAAJ&hl=pt-PT
Researcher Id
B-3608-2009
Scopus Author Id
56038291200

Endereços de correio eletrónico

  • pismoreira@gmail.com (Profissional)
  • pimoreira@fmed.uc.pt (Profissional)
  • venta@ci.uc.pt (Profissional)

Moradas

  • Pólo III, Pólo das Ciências da Saúde, 3000-548, Azinhaga de Santa Comba, Celas, Coimbra, Portugal (Profissional)
  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1142&idgrp=1188&IdGrupo=1138&IdSeccao=&hash=39 (Profissional)
  • https://www.researchgate.net/profile/Paula_Moreira3 (Profissional)
  • https://publons.com/researcher/999744/paula-i-moreira/ (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2007/07/16
Concluído
Ciências Biomédicas (Doutoramento)
Especialização em Neurociências
Universidade de Coimbra - Faculdade de Medicina, Portugal
"Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties" (TESE/DISSERTAÇÃO)
Aprovado com Distinção e Louvor, por unanimidade
2002/05/23
Concluído
Biologia Celular (Mestrado)
Especialização em Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effect of Aß25-35 in the mitochondrial permeability transition pore: a comparative study " (TESE/DISSERTAÇÃO)
1998/07/09
Concluído
Biologia (Licenciatura)
Especialização em Ramo Científico
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Percurso profissional

Ciência

2007 - Atual Investigador (Investigação)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

2016 - Atual Professor Auxiliar (Docente Universitário)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015 Professor Auxiliar Convidado (Docente Universitário)
University of Texas at San Antonio, Estados Unidos
2011 - 2015 Professor Auxiliar Convidado (Docente Universitário)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2005 - 2011 Assistente (Docente Universitário)
Universidade de Coimbra - Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2020 - Atual Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism
SFRH/BD/148801/2019
Orientador
Universidade de Coimbra - Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2019 - Atual Rational Drug Design of novel potent multifunctional agents for Alzheimer’s Disease treatment
SFRH/BD/138460/2018
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2019/03/31 Exploring the crosstalk of neuronal WWOX and mitochondria in type 2 diabetes-associated neurodegeneration
SFRH/BPD/107741/2015
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2019/01/31 Unveiling the potential of HIF-1a as a biomarker and therapeutic target in Alzheimer’s disease
SFRH/BPD/109822/2015
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2017 - 2019 Unravelling the neuroprotective role of peripheral co-administration of liraglutide and ghrelin on brain and cognitive function in Huntington disease
SFRH/BPD/84473/2012
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2018 Does habitual physical activity mitigates chemotherapy-induced cardiac and brain dysfunction in a mouse model of prostate cancer? Role of mitochondrial-mediated mechanisms
SFRH/BPD/108322/2015
Orientador
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal
2015 - 2018 HDAC3 neurophysiology and drug targeting in neurodegeneration
SFRH/BPD/102259/2014
Orientador
Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2014 - 2017 Mild mitochondrial uncoupling: exploring its protective effects against brain damage associated to insulin-induced hypoglycemic events in type 1 diabetes
SFRH/BPD/95770/2013
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2016/06/30 Mitochondrial trafficking in Alzheimer’s disease and hypoxic preconditioning: unveiling the role of the hypoxia up-regulated mitochondrial movement regulator
SFRH/BPD/84163/2012
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2013 - 2016 IMPACT OF PERIPHERAL EXENDIN-4 THERAPY ON THE MOLECULAR MECHANISMS UNDERLYING DIFFERENTIAL GENDER-RELATED BRAIN FUNCTION IN LONG-TERM TYPE 2 DIABETES
SFRH/BPD/84473/2012
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2009 - 2013/02 Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria
SFRH/BD/43965/2008
Orientador
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2009 - 2012/12/31 DECIPHERING THE ROLE OF MITOCHONDRIA AND UNCOUPLING PROTEINS IN HYPOGLYCEMIA- AND/OR HYPERGLYCEMIA-INDUCED BRAIN INJURY
SFRH/BD/43968/2008
Orientador
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2008 - 2012/02/29 ROLE OF MITOCHONDRIA IN THE REGULATION OF THE TRANSCRIPTION FACTOR HYPOXIA-INDUCIBLE FACTOR-1 IN BRAIN ENDOTHELIUM: POTENTIAL PROTECTION AGAINST DIABETIC COMPLICATIONS
SFRH/BD/40702/2007
Orientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2010 Impact of aging and gender in diabetic brain metabolism, oxidative stress and inflammation: Is there a (protective) role for insulin therapy?
SFRH/BPD/26872/2006
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2002 - 2006 Mitocôndria e sua relação com o envelhecimento, a doença de Alzheimer e a diabetes: papel da proteína b-amilóide
SFRH/BD/5320/2001
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
2000 - 2002 Efeito do peptídeo beta-amilóide no poro de permeabilidade transitória da mitocôndria
PRAXIS XXI/BM/20952/1999
Bolseiro de Mestrado
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Projeto

Designação Financiadores
2020 - 2026/12/31 Multidisciplinary Institute of Ageing (MIA) - Portugal
info:eu-repo/grantAgreement/EC/H2020/857524/EU
Investigador
European Commission
2019 - 2021/07 A Saúde no Saber
45-2019/478
Investigador
Ciência Viva, Portugal
2018 - 2021 The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology
CENTRO-01-0145-FEDER-028214
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2020 HealthyAging2020
HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323
Investigador
Comissão de Coordenação e Desenvolvimento Regional do Centro
2016 - 2019/12/31 Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos
SII&DT 3269 Drugs2CAD
Investigador
Universidade de Coimbra, Portugal
Agência Nacional de Inovação, S.A.
2018 - 2019 Brain protection by Evolocumab in individuals at high risk for cardiovascular disease: from bench to bedside
PEPITA2018
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra - Faculdade de Medicina
2016 - 2018 Targeting huntingtin proteostasis and mitochondria to prevent neuronal dysfunction in Huntington's disease
PTDC/NEU-NMC/0412/2014
Investigador
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2018 The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression?
Prémio Mantero Belard 2015
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 - 2015/02 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
Provided by PTCRIS: 135805
135805
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2014 - 2015 Selenate and Reduction of Neurofibrillary Tangle Formation: Role of Selenoproteins
U54MD008149
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
National Institute on Minority Health and Health Disparities
2013 - 2015 Mitochondrial Trafficking In Alzheimer Disease: Revealing the Role of HUMMR
NIRG-13-282387
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Alzheimer's Association
2013 - 2015 New Strategies to Manage Brain Diseases
CENTRO-07-ST24-FEDER-002002
Investigador
Programa Operacional Regional do Centro - Projecto Mais Centro
2013 - 2014 Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role?
MOREIRA06JAN13
Investigador responsável
Faculty of Medicine, University of Coimbra
2010 - 2013/09 Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem.
108326
Provided by PTCRIS: 108326
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2013/08 Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease
110990
Provided by PTCRIS: 110990
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2013/03 The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins
103325
Provided by PTCRIS: 103325
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2012/03 A new route for endothelial dysfunction on diabetes: From phenotypes to molecules
67498
Provided by PTCRIS: 67498
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2012 Influence of gender on the molecular mechanisms underlying aging-related changes in diabetic brain: the impact of insulin therapy
PMADSC
Investigador responsável
Faculty of Medicine, University of Coimbra
2008 - 2010 Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs
III-45
Investigador responsável
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Institute for Interdisciplinary Research, University of Coimbra
2008 - 2009 Da diabetes à demência: Explorando as vias de sinalização mediadas pela mitocôndria e suas proteínas desacopladoras
----
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2009 Exploring the crosstalk between mitochondrial reactive oxygen species and the transcriptional factor hypoxia factor-1 in brain and retinal endothelium
------
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Foundation for the Study of Diabetes
Produções

Publicações

Artigo em revista
  1. Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease". Aging (2021): http://dx.doi.org/10.18632/aging.202916.
    10.18632/aging.202916
  2. Carvalho, Cristina; Moreira, Paula I.. "WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration". Metabolism 116 (2021): 154616. http://dx.doi.org/10.1016/j.metabol.2020.154616.
    10.1016/j.metabol.2020.154616
  3. Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Correia, Sónia Catarina; Carvalho, Cristina; Campos, Elisa Julião; Baptista, Filipa Isabel; Moreira, Paula Isabel; Ambrósio, António Francisco. "Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer's Disease". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-021-02316-x.
    10.1007/s12035-021-02316-x
  4. Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira. "IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis". Biomedicines 9 2 (2021): 158-158. https://doi.org/10.3390/biomedicines9020158.
    10.3390/biomedicines9020158
  5. Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira. "Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease". International Journal of Molecular Sciences 22 1 (2021): 461-461. https://doi.org/10.3390/ijms22010461.
    10.3390/ijms22010461
  6. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  7. Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique. "PINK1/PARKIN signalling in neurodegeneration and neuroinflammation". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-01062-w.
    Publicado • 10.1186/s40478-020-01062-w
  8. Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al. "Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort". International Journal of Environmental Research and Public Health (2020): https://doi.org/10.3390/ijerph17176051.
    10.3390/ijerph17176051
  9. Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al. "Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing". Nature Reviews Drug Discovery (2020): http://dx.doi.org/10.1038/s41573-020-0072-x.
    10.1038/s41573-020-0072-x
  10. Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al. "Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 6 (2020): 165752. http://dx.doi.org/10.1016/j.bbadis.2020.165752.
    10.1016/j.bbadis.2020.165752
  11. Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui. "Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer's disease". Health and Technology (2020): http://dx.doi.org/10.1007/s12553-020-00413-w.
    10.1007/s12553-020-00413-w
  12. Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.
    10.3390/biom10040535
  13. Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al. "Liraglutide Protects Against Brain Amyloid-ß1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21051746.
    10.3390/ijms21051746
  14. Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A.. "The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice". Free Radical Biology and Medicine 146 (2020): 372-382. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021.
    10.1016/j.freeradbiomed.2019.11.021
  15. Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR. "An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease". Future Medicinal Chemistry 11 24 (2019): 3179-3194. http://dx.doi.org/10.4155/fmc-2019-0163.
    10.4155/fmc-2019-0163
  16. Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa. "Is Alzheimer's disease an inflammasomopathy?". Ageing Research Reviews 56 (2019): 100966. http://dx.doi.org/10.1016/j.arr.2019.100966.
    10.1016/j.arr.2019.100966
  17. Bernardes, Rui; Ferreira, Hugo; Martins, João; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro. "Retinal thickness of the triple-transgenic mice model of Alzheimer’s disease at the age of one month". Acta Ophthalmologica 97 S263 (2019): http://dx.doi.org/10.1111/j.1755-3768.2019.5467.
    10.1111/j.1755-3768.2019.5467
  18. Cabral Pinto, Marina M. S.; Marinho-Reis, Paula; Almeida, Agostinho; Pinto, Edgar; Neves, Orquídia; Inácio, Manuela; Gerardo, Bianca; et al. "Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area". International Journal of Environmental Research and Public Health 16 22 (2019): 4560. http://dx.doi.org/10.3390/ijerph16224560.
    10.3390/ijerph16224560
  19. Chiquita, Samuel; Campos, Elisa J.; Castelhano, João; Ribeiro, Mário; Sereno, José; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco. "Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study". Alzheimer's Research & Therapy 11 1 (2019): http://dx.doi.org/10.1186/s13195-019-0542-8.
    10.1186/s13195-019-0542-8
  20. Correia, Sónia C.; Carvalho, Cristina; Cardoso, Susana; Moreira, Paula I.. "Post-translational modifications in brain health and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865 8 (2019): 1947-1948. http://dx.doi.org/10.1016/j.bbadis.2019.05.006.
    10.1016/j.bbadis.2019.05.006
  21. Pinho, Tiffany S.; Correia, Sónia C.; Perry, George; Ambrósio, António Francisco; Moreira, Paula I.. "Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865 8 (2019): 2048-2059. http://dx.doi.org/10.1016/j.bbadis.2018.10.037.
    10.1016/j.bbadis.2018.10.037
  22. Susana Cardoso; Paula I. Moreira. "Diabesity and brain disturbances: A metabolic perspective". Molecular Aspects of Medicine 66 (2019): 71-79. https://doi.org/10.1016/j.mam.2018.10.002.
    10.1016/j.mam.2018.10.002
  23. Chiquita, Samuel; Ribeiro, Mário; Castelhano, João; Oliveira, Francisco; Sereno, José; Batista, Marta; Abrunhosa, Antero; et al. "A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss". Human Molecular Genetics 28 13 (2019): 2174-2188. http://dx.doi.org/10.1093/hmg/ddz045.
    10.1093/hmg/ddz045
  24. Chiquita, Samuel; Rodrigues-Neves, Ana C.; Baptista, Filipa I.; Carecho, Rafael; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.. "The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel". Molecular Neurobiology 56 8 (2019): 5416-5435. http://dx.doi.org/10.1007/s12035-018-1461-6.
    10.1007/s12035-018-1461-6
  25. Moreira, PI. "Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease.". Advances in experimental medicine and biology (2019): https://doi.org/10.1007/978-981-13-3540-2_9.
    10.1007/978-981-13-3540-2_9
  26. Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Baptista, Filipa; Moreira, Paula; Ambrósio, António. "Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer's disease?". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00020.
    10.3389/conf.fncel.2019.01.00020
  27. Ana I. Duarte; Marie Sjögren; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira; Maria Björkqvist. "Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington’s Disease". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-27121-w.
    10.1038/s41598-018-27121-w
  28. Tiffany S. Pinho; Diogo M. Verde; Sónia C. Correia; Susana M. Cardoso; Paula I. Moreira. "O-GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease". Ageing Research Reviews 46 (2018): 32-41. https://doi.org/10.1016/j.arr.2018.05.003.
    10.1016/j.arr.2018.05.003
  29. Cabral Pinto, Marina M. S.; Marinho-Reis, A. Paula; Almeida, Agostinho; Freitas, Sandra; Simões, Mário R.; Diniz, M. Luísa; Pinto, Edgar; et al. "Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing". Exposure and Health 11 3 (2018): 181-194. http://dx.doi.org/10.1007/s12403-018-0274-1.
    10.1007/s12403-018-0274-1
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  208. Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G.. "Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?". Drug News and Perspectives 18 1 (2005): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS.
    10.1358/dnp.2005.18.1.877165
  209. Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Staying connected: Synapses in alzheimer disease". American Journal of Pathology 165 5 (2004): 1461-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS.
  210. Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G.. "Therapeutic potential of oxidant mechanisms in Alzheimer's disease". Expert Review of Neurotherapeutics 4 6 (2004): 995-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS.
    10.1586/14737175.4.6.995
  211. Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G.. "Neurofilament proteins in neurodegenerative diseases". Cellular and Molecular Life Sciences 61 24 (2004): 3057-3075. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS.
    10.1007/s00018-004-4268-8
  212. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R.. "Effect of streptozotocin-induced diabetes on rat brain mitochondria". Journal of Neuroendocrinology 16 1 (2004): 32-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS.
    10.1111/j.1365-2826.2004.01107.x
  213. Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Hydroxytamoxifen protects against oxidative stress in brain mitochondria". Biochemical Pharmacology 68 1 (2004): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS.
    10.1016/j.bcp.2004.03.019
  214. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R.. "Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure". Diabetes 52 6 (2003): 1449-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS.
    10.2337/diabetes.52.6.1449
  215. Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS.
  216. Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C.. "Effect of amyloid ß-peptide on permeability transition pore: A comparative study". Journal of Neuroscience Research 69 2 (2002): 257-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS.
    10.1002/jnr.10282
  217. Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C.. "Amyloid ß-peptide promotes permeability transition pore in brain mitochondria". Bioscience Reports 21 6 (2001): 789-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS.
    10.1023/A:1015536808304
  218. Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R.. "Synaptosomal response to oxidative stress: Effect of vinpocetine". Free Radical Research 32 1 (2000): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS.
  219. Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS.
  220. Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS.
    10.1006/exnr.1999.7270
Capítulo de livro
  1. Moreira, PI; Sónia C. Correia. "Unraveling the Role of Mitochondria in Alzheimer’s Disease". In Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach, 407. Oxford, Estados Unidos: Oxford University Press, USA, 2020.
    Publicado
  2. Cardoso, Susana; Moreira, Paula I.. "Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones". In Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases, 37-64. Elsevier, 2020.
    Publicado • 10.1016/bs.irn.2020.02.010
  3. Carvalho, Cristina; Moreira, Paula I.. "Cognitive Impairment in Obesity and Diabetes". In Obesity and Diabetes, 399-414. Springer International Publishing, 2020.
    10.1007/978-3-030-53370-0_29
  4. Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui. "Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer’s Disease". In XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, 1816-1821. Springer International Publishing, 2019.
    10.1007/978-3-030-31635-8_220
  5. Correia, S.C.; Moreira, P.I.. "Role of mitochondria in neurodegenerative diseases: The dark side of the "Energy factory"". 2018.
  6. Cardoso, S.M.; Correia, S.C.; Carvalho, C.; Moreira, P.I.. "Mitochondria in Alzheimer’s disease and diabetes-associated neurodegeneration: License to heal!". 2017.
    10.1007/164_2017_3
  7. Cardoso, S.; Seiça, R.; Moreira, P.I.. "Diabesity and brain energy metabolism: The case of alzheimer’s disease". 2017.
    10.1007/978-3-319-63260-5_5
  8. Castellani, R.J.; Correia, S.C.; Moreira, P.I.; Perry, G.. "Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria". 2016.
    10.1016/B978-0-12-802173-6.00018-6
  9. Correia, S.C.; Moreira, P.I.; Perry, G.. "Autophagy in alzheimer’s disease: A cleaning service out-of-order?". 2015.
    10.1007/978-3-319-13939-5_7
  10. Marques-Aleixo, I.; Santos-Alves, E.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Exercise-Induced Protection Against Aging and Neurodegenerative Diseases: Role of Redox- and Mitochondrial-Based Alterations". 2015.
    10.1002/9781118840634.ch26
  11. Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Impact of green tea (Camellia Sinensis L.) consumption in diabetes mellitus-induced neurodegeneration". 2015.
  12. Castellani, R.J.; Zhu, X.; Perry, G.; Moreira, P.I.. "Alzheimer's Disease: An Overview". 2014.
    10.1016/B978-0-12-801238-3.04491-3
  13. Castellani, R.J.; Moreira, P.I.; Zhu, X.; Perry, G.. "Alzheimer's Disease: Pathology and Pathogenesis". 2014.
    10.1016/B978-0-12-801238-3.00160-4
  14. Santos, R.X.; Moreira, P.I.. "Mtor is a potential therapeutic target for alzheimer's disease". 2014.
  15. Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.C.; Moreira, P.I.. "Chronic hypoxia, type 2 diabetes and Alzheimer's disease: A dangerous triad". 2013.
  16. Duarte, A.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.I.; et al. "The Janus Face of Insulin in Brain". 2013.
    10.1002/9781118395318.ch5
  17. Cardoso, S.; Carvalho, C.; Correia, S.; Santos, R.X.; Santos, M.S.; Moreira, P.I.. "Mitochondrial uncoupling proteins - therapeutic targets in neurodegeneration?". 2011.
  18. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Diabetes, mitochondria and brain endothelium dysfunction: A dangerous triad for neurodegeneration?". 2011.
  19. Nunomura, A.; Takeda, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G.. "Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease". 2009.
    10.1007/978-0-387-87995-6_9
  20. Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Perry, G.. "The potential application of antioxidant agents in Alzheimer disease therapeutics". In Ageing research reviews. 2007.
    10.1007/978-0-387-71522-3_12
Edição de número de revista
  1. Moreira, PI; George Perry; Jesus Avila; Aaron Serensen; Massimo Tabaton. "Preface: Alzheimer's Disease: New Beginnings". Journal of Alzheimer s Disease 64 1 (2018): https://content.iospress.com/journals/journal-of-alzheimers-disease/64/s1.
    Publicado • 10.1111/nyas.1982.396.issue-1
  2. Moreira, P.I.. "Mini-Symposium: Energy Demand and Energy Supply in Alzheimer’s Disease - Introduction". Brain Pathology 26 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988637950&partnerID=MN8TOARS.
    10.1111/bpa.12398
Livro
  1. Moreira, PI. Alzheimer's Disease: New Beginnings. Países Baixos: IOS Press BV. 2018.
    Publicado
Poster em conferência
  1. Moreira, PI. "Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer's disease: a longitudinal in vivo multimodal study". Trabalho apresentado em ARVO Annual Meeting, 2019.
Tese / Dissertação
  1. Moreira, PI. "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties". Doutoramento, Universidade de Coimbra Faculdade de Medicina, 2007. http://hdl.handle.net/10316/7501.
  2. Moreira, PI. "Effect of the amyloid beta peptide on the permeability transition pore: a comparative study". Mestrado, Universidade de Coimbra - Faculdade de Ciências e Tecnologia, 2002.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/05 Hypoxic preconditioning: a strategy to fight Alzheimer’s disease?
European Society of Clinical Investigation (Coimbra, Portugal)
2018/03 Mitochondrial dysfunction and energy failure in Alzheimer’s disease Focused Symposium “Bioenergetics and neurodegenerative disorders: moving from pathogenesis to therapeutics”; Advances in Neuroscience for Medical Advance
Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier (França)
2016/06/04 Alzheimer's disease: mechanistic insights and biomarkers discovery 30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2016 Alzheimer's disease: focus on mitochondria Seminars_IBILI
(Coimbra, Portugal)
2015/10 The efficacy of the antidiabetic drug liraglutide in Alzheimer’s disease-like pathology 6th Annual Alliance for Healthy Ageing: Interventions to Slow Down Aging
(Newcastle, Reino Unido)
2015/03 Insulin signaling as a bridge between diabetes and Alzheimer’s disease Gordon Research Conference - IGF & Insulin System in Physiology & Disease
(California, Estados Unidos)
2014/07 Mitochondria take center stage in Alzheimer’s disease 18th European BioEnergetics Conference – EBEC 2104
(Lisboa, Portugal)
2014/04 Etiologia e fisiopatologia das doenças neurodegenerativas Ciclo de Palestras em Atividade Física e Saúde “Exercício, Saúde e Sociedade
CIAFEL - Universidade do Porto (Porto, Portugal)
2014 A diabetes tipo 2 e a doença de Alzheimer Jornadas de Análises Clínicas e Saúde Pública – Reunião Anual 2014
Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2013 Mitochondrial crossroad in Alzheimer’s disease 47th Annual Scientific Meeting of the European Society for Clinical Investigation
(Albufeira, Portugal)
2011 Mitochondria and the Vasculature 7th International Congress on Vascular Dementia
(Riga, Letónia)
2010/11/22 Alzheimer’s disease: research tools and therapeutic perspectives Palestras do Núcleo de Estudantes de Bioquímica
Núcleo de Estudantes de Bioquímica (Coimbra, Portugal)
2010/05/03 Mitochondria, diabetes and Alzheimer’s disease Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration
Universidade do Porto (Porto, Portugal)
2009/07 A disfunção mitocondrial na doença de Alzheimer II Jornadas de Bioquímica da UTAD
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2008/07 A mitocôndria, um catalizador do envelhecimento cerebral e da demência Ciência 2008 – Encontro com a Ciência em Portugal Promovido pelos Laboratórios Associados
Fundação Calouste Gulbenkian (Lisboa, Portugal)
2007/11/08 Diabetes is a risk factor for Alzheimer disease: the role of mitochondria 5th International Congress on Vascular Dementia
(Budapeste, Hungria)
2007/11 O papel da mitocôndria na doença de Alzheimer 1º Congresso Científico de Saúde: Doenças Neurodegenerativas
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2007/04/28 Liver mitochondria isolated from ovariectomized and tamoxifen-treated ovariectomized rat females are affected by estradiol 1st Iberic Meeting on Medicinal Chemistry: Anticancer Agents – 1IMMC
(Régua, Portugal)
2006/12/08 Tamoxifen and estradiol: a deadly combination for cancer cells XV National Congress of Biochemistry
Sociedade Portuguesa de Bioquímica (Aveiro, Portugal)
2006/07 Mitochondrial autophagocytosis in Alzheimer disease 10th International Conference on Alzheimer´s Disease and Related Disorders
(Madrid, Espanha)
2006/03 Tamoxifen and estradiol lead to mitochondrial complex I failure International Courses on Toxicology “Smart Toxicology: Subcellular Targets of Anti-Cancer Therapy”
Universidade de Coimbra, Centro de Neurociencias e Biologia Celular
2006 Oxidative Stress in Alzheimer disease: role of antioxidants 4th International Congress on the Improvement of the Quality of Life in Dementia, Epilepsy, MS and Peripheral Neuropathies
(Odessa, Ucrânia)
2005/10 Brain mitochondria as a link between Alzheimer’s disease and diabetes 4th International Congress on Vascular Dementia
(Porto, Portugal)
2005/07/03 Brain mitochondrial dysfunction is a common feature in both diabetes and Alzheimer’s disease 19ª Reunião do grupo de estudos do envelhecimento cerebral e demência
(Tomar, Portugal)
2005/04 Effect of amyloid beta-peptide on brain mitochondria isolated from diabetic rats Mitochondria: Between Life and Death – International Courses on Toxicology
(Coimbra, Portugal)
2003/12/15 Diabetes and Alzheimer’s Disease: Are Brain Mitochondria a Link Between Both Pathologies? 1º Workshop de Bioquímica Clínica
(Porto, Portugal)
2003/12 Role of Insulin in Brain Mitochondria Status of Type 1 Diabetic Rats. Does Amyloid beta-Peptide Interferes with Mitochondrial Function? 16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine
2002/07/14 Bioenergética mitocondrial e o envelhecimento 16ª Reunião-Grupo de Estudos – Envelhecimento Cerebral e Demência
2001 Mitochondria: a target for beta-amyloid peptide XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica
(Coimbra, Portugal)
2000/07/02 Mitocôndria e o envelhecimento: efeito do peptídeo Abeta25-35 14ª Reunião - Grupo de Estudos: Envelhecimento Cerebral e Demência

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/05/23 - 2019/05/24 Symposium - Neurobiology of Aging; 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019 - 2019)
Simpósio
European Society for Clinical Investigation, Países Baixos
2019/04/08 - 2019/04/12 Advanced Course - Neurodegenerative Disorders PhD Programme in Experimental Biology and Biomedicine (2019 - 2019)
Outro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/02/25 - 2013/03/01 Advanced Course - Neurobiology and Disease Doctoral Programme in Health Sciences (2013 - 2013)
Outro (Coorganizador)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2012/12/10 - 2012/12/14 Advanced Course - Biology of Proteolysis in Pathology; PhD Programme in Experimental Biology and Biomedicine (2012 - 2012)
Outro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/05 - Atual Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2018 - Atual Journal of Alzheimer's Disease Reports IOS Press
2018 - Atual Diabetologia (1432-0428) Springer-Verlag
2018 - Atual Brain Behavior and Immunity (1090-2139) Elsevier
2018 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2018 - Atual Cellular and Molecular Life Sciences (1420-9071) Springer-Verlag
2018 - Atual EClinicalMedicine (2589-5370) Elsevier
2018 - Atual Nature Reviews Neurology (1759-4766) Springer Science and Business Media LLC
2018 - Atual Neurotherapeutics (1878-7479) Springer-Verlag
2017 - Atual Progress in Neurobiology (0301-0082) Elsevier
2017 - Atual Alzheimers Disease & Dementia (2578-6490) sPage.direcT
2017 - Atual American Journal of Alzheimer s Disease (1082-5207) SAGE Publications
2017 - Atual Molecular Biology Reports (1573-4978) Springer-Verlag
2016 - Atual Rejuvenation Research (1557-8577) Mary Ann Liebert
2016 - Atual Diabetes Obesity and Metabolism (1463-1326) Wiley (Blackwell Publishing)
2016 - Atual Nature Reviews Endocrinology (1759-5037) Springer Science and Business Media LLC
2016 - Atual The Lancet Diabetes & Endocrinology (2213-8587) Elsevier
2015 - Atual PeerJ (2167-8359) PeerJ
2015 - Atual BioMed Research International (2314-6141) Hindawi Limited
2015 - Atual Current Alzheimer Research (1567-2050) Bentham Science
2015 - Atual Journal of Clinical Investigation (1558-8238) American Society for Clinical Investigation
2015 - Atual Medicinal Research Reviews (1098-1128) Wiley (John Wiley & Sons)
2015 - Atual Neuropathology and Applied Neurobiology (1365-2990) Wiley (Blackwell Publishing)
2015 - Atual Expert Opinion on Drug Discovery (1746-045X) Informa UK (Taylor & Francis)
2015 - Atual Molecular Neurobiology (0893-7648) Springer-Verlag
2015 - Atual Trends in Neurosciences (0166-2236) Elsevier
2014 - Atual Therapeutic Advances in Chronic Disease (2040-6231) SAGE Publications
2014 - Atual Neuropharmacology (0028-3908) Elsevier
2014 - Atual Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2014 - Atual Trends in Biotechnology (0167-7799) Elsevier
2013 - Atual Expert Reviews in Molecular Medicine (1462-3994) Cambridge University Press
2012 - Atual Frontiers in Aging Neuroscience (1663-4365) Frontiers Media SA
2012 - Atual Diabetes
2012 - Atual Neurobiology of Disease (1095-953X) Elsevier
2012 - Atual Neurobiology of Disease (1095-953X) Elsevier
2012 - Atual Free Radical Biology and Medicine (0891-5849) Elsevier
2012 - Atual Neuroendocrinology (1423-0194) S. Karger AG
2012 - Atual Biochemical Pharmacology (0006-2952) Elsevier
2012 - Atual Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2010 - Atual Journal of Alzheimer s Disease (1875-8908) IOS Press
2010 - Atual Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2010 - Atual European Journal of Pharmacology (0014-2999) Elsevier
2009 - Atual Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2009 - Atual European Journal of Clinical Investigation (1365-2362) Wiley (Blackwell Publishing)
2009 - Atual Neurosciences (1658-3183) Neurosciences
2008 - Atual The FASEB Journal (1530-6860) Federation of American Society for Experimental Biology
2005 - Atual Experimental Neurology (1090-2430) Elsevier
2004 - Atual Expert Review of Neurotherapeutics (1744-8360) Informa UK (Taylor & Francis)
2013 - 2019 British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2016 - Atual Evaluator for European Science Foundation
Avaliador
European Science Foundation, França
2019/12 - 2020/12 Committee on Novo Nordisk Foundation Challenge Programme 2020 – Biomedicine and Health Sciences
Avaliador
Novo Nordisk Fonden, Dinamarca Novo Nordisk Fonden
2016 - 2020 Individual Fellowships | Marie Sklodowska-Curie Actions
Avaliador
Commission Européenne Représentation au Luxembourg, Luxemburgo Commission Européenne Représentation au Luxembourg
2017 - 2019 Evaluator of the Marie Sklodowska-Curie Individual Fellowships (Life Sciences Panel)
Avaliador
European Commission, Bélgica European Commission
2017 - 2019 Evaluator of applications - Alzheimer's Association Research Grant Program
Avaliador
Alzheimer's Association, Estados Unidos Alzheimer's Association
2018 - 2018 Evaluator of applications within the call “What causes Brain Disease?"
Avaliador
Lundbeckfonden, Dinamarca Lundbeckfonden
2016 - 2018 Evaluator of applications Agence nationale de la recherche, França Agence nationale de la recherche
2014 - 2015 Evaluator Post-Doctoral Fellowships (Experimental Biology and Biochemistry Panel)
Avaliador
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal), Portugal Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2012 - Atual Fundamentos de Fisiologia II Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/02 - Atual Fisiologia Humana Geral Mestrado Integrado em Medicina Dentária (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2011 - Atual Fundamentos de Fisiologia I Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Atual Fundamentos de Fisiologia II Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Atual Fundamentos de Fisiologia I Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006/02 - Atual Fisiologia II (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2005/12/01 - Atual Fisiologia I Mestrado Integrado em Medicina (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal

Membro de associação

Nome da associação Tipo de participação
2007 - Atual Portuguese Society of Diabetology Membro
2007 - Atual European Association for the Study of Diabetes Membro
2006 - Atual Portuguese Society for Neuroscience Membro

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2019/05/22 - 2019/05/24 Scientific committee - 53rd Annual Meeting of the European Society for Clinical Investigation (ESCI)
Membro
European Society for Clinical Investigation, Países Baixos
2018/07/13 - 2018/07/13 Scientific Committee - International Symposium; MitoPorto – Mitochondrial evolution, metabolism and disease
Outro
2013/05/30 - 2013/06/01 Organizing committee - XIII Reunião da Sociedade Portuguesa de Neurociências
Membro
Distinções

Prémio

2017 Orlando Leitão Prize
Sociedade Portuguesa de Neurologia, Portugal
2015 Mantero Belard Prize
Santa Casa da Misericórdia de Lisboa, Portugal
2014 2nd prize for research project
Sociedade Portuguesa de Diabetologia, Portugal
2013 Best Research Paper - Basic Science
Universidade de Coimbra - Faculdade de Medicina, Portugal
2010 ASN Neuro Poster Prize
American Society of Neurochemistry, Estados Unidos
2008 L'Oreal for Women in Science award
L’Oreal Portugal , Portugal

Comissão Nacional da UNESCO , Portugal

Fundação para a Ciência e a Tecnologia, Portugal
2003 Stimulus to Research Prize
Fundação Calouste Gulbenkian, Portugal
2003 Best Poster Prize
Physiological Society, Reino Unido

Título

2018 Member of the Dana Alliance for Brain Initiatives
Dana Foundation, Estados Unidos
2018 Member of European Science Foundation (ESF) College of Expert Reviewers
European Science Foundation, França